CN103405775A - Hollow gracilaria polysaccharide capsule and preparation method thereof - Google Patents
Hollow gracilaria polysaccharide capsule and preparation method thereof Download PDFInfo
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- CN103405775A CN103405775A CN2013103254537A CN201310325453A CN103405775A CN 103405775 A CN103405775 A CN 103405775A CN 2013103254537 A CN2013103254537 A CN 2013103254537A CN 201310325453 A CN201310325453 A CN 201310325453A CN 103405775 A CN103405775 A CN 103405775A
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Abstract
The invention provides a hollow gracilaria polysaccharide capsule and a preparation method thereof. The hollow gracilaria polysaccharide capsule is prepared from the following main raw materials: 100 g of gracilaria polysaccharide, 35-45 g of carrageen gum, 10-12 g of KCl, 50-80 g of glycerol, 38-42 g of amylum, 180-200 g of hydroxy propyl methyl cellulose and 450-1000 mL of anhydrous ethyl alcohol. The capsule has the benefits as follows: (1), the hollow gracilaria polysaccharide capsule has the advantages of a vegetal hollow capsule, does not use animal source materials, and is suitable for vegetarians and Islamic people; (2), according to the capsule and the method, the gracilaria polysaccharide is firstly used as a raw material, the preparation process is simple, and industrialization is easy to implement.
Description
(1) technical field
The present invention relates to a kind of Gracilaria gigas Harvey polysaccharides Capsules and preparation method thereof.
(2) background technology
At present, China's Capsules still be take the gelatin Capsules and is principal item, and the gelatin Capsules is to filling medicine, religion crowd, preservation conditions etc. have limitation, and people thirst for developing nontoxic, without the new material Capsules of custom restriction, plant hollow capsule arises at the historic moment.
The plant hollow capsule that the Sargassum polysaccharides of take is developed as flocculation agent becomes study hotspot in recent years, and sodium alginate, carrageenan etc. all is applied to the preparation of plant hollow capsule.Its preparation method such as patent " preparation method of a kind of vegetable polysaccharides Capsules feedstock composition and Capsules ", step is: this Capsules feedstock composition contains K-carrageenan 0.5-26 weight portion, cellulose derivative and/or resin 75-98 weight portion, alcohols 1-12 weight portion.Its preparation method is except alcohols, and other raw materials are placed in reaction vessel, adds water, adds alcohols in the above-mentioned raw materials course of dissolution, forms glue, forms Capsules through dipping in glue, oven dry, demoulding, cutting, fit.Patent " a kind of sodium alginate capsule and production technology thereof ", step is: taking percentage by weight is 7.0～11.0% sodium alginate, 1.0～4.0% locust bean gum, 2.0～5.0% CaCO
3, 2.0～5.0% NaHCO
3, 2.0～4.0% plasticizer, put into 75.0～80.0% distilled water and 2.0～5.0% Oleum Cocois mixed solution, through colloidal sol, be incubated, dip in gum forming, drying, pull out shell, after cutting, arrangement, packaging and other steps and get final product.
Rhodophyta Gigartinales Gracilaria tenuistipitata section Gracilaria plant Gracilaria tenuistipitata is the feature breed of the coastal algae culturing in Zhejiang Province, in Gracilaria tenuistipitata, contain a large amount of polysaccharose substances, be used to the production of agar in the past, and be flocculation agent and take Gracilaria gigas Harvey polysaccharides, the exploitation plant hollow capsule has no relevant report.
(3) summary of the invention
The object of the invention is to provide a kind of Gracilaria gigas Harvey polysaccharides Capsules and preparation method thereof.
The technical solution used in the present invention is:
A kind of Gracilaria gigas Harvey polysaccharides Capsules, mainly by the following raw material of proportioning, made:
Above-mentioned raw materials is the primary raw material for preparing Capsules, does not comprise the water that preparation process is used.
Described Gracilaria gigas Harvey polysaccharides is that Rhodophyta Gigartinales Gracilaria tenuistipitata section Gracilaria plant Gracilaria tenuistipitata is through extracting the polysaccharide material obtained, can be prepared by this area conventional method, for example, (Wang Tanghong is Zhang Guangying king's Flos Salicis Babylonicae eastwards with reference to the method for CN101475651A, or with reference to " research of Gracilaria gigas Harvey polysaccharides separation-extraction technology "; " light science and technology " 01 phase in 2012) method in.Preferably, described Gracilaria gigas Harvey polysaccharides molecular weight is 5000～10000.
