CN103271740A - Nuclear magnetic resonance imaging method and system - Google Patents
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Abstract
本发明涉及一种核磁共振成像方法和系统。该核磁共振成像方法包括通过导航模块检测是否满足预定的扫描条件;在符合扫描条件时,通过扫描模块对待成像区域进行扫描并采集数据;发出呼吸提醒信息,并通过导航模块继续检测是否满足预定的扫描条件;依据该数据进行成像。本发明核磁共振成像方法和系统能够使患者依据呼吸提示信息配合本发明进行检测,呼吸提示信息能够依据预设的规则提醒患者进行呼吸运动,使得扫描成像时能够有效规避因为呼吸运动带来的误差,从而使得本方法的成像精度较高。
The invention relates to a nuclear magnetic resonance imaging method and system. The nuclear magnetic resonance imaging method includes detecting whether the predetermined scanning conditions are met through the navigation module; when the scanning conditions are met, scanning the area to be imaged and collecting data through the scanning module; sending a breathing reminder message, and continuing to detect whether the predetermined scanning conditions are met through the navigation module. Scanning conditions; imaging based on this data. The MRI method and system of the present invention can enable the patient to perform detection according to the breathing prompt information in cooperation with the present invention, and the breathing prompt information can remind the patient to perform breathing exercise according to the preset rules, so that the scanning and imaging can effectively avoid errors caused by breathing movement , so that the imaging precision of this method is higher.
Description
技术领域technical field
本发明涉及一种医学成像方法,特别是一种核磁共振成像方法。The invention relates to a medical imaging method, in particular to a nuclear magnetic resonance imaging method.
此外,本发明还涉及一种医学成像系统,尤其是一种核磁共振成像系统。In addition, the present invention also relates to a medical imaging system, especially a nuclear magnetic resonance imaging system.
背景技术Background technique
随着医疗技术的发展,核磁共振成像(Magnetic Resonance Imaging,MRI)设备日益成为一种检测大病、要病的一种重要设备。通过核磁共振成像获得身体内部器官的医学影像,可以为医生确定患者的病情提供重要情报。With the development of medical technology, magnetic resonance imaging (Magnetic Resonance Imaging, MRI) equipment has increasingly become an important equipment for detecting serious and critical diseases. Medical images of the internal organs of the body obtained through MRI can provide vital information for doctors to determine a patient's condition.
通常,核磁共振成像有两种重要的功能成像方法:一个是扩散加权成像(Diffusion Weighted Imaging,DWI),另一个是动态增强成像(DynamicContrast-enhanced magnetic resonance imaging,DCE)。这两种成像方法所获得医学影像的精准程度,成为评价核磁共振成像的重要指标。Generally, MRI has two important functional imaging methods: one is Diffusion Weighted Imaging (DWI), and the other is Dynamic Contrast-enhanced magnetic resonance imaging (DCE). The accuracy of medical images obtained by these two imaging methods has become an important indicator for evaluating MRI.
以人体肝脏的DWI或者DCE为例,影响肝脏DWI和DCE的精准的主要原因源自人的呼吸。人呼吸时,肝脏会随着呼吸发生位置移动。肝脏在成像过程中的位移会导致严重的伪影,从而使得成像结果有较大误差。Taking the DWI or DCE of the human liver as an example, the main reason affecting the accuracy of DWI and DCE of the liver comes from human breathing. When a person breathes, the liver moves with the breathing. The displacement of the liver during the imaging process will cause serious artifacts, which will cause large errors in the imaging results.
以肝DWI采集技术为例,现有技术中,肝DWI采集技术包括自由呼吸技术(free-breath)、单次屏气技术(Single-shot)、呼吸门控技术(respiratory-gated)和呼吸导航技术(navigator)等。Taking liver DWI acquisition technology as an example, in the prior art, liver DWI acquisition technology includes free-breath technology (free-breath), single-breath-hold technology (Single-shot), respiratory-gated technology (respiratory-gated) and respiratory navigation technology (navigator) and so on.
自由呼吸DWI显然有明显的运动信息。单次屏气DWI虽能最大程度减小运动的影响,但有图像信噪比低、扫描层厚较厚等缺点,且很多患者在屏气后期往往有小幅度的呼吸运动,因此也有部分运动伪影影响。Free-breathing DWI clearly has significant motion information. Although single-breath-hold DWI can minimize the impact of motion, it has disadvantages such as low image signal-to-noise ratio and thick scan slices, and many patients often have small breathing movements in the late stage of breath-hold, so there are also some motion artifacts Influence.
