CN103285430A - Preparation method of modified silicone rubber - Google Patents
Preparation method of modified silicone rubber Download PDFInfo
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- CN103285430A CN103285430A CN2012100492420A CN201210049242A CN103285430A CN 103285430 A CN103285430 A CN 103285430A CN 2012100492420 A CN2012100492420 A CN 2012100492420A CN 201210049242 A CN201210049242 A CN 201210049242A CN 103285430 A CN103285430 A CN 103285430A
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- silicone rubber
- endometrium
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Abstract
The invention discloses a preparation method of modified silicone rubber. The method comprises the following steps: by using silicone rubber as a raw material, adding 0.1-20wt% of estrogen, stirring for 5-30 minutes at room temperature, and uniformly mixing; then, adding a mixed vulcanizing agent to the mixed system, continuously stirring for 5-20 minutes and then paving a film under panel glass and drying; finally, vulcanizing and furnace-cooling at 100-300 DEG C. The silicone rubber prepared by the method has the function of preventing intrauterine adhesion and accelerating the recovery of endometrium.
Description
Technical field
The present invention relates to a kind of preparation method of modified silicon rubber.
Background technology
Silicone rubber is because its good physical property and bio-compatible performance, inertia, nontoxic, not carcinogenic, anti-biological aging, minimum to the tissue reaction, can not cause foreign body reaction behind the implant into body tissue, surrounding tissue is not inflamed, thereby has obtained using widely at biomedical aspect.Applicant of the present invention is applied to silastic material Asherman's syndrom curing equipment (patent No. ZL200820052366.3) first.The independent intellectual property right that this device has for applicant of the present invention.This device has its unique shape design.The one, the shape of its profile and uterine cavity fits like a glove, and the uterine cavity shape after such design can guarantee to treat can maintain normal form; The 2nd, be an extremely thin thin film in the profile of its palace shape, this thin film can avoid the front and rear wall of uterine cavity to be in contact with one another fully, thereby avoid the generation again of intrauterine adhesion fully, because very thin of its thin film can produce hardly to endometrial compressing and mechanical damage.Inner membrance is just had an opportunity to regenerate and is covered the surface of uterine cavity again on the adhesion wound surface that separates like this, thereby thoroughly cures intrauterine adhesion.
Applicant of the present invention implants the intrauterine of sheep with the silicone rubber of this peculiar structure, and experimental result shows that the bio-compatible performance of this material is good, and the endometrium phenomenon of adhesion does not again take place.But, because after the Asherman's syndrom curing operation, endometrium is subjected to wound largely, recover slower, and want the long-term oral medicine that helps endometrium to recover, implantation person is caused the increase for the treatment of cost and the misery on the health, and cause the generation of other diseases easily.Simultaneously, cure the conceived requirement in back because Most patients has, so the rehabilitation as early as possible in adversary's postoperative uterus there is specific requirement.
Summary of the invention
The objective of the invention is in medical grade silicon rubber, add estrogen by the blending additive process, thereby obtain a kind of good biocompatibility, also have the medical grade silicon rubber material that promotes the rehabilitation of postoperative endometrium simultaneously.
Specifically, add in the feed liquor body silicone rubber having the estrogen that promotes the rehabilitation of postoperative endometrium exactly, utilize the excellent biological compatibility energy of silicone rubber own simultaneously, make that the silicone rubber after the modification has the function that prevents intrauterine adhesion and promote the endometrium recovery.
Silastic material of the present invention is the medical use liquid silastic material, appearance transparent, and range of viscosities is at 200～1000Pa.s, and density range is at 1.0～1.2g/cm
3
Estrogen of the present invention is for circulation on the market has also entered the estrogen of clinical practice.
Technical scheme is as follows:
Be raw material with silicone rubber, the estrogen that adds 0.1～20wt%, stirred under the room temperature 5～30 minutes, mix homogeneously will mix vulcanizing agent again and add mixed system, keep stirring 5～20 minutes, follow plastic film mulch, drying under plate glass, the last back furnace cooling that vulcanizes under 100～300 ℃ condition can obtain good biocompatibility, also has the medical grade silicon rubber material that promotes the rehabilitation of postoperative endometrium simultaneously.