The invention still further relates to the method for the described Gracilaria gigas Harvey polysaccharides Capsules of preparation, described method comprises:
(1) Gracilaria gigas Harvey polysaccharides of formula ratio is mixed with the solid-liquid ratio of 70～80 ℃ of distilled water by 1g: 18～20mL, constantly stir until form clear solution;
In above-mentioned clear solution, first add the carrageenan of formula ratio, stir until carrageenan dissolves, and then add KCl and the glycerol of formula ratio, in 75～85 ℃ of water-bath 30～40min, obtain glue;
(2) according to 1g: the solid-liquid ratio of 23～27mL, the starch of formula ratio is dissolved in to distilled water, obtain starch solution;
According to the solid-liquid ratio of 95g: 450～550mL, the hydroxypropyl emthylcellulose of formula ratio is dissolved in to the distilled water of 35～45 ℃, obtain Gonak;
Starch solution and Gonak are mixed, obtain mixed liquor, in mixed liquor, add the dehydrated alcohol (accounting for mixeding liquid volume 30～40%) of formula ratio, rear supersound process 20～30min stirs;
(3) by the mixed liquor after step (2) supersound process and step (1) gained glue in 50～60 ℃ of water-bath 40～50min, obtain the capsule material liquid;
(4) the capsule material liquid is made to Capsules according to a conventional method, obtain described Gracilaria gigas Harvey polysaccharides Capsules.
Preferably, in step (2), the ultrasonic power of supersound process is 200W, and frequency is 40HZ.
Beneficial effect of the present invention is mainly reflected in: (1) the present invention has possessed the advantage of plant hollow capsule: do not use the animal sources material, be applicable to vegetarian and Islam crowd edible; (2) to have adopted first Gracilaria gigas Harvey polysaccharides be raw material in the present invention, and preparation process is simple, is easy to industrialization.
(4) specific embodiment
The present invention is described further below in conjunction with specific embodiment, but protection scope of the present invention is not limited in this:
Embodiment 1: the preparation of Gracilaria gigas Harvey polysaccharides
Fresh Gracilaria tenuistipitata, through rinsing, is removed the dirt of surface attachment, is placed in 80 ℃ of baking ovens and dries, and is ground into powder, gets the 20kg powder and is placed in extraction pot, adds the 90% soak with ethanol backflow 2h degrease of 200L, filters; In filtering residue, add the 200L distilled water, extract 6h in 90 ℃ of water-baths, filter and collect filtrate, Gracilaria tenuistipitata residue adding distil water again, to 200L, extracts 6h in 90 ℃ of water-baths, filters and collects filtrate, discards residue, merging filtrate.The filtrate decompression distillation and concentration, to 100L, adds the ethanol of 250L95% to stir precipitation, filters and collects polysaccharide precipitation, reclaim ethanol, add the 80L distilled water and dissolve polysaccharide, add 20L Sevag reagent (chloroform: n-butyl alcohol=4:1, v/v), stir, remove lower floor's albumen and organic solvent layer.Gained polysaccharide liquid is concentrated into 50L and adds the ethanol of 3.5 times of volumes 95% to stir precipitation, filter collecting precipitation, successively with dehydrated alcohol, acetone, ether, chloroform washing, obtain the Gracilaria tenuistipitata crude polysaccharides, add the 200L distilled water, carry out ultrafiltration with the film that the interception molecular weight is 10K, filter liquor employing molecular cut off is that the ultrafilter membrane film of 5K carries out ultrafiltration, get the concentrated solution vacuum rotating concentrated, lyophilization, obtain the Gracilaria gigas Harvey polysaccharides that molecular weight is molecular weight between 5K-10K.
