CN103335507A - Sterilization cooling device for vacuum freeze drier - Google Patents
Sterilization cooling device for vacuum freeze drier Download PDFInfo
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- CN103335507A CN103335507A CN2013102519761A CN201310251976A CN103335507A CN 103335507 A CN103335507 A CN 103335507A CN 2013102519761 A CN2013102519761 A CN 2013102519761A CN 201310251976 A CN201310251976 A CN 201310251976A CN 103335507 A CN103335507 A CN 103335507A
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- cooling
- freeze drier
- silicone oil
- cooling device
- vacuum freeze
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Abstract
The invention discloses a sterilization cooling device for a vacuum freeze drier. The device is characterized by comprising a barrel, wherein end covers are arranged at the two ends of the barrel respectively; a silicone oil inlet is formed outside one end cover, and a silicone outlet is formed outside the other end cover; a pipe coil is arranged in the barrel; the two ends of the pipe coil are respectively connected with a cooling water inlet and a cooling water outlet, which are formed outside the barrel; the pipe coil is fixedly arranged in the barrel through inner pipe coil fixing end plates; a water inlet and outlet separation board is arranged between each inner pipe coil fixing end plate and the corresponding end cover; upper and lower baffle plates are arranged at intervals between the two inner pipe coil fixing end plates; and the barrel is provided with an emptying port and a sewage discharge outlet. The cooling device is combined with a silicone oil circulation system of the freeze drier for use, is more convenient to connect and use, has a remarkable sterilization cooling effect, can be efficiently and reliably used for rapidly reducing temperature after the sterilization of the freeze drier, a small area is occupied, the production cycle of a pharmaceutical factory is effectively shortened, and the yield of the pharmaceutical factory is actively and favorably improved.
Description
Technical field
The present invention relates to the vacuum freeze drier technical field, be installed on the circulatory system on the vacuum freeze drier, be mainly used in vacuum freeze drier the temperature inside the box after sterilization is reduced rapidly.
Background technology
Existing sterilization back cooling method, mainly be modes such as chuck cooling and refrigeration system cooling, the chuck cooling mainly is independent recirculated cooling water in the chuck, limited to the tank wall cool effect, especially very poor to the cooling-down effect of flaggy, the mode of walking silicone oil in the chuck is also arranged, Controllable Temperature and temperature are lower, but this cooling method has high requirements to the making of chuck, and the pressure control in the chuck is also than higher, and security decreases and actual effect does not significantly promote.Another type of cooling is that refrigeration system is lowered the temperature to the silicone oil in the flaggy, and this mode has a significant impact the refrigeration oil quality of refrigeration system especially compressor, and compressor low-pressure end hypertonia, and is more to compressor performance and life-span drawback.Also have some types of cooling often to adopt plate type heat exchanger, cost and floor space are bigger, connect inconvenience.
Summary of the invention
To be solved by this invention is technical problems such as existing cooling device is poor to the flaggy cooling-down effect, complex process, security is not high, the life-span is short.
In order to solve the problems of the technologies described above, the invention provides a kind of cooling device of the sterilization cooling for vacuum freeze drier, it is characterized in that, comprise cylindrical shell, the two ends of cylindrical shell are respectively equipped with end cap, and the outside of 2 end caps is respectively equipped with silicone oil import, silicone oil outlet; Be provided with coil pipe in the cylindrical shell, the upside two ends of cylindrical shell are respectively equipped with cooling water inlet, coolant outlet, and the two ends of coil pipe are connected with cooling water inlet, coolant outlet respectively; Coil pipe is fixed in the cylindrical shell by the inside coil pipe fixed charge method end plate at two ends in the cylindrical shell; Be provided with the Inlet and outlet water division board between every inner coil pipe fixed charge method end plate and the end cap; Be provided with overhead gage fixed mount and lower baffle plate fixed mount between 2 inner coil pipe fixed charge method end plates, the overhead gage fixed mount is provided with at least one overhead gage, and the lower baffle plate fixed mount is provided with at least one lower baffle plate; The upside of cylindrical shell is provided with evacuation port, and downside is provided with sewage draining exit.
Preferably, described silicone oil import and silicone oil outlet be not on same horizontal plane, and the silicone oil import is positioned at downside, and the silicone oil outlet is positioned at upside.
Preferably, described coil pipe inwall is provided with the helical form internal tooth, and helical angle is 18 °～23 °.
Further, described coil pipe inwall is provided with 40 internal tooths.
Preferably, the two ends of described cylindrical shell downside are respectively equipped with a supporting leg.
Preferably, described overhead gage and lower baffle plate are arranged at interval.
