CN1033140C - Machine made synthetic small blood vessel - Google Patents
Machine made synthetic small blood vessel Download PDFInfo
- Publication number
- CN1033140C CN1033140C CN90107744A CN90107744A CN1033140C CN 1033140 C CN1033140 C CN 1033140C CN 90107744 A CN90107744 A CN 90107744A CN 90107744 A CN90107744 A CN 90107744A CN 1033140 C CN1033140 C CN 1033140C
- Authority
- CN
- China
- Prior art keywords
- blood vessel
- small blood
- synthetic small
- unobstructed
- man
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention discloses an artificial small blood vessel which is weaved by a machine and has a diameter of 5mm to 0.6mm. A combined tissue structure of twisting yarns, flat veins or inclined veins is adopted by a vessel wall, and a heat treated shaping process is adopted in boiling water. The artificial small blood vessel can be optionally bent, and the vessel wall can not be shrunkened and dented. The edge of a fracture can not be decohered, and the seeping amount of blood is proper. An animal experiment and clinical application prove that the artificial small blood vessel can be applied to arteries and veins, and has a favorable effect. The artificial small blood vessel is an ideal substitute for the small blood vessel in a surgery operation.
Description
The invention belongs to medical artificial organ field, be specifically related to a kind of machine made synthetic small blood vessel.
According to the medical industries custom, little blood vessel is meant the blood vessel of diameter less than 1mm.The alleged synthetic small blood vessel of the present invention is meant the machine made synthetic small blood vessel between the diameter 5mm to 0.6mm.
When the human body normal blood vessels is suffered accidental injury, or when forming not recoverable infringement because of the obstruction of suffering from disease such as aneurysm and certain reason taking place, in order effectively to treat, at present domestic and international medical circle mostly adopts artificial blood vessel to substitute.Therefore, the research of artificial blood vessel, especially synthetic small blood vessel is significant in the surgery.Mention in " weaving polyester artificial vascular " literary composition, the primary structure of machine made synthetic small blood vessel is plain weave, twill or satin weave three major types.Shortcomings such as but the little blood vessel of these structures exists the oozing of blood amount big in clinical practice, and easily decoherence in the fracture edge and the blood flow patency rate is undesirable, the following little blood vessel of diameter 1mm is all the more so.For example, diameter is the synthetic small blood vessel patency rate only 75% of 0.8mm, and the synthetic small blood vessel of diameter below φ 0.6mm do not appear in the newspapers so far.
The present invention seeks to change the structural pipe wall of synthetic small blood vessel and improve its manufacture method, do not decoherenced in synthetic small blood vessel fracture edge, blood vessel wall oozing of blood amount is little, and compliance is good and higher blood flow patency rate arranged.
The technical scheme that realizes above-mentioned purpose is to adopt reeled yarn to add the comprehensive structural pipe wall that plain weave or reeled yarn add twill.Promptly the difference according to blood vessel diameter is pressed from both sides with different plain weaves or twill structure between the reeled yarn of two bursts of twistings.The warp number of folded plain weave or twill is between 1~3 between two strands of reeled yarns that the present invention adopts.
The method of typing is to insert the pole of the diameter match in pipe, behind the boiling water heat treatment, and cooling, drying again.
Advantage of the present invention is not decoherence at the incision position of the optional position of synthetic small blood vessel, and blood vessel wall oozing of blood amount is 40~82.5ml/cmminmmHG, inner wall smooth, have the fluffy structure of micropore, blood flow is unobstructed, and compliance is good, can twist arbitrarily, and not flat, do not subside; Sterilization treatment and stitching before easy to use.
The present invention has following accompanying drawing:
The little vascular tissue of Fig. 1 φ 0.6mm structural representation,
The little vascular tissue of Fig. 2 φ 2mm structural representation,
The little vascular tissue of Fig. 3 φ 4mm structural representation.