Embodiment 2:
1), will with 80 ℃ of distilled water of 18L, mix according to the Gracilaria gigas Harvey polysaccharides 1kg that embodiment 1 method makes, constantly stir until form clear solution;
In above-mentioned clear solution, first add the carrageenan of 350g, stir until carrageenan dissolves; And then add the KCl of 100g and the glycerol of 546g, in 75 ℃ of water-bath 30min, obtain glue;
2), according to 1:25(g:mL) solid-liquid ratio, 380g starch is dissolved in to the 9.5L distilled water, obtain starch solution;
According to 95:450(g:mL) solid-liquid ratio, 1.9kg hydroxypropyl shuttle methylcellulose is dissolved in to the distilled water of the 9L of 35 ℃, obtain hydroxypropyl shuttle methocel solution;
Starch solution and hydroxypropyl shuttle methocel solution are mixed, obtain mixed liquor; The dehydrated alcohol that adds 6L in mixed liquor, stir rear ultrasonic (200W power, 40HZ frequency) processes 30min;
3), by step 2) gains mix with the glue of step 1) gained, in 50 ℃ of water-bath 50min, obtain the capsule material liquid.
4), the capsule material liquid automatically dipping on the glue production line through dipping in gum forming, drying, pull out shell, after cutting, arrangement, packing, get final product to obtain the Gracilaria gigas Harvey polysaccharides Capsules.
Embodiment 3:
1), Gracilaria gigas Harvey polysaccharides 800g is mixed with 80 ℃ of distilled water of 16L, constantly stir until form clear solution;
In above-mentioned clear solution, first add the carrageenan of 360g, stir until carrageenan dissolves; And then add the KCl of 96g and the glycerol of 584g, in 85 ℃ of water-bath 40min, obtain glue;
2), according to 1:27(g:mL) solid-liquid ratio, the starch of 336g is dissolved in to the distilled water of 9L, obtain starch solution;
According to 95:550(g:mL) solid-liquid ratio, the hydroxypropyl shuttle methylcellulose of 1.6kg is dissolved in to 45 ℃ of distilled water of 9.2L, obtain hydroxypropyl shuttle methocel solution;
Starch solution and hydroxypropyl shuttle methocel solution are mixed, obtain mixed liquor; The dehydrated alcohol that adds 7.2L in mixed liquor, stir rear ultrasonic (frequency of 40HZ, the power of 200W) processes 30min;
3), by step 2) gains mix with the glue of step 1) gained, in 60 ℃ of water-bath 40min, obtain the capsule material liquid.
4), the capsule material liquid automatically dipping on the glue production line through dipping in gum forming, drying, pull out shell, after cutting, arrangement, packing, get final product to obtain the Gracilaria gigas Harvey polysaccharides Capsules.
Embodiment 4:
1), Gracilaria gigas Harvey polysaccharides 3kg is mixed with 75 ℃ of distilled water of 57L, constantly stir until form clear solution;
In above-mentioned clear solution, first add the carrageenan of 1.2kg, stir until carrageenan dissolves; And then add the KCl of 330g and the glycerol of 1.5kg, in 80 ℃ of water-bath 35min, obtain glue;
2), according to 1:23(g:mL) solid-liquid ratio, the starch of 1.2kg is dissolved in to the distilled water of 27.6L, obtain starch solution; According to 95:500(g:mL) solid-liquid ratio, the hydroxypropyl shuttle methylcellulose of 5.4kg is dissolved in to 40 ℃ of distilled water of 28.4L, obtain hydroxypropyl shuttle methocel solution;
Starch solution and hydroxypropyl shuttle methocel solution are mixed, obtain mixed liquor; The dehydrated alcohol that adds 19.6L in mixed liquor, stir rear ultrasonic (frequency of 40HZ, the power of 200W) processes 25min;
3), by step 2) gains mix with the glue of step 1) gained, in 55 ℃ of water-bath 45min, obtain the capsule material liquid.
4), the capsule material liquid automatically dipping on the glue production line through dipping in gum forming, drying, pull out shell, after cutting, arrangement, packing, get final product to obtain the Gracilaria gigas Harvey polysaccharides Capsules.
The Gracilaria gigas Harvey polysaccharides Capsules that above-described embodiment 2～embodiment 4 preparations are obtained detects according to the method for the medicinal hollow capsule of Chinese Pharmacopoeia 2010 editions, and result is as follows:
Finally, it is also to be noted that, what more than enumerate is only several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention, all should think protection scope of the present invention.
