CN103300945A - Medical porous composite material - Google Patents
Medical porous composite material Download PDFInfo
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- CN103300945A CN103300945A CN2013102246923A CN201310224692A CN103300945A CN 103300945 A CN103300945 A CN 103300945A CN 2013102246923 A CN2013102246923 A CN 2013102246923A CN 201310224692 A CN201310224692 A CN 201310224692A CN 103300945 A CN103300945 A CN 103300945A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
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- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a medical porous composite material which comprises a winding-type porous base body and a reinforcement layer covering the winding-type porous base body, wherein the winding-type porous base body is formed by winding and knitting medical metal wires; through holes are filled up between the metal wires; nodes are formed at the lapping parts of the metal wires; the porosity of the winding-type porous base body is 30%-90%; the reinforcement layer is formed by polymerizing and curing medical high polymer materials onto the surfaces of the metal wires; the nodes are fixed, thereby enabling the metal wires to be permanently fixedly connected at the nodes; the volume fraction of the reinforcement layer is 0.5%-30%; and the porosity of the composite material is 20%-80%. The composite material is remarkably improved in mechanical property, is high in matching degree and excellent in bone conduction and induction properties with natural bones, and can be used as a bone implantation material with higher strength requirement in the fields of bone substitution, bone filling, bone repair and the like.
Description
Technical field
The present invention relates to a kind of high strength orthopaedics embedded material of transplanting for the damaged filling of bone and reparation and bone, be specifically related to a kind of medical porous composite, belong to technical field of biomedical materials,
Background technology
Orthopedic implanting material has become filling and the prosthesis institute indispensable material that bone is transplanted, bone is damaged at present, and clinical research in recent decades shows that the elastic modelling quantity of metal species bone implant material is most important for its result of use.Because the elastic modelling quantity between metal material and the people's bone there are differences, " stress shielding " phenomenon can appear in the embedded material, in order to address this problem, need to obtain the medical metal material of alap elastic modelling quantity, and the porous of solid material can significantly reduce elastic modelling quantity and the intensity of material.
The kind of present loose structure bone implant material has many, and wherein the winding-type porous material is complete three-dimensional through hole structure, because preparation technology is simple, cost is lower, especially has outstanding pliability and long fatigue life, makes it enjoy favor.But because elastic modelling quantity and yield strength are lower, this winding-type porous material is restricted in some stressed bigger orthopaedics application scenarios.
Summary of the invention
Technical problem to be solved by this invention is deficiency and the application limit thereof at existing winding-type porous orthopedic implanting material, a kind of medical porous composite of high-strength tenacity is provided, keeping outstanding flexible its elastic modelling quantity and the yield strength of significantly improving simultaneously, the elastic modelling quantity of this medical porous composite, intensity, aperture and porosity and natural bone have extraordinary matching degree, have lower preparation cost simultaneously.
The technical scheme that the present invention solves its technical problem is:
A kind of medical porous composite, it includes winding-type porous matrix and covering enhancement layer thereon, described winding-type porous matrix is formed by medical tinsel coiling braiding, be full of the hole that connects between this tinsel, and each mutual lap-joint wiry forms node, the porosity of this winding-type porous matrix is 30%-90%, described enhancement layer is formed in described surface wiry by the medical macromolecular materials polymerizing curable, and described node is fixed, make described tinsel form permanent fixedly connected at this node place, the volume fraction of this enhancement layer is 0.5%-30%, and the porosity of described composite is 20%-80%.
The tensile yield strength of described composite is 20KPa-90MPa, and tensile modulus of elasticity is 100KPa-20GPa, and comprcssive strength is 3.0MPa-180MPa, and modulus of elasticity in comperssion is 12MPa-25GPa.
Described tinsel is medical titanium silk, titanium alloy wire, stainless steel silk or tantalum wire, and its diameter is 0.01mm-3mm.
The medical macromolecular materials of described enhancement layer are polymethyl methacrylate, polylactic acid, poly-fumaric acid hydroxy propyl ester, polyhydroxy-alkanoate, polyethylene, silk fiber or carboxy methylation chitosan.
Described winding-type porous matrix is through the silane surface treatment.