呼吸门控DWI和呼吸导航DWI技术虽在膈肌运动幅度最小时采集图像,可一定程度减少运动伪影,但这两种方法的采集时间窗内,肝脏和膈肌仍然有运动,运动伪影情况依然严峻。并且,DWI数据采集多为多次采集(多个NEX,number of excitations),在容积内各NEX之间必然存在运动不完全一致,而核磁共振扫描机在重建图像时是把多次NEX采集的数据进行平均后重建而成,因此,DWI的图像含有运动伪影的信息。Respiratory-gated DWI and respiratory-navigated DWI can reduce motion artifacts to a certain extent by acquiring images when the diaphragm’s motion range is minimal, but within the acquisition time window of these two methods, the liver and diaphragm still move, and the motion artifacts remain the same. severe. Moreover, DWI data acquisition is mostly multiple acquisitions (multiple NEXs, number of excitations), and there must be incomplete movement between the NEXs in the volume, while the MRI scanner uses multiple NEXs when reconstructing images. The data are averaged and reconstructed, so the DWI image contains information about motion artifacts.
再以肝DCE为例。现有技术中,肝DCE采集时间通常持续数分钟,不能实现屏气扫描。由于DCE的时间分辨率要求在10秒内(通常5到8秒),而现有技术中的呼吸门控和呼吸导航技术不但存在运动伪影,还存在采集窗口过窄的问题。而现有技术中提到的平静呼吸方式,行斜冠状或矢状位扫描(为了包含膈肌,用于DCE数据处理的图像配准)。因此,在图像采集期间,肝脏一直处于运动状态。Take hepatic DCE again as an example. In the prior art, the acquisition time of liver DCE usually lasts several minutes, and breath-hold scanning cannot be realized. Since the time resolution of DCE is required to be within 10 seconds (usually 5 to 8 seconds), the respiratory gating and respiratory navigation technologies in the prior art not only have motion artifacts, but also have the problem that the acquisition window is too narrow. For the calm breathing method mentioned in the prior art, an oblique coronal or sagittal scan is performed (in order to include the diaphragm, it is used for image registration of DCE data processing). Therefore, the liver is constantly in motion during image acquisition.
综上所述,现有技术中的DWI和DCE采集技术均存在运动伪影,在影像形态学上导致图像模糊。而在处理DWI和DCE数据时,则会导致感兴趣区(Region of Interests,ROI)的参数值严重偏离真实值(相对于静止状态),更严重者不能计算相关参数。To sum up, both DWI and DCE acquisition technologies in the prior art have motion artifacts, which lead to image blurring in image morphology. When processing DWI and DCE data, the parameter values of the Region of Interests (ROI) will seriously deviate from the true value (relative to the static state), and the more serious cases cannot calculate the relevant parameters.
此外,现有技术中的一些伪影消除方法也难以满足实际需要。In addition, some artifact removal methods in the prior art are also difficult to meet actual needs.
现有技术中的运动伪影校正主要有两种方法,一个是回顾性图像配准法,一个是前瞻性运动矫正法。There are mainly two methods for motion artifact correction in the prior art, one is a retrospective image registration method, and the other is a prospective motion correction method.
对回顾性图像配准法,是使用专门的图像配准软件(如3D-slicer),根据某些解剖标志(如血管)、按照刚性或非刚性原理,将图像进行配准,校正各采集容积之间的运动,从而可以减少运动伪影对结果的影响的一种方法。但目前临床常用的方法是对已经重建的DWI和DCE图像(即核磁共振扫描机计算呈现出来的图像)进行配准。如前所述,用于计算DWI和DCE参数的图像本身就含有运动伪影信息,通过传统的图像配准方式只能校正不同采集容积之间的位置错误(inter-volume variation),而不能校正采集容积内的位置错误(intra-volume variation)。For the retrospective image registration method, special image registration software (such as 3D-slicer) is used to register the images according to certain anatomical landmarks (such as blood vessels) according to the principle of rigidity or non-rigidity, and correct each acquisition volume. A method to reduce the impact of motion artifacts on the results. However, the current commonly used clinical method is to register the reconstructed DWI and DCE images (that is, the images presented by the MRI scanner). As mentioned earlier, the images used to calculate DWI and DCE parameters themselves contain motion artifact information, and the traditional image registration method can only correct inter-volume variation between different acquisition volumes, but not Position error within the acquisition volume (intra-volume variation).
对前瞻性运动校正法,即采集数据时就校正运动。常规采集方法进行数据采集时,激发脉冲空间位置不变,如果有运动(连续运动,如自由呼吸、呼吸门控和呼吸导航;或非导航多次屏气法),在不同时刻,靶层面的中心位置不与射频激励中心位置重合,因此靶层面所受到的射频激励不完全一致,由此得到的回波信号强度也不尽相同。而DWI和DCE的参数均是根据信号推导计算得来,因此最终导致根据信号计算得到的各种参数值产生误差。通过上述的图像配准,即使完全匹配也不能避免信号不一致造成的这种误差,因此必然会影响到相应影像生物标志的精度。For the prospective motion correction method, the motion is corrected when the data is collected. During data acquisition by conventional acquisition methods, the spatial position of the excitation pulse remains unchanged. If there is movement (continuous movement, such as free breathing, breath gating, and breath navigation; or non-navigation multiple breath-hold methods), at different times, the center of the target layer The position does not coincide with the center position of the radio frequency excitation, so the radio frequency excitation received by the target layer is not completely consistent, and the resulting echo signal strength is also different. However, the parameters of DWI and DCE are derived and calculated based on the signal, which eventually leads to errors in various parameter values calculated based on the signal. Through the above-mentioned image registration, such errors caused by signal inconsistency cannot be avoided even if they are completely matched, so the accuracy of the corresponding image biomarkers will inevitably be affected.