Embodiment:
Little blood vessel of the present invention is meant that diameter is the synthetic small blood vessel of φ 0.6~5mm.The material selection of little blood vessel helps cell tissue growth, to human body have no side effect 72
DThe pure terylene of danier (denier) is as warp, and 42
DThe pure terylene of danier (denier) is as parallel.Material also can be selected medical ptfe or polyurethane silk material for use.The organizational structure of little blood vessel is divided into basic organizational structure and aid in tissue structure, and basic organizational structure is a reeled yarn, and the aid in tissue structure is twill or plain weave structure.The reeled yarn structure has solved the problem of decoherencing, and supplementary structure has then played the inhibition oozing of blood, strengthens the effects such as body bone of blood vessel.Difference according to external caliber between the reeled yarn 1 of two bursts of twistings is pressed from both sides with different plain weave 2 or twill 3 structures.The scheme of the present invention design is: folded plain weave 2 or twill 3 warp numbers are between 1~3 between two strands of reeled yarns 1.Shown in Figure 1 is that diameter is the organizational structure sketch map of the little blood vessel of 0.6mm, and folded plain weave 2 warp numbers are 2 between two strands of reeled yarns 1.Shown in Figure 2 is that diameter is the organizational structure sketch map of the little blood vessel of 2mm, and folded twill 3 radial line numbers are 3 between two strands of reeled yarns 1.Shown in Figure 3 is that diameter is the organizational structure sketch map of the little blood vessel of 4mm, and folded twill 3 warp numbers are 3 between two strands of reeled yarns 1.
The manufacture method of machine made synthetic small blood vessel, generally comprise pipe weave, pure white, make stricture of vagina typing and all operations of sterilizing.In the existing manufacturing process, the method for making stricture of vagina typing is that artificial blood vessel is placed in the thermal finalization processing of making stricture of vagina and 270 on the corresponding model of size.The present invention will make the method for stricture of vagina typing and do improvement, weave and through inserting the metal bar or the non-metallic rods of the diameter that matches in the pipe of pure white processing heat treatment more than 10 minutes in boiling water, cooling then, drying.After handling like this, can make the synthetic small blood vessel inner wall smooth, the raw material ultimate fibre is fluffy, is beneficial to the growth of the unobstructed and cell tissue of blood flow.
The zoopery result of the artificial little blood vessel of the present invention is as follows.
Zoopery 1:
Synthetic small blood vessel with the diameter 0.6mm that sterilizes is sewn in rat femoral artery lower end.Excision femoral artery 15mm sews up with the long φ 0.6mm of 15mm synthetic small blood vessel, and the not damaged nylon wire of use 0/11 is made interrupted suture, stitches six pins altogether.Unclamp vascular clamp then, seeing that vessel outer wall is little has an oozing of blood.Pressed 3~5 minutes with saline gauze is light, remove saline gauze, oozing of blood stops fully.
Zoopery 2:
With diameter is that 3~4mm, length are the sterilization synthetic small blood vessel of 30~50mm, transplant artery and vein on the common carotid artery of pig and mesentery, make interrupted suture with 0/5 not damaged polypropylene synthetic fibers, every end seam 12~14 pins, use gauze pressing, behind the loose ends vascular clamp oozing of blood is arranged, but amount is few, i.e. hemostasis fully after about 5~10 minutes.
Art is opened otch one day after, and separate tissue is easy, and not seeing has adhesion, and the synthetic small blood vessel outer surface is clear, and incision position is not decoherenced.Postoperative was opened otch in five days, and tissue has adhesion, and the synthetic small blood vessel outer surface has the fibrous tissue calmness, but adhesion is insecure, easily peels off, and can peel off clean.Postoperative was opened otch in 15 days, and the tissue adhesion is more firm, and the synthetic small blood vessel outer surface has the thicker connective tissue of one deck to cover, and was stringer and arranged, be with peeling off than great strength, can not peel off thoroughly 1~5 day but do not resemble postoperative.Postoperative was opened otch in 30 days, and the tissue adhesion is more firm, and it is difficult to peel off, and adventitial tissue is thicker, and has neonatal blood vessels to nourish.
In addition, make tremulous pulse lower end replacement with 67 rabbit, the synthetic small blood vessel internal diameter is 0.6~0.8mm, unclamps vascular clamp after the stitching, and seeing has oozing of blood, but amount is few.With the light repoussage section of warm saline gauze synthetic small blood vessel after 3~5 minutes oozing of blood promptly end.Postoperative proves that through Doppler test and angiography the synthetic small blood vessel of transplanting is unimpeded fully until more than 3 months, and patency rate reaches 100%.
