CN103330583B - Embolism intervention catheter and application thereof - Google Patents

Embolism intervention catheter and application thereof Download PDF

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CN103330583B
CN103330583B CN201310222100.4A CN201310222100A CN103330583B CN 103330583 B CN103330583 B CN 103330583B CN 201310222100 A CN201310222100 A CN 201310222100A CN 103330583 B CN103330583 B CN 103330583B
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chitosan
interventional catheter
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CN103330583A (en
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孙剑飞
刘璇
葛乃建
邱爽
张捷
顾宁
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东南大学
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Abstract

本发明提供了一种栓塞介入导管,所述栓塞介入导管包括一组发光二极管(3)以及自外而内依次设置的外管(1)和中空的内管(2);发光二极管(3)设于栓塞介入导管一端,并与外管(1)和内管(2)之间设置的导线(4)连接。 The present invention provides an interventional catheter embolization, the embolic interventional catheter comprising a set of light emitting diodes (3) and the outer tube (1) and a hollow inner tube (2) arranged sequentially from outside to inside; a light emitting diode (3) an end plug disposed in the interventional catheter, and the outer tube (1) and the inner tube (2) disposed between the conductor (4) is connected. 本发明提供的栓塞介入导管,结构简单,成本低廉,通过端部设有发光二极管照射其中的光敏性壳聚糖水凝胶栓塞剂后可将栓塞剂从溶胶态转变为凝胶,使栓塞具有完整性高、强度好、稳定性佳的特点。 The present invention provides the interventional catheter embolization, simple structure, low cost, through the end provided with the light emitting diode is irradiated wherein the photosensitive chitosan hydrogel embolic agents embolic agent may transition from a sol state to a gel, so that a complete plug high performance, good strength, good stability characteristics.

Description

一种栓塞介入导管及其应用 Embolic obstruction interventional catheter and its application

技术领域 FIELD

[0001] 本发明属于生物医疗器械领域,特别涉及一种栓塞介入导管,还涉及该栓塞介入导管的应用。 [0001] The present invention belongs to the field of biomedical devices, particularly to an interventional catheter embolization, the embolic further relates to the use of the interventional catheter.

背景技术 Background technique

[0002] 癌症是一种严重危害人类生命健康的常见病,癌症发现晚、治愈难成为该病致死的重要原因。 Common [0002] Cancer is a serious harm to human life and health, cancer is detected late, difficult to cure the disease has become an important cause of death. 在我国,癌症已成为城市居民的头号死因和农村居民的第二大死亡原因。 In China, cancer has become the second largest cause of death in the number one cause of death of urban residents and rural residents. 大部分癌症病人发现时已属中晚期,已没有根治性手术治疗的机会。 Most cancer patients already advanced when discovered, had no chance of radical surgery. 常用的癌症非手术治疗方法包括:经导管血管栓塞术(Transcatheter Arterial Embolization,TAE)、放射治疗、 局部消融治疗及生物免疫治疗等。 Commonly used non-surgical treatment of cancer comprising: Transcatheter embolization (Transcatheter Arterial Embolization, TAE), radiation therapy, ablation therapy and immune therapy. 其中,TAE是目前癌症非手术治疗中使用最广、疗效最好的方法。 Which, TAE is a non-surgical treatment of cancer currently the most widely used, the best way to effect.

[0003] 介入导管是用于介入诊疗的一种医疗器械,尤其是较多地应用在经导管血管栓塞术介入诊疗方面。 [0003] interventional catheter for interventional treatment of a medical instrument, more particularly to applications in transcatheter embolization Intervention. 常用的介入导管可以把栓塞剂导入到特定部位,但不与栓塞剂发生相互作用,对栓塞剂的流动性、凝固时间等要求较高,栓塞效果不好,这就限制了栓塞剂的使用。 Conventional interventional catheter embolic agent can be introduced into a specific site, but does not interact with the embolic agent, the higher the fluidity of embolic agents, setting time, etc., not embolization effect, which limits the use of embolic agent.

