CN103330583B - Embolism intervention catheter and application thereof - Google Patents
Embolism intervention catheter and application thereof Download PDFInfo
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- CN103330583B CN103330583B CN201310222100.4A CN201310222100A CN103330583B CN 103330583 B CN103330583 B CN 103330583B CN 201310222100 A CN201310222100 A CN 201310222100A CN 103330583 B CN103330583 B CN 103330583B
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- embolism
- heliosensitivity
- aquagel
- intervention catheter
- embolism intervention
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Abstract
The invention provides an embolism intervention catheter which comprises a group of light emitting diodes (3), and an outer tube (1) and a hollow inner tube (2) which are arranged sequentially from outside to inside, wherein the light emitting diodes (3) are arranged at one end of the embolism intervention catheter, and connected with a wire (4) arranged between the outer tube (1) and the inner tube (2). The embolism intervention catheter is simple in structure and low in cost, and an embolism agent can be changed from sol to gel after the light emitting diodes arranged at the end part illuminate the photosensitive chitosan hydrogel embolism agent in the embolism intervention catheter, so that the embolism intervention catheter has the characteristics of high integrity, good strength and good stability.
Description
Technical field
The invention belongs to biomedical devices field, particularly a kind of embolism intervention catheter, also relate to the application of this embolism intervention catheter.
Background technology
Cancer is a kind of commonly encountered diseases of serious harm human life health, and cancer finds evening, healing is difficult becomes the lethal major reason of this disease.In China, cancer has become the No.1 cause of the death of urbanite and the second largest cause of death of urban residents.Major part cancer patient belongs to middle and advanced stage when finding, has not had the chance that radical surgery is treated.Conventional cancer non-surgical treatment comprises: percutaneous angiographic embolization (Transcatheter Arterial Embolization, TAE), radiotherapy, local ablation therapy and biological immune treatment etc.Wherein, TAE uses the widest, curative effect the best way in current cancer non-operative treatment.
Interposing catheter is a kind of medical apparatus and instruments for intervention diagnosis and therapy, is especially more applied in percutaneous angiographic embolization intervention diagnosis and therapy aspect.Conventional interposing catheter can import to specific part suppository, but does not interact with suppository, and require higher to the mobility, setting time etc. of suppository, effect of embolization is bad, which limits the use of suppository.
Hydrogel is three-dimensional network between liquid and solid or interpenetrating networks, is a kind ofly to swell in water significantly but the hydrophilic polymer gel that can not dissolve in water.Progress in Intelligent Hydrogel then can have response to environmental stimulus, is study hotspot in recent years.Heliosensitivity aquagel can increase suddenly at viscosity under irradiation under ultraviolet ray, is transformed into elastic gel that is insoluble, that do not melt, have cross-linked structure, therefore in percutaneous angiographic embolization, has potential application.
Summary of the invention
Goal of the invention: the object of this invention is to provide a kind of embolism intervention catheter.
The second object of the present invention is to provide the application of above-mentioned embolism intervention catheter.
Technical scheme: a kind of embolism intervention catheter provided by the invention, described embolism intervention catheter comprises the interior pipe of one group of light emitting diode and the outer tube from outer to inner set gradually and hollow; Light emitting diode is located at embolism intervention catheter one end, and is connected with the wire arranged between outer tube and interior pipe.
As preferably, the internal diameter of described interior pipe is 1-2.5mm; The internal diameter 1-1.5mm larger than the internal diameter of interior pipe of described outer tube.
Present invention also offers a kind of vascular occluding device, comprise above-mentioned embolism intervention catheter, also comprise the suppository passed in embolism intervention catheter, described suppository is heliosensitivity aquagel.
As preferably, the structural formula of described heliosensitivity aquagel is:
The biocompatibility of this heliosensitivity aquagel is high, avoids the side effect that foreign body brings human body.
As preferred further, the preparation method of described heliosensitivity aquagel comprises the following steps:
(1) synthesis of lactose cross-linked chitosan (CH-LA): chitosan, N, N, N ', N '-tetramethylethylenediamine (TEMED), 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-O-β-D-galactose-(1,4)-maltonic acid reacts in acid condition, filter, concentrate, obtain lactose cross-linked chitosan molecule (CH-LA); (2) synthesis of heliosensitivity aquagel (Az-CH-LA): lactose cross-linked chitosan (CH-LA), 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), 4-azidobenzoic acid, N, N, N ', N '-tetramethylethylenediamine (TEMED) reacts, filter, concentrate, obtain heliosensitivity aquagel.
Wherein, in step (1), chitosan, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-O-β-D-galactose-(1,4) mass ratio of-maltonic acid is 500:130:1, N, N, N ', the concentration of N '-tetramethylethylenediamine (TEMED) aqueous solution is 50mM; Reaction temperature is room temperature, and the response time is 24h.