Preferably, the downside of described cylindrical shell is provided with liquid level and detects mouth.
Further, described sewage draining exit, liquid level detect that mouth is located at silicone oil import or silicone oil outlet and with it between immediate overhead gage or the lower baffle plate.
Preferably, described evacuation port is provided with exhaust-valve.
Preferably, described sewage draining exit is provided with blowoff valve.
The technical solution adopted in the present invention is this cooling device of series connection in the flaggy circulation branch road of freeze dryer.This cooling device is 1 shell-and-tube heat exchanger, meets standards such as " fixed safe technology of pressure vessel supervision rules ", " refrigerating plant pressure vessel ".The material of housing is 304 stainless steels, and what be different from usual shell-and-tube heat exchanger is that the material of tube side also is 304 stainless steels.Be further to improve the heat exchange effect, the coil pipe inner surface rolls tooth, forms the internal tooth of helical angle=18 °～about 23 °, 40, force silicone oil in pipe, form turbulent flow with reduce heat exchange real-time between.Tube side is three threads, and the welding manner employing of pipe and tube sheet is pasted and expanded+welding, 2 end caps is welded after the helium inspection is qualified again.
After the application of this cooler can effectively solve existing freeze dryer steam sterilizing, it is long that cool time, length caused the whole medicine production cycle of pharmaceutical factory, and then the problem of equal output decline.Maximizing helps the client to promote output, increases sales volume.And compare plate type heat exchanger, and this cooler manufacturing is simple, and cost is low, and is easy to connect, and its size shape more is applicable to the integral layout of each parts of freeze dryer, and circulation line is reserved cooler length and can directly be installed in existing layout.The cooling water outlet and inlet of cooler links to each other with the water condenser Inlet and outlet water branch road of refrigerating system of freeze dryer by automatic valve, and is provided with exhaust-valve, blowoff valve, and functions such as liquid level detection all are to realize relevant interlocking and control automatically, safety easy to use by PLC.And the feasible cooling water of being more convenient for draining enclosure interior of the structure of shell-and-tube heat exchanger, this also is the advantage of comparing other heat exchanger structures.
Description of drawings
Fig. 1 is the structural representation of the sterilization cooling device for vacuum freeze drier provided by the invention;
Fig. 2 is the schematic diagram of coil pipe;
Connection diagram when Fig. 3 uses for the present invention.
The specific embodiment
For the present invention is become apparent, now with preferred embodiment, and conjunction with figs. is described in detail below.
Embodiment
Shown in Fig. 1-2, structural representation for the cooling device of the sterilization cooling for vacuum freeze drier provided by the invention, comprise cylindrical shell 5, an end cap 2 is installed at the two ends of cylindrical shell 5 respectively, the outside of 2 end caps 2 is respectively equipped with silicone oil import 1, silicone oil outlet 16, silicone oil import 1 is positioned at downside, and silicone oil outlet 16 is positioned at upside.Be provided with coil pipe (as shown in Figure 2) in the cylindrical shell 5, the upside two ends of cylindrical shell 5 are respectively equipped with cooling water inlet 11, coolant outlet 15, and the two ends of coil pipe are connected with cooling water inlet 11, coolant outlet 15 respectively.Coil pipe is fixed in the cylindrical shell 5 by the inside coil pipe fixed charge method end plate 10 at two ends in the cylindrical shell 5.An Inlet and outlet water division board 9 is installed between every inner coil pipe fixed charge method end plate 10 and the end cap 2.Be provided with overhead gage fixed mount 12 and lower baffle plate fixed mount 6 between 2 inner coil pipe fixed charge method end plates 10,3 overhead gages 14 are installed on the overhead gage fixed mount 12,2 lower baffle plates 7 are installed on the lower baffle plate fixed mount 6, overhead gage 14 is arranged at interval with lower baffle plate 7.The upside centre position of cylindrical shell 5 is provided with evacuation port 13, following left side is provided with liquid level and detects mouth 3 and sewage draining exit 4, liquid level detects mouthfuls 3 and is located at silicone oil import 1 and with it between the immediate overhead gage 14, and sewage draining exit 4 is located at silicone oil import 1 and with it between the immediate lower baffle plate 7.Evacuation port 13 is provided with exhaust-valve; Sewage draining exit 4 is provided with blowoff valve.A supporting leg 8 is installed at the two ends of cylindrical shell 5 downsides respectively, and during use, the right side bed hedgehopping with cooling device makes things convenient for blowdown.