[0004] 水凝胶是介于液体和固体之间的三维网络或互穿网络,是一种能显著地溶胀于水但在水中并不能溶解的亲水聚合物凝胶。 [0004] Hydrogels are three-dimensional network is interposed between a liquid and a solid or interpenetrating network, is a significantly swells in water but does not dissolve in water and a hydrophilic polymer gel. 智能型水凝胶则会对环境刺激有响应性,是近年来的研究热点。 Intelligent hydrogel will have a response to environmental stimuli, it is a hot topic in recent years. 光敏性壳聚糖水凝胶能在紫外光照射下黏度突然增加,转变成不溶、不熔、 具有交联网状结构的弹性凝胶,因此在经导管血管栓塞术中具有潜在应用。 Chitosan hydrogels photosensitive sudden increase in viscosity under UV irradiation, into an insoluble, infusible, having reticulate elastic gel structure, thus having potential application in the transcatheter embolization.

发明内容 SUMMARY

[0005] 发明目的:本发明的目的是提供一种栓塞介入导管。 [0005] Object of the invention: object of the present invention is to provide a plug interventional catheter.

[0006] 本发明的第二目的是提供上述栓塞介入导管的应用。 [0006] The second object of the present invention is the use of the interventional catheter to provide the above-described plug.

[0007] 技术方案:本发明提供的一种栓塞介入导管,所述栓塞介入导管包括一组发光二极管以及自外而内依次设置的外管和中空的内管;发光二极管设于栓塞介入导管一端,并与外管和内管之间设置的导线连接。 [0007] The technical solutions: A plug provided interventional catheter according to the present invention, the plug comprises a set of interventional catheter outer tube and the light emitting diode and a hollow inner tube disposed sequentially from outside to inside; a light emitting diode provided on an end of the interventional catheter embolization and connected with wires disposed between the outer tube and the inner tube.

[0008] 作为优选,所述内管的内径为1-2. 5mm ;所述外管的内径比内管的内径大1_L 5mm〇 [0008] Advantageously, the inner diameter of the inner tube is 1-2 5mm;. Internal diameter of the outer tube 1_L larger than the inner diameter of the inner tube 5mm〇

[0009] 本发明还提供了一种血管栓塞装置,包括上述的栓塞介入导管,还包括通入栓塞介入导管内的栓塞剂,所述栓塞剂为光敏性壳聚糖水凝胶。 [0009] The present invention also provides a vascular embolization device, comprising the above-described plug interventional catheter further comprising embolization into embolic agent within the catheter, the embolic agent is photosensitive chitosan hydrogel.

[0010] 作为优选,所述光敏性壳聚糖水凝胶的结构式为: [0010] Advantageously, the structural formula of the photosensitive chitosan hydrogel is:

[0011] [0011]

Figure CN103330583BD00051

[0012] 该光敏性壳聚糖水凝胶的生物相容性高,避免了异物对人体带来的副作用。 [0012] The high photosensitivity chitosan hydrogel biocompatibility, avoiding side effects on the human body caused by foreign bodies.

[0013] 作为进一步优选,所述光敏性壳聚糖水凝胶的制备方法包括以下步骤: [0013] As a further preferred method of preparing the photosensitive chitosan hydrogel comprising the steps of:

[0014] (1)乳糖交联壳聚糖(CH-LA)的合成:脱乙酰壳聚糖、N,N,N',N' -四甲基乙二胺(TEMED)、1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)和4-0-0-D-半乳糖-(1,4)-D-葡萄糖酸在酸性条件下反应,过滤、浓缩,得乳糖交联壳聚糖分子(CH-LA); (2)光敏性壳聚糖水凝胶(Az-CH-LA)的合成:乳糖交联壳聚糖(CH-LA)U-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)、4_叠氮苯甲酸、N,N,N',N' -四甲基乙二胺(TEMED) 反应,过滤、浓缩,即得光敏性壳聚糖水凝胶。 [0014] (1) Synthesis of lactose crosslinked chitosan (CH-LA): The chitosan, N, N, N ', N' - tetramethylethylenediamine (TEMED), 1- ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-0-0-D- galactose - (1,4) -D- gluconic acid under acidic conditions, filtered , and concentrated to give lactose crosslinked chitosan (CH-LA); (2) synthesis of photosensitive chitosan hydrogel (Az-CH-LA) of: lactose crosslinked chitosan (CH-LA) U- ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), 4_ acid azide, N, N, N ', N' - tetramethylethylenediamine (of TEMED) The reaction was filtered, concentrated to afford the photosensitive chitosan hydrogel.

