CN103341081A - Traditional Chinese medicine composition for treating hypertension and proteinuria - Google Patents
Traditional Chinese medicine composition for treating hypertension and proteinuria Download PDFInfo
- Publication number
- CN103341081A CN103341081A CN2013102875111A CN201310287511A CN103341081A CN 103341081 A CN103341081 A CN 103341081A CN 2013102875111 A CN2013102875111 A CN 2013102875111A CN 201310287511 A CN201310287511 A CN 201310287511A CN 103341081 A CN103341081 A CN 103341081A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- rhizoma
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition for treating hypertension and proteinuria. The composition comprises the following raw materials in parts by weight: 2-4 parts of raw Astragalus membranaceus, 2-4 parts of raw seed and 2-4 parts of corn stigma, 3-5 parts of Rhizoma Dioscoreae Nipponicae, 1-3 parts of solomon's seal, 1-2 parts of Ligusticum wallichii, 1-2 parts of pulp of dogwood fruit, 1-2 parts of fructus rosae laevigatae and 0.3-1 part of roasted leech. The composition provided by the invention has the advantages that the formula of the traditional Chinese medicine composition meets the principle of traditional Chinese medicine 'assistant and guide', has the functions of remarkably tonifying spleen and kidney and resolving dampness and dispelling wind, and can tonify spleen and kidney functions, so that refined nutritious substances are fixedly taken, and dampness and stasis are eliminated. The composition is used on the basis of reducing pressure by Western medicines, proteinuria can be controlled, and the kidney function is protected and pain of patients is alleviated. The number of the traditional Chinese medicines is fewer, and the composition is lower in cost, convenient to use and worthy of widely popularizing.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, is a kind of hypertension and albuminuretic Chinese medicine composition for the treatment of.
Background technology
Hypertension is modal chronic disease, and China now trouble number reaches 200,000,000.Studies show that the hypertension initial stage, the renal artery spasm namely took place, blood flow is reduced.After after a while, engender the kidney vascular lesion, producing light to moderate is the renal arteriolosclerosis of main performance with the renal ischaemia, occurs the renal tubules of slowly development and the infringement of glomerule function then, renal failure finally occurs.Nearly 20 years antihypertensive therapy, significantly reduced the generation of cardiovascular and cerebrovascular vessel events, but the renal damage that hypertension causes enters the patient of chronic renal failure then day by day to be increased, and in 10 years, the end stagerenaldisease sickness rate of the U.S. is with about speed increment of annual 9% in the past.The new patient of end stagerenaldisease who causes because of hypertension accounts for 28%.The patient who carries out renal transplantation because of hypertensive nephrosclerosis accounts for 25% of whole renal transplant recipients.China in 1999 dialysis is transplanted the registration report and is pointed out that in the chronic renal failure dialysis patient protopathy, hypertensive nephropathy has risen to the 3rd, and in the old people, then is in position first of the chronic renal insufficiency pathogenic factor.The hypertensive renal patient has expended a large amount of medical resources, has brought heavy spirit and financial burden for family and society.
Summary of the invention
The objective of the invention is at deficiency of the prior art, a kind of hypertension and albuminuretic Chinese medicine composition for the treatment of is provided.
Second purpose of the present invention is that a kind of application for the treatment of hypertension and albuminuretic Chinese medicine composition is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of hypertension and albuminuretic Chinese medicine composition for the treatment of, made by following bulk drugs: Radix Astragali, give birth to Semen Coicis, each 2-4 part of Stigma Maydis, Rhizoma Dioscoreae Nipponicae 3-5 part, Rhizoma Polygonati 1-3 part, Rhizoma Chuanxiong, Fructus Corni, each 1-2 part of Fructus Rosae Laevigatae, process Hirudo 0.3-1 part.
Preferably, made by following bulk drugs: Radix Astragali, give birth to Semen Coicis, each 2.5-3.5 part of Stigma Maydis, Rhizoma Dioscoreae Nipponicae 3.5-4.5 part, Rhizoma Polygonati 1.5-2.5 part, Rhizoma Chuanxiong, Fructus Corni, each 1-1.5 part of Fructus Rosae Laevigatae, process Hirudo 0.3-0.8 part.
