CN103251594B - Repaglinide/metformin combo tablet - Google Patents
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- CN103251594B CN103251594B CN201310219929.9A CN201310219929A CN103251594B CN 103251594 B CN103251594 B CN 103251594B CN 201310219929 A CN201310219929 A CN 201310219929A CN 103251594 B CN103251594 B CN 103251594B
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Abstract
The invention relates to a repaglinide/metformin combo tablet, particularly a pharmaceutical composition in the form of a tablet, which comprises the following components in parts by weight: 500 parts of metformin hydrochloride, 0.5-5 parts of repaglinide and 10-200 parts of medicinal auxiliary materials. The medicinal auxiliary materials include, but are not limited to filler, disintegrant, binding agent, alkali and lubricant. The invention also relates to a method for preparing the pharmaceutical composition. The pharmaceutical composition provided by the invention has favorable pharmaceutical properties.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of by repaglinide and metformin the tablet medicine composition and method of making the same as active ingredient.
Background technology
Repaglinide (English name Repaglinide), its chemical name is: S (+)-2-ethyoxyl-4-{2-[(3-methyl isophthalic acid-(2-(piperidino) phenyl) butyl) amino]-2-oxoethyl } benzoic acid.Molecular formula: C27H36N2O4, molecular weight: 452.59, its structural formula is as follows:
Repaglinide is benzoic acid derivative, non-sulfonylurea Drugs Promoting Insulin Secretion, be one effect new oral hypoglycemic medicine rapidly, the 36KDA protein-specific outside d cell film on the potassium-channel of dependency ATP is combined, and potassium channel is closed, D cell depolarization, calcium channel is open, and flow of calcium ions promotes insulin secretion, it acts on faster than sulfonylurea, therefore hypoglycemic activity is fast after the meal.
Metformin (Metformin), conventional its hydrochlorate clinically, i.e. metformin hydrochloride, chemistry 1,1-Dimethylbiguanide hydrochloride by name, its structural formula is as follows:
Metformin is biguanides hypoglycemic drug, is the common medicine that one is used for the treatment of non-insulin-depending type (II type) diabetes.Because it can obviously reduce the blood glucose of diabetics, and can reduce the danger of the vascular complication that diabetes are relevant, reduce the incidence rate that impaired glucose tolerance patients develops into diabetes, and side effect is less, in the global type 2 diabetes mellitus treatment guide of the up-to-date promulgation of IDF in 2005, in the prevention and treatment of diabetes, the effect of metformin is extremely paid attention to.Metformin hypoglycemic medicine mechanism of action comprises: 1. promote the utilization of surrounding tissue cell (muscle etc.) to glucose; 2. suppress gluconeogenesis function of liver, therefore reduce glycogen output; 8. suppress intestinal wall cellular uptake glucose, different from insulin action, this product, without the effect that impels lipogenesis, without obvious hypoglycemic activity, therefore, does not generally cause hypoglycemia to normal person.Metformin can be used for diet-treated only unsatisfied non-insulin-dependent diabetes mellitus people, especially overweight people, not only has hypoglycemic activity with this class medicine, also may have slimming effect.Metformin accounts for respectively 25% and 28% of all oral antidiabetic drug at the sales volume of Europe and the U.S..Over nearly 10 years, medical circle has had new understanding gradually to the pharmacological action of metformin and its some advantage in clinical treatment diabetes, and particularly it,, in the effect improving aspect insulin resistant, is that sulfonylureas drugs for diabetes is unexistent.Because its blood sugar reducing function does not rely on insulin, it is the glyconeogenesis by suppressing liver and impels the picked-up utilization of periphery insulin target tissue to glucose, to improve the insulin sensitivity of body.Metformin hydrochloride can reduce diabetes patient's hyperglycemia, but in the time that blood glucose is normal, can not make again blood glucose reduce again.Therefore, use separately metformin not have hypoglycemic reaction.Therefore, metformin now become gently, moderate type 2 diabetes mellitus patient's, particularly obese patient first-selected curative.There are some researches show, metformin can increase the secretion of glucagon kind polypeptide-1 (GLP-1), GLP-1 can promote the insulin secretion of type 2 diabetes mellitus patient glucose mediation, glucagon suppression secretion, promote that hepatic glycogen is synthetic and reduce glycogen output, improve B cell function, alleviate hyperinsulinemia.
The document of Gu Ming (metformin and repaglinide (NovoNorm) use in conjunction is known from experience [J]. the healthy digest in China and foreign countries, 2008 08 month the 5th the 8th phase of volume) in think, co-administrated metformin repaglinide has synergism, do not make again the side reaction such as hypoglycemia, body weight increase increase, hepatic and renal function is also harmless, therefore be safety, the effective and good combined treatment of toleration, be worthy to be popularized.
Repaglinide/metformin Compound Tablet (PrandiMet) listing of FDA approval Novo Nordisk Co.,Ltd (Novo Nordisk), is used for the treatment of type 2 diabetes mellitus.The dosage specification of this compound tablet is repaglinide/metformin hydrochloride 1mg/500mg or 2mg/500mg.This tablet be first be also so far unique get permission listing quick-acting short secretion medicine repaglinide and the dose formulations of euglycemic agent metformin hydrochloride.The repaglinide of this compound tablet 1mg/500mg and 2mg/500mg and corresponding dosage and metformin hydrochloride single medicine preparation coupling bioequivalence similar temperament.
Two medicines share the control successful of HbAlc, FPG and 2hPG higher than alone repaglinide or alone metformin hydrochloride.Repaglinide and metformin have share synergism, for the type 2 diabetes mellitus patient of oral other antidiabetic drug unsatisfactory curative effects, can select two medicines to share.
CN101516347A (Chinese Patent Application No. 200780036006.2, Nuo Wo-Nuo Disike) discloses a kind of pharmaceutical preparation that comprises metformin and repaglinide.This invention relates to pharmaceutical composition, comprise repaglinide, it is unit dosage forms in conjunction with metformin or its salt, and wherein the preformulation of repaglinide had the dissolution characteristic irrelevant with pH value and is less than about 25% relative humidity before mixing with metformin or its salt; With choose any one kind of them or multiple pharmaceutically acceptable excipient, also relate to its preparation method.
CN101756971A (Chinese Patent Application No. 200810224002.3, German public is perfectly sound) a kind of oral solid drug composition that contains metformin hydrochloride and repaglinide disclosed, it contains pharmaceutically acceptable carrier, its preparation technology is simple, efficiently solve sliver, simultaneously repaglinide content uniformity, dissolution are good, for the treatment of type ii diabetes.This solid composite medicament, contains metformin hydrochloride and pharmaceutically acceptable carrier that repaglinide and particle diameter D90 are 10um-200um.
