CN103393731B - One drives mercurial - Google Patents
One drives mercurial Download PDFInfo
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- CN103393731B CN103393731B CN201310313445.0A CN201310313445A CN103393731B CN 103393731 B CN103393731 B CN 103393731B CN 201310313445 A CN201310313445 A CN 201310313445A CN 103393731 B CN103393731 B CN 103393731B
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- mercurial
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- margarita powder
- powder
- carotene
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Abstract
The invention discloses one and drive mercurial, comprise the Margarita powder as effective ingredient and juice of Fructus Hippophae, described Margarita powder adopts the physical method such as ball milling or comminution by gas stream to obtain, described in drive mercurial and also comprise pectin, carotene, reduced glutathion and glucosan.The described component of driving mercurial and comprising following percentage by weight: the Margarita powder of 20%-40%, the juice of Fructus Hippophae of 1%-5%, the milk powder of 2%-7%, the pectin of 1%-2%, 3%-7% reduced glutathion, the carotene of 0.1%-1%, the glucosan of 0.2%-0.8%, surplus is brown sugar.Take this and drive mercurial, mercurialism is had to the effect alleviated toxicity and even detoxify.
Description
Technical field
The present invention relates to one and drive mercurial.
Background technology
Hydrargyrum is argenteous liquid metal, namely has evaporation in room temperature.Mercury vapour is easier in the cell membrane of alveolar wall containing lipid, with the lipid binding in blood, is distributed to whole body very soon and respectively organizes.Hydrargyrum is oxidized to Hg2+ in erythrocyte and other tissue, and with protein bound and accumulating, to be very difficultly released again.Along with the deterioration of industrial expansion and environment, in productive life, hydrargyrum is easy to gather in vivo, and research shows that hydrargyrum can cause lipid peroxidation, makes concentration of oxygen free radicals increase, finally make the scavenging action of body to free radical weaken, significant damage is caused to the health of people.
Main in Margarita powder have resisting fatigue, looks improving and the skin nourishing, Improving memory power containing Multiple components such as several amino acids, trace element and biological calciums, improves immunity and have therapeutic effect to various diseases.Modern pharmacological research and clinical observation show; Margarita powder has the effect such as obvious CNS inhibition, dredging microcirculation, immunological enhancement, neuroprotective archeocyte, slow down aging, antiinflammatory, obtains good prevention effect in nutrition and health care and wound etc.
Containing multivitamin, fatty acid, trace element, sub-oil element, Fructus Hippophae flavone, superoxides isoreactivity material in juice of Fructus Hippophae, the absorption of biological calcium can be promoted, significantly improve body immunity.
Other vegetable polysaccharides and polypeptide etc. are to removing people interior free yl, and alleviating mercurialism has certain effect.
Current acute mercurialism generally still adopts a large amount of protein of picked-up to protect the method for gastric mucosa; then two coloured glaze base propanol sodium sulfonate intramuscular injection are adopted; but easily there is acute renal failure, not yet have the suitable mercurial that drives effectively alleviate and remove mercurialism, especially chronic mercury poisoning.
Summary of the invention
The object of this invention is to provide and drive mercurial and effectively alleviate and even remove mercurialism.For achieving the above object, the present invention takes following technical proposals to realize:
The invention provides one and drive mercurial, comprise the Margarita powder as effective ingredient and juice of Fructus Hippophae.
Further, drive mercurial described in and also comprise pectin, carotene, reduced glutathion and glucosan.
Further, the component that mercurial comprises following percentage by weight is driven described in: the Margarita powder of 20%-40%, the juice of Fructus Hippophae of 1%-5%, the milk powder of 2%-7%, the pectin of 1%-2%, 3%-7% reduced glutathion, the carotene of 0.1%-1%, the glucosan of 0.2%-0.8%, surplus is brown sugar.
Preferably, described in drive the component that mercurial comprises following percentage by weight: the Margarita powder of 25%-35%, the juice of Fructus Hippophae of 2%-4%, the milk powder of 3%-6%, the pectin of 1.2%-1.6%, 4%-6% reduced glutathion, the carotene of 0.5%-0.8%,
The glucosan of 0.5%-0.8%, surplus is brown sugar.