Promote the silastic material of postoperative endometrium rehabilitation to implant in the animal body having of the present invention's preparation, the area that 10～100 days newborn endometrial tissues is covered the cavity of uterus wall is measured, the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 1～50%.The estrogenic silastic material of interpolation of above test result proof the present invention preparation has good bio-compatible performance and promotes the effect that endometrium is repaired.
The specific embodiment
The present invention is further elaborated below in conjunction with embodiment.
Embodiment 1
Be raw material with silicone rubber, add the estrogen of 0.1wt%, stirred 5 minutes under the room temperature, mix homogeneously will mix vulcanizing agent again and add mixed system, keep stirring 5 minutes, then plastic film mulch, drying under plate glass are vulcanized the back furnace cooling at last under 100 ℃ condition.Promote the silastic material of postoperative endometrium rehabilitation to implant in the animal body having of the present invention's preparation, the area that 10 days newborn endometrial tissues is covered the cavity of uterus wall is measured, the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 1%.The area that 30 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 3%.The area that 100 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 5%.
Embodiment 2
Be raw material with silicone rubber, add the estrogen of 5wt%, stirred 15 minutes under the room temperature, mix homogeneously will mix vulcanizing agent again and add mixed system, keep stirring 15 minutes, then plastic film mulch, drying under plate glass are vulcanized the back furnace cooling at last under 200 ℃ condition.Promote the silastic material of postoperative endometrium rehabilitation to implant in the animal body having of the present invention's preparation, the area that 10 days newborn endometrial tissues is covered the cavity of uterus wall is measured, the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 10%.The area that 50 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 9%.The area that 100 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 23%.
Embodiment 3
Be raw material with silicone rubber, add the estrogen of 15wt%, stirred 30 minutes under the room temperature, mix homogeneously will mix vulcanizing agent again and add mixed system, keep stirring 20 minutes, then plastic film mulch, drying under plate glass are vulcanized the back furnace cooling at last under 300 ℃ condition.Promote the silastic material of postoperative endometrium rehabilitation to implant in the animal body having of the present invention's preparation, the area that 10 days newborn endometrial tissues is covered the cavity of uterus wall is measured, the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 18%.The area that 60 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 28%.The area that 100 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 33%.
Embodiment 4 is raw material with silicone rubber, adds the estrogen of 20wt%, stirs 20 minutes under the room temperature, mix homogeneously will mix vulcanizing agent again and add mixed system, keep stirring 20 minutes, then plastic film mulch, drying under plate glass are vulcanized the back furnace cooling at last under 250 ℃ condition.Promote the silastic material of postoperative endometrium rehabilitation to implant in the animal body having of the present invention's preparation, the area that 10 days newborn endometrial tissues is covered the cavity of uterus wall is measured, the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 22%.The area that 40 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 36%.The area that 100 days newborn endometrial tissues is covered the cavity of uterus wall is measured, and the result shows that implanting the estrogenic silicone rubber of interpolation does not add estrogenic silicone rubber with respect to implanting, and the speed that endometrium is recovered has increased by 50%.
Claims (2)
1. the preparation method of a modified silicon rubber, it is characterized in that, be raw material with silicone rubber, add the estrogen of 0.1～20wt%, stirred mix homogeneously under the room temperature 5～30 minutes, to mix vulcanizing agent again and add mixed system, keep stirring 5～20 minutes, then plastic film mulch, drying under plate glass, sulfuration back furnace cooling under 100～300 ℃ condition at last.