The present invention is by compound with bioabsorbable polymer material, monomer solution in-situ polymerization between the node of winding-type porous matrix generates macromolecular material, perhaps Rong Hua polymer resolidification on this node, make winding-type porous matrix inside form the node of a plurality of permanent fixations, therefore compared with prior art, its beneficial effect is: the mechanical property that has greatly improved described medical porous composite; If the winding-type porous matrix is through the silane surface treatment before compound with bioabsorbable polymer material, perhaps improve the surface treatment of adhesion between reinforcing material and the matrix material through other, then can further improve intensity and the elastic modelling quantity of described medical porous composite.The present invention is keeping outstanding flexible its elastic modelling quantity and the intensity of having significantly improved simultaneously, its elastic modelling quantity, intensity, aperture and porosity and natural bone have extraordinary matching degree, described medical porous composite has good bone conduction and bone inducing properties, has lower preparation cost simultaneously, can be prepared into bone implant material or the prosthetic material of different shape, various sizes easily, be used as the orthopedic implanting material higher to requirement of strength in the fields such as bone substitutes, bone filling, bone reparation.
Description of drawings
Fig. 1 is the sketch map of winding-type porous matrix of the present invention.
Fig. 2 is partial schematic diagram of the present invention.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is elaborated.
The present invention is a kind of medical porous composite, and it includes winding-type porous matrix and enhancement layer, this enhancement layer be covered in the winding-type porous matrix above.
See also Fig. 1, described winding-type porous matrix adopts conventional coiling weaving machinery and conventional winding process coiling braiding to form by medical tinsel.Be full of the hole that connects between this tinsel, and each mutual lap-joint wiry formation node, the porosity of this winding-type porous matrix is 30%-90%.Described medical tinsel is medical titanium silk, titanium alloy wire, stainless steel silk or tantalum wire, and its diameter range is 0.01mm-3mm.
Described winding-type porous matrix can pass through the silane surface treatment before compound with medical macromolecular materials, perhaps improve the surface treatment of adhesion between reinforcing material and the matrix material through other, the improvement of this adhesion can further improve intensity and the elastic modelling quantity of described medical porous composite, and pliability can not reduce simultaneously.
See also Fig. 2 winding-type porous matrix and the medical macromolecular materials partial structurtes sketch map of the present invention after compound.Described enhancement layer is formed in described surface wiry by the medical macromolecular materials polymerizing curable, and with the node fixation that described each tinsel overlaps mutually, sees arrow indication place among Fig. 2, makes described tinsel form permanent fixedly connected at this node place.The material of described enhancement layer is one of following medical macromolecular materials: polymethyl methacrylate (PMMA), polylactic acid (PLA), poly-fumaric acid hydroxy propyl ester (PPF), polyhydroxy-alkanoate (PHA), polyethylene, silk fiber, carboxy methylation chitosan class medical macromolecular materials, what the combination process of these medical macromolecular materials on the tinsel adopted is the conventional polymerizing curable technology of corresponding medical macromolecular materials, and specifically row embodiment is described as follows.The volume fraction of this enhancement layer after compound, namely enhancement layer volume proportion in described medical porous composite is 0.5%-30%.
The porosity of described medical porous composite is 20%-80%; Tensile yield strength is 20KPa-90MPa, and tensile modulus of elasticity is 100KPa-20GPa; Comprcssive strength is 3.0MPa-180MPa, and modulus of elasticity in comperssion is 12MPa-25GPa.
It below is specific embodiment; below each embodiment only be used for explanation composite porous formation of the present invention and preparation; but not limiting the scope of the invention; those skilled in the art can also make various conversion under the situation that does not break away from thinking of the present invention and scope; therefore all are equal to the present invention and equivalent technical scheme also should belong to category of the present invention, and its technical scheme by claims is limited.