Preferred, described in drive the component that mercurial comprises following percentage by weight: the Margarita powder of 32.1%, the juice of Fructus Hippophae of 3%, the milk powder of 5%, the pectin of 1.4%, 5% reduced glutathion, the carotene of 0.7%, the glucosan of 0.7%, the brown sugar of 52.1%.
In the present invention, described Margarita powder adopts the physical method such as ball milling or comminution by gas stream to obtain.
Further, the granularity of described Margarita powder is below 100 orders.
Preferably, the granularity of described Margarita powder is below 1000 orders.
Provided by the inventionly drive Margarita powder in mercurial and have and strengthen the activity of superoxide dismutase, suppress, the effect of scavenging free radicals, with juice of Fructus Hippophae with the use of, body can be impelled better to absorb Margarita powder.Zoopery shows, of the present inventionly drive the activity that mercurial obviously can promote superoxide dismutase in mercurialism Mice Body, reduce the content of malonaldehyde simultaneously, namely drive mercurial and there is certain antioxidation, simultaneously can scavenging free radicals, reduce the peroxide malonaldehyde to the toxic effect of body, thus can conclude that the mercurial that drives of the present invention has the effect of driving away hydrargyrum in body, can alleviate and even remove mercurialism.
The mercurial that drives provided by the invention can be used as feed additive, alleviates and even removes chronic animals mercurialism.Also can be passed through retrofit, drive mercurial medicine as one and take, alleviate and even remove human body mercurialism.Of the present inventionly drive mercurial safety, have no side effect, be suitable for human body and animal uses.
Drive in the present invention in mercurial and also added pectin and glucosan two kinds of polysaccharide, can be combined with hydrargyrum, reduce the concentration of mercury ion in blood, accelerate the eliminating of mercury ion, reduce blood mercury content, and drive other components matching in mercurial and use, effectively can alleviate mercurialism.
Reduced glutathion is also added in the present invention, it is by the combined with radical in sulfydryl and body, changes into the acid of easy metabolism thus accelerates the excretion of free radical, same with drive other components matching in mercurial, effective alleviation mercurialism, reduces the infringement to body.
With the addition of carotene in the present invention, carotene can safeguard that cytomicrosome film is complete, stops the generation of oxygen-derived free radicals, the carotene of optimal dose with drive other components matching in mercurial, effectively alleviate mercurialism.
Further, in the present invention, Margarita powder adopts physical method to obtain, and does not add any other material, does not also destroy any material, maintain the integrity of the nutritional labeling of Margarita powder.
Further, in the present invention, the granularity of Margarita powder is thinner, and assimilation effect is better, and the effect of driving away hydrargyrum is also better, and integrated cost and effect are considered, selects the granularity of Margarita powder below 100 orders.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Drive Margarita powder used in mercurial in the present invention and can select mussel pearl or sea water pearls, owing to having certain impurity in the kernel of sea water pearls, therefore preferred mussel pearl.
Margarita powder used better drives hydrargyrum effect to ensure, Margarita powder prepared by preferred physical method, as traditional mechanical crushing method and ball mill pulverizing method; More fine-grained comminution by gas stream and vibrations can be prepared to mix comminuting method; And the High Temperature High Pressure decrepitation method and full low-temperature nano polishing etc. of nanometer pearl powder can be prepared.
Drive hydrargyrum effect in order to what reached in the present invention, need Margarita powder to be convenient to body and absorb, therefore preferred size is below 100 orders.
In addition in the present invention, the interpolation of milk powder, mainly in order to add protein, can select other protein sources to substitute.
Brown sugar in the present invention is mainly in order to provide energy source, other saccharides can be selected, preferred brown sugar is because brown sugar is the Caulis Sacchari sinensis commerieal sugar after simply and easy treat, except possessing the function of sugar, also containing multivitamin and trace element, drive other components matching in mercurial with the present invention to use, drive hydrargyrum better effects if.