[0015] 其中,步骤(1)中,脱乙酰壳聚糖、1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)和4-0-0-D-半乳糖-(1,4)-D-葡萄糖酸的质量比为500:130:1,N,N,N',N' -四甲基乙二胺(TEMED)水溶液的浓度为50mM ;反应温度为室温,反应时间为24h。 [0015] wherein, in step (1), a chitosan, 1-ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-0-0-D - galactose - (1,4) -D- gluconic acid mass ratio is 500: 130: 1, N, N, N ', N' - tetramethylethylenediamine concentration (of TEMED) solution of 5OmM; reaction temperature was room temperature, the reaction time was 24h.

[0016] 其中,步骤(2)中,乳糖交联壳聚糖(CH-LA)U-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)、4_叠氮苯甲酸的质量比为20:7:4, N,N,N',N' -四甲基乙二胺(TEMED) 水溶液的浓度为50mM ;反应温度为室温,反应时间为72h。 [0016] wherein, in step (2), the lactose crosslinked chitosan (CH-LA) U- ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), 4_ acid azide mass ratio of 20: 7: 4, N, N, N ', N' - tetramethylethylenediamine concentration (of TEMED) solution of 5OmM; the reaction temperature is room temperature, the reaction time was 72h.

[0017] 该血管栓塞装置在使用时,利用栓塞介入导管将溶胶态的光敏性壳聚糖水凝胶栓塞剂注射入肿瘤血管中,在栓塞介入导管端部的发光二极管的紫外光的照射下,溶胶态的光敏性壳聚糖水凝胶栓塞剂发生凝胶化,转变成不溶、不熔、具有交联网状结构的弹性凝胶,从而实现肿瘤特定部位的栓塞血管的作用。 [0017] The vascular embolization device is in use, using interventional catheter plug photosensitive chitosan hydrogel embolic agent in the sol state is injected into the tumor vessels, exposure to UV light emitting diode embolization interventional catheter end portion, gelled, converted into an insoluble, infusible, having reticulate elastic gel structure, in order to achieve site specific tumor vascular embolization effect of chitosan hydrogel embolic agents photosensitive sol state occurs. 由于溶胶态的光敏性壳聚糖水凝胶栓塞剂可充满整个血管,因此转变为凝胶后可较完全的堵塞供血;同时光敏性壳聚糖水凝胶具有高分子聚合物材料的一般属性,使得该栓塞具有较好的强度和长时间的稳定性。 Since the photosensitivity chitosan hydrogel embolic agent in the sol state can be filled with blood vessels, and therefore can be more completely converted to the blocked blood after gel; chitosan hydrogel having photosensitivity while general attributes of polymer material, such that the plug has a good strength and stability over time.

[0018] 有益效果:本发明提供的栓塞介入导管,结构简单,成本低廉,通过端部设有发光二极管照射其中的光敏性壳聚糖水凝胶栓塞剂后可将栓塞剂转变为凝胶,使栓塞具有完整性高、强度好、稳定性佳的特点。 [0018] Advantageous Effects: The present invention provides the interventional catheter embolization, simple structure, low cost, through the end provided with the light emitting diode is irradiated wherein the photosensitive chitosan hydrogel embolic agents may be embolic agent into the gel, so that plug having a high integrity, high strength, good stability characteristics.

[0019] 本发明提供的栓塞介入导管中的光敏性壳聚糖水凝胶制备工艺简单,具有液-固两相可控的转变性质,能够在紫外光照射下黏度突然增加,转变成不溶的具有交联网状结构的弹性凝胶。 [0019] The present invention provides photosensitive intervention embolic chitosan hydrogel catheter manufacturing process is simple, with a liquid - solid two-phase transition controllable properties, can be abrupt increase in viscosity under ultraviolet light, having converted to insoluble cross elastic gel reticulate structure.