由上可知,即便是采用了现有技术中提到的运动伪影校矫正方法,所获得的校正后的DCE和DWI图像的精度仍然有较大误差,不利于图像的精准呈现,具有较大弊端。It can be seen from the above that even if the motion artifact correction method mentioned in the prior art is adopted, the accuracy of the corrected DCE and DWI images obtained still has a large error, which is not conducive to the accurate presentation of the image and has a large disadvantages.
因此,现有技术中的核磁共振成像方法所得的图像存在着误差较大的技术问题,现有技术中的核磁共振成像系统所得的图像也存在着误差较大的技术问题。Therefore, the image obtained by the nuclear magnetic resonance imaging method in the prior art has a technical problem of large error, and the image obtained by the nuclear magnetic resonance imaging system in the prior art also has the technical problem of large error.
发明内容Contents of the invention
鉴于现有技术中的核磁共振成像方法所获得的图像存在着误差较大的技术问题,有必要提供一种所得图像误差较小的核磁共振成像方法。In view of the technical problem of relatively large errors in images obtained by nuclear magnetic resonance imaging methods in the prior art, it is necessary to provide a nuclear magnetic resonance imaging method with relatively small errors in obtained images.
同时,鉴于现有技术中核磁共振成像系统所获得的图像存在着误差较大的技术问题,也有必要提供一种所得图像误差较小的核磁共振成像系统。At the same time, in view of the technical problem of large errors in the images obtained by the nuclear magnetic resonance imaging system in the prior art, it is also necessary to provide a nuclear magnetic resonance imaging system with a small error in the obtained images.
本发明的具体技术方案如下:Concrete technical scheme of the present invention is as follows:
本发明提供一种核磁共振成像方法。该核磁共振成像方法包括步骤:通过导航模块检测是否满足预定的扫描条件;在符合扫描条件时,通过扫描模块对待成像区域进行扫描并采集数据;发出呼吸提醒信息,通过导航模块继续检测是否满足预定的扫描条件;依据该数据进行成像。The invention provides a nuclear magnetic resonance imaging method. The nuclear magnetic resonance imaging method includes the steps of: using the navigation module to detect whether the predetermined scanning condition is met; scanning conditions; imaging is performed based on this data.
在一个进一步优化的具体实施方式中,步骤通过导航模块继续检测是否满足预定的扫描条件包括:对导航条发射检测信号,获取该导航条的物理位置;计算相邻两次获取得到的该导航条的位移。In a further optimized specific implementation, the step of continuing to detect whether the predetermined scanning condition is met through the navigation module includes: transmitting a detection signal to the navigation bar to obtain the physical position of the navigation bar; calculating the navigation bar acquired twice adjacently displacement.
在一个进一步优化的具体实施方式中,该核磁共振成像方法还包括步骤:每隔50毫秒获取一次该导航条的物理位置;连续三次该导航条的位移小于1毫米时,该扫描模块对该带成像区域进行扫描并采集数据。In a further optimized specific implementation, the nuclear magnetic resonance imaging method further includes the step of: acquiring the physical position of the navigation bar every 50 milliseconds; when the displacement of the navigation bar is less than 1 mm for three consecutive times, the scanning module The imaging area is scanned and data is collected.
在一个进一步优化的具体实施方式中,步骤发出提醒信息包括步骤:该提醒信息包括第一提醒信息和该第二提醒信息;该扫描模块扫描该待成像区域并采集数据大于等于6秒时,发出该第一提醒信息;该第一提醒信息发出后大于等于1.5秒后,发出该第二提醒信息;该第一提醒信息和该第二提醒信息通过显示装置显示,该第一提醒信息用于提醒换气,该第二提醒信息用于提醒屏气。In a further optimized specific embodiment, the step of sending out a reminder message includes the steps: the reminder message includes the first reminder message and the second reminder message; when the scanning module scans the area to be imaged and collects data for more than or equal to 6 seconds, sends out The first reminder message; the second reminder message is issued after 1.5 seconds or more after the first reminder message is sent; the first reminder message and the second reminder message are displayed by a display device, and the first reminder message is used to remind To take a breath, the second reminder message is used to remind you to hold your breath.