Embodiment 1
Ball-milling method prepares Margarita powder
Get a certain amount of mussel pearl (being purchased from jewelry city, Zhuji City East China), after Margarita is crushed to granule, puts in aqueous alkali and soak, wash away greasy dirt and attachment, then use clear water rinsing to neutral, drain.Then be placed in ball milling cylinder, add appropriate distilled water, ball milling.Ball milling terminates rear taking-up and is placed in square plate evenly laying, and in electrothermostat, 140-160 DEG C is dried to drying.Margarita powder good for ball milling is taken out and lets cool, sieve in closed vibrosieve, obtain the Margarita powder of granularity between 100 order-200 orders.
Embodiment 2
Mercurial is driven in preparation
The Margarita powder 32.1g prepared in Example 1, adds 52.1g brown sugar, 5g milk powder, 5g reduced glutathion, 0.7g carotene mix homogeneously, then adds 3g juice of Fructus Hippophae in the pressed powder of mixing, 1.4g pectin, 0.7g glucosan stirs, and obtains and drives mercurial 100g.
Embodiment 3
Drive the alleviation mercurialism experimentation of mercurial
Experimentation of the present invention mainly comprises the mouse feeding after contaminating 24 hours to mercury oxide containing the food one week driving mercurial, and superoxide dismutase (SOD) vigor in its blood plasma and malonaldehyde (MDA) content are surveyed in the blood examination of getting mice.
Wherein total number born (T-SOD) measures meaning and principle:
The oxidative and anti-oxidative balance of superoxide dismutase (T-SOD) to body plays vital effect, and this enzyme can remove ultra-oxygen anion free radical (O
2 -.) Cell protection is from damage.
Ultra-oxygen anion free radical (O is produced by xanthine and xanthine oxidase response system
2 -.), the latter is oxidized azanol and forms nitrite, presents purple, survey its absorbance with visible spectrophotometer under the effect of developer.When containing SOD in sample, then there is narrow spectrum inhibitory action to ultra-oxygen anion free radical, the nitrite of formation is reduced, and the absorbance measuring pipe during colorimetric, lower than the absorbance of control tube, can obtain the SOD vigor in sample by formulae discovery.
Malonaldehyde (MDA) measures meaning and principle
Body produces oxygen-derived free radicals by enzyme system and non-enzyme system, and the latter can attack the polyunsaturated fatty acid (PUFA) in biomembrane, causes lipid peroxidation, and therefore forms lipid peroxide.The amount of thus testing MDA can reflect the snperoxiaized degree of body inner lipid, indirectly reflects the degree of cell injury.
Malonaldehyde (MDA) in lipid peroxide catabolite can with thiobarbituricacidα-(TBA) * condensation, formed red product, have maximum absorption band at 532nm place, because of substrate for thiobarbituricacidα-(TBA) claims TBA method in this way.
The mensuration of MDA usually cooperatively interacts with the mensuration of SOD, the height indirect reaction of the SOD vigor ability of body scavenging activated oxygen, and the order of severity that the height indirect reaction of MDA body cell is attacked by free radical, contribute to analyzing by the interpretation of result of SOD and MDA and drive the mitigation of mercurial to mercurialism.
laboratory animal and equipment
Material: experiment mice 20 ± 2g/ is (Shaoxing University Sheng Ke institute animal-free medium ground) only
Feedstuff (Shaoxing University Sheng Ke institute animal-free medium ground)
Drive mercurial (obtained in embodiment 2)
Reagent: distilled water (laboratory self-control)
Distilled water (laboratory self-control)
Superoxide dismutase SOD test kit (Nanjing is built up)
Malonaldehyde MDA test kit (Nanjing is built up)
Glacial acetic acid (analytical pure, acetic acid concentration >=99.5%)
UV-2102PCS ultraviolet-uisible spectrophotometer (You Ni can Instrument Ltd.)
DGG-9070B electric heating constant-temperature blowing drying box (Shanghai gloomy reliable test Instrument Ltd.)
AR2130 electronic balance (prunus mume (sieb.) sieb.et zucc. Teller-Tuo benefit instrument Shanghai company limited)
37 DEG C of thermostatical water baths
Desk centrifuge
Micropipettor
Ice machine
Electric furnace (CRLB-1500S, Zhaoqing gold ceremonial music Electrical Appliances Co., Ltd).
experimental procedure
(1) feedstuff preparation
Experimental group 1(drives mercurial low dose group): take 83mg and drive mercurial and to be mixed in 100g normal diet powder fully mixing and to add little water and stir and make little finger of toe size particles and be finally put in electric heating constant-temperature blowing drying box and dry at 65 DEG C of temperature.