Wherein, in step (2), the mass ratio of lactose cross-linked chitosan (CH-LA), 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), 4-azidobenzoic acid is 20:7:4, N, N, N ', N ' concentration of-tetramethylethylenediamine (TEMED) aqueous solution is 50mM; Reaction temperature is room temperature, and the response time is 72h.
This vascular occluding device in use, embolism intervention catheter is utilized to be injected in tumor vessel by the heliosensitivity aquagel suppository of dissolved colloidal state, under the irradiation of the ultraviolet light of the light emitting diode in embolism intervention catheter end, the heliosensitivity aquagel suppository generation gelation of dissolved colloidal state, be transformed into elastic gel that is insoluble, that do not melt, have cross-linked structure, thus realize the effect of the vascular embolization of tumor specific part.Because the heliosensitivity aquagel suppository of dissolved colloidal state can be full of whole blood vessel, after therefore changing gel into, blood supply can be blocked more completely; Heliosensitivity aquagel has the general property of macromolecule polymer material simultaneously, makes this thromboembolism have good intensity and long stability.
Beneficial effect: embolism intervention catheter provided by the invention, structure is simple, with low cost, can change suppository into gel after being provided with light emitting diode irradiation heliosensitivity aquagel suppository wherein by end, thromboembolism is had, and integrity is high, intensity good, the feature of good stability.
Heliosensitivity aquagel preparation technology in embolism intervention catheter provided by the invention is simple, has liquid-solid biphase controlled property of transition, can increase suddenly at viscosity under irradiation under ultraviolet ray, be transformed into the insoluble elastic gel with cross-linked structure.
Accompanying drawing explanation
Fig. 1 is can the structural representation of luminous interposing catheter.
Fig. 2 is can the profile of luminous interposing catheter.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only for illustration of the present invention, and should can not limit the present invention described in detail in claims yet.
Embodiment 1
Heliosensitivity aquagel, is polymerized by chitosan, lactic acid and 4-azidobenzoic acid.
Its preparation method, comprises the following steps:
(1) synthesis of lactose cross-linked chitosan (CH-LA)
1,125g chitosan is joined the N of the 50mM of 3L, N, N ', in N '-tetramethylethylenediamine (TEMED) aqueous solution, the pH value also containing 56.25mL in this solution is the concentrated hydrochloric acid of 4.75.
2,32.5g1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 0.25g4-O-β-D-galactose-(Isosorbide-5-Nitrae)-maltonic acid is added again.
3, ultrafilter membrane is used to carry out concentrated purification after mixed solution being stirred 24 hours at normal temperatures.
4, lactose cross-linked chitosan molecule (CH-LA) is obtained by lyophilization.
(2) synthesis of heliosensitivity aquagel (Az-CH-LA)
1, by 1g lactose cross-linked chitosan (CH-LA), 0.35g1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), and 0.2g4-azidobenzoic acid joins the N of the 50mM of 100mL, N, N ', N ' in-tetramethylethylenediamine (TEMED) aqueous solution.
2, ultrafilter membrane is used to carry out concentrated purification after mixed solution being stirred 72 hours at normal temperatures.
3, heliosensitivity aquagel (Az-CH-LA) is obtained by lyophilization.
Embodiment 2
Vascular occluding device, is shown in Fig. 1 and Fig. 2, comprises embolism intervention catheter and suppository; Embolism intervention catheter comprises the interior pipe 2 of one group of light emitting diode 3 and the outer tube 1 from outer to inner set gradually and hollow; Light emitting diode 3 is located at embolism intervention catheter one end, and is connected with the wire 4 arranged between outer tube 1 and interior pipe 2; Pass into suppository in the interior pipe 2 of embolism intervention catheter, suppository is heliosensitivity aquagel.
Wherein, the external diameter of outer tube 1 is 3mm; The internal diameter of interior pipe 2 is 2mm; Alternatively, the diameter of outer tube 1 and interior pipe 2 also can choose reasonable as required, and preferably, the internal diameter of interior pipe 2 is 1-2.5mm; The internal diameter 1-1.5mm larger than the internal diameter of interior pipe 2 of described outer tube 1.
Utilize above-mentioned vascular occluding device to carry out Embolization procedures, step is as follows:
1, heliosensitivity aquagel suppository is joined and in luminous interposing catheter, conduit can be inserted into cancer target position;
2, utilize thromboembolism interventional method that heliosensitivity aquagel suppository is driven into tumor specific part, be energized to diode simultaneously, diode is made to send ultraviolet light, under the irradiation of the ultraviolet light of the light emitting diode in embolism intervention catheter end, the heliosensitivity aquagel suppository generation gelation of dissolved colloidal state, be transformed into elastic gel that is insoluble, that do not melt, have cross-linked structure, thus reach the object of occlusion of bone tumors blood vessel.