Embodiment one
Adopting diameter is the medical grade titanium silk of 0.27mm, turn to the winding-type titanium porous matrix of setting shape and setting porosity with the coiling braider, its porosity is 55%, be full of the hole that connects between this titanium silk, pore diameter range is at 0-700 μ m, mean pore size is at 267 μ m, and the mutual lap-joint of each titanium silk forms node; The tensile modulus of elasticity of this winding-type titanium porous matrix is 0.015GPa, and tensile yield strength is 3.5MPa, and modulus of elasticity in comperssion is 0.032GPa, and comprcssive strength is 25MPa.Adopt the PMMA(polymethyl methacrylate then) as reinforcing material, winding-type titanium porous matrix is dipped in the MMA monomer solution that is mixed with initiator, handle 1.5h for 85 ℃, take out sample and put into 50 ℃ of constant temperature processing of resistance furnace 24h, obtain compound medical porous composite, the porosity of this medical porous composite is 53.4%, and pore diameter range is at 100-700 μ m, and mean pore size is at 375 μ m; The tensile modulus of elasticity of described medical porous composite is 1.02GPa, and tensile yield strength is 4.5MPa, and modulus of elasticity in comperssion is 0.32GPa, and comprcssive strength is 50MPa.The mechanical property of this porous composite titanium material has had than winding-type titanium porous matrix and has increased substantially, and it has relative higher modulus of elasticity, and the bone that is fit to intensity is had higher requirements is repaired occasion.
Embodiment two
Adopting the diameter of medical grade is the titanium silk of 2.0mm, preparing porosity with the coiling weaving machinery is 30% winding-type titanium porous matrix, be full of the hole that connects between the titanium silk, the mutual lap-joint of each titanium silk forms node, the tensile modulus of elasticity of this winding-type titanium porous matrix is 335MPa, tensile yield strength is 56MPa, and modulus of elasticity in comperssion is 662MPa, and comprcssive strength is 78MPa.Adopt high density polyethylene (HDPE) as reinforcing material then, in annular-pipe reactor under 15-30 atmospheric middle pressures, to be soaked with the vinyl monomer of winding-type titanium porous matrix under the condition of chromium-based catalysts, carry out the Ziegler-Natta high density polyethylene (HDPE) that is polymerized, by the control technological parameter, make high density polyethylene (HDPE) mainly concentrate near the node of winding-type titanium porous matrix, make the node of winding-type titanium porous matrix inside fix, the volume fraction of the material of enhancement layer is 10% at this moment; The porosity of described medical porous composite is 30%, and its tensile modulus of elasticity is 20GPa, and tensile yield strength is 90MPa, and modulus of elasticity in comperssion is 25GPa, and comprcssive strength is 180MPa.This medical porous composite good biocompatibility, the bone replacement operation that is suitable for having relatively high expectations.
Embodiment three
Adopting the diameter of medical grade is the titanium alloy wire of 0.10mm, preparing porosity with the coiling weaving machinery is 75% winding-type titanium alloy porous matrix, be full of the hole that connects between this tinsel, and each mutual lap-joint wiry forms node, the tensile modulus of elasticity of winding-type titanium alloy porous matrix is 3.0MPa, tensile yield strength is 0.8MPa, and modulus of elasticity in comperssion is 5.4MPa, and comprcssive strength is 7.3MPa.Adopt the carboxy methylation chitosan as reinforcing material then, O-CM chitin crude product is added in the NaOH alkali liquor, deacetylation 90min under 100 ℃ of nitrogen protections, product is filtered, wash with excess ethanol, clean with acetone then, namely get O-CM chitosan crude product behind the drying under reduced pressure, the crude product that obtains dissolves with pure water, remove impurity by centrifugalize, by dialyzer dialysis 5d, winding-type titanium alloy porous matrix is immersed the aqueous solution that obtains again, reuse rotary evaporator concentrates, the control technological parameter, through the lyophilization of 2d, obtain the fixing medical porous composite of node, this moment, the volume fraction of enhancement layer was 30%; The porosity of described medical porous composite is 45%, and tensile modulus of elasticity is 32MPa, and tensile yield strength is 1.9MPa, and modulus of elasticity in comperssion is 176MPa, and comprcssive strength is 35.2MPa.This medical porous composite good biocompatibility, Stability Analysis of Structures is suitable for bone tissue restoration.
Embodiment four
Adopting the diameter of medical grade is the tantalum wire of 0.10mm, preparing porosity with the coiling weaving machinery is 35% winding-type tantalum porous matrix, its tensile modulus of elasticity is 0.05GPa, tensile yield strength is 5.2MPa, modulus of elasticity in comperssion is 99.2MPa, comprcssive strength is 13.2MPa, has been full of the hole that connects between this tantalum wire, and the mutual lap-joint of each tantalum wire forms node.Adopt polylactic acid (PLA) as reinforcing material then, become monomer by lactide open loop in acetone, add catalyst and initiator subsequently, by the control process conditions, 120 ℃ of constant temperature are handled 24h in nitrogen atmosphere, obtain the fixing medical porous composite of node, this moment, the volume fraction of enhancement layer was 15%; The porosity of described medical porous composite is 20%, and tensile modulus of elasticity is 2.14GPa, and tensile yield strength is 7.7MPa, and modulus of elasticity in comperssion is 4.4GPa, and comprcssive strength is 120MPa.This medical tantalum is composite porous to have a higher modulus of elasticity, and owing to adopt degradable polylactic acid as bridging agent, good biocompatibility, the bone that is suitable for having relatively high expectations is implanted occasion.