Experimental group 2(drives dosage group in mercurial): take 208mg and drive mercurial and to be mixed in 100g normal diet powder fully mixing and to add little water and stir and make little finger of toe size particles and be finally put in electric heating constant-temperature blowing drying box and dry at 65 DEG C of temperature.
Experimental group 3(drives mercurial high dose group): take 332mg and drive mercurial and to be mixed in 100g normal diet powder fully mixing and to add little water and stir and make little finger of toe size particles and be finally put in electric heating constant-temperature blowing drying box and dry at 65 DEG C of temperature.
(2) prepared by agent of contaminating
Prepared by mercuric chloride solution: take 1g mercuric chloride powder dissolution in 1L distilled water with electronic balance, be stirred to and dissolve standardize solution completely.Measure 1ml mercuric chloride solution in this solution and dilute 10 times to 10ml, then get the 6ml(0.6mg mercuric chloride in diluent) be then the poisoning dosage of one group of (3) mice, four parts need be prepared altogether.
(3) mice contamination medicine feed experiment
1, at random experiment mice (body weight is even) is divided into 5 groups and often organizes 3, be respectively complete blank group, matched group, experimental group 1, experimental group 2, experimental group 3.
2, the mice of matched group and 3 groups of experimental grouies is carried out disposable contamination: mice is contaminated by 10mg/kg body weight oral administration mercuric chloride solution.
3, be fed with the feedstuff driving mercurial to mice after contaminating 24 hours, feed experimental group 1 every day 15g experimental group 1 containing driving mercurial feedstuff, namely the Margarita powder concentration of the feeding of every day is 200mg/kg, feed experimental group 2 every day 15g experimental group 2 containing driving mercurial feedstuff, namely the Margarita powder concentration of the feeding of every day is 500mg/kg, feed experimental group 3 every day 15g experimental group 3 containing driving mercurial feedstuff, namely the Margarita powder concentration of the feeding of every day is 800mg/kg, and completely blank group and matched group are normal diet.
the mensuration of experimental result and analysis
(1) SOD activity and MDA assay result
Feeding drove mercurial after seven days, got the serum of each group of mice respectively, measured SOD activity and MDA content.Wherein SOD determination of activity result is as shown in table 1.
Total SOD is active for table 1
As can be seen from Table 1, superoxide dismutase (SOD) activity after contamination in mice serum obviously reduces, taking the feedstuff after a week driving mercurial containing the present invention, superoxide dismutase (SOD) activity in mice serum has clear improvement, wherein experimental group 2, namely take middle dosage and drive the improvement effect of mercurial the most obviously, can find out that the concentration of Margarita powder is optimum concentration in the concentration of 500mg/kg.
In mice serum, MDA concentration is as shown in table 2.
MDA concentration in table 2 mice serum
As can be seen from Table 2, malonaldehyde (MDA) content after contamination in mice serum obviously raises, take malonaldehyde (MDA) content driven in feedstuff one week rear mice serum of mercurial containing the present invention obviously to reduce, wherein experimental group 2 and experimental group 3 effectiveness comparison good, can find out that the concentration of Margarita powder is optimum concentration in the concentration of 500mg/kg and 800mg/kg.
In sum, verify whether the mercurial that drives provided by the invention has to mice mercurialism the effect alleviating toxicity or even removing toxic substances by the scheme of drug treatment after first contaminating to mice, experimental result shows, the activity of the superoxide dismutase SOD after contamination in mice serum obviously declines, and malonaldehyde MDA content significantly increases, take containing the mercurial that drives of the present invention after one week, the activity of exposed Mice serum superoxide dismutases SOD has obvious rising, the content of malonaldehyde MDA is then remarkable minimizing, the driving mercurial the activation recovering of exposed Mice SOD in serum even can be made to close to the SOD activity level in normal non-exposed Mice body of suitable concn, MDA content also drops to close to the MDA content in normal non-exposed Mice body.As can be seen here, take of the present invention drive mercurial after, exposed Mice is played and alleviates toxicity and even remove the effect of toxicity, thus prove that originally driving mercurial has the effect that mercurialism is even removed in alleviation.