附图说明 BRIEF DESCRIPTION

[0020] 图1为可发光介入导管的结构示意图。 [0020] FIG. 1 is a schematic structural diagram of the interventional catheter may emit light.

[0021] 图2为可发光介入导管的剖面图。 [0021] FIG sectional view of the interventional catheter 2 to be luminescent.

具体实施方式 Detailed ways

[0022] 根据下述实施例,可以更好地理解本发明。 [0022] The following examples, the present invention may be better understood. 然而,本领域的技术人员容易理解,实施例所描述的具体的物料配比、工艺条件及其结果仅用于说明本发明,而不应当也不会限制权利要求书中所详细描述的本发明。 However, those skilled in the art will readily appreciate the specific materials described embodiments ratio, the process conditions and the results are only illustrative of the invention and should not be limiting the claim is not described in detail in the book of the present invention .

[0023] 实施例1 [0023] Example 1

[0024] 光敏性壳聚糖水凝胶,由壳聚糖、乳酸和4-叠氮苯甲酸聚合而成。 [0024] The photosensitive chitosan hydrogel by polymerizing chitosan, lactic acid and benzoic acid 4-azido made.

[0025] 其制备方法,包括以下步骤: [0025] The preparation method, comprising the steps of:

[0026] (1)乳糖交联壳聚糖(CH-LA)的合成 [0026] (1) Lactose crosslinked chitosan (CH-LA) Synthesis of

[0027] 1、将125§脱乙酰壳聚糖加入到31的50禮的^^,^-四甲基乙二胺(了£1^)) 水溶液中,该溶液中还含有56. 25mL的pH值为4. 75的浓盐酸。 [0027] 1, the 125§ chitosan was added to 50 of 31 ^^ Li ^ - tetramethylethylenediamine (a £ ^ 1)) an aqueous solution, which solution also contains 56. 25mL of concentrated hydrochloric acid a pH of 4.75.

[0028] 2、再加入32. 5gl-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)和0• 25g4-0- P -D-半乳糖-(1,4) -D-葡萄糖酸。 [0028] 2, then add 32. 5gl- ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 0 • 25g4-0- P -D- galacto - (1 , 4) -D- gluconate.

[0029] 3、将混合后的溶液在常温下搅拌24小时后使用超滤膜进行浓缩提纯。 [0029] 3, the mixed solution was concentrated using an ultrafiltration membrane purification was stirred for 24 hours at room temperature.

[0030] 4、通过冻干法得到乳糖交联壳聚糖分子(CH-LA)。 [0030] 4, to give lactose crosslinked chitosan (CH-LA) by lyophilization.

[0031] (2)光敏性壳聚糖水凝胶(Az-CH-LA)的合成 [0031] (2) The photosensitive chitosan hydrogel (Az-CH-LA) Synthesis of

[0032] 1、将Ig乳糖交联壳聚糖(CH-LA)、0. 35gl-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC),以及0. 2g4-叠氮苯甲酸加入到IOOmL的50mM的N,N,N',N'-四甲基乙二胺(TEMED)水溶液中。 [0032] 1, the crosslinked chitosan Ig lactose (CH-LA), 0 35gl- ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (the EDC), and 0. 2g4- azido acid was added to 50mM IOOmL of the N, N, N ', N'- tetramethylethylenediamine (of TEMED) solution.

[0033] 2、将混合后的溶液在常温下搅拌72小时后使用超滤膜进行浓缩提纯。 [0033] 2, after the mixed solution was stirred at room temperature for 72 hours and concentrated using an ultrafiltration membrane purification.

[0034] 3、通过冻干法得到光敏性壳聚糖水凝胶(Az-CH-LA)。 [0034] 3, to obtain a photosensitive chitosan hydrogel (Az-CH-LA) by lyophilization.