在一个进一步优化的具体实施方式中,该核磁共振成像方法还包括:循环执行以下步骤:导航模块检测是否满足预定的扫描条件;在符合扫描条件时,通过扫描模块对待成像区域进行扫描并采集数据;发出提醒信息;依据该数据进行成像;或者循环执行步骤:通过导航模块检测是否满足预定的扫描条件;在符合扫描条件时,通过扫描模块对待成像区域进行扫描并采集数据;发出提醒信息。In a further optimized specific embodiment, the nuclear magnetic resonance imaging method also includes: performing the following steps cyclically: the navigation module detects whether the predetermined scanning conditions are met; when the scanning conditions are met, the scanning module scans the area to be imaged and collects data ; send a reminder message; perform imaging according to the data; or execute the steps in a loop: check whether the predetermined scanning condition is met through the navigation module; when the scanning condition is met, scan the area to be imaged and collect data through the scanning module;
本发明还提供一种核磁共振成像系统。该核磁共振成像系统包括:导航模块,用于检测是否满足预定的扫描条件;扫描模块,用于在符合扫描条件时对待成像区域进行扫描并采集数据;提醒模块,用于发出呼吸提醒信息;成像模块,用于依据该数据进行成像。The invention also provides a nuclear magnetic resonance imaging system. The nuclear magnetic resonance imaging system includes: a navigation module, which is used to detect whether the predetermined scanning conditions are met; a scanning module, which is used to scan the area to be imaged and collect data when the scanning conditions are met; a reminder module, which is used to issue breathing reminder information; imaging module for imaging based on the data.
在一个进一步优化的具体实施方式中,该导航模块包括:信号发射单元,用于对导航条发射检测信号;位置获取单元,用于获取该导航条的物理位置;位移计算单元,用于计算相邻两次获取得到的该导航条的位移。In a further optimized specific embodiment, the navigation module includes: a signal transmitting unit, used for transmitting a detection signal to the navigation bar; a position acquisition unit, used for acquiring the physical position of the navigation bar; a displacement calculation unit, used for calculating the relative The displacement of the navigation bar acquired twice.
在一个进一步优化的具体实施方式中,该位置获取单元还用于每隔50毫秒获取一次该导航条的物理位置;该导航模块还包括条件判断单元,该条件判断单元用于在该导航条的位移连续三次小于1毫米时通知该扫描模块对该带成像区域进行扫描并采集数据。In a further optimized specific implementation, the position acquisition unit is also used to acquire the physical position of the navigation bar every 50 milliseconds; the navigation module also includes a condition judgment unit, and the condition judgment unit is used for When the displacement is less than 1 mm for three consecutive times, the scanning module is notified to scan the imaging area of the belt and collect data.
在一个进一步优化的具体实施方式中,该提醒模块包括第一提醒信息单元和第二提醒信息单元;该第一提醒信息单元用于在该扫描模块扫描该待成像区域并采集数据大于等于6秒时发出该第一提醒信息;该第二信息提醒单元用于在该第一提醒信息发出后大于等于1.5秒后发出该第二提醒信息;该提醒模块还用于将该第一提醒信息和该第二提醒信息通过显示装置显示,该第一提醒信息用于提醒换气,该第二提醒信息用于提醒屏气。In a further optimized specific embodiment, the reminder module includes a first reminder information unit and a second reminder information unit; the first reminder information unit is used to scan the area to be imaged in the scanning module and collect data for greater than or equal to 6 seconds The first reminder message is issued at any time; the second information reminder unit is used to send the second reminder message after 1.5 seconds or more after the first reminder message is sent; the reminder module is also used to combine the first reminder message with the The second reminder information is displayed by the display device, the first reminder information is used to remind ventilation, and the second reminder information is used to remind breath-holding.
在一个进一步优化的具体实施方式中,该核磁共振成像系统还包括:循环执行模块,用于循环启动该导航模块、扫描模块、提醒模块和成像模块:或者,该循环执行模块用于循环启动该导航模块、扫描模块和提醒模块。In a further optimized specific embodiment, the nuclear magnetic resonance imaging system also includes: a cyclic execution module for cyclically starting the navigation module, scanning module, reminder module and imaging module; or, the cyclic execution module is used for cyclically starting the Navigation module, scanning module and reminder module.
