CN103340874B - The application of Myriberine A in the anti-aseptic inflammation medicine of preparation - Google Patents
The application of Myriberine A in the anti-aseptic inflammation medicine of preparation Download PDFInfo
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- CN103340874B CN103340874B CN201310331712.7A CN201310331712A CN103340874B CN 103340874 B CN103340874 B CN 103340874B CN 201310331712 A CN201310331712 A CN 201310331712A CN 103340874 B CN103340874 B CN 103340874B
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- Prior art keywords
- myriberine
- inflammation
- swelling
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- AVUOIHDZVXMQNT-LGEZUQEUSA-N myriberine a Chemical compound C([C@@H]1CCC2)N3CCCC[C@H]3N3[C@@H]1[C@@H]2C[C@H]1CC(=O)C=C13 AVUOIHDZVXMQNT-LGEZUQEUSA-N 0.000 title claims abstract description 78
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 16
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000003814 drug Substances 0.000 title claims description 6
- 150000001875 compounds Chemical class 0.000 abstract description 11
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 7
- 239000002260 anti-inflammatory agent Substances 0.000 abstract description 6
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 230000008961 swelling Effects 0.000 description 19
- 241000700159 Rattus Species 0.000 description 13
- 210000002683 foot Anatomy 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 9
- 230000002401 inhibitory effect Effects 0.000 description 9
- 229920001817 Agar Polymers 0.000 description 8
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 8
- 239000008272 agar Substances 0.000 description 8
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical group CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 5
- 238000003304 gavage Methods 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241001540861 Mycetia faberi Species 0.000 description 3
- 229930013930 alkaloid Natural products 0.000 description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 description 3
- 210000005069 ears Anatomy 0.000 description 3
- 240000001307 Myosotis scorpioides Species 0.000 description 2
- 208000005141 Otitis Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 210000000078 claw Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 108010084652 homeobox protein PITX1 Proteins 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (1)
- The application of 1.Myriberine A in the anti-aseptic inflammation medicine of preparation, described compound Myriberine A structure is as shown in formula I:
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310331712.7A CN103340874B (en) | 2013-08-01 | 2013-08-01 | The application of Myriberine A in the anti-aseptic inflammation medicine of preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310331712.7A CN103340874B (en) | 2013-08-01 | 2013-08-01 | The application of Myriberine A in the anti-aseptic inflammation medicine of preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103340874A CN103340874A (en) | 2013-10-09 |
CN103340874B true CN103340874B (en) | 2015-09-09 |
Family
ID=49275736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310331712.7A Active CN103340874B (en) | 2013-08-01 | 2013-08-01 | The application of Myriberine A in the anti-aseptic inflammation medicine of preparation |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103340874B (en) |
-
2013
- 2013-08-01 CN CN201310331712.7A patent/CN103340874B/en active Active
Non-Patent Citations (3)
Title |
---|
Myriberine A, a New Alkaloid with an Unprecedented Heteropentacyclic Skeleton from Myrioneuron faberi;Sheng-Dian Huang等;《ORGANIC LETTERS》;20130115;第15卷(第3期);第590-593页 * |
生物碱类化合物药理作用研究进展;蒙其淼等;《时针国医国药》;20031231;第14卷(第11期);第700-702页 * |
马爱瑛.生物碱的提取与分离.《固原师专学报(自然科学)》.2006,第27卷(第3期), * |
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Publication number | Publication date |
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CN103340874A (en) | 2013-10-09 |
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Owner name: SHANGYU ZHONGTAI MEDICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ZHAO QIAOYING Effective date: 20150630 |
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Effective date of registration: 20170906 Address after: 211200 Rongchang City, Nanjing province Lishui Yong Yang Town, garden building, room 105, room 27, No. Patentee after: Bian Yuping Address before: 432900, Xiaogan, Hubei province Xiaochang County Industrial Park South Station Road three East extension Patentee before: Hubei Nuo Kete medicine company limited-liability company |
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Address after: 210000 No. 181 Hucuo North Road, Gulou District, Nanjing City, Jiangsu Province Patentee after: Bian Yuping Address before: 211200 Room 105, 27 Rongchang Garden, Yongyang Town, Lishui District, Nanjing City, Jiangsu Province Patentee before: Bian Yuping |
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Effective date of registration: 20190121 Address after: 201299 No. 4019 Chuansha Road, Chuansha Town, Pudong New Area, Shanghai Patentee after: Shanghai Tianlong Pharmaceutical Co., Ltd. Address before: 210000 No. 181 Hucuo North Road, Gulou District, Nanjing City, Jiangsu Province Patentee before: Bian Yuping |
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