CN101822672A (Chinese Patent Application No. 200910105692.5, south be full of letter) discloses a kind of compound taking metformin hydrochloride and repaglinide as active ingredient and its production and use.This compound is taking metformin hydrochloride and repaglinide as medicinal active ingredient, the Pharmaceutical composition being mixed to form with carrier, and can be prepared into slow releasing tablet, slow-releasing granules, slow releasing capsule, conventional tablet, capsule; The oral formulations such as granule, dispersible tablet, chewable tablet, oral cavity disintegration tablet, buccal tablet, liquid capsule, soft capsule, drop pill.This compound, for type i diabetes or type ii diabetes (non-insulin is according to patience) patient's treatment, has synergism to controlling blood glucose.
CN102218064A (Chinese Patent Application No. 201110100196.8, Hainan brocade is auspicious) relate to a kind of by repaglinide and metformin as Pharmaceutical composition of active ingredient and preparation method thereof, this Pharmaceutical composition comprises a) medicament active composition repaglinide and metformin and b) pharmaceutic adjuvant; The weight portion of described active constituents of medicine is 0.1～10 part of repaglinide, 100～1500 parts of metformin; Described pharmaceutic adjuvant is filler, disintegrating agent, binding agent, correctives, lubricant and swellability adjuvant; Wherein said repaglinide is repaglinide crystal.The Pharmaceutical composition that this invention adopts the very little repaglinide crystal of particle diameter to be prepared from metformin and pharmaceutic adjuvant can be realized and synchronize the object of release, and because the repaglinide of this invention is the crystal that particle diameter is very little, dissolubility has obtained obvious improvement, thereby improve dissolution, improved bioavailability.
But because repaglinide dissolubility is little, dissolubility in water is 0.005mg/mL, and metformin hydrochloride is water soluble drug, can cause metformin hydrochloride rate of releasing drug suitable if adopt conventional technique to carry out tabletting, repaglinide will can not discharge out.And repaglinide rate of releasing drug is suitable, will loses control of the release of metformin hydrochloride, and cause the prominent of metformin hydrochloride to be released.For this reason, repaglinide, metformin hydrochloride are adopted respectively different framework material compacting double-layer sustained release tablets by CN101843617A, obtaining two medicines all has the formulation and technology of suitable rate of releasing drug, or repaglinide, metformin hydrochloride are adopted respectively to different framework materials compressed minitablets respectively, then fill capsule proportionally, to solve the problem of insoluble drug repaglinide and water soluble drug metformin hydrochloride synchronous slow.
The shortcoming of above-mentioned double-layer sustained release tablets or respectively compressed minitablets is that its preparation is too high to equipment requirements, is difficult to suitability for industrialized production, even product is introduced to the market, also will cause needs of patients to pay great number medical expense; And double-layer sustained release tablets can cause tablet hardness excessive in preparation process, affect drug release, Dual-layer sheet joint face is difficult to discharge medicine.And because repaglinide is almost insoluble in water, cause vitro Drug dissolution poor, cause its bioavailability low.
In the compound tablet that comprises repaglinide and metformin, the weight of two kinds of active component differs greatly, and for the uniformity of the repaglinide of low dosage is uniformity of dosage units, being needs to consider especially; Repaglinide poorly soluble and metformin dissolubility is very good in addition, there is larger difference in the two, can cause thus the onset time of tablets latter two medicine inconsistent on the dissolving out capability of tablet.The problems referred to above are all that those skilled in the art extremely will pay close attention to.The method of the new compound tablet of preparing repaglinide and metformin is still expected to have in this area, and tablet prepared by expectation the method has the superperformance of one or more aspects.
Summary of the invention
The object of the present invention is to provide a kind of method of the new compound tablet of preparing repaglinide and metformin, tablet prepared by expectation the method has the superperformance of one or more aspects.The inventor has been surprisingly found that, uses the compound tablet that comprises repaglinide and metformin that specific method prepares to have challenging superior function.Therefore the present invention finds and is accomplished.
For this reason, first aspect present invention provides a kind of pharmaceutical composition, wherein comprises: metformin hydrochloride, repaglinide and pharmaceutic adjuvant.
According to the pharmaceutical composition of first aspect present invention any one, wherein comprise: the pharmaceutic adjuvant of the metformin hydrochloride of 500 weight portions, the repaglinide of 0.5～5 weight portion and 10～200 weight portions.
According to the pharmaceutical composition of first aspect present invention any one, wherein comprise: the pharmaceutic adjuvant of the metformin hydrochloride of 500 weight portions, the repaglinide of 0.5～2.5 weight portion and 20～150 weight portions.
According to the pharmaceutical composition of first aspect present invention any one, wherein said pharmaceutic adjuvant includes but not limited to filler, disintegrating agent, binding agent, alkaline agent, lubricant.
According to the pharmaceutical composition of first aspect present invention any one, wherein said pharmaceutic adjuvant also comprises solubilizing agent.
According to the pharmaceutical composition of first aspect present invention any one, wherein, the amount of described disintegrating agent can particularly easily be determined according to existing knowledge and experience when tablet in pharmaceutical compositions according to those skilled in the art.The amount of for example disintegrating agent can be to account for 1%～20% of Pharmaceutical composition gross weight, for example, account for 5%～15% of Pharmaceutical composition gross weight.For example, or for example, for the metformin hydrochloride of every 500 weight portions, the amount of disintegrating agent can be 5～50 weight portions, 10～25 weight portions.
According to the pharmaceutical composition of first aspect present invention any one, wherein, the amount of described binding agent can particularly easily be determined according to existing knowledge and experience when tablet in pharmaceutical compositions according to those skilled in the art.The amount of for example binding agent can be to account for 1%～20% of Pharmaceutical composition gross weight, for example, account for 1%～15% of Pharmaceutical composition gross weight, for example, account for 1%～10% of Pharmaceutical composition gross weight.The amount of for example binding agent can be to account for 1%～20% of granulation gross weight, for example, account for 1%～15% of granulation gross weight, for example, account for 1%～10% of granulation gross weight.For example, or for example, for the metformin hydrochloride of every 500 weight portions, the amount of binding agent can be 5～50 weight portions, 10～30 weight portions.
According to the pharmaceutical composition of first aspect present invention any one, wherein, the amount of described lubricant can particularly easily be determined according to existing knowledge and experience when tablet in pharmaceutical compositions according to those skilled in the art.The amount of for example lubricant can be to account for 0.1%～10% of Pharmaceutical composition gross weight, for example, account for 0.2%～5% of Pharmaceutical composition gross weight, for example, account for 0.2%～2.5% of Pharmaceutical composition gross weight.For example, or for example, for the metformin hydrochloride of every 500 weight portions, the amount of lubricant can be 2～20 weight portions, 3～15 weight portions.
