CN103263453A - Traditional Chinese medicine preparation for treatment of hyperlipidemia, hyperglycemia, high blood viscosity and hypertension and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treatment of hyperlipidemia, hyperglycemia, high blood viscosity and hypertension and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a traditional Chinese medicine preparation for treatment of hyperlipidemia, hyperglycemia, high blood viscosity and hypertension and a preparation method thereof. The traditional Chinese medicine preparation is characterized in that the preparation method includes grounding dry pseudo-ginseng and dry leeches into powders, weighing two powders as a formula, mixing uniformly to obtain a powder, filling the powder into capsules to get capsules, adding a molding agent in the amount required for molding to mix, and pressing to get granules, tablets or pills. The traditional Chinese medicine preparation is simple in formula, significant in efficacy, without toxic and side effects, safe and reliable, can make blood lipid, blood viscosity, blood glucose and blood pressure to return to normal in a short time by a medicine, helps to reduce the trouble and pain for patients to take medicine, is simple in process, easy to make and low in cost, helps to reduce the financial burden of patients, is a good medicine for hyperlipidemia, hyperglycemia, high blood viscosity, hypertension and other cardiovascular diseases, and is suitable for pharmaceutical production factories and patients to use.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, more particularly, the present invention relates to a kind of hyperlipidemia, hyperglycemia, high blood viscosity and hypertensive Chinese medicine preparation and preparation method thereof for the treatment of.
Background technology
Hyperlipidemia, hyperglycemia, high blood viscosity and hypertension (hereinafter to be referred as " four height ") are comparatively ubiquitous diseases in the mid-aged population, along with growth in the living standard and the hysteresis that prevents and treats method, preventive treatment knowledge, in recent years, the trend that in young and middle-aged crowd, spreads in addition of " four height " patient." four height " disease is that " affluenza " derived from modern society, and possible individualism also may be interrelated.As: the diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference is aggravated hypertension, so the later stage has all formed " four height " disease.At present, in the Chinese ten big causes of death, the mortality rate relevant with metabolic disease is up to 35.7%, and the death toll relevant with " four height " also accounts for 27% of total death toll.The blood vessel embolism that hyperlipidemia can cause; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.World Health Organization (WHO) once spelt out, and prevented that the first line of defence of cardiovascular disease from reducing exactly " four height " and control " four height ".
At present, prevention and the control method of " four height " disease have a lot.Can prevent by aerobatic exercise, reasonable diet control, smoking cessation, sobriety, joint sugar, the psychological mood of adjusting; Help that can be by the doctor and take fat-reducing, less salt, low fat, low sugar medicated diet and Chinese and western drugs to cure " four height ".But it is expensive that these medicines have, have repeatedly after the healing that has, and have basic just what not to play big, the administration time that has is long, the medicine that has simply just can only be controlled a kind of disease, helpless at all to appearing at same patient various disease conditions on one's body, cure same patient various disease conditions on one's body, just must use multiple medicine.Therefore, the patient who has is owing to suffer from various disease conditions, thereby must carry on the back several on one's body even tens kinds of medicines, become genuine " sickly person ".Up to the present, also there is not short, the evident in efficacy medicine appearance of a kind of Drug therapy various disease conditions and treatment time.
Summary of the invention
The objective of the invention is to overcome the deficiency of existing " four height " Drug therapy technology, provide a kind of and can treat short, evident in efficacy Chinese medicine preparation of various disease conditions and treatment time and preparation method thereof simultaneously.
Purpose of the present invention is achieved by following technical proposals.
Chinese medicine preparation prescription of the present invention (percentage by weight) is: Radix Notoginseng (doing) 30%～50%, Hirudo (doing) 50%～70%.
The preparation method of Chinese medicine preparation of the present invention is: with Radix Notoginseng (doing), Hirudo (doing) pulverizing respectively, then by the prescription weighing mix powder; With powder pack in the capsule for medicine capsule; In powder, add the forming agent of molding aequum and mix suppress granule or tablet or pill.
