CN103335875A - Production method for quality control product of blood-gas electrolyte analyzer - Google Patents

Production method for quality control product of blood-gas electrolyte analyzer Download PDF

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Publication number
CN103335875A
CN103335875A CN2013102431712A CN201310243171A CN103335875A CN 103335875 A CN103335875 A CN 103335875A CN 2013102431712 A CN2013102431712 A CN 2013102431712A CN 201310243171 A CN201310243171 A CN 201310243171A CN 103335875 A CN103335875 A CN 103335875A
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concentration
quality
control product
production method
vigour
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刘凯
常浩
淳林
刘金虎
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NANJING PERLONG MEDICAL EQUIPMENT CO Ltd
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NANJING PERLONG MEDICAL EQUIPMENT CO Ltd
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Abstract

The invention discloses a production method for a quality control product of a blood-gas electrolyte analyzer. The production method comprises the following steps of: (1) preparing a base buffer solution with set K<+>, Na<+>, Cl<-> and Ca<2+> ionic concentrations; (2) completely balancing CO2, O2 and N2 standard gases with fixed proportion and the base buffer solution in an aluminum foil bag; (3) sealing the aluminum foil bag, driving away the gases in the aluminum foil bag through hands after the base buffer solution and the standard gases are balanced, and then sealing directly after introducing suitable standard gases; and (4) after placing the aluminum foil bag for a period of time, sub-packaging the base buffer solution into small packing bags. According to the production method, the produced quality control product has relatively high uniformity and stability, the impact of air on quality control liquid and gas partial pressure is avoided, and thus the bag uniformity of the quality control product can be ensured effectively, and the quality of the quality control product is improved.

Description

A kind of production method of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product
Technical field
The present invention relates to a kind of production method of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product.
Background technology
The vim and vigour electrolyte analysis clinical it can disintegrate in the variation of acid base equilibrium and oxygen metabolism situation and osmotic pressure, in the rescue of critical patient, it is the technical process that important monitoring means vim and vigour electrolyte analysis refers to gas dissimilar in all gases, the liquid and acid and alkali substance are analyzed and monitored osmotic pressure.Traditional blood gas analyzer can detect pH (PH), partial pressure of carbon dioxide (PCO 2) and partial pressure of oxygen (O 2) wait PH/ vim and vigour project, and according to pH (PH), partial pressure of carbon dioxide (PCO 2) and partial pressure of oxygen (O 2) value calculate AB, BE, SatO 2, ContQ 2Etc. parameter.K has been added in a new generation's blood gas analysis +, Na +, Cl -, Ca 2+The plasma project.
Generally speaking, human body artery blood normal value, PH7.35～7.45, PaCO 235～45mmHg, PaO 280～100mmHg, BE ± 3mmol, TCO 224～32mmol/L, K +3.6～5.5mmol/L, Na +135-145mmol/L, Cl -96～108mmol/L, Ca 2+Neonate 1.08～1.18mmol/L; Adult 1.12～1.23mmol/L; 60 years old 1.13 – 1.30mmol/L.The body fluid environment of human body must have the potential of hydrogen of adaptation, just can keep normal metabolism and physiological activity.The vim and vigour electrolyte analysis is used for oxygenation, ventilatory function, acid-base status and the colloidal osmotic pressure of mensuration and evaluate patient, understanding the variation of patient's the every index of blood, acid base equilibrium state and colloidal osmotic pressure by the vim and vigour electrolyte analysis, is the important reference that the clinician gives treatment to critical patient.
The detection of quality-control product is the main means of confirming instrument state as the main method of the indoor quality control of clinical labororatory.The quality-control product overwhelming majority who is used for the vim and vigour blomelicalbloodgasandelectrolrteanalyzers is import reagent, is divided into high value, intermediate value and three levels of low value, and as daily consumables, it is expensive, delivery date is longer, has seriously increased cost.
At present, the domestic method of still not having the production of vim and vigour electrolyte quality-control product, domestic traditional pH/ vim and vigour project (pH, PCO 2, PO 2) the method for blood gas analysis quality-control product be mainly: produce aqua buffer solution, principal ingredient is phosphate buffer, then balance CO 2, O 2Carry out can, envelope bottle with nitrogen, and with the high, medium and low three kinds of levels of red, yellow, blue mark.