Claims (3)
1. Gracilaria gigas Harvey polysaccharides Capsules, mainly by the following raw material of proportioning, made:
2. Gracilaria gigas Harvey polysaccharides Capsules as claimed in claim 1, is characterized in that described Gracilaria gigas Harvey polysaccharides divides
The son amount is 5000～10000.
3. the method for preparing Gracilaria gigas Harvey polysaccharides Capsules as claimed in claim 1, described method comprises:
(1) Gracilaria gigas Harvey polysaccharides of formula ratio is mixed with the solid-liquid ratio of 70～80 ℃ of distilled water by 1g: 18～20mL, constantly stir until form clear solution;
In above-mentioned clear solution, first add the carrageenan of formula ratio, stir until carrageenan dissolves, and then add KCl and the glycerol of formula ratio, in 75～85 ℃ of water-bath 30～40min, obtain glue;
(2) according to 1g: the solid-liquid ratio of 23～27mL, the starch of formula ratio is dissolved in to distilled water, obtain starch solution;
According to the solid-liquid ratio of 95g: 450～550mL, the hydroxypropyl emthylcellulose of formula ratio is dissolved in to the distilled water of 35～45 ℃, obtain Gonak;
Starch solution and Gonak are mixed, obtain mixed liquor, in mixed liquor, add the dehydrated alcohol of formula ratio, rear supersound process 20～30min stirs;
(3) by the mixed liquor after step (2) supersound process and step (1) gained glue in 50～60 ℃ of water-bath 40～50min, obtain the capsule material liquid;
(4) the capsule material liquid is made to Capsules, obtain described Gracilaria gigas Harvey polysaccharides Capsules.
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| CN201310325453.7A CN103405775B (en) | 2013-07-30 | 2013-07-30 | A kind of hollow gracilaria polysaccharide capsule and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877586A (en) * | 2014-03-25 | 2014-06-25 | 暨南大学 | Medical hard capsule shell material with eucheuma gelatinae polysaccharide and preparation method thereof |
| CN112812379A (en) * | 2021-02-03 | 2021-05-18 | 华南理工大学 | Degradable film and preparation method thereof |
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| CN101069677A (en) * | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | Pullulan polysaccharide hollow hard capasule and its preparing method |
| CN102499910A (en) * | 2011-12-15 | 2012-06-20 | 山西吉呈生物技术有限公司 | Hard-shell capsule based on pullulan |
| CN102805871A (en) * | 2011-06-02 | 2012-12-05 | 石法堂 | Material of soybean polysaccharide hollow capsule and production method of capsule |
| CN102895215A (en) * | 2012-10-18 | 2013-01-30 | 广西南宁汇润生物科技有限公司 | Cellulose and red alga polysaccharide plant empty capsule and raw material composition and preparation method thereof |
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2013
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069677A (en) * | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | Pullulan polysaccharide hollow hard capasule and its preparing method |
| CN102805871A (en) * | 2011-06-02 | 2012-12-05 | 石法堂 | Material of soybean polysaccharide hollow capsule and production method of capsule |
| CN102499910A (en) * | 2011-12-15 | 2012-06-20 | 山西吉呈生物技术有限公司 | Hard-shell capsule based on pullulan |
| CN102895215A (en) * | 2012-10-18 | 2013-01-30 | 广西南宁汇润生物科技有限公司 | Cellulose and red alga polysaccharide plant empty capsule and raw material composition and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877586A (en) * | 2014-03-25 | 2014-06-25 | 暨南大学 | Medical hard capsule shell material with eucheuma gelatinae polysaccharide and preparation method thereof |
| CN103877586B (en) * | 2014-03-25 | 2016-06-29 | 暨南大学 | Medicinal hard capsule shell material containing eucheuma gelatinae polysaccharide and preparation method |
| CN112812379A (en) * | 2021-02-03 | 2021-05-18 | 华南理工大学 | Degradable film and preparation method thereof |
| CN112812379B (en) * | 2021-02-03 | 2022-01-04 | 华南理工大学 | Degradable film and preparation method thereof |
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| CN103405775B (en) | 2015-08-05 |
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