CN103315703B - A kind of opthalmic optics's test model for fundus imaging - Google Patents

A kind of opthalmic optics's test model for fundus imaging Download PDF

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CN103315703B
CN103315703B CN201310211334.9A CN201310211334A CN103315703B CN 103315703 B CN103315703 B CN 103315703B CN 201310211334 A CN201310211334 A CN 201310211334A CN 103315703 B CN103315703 B CN 103315703B
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test
test target
lens
external member
fundus
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CN103315703A (en
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任秋实
江晓芸
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Peking University
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Peking University
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Abstract

The invention discloses a kind of opthalmic optics's test model for fundus imaging.Opthalmic optics's test model of the present invention comprises: corneal lens external member, pupil, lens external member, transparency liquid, optical fundus test target and tubular shell; Further, test target in optical fundus is divided into two kinds: resolution test target and hierarchy test target.Model of the present invention possesses the optical texture of human eye, meets the dioptric parameter of human eye, and is equipped with two kinds of test targets in position, optical fundus, for the imaging device of the monolayers such as fundus camera, adopts resolution test target, can the accessible ultimate resolution of detection system.For the imaging device to the imaging of retina the deep information such as optical fundus confocal scanning imager and optical fundus optical coherent chromatographic imaging instrument, adopt hierarchy test target, its longitudinal cutting structure can be presented, thus detecting and assessing imaging device longitudinal resolution in the tissue and lateral resolution.