PH/ vim and vigour project (pH, the PCO of tradition blood gas analyzer 2, PO 2) the production method of quality-control product be mainly three steps:
(1) joins control liquid;
(2) be filled to the control liquid for preparing in the ampoule bottle that is full of air by pipeline or install the balance gas that another prepares additional
The body pipeline feeds simultaneously; Or in ampoule bottle, at first charge into calibrating gas and drive air away, adding control liquid;
(3) after control liquid is filled to predetermined, carry out the thermal-flame encapsulation.
The quality-control product that adopts above method to produce, be difficult to avoid the influence of environment, thermal-flame seals and makes this be destroyed with two of gas-liquids that reach balance, can cause the variation of expection gas concentration in the quality-control product bottle, causes the variation of product quality and influences the homogeneity of product.
In sum, pH/ vim and vigour project (pH, PCO have been integrated 2, PO 2) and electrolyte project (K +, Na +, Cl -, Ca 2+) dependable performance, the vim and vigour electrolyte control liquid of homogeneous, meet the development trend of domestic quality-control product.
Summary of the invention
Goal of the invention: the object of the present invention is to provide a kind of production method that is applicable to polytype vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product, can produce homogeneity and stability than the better control liquid of classic method.The quality-control product that production obtains can carry out daily quality monitoring at vim and vigour and electrolyte project, and the control liquid that is encapsulated in the aluminium foil bag has than the better homogeneity of classic method and stability.
Technical scheme: in order solving the problems of the technologies described above, to the invention provides a kind of production method of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product, to comprise the steps:
(1) the basic damping fluid of K+, Na+, Cl-, Ca2+ ion concentration is set in preparation; This basis damping fluid is HEPES – HEPESNa buffer system, and compound concentration is that the KCl solution of 2mmol/L～6mmol/L, NaCl solution, the concentration that concentration is 80mmol/L～130mmol/L are the CaCl of 0.5mmol/L～1.5mmol/L 2Solution, concentration are the NaHCO of 4mmom/L～30mmol/L 3Solution;
(2) with the CO of preset proportion 2, O 2And N 2Calibrating gas and basic damping fluid carry out abundant balance in aluminium foil bag;
(3) aluminium foil bag seals, treat basic damping fluid and calibrating gas balance after, catch up with gas in the most aluminium foil bag with hand, feed proper standard gas direct sealing then again.
(4) aluminium foil bag is placed 72h for 25 ℃, more basic damping fluid branch is installed in the small package bag.
HEPES – HEPESNa buffer system described in the step (1), HEPES – HEPESNa concentration is 10mmol/L～40mmol/L, and KCl concentration is 5mmol/L～6mmol/L, and NaCl concentration is 100mmol/L～115mmol/L, CaCl 2Concentration is 1.1mmol/L – 1.4mmol/L, NaHCO 3Concentration is 25mmom/L～30mmol/L.
HEPES – HEPESNa buffer system described in the step (1), HEPES – HEPESNa concentration is respectively 20mmol/L～30mmol/, and KCl concentration is 3mmol/L～4mmol/L, and NaCl concentration is 90mmol/L～99mmol/L, CaCl 2Concentration is 0.9mmol/L～1mmol/L, NaHCO 3Concentration is 10mmom/L～25mmol/L.
HEPES – HEPESNa buffer system described in the step (1), HEPES – HEPESNa concentration is respectively 30mmol/L and 20mmol/L, and KCl concentration is 2mmol/L～3mmol/L, and NaCl concentration is 80mmol/L～90mmol/L, CaCl 2Concentration is 0.5mmol/L～0.7mmol/L, NaHCO 3Concentration is 4mmom/L～15mmol/L.
In the calibrating gas percent by volume of step (2), CO 2Ratio be 6%～9%, O 2Ratio be 8% – 10%, remaining is N 2
In the calibrating gas percent by volume of step (2), CO 2Ratio be 5%～8%, O 2Ratio be 12%～14%, remaining is N 2
In the calibrating gas percent by volume of step (2), the ratio of CO2 is 1.5%～2%, O 2Ratio be 16%～20%, remaining is N 2
Divide in the process of assembling in step (4), lack ingress of air as far as possible, it is fast that transfer velocity is wanted, and operates in the constant temperature and humidity workshop.