Although the present invention with preferred embodiment openly as above; but it is not for limiting the present invention; any those skilled in the art without departing from the spirit and scope of the present invention; the Method and Technology content of above-mentioned announcement can be utilized to make possible variation and amendment to technical solution of the present invention; therefore; every content not departing from technical solution of the present invention; the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all belong to the protection domain of technical solution of the present invention.
Claims (6)
1. drive a mercurial, it is characterized in that, comprise the Margarita powder as effective ingredient and juice of Fructus Hippophae, described in drive mercurial and also comprise pectin, carotene, reduced glutathion and glucosan, described in drive the component that mercurial comprises following percentage by weight:
The Margarita powder of 20%-40%,
The juice of Fructus Hippophae of 1%-5%,
The milk powder of 2%-7%,
The pectin of 1%-2%,
3%-7% reduced glutathion,
The carotene of 0.1%-1%,
The glucosan of 0.2%-0.8%,
Surplus is brown sugar.
2. according to claim 1ly drive mercurial, it is characterized in that, described in drive the component that mercurial comprises following percentage by weight:
The Margarita powder of 25%-35%,
The juice of Fructus Hippophae of 2%-4%,
The milk powder of 3%-6%,
The pectin of 1.2%-1.6%,
4%-6% reduced glutathion,
The carotene of 0.5%-0.8%,
The glucosan of 0.5%-0.8%,
Surplus is brown sugar.
3. according to claim 2ly drive mercurial, it is characterized in that, described in drive the component that mercurial comprises following percentage by weight:
The Margarita powder of 32.1%,
The juice of Fructus Hippophae of 3%,
The milk powder of 5%,
The pectin of 1.4%,
5% reduced glutathion,
The carotene of 0.7%,
The glucosan of 0.7%,
The brown sugar of 52.1%.
4. according to claim 1-3 any one, drive mercurial, it is characterized in that, described Margarita powder adopts ball milling or comminution by gas stream physical method to obtain.
5. according to claim 4ly drive mercurial, it is characterized in that, the granularity of described Margarita powder is below 100 orders.
6. according to claim 5ly drive mercurial, it is characterized in that, the granularity of described Margarita powder is below 1000 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310313445.0A CN103393731B (en) | 2013-07-24 | 2013-07-24 | One drives mercurial |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310313445.0A CN103393731B (en) | 2013-07-24 | 2013-07-24 | One drives mercurial |
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| Publication Number | Publication Date |
|---|---|
| CN103393731A CN103393731A (en) | 2013-11-20 |
| CN103393731B true CN103393731B (en) | 2016-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310313445.0A Expired - Fee Related CN103393731B (en) | 2013-07-24 | 2013-07-24 | One drives mercurial |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1271580A (en) * | 2000-04-20 | 2000-11-01 | 中国科学院地理研究所 | Medicine for treating and preventing saturnism and its preparing process |
| CN1739391A (en) * | 2005-09-27 | 2006-03-01 | 卢存国 | Lead-dispelling health food |
-
2013
- 2013-07-24 CN CN201310313445.0A patent/CN103393731B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1271580A (en) * | 2000-04-20 | 2000-11-01 | 中国科学院地理研究所 | Medicine for treating and preventing saturnism and its preparing process |
| CN1739391A (en) * | 2005-09-27 | 2006-03-01 | 卢存国 | Lead-dispelling health food |
Non-Patent Citations (3)
| Title |
|---|
| "BSO、GSH、VC 和DMPS 对汞肾毒性影响的实验研究";徐兆发等;《卫生研究》;20050930;第34卷(第5期);533-536 * |
| "驱汞食谱";无;《江苏氯碱》;20091231(第6期);38 * |
| "高原圣果牌清妍胶囊抗氧化作用的动物实验研究";张红梅等;《国际沙棘研究与开发》;20050131;第3卷(第1期);5-7 * |
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| Publication number | Publication date |
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| CN103393731A (en) | 2013-11-20 |
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