2. according to the preparation method of a kind of modified silicon rubber of claim 1, it is characterized in that silastic material is the medical use liquid silastic material, range of viscosities is at 200～1000Pa.s, and density range is at 1.0～1.2g/cm
3
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100492420A CN103285430A (en) | 2012-02-29 | 2012-02-29 | Preparation method of modified silicone rubber |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100492420A CN103285430A (en) | 2012-02-29 | 2012-02-29 | Preparation method of modified silicone rubber |
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| Publication Number | Publication Date |
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| CN103285430A true CN103285430A (en) | 2013-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012100492420A Pending CN103285430A (en) | 2012-02-29 | 2012-02-29 | Preparation method of modified silicone rubber |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105014834A (en) * | 2015-08-24 | 2015-11-04 | 中国人民解放军第三军医大学第二附属医院 | Application of microgroove forming mold in preparation of silicone rubber with microgroove pattern on surface |
| CN109925537A (en) * | 2018-04-19 | 2019-06-25 | 易浦润（上海）生物技术有限公司 | A kind of elastic membrane, preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5888441A (en) * | 1988-08-24 | 1999-03-30 | Ansell Healthcare Products Inc. | Preparation of antimicrobial articles |
| CN1403172A (en) * | 2001-09-07 | 2003-03-19 | 上海市计划生育科学研究所 | Medicine release controller for treating women's climacteric syndrome |
| CN1548014A (en) * | 2003-05-08 | 2004-11-24 | 上海市计划生育科学研究所 | Making process of intrauterine medicine releasing device |
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2012
- 2012-02-29 CN CN2012100492420A patent/CN103285430A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888441A (en) * | 1988-08-24 | 1999-03-30 | Ansell Healthcare Products Inc. | Preparation of antimicrobial articles |
| CN1403172A (en) * | 2001-09-07 | 2003-03-19 | 上海市计划生育科学研究所 | Medicine release controller for treating women's climacteric syndrome |
| CN1548014A (en) * | 2003-05-08 | 2004-11-24 | 上海市计划生育科学研究所 | Making process of intrauterine medicine releasing device |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105014834A (en) * | 2015-08-24 | 2015-11-04 | 中国人民解放军第三军医大学第二附属医院 | Application of microgroove forming mold in preparation of silicone rubber with microgroove pattern on surface |
| CN109925537A (en) * | 2018-04-19 | 2019-06-25 | 易浦润（上海）生物技术有限公司 | A kind of elastic membrane, preparation method and application |
| CN109925538A (en) * | 2018-04-19 | 2019-06-25 | 易浦润（上海）生物技术有限公司 | A kind of elastic membrane, preparation method and application |
| CN109925539A (en) * | 2018-04-19 | 2019-06-25 | 易浦润（上海）生物技术有限公司 | A kind of elastic membrane, preparation method and application |
| WO2019200694A1 (en) * | 2018-04-19 | 2019-10-24 | 易浦润（上海）生物技术有限公司 | Elastic membrane having function of reactivating endometrium basal layer in uterine cavity and preparation method for elastic membrane |
| JP2020534039A (en) * | 2018-04-19 | 2020-11-26 | 易浦潤（上海）生物技術有限公司 | An elastic membrane used in the uterine cavity and having a function of reactivating the endometrial base layer and a method for producing the same. |
| EP3639864A4 (en) * | 2018-04-19 | 2021-03-10 | Yipurun (Shanghai) Biotechnology Co., Ltd. | Elastic membrane having function of reactivating endometrium basal layer in uterine cavity and preparation method for elastic membrane |
| CN112494464A (en) * | 2018-04-19 | 2021-03-16 | 易浦润（上海）生物技术有限公司 | Elastic film and preparation method thereof |
| JP2022002751A (en) * | 2018-04-19 | 2022-01-11 | 易浦潤（上海）生物技術有限公司 | Elastic film provided with function of reactivating inner film base layer used in uterus intracavitary and its manufacturing method |
| CN109925537B (en) * | 2018-04-19 | 2022-03-01 | 易浦润（上海）生物技术有限公司 | Elastic membrane, preparation method and application thereof |
| CN109925538B (en) * | 2018-04-19 | 2022-03-01 | 易浦润（上海）生物技术有限公司 | Elastic membrane, preparation method and application thereof |
| JP7033342B2 (en) | 2018-04-19 | 2022-03-10 | 易浦潤（上海）生物技術有限公司 | An elastic membrane used in the uterine cavity and having a function of reactivating the endometrium base layer and a method for producing the same. |
| JP7245552B2 (en) | 2018-04-19 | 2023-03-24 | 易浦潤（上海）生物技術有限公司 | ELASTIC MEMBRANE WITH FUNCTION TO REACTIVATE INTIMUM BASE LAYER USED IN UTERINE CALM AND METHOD FOR MANUFACTURING THE SAME |
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Application publication date: 20130911 |