Beneficial effect: the production technology scheme of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product provided by the invention, consider the needs that clinical Quality Control is tested fully, made many optimizations at traditional processing technology, as follows:
(1) after basic damping fluid adds in the aluminium foil bag, utilize water-bath to be preheating to 37 ℃, in water-bath, feed calibrating gas then, allow the abundant balance of basic damping fluid and calibrating gas, thereby avoid effectively that partial pressure departs from expection concentration with variation of temperature in the vapor liquid equilibrium process, thereby guarantee that the quality-control product of producing has homogeneity and stability preferably.
(2) aluminium foil bag encapsulation process is caught up with most first pass gas after charging into calibrating gas, treats to catch up with again behind the vapor liquid equilibrium gas in the most aluminium foil bag, refills directly and shuts with the capping machine gland.Avoid air that the control liquid partial pressure is exerted an influence, thereby effectively guaranteed homogeneity between the bag of quality-control product, improved the quality of quality-control product.
Embodiment
The production method of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product plays a decisive role to the quality of quality-control product.High, medium and low three special quality control product, wherein pH, PCO 2, PO 2, K +, Na +, Cl -, Ca 2+Concentration have nothing in common with each other the crucial concentration of basic damping fluid and the ratio of calibrating gas of being of preparation.Because vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product has three kinds of specifications of high, medium and low level, do further explanation below in conjunction with the present invention of embodiment.
1. high-level quality-control product, prepare basic damping fluid and calibrating gas principal ingredient and concentration such as following table 1:
Table 1
Figure BDA00003363097400041
2. horizontal quality-control product in, prepare basic damping fluid and calibrating gas principal ingredient and concentration such as following table 2:
Table 2
Figure BDA00003363097400042
3. low-level quality-control product, prepare basic damping fluid and calibrating gas principal ingredient and concentration such as following table 3:
Table 3
Composition Concentration/ratio Unit
HEPES – HEPESNa buffer system 50 mmol/L
KCl 5—6 mmol/L
NaCl 100—115 mmol/L
CaCl 2 1.1—1.4 mmol/L
NaHCO 3 25—30 mmol/L
CO 2 6%—9% —
O 2 8%—10% —
N 2 All the other —
Embodiment 1
Production craft step is as follows:
(1) preparation control liquid, its basic damping fluid and calibrating gas principal ingredient and concentration are as follows:
Composition Concentration/ratio Unit
HEPES – HEPESNa buffer system 50/1：4 mmol/L
KCl 2.1 mmol/L
NaCl 83 mmol/L
CaCl 2 0.54 mmol/L
NaHCO 3 15 mmol/L
CO 2 1.96% —
O 2 20% —
N 2 All the other —
(2) under 37 ℃, calibrating gas and basic damping fluid are carried out sufficient vapor liquid equilibrium in aluminium foil bag, its aluminium foil bag utilizes the water-bath insulation.
(3) aluminium foil bag encapsulation process will drain the gas that dashes for the first time during inflation, treats the gas in the last aluminium foil bag to be drained behind the vapor liquid equilibrium, feeds again then until balance again.
Packaged quality-control product detects at the full-automatic blood gas analyzer of NOVA, and performance is as follows:
Project The target value Scope 2SD Unit
pH 7.590 7.582-7.623 0.015 —
P?CO 2 24.3 20.9-26.0 1.9 mmHg
P?O 2 150.4 135.5-152.8 2.0 mmHg
K + 2.1 1.98-2.21 0.012 mmol/L
Na + 113.4 110.0-118.1 1.0 mmol/L
Cl - 86.4 80.0-89.3 2.0 mmol/L
Ca 2+ 0.55 0.46-0.66 0.05 mmol/L
The quality-control product that adopts above method to produce, performance have reached the requirement of expection, can be used for indoor quality control.
Embodiment 2:
Production craft step is as follows:
(1) preparation control liquid, its basic damping fluid and calibrating gas principal ingredient and concentration are as follows:
Composition Concentration/ratio Unit
HEPES – HEPESNa buffer system 50/2：3 mmol/L
KCl 3.9 mmol/L
NaCl 93 mmol/L
CaCl 2 0.95 mmol/L
NaHCO 3 25 mmol/L
CO 2 6% —
O 2 13% —
N 2 All the other —
(2) under 37 ℃, calibrating gas and basic damping fluid are carried out sufficient vapor liquid equilibrium in aluminium foil bag, its aluminium foil bag utilizes the water-bath insulation.