Preferably, made by following bulk drugs: Radix Astragali, give birth to Semen Coicis, each 3 parts of Stigma Maydis, 4 parts of Rhizoma Dioscoreae Nipponicae, 2 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1 part of Fructus Rosae Laevigatae, process 0.3 part of Hirudo.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: the application of described Chinese medicine composition in preparation treatment hypertension and albuminuretic medicine.
The invention has the advantages that:
The full side's compatibility of Chinese medicine composition of the present invention meets Chinese medicine " monarch " principle; has significant strengthening spleen, tonifying kidney; removing dampness blood stasis dispelling effect; can strong spleen renal function; make precise and tiny astringency inducing, the humidifying stagnation resolvation, use can be controlled albuminuria on Western medicine blood pressure lowering basis; the protection renal function alleviates the patient suffering.The flavour of a drug number is less, and cost is lower, and medication is convenient, should be widely promoted.
The specific embodiment
Below in conjunction with embodiment the specific embodiment provided by the invention is elaborated.
A kind of hypertension and albuminuretic Chinese medicine composition for the treatment of made by following bulk drugs: Radix Astragali, give birth to Semen Coicis, each 2-4 part of Stigma Maydis, Rhizoma Dioscoreae Nipponicae 3-5 part, Rhizoma Polygonati 1-3 part, Rhizoma Chuanxiong, Fructus Corni, each 1-2 part of Fructus Rosae Laevigatae, process Hirudo 0.3-1 part.Preferably, Radix Astragali, give birth to Semen Coicis, each 3 parts of Stigma Maydis, 4 parts of Rhizoma Dioscoreae Nipponicae, 2 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1 part of Fructus Rosae Laevigatae, process 0.3 part of Hirudo.
Embodiment 1
Radix Astragali, give birth to Semen Coicis, each 2 parts of Stigma Maydis, 5 parts of Rhizoma Dioscoreae Nipponicae, 1 part of Rhizoma Polygonati, Rhizoma Chuanxiong, Fructus Corni, each 2 parts of Fructus Rosae Laevigatae, process 0.3 part of Hirudo.
Embodiment 2
Radix Astragali, give birth to Semen Coicis, each 2.2 parts of Stigma Maydis, 4.8 parts of Rhizoma Dioscoreae Nipponicae, 1.2 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.9 parts of Fructus Rosae Laevigatae, process 0.4 part of Hirudo.
Embodiment 3
Radix Astragali, give birth to Semen Coicis, each 2.4 parts of Stigma Maydis, 4.5 parts of Rhizoma Dioscoreae Nipponicae, 1.4 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.8 parts of Fructus Rosae Laevigatae, process 0.5 part of Hirudo.
Embodiment 4
Radix Astragali, give birth to Semen Coicis, each 2.5 parts of Stigma Maydis, 4.4 parts of Rhizoma Dioscoreae Nipponicae, 1.5 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.7 parts of Fructus Rosae Laevigatae, process 0.6 part of Hirudo.
Embodiment 5
Radix Astragali, give birth to Semen Coicis, each 2.8 parts of Stigma Maydis, 4.2 parts of Rhizoma Dioscoreae Nipponicae, 1.8 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.6 parts of Fructus Rosae Laevigatae, process 0.7 part of Hirudo.
Embodiment 6
Radix Astragali, give birth to Semen Coicis, each 3 parts of Stigma Maydis, 4 parts of Rhizoma Dioscoreae Nipponicae, 2 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1 part of Fructus Rosae Laevigatae, process 0.3 part of Hirudo.
Embodiment 7
Radix Astragali, give birth to Semen Coicis, each 3.2 parts of Stigma Maydis, 3.8 parts of Rhizoma Dioscoreae Nipponicae, 2.2 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.5 parts of Fructus Rosae Laevigatae, process 0.8 part of Hirudo.
Embodiment 8
Radix Astragali, give birth to Semen Coicis, each 3.5 parts of Stigma Maydis, 3.6 parts of Rhizoma Dioscoreae Nipponicae, 2.5 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.4 parts of Fructus Rosae Laevigatae, process 0.9 part of Hirudo.