The invention has the beneficial effects as follows:
1, Chinese medicine preparation of the present invention is made up of Radix Notoginseng (doing), two kinds of Chinese crude drugs of Hirudo (doing).
Radix Notoginseng: its function is hemostasis, the blood that looses, and analgesic therapy cures mainly to fall and pounces on congestive edema, thoracic obstruction angor, lump in the abdomen, blood stasis amenorrhea, dysmenorrhea, the cloudy stomachache of the stasis of blood in puerperal, sore, carbuncle and painful swelling.The modern Chinese medicine pharmacological research confirms that Radix Notoginseng has hemostasis, and antithrombotic promotes hemopoietic, and to the effect of cardiovascular system, antiinflammatory protects the liver, antitumor, and the analgesic pharmacological effect has good hemostasia effect and significant hemopoietic function.With the hemostasis of Radix Notoginseng dissipating blood stasis, the pharmacological action that subduing swelling and relieving pain is relevant is very extensive, comprises hemostasis, and antithrombotic promotes hemopoietic, expand blood vessel, blood pressure lowering resists myocardial ischemia, anti-cerebral ischemia, arrhythmia, atherosclerosis, antiinflammatory protects the liver, antitumor, effects such as analgesia.Main effective ingredient is: Radix Notoginseng total arasaponins (PNS), Radix Notoginseng panaxatriol glycoside (PTS), Radix Notoginseng panoxadiol glycoside (PDS) and Radix Notoginseng propylhomoserin.Normal food Radix Notoginseng, expansible coronary artery.Improve blood supply of cardiac muscle, increase blood vessel elasticity, cardiovascular disease is had significant control and preventive and therapeutic effect.
Hirudo: be commonly called as Hirudo, contain hirudin, can delay and hinder blood coagulation, thereby blood coagulation resisting function is arranged, its dry products is concocted the back traditional Chinese medical science and is used as medicine, and has the effect for the treatment of apoplexy, hypertension, the clear stasis of blood, amenorrhea, traumatic injury.The modern Chinese medicine pharmacological research confirms that Hirudo has effects such as anticoagulation, anti-various thrombosis, blood fat reducing, anti-cephalophyma and ecchymosis, has found also that in recent years the Hirudo preparation has specially good effect at control cardiovascular and cerebrovascular disease and anticancer aspect.
Radix Notoginseng and Hirudo are used as medicine jointly, can eliminate high blood viscosity, hyperlipidemia effectively, and high blood viscosity, hyperlipidemia are to cause thrombosis and then cause hypertensive major reason, simultaneously, hyperglycemia has very big related with hyperlipidemia, thereby, eliminated hyperlipidemia and high blood viscosity and just eliminated hypertension and hyperglycemia, and Radix Notoginseng and Hirudo there are the effect of antithrombotic, expansion blood vessel, blood fat reducing, be used as medicine simultaneously, can complement one another, increase effect and effect, thereby reach the purpose of elimination " four height ".
2, the present invention is evident in efficacy, and short treating period, curative effect are reliable.Its model case is as follows:
Case 1: patient, yellow * *, the man took medicine 63 years old then, laboratory test report shows before taking medicine: blood high viscosity syndrome, the inclined to one side piece of erythrocyte sedimentation rate, Fibrinogen is bigger than normal, blood coagulation increases, erythrocyte aggregation increases, 19 laboratory indexes have only one normally, other 18 severe overweights.After seeking medical advice, by every day three times, each 1 gram is obeyed Chinese medicine preparation of the present invention after 30 days continuously, and 10 transfer to normally in 19 laboratory indexes, and other indexs obviously reduce, after continued to take medicine 20 days, every index all transfers to normally.
Case 2: the patient, Wu * *, 59 years old, eyes distending pain, twinge before taking medicine, the blood thickness is more serious, and the blood fat laboratory indexes is in normal range, after taking medicine 40 days, blood thickness problem solves, blood fat chemical examination T-CHOL 7.6mmoI/L, triglyceride 2.15mmoI/L, eyes swell and ache, twinge alleviates, and take medicine 20 days again, and eyes distending pain, twinge phenomenon are eliminated, blood fat check triglyceride 1.40mmoI/L, T-CHOL 6.43mmoI/L.