[0035] 实施例2 [0035] Example 2

[0036] 血管栓塞装置,见图1和图2,包括栓塞介入导管和栓塞剂;栓塞介入导管包括一组发光二极管3以及自外而内依次设置的外管1和中空的内管2 ;发光二极管3设于栓塞介入导管一端,并与外管1和内管2之间设置的导线4连接;栓塞介入导管的内管2内通入栓塞剂,栓塞剂为光敏性壳聚糖水凝胶。 [0036] The embolization device shown in Figure 1 and 2, comprising a plug interventional catheter and embolic agent; embolization interventional catheter comprising a set of light emitting diodes 3 and the outer tube 1 and a hollow inner tube disposed sequentially from outside to inside 2; emission diode plug 3 provided in an end of the interventional catheter and connected with the wire 2 is provided between the outer tube 1 and inner tube 4; the inner tube 2 interventional catheter embolization embolic agent into the embolic agent for the photosensitive chitosan hydrogel.

[0037] 其中,外管1的外径为3mm ;内管2的内径为2mm ;可选地,外管1和内管2的直径也可以根据需要合理选择,优选地,内管2的内径为1-2. 5mm ;所述外管1的内径比内管2的内径大1-1. 5mm。 [0037] wherein the outer diameter of the outer tube 1 is 3mm; inner diameter of the inner tube 2 is 2mm; alternatively, the diameter of the inner tube 1 and outer tube 2 may be reasonably selected as desired, preferably, the inner diameter of the inner tube 2 is 1-2 5mm;. a large inner diameter than the inner diameter of 1-12 in the outer tube 1. 5mm..

[0038] 利用上述血管栓塞装置进行栓塞操作,步骤如下: [0038] The operation performed using the endovascular embolization device, the following steps:

[0039] 1、将光敏性壳聚糖水凝胶栓塞剂加入到可发光介入导管中,将导管插入到肿瘤靶向部位; [0039] 1, the photosensitive chitosan hydrogel embolic agents may be added to the light emitting interventional catheter, a catheter is inserted into a tumor targeting site;

[0040] 2、利用栓塞介入方法将光敏性壳聚糖水凝胶栓塞剂打入到肿瘤特定部位,同时给二极管通电,使二极管发出紫外光,在栓塞介入导管端部的发光二极管的紫外光的照射下, 溶胶态的光敏性壳聚糖水凝胶栓塞剂发生凝胶化,转变成不溶、不熔、具有交联网状结构的弹性凝胶,从而达到栓塞肿瘤血管的目的。 [0040] 2, using the plug interventional photosensitive chitosan hydrogel embolic agent into a particular tumor site while the diode to energize the diode emits ultraviolet light, the ultraviolet light emitting diode intervention plug end portion of the catheter under irradiation, the photosensitive chitosan hydrogel embolic agents gelation in the sol state, into an insoluble, infusible, reticulate structure having elastic gel, so as to achieve the purpose of tumor embolization of blood vessels.

Claims (7)