Embodiment 9
Radix Astragali, give birth to Semen Coicis, each 3.6 parts of Stigma Maydis, 3.5 parts of Rhizoma Dioscoreae Nipponicae, 2.6 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.3 parts of Fructus Rosae Laevigatae, process 1 part of Hirudo.
Embodiment 10
Radix Astragali, give birth to Semen Coicis, each 3.8 parts of Stigma Maydis, 3.2 parts of Rhizoma Dioscoreae Nipponicae, 2.8 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.2 parts of Fructus Rosae Laevigatae, process 0.3 part of Hirudo.
Embodiment 11
Radix Astragali, give birth to Semen Coicis, each 4 parts of Stigma Maydis, 3 parts of Rhizoma Dioscoreae Nipponicae, 3 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1.1 parts of Fructus Rosae Laevigatae, process 1 part of Hirudo.
The preparation of embodiment 12 Chinese medicine composition decoctions
Adopt the manufacture method of Chinese medicine decoction routine, namely get the arbitrary described Chinese medicine composition of embodiment 1-11 and decoct with water into decoction.
The preparation of embodiment 13 Chinese medicine composition tablets/capsules
Get the arbitrary described Chinese medicine composition of embodiment 1-11, add 6-10 times of water gaging, decocted 1-3 hour, leach medicine juice.Add 6-10 times of water gaging again, decocted 0.5-2 hour, leach medicine juice, merge the secondary decocting liquid, leave standstill, the leaching supernatant concentrates, and puts coldly, adds concentrated solution 2-3 and doubly measures ethanol, stirs precipitation and spends the night.Get supernatant, be concentrated into thick extractum; Add pharmaceutical aids, vacuum drying is pulverized and is granulated, and is pressed into tablet or fills encapsulated.
The preparation of embodiment 14 Chinese medicine composition composition granules
Get the arbitrary described Chinese medicine composition of embodiment 1-11, add 10 times of water gagings, decocted 2 hours, leach medicine juice.Add 8 times of water gagings again, decocted 1 hour, leach medicine juice, merge the secondary decocting liquid, leave standstill, the leaching supernatant concentrates, and puts coldly, adds 2 times of amounts of concentrated solution ethanol, stirs precipitation and spends the night.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids, granulate, drying, granulate gets granule, packing 5g/ bag.
The preparation of embodiment 15 Chinese medicine composition mixture/oral liquid/syrups
Get the arbitrary described Chinese medicine composition of embodiment 1-11, add 10 times of water gagings, decocted 2 hours, leach medicine juice.Add 8 times of water gagings again, decocted 1 hour, leach medicine juice, merge the secondary decocting liquid, leave standstill, the leaching supernatant concentrates, and puts coldly, adds 2 times of amounts of concentrated solution ethanol, stirs precipitation and spends the night.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids (white sugar, Mel, benzene first propanoic acid or ethyl hydroxybenzoate etc.), make mixture, oral liquid or syrup.
Embodiment 16 clinical trials
1. data and method
1.1 physical data
Male 66 examples in this group case, women 81 examples at 53.84 ± 11.586 years old age during first visit, have been taken depressor 108 examples, 39 examples of not taken medicine.31 examples were once done examination of ocular fundus, normal 9 examples wherein, 1 grade of 5 example of ocular fundus arteriosclerosis, 2 grade of 17 example.Ultrasonic examination: fatty liver 77 examples, cholelithiasis 25 examples, renal calculus 6 examples, cyst of kidney 24 examples, hepatic cyst 13 examples, renal atrophy 2 examples, hydronephrosis 1 example.BMI:27.1958±15.8493。Hypertensive disease is 7.21 ± 8.176 years when albuminuria or microalbuminuria occurring, wherein finds hypertension time＜4 year 56 examples, 4-5 21 examples, 6-10 29 examples, 11-20 28 examples, 21-41 13 examples.Routine urianlysis has leukocyte, erythrocyte person to get rid of it, clearly has constitutional nephropathy, rheumatism etc. also to get rid of it.6 months courses for the treatment of are to 14 years, average 5.54 ± 3.42 years.
