CN103405488A - Cataplasm used for treating skin scars, and preparation method thereof - Google Patents
Cataplasm used for treating skin scars, and preparation method thereof Download PDFInfo
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- CN103405488A CN103405488A CN2013103522032A CN201310352203A CN103405488A CN 103405488 A CN103405488 A CN 103405488A CN 2013103522032 A CN2013103522032 A CN 2013103522032A CN 201310352203 A CN201310352203 A CN 201310352203A CN 103405488 A CN103405488 A CN 103405488A
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Abstract
The invention relates to cataplasm used for treating skin scars, and a preparation method thereof. The cataplasm is composed of, by weight: 1-50 parts of sesame oil, 1-10 parts of cactus juice, 0.1-10 parts of carbomer, 0.05-5 parts of tartaric acid, 0.05-10 parts of polyvinyl alcohol, 0.05-10 parts of sodium carboxymethyl cellulose, 0.01-10 parts of disodium ethylenediamine tetraacetate, 0.5-10 parts of sodium polyacrylate, 0.1-10 parts of polyvinyl pyrrolidone, 5-50 parts of glycerin, 0.005-1 part of aluminum glycinate, 0.005-1 part of menthol, 0.05-5 parts of titanium dioxide, 0.1-5 parts of an emulsifier, 0.1-10 parts of beta-cyclodextrin, and 40-70 parts of water. With the cataplasm, defects of low fat-soluble content and low adhesion of traditional cataplasm are overcome, and scars can be treated by using a mixture of sesame oil and cactus juice through a transdermal administration approach.
Description
Technical field
The present invention relates to a kind of transdermal delivery system, concrete is a kind of skin scar cataplasma and preparation method thereof for the treatment of.
Background technology
Dispel one of the principle of scar of Oleum sesami is in Oleum sesami, to contain more vitamin E, can maintain the permeability of blood vessel, improves peripheral circulation, well safeguards epithelial tissue, promotes local blood circulation, repairs cicatrix skin.Simultaneously, the unsaturated fatty acid that Oleum sesami is contained, can participate in the metabolism of phospholipid, and cell membrane is synthetic, and skin is had to protection and anti-aging effect.And Oleum sesami is lubricated and not volatile, moistening effect is good, is beneficial to the regeneration of compromised skin and the invasion and attack of minimizing pathogenic bacteria.
The Radix et Caulis Opuntiae Dillenii juice is rich in the nutritional labelings such as cheese ammonia, trace element, vitamin, polysaccharide, plant collagen, can be skin nutrition is provided, and promotes skin metabolism, can strengthen wound healing, suppresses inflammation and the formation that prevents cicatrix.
Cataplasma can hydration skin, is aided with penetration enhancer, makes the transmission of active component percutaneous, is innovation and development to traditional external use plaster.
The technology for preparing cataplasma with beta-cyclodextrin inclusion compound volatile oil has had many pieces of bibliographical informations, but its oil content comprised is all lower.
Chinese invention patent (grant number CN1754532A) discloses a kind of catablasm base material and preparation method that contains emulsifying agent, it adopts emulsifying agent acrylate/C10-30 alkyl acrylate cross-linked copolymer as emulsifying agent, with catablasm base material prepared by such particular emulsifier, can comprise oil soluble active ingredients or oils active component; This kind method carrying drug ratio is low, and the cataplasma adhesion strength is low, and emulsifying agent is carbomer homologue, and drug release rate is excessively slow.
Summary of the invention
The object of the present invention is to provide a kind of skin scar cataplasma and preparation method thereof for the treatment of, it is low that it has overcome the fat-soluble content of traditional cataplasma, and the shortcoming that adhesion strength is poor has proposed with Oleum Sesami Radix et Caulis Opuntiae Dillenii juice mixture by transdermal administration approach treatment cicatrix.