(3) aluminium foil bag encapsulation process will drain the gas that dashes for the first time during inflation, treats the gas in the last aluminium foil bag to be drained behind the vapor liquid equilibrium, feeds again then until balance again.
Packaged quality-control product detects at the full-automatic blood gas analyzer of NOVA, and performance is as follows:
Project The target value Scope 2SD Unit
pH 7.390 7.382-7.403 0.016 —
P?CO 2 39.3 37.9-43.0 1.8 mmHg
P?O 2 103.4 97.5-110.8 2.4 mmHg
K + 3.94 3.68-4.21 0.013 mmol/L
Na + 138.4 131.0-141.1 1.1 mmol/L
Cl - 97.4 93.0-101.3 2.0 mmol/L
Ca 2+ 0.95 0.89-1.05 0.06 mmol/L
The quality-control product that adopts above method to produce, performance have reached the requirement of expection, can be used for indoor quality control.
Embodiment 3
Production craft step is as follows:
(1) preparation control liquid, its basic damping fluid and calibrating gas principal ingredient and concentration are as follows:
Composition Concentration/ratio Unit
HEPES – HEPESNa buffer system 50/3：2 mmol/L
KCl 5.4 mmol/L
NaCl 110 mmol/L
CaCl 2 1.30 mmol/L
NaHCO 3 30 mmol/L
CO 2 8% —
O 2 9% —
N 2 All the other —
(2) under 37 ℃, calibrating gas and basic damping fluid are carried out sufficient vapor liquid equilibrium in aluminium foil bag, its aluminium foil bag utilizes the water-bath insulation.
(3) aluminium foil bag encapsulation process will drain the gas that dashes for the first time during inflation, treats the gas in the last aluminium foil bag to be drained behind the vapor liquid equilibrium, feeds again then until balance again.
Packaged quality-control product detects at the full-automatic blood gas analyzer of NOVA, and performance is as follows:
Project The target value Scope 2SD Unit
pH 7.190 7.167-7.203 0.015 —
P?CO 2 59.3 54.9-64.0 1.8 mmHg
P?O 2 60.4 57.5-68.8 2.4 mmHg
K + 5.39 5.18-5.91 0.014 mmol/L
Na + 160.4 159.0-166.1 1.0 mmol/L
Cl - 120.4 114.0-126.3 2.0 mmol/L
Ca 2+ 1.35 1.31-1.53 0.05 mmol/L
The quality-control product that adopts above method to produce, performance have reached the requirement of expection, can be used for indoor quality control.
Embodiment 4
Production craft step is as follows:
(1) preparation control liquid, its basic damping fluid and calibrating gas principal ingredient and concentration are as follows:
Composition Concentration/ratio Unit
HEPES – HEPESNa buffer system 10 mmol/L
KCl 2 mmol/L
NaCl 80 mmol/L
CaCl 2 0.5 mmol/L
NaHCO 3 4 mmol/L
CO 2 1.5% —
O 2 16% —
N 2 All the other —
(2) under 37 ℃, calibrating gas and basic damping fluid are carried out sufficient vapor liquid equilibrium in aluminium foil bag, its aluminium foil bag utilizes the water-bath insulation.
(3) aluminium foil bag encapsulation process will drain the gas that dashes for the first time during inflation, treats the gas in the last aluminium foil bag to be drained behind the vapor liquid equilibrium, feeds again then until balance again.
Packaged quality-control product detects at the full-automatic blood gas analyzer of NOVA, and performance is as follows:
Project The target value Scope 2SD Unit
pH 7.780 7.630-7.823 0.014 —
P?CO 2 15.38 15.9-21.0 1.9 mmHg
P?O 2 158.4 165.5-155.8 1.9 mmHg
K + 1.95 1.78-2.01 0.010 mmol/L
Na + 94.4 90.4-110.1 1.0 mmol/L
Cl - 84.4 80.0-90.3 2.0 mmol/L
Ca 2+ 0.5 0.40-0.56 0.03 mmol/L
The quality-control product that adopts above method to produce, performance have reached the requirement of expection, can be used for indoor quality control.