Description

A kind of opthalmic optics's test model for fundus imaging
Technical field
The present invention relates to opthalmic optics's test model, particularly relate to a kind of opthalmic optics's test model for fundus imaging.
Background technology
The model of the simulation human eye existed in the market is divided into two classes substantially: a class is the anatomical model of eyeball, lively in detail illustrates the form comprising cornea, iris, crystalline lens, optical fundus etc., be mainly used in biology or medical teaching use, understand the physiological structure of eyes for student, do not possess optical property; Another kind of human-eye model, there is certain optical parametric, be mainly used in teaching, make student understand the image-forming principle of eyes, or practise using ophthalmoscope etc. directly to observe the instrument and equipment of eyes for ophthalmology intern, the longitudinal cutting structure of eye ground can not be observed with optical detecting method, and do not possess quantitative function.
For optical fundus optical coherent chromatographic imaging instrument OCT and optical fundus confocal scanning imager CSLO etc. to fundus imaging to detect the fundus imaging equipment on optical fundus, domestic at present do not have standard test models unified in industry, for evaluating the imaging performance parameter of these equipment.
Summary of the invention
For solving existing model Problems existing, the invention provides a kind of opthalmic optics's test model, this model possesses the optical texture of human eye, meet the dioptric parameter of human eye, and two kinds of test targets are equipped with in position, optical fundus, can human eye be replaced, accurately detect the imaging performance parameter of imaging device.
The object of the present invention is to provide a kind of opthalmic optics's test model for fundus imaging.
Opthalmic optics's test model for fundus imaging of the present invention comprises: corneal lens external member, pupil, lens external member, transparency liquid, optical fundus test target and tubular shell; Wherein, test target in optical fundus is arranged on the bottom of tubular shell; Corneal lens external member arranges the top of tubular shell and is sealed; Pupil is positioned at the inner surface of corneal lens external member; Lens external member be arranged on pupil inner surface and with optical fundus test target spacing be an image-forming range; Transparency liquid is full of in tubular shell; The effective focal length of the lens that image-forming range is lens external member, corneal lens external member and transparency liquid are formed jointly; Further, test target in optical fundus is divided into two kinds: resolution test target and hierarchy test target.
Corneal lens external member is equivalent to the cornea of human eye, and comprise corneal lens and corneal lens bracket further, corneal lens is positioned at the central authorities of corneal lens bracket.
Pupil is equivalent to the pupil of human eye, and the center of pupil is provided with through hole, and remainder is lighttight, thus light enters model by through hole.The diameter of through hole is between 3 ~ 8mm.The material of pupil adopts lighttight material, or comprises lighttight material at its outer surface.
Lens external member is equivalent to the crystalline lens of human eye, comprises crystalline lens bracket and lens further, and lens is positioned at the central authorities of crystalline lens bracket.
Transparency liquid is the material with the refractive index close of aqueous humor, as pure water, normal saline or artificial vitreous etc.
Except the through hole of pupil, other parts of opthalmic optics's test model are lighttight.Pupil and cylindrical case can be adopted to be lighttight material, or other parts except through hole are wrapped up with lighttight material.
Optical fundus test target is equivalent to the retina of human eye, adopts resolution test target or hierarchy test target.Resolution test target is provided with test chart at the bottom of opaque target, and test chart adopts the optical resolution test chart of standard, as 1951USAF (just), NBS1963A (just).For the imaging device of the monolayers such as fundus camera, adopt resolution test target, by imaging device, imaging is carried out to model, can the accessible ultimate resolution of detection system.Hierarchy test target material adopts macromolecular material, as silicone elastomer (silicone elastomer) and acrylic PMMA etc.; Comprise the uniform multilamellar of thickness, the thickness of every one deck is between 30 ~ 120 μm.Every one deck in hierarchy test target has different refractive indexs, and its absorptance and scattering coefficient are close to amphiblestroid optical parametric.In hierarchy test target, be mixed with the nanoparticle of known dimensions, be equivalent to the not homogeneous texture as blood vessel etc. in retina; The material of nanoparticle can be TiO 2, SiO 2, or golden nanometer particle; The size of nanoparticle is between 200 ~ 500nm.For the imaging device to the imaging of retina the deep information such as optical fundus confocal scanning imager and optical fundus optical coherent chromatographic imaging instrument, adopt hierarchy test target, imaging device carries out imaging to model, its longitudinal cutting structure can be presented, thus detecting and assessing imaging device longitudinal resolution in the tissue and lateral resolution.
Opthalmic optics's test model of the present invention, can replace human eye, is used for detecting the imaging performance parameter of fundus imaging equipment, imaging device to model imaging, by judging that the readability of imaging is to detect the imaging performance parameter of these imaging devices.
Advantage of the present invention:
The invention provides a kind of opthalmic optics's test model, this model possesses the optical texture of human eye, meet the dioptric parameter of human eye, and two kinds of optical fundus test targets are equipped with in position, optical fundus, resolution test target and hierarchy test target, be respectively used to its longitudinal resolution in the tissue of the accessible ultimate resolution of detection system and detecting and assessing and lateral resolution.
Accompanying drawing explanation
Fig. 1 is the structural representation of Gullstrand-Le Grand schematic eye;
Fig. 2 is the profile of the opthalmic optics's test model for fundus imaging of the present invention;
Fig. 3 is the structural representation of the resolution test target of an embodiment of the opthalmic optics's test model for fundus imaging of the present invention, and wherein (a) is the front view of resolution test target, the enlarged drawing that (b) is test chart;
Fig. 4 is the profile of the hierarchy test target of an embodiment of the opthalmic optics's test model for fundus imaging of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, by embodiment, the present invention will be further described.
Fig. 1 is the structural representation of Gullstrand-Le Grand schematic eye, and as shown in Figure 1, human eye comprises cornea 01, aqueous humor 031, pupil, crystalline lens 02, vitreous body 032 and retina 04, and each structure parameter of this schematic eye is as following table:
As shown in Figure 2, according to the schematic eye of above-mentioned human eye, opthalmic optics's test model of the present embodiment comprises: corneal lens external member 1, pupil 2, lens external member 3, transparency liquid, optical fundus test target 4 and tubular shell 5; Wherein, test target 4 in optical fundus is arranged on the bottom of tubular shell 5; Corneal lens external member 1 arranges the top of tubular shell 5 and is sealed; Pupil 2 is positioned at the inner surface of corneal lens external member 1; Lens external member 3 be arranged on pupil 2 inner surface and with optical fundus test target 4 spacing be an image-forming range.Further, corneal lens external member 1 comprises corneal lens 11 and corneal lens bracket 12, and corneal lens 11 is fixed on the central authorities of corneal lens bracket 12 by pressure ring 13, is sealed between corneal lens external member 1 and tubular shell by sealing ring 14.The center of pupil 2 is provided with through hole, and remainder is lighttight, and for the imaging device needing mydriasis, the diameter of pupil can reach 8mm, and for the imaging device of exempting from mydriasis, the diameter of pupil is 3 ~ 4mm.Lens external member 3 comprises crystalline lens bracket 32 and lens 31, and lens 31 is fixed on the central authorities of crystalline lens bracket 32 by pressure ring 33.
In the present embodiment, design parameter is: lens all adopt MgF 2the planoconvex lens of plated film, wherein corneal lens 11 diameter 12.0mm, focal length 24.0mm; Lens 31 diameter 15.0mm, focal length 22.5mm; Transparency liquid adopts pure water.
As shown in Fig. 3 (a), resolution test target be at the bottom of opaque target on be provided with test chart, as shown in Fig. 3 (b), test chart adopts 1951USAF (just) the optical resolution test chart of standard.
As shown in Figure 4, hierarchy test target comprise thickness all and four layers, the thickness of every one deck is 50 ~ 60 μm, and gross thickness is at 200 ~ 240 μm, and this is amphiblestroid approximate thickness.Material adopts silicone elastomer (silicone elastomer).Every one deck in hierarchy test target has different refractive indexs, and test as required and join, the scope of refractive index is between 1.41 ~ 1.49, and its absorptance and scattering coefficient are close to amphiblestroid optical parametric.The nanoparticle of known dimensions is mixed with, between the size 200 ~ 500nm of nanoparticle in hierarchy test target.
Resolution test target and hierarchy test target, be respectively used to its longitudinal resolution in the tissue of the accessible ultimate resolution of detection system and detecting and assessing and lateral resolution, resolution reaches micron dimension.
It is finally noted that, the object publicizing and implementing mode is to help to understand the present invention further, but it will be appreciated by those skilled in the art that: without departing from the spirit and scope of the invention and the appended claims, various substitutions and modifications are all possible.Therefore, the present invention should not be limited to the content disclosed in embodiment, and the scope that the scope of protection of present invention defines with claims is as the criterion.