相较于现有技术,本发明的主要有益效果在于:Compared with the prior art, the main beneficial effects of the present invention are:
由于本发明的核磁共振成像方法包括步骤:通过导航模块检测是否满足预定的扫描条件;在符合扫描条件时,通过扫描模块对待成像区域进行扫描并采集数据;发出呼吸提醒信息,通过导航模块继续检测是否满足预定的扫描条件;依据该数据进行成像;使得本发明的核磁共振成像方法能够使患者依据呼吸提示信息配合本发明进行检测,呼吸提示信息能够依据预设的规则提醒患者进行呼吸运动,使得扫描成像时能够有效规避因为呼吸运动带来的误差,从而使得本方法的成像精度较高。Because the nuclear magnetic resonance imaging method of the present invention includes the steps of: detecting whether the predetermined scanning condition is met through the navigation module; when the scanning condition is met, scanning the area to be imaged through the scanning module and collecting data; sending a breathing reminder message, and continuing to detect through the navigation module Whether the predetermined scanning conditions are met; imaging is performed according to the data; the magnetic resonance imaging method of the present invention can enable the patient to cooperate with the present invention for detection according to the breathing prompt information, and the breathing prompt information can remind the patient to perform breathing exercises according to preset rules, so that During scanning and imaging, the error caused by respiratory movement can be effectively avoided, so that the imaging accuracy of the method is relatively high.
由于本发明的该核磁共振成像系统包括:导航模块,用于检测是否满足预定的扫描条件;扫描模块,用于在符合扫描条件时对待成像区域进行扫描并采集数据;提醒模块,用于发出呼吸提醒信息;成像模块,用于依据该数据进行成像;使得本发明的核磁共振成像方法能够使患者依据呼吸提示信息配合本发明进行检测,呼吸提示信息能够依据预设的规则提醒患者进行呼吸运动,使得扫描成像时能够有效规避因为呼吸运动带来的误差,从而使得本方法的成像精度较高。Because the nuclear magnetic resonance imaging system of the present invention includes: a navigation module, used to detect whether a predetermined scan condition is met; a scan module, used to scan and collect data in the area to be imaged when the scan condition is met; a reminder module, used to issue a breath Reminder information; imaging module, used for imaging according to the data; enabling the MRI method of the present invention to enable the patient to cooperate with the present invention for detection according to the breathing prompt information, and the breathing prompt information can remind the patient to perform respiratory exercise according to preset rules, This makes it possible to effectively avoid errors caused by respiratory movement during scanning and imaging, thus making the imaging accuracy of the method higher.
附图说明Description of drawings
图1是本发明核磁共振成像方法的一个优选实施方式的流程示意图;Fig. 1 is a schematic flow sheet of a preferred embodiment of the nuclear magnetic resonance imaging method of the present invention;
图2是本发明核磁共振成像系统的一个优选实施方式的模块示意图。Fig. 2 is a block diagram of a preferred embodiment of the nuclear magnetic resonance imaging system of the present invention.
具体实施方式Detailed ways
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合附图及实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用来限定本发明。In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
请参阅图1和图2,图1是本发明核磁共振成像方法的一个优选实施方式的流程示意图;图2是本发明核磁共振成像系统的一个优选实施方式的模块示意图。Please refer to Fig. 1 and Fig. 2, Fig. 1 is a schematic flow chart of a preferred embodiment of the nuclear magnetic resonance imaging method of the present invention; Fig. 2 is a schematic block diagram of a preferred embodiment of the magnetic resonance imaging system of the present invention.
本发明的核磁共振成像系统2包括一个导航模块21、一个扫描模块22、一个提醒模块23和一个成像模块24。该导航模块用于检测是否满足预定的扫描条件;该扫描模块22用于在符合扫描条件时对待成像区域进行扫描并采集数据;该提醒模块23,用于发出呼吸提醒信息;该成像模块24,用于依据该数据进行成像。The magnetic
导航序列是基于自旋回波(spin echo)工作。在使用两个方向的选层梯度事,只有这两个方向的层面交叉处的自旋才会重聚并产生回波信号,这条交叉处的窄带通常称作导航条(navigator)。当该导航条被设置在膈肌上的时候,就可以用来跟踪膈肌的运动。膈肌上产生的导航信号经过RT-Hawk(Reference:Santos JM,Wright GA,Pauly JM.Flexible real-time magnetic resonance imagingframework.Conf Proc IEEE Eng Med Biol Soc2004;2:1048-1051)传送到外接电脑,经过实时处理之后可以得到膈肌的相对位移。该相对位移会被立刻反馈到核磁共振成像的控制计算机系统,并在50ms内调整扫描参数,以实现运动实时跟踪与校正。The navigation sequence is based on spin echo (spin echo) work. When using layer selection gradients in two directions, only the spins at the intersection of the two directions will reunite and generate echo signals. This narrow band at the intersection is usually called a navigator. When the navigation bar is set on the diaphragm, it can be used to track the movement of the diaphragm. The navigation signal generated on the diaphragm is transmitted to the external computer through RT-Hawk (Reference: Santos JM, Wright GA, Pauly JM. Flexible real-time magnetic resonance imaging framework. Conf Proc IEEE Eng Med Biol Soc2004; 2:1048-1051), and after The relative displacement of the diaphragm can be obtained after real-time processing. The relative displacement will be immediately fed back to the MRI control computer system, and the scanning parameters will be adjusted within 50ms to achieve real-time tracking and correction of motion.