Embodiment 5
Production craft step is as follows:
(1) preparation control liquid, its basic damping fluid and calibrating gas principal ingredient and concentration are as follows:
Composition Concentration/ratio Unit
HEPES – HEPESNa buffer system 40 mmol/L
KCl 6 mmol/L
NaCl 130 mmol/L
CaCl 2 1.50 mmol/L
NaHCO 3 40 mmol/L
CO 2 9% —
O 2 7% —
N 2 All the other —
(2) under 37 ℃, calibrating gas and basic damping fluid are carried out sufficient vapor liquid equilibrium in aluminium foil bag, its aluminium foil bag utilizes the water-bath insulation.(3) aluminium foil bag encapsulation process will drain the gas that dashes for the first time during inflation, treats the gas in the last aluminium foil bag to be drained behind the vapor liquid equilibrium, feeds again then until balance again.
Packaged quality-control product detects at the full-automatic blood gas analyzer of NOVA, and performance is as follows:
Project The target value Scope 2SD Unit
pH 7.140 7.137-7.203 0.015 —
P?CO 2 69.3 64.9-74.0 1.6 mmHg
P?O 2 70.4 67.5-78.8 1.4 mmHg
K + 6 5.88-6.41 0.012 mmol/L
Na + 170.4 169.0-186.1 1.0 mmol/L
Cl - 130.4 124.0-136.3 1.7 mmol/L
Ca 2+ 1.5 1.4-1.64 0.04 mmol/L
The quality-control product that adopts above method to produce, performance have reached the requirement of expection, can be used for indoor quality control.
Embodiment 6
The quality-control product resting period that the method obtains is long, following data be deposit 2 years after the data value that records of quality-control product:
(1) high-level quality-control product
Project The A value B value (data after 2 years)
pH 7.590 7.590
P?CO 2 24.3 24.3
P?O 2 150.4 150.4
K + 2.1 2.1
Na + 113.4 113.4
Cl - 86.4 86.4
Ca 2+ 0.55 0.55
(2) horizontal quality-control product in
Project The A value B value (data after 2 years)
pH 7.390 7.390
P?CO 2 39.3 39.3
P?O 2 103.4 103.4
K + 3.94 3.94
Na + 138.4 138.4
Cl - 97.4 97.4
Ca 2+ 0.95 0.95
(3) low-level quality-control product
Project The A value B value (data after 2 years)
pH 7.190 7.190
P?CO 2 59.3 59.3
P?O 2 60.4 60.4
K + 5.39 5.39
Na + 160.4 160.4
Cl - 120.4 120.4
Ca 2+ 1.35 1.35
From experimental data, no matter be high, the low-level quality-control product that neutralizes, the resting period reaches 2 years, measures next value all without any variation at the full-automatic blood gas analyzer of NOVA, and this effect phase that this basic damping fluid is described is longer.
In addition, added BSA and surfactant in this basic damping fluid process for preparation, this measure is in order to imitate the viscosity of blood, thereby makes instrument after using this quality-control product, can not produce deviation when measuring in real time.
The above only is preferred implementation of the present invention; be noted that for those skilled in the art; under the prerequisite that does not break away from the principle of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.

Claims (7)

1. the production method of a vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product is characterized in that, comprises the steps:
(1) K is set in preparation +, Na +, Cl -, Ca 2+The basic damping fluid of ion concentration; This basis damping fluid is HEPES – HEPESNa buffer system, and compound concentration is that the KCl solution of 2mmol/L～6mmol/L, NaCl solution, the concentration that concentration is 80mmol/L～130mmol/L are the CaCl of 0.5mmol/L～1.5mmol/L 2Solution, concentration are the NaHCO of 4mmom/L～40mmol/L 3Solution;
(2) with the CO of preset proportion 2, O 2And N 2Calibrating gas and basic damping fluid carry out abundant balance in aluminium foil bag;
(3) aluminium foil bag seals, treat basic damping fluid and calibrating gas balance after, catch up with gas in the most aluminium foil bag with hand, feed proper standard gas direct sealing then again.
(4) aluminium foil bag is placed 72h for 25 ℃, more basic damping fluid branch is installed in the small package bag.