During use, as shown in Figure 2, silicone oil import 1 of the present invention, silicone oil outlet 16 are connected with the import and export of the freeze dryer flaggy circulatory system 17 respectively, form closed circuit; Cooling water inlet is connected with water inlet branch road 8; Coolant outlet 15 is connected with water outlet branch road 19; Liquid level detects mouth and is connected with liquid level detection device 20.Circulatory mediator in the shell side is the medium in the freeze dryer flaggy circulatory system 17: circulatory mediator is cooling water in the coil pipe tube side, and originating is the used cooling water of the water condenser of refrigeration system, and temperature is generally 5-32 ℃; Cooling water and silicone oil by low temperature carry out heat exchange, thereby the back circulatory system of will sterilizing is interior up to the near normal temperature of 120 ℃ silicone oil.Be provided with evacuation port 13 on the cylindrical shell 5 and sewage draining exit 4 is convenient to draining, in addition, for effectively detecting in the cylindrical shell 5 whether residual water is arranged, also be provided with on the cylindrical shell 5 for liquid level is installed and detect mouthfuls 3.The flow-stopping plate of cooler inside, namely overhead gage 14 and lower baffle plate 7 are convenient to improve the cooling water utilization rate.
It mainly is that cost is low that the present invention adopts the reason of tube shell type structure; Easy to connect, to reserve cooler length at circulation line and get final product, the cooling water outlet and inlet on the housing links to each other with the water condenser Inlet and outlet water branch road of refrigerating system of freeze dryer by automatic valve; Shell-and-tube heat exchanger is more convenient for draining the cooling water in the heat exchanger, and this also is simultaneously why shell side the inside medium is the reason of water.
Use of the present invention mainly divides 2 aspects
1, at the non-sterilization temperature-fall period of freeze dryer, when the circulatory system runs well, silicone oil in the freeze dryer dividing plate is no matter be in cooling or temperature rise period, this cooler only plays the circulation effect, there is not the cooling water circulation in the shell side, the water inlet branch road 18 of cooling water, water outlet branch road 19 all is equipped with autocontrol valve, control system is according to the current freeze dryer stage of living in, automatically with the valve closing on the cooling water water outlet branch road 19, simultaneously at the silicone oil of the circulatory system before the low temperature circulation, be installed on the state of liquid-level switch of the liquid level detection device 20 of housing bottom by judgement, determine whether to open the silicone oil refrigeration, if water is arranged in the housing, can't start the silicone oil refrigeration, avoiding making the cooler internal moisture to freeze, and then damage cooler.
2, at freeze dryer sterilization back cooling cooling stage, the water inlet branch road 18 of cooling water, the valve on the water outlet branch road 19 are opened automatically, and the silicone oil of the freeze dryer circulatory system circulates, carry out exchange heat with cooling water, finish the cooling of silicone oil, and then finish the freeze dryer flaggy, the cooling of tank wall.
Through theoretical analog computation and actual verification, cooling device provided by the invention drops to 35 ℃ with silicone oil from 120 ℃ only needs 3 to 4 hours, and the cooling of traditional chuck often needed 24 hours even the longer time.
Claims (10)
1. a cooling device that is used for the sterilization cooling of vacuum freeze drier is characterized in that comprise cylindrical shell (5), the two ends of cylindrical shell (5) are respectively equipped with end cap (2), and the outside of 2 end caps (2) is respectively equipped with silicone oil import (1), silicone oil outlet (16); Be provided with coil pipe (21) in the cylindrical shell (5), the upside two ends of cylindrical shell (5) are respectively equipped with cooling water inlet (11), coolant outlet (15), and the two ends of coil pipe (21) are connected with cooling water inlet (11), coolant outlet (15) respectively; Coil pipe (21) is fixed in the cylindrical shell (5) by the inside coil pipe fixed charge method end plate (10) at the interior two ends of cylindrical shell (5); Be provided with Inlet and outlet water division board (9) between every inner coil pipe fixed charge method end plate (10) and the end cap (2); Be provided with overhead gage fixed mount (12) and lower baffle plate fixed mount (6) between 2 inner coil pipe fixed charge method end plates (10), overhead gage fixed mount (12) is provided with at least one overhead gage (14), and lower baffle plate fixed mount (6) is provided with at least one lower baffle plate (7); The upside of cylindrical shell (5) is provided with evacuation port (13), and downside is provided with sewage draining exit (4).
2. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 1, it is characterized in that, described silicone oil import (1) exports (16) not on same horizontal plane with silicone oil, and silicone oil import (1) is positioned at downside, and silicone oil outlet (16) is positioned at upside.
3. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 1 is characterized in that described coil pipe (21) inwall is provided with the helical form internal tooth, and helical angle is 18 °～23 °.
4. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 3 is characterized in that described coil pipe (21) inwall is provided with 40 internal tooths.
5. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 1 is characterized in that the two ends of described cylindrical shell (5) downside are respectively equipped with a supporting leg (8).
6. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 1 is characterized in that, described overhead gage (14) is arranged at interval with lower baffle plate (7).
7. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 1 is characterized in that the downside of described cylindrical shell (5) is provided with liquid level and detects mouthful (3).
8. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 7, it is characterized in that described sewage draining exit (4), liquid level detect mouthful (3) and be located at silicone oil import (1) or silicone oil outlet (16) and with it between immediate overhead gage (14) or the lower baffle plate (7).
9. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 1 is characterized in that described evacuation port (13) is provided with exhaust-valve.
10. the cooling device of a kind of sterilization cooling for vacuum freeze drier as claimed in claim 1 is characterized in that described sewage draining exit (4) is provided with blowoff valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102519761A CN103335507A (en) | 2013-06-21 | 2013-06-21 | Sterilization cooling device for vacuum freeze drier |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102519761A CN103335507A (en) | 2013-06-21 | 2013-06-21 | Sterilization cooling device for vacuum freeze drier |
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| CN103335507A true CN103335507A (en) | 2013-10-02 |
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| CN2013102519761A Pending CN103335507A (en) | 2013-06-21 | 2013-06-21 | Sterilization cooling device for vacuum freeze drier |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103803261A (en) * | 2014-02-18 | 2014-05-21 | 芜湖市爱德运输机械有限公司 | Spiral conveyer with cooling function |
| CN109673717A (en) * | 2018-12-11 | 2019-04-26 | 湖南赤松亭农牧有限公司 | A kind of beef deep processing refrigerating plant |
| CN112611166A (en) * | 2020-12-09 | 2021-04-06 | 赤水市信天中药产业开发有限公司 | Freeze-drying device and method for preparing dendrobium nobile (dendrobium nobile) decoction pieces |
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| US20050144804A1 (en) * | 2003-12-24 | 2005-07-07 | Alstat Edward K. | Method and apparatus for reclaiming effluent from a freeze-drying process, and uses for effluent |
| JP2005524041A (en) * | 2002-04-23 | 2005-08-11 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Freeze drying device |
| CN201314766Y (en) * | 2008-12-11 | 2009-09-23 | 上海舒博拉尼制药设备有限公司 | Refrigeration controller for freezedryer |
| CN201355176Y (en) * | 2009-01-20 | 2009-12-02 | 上海舒博拉尼制药设备有限公司 | Protector capable of rapidly cooling plate layers after steam sterilizing of freeze dryer |
| CN101650138A (en) * | 2009-07-03 | 2010-02-17 | 广州联合冷热设备有限公司 | Shell-and-tube heat exchanger |
| CN202547447U (en) * | 2012-04-16 | 2012-11-21 | 嘉顿美威石油化工（天津）有限公司 | Shell and tube condenser |
| CN202942799U (en) * | 2012-09-28 | 2013-05-22 | 简明堃 | Structurally improved freezing drier |
| CN203405075U (en) * | 2013-06-21 | 2014-01-22 | 上海东富龙制药设备制造有限公司 | Vacuum freeze dryer-used sterilization cooling device |
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2013
- 2013-06-21 CN CN2013102519761A patent/CN103335507A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2005524041A (en) * | 2002-04-23 | 2005-08-11 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Freeze drying device |
| US20050144804A1 (en) * | 2003-12-24 | 2005-07-07 | Alstat Edward K. | Method and apparatus for reclaiming effluent from a freeze-drying process, and uses for effluent |
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| CN202942799U (en) * | 2012-09-28 | 2013-05-22 | 简明堃 | Structurally improved freezing drier |
| CN203405075U (en) * | 2013-06-21 | 2014-01-22 | 上海东富龙制药设备制造有限公司 | Vacuum freeze dryer-used sterilization cooling device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103803261A (en) * | 2014-02-18 | 2014-05-21 | 芜湖市爱德运输机械有限公司 | Spiral conveyer with cooling function |
| CN109673717A (en) * | 2018-12-11 | 2019-04-26 | 湖南赤松亭农牧有限公司 | A kind of beef deep processing refrigerating plant |
| CN112611166A (en) * | 2020-12-09 | 2021-04-06 | 赤水市信天中药产业开发有限公司 | Freeze-drying device and method for preparing dendrobium nobile (dendrobium nobile) decoction pieces |
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Application publication date: 20131002 |