1.2 Therapeutic Method:
1.2.1 the Chinese medicine strengthening spleen, tonifying kidney, the removing dampness blood stasis dispelling.
Chinese medicine composition of the present invention (with reference to embodiment 6 and 12 preparations), every day, potion was decocted in water for oral dose.Find that urine protein positive begins to take, urine protein is turned out cloudy and is withdrawn after two weeks, repeats after the positive again to take.
1.2.2 life style intervention and psychological counseling
All patients all give life style intervention and psychological counseling: smoking cessation limit wine, and meat and vegetables is reasonably combined, light diet, appropriate exercise, the control body weight alleviates stress, maintains one's mental balance, and and guides enforcement to patient propaganda and education repeatedly according to the hypertension prevention and control guide,
1.2.3 western medicine of depressurization uses
All patients all give the treatment of oral western medicine depressor.Western medicine of depressurization commonly used such as calcium ion antagonist amlodipine, Levamlodipine, felodipine, Nifedipine sustained release tablets etc., angiotensin converting enzyme inhibitor enalapril, benazepril, fosinopril etc., angiotensin receptor antagonist valsartan, losartan, irbesartan, telmisartan etc. are if blood pressure can not up to standardly also cooperate diuretic, beta-blocker in case of necessity.
1.2.4 hypoglycemic fat-regulating treatment
Diabetes, hyperlipemia person are all given blood sugar lowering, transfer the fat treatment.
1.3 curative effect is judged
1.3.1 efficacy of antihypertensive treatment criterion
With reference to Ministry of Public Health " new Chinese medicine clinical research guideline ", ⑴ produce effects: 1. more than the diastolic pressure decline 10mmHg, and reach normal range; Though 2. diastolic pressure be not down to normally descended 20mmHg or more than.⑵ effective: 1. diastolic pressure descends not as good as 10mmHg, but has reached normal range; 2. decline 10-19mmHg before diastolic pressure is treated, but do not reach normal range; 3. systolic pressure is more than the preceding decline 30mmHg for the treatment of; ⑶ invalid: do not reach above standard person.
1.3.2 blood pressure compliance rate
Accompanying kidney damage, glycosuria patient＜130/80mmHg, over-65s old man＜150/90mmHg with reference to 2010 editions " Chinese hypertension prevention and control guide " blood pressure＜140/90mmHg, hypertension is that blood pressure is up to standard.
1.3.3 hypertensive nephropathy criterion of therapeutical effect
Hypertensive nephropathy does not still have clear and definite criterion of therapeutical effect at present, so formulate with reference to the curative effect determinate standard of hypertension, chronic renal insufficiency criterion of therapeutical effect and bibliographical information diabetic nephropathy in " new Chinese medicine clinical research guideline ".
Produce effects: urine protein, microdose urine protein are turned out cloudy, and renal insufficiency person serum creatinine descends 〉=20%.
Effectively: urine protein descends+, microdose urine protein descends 〉=30%, renal insufficiency person serum creatinine descends 〉=10%.
Invalid: as not reach effective standard or deterioration.
1.4 statistical method
Adopt the SPSS13.0 statistical software, The data mean ± standard deviation (X ± S) expression, check with t by enumeration data.
2 results:
2.1 the variation of routine urianlysis albuminuria sees Table 1 before and after the treatment.
Routine urinalysis detects urine protein positive person 140 examples, treatment back produce effects 105 examples, effective 13 examples, total effective rate 84.29%.Urine protein from ± extremely ++ all have in various degree and turn out cloudy after+the treatment, total negative conversion rate is 75%.Negative conversion rate and the urine protein order of severity are inversely proportional to, and the more light negative conversion rate of urine protein degree is more high, and ± negative conversion rate reaches 89.71%, and +++only 12.5%.There is not significant correlation with hypertensive disease, find 56 routine patients of hypertension time＜4 year, its urine protein ± ,+, ++, +++28,15,7,4 examples are arranged respectively, there is 25,13,2,1 example to turn out cloudy after the treatment respectively, negative conversion rate is compared no significant difference with whole cases.