该导航模块21即包括用于发射和检测信号的检测装置,以及将检测信号折算成导航条相对位移的计算机系统。具体的,该导航模块包括:信号发射单元,用于对导航条发射检测信号;位置获取单元,用于获取该导航条的物理位置;位移计算单元,用于计算相邻两次获取得到的该导航条的位移。The navigation module 21 includes a detection device for transmitting and detecting signals, and a computer system for converting the detection signals into relative displacements of the navigation bar. Specifically, the navigation module includes: a signal transmitting unit, configured to transmit a detection signal to the navigation bar; a position acquisition unit, configured to acquire the physical position of the navigation bar; a displacement calculation unit, configured to calculate the The displacement of the navigation bar.
该扫描模块22可以是通常的DWI序列扫描或者DCE序列扫描。The
该提醒模块23通常为一个显示装置。该提醒模块23可以用来显示换气信息或者屏气信息。换气信息是用于告诉患者应该呼吸换气,屏气信息用于告诉患者应该屏住呼吸。在另外也给实施方式中,该提醒模块23还可以包括一个声音装置。在用文字或者图像显示换气信息后者屏气信息的同时,还可以发出提醒声音,避免患者疏漏。The
该成像模块24接受该扫描模块22传来的数据信息,并将该等数据依据预先设置的参数等转化为可视的医学影像。The
本发明核磁共振成像方法包括步骤:The nuclear magnetic resonance imaging method of the present invention comprises steps:
S11、通过导航模块检测是否满足预定的扫描条件;S11. Detecting whether a predetermined scanning condition is met through the navigation module;
首先,通过信号发射单元对导航条发射检测信号。导航条通过产生回波信号被该位置获取单元获取,并通过该回波信号计算出该导航条的物理位置。该位移计算单元根据时间记录每个采样时的导航条的物理位置,并计算相邻两次导航条的位移。即,位移为当前时刻导航条的物理位置与上一次采样时刻导航条的物理位置的差值的绝对值。First, a detection signal is transmitted to the navigation bar through the signal transmitting unit. The navigation bar is acquired by the position obtaining unit by generating an echo signal, and the physical position of the navigation bar is calculated through the echo signal. The displacement calculation unit records the physical position of the navigation bar at each sampling time according to time, and calculates the displacement of two adjacent navigation bars. That is, the displacement is the absolute value of the difference between the physical position of the navigation bar at the current time and the physical position of the navigation bar at the last sampling time.
通常情况下,每相隔50毫秒,该信号发射单元、该位置获取单元以及该位移计算单元便执行上述的工作步骤,以实施获取导航条的位置及位移。Normally, at intervals of 50 milliseconds, the signal transmitting unit, the position obtaining unit and the displacement calculating unit execute the above-mentioned working steps to obtain the position and displacement of the navigation bar.
在本发明核磁共振成像方法的优选实施方式中,该预定的扫描条件为:连续三次该导航条的位移小于1毫米。在另外一个实施方式中,该预定的扫描条件也可以为连续四次、五次或者更多次该导航条的位移小于1毫米、2毫米或者0.8毫米等。具体的预设的扫描条件还可以根据实际情况进行调整,该预设的扫描条件主要是为了确定待成像区域暂停运动或者基本暂停运动。只要能确定该待成像区域已经暂停运动或者基本暂停运动的条件,都可以设定为该预定的扫描条件。In a preferred embodiment of the magnetic resonance imaging method of the present invention, the predetermined scanning condition is: the displacement of the navigation bar is less than 1 mm for three consecutive times. In another embodiment, the predetermined scanning condition may also be that the displacement of the navigation bar is less than 1 mm, 2 mm or 0.8 mm for four, five or more consecutive times. The specific preset scanning conditions can also be adjusted according to the actual situation, and the preset scanning conditions are mainly for determining that the region to be imaged is suspended or basically suspended. As long as it can be determined that the region to be imaged has suspended movement or has basically suspended movement, it can be set as the predetermined scanning condition.
S12、在符合扫描条件时,通过扫描模块对待成像区域进行扫描并采集数据;S12. When the scanning conditions are met, scan the area to be imaged through the scanning module and collect data;
在连续三次该导航条的位移小于1毫米时,启动该扫描单元对待成像区域进行扫描,从而获得相应数据。When the displacement of the navigation bar is less than 1 mm for three consecutive times, the scanning unit is activated to scan the area to be imaged, so as to obtain corresponding data.