For solving the problems of the technologies described above, the present invention is achieved in that
A kind of cataplasma for the treatment of skin scar, it is characterized in that: it according to the composition of parts by weight is, 1～50 part of Oleum sesami, 1～10 part of Radix et Caulis Opuntiae Dillenii juice, 0.1～10 part of carbomer, 0.05～5 part, tartaric acid, 0.05～10 part of polyvinyl alcohol, 0.05～10 part of sodium carboxymethyl cellulose, 0.01～10 part of disodiumedetate, 0.5～10 part of sodium polyacrylate, 0.1～10 part of polyvinylpyrrolidone, 5～50 parts of glycerol, 0.005～1 part of dihydroxyaluminum aminoacetate, 0.005～1 part of menthol, 0.05～5 part of titanium dioxide, 0.1～5 part of emulsifying agent, 0.1～10 part of beta-schardinger dextrin-, 40～70 parts, water.
The cataplasma of described treatment skin scar is characterized in that: described emulsifying agent is a kind of or mixture in tween 80 and Arlacel-80.
The cataplasma of described treatment skin scar is characterized in that: described Oleum sesami Radix et Caulis Opuntiae Dillenii juice mixture adds beta-cyclodextrin inclusion compound.
A kind of preparation method of cataplasma for the treatment of skin scar as above, it is characterized in that: concrete steps are, tartaric acid is soluble in water, adds carbomer to stir swelling, continues to add polyvinyl alcohol and the disodium ethylene diamine tetra-acetic acid solution mixed liquor I that stirs to obtain; By sodium polyacrylate, polyvinylpyrrolidone, sodium carboxymethyl cellulose, dihydroxyaluminum aminoacetate, titanium dioxide, be placed in 1/3rd glycerol, stirs evenly to obtain the glycerol phase; Beta-schardinger dextrin-is dissolved in boiling water, under water bath condition, adds Oleum sesami Radix et Caulis Opuntiae Dillenii juice mixture to carry out enclose, then add the emulsifying agent that is dissolved with menthol, stir, slowly add the glycerol phase in this enclose liquid, stir evenly to obtain the mixed liquor II; The mixed liquor II is slowly added in the mixed liquor I, supply glycerol, stir evenly and obtain mastic and adopt and to prolong the platen press coating, place crosslinked getting final product.
Main points of the present invention are its constituent and manufacture method.For the more product of liposoluble constituent, the composition of cataplasma and proportioning are that selectively a certain amount of liposoluble constituent of beta-schardinger dextrin-energy enclose, increase its dissolubility in water; Carbomer and polyvinylpyrrolidone, can make liposoluble constituent be dispersed in mastic; And by after the emulsifying of liposoluble constituent enclose, with the glycerol blend, add in mixed liquor I, liposoluble constituent is difficult for separating out from cataplasma mastic surface; Thereby the curative effect of cataplasma and the adhesion strength of mastic have been guaranteed.
The specific embodiment
The invention discloses a kind of cataplasma for the treatment of skin scar, it according to the composition of parts by weight is, 1～50 part of Oleum sesami, 1～10 part of Radix et Caulis Opuntiae Dillenii juice, 0.1～10 part of carbomer, 0.05～5 part, tartaric acid, 0.05～10 part of polyvinyl alcohol, 0.05～10 part of sodium carboxymethyl cellulose, 0.01～10 part of disodiumedetate, 0.5～10 part of sodium polyacrylate, 0.1～10 part of polyvinylpyrrolidone, 5～50 parts of glycerol, 0.005～1 part of dihydroxyaluminum aminoacetate, 0.005～1 part of menthol, 0.05～5 part of titanium dioxide, 0.1～5 part of emulsifying agent, 0.1～10 part of beta-schardinger dextrin-, 40～70 parts, water.
Described emulsifying agent is a kind of or mixture in tween 80 and Arlacel-80.
Described Oleum sesami Radix et Caulis Opuntiae Dillenii juice mixture adds beta-cyclodextrin inclusion compound.
Below by some embodiment, further introduce the present invention.