The routine urianlysis albuminuria changes (n=140) before and after table 1. treatment
2.1 microdose urine protein changes this group patient and detects microdose urine protein and treatment cross-reference person totally 26 examples are arranged before and after the treatment, wherein 7 examples routine urinalysis detection albumen feminine gender repeatedly.Microdose urine protein is 196.0265 ± 129.1398 before the treatment, is 89.7362 ± 71.8145 after the treatment, and difference has significance (P＜0.001) before and after the treatment, wherein 9 example treatment backs are normal, and 8 routine measured values reduce more than 50%, 3 routine decline 30-49%, 4 examples descend and raise before＜30%, 2 examples are treated.Total negative conversion rate is 34.62%, total effective rate 76.92%.
2.3 changing, renal function looks into renal function serum creatinine rising person 22 examples, male 18 examples, and women 4 examples, serum creatinine 115 ~ 133umol/L is 10 examples, 134 ~ 265.2umol/L is 12 examples.Treatment back produce effects 13 examples, effective 5 examples, invalid 4 examples, total effective rate 81.82%.Wherein 14 examples are down to normal range, and 2 examples raise.
2.4 blood pressure compliance rate treatment back blood pressure person's 57 examples up to standard, compliance rate is 38.78%.41 routine BP＜140/90mmHg are still arranged in addition, and both summations are 95 examples, account for 64.63% of patient's sum.
2.5 efficacy of antihypertensive treatment produce effects 86 examples, effective 43 examples, total effective rate 87.76%.
3 discuss
According to the diagnostic criteria of Wang Haiyan " nephrology " hypertensive nephropathy, the persistence microalbuminuria in lysis, occurs or gently arrive the moderate albuminuria when making a definite diagnosis patients with hypertension, or when Clinical symptoms such as glomerule functional lesion occurring, should consider the diagnosis of hypertensive renal damage.We find albuminuria or microalbuminuria person's 202 examples in 1104 routine patients with hypertension, incidence rate is 18.30%, and this is long with patient's course of disease and find that the standard treatment is not relevant after the hypertension.Find hypertensive disease 7.21 ± 8.176 years when albuminuria appears in the 147 routine patients that accept therapy of combining Chinese and Western medicine, wherein patient's course of disease of 61.9% is more than 4 years.
The hyperpietic often occurs microdose urine protein earlier and raises, and just intermittently occurs albuminuria afterwards, and is untimely as if controlling, the sustainable existence of albuminuria.The microdose urine protein positive that only begun or urine protein be qualitative ± time, not have obvious clinical symptoms more, or non-specific performances such as dizzy, headache, tinnitus are only arranged, can occurring of continuing, nocturia increased, edema, weak etc.Comprehensive four diagnostic methods gained, this type of patient belongs under the hepatic and renal YIN deficiency more and drawing in kidney, and kidney loses the duty of envelope Tibetan, or spleen kidney yang (gas) void, and astringency inducing is had no right, and lets out under precise and tiny.Or accompany excessive rising of liver-YANG, the turbid damp-heat gluing each other of expectorant, and blood stasis or stagnant heat retardance etc., suffering from a deficiency of the kidney with spleen, to decrease be the pathological changes principal contradiction.We formulate basic side's strengthening spleen, tonifying kidney thus, the removing dampness blood stasis dispelling, and it is strong to make every effort to the spleen renal function, precise and tiny astringency inducing, the humidifying stagnation resolvation, with the control albuminuria, the protection renal function.It is 75% that the back routine urinalysis of taking medicine detects the total negative conversion rate of urine protein, total effective rate 84.29%.The total negative conversion rate of microdose urine protein is 34.62%, total effective rate 76.92%.And renal function has obtained obvious improvement.