Claims (6)

1. opthalmic optics's test model, for evaluating the imaging performance parameter of fundus imaging equipment, it is characterized in that, described opthalmic optics's test model comprises: corneal lens external member (1), pupil (2), lens external member (3), transparency liquid, optical fundus test target (4) and tubular shell (5); Wherein, described optical fundus test target (4) is arranged on the bottom of tubular shell (5); Described corneal lens external member (1) is arranged on the top of tubular shell (5) and is sealed; Described pupil (2) is positioned at the inner surface of corneal lens external member (1); Described lens external member (3) be arranged on pupil (2) inner surface and with optical fundus test target (4) spacing be an image-forming range; Transparency liquid is full of in described tubular shell (5); The effective focal length of the lens that described image-forming range is lens external member (3), corneal lens external member (1) and transparency liquid are formed jointly; Further, described optical fundus test target (4) is divided into two kinds: resolution test target and hierarchy test target; Described corneal lens external member (1) comprises corneal lens (11) and corneal lens bracket (12) further, and described corneal lens (11) is positioned at the central authorities of corneal lens bracket (12); Described lens external member (3) comprises crystalline lens bracket (32) and lens (31) further, and described lens (31) is positioned at the central authorities of crystalline lens bracket (32); Described transparency liquid is the material with the refractive index close of aqueous humor; Resolution test target is provided with test chart at the bottom of opaque target, and test chart adopts the optical resolution test chart of standard.
2. opthalmic optics's test model as claimed in claim 1, it is characterized in that, the center of described pupil (2) is provided with through hole, and remainder is lighttight, and the diameter of through hole is between 3 ~ 8mm.
3. opthalmic optics's test model as claimed in claim 1, it is characterized in that, except the through hole of pupil (2), other parts of described opthalmic optics's test model are lighttight, the material of pupil (2) and cylindrical case is lighttight material, or other parts except through hole is wrapped up with lighttight material.
4. opthalmic optics's test model as claimed in claim 1, is characterized in that, the material of described hierarchy test target adopts macromolecular material; Comprise the uniform multilamellar of thickness, the thickness of every one deck is between 30 ~ 120 μm.
5. opthalmic optics's test model as claimed in claim 4, is characterized in that, the every one deck in described hierarchy test target has different refractive indexs, and its absorptance and scattering coefficient are close to amphiblestroid optical parametric.
6. opthalmic optics's test model as claimed in claim 1, is characterized in that, be mixed with the nanoparticle of known dimensions in described hierarchy test target, the material of nanoparticle is TiO 2, SiO 2, one or more in gold nano grain; Size is between 200 ~ 500nm.
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CN103932682B (en) * 2014-05-07 2015-10-28 中国计量科学研究院 A kind of dimensional resolution plate for the evaluation of OCT equipment imaging performance and using method thereof
CN103932675B (en) * 2014-05-07 2016-04-13 中国计量科学研究院 A kind of test person eye model for ophthalmology OCT equipment three-dimensional imaging performance evaluation and using method thereof
CN106880340B (en) * 2017-03-09 2020-03-13 广州永士达医疗科技有限责任公司 OCT equipment imaging performance evaluation device and using method thereof
CN107478414B (en) * 2017-08-25 2023-09-22 广州永士达医疗科技有限责任公司 OCT imaging back-pumping performance testing device and method
CN107647845B (en) * 2017-10-30 2024-02-23 浙江省医疗器械检验院 Model eye for fundus detection and application method thereof
CN110680277B (en) * 2019-09-16 2021-08-27 中国计量科学研究院 Ophthalmic optical imaging and biological parameter measuring instrument calibration tool and use method thereof
CN110680276B (en) * 2019-09-16 2021-08-27 中国计量科学研究院 Ophthalmic optical imaging and biological parameter measuring instrument calibration tool and use method thereof
CN111238778A (en) * 2019-12-30 2020-06-05 重庆大学 Imaging performance detection system for active healthy ophthalmologic image products
CN112826439A (en) * 2020-12-31 2021-05-25 重庆贝奥新视野医疗设备有限公司 Ophthalmic optics coherence tomography instrument measuring device

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