The clinical practice result of the artificial little blood vessel of the present invention is as follows.With the diameter of sterilization is that 1.6~2.2mm, length are that the synthetic small blood vessel of 180~240mm is transplanted in artery and vein behind the human body shin (from the internal malleolus more than the 50mm), and row reproduces artery and vein art behind the shin.Carry out interrupted suture with 0/9 not damaged polypropylene synthetic fibers, stitch 10 pins altogether, external bulk saline gauze covers, after unclamping the both sides vascular clamp oozing of blood is arranged, after 5~10 minutes, loosen binder with the binder pressure dressing, remove gauze, synthetic small blood vessel stops oozing of blood fully, press...withes one's finger to touch synthetic small blood vessel, and finger tip has the arterial pulse innervation.If reproduce posterior tibial veins then after sewing up 1~5 hour with 2 milliliters of syringes, syringe needle is inserted synthetic small blood vessel, all can extract venous blood out, show that blood flow is unobstructed.Now 34 routine patients' therapeutic outcome is listed in table 1.
With the sterilization 63 synthetic small blood vessels (internal diameter is that 0.6~4mm) tremulous pulse or the vein that is applied to 43 routine human bodies all obtained comparatively ideal effect, and the blood flow patency rate is 100%.Patient's postoperative can normally be participated in housework or physical work.
The artificial little blood vessel of the present invention operating position in the operation of flap burns unit is as follows:
Medical record number 230122, man, 22 years old, workman, two forearm hot crush injurys.The inboard flap free transplanting operation of capable right leg on August 11st, 1987, flap area 10 * 16cm
2The synthetic small blood vessel bridge joint.Tremulous pulse and two accompanying veins are scratched in the near-end right side, posterior tibial artery and two accompanying veins of the inboard free skin flap of far-end right leg.Synthetic small blood vessel: 1 φ 2.2 * 30 of tremulous pulse; 2 φ 2.2 * 30 of vein; Postoperative so far, artery and vein is all unimpeded.All the other cases differ and one enumerate.
Table 1 synthetic small blood vessel reproduces artery and vein patient chart behind the shin
Admission number | Sex | Age | Diagnosis | Artificial blood vessel internal diameter, length | Remarks |
213602 | The man | 28 | Right instep nitric acid is burnt | L.A.2.0mm×180mm | Unobstructed (3 years) |
215682 | The woman | 33 | Right ankle molten iron scald | L.A.2.0mm×220mm | Unobstructed (3 years) |
216042 | The woman | 22 | Left side ankle aluminum scald | R.A.1.8mm×180mm | Unobstructed (3 years) |
216593 | The man | 33 | Right ankle copper scald | L.A.2.2mm×170mm | Unobstructed (3 years) |
216593 | The man | 33 | Right ankle copper scald | L.V.2.4mm×170mm | Unobstructed (3 years) |
217654 | The man | 58 | Right instep copper scald | L.A.2.0mm×220mm | Unobstructed (3 years) |
217895 | The woman | 33 | The left finesse hot crush injury | R.A.2.0mm×300mm | Unobstructed (3 years) |
218046 | The woman | 34 | Right wrist hot crush injury | L.A.2.0mm×180mm | Unobstructed (3 years) |
219650 | The man | 17 | Instep, left side Colophonium is burnt | L.A.1.4mm×180mm | Unobstructed (3 years) |
219650 | The man | 17 | Instep, left side Colophonium is burnt | L.V.2.0mm×180mm | Unobstructed (3 years) |