通常为了能够清晰的获得成像数据,在本发明核磁共振成像方法的优选实施方式中,该扫描模块对该待成像区域的扫描时间预设为6秒。在另外一个实施方式中,该预设的扫描时间也可以为6秒以上。具体的预设时间的长短,可以根据患者换气屏气的能力而定。例如,一个人肺活量较小,屏气时间较短,则可以将该预设的扫描时间定位6秒;如果一个人肺活量较大,屏气能力较长,屏气时间较长,每次屏气时间都能超过10秒,那么可以将该预定时间定位6至10秒中的任意一个数值。Usually, in order to obtain imaging data clearly, in a preferred embodiment of the magnetic resonance imaging method of the present invention, the scanning time of the scanning module for the area to be imaged is preset at 6 seconds. In another embodiment, the preset scanning time may also be more than 6 seconds. The length of the specific preset time can be determined according to the ability of the patient to take breath and hold the breath. For example, if a person has a small lung capacity and a short breath-hold time, the preset scan time can be set at 6 seconds; 10 seconds, then the predetermined time can be set at any value from 6 to 10 seconds.
该扫描模块22采集获得用于成像的数据后,将该数据传递给该成像单元24,该该成像单元24依据该等数据进行成像,形成可以供医生参考的医学影像。After the
该扫描模块22可以通过启动DCE-3D SPGR(三维饶相梯度回波序列,3dimensional spoiled gradient-recalled acquisition,3D-SPGR)或者DWI-EPI(扩散加权平面回波成像,echo planar imaging diffusion-weighted magnetic resonanceimaging,EPI-DWI)序列对待成像区域进行扫描。在扫描时,本发明核磁共振成像系统2的扫描参数,包括射频发射和接收频率已经相位信息(RF transmitand receive frequencies and phases)相对于步骤S11中的数值均需要调整。The
S13、发出呼吸提醒信息,并通过导航模块继续检测是否满足预定的扫描条件;S13. Send a breathing reminder message, and continue to detect whether the predetermined scanning condition is met through the navigation module;
该提醒信息包括第一提醒信息和该第二提醒信息;该扫描模块扫描该待成像区域并采集数据大于等于6秒时,发出该第一提醒信息;该第一提醒信息发出后大于等于1.5秒后,发出该第二提醒信息;该第一提醒信息和该第二提醒信息通过显示装置显示,该第一提醒信息用于提醒换气,该第二提醒信息用于提醒屏气。The reminder information includes the first reminder information and the second reminder information; when the scanning module scans the area to be imaged and collects data for more than or equal to 6 seconds, it sends the first reminder information; after the first reminder information is sent, it is greater than or equal to 1.5 seconds Afterwards, the second reminder message is issued; the first reminder message and the second reminder message are displayed by the display device, the first reminder message is used to remind breath taking, and the second reminder message is used to remind breath-holding information.
具体地,该第一提醒信息可以是“请换气,换气时间为1.5秒”;该第二提醒信息可以是“请屏气,屏气时间请超过6秒”。同时,该提醒模块23上还可以包括一个计时单元,该计时单元可以通过倒计时的方法提醒患者距离换气还有多长时间。如前所述,当步骤S12中的扫描时间为7秒、8秒或者9秒时,该等提醒屏气的时间就分为为7秒、8秒或者9秒。Specifically, the first reminder message may be "please take a breath, and the time for breathing is 1.5 seconds"; the second reminder message may be "please hold your breath, please hold your breath for more than 6 seconds". At the same time, the reminding
当然,人换气的时间也是可以预先设置的,具体以患者本身情况而定。Of course, the time for a person to take a breath can also be preset, depending on the patient's own situation.
在另外一个实施方式中,在步骤S12执行完之后,提醒换气的同时执行步骤S11,即,步骤S11和步骤S12交替执行。提醒换气的步骤与步骤S11可以同时执行,也就是步骤S13包括提醒换气和步骤S11。本处是为了便于描述,在不同的实施方式中,也可以将提醒换气和步骤S11分开描述。In another embodiment, after step S12 is executed, step S11 is executed at the same time as prompting for ventilation, that is, step S11 and step S12 are alternately executed. The step of reminding ventilation and step S11 can be executed simultaneously, that is, step S13 includes reminding ventilation and step S11. Here, for the convenience of description, in different implementation manners, the prompting for ventilation and step S11 may also be described separately.
S14、依据该数据进行成像。S14. Perform imaging according to the data.