According to the pharmaceutical composition of first aspect present invention any one, wherein, the amount of described filler can particularly easily be determined according to existing knowledge and experience when tablet in pharmaceutical compositions according to those skilled in the art, particularly can easily determine according to the needs of preparations shaping, for example, will usually determine according to size, the compression molding etc. of tablet.The amount of for example filler can be to account for 3%～30% of Pharmaceutical composition gross weight, for example, account for 5%～25% of Pharmaceutical composition gross weight, for example, account for 5%～20% of Pharmaceutical composition gross weight.For example, for example, or for example, for the metformin hydrochloride of every 500 weight portions, the amount of filler can be 15～150 weight portions, 25～125 weight portions, 50～100 weight portions.
According to the pharmaceutical composition of first aspect present invention any one, wherein, described " alkaline agent " represents conventional alkaline agent in medicine preparation.Being applicable to prepare the alkaline agent that comprises repaglinide pharmaceutical composition comprises at least harmless on physiology in dosage range used, be pharmaceutically useful many inorganic or organic bases, as sodium hydroxide solution, potassium hydroxide solution, ammonia, the tertiary sodium of phosphoric acid (tert-sodium phosphate), diethanolamine, ethylenediamine, N-METHYL-ALPHA-L-GLUCOSAMINE (being meglumine), 1B, trometamol etc.The mol ratio of active substance repaglinide and alkaline agent is preferably about 1:1.0 to 1:10, for example about 1:1.0 to 1:5, for example about 1:1.0 to 1:2.5, the amount of alkaline agent be 1～10 mole of repaglinide amount doubly, for example 1～5 mole times, for example 1～2.5 mole times.But more excessive alkali in some cases also may be favourable.Have been found that alkaline agent is useful for the stripping that promotes repaglinide.
According to the pharmaceutical composition of first aspect present invention any one, wherein, described term " solubilizing agent " represents conventional solubilizing agent in medicine preparation.Be applicable to the example of solubilizing agent that preparation comprises repaglinide pharmaceutical composition and comprise poloxamer, tween.In one embodiment, described alkaline agent poloxamer is PLURONICS F87.The character of solubilizing agent and ratio used are determining that aspect the dissolution rate of active substance be all important.The amount of solubilizing agent can particularly easily be determined according to existing knowledge and experience when tablet in pharmaceutical compositions according to those skilled in the art.For example, for the repaglinide of every 1 weight portion, the amount of solubilizing agent can be 0.1～10 weight portion, for example 0.1～5 weight portion, for example 0.1～2.5 weight portion, for example 0.1～0.5 weight portion.
According to the pharmaceutical composition of first aspect present invention any one, wherein, described filler is one or more in Icing Sugar, lactose, amylum pregelatinisatum, corn starch, microcrystalline Cellulose, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, Sorbitol, mannitol.
According to the pharmaceutical composition of first aspect present invention any one, wherein, described disintegrating agent is one or more of carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, sodium carboxymethyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpyrrolidone or low-substituted hydroxypropyl cellulose sodium, polacrilin potassium (polacrillin potassium is also called Po Lakelin potassium).
According to the pharmaceutical composition of first aspect present invention any one, wherein, described binding agent is one or more in water, polyvidone, ethanol, sodium carboxymethyl cellulose, polyvinylpyrrolidone or hypromellose.In the time that described binding agent is hypromellose, its alcoholic solution that is hypromellose, preferably 2.5% hypromellose alcoholic solution.In addition, in the situation that binding agent is water, it is essentially the wetting agent of granulation use, and it is removed in final granule.
According to the pharmaceutical composition of first aspect present invention any one, wherein, described lubricant is the one in magnesium stearate, Macrogol 4000-8000, micropowder silica gel, Pulvis Talci etc.
According to the pharmaceutical composition of first aspect present invention any one, wherein, described alkaline agent is selected from meglumine, trometamol.In one embodiment, described alkaline agent is trometamol.In one embodiment, described alkaline agent is trometamol, and described filler comprises calcium hydrogen phosphate.
According to the pharmaceutical composition of first aspect present invention any one, it is tablet or capsule.
According to the pharmaceutical composition of first aspect present invention any one, it is tablet.
According to the pharmaceutical composition of first aspect present invention any one, it is tablet, and it is further by coating.In one embodiment, described coating is film coating.
According to the pharmaceutical composition of first aspect present invention any one, it is unit dose formulations.
According to the pharmaceutical composition of first aspect present invention any one, it is unit dose formulations, in each unit dose formulations, the amount of repaglinide is 0.5～5.0mg, for example, be about 0.5mg, 1.0mg, 1.5mg, 2.0mg, 2.5mg, 3.0mg, 4.0mg, 5.0mg.
According to the pharmaceutical composition of first aspect present invention any one, it is unit dose formulations, and in each unit dose formulations, the amount of metformin hydrochloride is 100～1000mg, for example, be 400～600mg, for example, be about 400mg, 500mg, 600mg.
According to the pharmaceutical composition of first aspect present invention any one, it is unit dose formulations, and in each unit dose formulations, the amount of repaglinide is 0.5～5.0mg, and in each unit dose formulations, the amount of metformin hydrochloride is 400～600mg.
According to the pharmaceutical composition of first aspect present invention any one, it is unit dose formulations, and in each unit dose formulations, the amount of repaglinide is 1mg or 2mg, and in each unit dose formulations, the amount of metformin hydrochloride is 500mg.
Further, second aspect present invention provides the method for the pharmaceutical composition described in the arbitrary embodiment of for example first aspect present invention of pharmaceutical compositions, and the method comprises the following steps:
(a) each material is crushed to respectively to acceptable granularity in pharmacy (typically granularity is less than 80 orders);
(b) prepare granule I: by repaglinide and alkaline agent, solubilizing agent, (amount of for example binding agent can be to account for 1%～20% of granulation (preparing granule I) gross weight to appropriate binding agent, for example account for 1%～15% of granulation gross weight, for example account for granulation gross weight 1%～10%) be dissolved in appropriate water, make solution (in invention normally 1/4～3/4 of degree of reaching capacity concentration for most preferably, in test below the present invention, if not otherwise specified, all make the solution of 2/4 degree of saturation), by this spray solution, to appropriate filler, (its weight is for example 5-50 times of repaglinide, for example 5-25 doubly, for example 5-15 is doubly) in, fully mix homogeneously, be dried to moisture lower than 5% (for example, lower than 2.5%, particularly moisture is lower than 2%) granule, again this dried particles is ground to form to granularity and be less than the 80 orders fine powder of (being for example less than 100 orders), obtain granule I,
(c) prepare granule II: by metformin hydrochloride, remainder binder, (its weight is for example 0～20% of metformin hydrochloride weight to optional filler, for example 0～10%, for example 0～5%) and appropriate lubricant (its weight is for example 0～10% of metformin hydrochloride weight, for example 0～5%, for example 0～2.5%) mix homogeneously, water is wetting agent pelletize, dry, obtains granule II;
(d) whole mixed and preparations shaping: granule I, granule II, disintegrating agent, surplus lubricant and surplus filler are fully mixed, and the mixture obtaining is pharmaceutical composition of the present invention; Optionally this pharmaceutical composition packed in hard capsule case or be pressed into tablet, making the pharmaceutical composition of capsule or tablet.
According to the method for second aspect present invention any one, wherein, described tablet is further by coating.Coating material is well known to a person skilled in the art, it can be commercial especially, the coating material of the commodity Opadry by name being for example commercially available.The amount of tablet coating can be according to clothing material composition and easily definite, and for example, while using Opadry film coating, the amount of coating weightening finish can be 2-8%, for example, can be 2～6%.
According to the method for second aspect present invention any one, wherein, described in step (b), filler is calcium hydrogen phosphate.
According to the method for second aspect present invention any one, wherein, described in step (b), alkaline agent is trometamol.
Have been surprisingly found that and use trometamol to keep good stripping stability for alkaline agent not only can make compound medicament composition, and contributing to keep the chemical stability of preparation, the beneficial effect that this prior art is not instructed is completely beat all completely.Trometamol used can be the product that meets the quality standard of the 5.0 editions 2633 pages trometamol that record of European Pharmacopoeia (TROMETAMOL) in the present invention.
It is unit of association's dosage particles for pharmaceutical composition of the present invention, wherein preferably contain about 0.25 milligram to about 5 milligrams of repaglinides and about 200 milligrams to about 1200 milligrams of metformin or such as hydrochlorate of its salt.More preferably, this unit of association's dosage particles contain about 0.5 milligram to about 2.0 milligrams of repaglinides and about 500 milligrams to about 1000 milligrams of metformin or such as hydrochlorate of its salt.
In addition, preparation of the present invention shows and the basic similarly dissolution characteristic of the independent product of selling.
The dissolution characteristic of unit dose formulations of the present invention can be measured in simulated gastric fluid and in several aqueous solutions that are 1-7.5 in pH scope.Can use oar method (device 2 in USP, the device 1 in Ph.Eur.).The dissolving of repaglinide is strongly to rely on pH value.
Unit dose formulations of the present invention comprises repaglinide preformulation, metformin granule, filler, disintegrating agent and lubricant.
In another aspect of this invention, the method that provides treatment or prevention to need the patient's of this class treatment or prevention hyperglycemia, type 2 diabetes mellitus, impaired glucose tolerance, type 1 diabetes, obesity, hypertension, X syndrome, dyslipidemia, cognitive disorder, arteriosclerosis, myocardial infarction, coronary heart disease and other cardiovascular disorder, apoplexy, enteritis syndrome, dyspepsia and gastric ulcer, comprises this patient is used to the unit dosage forms of the present invention agent of stopping.
In another aspect of this invention, provide the method that delays or prevent the progression of disease of the patient's who needs this class treatment type 2 diabetes mellitus, comprised this patient is used to unit dosage forms preparation of the present invention.
In another aspect of this invention, provide and in the patient of this class treatment of needs, reduced food intake, reduction beta cell apoptosis, raising Instreptozotocin Induced and beta cell quality (mass), and/or the method for the glucose-sensitive of recovery to beta cell, comprise this patient is used to unit dosage forms preparation of the present invention.
With unit dosage forms preparation for treating of the present invention also can be for example selected from antidiabetic drug, anti-obesity medicine, appetite stimulator, antihypertensive, treat and/or prevent by diabetes and cause or the medicament of the complication relevant with diabetes and treating and/or preventing by obesity causes or second or more pharmaceutically active substance of the medicament of the complication relevant with obesity and deficiency disorder are combined.
In one embodiment, unit dosage forms preparation of the present invention is for the preparation for the treatment of or the prophylactic agent of hyperglycemia, type 2 diabetes mellitus, impaired glucose tolerance, type 1 diabetes, obesity, hypertension, X syndrome, dyslipidemia, cognitive disorder, arteriosclerosis, myocardial infarction, apoplexy, coronary heart disease and other cardiovascular disorder, enteritis syndrome, dyspepsia and gastric ulcer.
In another embodiment, unit dosage forms preparation of the present invention is for the preparation of the medicine that delays or prevent the progression of disease of type 2 diabetes mellitus to use.
Term used herein " disease treatment " refers to the patient's that this disease, symptom or deficiency disorder occur management and nursing.Therapeutic purposes are antagonism this disease, symptom or deficiency disorders.Treatment comprises uses reactive compound to eliminate or to control this disease, symptom or deficiency disorder, and alleviates the symptom relevant with this disease, symptom or deficiency disorder or complication.
Term used herein " disease prevention " referred to before the clinical episodes of this disease having dangerous individual management and nursing that this disease occurs.Prevention object is that the development comprising of antagonism this disease, symptom or deficiency disorder is used reactive compound with prevention or delays outbreak and the prevention of symptom or complication or delay the development of relevant disease, symptom or deficiency disorder.
Arbitrary technical characterictic that arbitrary embodiment of either side of the present invention or this either side has is suitable for arbitrary embodiment of other arbitrary embodiment or other either side equally, as long as they can be not conflicting, certainly, at where applicable each other, necessary words can be done suitably to modify to individual features.Be further described with feature to various aspects of the present invention below.
All documents that the present invention quotes from, their full content is incorporated to herein by reference, and if when the expressed implication of these documents and the present invention are inconsistent, be as the criterion with statement of the present invention.In addition, various terms and phrase that the present invention uses have the general sense of well known to a person skilled in the art, nonetheless, the present invention still wishes at this, these terms and phrase to be described in more detail and to be explained, the term of mentioning and phrase, if any inconsistent with known implication, are as the criterion with the implication that the present invention was explained.
One of active component of the present invention repaglinide is almost insoluble in water, dissolubility in water is only 0.005mg/mL, not only cause vitro Drug dissolution poor, cause its bioavailability low, and because metformin is water soluble drug, can cause metformin rate of releasing drug suitable if therefore adopt conventional technique to carry out tabletting, repaglinide will can not discharge out.And repaglinide rate of releasing drug is suitable, will loses control of the release of metformin, and cause the prominent of metformin hydrochloride to be released.Prior art adopts to be improved the method for technique and solves the problems referred to above, as CN101843617A adopts the method that repaglinide, metformin hydrochloride is adopted respectively different framework materials to be pressed into double-layer sustained release tablets to become to be pressed into respectively small pieces.But the method is too high to equipment requirements, be difficult to suitability for industrialized production, and double-layer sustained release tablets can cause tablet hardness excessive in preparation process, affect drug release, Dual-layer sheet joint face is difficult to discharge medicine.
Medicine in vivo infiltration rate is usually determined by the speed dissolving, medicine in solid preparation is before being absorbed, must and dissolve the process that then transfers solution to through disintegrate, if medicine is difficult for discharging from preparation or the dissolution velocity of medicine is very slow, the infiltration rate of said preparation Chinese medicine or degree just likely have problems, on the other hand, some pharmacological action is violent, safety index is little, if absorbed, medicine dissolution rate is too fast rapidly, may produce obvious untoward reaction, the time that maintains drug effect also will shorten, in this case, the dissolution rate of preparation of Chinese medicine be should give control.In the present invention, repaglinide is water-soluble hardly, and metformin is water-soluble, can exist metformin dissolution rate suitable if therefore adopt common repaglinide and metformin and pharmaceutic adjuvant to make common tablet, repaglinide is just difficult for discharging from compound preparation; And repaglinide dissolution rate is suitable, metformin is will dissolution rate too fast.The present invention finds the tablet that uses formula of the present invention to make, and two kinds of active medicines all have good dissolving out capability in acid and neutral dissolution medium, and all have good stripping stability; In addition, the inventive method is simple, (this complex apparatus is very obvious for drug loss not need to use for example spray-dired complex apparatus, for example the inventive method step (b) is prepared granule I, the yield (being that the amount of repaglinide in granule I is divided by repaglinide inventory gained percent) of its active component repaglinide reaches more than 95%, shows that drug loss amount is fewer; But with reference to CN101516347A (Chinese Patent Application No. 200780036006.2, Nuo Wo-Nuo Disike) " the repaglinide trituration " described in the method Preparation Example 2 of embodiment 3, the yield of repaglinide is only 76%, shows relatively large active component and loses because of preparation technology).
In some examples of the present invention, repaglinide is prepared granule with described with described alkaline agent together with the calcium hydrogen phosphate of filler.
In some examples of the present invention, gained compound tablet is carried out to coating.The coating material that coating is used is thin film coating material Opadry, and 1000 compound Repaglinide/diformin tablets of the present invention (the about 500mg of hydrochloric metformin) are approximately used 5.5g Opadry coating powder (Opadry).
Specifically, art for coating comprises preparation and two steps of coating of film-coat solution, and these two its techniques of step are as follows:
The preparation of film-coat solution: the purified water that takes recipe quantity is put in agitator tank, opens stirring and makes liquid level just form whirlpool, and the Opadry powder of recipe quantity is at the uniform velocity added in whirlpool, after reinforced, adjust mixing speed whirlpool is just disappeared, continue to stir 45 minutes, for subsequent use.
Coating: get plain chip and put in coating pan, open compressed air, start seed-coating machine, coating pan is slowly rotated, and preheating label to approximately 40 DEG C time, is opened spray gun, coating solution is sprayed onto on the label of rotation, spraying is dried with the hot blast relaxing simultaneously, complete to coating solution spraying, continues blowing hot-air and makes coating solvent evaporates dry.
Prepared a kind of of the present invention has following one or more advantages by repaglinide and metformin as Pharmaceutical composition and the described preparation method of active ingredient: (1) prescription rationally, adjuvant used is safe and reliable, has greatly improved patient's drug safety; (2) obtained label outward appearance is good, has better dissolving out capability simultaneously; (3) steady quality, is difficult for decomposing and goes bad, and also can not jolt tablet is produced and destroyed because of transport; (4) described compositions disintegrate dispersion rapidly fast, makes medicine dispersed, and digestive tract local drug concentration is unlikely to too high, thereby has avoided the stimulation causing because local drug concentration is too high; (5) Pharmaceutical composition provided by the present invention can be realized the object of synchronous release, and In Vitro Dissolution is good, and its bioavailability is high.
Detailed description of the invention
Further illustrate the present invention below by specific embodiment/experimental example, still, should be understood to, these embodiment and experimental example are only used for the use specifically describing more in detail, and should not be construed as for limiting in any form the present invention.
The present invention carries out generality and/or concrete description to the material and the test method that use in test.Although be well known in the art for realizing many materials and the operational approach that the object of the invention uses, the present invention still does to describe in detail as far as possible at this.It will be apparent to those skilled in the art that hereinafter, if not specified, material therefor of the present invention and operational approach are well known in the art.
In the time that the present invention below prepares tablet, the amount that comprises metformin hydrochloride in every is 500mg; And the amount of repaglinide can be easily by carrying out two kinds of granules while mixing in second aspect present invention step (d), adjust the amount of granule I so that the amount of every middle repaglinide is adjusted into 1mg or 2mg; Below in example if no special instructions, the amount that comprises repaglinide in every is adjusted into 2mg.In addition, the feed intake amount of the metformin hydrochloride that comprises of every batch of material is 500g, and every batch of material inventory is the amount of 1000 of preparations, although show with the scale of each component in every while listing formula in example below.
In the time below carrying out test chemical, for example, when the content to metformin or repaglinide in the compositions of preparation, dissolution, related substance check, can use the detection method of these two kind single preparationss of ephedrine, for example can use metformin hydrochloride raw material that two of version Chinese Pharmacopoeias in 2010 record and the method for preparation to carry out for metformin, can use repaglinide raw material that two of version Chinese Pharmacopoeias in 2010 record and the method for preparation to carry out for repaglinide.These methods are applicable to compound tablet and are unlikely the wherein mensuration of another component of components influence (deducting the chromatographic peak that another active substance produces in the time measuring the related substance of certain active component), for example, while using repaglinide determination of related substances to measure related substance, can not be affected because of the existence assay method of metformin.
embodiment part: the pharmaceutical composition that preparation comprises metformin and repaglinide
embodiment 1: pharmaceutical compositions
Formula:
In upper table, the amount of trometamol is 1.87 moles of repaglinide doubly (while calculating the two relative quantity below all with mole doubly represent).
Method for making:
(a) each material is crushed to respectively to acceptable granularity in pharmacy (granularity is less than 80 orders);
(b) prepare granule I: repaglinide and alkaline agent, solubilizing agent, binding agent are dissolved in to the solution of making 2/4 degree of saturation in appropriate water, by this spray solution, (exit is through the syringe of repacking, while outwards extruding, solution can therefrom spray) in filler, fully mix homogeneously, be dried to moisture lower than 2% granule, again this dried particles is ground to form to granularity and be less than 80 object fine powders, obtain granule I (in this technique, the repaglinide yield of granule I is 96.3%);
(c) prepare granule II: by even to metformin hydrochloride, binding agent, filler and mix lubricant, water is wetting agent pelletize, is dried to moisture lower than 2%, obtains granule II;
(d) whole mixed and preparations shaping: granule I, granule II, disintegrating agent, lubricant and filler are fully mixed, and the mixture obtaining is pharmaceutical composition of the present invention.Said composition 1/3 directly packs in hard gelatin capsule with powder/granule, every hydrochloric metformin 500mg; Other 2/3 is pressed into tablet, every hydrochloric metformin 500mg; This tablet is designated as Ex1, uses aluminum-plastic composite membrane bag hermetic package, must be the pharmaceutical composition of the present invention (plain sheet) of tablet, and it is investigated for test below.
(e) further,, by step (d) gained part tablet Opadry coating, every is wrapped up clothing material 15mg (increasing weight approximately 2.42%), obtains being the pharmaceutical composition of the present invention of Film coated tablets.
Additional embodiment 1: with reference to formula and the method for above-described embodiment 1, different is regulates the amount of trometamol wherein, be respectively 0,0.2,0.5,0.75,1.0,1.5,2.0,3.0,4.0,5.0,6.0,8.0,12.0 or 20.0 mole of repaglinide doubly, the plain sheet obtaining is designated as respectively Ex101, Ex102, Ex103, Ex104, Ex105, Ex106, Ex107, Ex108, Ex109, Ex110, Ex111, Ex112, Ex113, Ex114, uses respectively aluminum-plastic composite membrane bag hermetic package.
Additional embodiment 2: with reference to formula and the method for above-described embodiment 1, different is regulates the amount of calcium hydrogen phosphate wherein, respectively 0,1,2.5,5,7.5,12.5,15,20,30,50 times of weight of repaglinide, the plain sheet obtaining is designated as respectively Ex121, Ex122, Ex123, Ex124, Ex125, Ex126, Ex127, Ex128, Ex129 and Ex130, uses respectively aluminum-plastic composite membrane bag hermetic package.
Additional embodiment 3: with reference to formula and the method for above-described embodiment 1, different is that wherein trometamol replaces with meglumine, and its amount is respectively 0.5,1.0,2.0,5.0,10.0 mole times of repaglinide, the plain sheet obtaining is designated as respectively Ex131, Ex132, Ex133, Ex134, Ex135, uses respectively aluminum-plastic composite membrane bag hermetic package.
Additional embodiment 4: with reference to formula and the method for above-described embodiment 1, different is that wherein trometamol replaces with 1B, and its amount is respectively 0.5,1.0,2.0,5.0,10.0 mole times of repaglinide, the plain sheet obtaining is designated as respectively Ex136, Ex137, Ex138, Ex139, Ex140, uses respectively aluminum-plastic composite membrane bag hermetic package.
Additional embodiment 5: with reference to formula and the method for above-described embodiment 1, different calcium hydrogen phosphate is wherein replaced with respectively to equivalent: calcium phosphate, microcrystalline Cellulose, calcium sulfate, carboxymethyl starch sodium or silicon dioxide, the plain sheet obtaining is designated as respectively Ex141, Ex142, Ex143, Ex144, Ex145, uses respectively aluminum-plastic composite membrane bag hermetic package.
With reference to CN101516347A (Chinese Patent Application No. 200780036006.2, Nuo Wo-Nuo Disike) formula of description embodiment 2 and the method for making of embodiment 3, the plain sheet obtaining is designated as Ex151, with aluminum-plastic composite membrane bag hermetic package (while using spray drying method preparation " repaglinide trituration ", repaglinide yield is 76.2%).
With reference to formula and the method for making of CN101756971A (Chinese Patent Application No. 200810224002.3, German public is perfectly sound) embodiment 2, the plain sheet obtaining is designated as Ex152, uses aluminum-plastic composite membrane bag hermetic package.
With reference to CN102218064A (Chinese Patent Application No. 201110100196.8, Hainan brocade is auspicious) formula and the method for making of description example of formulations 5, and with the repaglinide that wherein embodiment 4 methods make be raw material, the plain sheet obtaining is designated as Ex153, uses aluminum-plastic composite membrane bag hermetic package.
With reference to formula and the method for CN102319245A (Chinese Patent Application No. 201110190175.X) description embodiment 1, the plain sheet obtaining is designated as Ex154, uses aluminum-plastic composite membrane bag hermetic package.
With reference to formula and the method for CN103070864A (Chinese Patent Application No. 201210518601.2) description embodiment 3, the plain sheet obtaining is designated as Ex155, uses aluminum-plastic composite membrane bag hermetic package.
embodiment 201: prepare pharmaceutical composition of the present invention
With reference to formula and the method for above-described embodiment 1, different is when " (d) whole mixed and preparations shaping ", the amount of granule I reduces by half, change 12mg into, make the tablet containing repaglinide 1mg/ metformin hydrochloride 500mg, the plain sheet obtaining is designated as Ex201, uses aluminum-plastic composite membrane bag hermetic package.
embodiment 202: prepare pharmaceutical composition of the present invention
Formula:
With reference to the method for above-described embodiment 1, the plain sheet obtaining is designated as Ex202, uses aluminum-plastic composite membrane bag hermetic package.
embodiment 203: prepare pharmaceutical composition of the present invention
Formula:
With reference to the method for above-described embodiment 1, the plain sheet obtaining is designated as Ex203, uses aluminum-plastic composite membrane bag hermetic package.
embodiment 204: prepare pharmaceutical composition of the present invention
Formula:
With reference to the method for above-described embodiment 1, the plain sheet obtaining is designated as Ex204, uses aluminum-plastic composite membrane bag hermetic package.
embodiment 205: prepare pharmaceutical composition of the present invention
Formula with embodiment 1, but preparation method with reference to CN103070864A description to section method carry out, the plain sheet obtaining is designated as Ex205, uses aluminum-plastic composite membrane bag hermetic package.
embodiment 206: prepare pharmaceutical composition of the present invention
Formula is with embodiment 1, but preparation method carries out with reference to the method for CN102319245A description embodiment 1, and the plain sheet obtaining is designated as Ex206, uses aluminum-plastic composite membrane bag hermetic package.
test example part: to the tablet medicine that comprises metformin and repaglinide that above embodiment part prepares
compositions is carried out pharmaceutical property detection
test example 1: the Performance of pharmaceutical composition---Dissolution Rate Testing
1, the dissolution in acid medium is investigated: get the tablet medicine compositions that comprises two kinds of components that above each embodiment prepares, carry out according to the second method (oar method) in two annex XC dissolution methods of Chinese Pharmacopoeia version in 2010.Dissolution medium is the hydrochloric acid solution 900ml of 0.1mol/L, and rotating speed 50rpm, in the wherein dissolution of two kinds of combinations of 20 minutes sampling and measuring.
2, the dissolution in neutral medium is investigated: get the tablet medicine compositions that comprises two kinds of components that above each embodiment prepares, carry out according to the second method (oar method) in two annex XC dissolution methods of Chinese Pharmacopoeia version in 2010.Dissolution medium is potassium dihydrogen phosphate (phosphoric acid or potassium hydroxide regulate pH to the 6.8) 900ml of 0.2mol/L, and rotating speed 50rpm, in the wherein dissolution of two kinds of combinations of 20 minutes sampling and measuring.
3, result: whole tablets that above embodiment part prepares, in acid and neutral two media, the dissolution of metformin all, in 94～101% scopes, shows that metformin has good dissolving out capability.For example the dissolution of Ex1 tablet metformin in acid and neutral two media is respectively 97.6% and 95.3%.
Whole tablets that above embodiment part prepares, in acid and neutral two media, the dissolution of repaglinide all, in 75～98% scopes, shows that repaglinide has good dissolving out capability (stripping of version pharmacopeia repaglinide kind 45min in 2010 is defined as 75%).Particularly Ex1, Ex105, Ex106, Ex107, Ex108, Ex109, Ex110, Ex124, Ex125, Ex126, Ex127, Ex201, Ex202, Ex203, Ex204, Ex205, Ex206 these there is the compositions of feature of the present invention, in acid and neutral two media, the dissolution of repaglinide is all in 88～98% scopes.For example the dissolution of Ex1 tablet metformin in acid and neutral two media is respectively 93.1% and 90.6%.
test example 2: the Performance of pharmaceutical composition---dissolving out capability study on the stability
Accelerated test method: by whole tablets that above embodiment part prepares, use aluminum-plastic composite membrane bag hermetic package, be placed under 45 ° of C conditions and place May (can be called for short below " 45 ° of C-5 months ", " May ", " high-temperature treatment " or " high-temperature treatment May "), measure the dissolution (dissolution determination method referring to test example 1) of each sample after this high-temperature treatment, and the dissolution 0 month time compares with respective samples, calculate the dissolution percent change that can be used for characterizing tablet dissolving out capability stability with following formula:
Dissolution percent change more shows that close to 100% the stability of sample dissolution performance after high-temperature treatment May is better.
Result shows, whole tablets that above embodiment part prepares, and in acid and neutral two media, the dissolution percent change of metformin all, in 95～105% scopes, shows that metformin has good stripping stability.For example the dissolution percent change of Ex1 tablet metformin in acid and neutral two media is respectively 101.6% and 99.6%.
Whole tablets that above embodiment part prepares, in acid and neutral two media, the dissolution percent change of repaglinide demonstrates different situations of change.For Ex1, Ex105, Ex106, Ex107, Ex108, Ex109, Ex110, Ex124, Ex125, Ex126, Ex127, Ex201, Ex202, Ex203, Ex204, Ex205, Ex206, their dissolution percent change in acid medium are all in 94～102% scopes, their dissolution percent change in neutral medium are all in 95～103% scopes, show that these samples all have good dissolution stability, for example the dissolution percent change of Ex1 tablet repaglinide in acid and neutral two media is respectively 97.8% and 99.5%.
For Ex101, Ex102, these samples of Ex103, Ex104, their dissolution percent change in acid medium are all in 72～84% scopes, their dissolution percent change in neutral medium all, in 69～83% scopes, show that the dissolution of these samples in two media all has bad stability.For Ex111, Ex112, these samples of Ex113, Ex114, their dissolution percent change in acid medium are all in 92～99% scopes, their dissolution percent change in neutral medium are all in 71～84% scopes, show that the dissolution of these samples in acid medium has good stability, but after trometamol consumption is excessive, dissolution stability in neutral medium can not be satisfactory, shows that the measurer of trometamol has the specific range of choice in the present composition.
For Ex121, Ex122, these samples of Ex123, their dissolution percent change in acid medium are all in 73～86% scopes, their dissolution percent change in neutral medium all, in 70～84% scopes, show that the dissolution of these samples in two media all has bad stability.For Ex128, Ex129, these samples of Ex130, their dissolution percent change in acid medium are all in 68～80% scopes, their dissolution percent change in neutral medium are all in 87～95% scopes, show the dissolution poor stability of these samples in acid medium, but after calcium hydrogen phosphate consumption is excessive, dissolution stability in acid medium can not be satisfactory, shows that the measurer of calcium hydrogen phosphate has the specific range of choice in the present composition.
For Ex131, Ex132, Ex133, Ex134, Ex135, Ex136, Ex137, Ex138, these samples of Ex139, Ex140, their dissolution percent change in acid medium are all in 67～85% scopes, their dissolution percent change in neutral medium all, in 88～95% scopes, show the dissolution poor stability of these samples in acid medium.Show not use trometamol and use other alkaline agent instead and can not ensure that the dissolving out capability of tablet in acid and neutral medium stablize.
For Ex141, Ex142, Ex143, Ex144, Ex145, these do not use the sample of calcium hydrogen phosphate, their dissolution percent change in acid medium are all in 71～84% scopes, their dissolution percent change in neutral medium all, in 73～83% scopes, show that the dissolution of these samples in two media all has bad stability.
For Ex151, Ex152, Ex153, Ex154, Ex155, these do not have the sample of feature of the present invention, their dissolution percent change in acid medium are all in 73～87% scopes, their dissolution percent change in neutral medium all, in 68～85% scopes, show that the dissolution of these samples in two media all has bad stability.
test example 3: the Performance of pharmaceutical composition---related substance inspection
Get the tablet medicine compositions that comprises two kinds of components that above each embodiment prepares, method in repaglinide raw material and the tablet recording according to Chinese Pharmacopoeia two of versions in 2010, measures total related substance in the present invention's tablet medicine compositions that each embodiment prepares above.Folk prescription tablet in pharmacopeia specifies that total related substance should be less than 1.5%.
After measured, the tablet medicine compositions that what the various embodiments described above prepared comprise two kinds of components, is used repaglinide determination of related substances method, and the amount that result shows total related substance is all in 0.15～0.55% scope, and total related substance of for example Ex1 is 0.23%.
test example 4: the Performance of pharmaceutical composition---related substance study on the stability
Accelerated test method: by whole tablets that above embodiment part prepares, use aluminum-plastic composite membrane bag hermetic package, be placed under 45 ° of C conditions and place May (can be called for short below " 45 ° of C-5 months ", " May ", " high-temperature treatment " or " high-temperature treatment May "), measure the total related substance of each sample after this high-temperature treatment, and the total related substance 0 month time compares with respective samples, calculate the total related substance percent change that can be used for characterizing tablet chemistry stability with following formula:
Total related substance percent change more shows that close to 100% the stability of sample chemical property after high-temperature treatment May is better.
Whole tablets that above embodiment part prepares, total related substance percent change of repaglinide demonstrates different situations of change.For Ex1, Ex105, Ex106, Ex107, Ex108, Ex109, Ex110, Ex124, Ex125, Ex126, Ex127, Ex201, Ex202, Ex203, Ex204, Ex205, Ex206, their total related substance percent change is all in 97～121% scopes, total related substance percent change of for example Ex1 is 112%, while showing these samples with respect to 0 month, be not significantly increased through 5 months rear impurities of high-temperature process.