Claims (7)
1. an embolism intervention catheter, is characterized in that: described embolism intervention catheter comprises the interior pipe (2) of one group of light emitting diode (3) and the outer tube (1) from outer to inner set gradually and hollow; Light emitting diode (3) is located at embolism intervention catheter one end, and is connected with the wire (4) arranged between outer tube (1) and interior pipe (2).
2. a kind of embolism intervention catheter according to claim 1, is characterized in that: the internal diameter of described interior pipe (2) is 1-2.5mm; The internal diameter 1-1.5mm larger than the internal diameter of interior pipe (2) of described outer tube (1).
3. a vascular occluding device, is characterized in that: comprise the embolism intervention catheter described in claim 1 or 2, also comprise pass in embolism intervention catheter suppository, described suppository is heliosensitivity aquagel.
4. a kind of vascular occluding device according to claim 3, is characterized in that: the structural formula of described heliosensitivity aquagel is:
5. a kind of vascular occluding device according to claim 4, is characterized in that: the preparation method of described heliosensitivity aquagel comprises the following steps:
(1) synthesis of lactose cross-linked chitosan (CH-LA): chitosan, N, N, N ', N '-tetramethylethylenediamine (TEMED), 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-O-β-D-galactose-(1,4)-maltonic acid reacts in acid condition, filter, concentrate, obtain lactose cross-linked chitosan molecule (CH-LA);
(2) synthesis of heliosensitivity aquagel (Az-CH-LA): lactose cross-linked chitosan (CH-LA), 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), 4-azidobenzoic acid, N, N, N ', N '-tetramethylethylenediamine (TEMED) reacts, filter, concentrate, obtain heliosensitivity aquagel.
6. a kind of vascular occluding device according to claim 4, it is characterized in that: in step (1), chitosan, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-O-β-D-galactose-(1,4) mass ratio of-maltonic acid is 500:130:1, N, N, N ', the concentration of N '-tetramethylethylenediamine (TEMED) aqueous solution is 50mM; Reaction temperature is room temperature, and the response time is 24h.
7. a kind of vascular occluding device according to claim 4, it is characterized in that: in step (2), the mass ratio of lactose cross-linked chitosan (CH-LA), 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), 4-azidobenzoic acid is 20:7:4, N, N, N ', N ' concentration of-tetramethylethylenediamine (TEMED) aqueous solution is 50mM; Reaction temperature is room temperature, and the response time is 72h.
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| CN201310222100.4A CN103330583B (en) | 2013-06-05 | 2013-06-05 | Embolism intervention catheter and application thereof |
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| CN201310222100.4A CN103330583B (en) | 2013-06-05 | 2013-06-05 | Embolism intervention catheter and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9918718B2 (en) * | 2014-08-08 | 2018-03-20 | DePuy Synthes Products, Inc. | Embolic coil delivery system with retractable mechanical release mechanism |
| CN114209379A (en) * | 2021-12-13 | 2022-03-22 | 珠海通桥医疗科技有限公司 | Device for treating aneurysm |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308507A (en) * | 1998-07-06 | 2001-08-15 | 微温森公司 | Expansible implant for vascular embolization and method of making the same |
| CN100591291C (en) * | 2004-03-10 | 2010-02-24 | 皇家飞利浦电子股份有限公司 | Catheter, apparatus and method for therapeutic embolization |
| CN203290962U (en) * | 2013-06-05 | 2013-11-20 | 东南大学 | Embolization intervention catheter |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050133046A1 (en) * | 2003-12-17 | 2005-06-23 | Becker Timothy A. | Compositions and methods for improved occlusion of vascular defects |
| US20080167637A1 (en) * | 2006-10-13 | 2008-07-10 | Sonny Yamasaki | Method and apparatus for aneurismal treatment |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308507A (en) * | 1998-07-06 | 2001-08-15 | 微温森公司 | Expansible implant for vascular embolization and method of making the same |
| CN100591291C (en) * | 2004-03-10 | 2010-02-24 | 皇家飞利浦电子股份有限公司 | Catheter, apparatus and method for therapeutic embolization |
| CN203290962U (en) * | 2013-06-05 | 2013-11-20 | 东南大学 | Embolization intervention catheter |
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Inventor after: Sun Jianfei Inventor after: Qiu Shuang Inventor after: Ge Naijian Inventor after: Zhu Haidong Inventor after: Liu Xuan Inventor after: Zhang Jie Inventor after: Teng Gaojun Inventor after: Gu Ning Inventor before: Sun Jianfei Inventor before: Liu Xuan Inventor before: Ge Naijian Inventor before: Qiu Shuang Inventor before: Zhang Jie Inventor before: Gu Ning |
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Free format text: CORRECT: INVENTOR; FROM: SUN JIANFEI LIU XUAN GE NAIJIAN QIU SHUANG ZHANG JIE GU NING TO: SUN JIANFEI QIU SHUANG GE NAIJIAN ZHU HAIDONG LIU XUAN ZHANG JIE TENG GAOJUN GU NING |