2. the production method of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product according to claim 1, it is characterized in that, HEPES – HEPESNa buffer system described in the step (1), HEPES – HEPESNa concentration is 10mmol/L～40mmol/L, KCl concentration is 5mmol/L～6mmol/L, NaCl concentration is 100mmol/L～115mmol/L, CaCl 2Concentration is 1.1mmol/L – 1.4mmol/L, NaHCO 3Concentration is 25mmom/L～30mmol/L.
3. the production method of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product as claimed in claim 1, it is characterized in that, HEPES – HEPESNa buffer system described in the step (1), HEPES – HEPESNa concentration is respectively 20mmol/L～30mmol/, KCl concentration is 3mmol/L～4mmol/L, NaCl concentration is 90mmol/L～99mmol/L, CaCl 2Concentration is 0.9mmol/L～1mmol/L, NaHCO 3Concentration is 10mmom/L～25mmol/L.
4. the production method of vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control product according to claim 1, it is characterized in that, HEPES – HEPESNa buffer system described in the step (1), HEPES – HEPESNa concentration is respectively 30mmol/L and 20mmol/L, KCl concentration is 2mmol/L～3mmol/L, NaCl concentration is 80mmol/L～90mmol/L, CaCl 2Concentration is 0.5mmol/L～0.7mmol/L, NaHCO 3Concentration is 4mmom/L～15mmol/L.
5. according to the production method of claim 1 or 2 or 3 or 4 described vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control products, it is characterized in that, in the calibrating gas percent by volume of step (2), CO 2Ratio be 6%～9%, O 2Ratio be 8% – 10%, remaining is N 2
6. according to the production method of claim 1 or 2 or 3 or 4 described vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control products, it is characterized in that, in the calibrating gas percent by volume of step (2), CO 2Ratio be 5%～8%, O 2Ratio be 12%～14%, remaining is N 2
7. according to the production method of claim 1 or 2 or 3 or 4 described vim and vigour blomelicalbloodgasandelectrolrteanalyzers quality-control products, it is characterized in that, in the calibrating gas percent by volume of step (2), CO 2Ratio be 1.5%～2%, O 2Ratio be 16%～20%, remaining is N 2
CN2013102431712A 2013-06-18 2013-06-18 Production method for quality control product of blood-gas electrolyte analyzer Pending CN103335875A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109357697A (en) * 2018-09-29 2019-02-19 广州市康软信息科技有限公司 Medical instrument calibration method, system and device based on quality evaluation target value calculation
CN113237710A (en) * 2021-03-15 2021-08-10 南京普朗生物医学有限公司 Multi-level quality control material production method and source tracing calibration method of blood gas analyzer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013666A (en) * 1988-06-15 1991-05-07 Bionostics, Incorporated Control for blood gas/calcium analysis instrumentation
CN101308150A (en) * 2007-05-18 2008-11-19 上海丰德生物医药科技有限公司 Blood gas analyzer quality control serum production process
CN102393452A (en) * 2011-08-19 2012-03-28 上海惠中医疗科技有限公司 Production method for blood gas and electrolyte control material
CN102435724A (en) * 2011-01-04 2012-05-02 中山市滔略生物科技有限公司 Quality control material and calibrator for calibrating blood cell analyzers and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013666A (en) * 1988-06-15 1991-05-07 Bionostics, Incorporated Control for blood gas/calcium analysis instrumentation
CN101308150A (en) * 2007-05-18 2008-11-19 上海丰德生物医药科技有限公司 Blood gas analyzer quality control serum production process
CN102435724A (en) * 2011-01-04 2012-05-02 中山市滔略生物科技有限公司 Quality control material and calibrator for calibrating blood cell analyzers and preparation method thereof
CN102393452A (en) * 2011-08-19 2012-03-28 上海惠中医疗科技有限公司 Production method for blood gas and electrolyte control material

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109357697A (en) * 2018-09-29 2019-02-19 广州市康软信息科技有限公司 Medical instrument calibration method, system and device based on quality evaluation target value calculation
CN113237710A (en) * 2021-03-15 2021-08-10 南京普朗生物医学有限公司 Multi-level quality control material production method and source tracing calibration method of blood gas analyzer

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Application publication date: 20131002