Embodiment five
Adopting diameter is the medical grade 316L stainless steel silk of 0.01mm, preparing porosity with the coiling weaving machinery is 90% winding-type porous matrix, be full of the hole that connects between its tinsel, and each mutual lap-joint wiry forms node, the tensile modulus of elasticity of described winding-type porous matrix is 100KPa, tensile yield strength is 20KPa, and modulus of elasticity in comperssion is 0.5MPa, and comprcssive strength is 0.9MPa.Adopt natural silk as strengthening body then, the sericin on natural silk surface is removed with the aqueous sodium carbonate that boils, obtain fibroin, oven dry, dissolve with lithium-bromide solution at last, the winding-type porous matrix of high porosity is immersed in this solution, by the control technological parameter, handle at-60 ℃ of constant temperature, obtain the fixing medical porous composite of node of high porosity, this moment, the volume fraction of enhancement layer was 10%, the porosity of described medical porous composite is 80%, and tensile modulus of elasticity is 305KPa, and tensile yield strength is 108KPa, modulus of elasticity in comperssion is 12MPa, and comprcssive strength is 3MPa.This medical porous composite is higher owing to its porosity, good biocompatibility, and the fibroin degradation speed is slow, and the Stability Analysis of Structures mechanical property is moderate, is suitable for the part bone tissue restoration.
Embodiment six
Adopting the diameter of medical grade is the stainless steel silk of 3.0mm, preparing porosity with the coiling weaving machinery is 80% winding-type porous matrix, be full of the hole that connects between its tinsel, and each mutual lap-joint wiry forms node, the tensile modulus of elasticity of this winding-type porous matrix is 50MPa, tensile yield strength is 8.6MPa, and modulus of elasticity in comperssion is 124MPa, and comprcssive strength is 18MPa.Adopt polyhydroxy-alkanoate (PHA) as reinforcing material then, the winding-type porous matrix is mixed in the prepolymer of binary acid and excessive acetic acid anhydride reactant generation diacid, make diacid pre-polymerization melt polycondensation by the control parameter, vacuum is sloughed acetic anhydride and is obtained high polymer, make the high polymer that obtains mainly near node, obtain the fixing medical porous composite of node, this moment, the volume fraction of enhancement layer was 0.5%, the porosity of described medical porous composite is 79.5%, tensile modulus of elasticity is 1.2GPa, tensile yield strength is 9.6MPa, and modulus of elasticity in comperssion is 2.6GPa, and comprcssive strength is 95MPa.This medical porous composite property is stable, has excellent biological compatibility, and reinforcing material has surface of good corrosion degradation characteristic, and degradation speed is adjustable, is suitable for the bone tissue restoration higher to mechanical property requirements.