222887 | The man | 22 | The left hand avulsion | R.A.2.0mm×210mm | Unobstructed (3 years) |
230140 | The man | 60 | Biped nitric acid is burnt | R.A.2.2mm×210mm | Unobstructed (3 years) |
230122 | The man | 22 | Two forearm hot crush injurys | R.A.2.2mm×150mm | Unobstructed (3 years) |
230122 | The man | 22 | Two forearm hot crush injurys | L.A.2.2mm×110mm | Unobstructed (3 years) |
230122 | The man | 22 | Two forearm hot crush injurys | R.V.2.4mm×150mm | Unobstructed (3 years) |
230122 | The man | 22 | Two forearm hot crush injurys | L.V.2.4mm×110mm | Unobstructed (3 years) |
239051 | The man | 20 | Right sufficient β burn | L.A.1.8mm×140mm | Unobstructed (1 year) |
252614 | The man | 62 | Right hand electric burn | L.A.2.2mm×80mm | Unobstructed (1 year) |
252614 | The man | 62 | Right hand electric burn | L.V.2.2mm×80mm | Unobstructed (2 1 year) |
252991 | The man | 62 | Left leg ankle scale cancer | R.A.1.6mm×120mm | Unobstructed (1 year) |
252991 | The man | 62 | Left leg ankle scale cancer | R.V.2.4mm×120mm | Unobstructed (2 1 year) |
257644 | The woman | 42 | The sufficient nitric acid in a left side is burnt | R.A.2.0mm×140mm | Unobstructed (1 year) |
257644 | The woman | 42 | The sufficient nitric acid in a left side is burnt | R.V.2.4mm×140mm | Unobstructed (half a year) |
259354 | The man | 53 | The sufficient lead water in a left side is scalded | R.A.2.0mm×200mm | Unobstructed (half a year) |
259354 | The man | 53 | The sufficient lead water in a left side is scalded | R.V.2.4mm×200mm | Unobstructed (two) |
258857 | The man | 54 | Right ankle chronic ulcer | L.A.1.8mm×130mm | Unobstructed (half a year) |
258857 | The man | 54 | Right ankle chronic ulcer | L.V.2.4mm×130mm | Unobstructed (two) |
262684 | The man | 23 | Left side wrist hot crush injury | R.A.2.0mm×140mm | Unobstructed (March) |
262684 | The man | 23 | Left side wrist hot crush injury | L.V.2.4mm×140mm | Unobstructed (two) |
The Suzhou Second Academy | The woman | 42 | The left hand avulsion | R.A.2.2mm×165mm | Unobstructed (1 year) |
The Suzhou Second Academy | The woman | 42 | The left hand avulsion | L.V.2.4mm×170mm | Unobstructed (1 year) |
The Suzhou Second Academy | The man | 40 | Right ankle avulsion | L.A.2.0mm×110mm | Unobstructed (1 year) |
The Suzhou Second Academy | The man | 40 | Right ankle avulsion | L.V.2.2mm×110mm | Unobstructed (1 year) |
The Suzhou Second Academy | The man | 31 | Right hand back of the body hot crush injury | L.A.2.0mm×110mm | Unobstructed (1 year) |
The Suzhou Second Academy | The man | 31 | Right hand back of the body hot crush injury | L.V.2.4mm×100mm | Unobstructed (1 year) |
Claims (4)
1. machine made synthetic small blood vessel, tube wall is characterized in that accompanying between per two strands of reeled yarns (1) 2 plain weaves (2) warp by being basic organizational structure with reeled yarn (1) and being formed by the aid in tissue structure with plain weave (2).
2. synthetic small blood vessel as claimed in claim 1, the diameter that it is characterized in that little blood vessel is 0.6mm, little blood vessel is smooth.
3. the little blood vessel of novel artificial comprises a kind of synthetical tube, it is characterized in that tube wall is by being basic organizational structure with reeled yarn (1) and being formed by the aid in tissue structure with twill (3).Accompany 3 twills (3) warp between per two strands of reeled yarns (1), accompany 1 or 2 parallels in the ring of reeled yarn (1).