Embodiment 1
3g tartaric acid is dissolved in 350mL water, adds the 10g carbomer to stir swelling, continue to add 10g polyvinyl alcohol and the 1.5g disodium ethylene diamine tetra-acetic acid solution mixed liquor I that stirs to obtain; By the 70g sodium polyacrylate, the 5g polyvinylpyrrolidone, the 5g sodium carboxymethyl cellulose, the 1.5g dihydroxyaluminum aminoacetate, 5g titanium dioxide, be placed in 50g glycerol, stirs evenly to obtain the glycerol phase; The 15g beta-schardinger dextrin-is dissolved in 100mL boiling water, under water bath condition, add 50g Oleum sesami and 5g Radix et Caulis Opuntiae Dillenii juice mixture to carry out enclose, add again the 20g tween and the 3.5g span mixed liquor that are dissolved with the 1.5g menthol, stir, in this enclose liquid, slowly add the glycerol phase, stir evenly to obtain the mixed liquor II.The mixed liquor II is slowly added in the mixed liquor I, supplement 100g glycerol, stir evenly and obtain mastic and adopt and prolong the platen press coating, place crosslinked cataplasma.
Embodiment 2
5g tartaric acid is dissolved in 300mL water, adds the 10g carbomer to stir swelling, continue to add 10g polyvinyl alcohol and the 1.5g disodium ethylene diamine tetra-acetic acid solution mixed liquor I that stirs to obtain; By the 80g sodium polyacrylate, the 5g polyvinylpyrrolidone, the 5g sodium carboxymethyl cellulose, the 1.5g dihydroxyaluminum aminoacetate, 0.5g titanium dioxide, be placed in 40g glycerol, stirs evenly to obtain the glycerol phase; The 15g beta-schardinger dextrin-is dissolved in 150mL boiling water, under water bath condition, add 100g Oleum sesami and 5g Radix et Caulis Opuntiae Dillenii juice mixture to carry out enclose, then add 30g tween and the 5g span mixed liquor that is dissolved with the 1.5g menthol, stir, in this enclose liquid, slowly add the glycerol phase, stir evenly to obtain the mixed liquor II.The mixed liquor II is slowly added in the mixed liquor I, supplement 100g glycerol, stir evenly and obtain mastic and adopt and prolong the platen press coating, place crosslinked cataplasma.
Embodiment 3
7g tartaric acid is dissolved in 350mL water, adds the 10g carbomer to stir swelling, continue to add 5g polyvinyl alcohol and the 1.5g disodium ethylene diamine tetra-acetic acid solution mixed liquor I that stirs to obtain; By the 30g sodium polyacrylate, the 5g polyvinylpyrrolidone, the 5g sodium carboxymethyl cellulose, the 2.5g dihydroxyaluminum aminoacetate, 0.5g titanium dioxide, be placed in 50g glycerol, stirs evenly to obtain the glycerol phase; The 10g beta-schardinger dextrin-is dissolved in 100mL boiling water, under 50 ℃ of water bath condition, dropping 200g Oleum sesami and 10g Radix et Caulis Opuntiae Dillenii juice mixture carry out enclose, add again the 30g tween and the 5g span mixed liquor that are dissolved with the 1.5g menthol, stir, in this enclose liquid, slowly add the glycerol phase, stir evenly to obtain the mixed liquor II.The mixed liquor II is slowly added in the mixed liquor I, supplement 100g glycerol, stir evenly and obtain mastic and adopt and prolong the platen press coating, place crosslinked cataplasma.
Be only preferred embodiment of the present invention in sum, not be used for limiting practical range of the present invention.Be that all equivalences of doing according to the content of the present patent application the scope of the claims change and modify, all should be technology category of the present invention.
Claims (4)
1. cataplasma for the treatment of skin scar, it is characterized in that: it according to the composition of parts by weight is, 1～50 part of Oleum sesami, 1～10 part of Radix et Caulis Opuntiae Dillenii juice, 0.1～10 part of carbomer, 0.05～5 part, tartaric acid, 0.05～10 part of polyvinyl alcohol, 0.05～10 part of sodium carboxymethyl cellulose, 0.01～10 part of disodiumedetate, 0.5～10 part of sodium polyacrylate, 0.1～10 part of polyvinylpyrrolidone, 5～50 parts of glycerol, 0.005～1 part of dihydroxyaluminum aminoacetate, 0.005～1 part of menthol, 0.05～5 part of titanium dioxide, 0.1～5 part of emulsifying agent, 0.1～10 part of beta-schardinger dextrin-, 40～70 parts, water.