Embodiment seven
Adopting the diameter of medical grade is the stainless steel silk of 1.0mm, preparing porosity with the coiling weaving machinery is 40% winding-type porous matrix, be full of the hole that connects between its tinsel, and each mutual lap-joint wiry forms node, the tensile modulus of elasticity of this winding-type porous matrix is 90.3MPa, tensile yield strength is 10.5MPa, and modulus of elasticity in comperssion is 176MPa, and comprcssive strength is 21.2MPa.Adopt poly-fumaric acid two hydroxypropyl acrylates (PPF) as reinforcing material then, fumaric acid is dissolved in hexone, logical N
2, electromagnetic agitation, oil bath is heated to 90 ℃, begins to drip expoxy propane, and keeps 90 ℃ of reaction temperature to reaction solutions to clarify substantially, stopped reaction behind the continuation reaction 0.5h, and naturally cool to room temperature, will react gained solution Na
2HPO
4Solution washing, separatory are used KCl solution washing, separatory twice more respectively, namely get thick product at last, with thick product in N
2Distilling under reduced pressure in the atmosphere, the desolventizing hexone namely gets performed polymer PFP, gets PFP and places there-necked flask, adds Sb
2O
3As catalyst, add the winding-type porous matrix simultaneously, logical N
2And the electromagnetic agitation oil bath is heated to 160 ℃, stops behind the reaction 6h, then product is dissolved in oxolane, and the supernatant is got in centrifugalize, and repeated centrifugation is separated to Sb
2O
3All remove, again clear liquid distilling under reduced pressure to solvents tetrahydrofurane is all removed, in this process, control technological parameter, make liquid state gather near the main polymerization node of winding-type porous matrix of fumaric acid two hydroxypropyl acrylates (PPF), obtain the fixing medical porous composite of node, this moment enhancement layer volume fraction for being 2.7%.The porosity of described medical porous composite is 37.3%, and tensile modulus of elasticity is 7.8GPa, and tensile yield strength is 56MPa, and modulus of elasticity in comperssion is 17.2GPa, and comprcssive strength is 93MPa.This medical porous composite good biocompatibility is suitable for the bone tissue restoration higher to mechanical property requirements.
Embodiment eight
Adopting diameter is the medical grade tantalum wire of 0.01mm, preparing porosity with the coiling weaving machinery is 90% winding-type tantalum porous matrix, its tensile modulus of elasticity is 0.05GPa, tensile yield strength is 5.2MPa, modulus of elasticity in comperssion is 0.4MPa, comprcssive strength is 0.75MPa, has been full of the hole that connects between this tantalum wire, and the mutual lap-joint of each tantalum wire forms node; Described winding-type tantalum porous matrix passed through the silane surface treatment earlier before compound with medical macromolecular materials, to improve the adhesion between reinforcing material and the matrix material.Adopt polylactic acid (PLA) as reinforcing material then, become monomer by lactide open loop in acetone, add catalyst and initiator subsequently, by the control process conditions, 120 ℃ of constant temperature are handled 24h in nitrogen atmosphere, obtain the fixing medical porous composite of node, this moment, the volume fraction of enhancement layer was 4%; The porosity of described medical porous composite is 70%, and tensile modulus of elasticity is 100KPa, and tensile yield strength is 20KPa, and modulus of elasticity in comperssion is 12MPa, and comprcssive strength is 30MPa.The degradable polylactic acid of the composite porous employing of this medical tantalum is as bridging agent, good biocompatibility, and the bone that is suitable for having relatively high expectations is implanted occasion.
Claims (6)
1. medical porous composite, it is characterized in that: described composite includes winding-type porous matrix and covering enhancement layer thereon, described winding-type porous matrix is formed by medical tinsel coiling braiding, be full of the hole that connects between this tinsel, and each mutual lap-joint wiry forms node, the porosity of this winding-type porous matrix is 30%-90%, described enhancement layer is formed in described surface wiry by the medical macromolecular materials polymerizing curable, and described node is fixed, make described tinsel form permanent fixedly connected at this node place, the volume fraction of this enhancement layer is 0.5%-30%, and the porosity of described composite is 20%-80%.
2. medical porous composite according to claim 1, it is characterized in that: the tensile yield strength of described composite is 20KPa-90MPa, tensile modulus of elasticity is 100KPa-20GPa, and comprcssive strength is 3.0MPa-180MPa, and modulus of elasticity in comperssion is 12MPa-25GPa.
3. medical porous composite according to claim 1 and 2, it is characterized in that: described tinsel is medical titanium silk, titanium alloy wire, stainless steel silk or tantalum wire.
4. medical porous composite according to claim 1 and 2, it is characterized in that: described diameter wiry is 0.01mm-3mm.
5. medical porous composite according to claim 1 and 2 is characterized in that: the medical macromolecular materials of described enhancement layer are polymethyl methacrylate, polylactic acid, poly-fumaric acid hydroxy propyl ester, polyhydroxy-alkanoate, polyethylene, silk fiber or carboxy methylation chitosan.