1. 一种栓塞介入导管,其特征在于:所述栓塞介入导管包括一组发光二极管(3)以及自外而内依次设置的外管(1)和中空的内管(2);发光二极管(3)设于栓塞介入导管一端, 并与外管(1)和内管(2)之间设置的导线(4)连接。 An interventional catheter embolism, wherein: the plug interventional catheter comprising a set of light emitting diodes (3) and the outer tube (1) and a hollow inner tube (2) arranged sequentially from outside to inside; a light emitting diode ( 3) provided at one end of the interventional catheter plug, and the outer tube (1) and the inner tube (2) disposed between the conductor (4) is connected.
2. 根据权利要求1所述的一种栓塞介入导管,其特征在于:所述内管(2)的内径为1-2. 5mm;所述外管(1)的内径比内管(2)的内径大I-L5mm。 2. A plug according to one of the interventional catheter according to claim 1, characterized in that: the inner diameter of the tube (2) is within the 1-2 5mm; inner diameter of the outer tube (1) than the inner tube (2). the inner diameter of the large I-L5mm.
3. -种血管栓塞装置,其特征在于:包括权利要求1或2所述的栓塞介入导管,还包括通入栓塞介入导管内的的栓塞剂,所述栓塞剂为光敏性壳聚糖水凝胶。 3 - Species embolization device, comprising: a plug of claim 1 or claim 2, wherein the interventional catheter further comprising embolization embolic agent into the inner conduit, the photosensitive embolic agent is a chitosan hydrogel .
4. 根据权利要求3所述的一种血管栓塞装置,其特征在于:所述光敏性壳聚糖水凝胶的结构式为: * According to an intravascular embolization device according to claim 3, wherein: said photosensitive chitosan hydrogel of the formula: *
Figure CN103330583BC00021
5. 根据权利要求4所述的一种血管栓塞装置,其特征在于:所述光敏性壳聚糖水凝胶的制备方法包括以下步骤: (1) 乳糖交联壳聚糖(CH-LA)的合成:脱乙酰壳聚糖、N,N,N',N' -四甲基乙二胺(TEMED)、1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)和4-0-β-D-半乳糖_(1,4)-D-葡萄糖酸在酸性条件下反应,过滤、浓缩,得乳糖交联壳聚糖分子(CH-LA); (2) 光敏性壳聚糖水凝胶(Az-CH-LA)的合成:乳糖交联壳聚糖(CH-LA)、1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)、4-叠氮苯甲酸、Ν,Ν,Ν',Ν' -四甲基乙二胺(TEMED)反应,过滤、浓缩,即得光敏性壳聚糖水凝胶。 A vascular embolization device according to claim 4, characterized in that: said photosensitive preparing chitosan hydrogel comprising the steps of: (1) Lactose crosslinked chitosan (CH-LA) of synthesis: chitosan, N, N, N ', N' - tetramethylethylenediamine (TEMED), 1- ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-0-β-D- galactose _ (1,4) -D- gluconic acid under acidic conditions of the reaction, filtered, and concentrated to give lactose crosslinked chitosan (CH-LA); ( 2) synthesis of photosensitive chitosan hydrogel (Az-CH-LA) of: lactose crosslinked chitosan (CH-LA), 1- ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), 4- azido acid, Ν, Ν, Ν ', Ν' - tetramethylethylenediamine (of TEMED) the reaction, filtered and concentrated to afford the photosensitive chitosan hydrogel.
6. 根据权利要求4所述的一种血管栓塞装置,其特征在于:步骤(1)中,脱乙酰壳聚糖、1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)和4-0-β-D-半乳糖-(1,4)-D-葡萄糖酸的质量比为500:130:1,Ν,Ν,Ν',Ν' -四甲基乙二胺(TEMED)水溶液的浓度为50mM;反应温度为室温,反应时间为24h。 A vascular embolization device according to claim 4, wherein: step (1), chitosan, 1-ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-0-β-D- galactose - (1,4) -D- gluconic acid mass ratio is 500: 130: 1, Ν, Ν, Ν ', Ν' - tetramethylxylylene the concentration of ethylene diamine (of TEMED) solution of 5OmM; the reaction temperature is room temperature, the reaction time was 24h.
7.根据权利要求4所述的一种血管栓塞装置,其特征在于:步骤(2)中,乳糖交联壳聚糖(CH-LA)、1_乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)、4_叠氮苯甲酸的质量比为20:7:4,Ν,Ν,Ν',Ν' -四甲基乙二胺(TEMED)水溶液的浓度为50mM;反应温度为室温, 反应时间为72h。 An intravascular embolization device according to claim 4, wherein: the step (2), the lactose crosslinked chitosan (CH-LA), 1_ ethyl - (3-dimethylaminopropyl yl) carbodiimide hydrochloride (EDC), benzoic acid azide 4_ mass ratio of 20: 7: 4, Ν, Ν, Ν ', Ν' - tetramethylethylenediamine (of TEMED) solution of concentration of 5OmM; The reaction temperature is room temperature, the reaction time was 72h.
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CN203290962U (en) * 2013-06-05 2013-11-20 东南大学 Embolization intervention catheter

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CN1308507A (en) * 1998-07-06 2001-08-15 微温森公司 Expansible implant for vascular embolization and method of making the same
CN100591291C (en) * 2004-03-10 2010-02-24 皇家飞利浦电子股份有限公司 Catheter, apparatus and method for therapeutic embolization
CN203290962U (en) * 2013-06-05 2013-11-20 东南大学 Embolization intervention catheter

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