2. the cataplasma for the treatment of skin scar according to claim 1, it is characterized in that: described emulsifying agent is a kind of or mixture in tween 80 and Arlacel-80.
3. the cataplasma for the treatment of skin scar according to claim 1, it is characterized in that: described Oleum sesami Radix et Caulis Opuntiae Dillenii juice mixture adds beta-cyclodextrin inclusion compound.
4. preparation method as the cataplasma of claim 1 or 2 or 3 described treatment skin scars, it is characterized in that: concrete steps are, tartaric acid is soluble in water, adds carbomer to stir swelling, continues to add polyvinyl alcohol and the disodium ethylene diamine tetra-acetic acid solution mixed liquor I that stirs to obtain; By sodium polyacrylate, polyvinylpyrrolidone, sodium carboxymethyl cellulose, dihydroxyaluminum aminoacetate, titanium dioxide, be placed in 1/3rd glycerol, stirs evenly to obtain the glycerol phase; Beta-schardinger dextrin-is dissolved in boiling water, under water bath condition, adds Oleum sesami Radix et Caulis Opuntiae Dillenii juice mixture to carry out enclose, then add the emulsifying agent that is dissolved with menthol, stir, slowly add the glycerol phase in this enclose liquid, stir evenly to obtain the mixed liquor II; The mixed liquor II is slowly added in the mixed liquor I, supply glycerol, stir evenly and obtain mastic and adopt and to prolong the platen press coating, place crosslinked getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310352203.2A CN103405488B (en) | 2013-08-13 | 2013-08-13 | One treats skin scar cataplasma and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310352203.2A CN103405488B (en) | 2013-08-13 | 2013-08-13 | One treats skin scar cataplasma and preparation method thereof |
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| CN103405488A true CN103405488A (en) | 2013-11-27 |
| CN103405488B CN103405488B (en) | 2015-12-09 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806823A (en) * | 2005-01-21 | 2006-07-26 | 北京东方凯恩医药科技有限公司 | Externally applied wind-expelling Chinese medicinal composition plaster |
| CN101524328A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Gel ointment for treating burn and scald |
| CN102266373A (en) * | 2011-08-04 | 2011-12-07 | 上海美宝生命科技有限公司 | Skin externally-used matrix for treating scar and preparation method thereof |
| KR20130028192A (en) * | 2011-09-09 | 2013-03-19 | 주식회사 금황제지 | Yellow soil, mineral compound mixed korean paper loess therapy massage face mask sheet pack |
| CN103083282A (en) * | 2011-11-03 | 2013-05-08 | 杭州炬九生物科技有限公司 | Novel hydrogel scar patch and its preparation process |
-
2013
- 2013-08-13 CN CN201310352203.2A patent/CN103405488B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806823A (en) * | 2005-01-21 | 2006-07-26 | 北京东方凯恩医药科技有限公司 | Externally applied wind-expelling Chinese medicinal composition plaster |
| CN101524328A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Gel ointment for treating burn and scald |
| CN102266373A (en) * | 2011-08-04 | 2011-12-07 | 上海美宝生命科技有限公司 | Skin externally-used matrix for treating scar and preparation method thereof |
| KR20130028192A (en) * | 2011-09-09 | 2013-03-19 | 주식회사 금황제지 | Yellow soil, mineral compound mixed korean paper loess therapy massage face mask sheet pack |
| CN103083282A (en) * | 2011-11-03 | 2013-05-08 | 杭州炬九生物科技有限公司 | Novel hydrogel scar patch and its preparation process |
Non-Patent Citations (1)
| Title |
|---|
| 杨华生等: "药用辅料在中药经皮给药制剂中的应用", 《中医外治杂志》 * |
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| CN103405488B (en) | 2015-12-09 |
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