4. synthetic small blood vessel as claimed in claim 3, the diameter that it is characterized in that little blood vessel is 2mm-4mm, little blood vessel is smooth.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN90107744A CN1033140C (en) | 1990-09-18 | 1990-09-18 | Machine made synthetic small blood vessel |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN90107744A CN1033140C (en) | 1990-09-18 | 1990-09-18 | Machine made synthetic small blood vessel |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1060023A CN1060023A (en) | 1992-04-08 |
CN1033140C true CN1033140C (en) | 1996-10-30 |
Family
ID=4880693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN90107744A Expired - Fee Related CN1033140C (en) | 1990-09-18 | 1990-09-18 | Machine made synthetic small blood vessel |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1033140C (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100345527C (en) * | 2003-02-21 | 2007-10-31 | 无锡莱福纶生物材料有限公司 | Machine knitting artificial blood vessel without pleat in the internal wall, and its making method |
CN100364489C (en) * | 2003-02-21 | 2008-01-30 | 无锡莱福纶生物材料有限公司 | Machine knitting artificial pleat-free blood vessel and its making method |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101084846B (en) * | 2007-03-21 | 2010-05-26 | 林增华 | Double-layer weaving polyester artificial vessel |
CN109106468B (en) * | 2018-08-14 | 2023-12-01 | 江苏百优达生命科技有限公司 | Artificial blood vessel structure capable of improving compliance |
CN113463243B (en) * | 2020-03-11 | 2023-08-18 | 浙江脉通智造科技(集团)有限公司 | Artificial blood vessel and preparation method thereof |
-
1990
- 1990-09-18 CN CN90107744A patent/CN1033140C/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100345527C (en) * | 2003-02-21 | 2007-10-31 | 无锡莱福纶生物材料有限公司 | Machine knitting artificial blood vessel without pleat in the internal wall, and its making method |
CN100364489C (en) * | 2003-02-21 | 2008-01-30 | 无锡莱福纶生物材料有限公司 | Machine knitting artificial pleat-free blood vessel and its making method |
Also Published As
Publication number | Publication date |
---|---|
CN1060023A (en) | 1992-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Blakemore et al. | The use of tubes constructed from vinyon “N” cloth in bridging arterial defects—experimental and clinical | |
Gelberman et al. | The revascularization of healing flexor tendons in the digital sheath. A vascular injection study in dogs. | |
Vaughan | The radial forearm free flap in orofacial reconstruction: personal experience in 120 consecutive cases | |
CN201617973U (en) | Bracket type artificial blood vessel for aortic operation | |
CN201782845U (en) | Stent type artificial vessel conveying device for aortic surgery | |
CN106109056B (en) | A kind of multi-cavity overlay film frame and its application method | |
CN2817766Y (en) | Separated standing blood vessel for prosthesis of aorta ascendens and aortic arches cavity | |
Crawford et al. | Clinical use of synthetic arterial substitutes in three hundred seventeen patients | |
CN1033140C (en) | Machine made synthetic small blood vessel | |
CN109833112A (en) | Bracket and its application method in a kind of art | |
CN2075073U (en) | Artificial small blood ressed weaved by machine | |
Takasugi et al. | Three-dimensional architecture of blood vessels of tendons demonstrated by corrosion casts | |
CN109199634A (en) | A kind of individuation branch stent type bow portion reconstruction artificial blood vessel | |
CN107049556A (en) | Pourable distal end belt supporting frame artificial blood vessel and arch of aorta drop portion artificial blood vessel | |
CN209347312U (en) | A kind of individuation branch stent type bow portion reconstruction artificial blood vessel | |
Campisi | The autologous vein grafts in reconstructive microsurgery for lymph stasis | |
Tanabe et al. | Surgical treatment of aortic dissection: application of Ivalon sponge to the dissected lumen | |
Knox et al. | Dacron® Grafts in the Treatment of Arteriosclerotic Occlusion of the Superficial Femoral Artery: Report of Seven Cases | |
Rothfield | Fibromuscular Arterial Disease | |
CN2449677Y (en) | Esophagus reconstruction device | |
Friedman et al. | Axillofemoral bypass graft fracture | |
Almany et al. | Radial artery access for diagnostic and interventional procedures | |
Badiger et al. | Bilateral High Division of Brachial Artery: A Case Report and Clinical Significance in Ayurvedic and Modern Medical Practice | |
Murray et al. | Diffuse aneurysmal degeneration of the femoropopliteal artery | |
RU2176482C2 (en) | Method for performing plastic repair of nerve trunk defect |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |