CN103261442A - Hpv 精确分型的生物信息学分析的方法及系统 - Google Patents

Hpv 精确分型的生物信息学分析的方法及系统 Download PDF

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CN103261442A
CN103261442A CN2010800704847A CN201080070484A CN103261442A CN 103261442 A CN103261442 A CN 103261442A CN 2010800704847 A CN2010800704847 A CN 2010800704847A CN 201080070484 A CN201080070484 A CN 201080070484A CN 103261442 A CN103261442 A CN 103261442A
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sequence
sample
sequencing
fragment
hpv
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CN103261442B (zh
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刘智盛
田仕林
潘荣
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Huada biological technology (Wuhan) Co., Ltd.
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BGI Shenzhen Co Ltd
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

本发明公开一种HPV精确分型的生物信息学分析的方法及系统，该方法包括：接收高通量测序技术得到的测序片段；将测序片段中的样本接头序列与样本接头序列库进行比对，实现分样本操作；将测序片段与参考基因组序列进行比对，对比对后的序列进行筛选，确定筛选后的序列片段的HPV型别或阴性；对确定型别的序列片段按样本进行合并，并根据合并后支持对应型别的序列片段数量和比例进行筛选；最终确认每个样本的HPV型别或者确定为阴性。本发明提供的HPV精确分型的生物信息学分析的方法及系统，利用生物信息学的分析方法及技术手段，实现了快速检测大量样本、快速完成对感染HPV型别的检测，具有较高的灵敏度和特异性。

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PCT国内申请，说明书已公开。

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  1. PCT国内申请，权利要求书已公开。
CN201080070484.7A 2010-12-02 2010-12-02 Hpv 精确分型的生物信息学分析的方法及系统 Active CN103261442B (zh)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019047109A1 (zh) * 2017-09-07 2019-03-14 深圳华大基因股份有限公司 一种hpv精确分型的生物信息学分析方法及系统
CN110951853A (zh) * 2019-12-10 2020-04-03 中山大学附属第一医院 一种精确检测人基因组中dna病毒的方法
CN111755075A (zh) * 2019-03-28 2020-10-09 深圳华大生命科学研究院 对免疫组库高通量测序样本间序列污染进行过滤的方法
CN111919257A (zh) * 2018-07-27 2020-11-10 思勤有限公司 降低测序数据中的噪声
CN116403647A (zh) * 2023-06-08 2023-07-07 上海精翰生物科技有限公司 一种检测慢病毒整合位点的生物信息检测方法及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374963A (zh) * 2005-12-22 2009-02-25 凯津公司 用于基于aflp的高通量多态性检测的方法
CN101397590A (zh) * 2008-10-27 2009-04-01 杭州迪安医学检验中心有限公司 人乳头状瘤病毒基因分型方法
CN101435002A (zh) * 2008-12-12 2009-05-20 深圳华大基因科技有限公司 一种检测人类乳头瘤病毒基因型的方法
CN101838709A (zh) * 2010-04-13 2010-09-22 中山大学 一种微量hpv快速基因分型方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374963A (zh) * 2005-12-22 2009-02-25 凯津公司 用于基于aflp的高通量多态性检测的方法
CN101397590A (zh) * 2008-10-27 2009-04-01 杭州迪安医学检验中心有限公司 人乳头状瘤病毒基因分型方法
CN101435002A (zh) * 2008-12-12 2009-05-20 深圳华大基因科技有限公司 一种检测人类乳头瘤病毒基因型的方法
CN101838709A (zh) * 2010-04-13 2010-09-22 中山大学 一种微量hpv快速基因分型方法

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019047109A1 (zh) * 2017-09-07 2019-03-14 深圳华大基因股份有限公司 一种hpv精确分型的生物信息学分析方法及系统
CN111032885A (zh) * 2017-09-07 2020-04-17 深圳华大基因股份有限公司 一种hpv精确分型的生物信息学分析方法及系统
CN111032885B (zh) * 2017-09-07 2024-05-17 深圳华大基因股份有限公司 一种hpv精确分型的生物信息学分析方法及系统
CN111919257A (zh) * 2018-07-27 2020-11-10 思勤有限公司 降低测序数据中的噪声
CN111919257B (zh) * 2018-07-27 2021-05-28 思勤有限公司 降低测序数据中的噪声的方法和系统及其实施和应用
CN111755075A (zh) * 2019-03-28 2020-10-09 深圳华大生命科学研究院 对免疫组库高通量测序样本间序列污染进行过滤的方法
CN111755075B (zh) * 2019-03-28 2023-09-29 深圳华大生命科学研究院 对免疫组库高通量测序样本间序列污染进行过滤的方法
CN110951853A (zh) * 2019-12-10 2020-04-03 中山大学附属第一医院 一种精确检测人基因组中dna病毒的方法
CN110951853B (zh) * 2019-12-10 2021-03-30 中山大学附属第一医院 一种精确检测人基因组中dna病毒的方法
WO2021114186A1 (zh) * 2019-12-10 2021-06-17 中山大学附属第一医院 一种精确检测人基因组中dna病毒的方法
CN116403647A (zh) * 2023-06-08 2023-07-07 上海精翰生物科技有限公司 一种检测慢病毒整合位点的生物信息检测方法及其应用
CN116403647B (zh) * 2023-06-08 2023-08-15 上海精翰生物科技有限公司 一种检测慢病毒整合位点的生物信息检测方法及其应用

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HK1185113A1 (zh) 2014-02-07
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