About blood pressure compliance rate and blood pressure lowering effective percentage.This group blood pressure compliance rate is 38.78%, and 41 routine BP＜140/90mmHg are still arranged in addition, and both summations account for 64.63% of patient's sum.Sum up 555 routine hyperpietic's compliance rates 77.66% far below us.And with reference to Ministry of Public Health " new Chinese medicine clinical research guideline " criterion of therapeutical effect, blood pressure lowering total effective rate 87.76%.Similar with 555 hyperpietic's total effective rates 89.19%, but hypertension and kidney damage and glycosuria patient often need just can obtain effect with more depressor, bigger dosage.Hypertension companion kidney damage, glycosuria patient blood pressure lowering target are lower, and blood pressure lowering treatment sensitivity be can not show a candle to no kidney damage and glycosuria patient, so difficulty up to standard is bigger.This on the one hand may be relevant with the renin angiotensin aldosterone system activity, also influenced selection and the application of medicine in addition because of kidney damage, diabetes.
From clinical curative effect analysis, urine protein negative conversion rate and the urine protein order of severity are inversely proportional to, and the more light negative conversion rate of urine protein degree is more high, and urine protein ± negative conversion rate reaches 89.71%, urine protein +++negative conversion rate only 12.5%.And also more easy recovery is normal after the more low treatment of serum creatinine value.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and replenish, these improvement and replenish and also should be considered as protection scope of the present invention.
Claims (4)
1. treat hypertension and albuminuretic Chinese medicine composition for one kind, it is characterized in that, made by following bulk drugs: Radix Astragali, give birth to Semen Coicis, each 2-4 part of Stigma Maydis, Rhizoma Dioscoreae Nipponicae 3-5 part, Rhizoma Polygonati 1-3 part, Rhizoma Chuanxiong, Fructus Corni, each 1-2 part of Fructus Rosae Laevigatae, process Hirudo 0.3-1 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, made by following bulk drugs: Radix Astragali, give birth to Semen Coicis, each 2.5-3.5 part of Stigma Maydis, Rhizoma Dioscoreae Nipponicae 3.5-4.5 part, Rhizoma Polygonati 1.5-2.5 part, Rhizoma Chuanxiong, Fructus Corni, each 1-1.5 part of Fructus Rosae Laevigatae, process Hirudo 0.3-0.8 part.
3. Chinese medicine composition according to claim 1 is characterized in that, is made by following bulk drugs: Radix Astragali, give birth to Semen Coicis, each 3 parts of Stigma Maydis, 4 parts of Rhizoma Dioscoreae Nipponicae, 2 parts of Rhizoma Polygonatis, Rhizoma Chuanxiong, Fructus Corni, each 1 part of Fructus Rosae Laevigatae, process 0.3 part of Hirudo.
4. according to the application of the arbitrary described Chinese medicine composition of claim 1-3 in preparation treatment hypertension and albuminuretic medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310287511.1A CN103341081B (en) | 2013-07-10 | 2013-07-10 | Traditional Chinese medicine composition for treating hypertension and proteinuria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310287511.1A CN103341081B (en) | 2013-07-10 | 2013-07-10 | Traditional Chinese medicine composition for treating hypertension and proteinuria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103341081A true CN103341081A (en) | 2013-10-09 |
| CN103341081B CN103341081B (en) | 2014-07-30 |
Family
ID=49275941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310287511.1A Active CN103341081B (en) | 2013-07-10 | 2013-07-10 | Traditional Chinese medicine composition for treating hypertension and proteinuria |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103341081B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341082A (en) * | 2013-07-10 | 2013-10-09 | 太仓市中医医院 | Application of Chinese medicine composition in preparation of medicine used for treating hypertension and proteinuria |
| CN104274728A (en) * | 2014-10-21 | 2015-01-14 | 上海市闸北区社区卫生服务管理中心 | Traditional Chinese medicine composition for treatment of hypertension and proteinuria |
| CN109223992A (en) * | 2018-09-30 | 2019-01-18 | 杨茗橘 | It is a kind of prevent and treat albuminuria Chinese medicine composition and its application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341082A (en) * | 2013-07-10 | 2013-10-09 | 太仓市中医医院 | Application of Chinese medicine composition in preparation of medicine used for treating hypertension and proteinuria |