For Ex101, Ex102, these samples of Ex103, Ex104, their total related substance percent change is all in 175～245% scopes, and the fewer percent change of trometamol consumption is larger.For Ex111, Ex112, these samples of Ex113, Ex114, their total related substance percent change is all in 165～230% scopes, and the larger percent change of trometamol consumption is larger.For Ex131, Ex132, Ex133, Ex134, Ex135 and Ex136, Ex137, Ex138, Ex139, Ex140, these do not use the sample of trometamol, and their total related substance percent change is all in 150～220% scopes.For Ex151, Ex152, Ex153, Ex154, Ex155, these do not use the sample of trometamol, and their total related substance percent change is all in 165～230% scopes.Visible, comprise appropriate amounts of ammonia butantriol for the chemical stability of tablet particularly the chemical stability of repaglinide be useful.
test example 5: the Performance of pharmaceutical composition---the uniformity of dosage units of repaglinide in tablet
With reference to the Determination of Content Uniformity method in two repaglinides that record of version Chinese Pharmacopoeia in 2010, measure the uniformity of dosage units of repaglinide in Ex1, Ex105, Ex106, Ex107, Ex108, Ex109, Ex110, Ex124, Ex125, Ex126, Ex127, Ex201, Ex202, Ex203, Ex204, Ex205, these tablets of Ex206, result shows that the A+1.80S value of these samples is all less than 12.0 (pharmacopeia regulation should A+1.80S≤15.0), the A+1.80S=8.7 of for example Ex1.Show that the present invention uses better simply method to obtain the good tablet content uniformity.
Claims (5)
1. a tablet, its formula of every consists of:
Wherein, consisting of of granule I:
Granule II consists of:
The method for making of this tablet is:
(a) each material is crushed to respectively to granularity and is less than 80 orders;
(b) prepare granule I: repaglinide and trometamol, PLURONICS F87,30 POVIDONE K 30 BP/USP 25 are dissolved in to the solution of making 2/4 degree of saturation in appropriate water, by this spray solution in calcium hydrogen phosphate, fully mix homogeneously, be dried to moisture lower than 2% granule, again this dried particles is ground to form to granularity and be less than 80 object fine powders, obtain granule I;
(c) prepare granule II: by metformin hydrochloride, 30 POVIDONE K 30 BP/USP 25, Sorbitol and polyethylene glycol 6000 mix homogeneously, water is wetting agent pelletize, is dried to moisture lower than 2%, obtains granule II;
(d) whole mixed and preparations shaping: granule I, granule II, polacrilin potassium, magnesium stearate and microcrystalline Cellulose are fully mixed, and the mixture obtaining is pressed into tablet, every hydrochloric metformin 500mg.
2. a tablet, its formula of every consists of:
Wherein, consisting of of granule I:
Granule II consists of:
The method for making of this tablet is:
(a) each material is crushed to respectively to granularity and is less than 80 orders;
(b) prepare granule I: repaglinide and trometamol, PLURONICS F87,30 POVIDONE K 30 BP/USP 25 are dissolved in to the solution of making 2/4 degree of saturation in appropriate water, by this spray solution in calcium hydrogen phosphate, fully mix homogeneously, be dried to moisture lower than 2% granule, again this dried particles is ground to form to granularity and be less than 80 object fine powders, obtain granule I;
(c) prepare granule II: by metformin hydrochloride, 30 POVIDONE K 30 BP/USP 25, Sorbitol and polyethylene glycol 6000 mix homogeneously, water is wetting agent pelletize, is dried to moisture lower than 2%, obtains granule II;
(d) whole mixed and preparations shaping: granule I, granule II, polacrilin potassium, magnesium stearate and microcrystalline Cellulose are fully mixed, and the mixture obtaining is pressed into tablet, every hydrochloric metformin 500mg.
3. a tablet, its formula of every consists of:
Wherein, consisting of of granule I:
Granule II consists of:
The method for making of this tablet is:
(a) each material is crushed to respectively to granularity and is less than 80 orders;
(b) prepare granule I: repaglinide and trometamol, Tween 80, PVP K30 are dissolved in to the solution of making 2/4 degree of saturation in appropriate water, by this spray solution in calcium hydrogen phosphate, fully mix homogeneously, be dried to moisture lower than 2% granule, again this dried particles is ground to form to granularity and be less than 80 object fine powders, obtain granule I;
(c) prepare granule II: by metformin hydrochloride, hypromellose, microcrystalline Cellulose and magnesium stearate mix homogeneously, water is wetting agent pelletize, is dried to moisture lower than 2%, obtains granule II;
(d) whole mixed and preparations shaping: granule I, granule II, polacrilin potassium, polyethylene glycol 6000 and corn starch are fully mixed, and the mixture obtaining is pressed into tablet, every hydrochloric metformin 500mg.
4. a tablet, its formula of every consists of:
Wherein, consisting of of granule I:
Granule II consists of:
The method for making of this tablet is:
(a) each material is crushed to respectively to granularity and is less than 80 orders;
(b) prepare granule I: repaglinide and trometamol, Tween 80, PVP K30 are dissolved in to the solution of making 2/4 degree of saturation in appropriate water, by this spray solution in calcium hydrogen phosphate, fully mix homogeneously, be dried to moisture lower than 2% granule, again this dried particles is ground to form to granularity and be less than 80 object fine powders, obtain granule I;
(c) prepare granule II: by metformin hydrochloride, hypromellose, amylum pregelatinisatum mix homogeneously, water is wetting agent pelletize, is dried to moisture lower than 2%, obtains granule II;
(d) whole mixed and preparations shaping: granule I, granule II, polacrilin potassium, Pulvis Talci and microcrystalline Cellulose are fully mixed, and the mixture obtaining is pressed into tablet, every hydrochloric metformin 500mg.
5. a tablet, its formula of every consists of:
Wherein, consisting of of granule I:
Granule II consists of:
The method for making of this tablet is:
(a) each material is crushed to respectively to granularity and is less than 80 orders;
(b) prepare granule I: repaglinide and trometamol, Tween 80, PVP K30 are dissolved in to the solution of making 2/4 degree of saturation in appropriate water, by this spray solution in calcium hydrogen phosphate, fully mix homogeneously, be dried to moisture lower than 2% granule, again this dried particles is ground to form to granularity and be less than 80 object fine powders, obtain granule I;
(c) prepare granule II: by metformin hydrochloride, hypromellose, sucrose starch, magnesium stearate mix homogeneously, water is wetting agent pelletize, is dried to moisture lower than 2%, obtains granule II;
(d) whole mixed and preparations shaping: granule I, granule II, polacrilin potassium, Pulvis Talci and microcrystalline Cellulose are fully mixed, and the mixture obtaining is pressed into tablet, every hydrochloric metformin 500mg.
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| CN106109428B (en) * | 2016-07-22 | 2019-06-21 | 江苏豪森药业集团有限公司 | The preparation process of Repaglinide melbine |
| CN106176718A (en) * | 2016-08-03 | 2016-12-07 | 上海延安药业有限公司 | Compound recipe canagliflozin diformin tablet |
| CN115154432B (en) * | 2022-07-22 | 2023-03-24 | 北京惠之衡生物科技有限公司 | Repaglinide tablet and preparation method thereof |
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