Case 3: the patient, Lee * *, the man, 57 years old, before taking medicine, the sticking indexs of 15 blood have 9 normal, 6 exceed standard, after taking medicine 50 days 15 sticking indexs of blood have 12 normal, 4 exceed standard, drug withdrawal is checked after half a year, 15 sticking indexs of blood are all normal.
Case 4: the patient, Zhao * *, the man, 50 years old, once suffered from transient apoplexy, laboratory test report is shown as blood high viscosity syndrome before taking medicine, and multinomial laboratory indexes obviously exceeds standard, and checks after taking medicine 30 days that every index all reaches normal value.
Case 5: the patient, Wu * *, woman, 52 years old, laboratory test report shows T-CHOL 9.62mmoI/L before taking medicine, and triglyceride 9.95mmoI/L belongs to the mixed type hyperlipidemia, checks after taking medicine 20 days, T-CHOL 7.02mmoI/L, glyceride 3.59mmoI/L, two indexs descend obviously, and are evident in efficacy.
Case 6: the patient, yellow * *, the man, 35 years old, suffer from hyperlipidemia, once suffered from transient apoplexy, triglyceride 7.38mmoI/L before taking medicine after taking medicine 30 days, is down to 2.31mmoI/L, and effect is remarkable.
Case 7: patient, Lee * *, woman, 50 years old, laboratory test report is shown as T-CHOL type hyperlipidemia, obvious headache and dizzy symptom is arranged before the patient takes medicine, and symptom is eliminated fully after taking medicine 40 days, and result of laboratory test also is down to 6.52mmoI/L from original 9.56mmoI/L, according to its reflection, symptom progressively alleviates after taking medicine 20 days, and like one day, left and right sides headache and dizzy symptom was eliminated fully in 30 days with one day after.
Case 8: the patient, complete * *, the woman, 60 years old, T-CHOL type hyperlipidemia, after taking medicine 20 days, T-CHOL is down to 7.12mmoI/L from 9.61mmoI/L.
Case 9: the patient, multitude * *, the man, 65 years old, triglyceride type hyperlipidemia had dizzy phenomenon before taking medicine, and after taking medicine 20 days, triglyceride is down to 2.82mmoI/L from 6.93mmoI/L, and symptom is eliminated.
Case 10: the patient, recklessly * *, man, 62 years old, laboratory test report is shown as typical high blood viscosity, hyperlipidemia, hyperglycemic patients, and transient apoplexy twice once then is after taking medicine 40 days, check high blood viscosity, hyperglycemia are eliminated fully, and hyperlipidemia is near normal range, and hypertension also takes an evident turn for the better.
Case 11: patient, the river * *, woman, 68 years old, apoplexy sequela patient in 2003, right hemiplegia of limb, after taking medicine 20 days in 2007, triglyceride is down to 5.05mmoI/L from 13.45mmoI/L, took medicine again 40 days, right crus of diaphragm is drawn the circle phenomenon and is disappeared, and can manage cook, housework such as cooking, recovered self-care ability fully.
Case 12: the patient, stone * *, man, 61 years old, apoplectic hemiplegia patient in 2009, left side limbs can not be puted forth effort, and can only rely on the wheelchair life, after taking medicine 50 days in November, 2010, and the left hand restore funcitons, spent 5 days again, left foot can land, and can take a step to walk by crutch, and curative effect is obvious.
The principle that Chinese medicine preparation of the present invention can be treated " four height " disease is:
1. most of hyperglycemic patients have in tangible hyperlipidemia or the blood vessel and have fatty spew; the back hyperlipidemia of taking medicine eliminates or fatty spew dissolves; and hyperlipidemia or fatty spew are to hinder the basic reason that insulin discharges; as long as patient's pancreas insulin function is not lost; blood fat is eliminated after obeying Chinese medicine preparation of the present invention; insulin can normally discharge, and blood glucose will recover normal or lower.
2. after the fatty spew in the blood vessel was eliminated, blood circulation hinders to be eliminated, and blood is sticking, blood pressure will be got back to normal condition.
3, Chinese medicine preparation of the present invention has no side effect, and is safe and reliable.
Chinese medicine preparation of the present invention entrusts Guangxi Municipality Institute of Traditional Chinese Medicine's pharmacology to carry out 7 days acute toxicity test by a definite date in July, 2011.(promulgate in March, 2005 at State Food and Drug Administration drug approval center by " Chinese medicine, natural drug studies on acute toxicity technological guidance principle " in this institute, number [Z] GDT2-1) and " herbal pharmacology research methodology " (People's Health Publisher's second edition, requirement 2006:107-108), with Chinese medicine preparation of the present invention and kunming mice (SPF level, male and female half and half, provided the quality certification number by Guangxi Medical University's Experimental Animal Center: SCXK osmanthus 2009-0002) carried out the acute toxicity test of gastric infusion secondary in the mice one day.Its conclusion is: the maximum dosage-feeding of gastric infusion secondary is 16.2g medicated powder/Kg in the Chinese medicine preparation mice of the present invention a day, be equivalent to clinical plan with daily dose (270 times of 3.6g medicated powder/day/60kg), tangible poisoning manifestations and death condition do not appear in animal after the administration, and its general body state, behavioral activity, feed situation administration front and back are no abnormal and difference all.
4, Chinese medicine preparation prescription of the present invention is simple, makes easily, and cost is low, but effect is remarkable, can benefit vast " four height " disease patient and cardiovascular patient.
The specific embodiment
According to clinical practice the specific embodiment of the present invention is further described below:
Embodiment 1: respectively with Radix Notoginseng (doing), Hirudo (doing) pulverizing, take by weighing 30% Radix Notoginseng (doing) powder and 70% Hirudo (doing) powder then by weight percentage, place the container for stirring mix homogeneously, get powder.Take according to quantity then or directly, or fill becomes capsule, or in powder, add the forming agent of molding aequum and mix after be pressed into granule, tablet or pill.
Embodiment 2: take by weighing 50% Radix Notoginseng (doing) powder and 50% Hirudo (doing) powder by weight percentage, all the other are with embodiment 1.
Embodiment 3: take by weighing 45% Radix Notoginseng (doing) powder and 55% Hirudo (doing) powder by weight percentage, all the other are with embodiment 1.
Claims (2)
1. hypertensive Chinese medicine preparation for the treatment of hyperlipemia and hyperglycemia high blood viscosity and preparation method thereof comprises prescription and preparation method, it is characterized in that the prescription of this Chinese medicine preparation (percentage by weight) is: Radix Notoginseng (doing) 30%-50%, Hirudo (doing) 50%-70%.
2. hypertensive Chinese medicine preparation for the treatment of hyperlipemia and hyperglycemia high blood viscosity according to claim 1 and preparation method thereof is characterized in that described preparation method is:
With Radix Notoginseng (doing), Hirudo (doing) pulverizing respectively, then by the prescription weighing mix powder; With powder pack in the capsule for medicine capsule; In powder, add the forming agent of molding aequum and mix suppress granule or tablet or pill.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679725A (en) * | 2005-01-25 | 2005-10-12 | 王维和 | Medicinal preparation of oral dropps with blood-activating Chinese medicine notogiseng and leech extract preparation |
| CN1679639A (en) * | 2005-01-25 | 2005-10-12 | 王维和 | Oral soft capsule of medicinal preparation from blood-activating Chinese medicine pseudo-ginseng and leech extract |
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- 2013-03-14 CN CN2013100829119A patent/CN103263453A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679725A (en) * | 2005-01-25 | 2005-10-12 | 王维和 | Medicinal preparation of oral dropps with blood-activating Chinese medicine notogiseng and leech extract preparation |
| CN1679639A (en) * | 2005-01-25 | 2005-10-12 | 王维和 | Oral soft capsule of medicinal preparation from blood-activating Chinese medicine pseudo-ginseng and leech extract |
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Application publication date: 20130828 |