-
2013
- 2013-07-10 CN CN201310287511.1A patent/CN103341081B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341082A (en) * | 2013-07-10 | 2013-10-09 | 太仓市中医医院 | Application of Chinese medicine composition in preparation of medicine used for treating hypertension and proteinuria |
Non-Patent Citations (2)
| Title |
|---|
| 施卿卿: "黄春林教授妙用中药治疗蛋白尿血尿经验摭拾", 《中医药学刊》, vol. 20, no. 2, 30 April 2002 (2002-04-30), pages 157 - 159 * |
| 施进宝等: "糖尿病肾病的中医药治疗进展", 《中国中医药现代远程教育》, vol. 8, no. 23, 31 December 2010 (2010-12-31), pages 165 - 166 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341082A (en) * | 2013-07-10 | 2013-10-09 | 太仓市中医医院 | Application of Chinese medicine composition in preparation of medicine used for treating hypertension and proteinuria |
| CN103341082B (en) * | 2013-07-10 | 2014-07-30 | 太仓市中医医院 | Application of Chinese medicine composition in preparation of medicine used for treating hypertension and proteinuria |
| CN104274728A (en) * | 2014-10-21 | 2015-01-14 | 上海市闸北区社区卫生服务管理中心 | Traditional Chinese medicine composition for treatment of hypertension and proteinuria |
| CN109223992A (en) * | 2018-09-30 | 2019-01-18 | 杨茗橘 | It is a kind of prevent and treat albuminuria Chinese medicine composition and its application |
| CN109223992B (en) * | 2018-09-30 | 2021-07-06 | 上海复活石医药科技有限公司 | Traditional Chinese medicine composition for preventing and treating proteinuria and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103341081B (en) | 2014-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102228536B (en) | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof | |
| CN101607006B (en) | Application of Chinese medicinal composition in preparing medicament for treating hypertension | |
| CN100518776C (en) | Health protection tea for reducing blood pressure, and blood fat, and preparation method | |
| CN103341081B (en) | Traditional Chinese medicine composition for treating hypertension and proteinuria | |
| CN102102079A (en) | Blood pressure-reducing table vinegar and preparation method thereof | |
| CN103341082B (en) | Application of Chinese medicine composition in preparation of medicine used for treating hypertension and proteinuria | |
| CN104721467B (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof | |
| CN107281386B (en) | Method for preparing medicine for treating hypertension by using dendrobium officinale and radish seeds and application | |
| CN102631425B (en) | Mongolian medicine for treating dyslipidemia | |
| CN103211996A (en) | Preparation method of traditional Chinese medicine for treating diabetes mellitus | |
| CN100360161C (en) | Chinese medicine for treating diabets and nephritis | |
| CN103479763B (en) | Traditional Chinese medicine composition for treating borderline hypertension and preparation method thereof | |
| CN103768129B (en) | Drug composition for preventing or treating hypertension | |
| CN108042710B (en) | Traditional Chinese medicine composition for treating qi-yin deficiency and damp-heat internal accumulation type 2 diabetes and application thereof | |
| CN101632780B (en) | Application of Chinese medicinal composition in preparing medicament for treating diabetic nephropathy | |
| CN101987130A (en) | Traditional Chinese medicine compound preparation for treating early hypertension kidney damage | |
| CN103230552A (en) | Traditional Chinese medicine for treating diabetes mellitus | |
| CN101879227B (en) | Chinese medicinal composition for treating protrusion of lumbar intervertebral disci and preparation method thereof | |
| CN102247515A (en) | Traditional Chinese medicine compound preparation used for treating diabetic nephropathy, and preparation method thereof | |
| CN105288410A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and application of traditional Chinese medicine composition | |
| CN101391062B (en) | Traditional Chinese medicine preparation for treating nephritis | |
| CN100546598C (en) | A kind of oral liquid of eliminating hydrops and promoting graft function | |
| CN104001077A (en) | Traditional Chinese medicine composition for treating urinary tract infection and application thereof | |
| CN102988635A (en) | Nifedipine-containing medicinal composition | |
| CN101940666B (en) | Traditional Chinese medicine composite for treating hyperlipoidemia and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |