CN103263389A - Cefoxitin sodium freeze-dried powder injection for injection and preparation method thereof - Google Patents
Cefoxitin sodium freeze-dried powder injection for injection and preparation method thereof Download PDFInfo
- Publication number
- CN103263389A CN103263389A CN2013102065472A CN201310206547A CN103263389A CN 103263389 A CN103263389 A CN 103263389A CN 2013102065472 A CN2013102065472 A CN 2013102065472A CN 201310206547 A CN201310206547 A CN 201310206547A CN 103263389 A CN103263389 A CN 103263389A
- Authority
- CN
- China
- Prior art keywords
- medicinal liquid
- injection
- cefoxitin sodium
- cefoxitin
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a cefoxitin sodium freeze-dried powder injection for injection, and a preparation method of the injection. The injection is prepared by freeze-drying a medicine liquid containing cefoxitin sodium; and the pH of the medicine liquid is conditioned to be 6.0 to 7.0 by using histidine. The freeze-dried powder injection disclosed by the invention is high in security and good in stability.
Description
Technical field
The invention belongs to medical technical field, in particular to a kind of cefoxitin for inj lyophilized injectable powder prescription and preparation technology thereof.
Background technology
The cefoxitin sodium for injection main component is cefoxitin sodium, chemical name is: methyl (6R, 7S)-3-[(1-carbamyl oxygen)]-7-methoxyl group-8-oxo-7-[2-(2-thienyl) acetylamino]-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-formic acid sodium salt, its structural formula is as follows:
Cefoxitin sodium is in the following infection due to clinical Your Majesty is mainly used in sensitive organism: go up lower respiratory infection, urinary tract infection comprises infection, septicemia (comprising typhoid fever), gynecological infection, bone, soft tissue of joint infection, endocarditis etc. in uncomplicated gonorrhea, peritonitis and other intraperitoneal, the pelvic cavity.Because this product effectively and to beta-lactamase is stablized anaerobe, so particularly suitable is aerobic and anaerobism mixed infection, and for the infection that this product sensitive bacterial is caused by producing beta-lactamase.
CN200910005009.0 discloses a kind of cefoxitin sodium powder-needle preparation for injection and preparation method thereof;
CN102895182A is by the appropriate design of technology, and some parameter control in the technology, can control the pH value scope of cefoxitin sodium for injection of preparation between 6.7-7.0, and every index meets the requirements.Yet above-mentioned patent technology all needs vial, aluminium lid and plug are carried out dry heat sterilization aborning, easily material is damaged, and the part cast may enter into aseptic subpackaged raw material, influences patient's safety in utilization.
CN102716082A discloses a kind of cefoxitin sodium lipidosome injection and method for making thereof, makes the cefoxitin sodium lipidosome injection of excellent quality by cefoxitin sodium, Phosphatidylserine, cholesterol, poloxamer 188, the trehalose of selecting the specified weight proportioning for use.But, but poloxamer 188, trehalose do not have the product of injection at present, and its safety is worth worry.
CN102755325A relates to a kind of cefoxitin sodium pharmaceutical composition, its injectable powder and preparation method thereof.This pharmaceutical composition is made up of cefoxitin sodium, histidine and HP-.But HP-limits use in injection, its nephrotoxicity may bring harm to the patient.
Summary of the invention
At the sterilization process deficiency of the aseptic subpackaged cefoxitin sodium for injection that obtains because of its packing material, the inventor considers if prepare the cefoxitin sodium for injection lyophilized injectable powder, will well solve this technical problem.Cefoxitin sodium is very easily dissolving in water, if be prepared into lyophilized injectable powder, then needs to guarantee to make up a prescription, the stability in lyophilizing and the storage process.Therefore, the object of the present invention is to provide a kind of cefoxitin sodium for injection lyophilized injectable powder and preparation technology thereof of good stability.
For guarantee to make up a prescription, stability in lyophilizing and the storage process, the inventor has finally obtained the technical scheme of following realization the object of the invention unexpectedly by lot of experiments:
A kind of cefoxitin sodium for injection lyophilized injectable powder is formed by the medicinal liquid lyophilizing that contains cefoxitin sodium, and it is characterized in that: described medicinal liquid is regulated pH=6.0-7.0 by histidine.
Preferably, above-mentioned cefoxitin sodium for injection lyophilized injectable powder, wherein said medicinal liquid is regulated pH=6.5-7.0 by histidine.
Further preferably, above-mentioned cefoxitin sodium for injection lyophilized injectable powder, the concentration of cefoxitin sodium is 0.1-0.5g/mL in the wherein said medicinal liquid.
Second purpose of the present invention is to provide the preparation method of above-mentioned cefoxitin sodium for injection lyophilized injectable powder, and this method comprises the steps:
(1) wash bottle sterilizing-drying: earlier cillin bottle is passed through the ultrasonic bottle washing machine washes clean, by sterilizing and drying machine sterilizing and drying, it is standby to reach bottling department;
(2) butyl rubber plug is handled: with butyl rubber plug after rubber plug cleaning machine cleans up, 121 ℃ of hot steam sterilizers 20 minutes, drying for standby;
(3) aluminium-plastic cap is handled: through the washing of aluminium lid cleaning machine, sterilization is dried, and takes out standby with aluminium-plastic cap;
(4) preparation of medicinal liquid: take by weighing cefoxitin sodium, add in the water for injection that is chilled to 5-25 ℃ stirring and dissolving, add histidine, regulate the medicinal liquid pH value in 6.0～7.0 scopes, circulating filtration, sample presentation detects semi-finished product medicinal liquid content, 0.2 μ m microporous filter membrane aseptic filtration;
(5) fill, jump a queue: earlier the freeze dryer flaggy is cooled to below-40 ℃ in advance, fill in every cillin bottle contains the medicinal liquid of cefoxitin 1g according to medicinal liquid content, and the false add plug is put into freeze dryer with sample, lyophilizing;
(6) roll lid: the sample lyophilizing compresses plug under the vacuum after finishing, and bleeds off the vacuum in the freeze dryer, takes out sample, rolls aluminium lid outward, gets finished product.
Preferably, the preparation method of above-mentioned cefoxitin sodium for injection lyophilized injectable powder is wherein regulated the medicinal liquid pH value in 6.5～7.0 scopes in the step (4).
Compared with prior art, the cefoxitin sodium for injection lyophilized injectable powder that the present invention relates to has following advantage and marked improvement:
(1) safe.The inventor is creationary to provide a kind of cefoxitin sodium for injection lyophilized injectable powder, has avoided the foreign body that cillin bottle, plug etc. causes being come off because of high temperature sterilize in aseptic subpackaged; The adjuvant that adopts injectable to use simultaneously, the safety of raising medication.
(2) good stability.Do not detect visible foreign matters in the product of the present invention preparation, related substance is lower, and related substance changes not obviously after accelerating to investigate 6 months, and visible foreign matters does not detect.
Specific embodiment
Below be specific embodiments of the invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Cefoxitin sodium 1000g(is in cefoxitin)
Histidine is an amount of
Water for injection 2000ml
Preparation technology:
The wash bottle sterilizing-drying: earlier cillin bottle is passed through the ultrasonic bottle washing machine washes clean, by sterilizing and drying machine sterilizing and drying, it is standby to reach bottling department;
Butyl rubber plug is handled: with butyl rubber plug after rubber plug cleaning machine cleans up, 121 ℃ of hot steam sterilizers 20 minutes, drying for standby;
Aluminium-plastic cap is handled: through the washing of aluminium lid cleaning machine, sterilization is dried, and takes out standby with aluminium-plastic cap;
The preparation of medicinal liquid: the cefoxitin sodium that takes by weighing recipe quantity, add in the water for injection that is chilled to 5 ℃, stirring and dissolving adds an amount of histidine, and regulating the medicinal liquid pH value is 6.0, circulating filtration,, sample presentation detects semi-finished product medicinal liquid content, will determine that the medicinal liquid of content is through 0.2 μ m microporous filter membrane aseptic filtration, determine the fill amount according to content, with to be filled;
Fill, jump a queue: earlier the freeze dryer flaggy is cooled to below-40 ℃ in advance, fill in every cillin bottle contains the medicinal liquid of cefoxitin 1g according to medicinal liquid content, and the false add plug is put into freeze dryer with sample, lyophilizing;
Roll lid: the sample lyophilizing compresses plug under the vacuum after finishing, and bleeds off the vacuum in the freeze dryer, takes out sample, rolls aluminium lid outward, gets finished product.
Embodiment 2
Cefoxitin sodium 1000g(is in cefoxitin)
Histidine is an amount of
Water for injection 2000ml
Preparation technology:
The wash bottle sterilizing-drying: earlier cillin bottle is passed through the ultrasonic bottle washing machine washes clean, by sterilizing and drying machine sterilizing and drying, it is standby to reach bottling department;
Butyl rubber plug is handled: with butyl rubber plug after rubber plug cleaning machine cleans up, 121 ℃ of hot steam sterilizers 20 minutes, drying for standby;
Aluminium-plastic cap is handled: through the washing of aluminium lid cleaning machine, sterilization is dried, and takes out standby with aluminium-plastic cap;
The preparation of medicinal liquid: the cefoxitin sodium that takes by weighing recipe quantity, add in the water for injection that is chilled to 25 ℃, stirring and dissolving adds an amount of histidine, and regulating the medicinal liquid pH value is 7.0, circulating filtration,, sample presentation detects semi-finished product medicinal liquid content, will determine that the medicinal liquid of content is through 0.2 μ m microporous filter membrane aseptic filtration, determine the fill amount according to content, with to be filled;
Fill, jump a queue: earlier the freeze dryer flaggy is cooled to below-40 ℃ in advance, fill in every cillin bottle contains the medicinal liquid of cefoxitin 1g according to medicinal liquid content, and the false add plug is put into freeze dryer with sample, lyophilizing;
Roll lid: the sample lyophilizing compresses plug under the vacuum after finishing, and bleeds off the vacuum in the freeze dryer, takes out sample, rolls aluminium lid outward, gets finished product.
Embodiment 3
Cefoxitin sodium 1000g(is in cefoxitin)
Histidine is an amount of
Water for injection 2000ml
Preparation technology:
The wash bottle sterilizing-drying: earlier cillin bottle is passed through the ultrasonic bottle washing machine washes clean, by sterilizing and drying machine sterilizing and drying, it is standby to reach bottling department;
Butyl rubber plug is handled: with butyl rubber plug after rubber plug cleaning machine cleans up, 121 ℃ of hot steam sterilizers 20 minutes, drying for standby;
Aluminium-plastic cap is handled: through the washing of aluminium lid cleaning machine, sterilization is dried, and takes out standby with aluminium-plastic cap;
The preparation of medicinal liquid: the cefoxitin sodium that takes by weighing recipe quantity, add in the water for injection that is chilled to 5 ℃, stirring and dissolving adds an amount of histidine, regulates the medicinal liquid pH value 6.5, circulating filtration,, sample presentation detects semi-finished product medicinal liquid content, will determine that the medicinal liquid of content is through 0.2 μ m microporous filter membrane aseptic filtration, determine the fill amount according to content, with to be filled;
Fill, jump a queue: earlier the freeze dryer flaggy is cooled to below-40 ℃ in advance, fill in every cillin bottle contains the medicinal liquid of cefoxitin 1g according to medicinal liquid content, and the false add plug is put into freeze dryer with sample, lyophilizing;
Roll lid: the sample lyophilizing compresses plug under the vacuum after finishing, and bleeds off the vacuum in the freeze dryer, takes out sample, rolls aluminium lid outward, gets finished product.
The comparative example 1
1) wash bottle operation: ultrasound wave previous cleaning, adopting hydraulic pressure after previous cleaning is finished is the purified water flushing of 0.2Mpa, adopting hydraulic pressure then is the water for injection flushing through the filtration of 0.2 μ m filter of 0.25Mpa, adopt the compressed air through 0.22 μ m filter filtration, purification of 0.3Mpa to dry up at last, after drying up injection bottle bottleneck is overturn up bottle outlet; Under hundred grades of laminar flow protections, send into the infrared ray sterilization drier and carry out dry sterilization;
2) plug treatment process: with outer package remove the back plug through full-automatic rubber plug cleaning machine clean, sterilize, dry, standby after cooling off;
3) aluminium lid treatment process: aluminium lid is poured in the clean porose rustless steel basket, put into electrically heated drying cabinet, sterilization;
4) cefoxitin sodium packing operation: the surface of the former powder bucket of wiping cefoxitin sodium/bag, carry out the wiping sterilization with disinfectant then; It is stand-by to adopt ultra violet lamp to enter 10,000 grades of aseptic areas after 30 minutes at pass-through box; Hundred grades of laminar flows were opened in packing in preceding 30 minutes, with 75% ethanol the wiping sterilization were carried out on the surface of former powder bucket/bag at temporary room, sent into the packing chamber; Under hundred grades of laminar flows, former powder is transferred in the powder bucket; The temperature of control packing chamber is 22 ± 4 ℃, and relative humidity is below 65%, and the technology passageway keeps the above relative negative pressure of 5Pa; With operation 1) in injection bottle after the drying sterilization when sending into the packing track, charge into the nitrogen that filters through 0.22 μ m film filter to empty bottle earlier, behind the empty bottle packing medicine, charge into nitrogen to medicine again, cover then through operation 2) plug handled; Debugged racking machine according to the standard loading amount of calculating and carried out packing, sent into then and roll cover chamber and roll lid and namely get cefoxitin sodium for injection, rolled the used aluminium lid of lid for through operation 3) aluminium lid of processing.
The comparative example 2
Preparation technology
The wash bottle sterilizing-drying: earlier cillin bottle is passed through the ultrasonic bottle washing machine washes clean, by sterilizing and drying machine sterilizing and drying, it is standby to reach bottling department;
Butyl rubber plug is handled: with butyl rubber plug after rubber plug cleaning machine cleans up, 121 ℃ of hot steam sterilizers 20 minutes, drying for standby;
Aluminium-plastic cap is handled: through the washing of aluminium lid cleaning machine, sterilization is dried, and takes out standby with aluminium-plastic cap;
The preparation of medicinal liquid: the potassium dihydrogen phosphate that takes by weighing recipe quantity, add 5 ℃ water for injection to preparing total amount, sodium hydroxide is regulated the medicinal liquid pH value should be 6.5, stir, dissolve, adding 0.1%(g/v) needle-use activated carbon, stirred 20 minutes, decarbonization filtering, the cefoxitin sodium of adding recipe quantity, it is 6.5 that sodium hydroxide or hydrochloric acid solution are regulated pH, stirring and dissolving, circulating filtration, sample presentation detect semi-finished product medicinal liquid content, will determine that the medicinal liquid of content is through 0.2 μ m microporous filter membrane aseptic filtration, determine the fill amount according to content, with to be filled;
Fill, jump a queue: earlier the freeze dryer flaggy is cooled to below-40 ℃ in advance, fill in every cillin bottle contains the medicinal liquid of cefoxitin 1g according to medicinal liquid content, and the false add plug is put into freeze dryer with sample, lyophilizing;
Roll lid: the sample lyophilizing compresses plug under the vacuum after finishing, and bleeds off the vacuum in the freeze dryer, takes out sample, rolls aluminium lid outward, gets finished product.
Embodiment 4
1, visible foreign matters.Measure according to pharmacopeia visible foreign matters inspection technique.The results are shown in Table 1.
2, determination of related substances.
Get the about 50mg of sample of embodiment 1-3 and comparative example 1-2 preparation respectively, the accurate title, decide, put in the 10ml measuring bottle, add phosphate buffer and (take by weighing dipotassium hydrogen phosphate 34.836g, add water 1000ml dissolving, regulate pH value to 6.8 with phosphoric acid, get 20ml, be diluted with water to 1000ml) dissolve and be diluted to scale, shake up, filter, as need testing solution; Precision is measured 1.0ml, puts in the 100ml measuring bottle, is diluted to scale with above-mentioned phosphate buffer, shakes up, in contrast solution.Measuring according to high performance liquid chromatography (appendix VD), is filler with the phenyl bonded silica gel; Mobile phase A is water (transferring pH to 2.7 with formic acid), and Mobile phase B is acetonitrile; The detection wavelength is 235nm.
It is an amount of to get the cefoxitin reference substance, with the dissolving of above-mentioned phosphate buffer and be diluted to the solution that contains cefoxitin 0.25mg among every lml approximately, placed 1 hour at 70 ℃, be cooled to room temperature, get 20 μ l and annotate people's chromatograph of liquid, the record chromatogram, the retention time at cefoxitin peak is about 35 minutes, and cefoxitin peak and its relative retention time are about the separating degree of the impurity peaks at 0.8 place should be greater than 5.0.Get contrast solution 20 μ l and annotate people's chromatograph of liquid, regulate detection sensitivity, make the peak height of main constituent chromatographic peak be about 20% of full scale, precision is measured need testing solution and each 20 μ l of contrast solution again, annotates people's chromatograph of liquid respectively, the record chromatogram.If any impurity peaks, single impurity peak area must not be greater than 0.5 times (0.5%) of contrast solution main peak area in the need testing solution chromatogram, and in the need testing solution chromatogram can ignore in any peak less than 0.05 times of contrast solution main peak area.The results are shown in Table 1.
Table 1 accelerates visible foreign matters and the determination of related substances result of experiment front and back sample
From the experimental result of table 1 as can be seen, the cefoxitin sodium freeze-dried powder injection visible foreign matters of embodiment of the invention 1-3 preparation does not detect, and related substance is better, and through accelerating to investigate 6 months, related substance increases a little, and visible foreign matters does not detect; Comparative example 1 adopts aseptic subpackaged, and visible foreign matters is defective; Comparative example 2 adopts phosphate buffer to regulate medicinal liquid pH, and related substance increases obviously after accelerating The effects.
Claims (5)
1. a cefoxitin sodium for injection lyophilized injectable powder is formed by the medicinal liquid lyophilizing that contains cefoxitin sodium, and it is characterized in that: described medicinal liquid is regulated pH=6.0-7.0 by histidine.
2. cefoxitin sodium for injection lyophilized injectable powder according to claim 1, it is characterized in that: described medicinal liquid is regulated pH=6.5-7.0 by histidine.
3. cefoxitin sodium for injection lyophilized injectable powder according to claim 1, it is characterized in that: the concentration of cefoxitin sodium is 0.1-0.5g/mL in the described medicinal liquid.
4. according to the preparation method of claim 1 or 3 described cefoxitin sodium for injection lyophilized injectable powders, it is characterized in that comprising the steps:
(1) wash bottle sterilizing-drying: earlier cillin bottle is passed through the ultrasonic bottle washing machine washes clean, by sterilizing and drying machine sterilizing and drying, it is standby to reach bottling department;
(2) butyl rubber plug is handled: with butyl rubber plug after rubber plug cleaning machine cleans up, 121 ℃ of hot steam sterilizers 20 minutes, drying for standby;
(3) aluminium-plastic cap is handled: through the washing of aluminium lid cleaning machine, sterilization is dried, and takes out standby with aluminium-plastic cap;
(4) preparation of medicinal liquid: take by weighing cefoxitin sodium, add in the water for injection that is chilled to 5-25 ℃ stirring and dissolving, add histidine, regulate the medicinal liquid pH value in 6.0～7.0 scopes, circulating filtration, sample presentation detects semi-finished product medicinal liquid content, 0.2 μ m microporous filter membrane aseptic filtration;
(5) fill, jump a queue: earlier the freeze dryer flaggy is cooled to below-40 ℃ in advance, fill in every cillin bottle contains the medicinal liquid of cefoxitin 1g according to medicinal liquid content, and the false add plug is put into freeze dryer with sample, lyophilizing;
(6) roll lid: the sample lyophilizing compresses plug under the vacuum after finishing, and bleeds off the vacuum in the freeze dryer, takes out sample, rolls aluminium lid outward, gets finished product.
5. the preparation method of cefoxitin sodium for injection lyophilized injectable powder according to claim 4 is characterized in that: regulate the medicinal liquid pH value in the step (4) in 6.5～7.0 scopes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102065472A CN103263389A (en) | 2013-05-29 | 2013-05-29 | Cefoxitin sodium freeze-dried powder injection for injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102065472A CN103263389A (en) | 2013-05-29 | 2013-05-29 | Cefoxitin sodium freeze-dried powder injection for injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103263389A true CN103263389A (en) | 2013-08-28 |
Family
ID=49007087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013102065472A Pending CN103263389A (en) | 2013-05-29 | 2013-05-29 | Cefoxitin sodium freeze-dried powder injection for injection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103263389A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107095851A (en) * | 2017-04-26 | 2017-08-29 | 四川制药制剂有限公司 | The preparation technology of Ceftezole sodium used for injection sterile powder injection |
| CN107651251A (en) * | 2017-08-31 | 2018-02-02 | 芜湖杨燕制药有限公司 | A kind of insect-expelling saligna injection liquid filling sterilizing technique |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593423A (en) * | 2004-06-18 | 2005-03-16 | 余安国 | Cefixime pharmaceutical composition for injection |
| CN1660116A (en) * | 2004-12-24 | 2005-08-31 | 邢为藩 | New combination of Cefpirome Sulfate and preparation method |
| CN101559040A (en) * | 2008-04-18 | 2009-10-21 | 汪娟 | Medicament composition of cefotiam hydrochloride and preparation thereof |
| CN102058601A (en) * | 2010-12-06 | 2011-05-18 | 南京海陵中药制药工艺技术研究有限公司 | Cefpodoxime composition for injection |
| CN102755325A (en) * | 2012-07-04 | 2012-10-31 | 深圳信立泰药业股份有限公司 | Cefoxitin sodium medicinal composition, powder injection and preparation method thereof |
-
2013
- 2013-05-29 CN CN2013102065472A patent/CN103263389A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593423A (en) * | 2004-06-18 | 2005-03-16 | 余安国 | Cefixime pharmaceutical composition for injection |
| CN1660116A (en) * | 2004-12-24 | 2005-08-31 | 邢为藩 | New combination of Cefpirome Sulfate and preparation method |
| CN101559040A (en) * | 2008-04-18 | 2009-10-21 | 汪娟 | Medicament composition of cefotiam hydrochloride and preparation thereof |
| CN102058601A (en) * | 2010-12-06 | 2011-05-18 | 南京海陵中药制药工艺技术研究有限公司 | Cefpodoxime composition for injection |
| CN102755325A (en) * | 2012-07-04 | 2012-10-31 | 深圳信立泰药业股份有限公司 | Cefoxitin sodium medicinal composition, powder injection and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107095851A (en) * | 2017-04-26 | 2017-08-29 | 四川制药制剂有限公司 | The preparation technology of Ceftezole sodium used for injection sterile powder injection |
| CN107651251A (en) * | 2017-08-31 | 2018-02-02 | 芜湖杨燕制药有限公司 | A kind of insect-expelling saligna injection liquid filling sterilizing technique |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102895182B (en) | Method for preparing cefoxitin sodium for injection | |
| TWI476013B (en) | Process for preparing pharmaceutical formulation in form of antioxidant-free solution for injection containing pemetrexed or its salt | |
| CN101411710B (en) | Pemetrexed disodium freeze-dried injection and preparation method thereof | |
| CN103349646B (en) | A kind of pharmaceutical composition of cefaclor granule, its preparation method and application | |
| CN103211771B (en) | Lyophilized injectable powder of a kind of Ramosetron HCl and preparation method thereof | |
| CN103432066A (en) | Compound mannitol injection and preparation method thereof | |
| CN103263389A (en) | Cefoxitin sodium freeze-dried powder injection for injection and preparation method thereof | |
| CN101411864A (en) | Thymopentin dry powder formulation and preparation method thereof | |
| CN101627967B (en) | Ambroxol hydrochloride liquid preparation and preparation method thereof | |
| CN105147599B (en) | Netilmicin sulfate injection and preparation method | |
| CN114306258B (en) | Acarbose solid oral preparation and preparation method thereof | |
| CN102743342B (en) | Sodium fusidate lyophilized composition for injection | |
| CN105213301B (en) | Netilmicin sulfate injection and its quality control method | |
| CN108066338A (en) | New antibiotic composition when prevention and treatment aerobic bacteria and anaerobic bacteria mixed infection and preparation method thereof | |
| CN103432086B (en) | Pemetrexed disodium freeze-dried powder injection for injection and preparation method thereof | |
| CN100386079C (en) | Injection use-powder ampoule for inhibiting thrombocyte agglutination and its preparation method | |
| CN107714664A (en) | Aspirin-Al-lysine for injection freeze drying powder injection and preparation method thereof | |
| CN103462907A (en) | Omeprazole sodium freeze-dried powder injection for injection and preparation method thereof | |
| CN103565747B (en) | Esomeprazole composition and preparation method thereof | |
| CN103432121A (en) | Preparation method of amoxicillim sodium and sulbactam sodium for injection | |
| CN103446065A (en) | Esomeprazole sodium freeze-dried powder injection for injection and preparation method thereof | |
| CN105055169B (en) | A method of preparing Imipenem and Cilasatin Sodium aseptic powdery | |
| CN102429860A (en) | Double-cavity bag packed cefpirome sulfate injection and preparation method thereof | |
| CN103301123A (en) | Preparation method for controlling pH (Potential of Hydrogen) of amoxicillin sodium/sulbactam sodium | |
| CN104382849B (en) | A kind of cefaclor dry suspension and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130828 |