在步骤S12执行完毕时,可以通过成像模块24对扫描模块22采集的数据进行处理,将该数据转换为医学影像。通常的,对于不同的实际应用中,每次一扫描所获得的数据只能形成一个完整医学影像的一个子部分。也就是说,通常一个身体内部器官的扫描需要扫描多次才能完成,每一次扫描仅仅是针对该内部器官的一个局部。因此,在另外一个实施方式中,如需要对整个器官或者对一个较大的区域进行医学成像,同时鉴于每次扫描只能扫描一个小区域,则本发明核磁共振成像方法需要进行多次扫描。具体的,是将一个较大的区域分割为数个或者数十个小区域,每屏气一次扫描其中一个区域,屏气多次完成该多个小区域的扫描,将该多个小区域扫描的数据汇总至成像模块,该成像模块依据该多个数据进行处理,最终获得所需要的医学影像。After step S12 is executed, the
综上所述,本发明核磁共振成像方法和系统通过采用间歇式的换气与屏气的方法,通过对患者进行换气和屏气的引导,通过线性导航序列检测屏气后膈肌的位移,在患者屏气且其膈肌基本无运动时对患者进行扫描获取数据,每次扫描后提示患者进行换气与屏气,之后再进行下一次扫描;最终通过扫描所得的数据进行成像。因此,相对于现有技术,本发明核磁共振成像方法和系统能够有效的消除因为呼吸引起的内部器官运动而导致的伪影问题,从而使得最终获得医学影像的精度较高。In summary, the MRI method and system of the present invention adopt intermittent ventilation and breath-holding methods, guide the patient to perform ventilation and breath-holding, and detect the displacement of the diaphragm after breath-holding through a linear navigation sequence. And the patient is scanned to obtain data when the diaphragm is basically inactive. After each scan, the patient is prompted to ventilate and hold the breath, and then the next scan is performed; finally, imaging is performed based on the scanned data. Therefore, compared with the prior art, the magnetic resonance imaging method and system of the present invention can effectively eliminate the artifact problem caused by internal organ movement caused by respiration, so that the accuracy of the finally obtained medical image is higher.
本领域内的技术人员应明白,本发明的实施例可提供为方法、系统,也可为计算机程序产品。在为计算机程序产品时,通过加载能够体现本发明的方法的计算机程序,能够调动核磁共振成像设备按照本发明的方法进行运行,从而实现本发明所描述的各种目的,解决相应的技术问题,实现技术效果。Those skilled in the art should understand that the embodiments of the present invention may be provided as methods, systems, or computer program products. When it is a computer program product, by loading a computer program that can embody the method of the present invention, the nuclear magnetic resonance imaging equipment can be mobilized to operate according to the method of the present invention, thereby achieving various purposes described in the present invention and solving corresponding technical problems. achieve technical results.
因此,本发明可采用完全硬件实施例、完全软件实施例、或结合软件和硬件方面的实施例的形式。而且,本发明可采用在一个或多个其中包含有计算机可用程序代码的计算机可用存储介质(包括但不限于磁盘存储器、CD-ROM、光学存储器等)上实施的计算机程序产品的形式。Accordingly, the present invention can take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present invention may take the form of a computer program product embodied on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) having computer-usable program code embodied therein.
本发明是参照根据本发明实施例的方法、终端(系统)、和计算机程序产品的流程图和/或方框图来描述的。应理解可由计算机程序指令实现流程图和/或方框图中的每一流程和/或方框、以及流程图和/或方框图中的流程和/或方框的结合。可提供这些计算机程序指令到通用计算机、专用计算机、嵌入式处理机或其他可编程数据处理设备的处理器以产生一个机器,使得通过计算机或其他可编程数据处理设备的处理器执行的指令产生用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的装置。The present invention is described with reference to flowchart illustrations and/or block diagrams of methods, terminals (systems), and computer program products according to embodiments of the invention. It should be understood that each procedure and/or block in the flowchart and/or block diagram, and combinations of procedures and/or blocks in the flowchart and/or block diagram can be realized by computer program instructions. These computer program instructions may be provided to a general purpose computer, special purpose computer, embedded processor, or processor of other programmable data processing equipment to produce a machine such that the instructions executed by the processor of the computer or other programmable data processing equipment produce a Means for realizing the functions specified in one or more steps of the flowchart and/or one or more blocks of the block diagram.
这些计算机程序指令也可存储在能引导计算机或其他可编程数据处理设备以特定方式工作的计算机可读存储器中,使得存储在该计算机可读存储器中的指令产生包括指令装置的制造品,该指令装置实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能。These computer program instructions may also be stored in a computer-readable memory capable of directing a computer or other programmable data processing apparatus to operate in a specific manner, such that the instructions stored in the computer-readable memory produce an article of manufacture comprising instruction means, the instructions The device realizes the function specified in one or more procedures of the flowchart and/or one or more blocks of the block diagram.
这些计算机程序指令也可装载到计算机或其他可编程数据处理设备上,使得在计算机或其他可编程设备上执行一系列操作步骤以产生计算机实现的处理,从而在计算机或其他可编程设备上执行的指令提供用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的步骤。These computer program instructions can also be loaded onto a computer or other programmable data processing device, causing a series of operational steps to be performed on the computer or other programmable device to produce a computer-implemented process, thereby The instructions provide steps for implementing the functions specified in the flow chart flow or flows and/or block diagram block or blocks.
应说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的精神和范围,其均应涵盖在本发明的权利要求范围当中。It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention without limitation, although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be carried out Modifications or equivalent replacements without departing from the spirit and scope of the technical solution of the present invention shall be covered by the claims of the present invention.
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