6. medical porous composite according to claim 1 is characterized in that: the surface treatment of described winding-type porous matrix process silane.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104476885A (en) * | 2014-12-22 | 2015-04-01 | 宏祥新材料股份有限公司 | Nano-alloy polymer double-proofing film and preparation technology thereof |
| CN104587533A (en) * | 2014-06-26 | 2015-05-06 | 段然 | Large grain tantalum wire for osteosynthesis |
| CN105056304A (en) * | 2015-08-31 | 2015-11-18 | 中原工学院 | Multi-layer nanofiber fabric reinforced bone biomimetic material and preparation method thereof |
| CN106178104A (en) * | 2016-08-29 | 2016-12-07 | 上海交通大学 | A kind of medical medicine-carried porous polyether-ether-ketone and manufacture method thereof and application |
| CN106794280A (en) * | 2014-10-14 | 2017-05-31 | 安东尼奥·桑布瑟蒂 | For the absorbable device of osteanagenesis |
| CN111388757A (en) * | 2020-03-21 | 2020-07-10 | 哈尔滨工程大学 | Degradable magnesium-based composite material prepared from spiral magnesium wires |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291169B2 (en) * | 2005-04-15 | 2007-11-06 | Zimmer Technology, Inc. | Cartilage implant |
| US20070276489A1 (en) * | 2003-06-05 | 2007-11-29 | Bindseil James J | Fusion implant and method of making same |
| CN101163461A (en) * | 2005-02-22 | 2008-04-16 | 光碟-O-特克医学科技有限公司 | Methods, materials and apparatus for treating bone and other tissue |
| CN101181646A (en) * | 2007-12-06 | 2008-05-21 | 上海交通大学 | Method for preparing toughened cemented metal netted polyporous material |
| CN101543437A (en) * | 2009-04-29 | 2009-09-30 | 乐普（北京）医疗器械股份有限公司 | Method for preparing intravascular stent |
| CN101617965A (en) * | 2008-06-30 | 2010-01-06 | 北京圣玛特科技有限公司 | Preparation method and product of biomedical porous implantation body |
| CN102725006A (en) * | 2009-10-07 | 2012-10-10 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
-
2013
- 2013-06-06 CN CN2013102246923A patent/CN103300945A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070276489A1 (en) * | 2003-06-05 | 2007-11-29 | Bindseil James J | Fusion implant and method of making same |
| CN101163461A (en) * | 2005-02-22 | 2008-04-16 | 光碟-O-特克医学科技有限公司 | Methods, materials and apparatus for treating bone and other tissue |
| US7291169B2 (en) * | 2005-04-15 | 2007-11-06 | Zimmer Technology, Inc. | Cartilage implant |
| CN101181646A (en) * | 2007-12-06 | 2008-05-21 | 上海交通大学 | Method for preparing toughened cemented metal netted polyporous material |
| CN101617965A (en) * | 2008-06-30 | 2010-01-06 | 北京圣玛特科技有限公司 | Preparation method and product of biomedical porous implantation body |
| CN101543437A (en) * | 2009-04-29 | 2009-09-30 | 乐普（北京）医疗器械股份有限公司 | Method for preparing intravascular stent |
| CN102725006A (en) * | 2009-10-07 | 2012-10-10 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
Non-Patent Citations (1)
| Title |
|---|
| 谭庆彪: ""缠绕金属丝材料的制备、性能及对铝基体的强化行为"", 《中国博士学位论文全文数据库 工程科技Ⅰ辑》, no. 10, 15 October 2012 (2012-10-15), pages 020 - 70 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587533A (en) * | 2014-06-26 | 2015-05-06 | 段然 | Large grain tantalum wire for osteosynthesis |
| CN106794280A (en) * | 2014-10-14 | 2017-05-31 | 安东尼奥·桑布瑟蒂 | For the absorbable device of osteanagenesis |
| CN104476885A (en) * | 2014-12-22 | 2015-04-01 | 宏祥新材料股份有限公司 | Nano-alloy polymer double-proofing film and preparation technology thereof |
| CN105056304A (en) * | 2015-08-31 | 2015-11-18 | 中原工学院 | Multi-layer nanofiber fabric reinforced bone biomimetic material and preparation method thereof |
| CN106178104A (en) * | 2016-08-29 | 2016-12-07 | 上海交通大学 | A kind of medical medicine-carried porous polyether-ether-ketone and manufacture method thereof and application |
| CN111388757A (en) * | 2020-03-21 | 2020-07-10 | 哈尔滨工程大学 | Degradable magnesium-based composite material prepared from spiral magnesium wires |
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