CN103242779B - Biological intelligent glue - Google Patents
Biological intelligent glue Download PDFInfo
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- CN103242779B CN103242779B CN201310174037.1A CN201310174037A CN103242779B CN 103242779 B CN103242779 B CN 103242779B CN 201310174037 A CN201310174037 A CN 201310174037A CN 103242779 B CN103242779 B CN 103242779B
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- biological intelligent
- intelligent glue
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Abstract
The invention discloses a kind of biological intelligent glue. The biological intelligent glue disclosed by the invention is prepared from sodium alga acid, chitosan, polyvinyl alcohol, glycerin, carbomer, N, N-methylene bisacrylamide, and dimethyl 2,2'-azobis(2-methylpropionate) in a weight ratio. The biological intelligent glue disclosed by the invention is strong in electrical conductivity, small in electrical resistivity, and biodegradable; and when the biological intelligent glue is used as a gluing and conductive medium for manufacturing a disposable electrocardiograph monitoring electrode, the biological intelligent glue disclosed by the invention is not dried and good in adhesion, and can keep in good contact with the skin for a long time, therefore, the electrode interference is less, the electrode potential is stable, and the electrocardiograph waveform is clear and stable; the biological intelligent glue can be adhered without residues and has no stimulation to the skin; and the biological intelligent glue is low in production cost and high in environmental performance, and has extremely practicability and popularization values.
Description
Technical field
The present invention relates to a kind of Biological intelligent glue, particularly relate to that a kind of electroconductibility is strong, under resistivity, can the Biological intelligent glue of microbiological deterioration.
Background technology
At present, disposable electrocardiographicmonitoring monitoring electrode mainly coordinates the use such as electrocardiograph, patient monitor, accept human ECG, for monitoring the information such as heart rate, pulse of patient, a kind of important and conventional bio-medical sensor, because having feature that is easy to use, cross infection of need not sterilizing, can avoid.
The conducting wire that disposable electrocardiographicmonitoring monitoring electrode mainly comprises electrode body, electrode plug terminal and is connected electrically between electrode body and electrode plug terminal, electrode body is generally made up of non-woven fabrics, separate-type paper, hydrogel.Existing disposable electro cardiscope monitor has following shortcoming: the colloid Area comparison of electrode body is little, therefore contact skin is also smaller, and conductivity is general; Sticker is used long afterwards can be dry, and tackiness is not fine, is easily shifted after patient perspires; Because non-woven fabrics is with non-setting adhesive, so have minimal irritation with irritated to skin, also have some gerontal patients settle for a long time disposable electro cardiscope monitor as easy as rolling off a log occur electrode slice paste position damage in various degree, as local hemorrhage, itch even on erythema basis, papule, blister occur, coming in contact property dermatitis; Complicated operation, pasting skin has a little pain with when peeling off skin; Production cost is high, duration of service is short, the hydrogel environmental-protecting performance difference etc. adopted.
Due to the existence of above-mentioned shortcoming, the performance of existing disposable electrocardiographicmonitoring monitoring electrode is mostly not satisfactory, do not catch up with the demand of medical monitoring equipment development with rapid changepl. never-ending changes and improvements, electrode interference is many, noise is high, ecg wave form is unintelligible and poor stability directly affects the Accurate Diagnosis of medical personnel to disease.
Summary of the invention
The object of the invention is to the deficiency overcoming existing disposable electrocardiographicmonitoring monitoring electrode existence, a kind of Biological intelligent glue is provided, it has, and its electroconductibility is strong, resistivity is little, biodegradable feature, this Biological intelligent glue is adopted to manufacture disposable electrocardiographicmonitoring monitoring electrode, this Biological intelligent glue can not be dry, long-time and skin can keep good contact, adhibit quality is very good, noresidue, feature non-stimulated to skin, interference is few, the electropotential obtained is stablized, and ecg wave form is steady and audible, easy to operate, production cost is low.
The technical solution adopted in the present invention is: a kind of Biological intelligent glue, be made up of the raw material of following weight proportion: sodium alginate 8-20%, chitosan 6-16%, polyvinyl alcohol 35-45%, glycerine 16-25%, carbomer 10-20%, N,N methylene bis acrylamide 1-3%, azo-bis-iso-dimethyl 0.5-2%.
Biological intelligent glue preparation method of the present invention is following concrete steps:
(1) following raw material is got by weight ratio: sodium alginate 8-20%, chitosan 6-16%, polyvinyl alcohol 35-45%, glycerine 16-25%, carbomer 10-20%, N, N-methylene-bisacrylamide 1-3%, azo-bis-iso-dimethyl 0.5-2%, sequentially the sodium alginate of above-mentioned taking-up, chitosan, polyvinyl alcohol, glycerine, carbomer are put into agitator, room temperature be 14-16 DEG C, under humidity is the environment of 18-25%, after stirring 7-9 hour with the stirrer of 600-800 rev/min of rotating speed, stop stirrer, make the temperature of the liquid of acquisition be down to 14-16 DEG C;
(2) restart stirrer, stir 4-6 hour with the rotating speed of 800-900 rev/min, then add N, N-methylene-bisacrylamide 1-3%, continue to stir 2-5 hour, then add azo-bis-iso-dimethyl 0.5-2%, continue to stir stopping after 3-5 hour and stir;
(3) raw material be stirred that step (2) obtains is placed in room temperature is 14-16 DEG C, humidity is leave standstill de-bubble 7-9 hour under the environment of 18-25%;
(4) after leaving standstill end, start glue making machine, curing setting is temperature required, heat up, load onto polyethylene terephthalate (PET) glued membrane, load onto the blue film of PET, load onto arteries and veins silk, adjust all deviation-rectifying systems, it is synchronous with the radix of winder that the radix taking out glue pump is set, opens the air intake filter of machine, after infrared rays curing temperature reaches 140-180 DEG C, open machine exhaust system, then press the automatic button of machine, can Biological intelligent glue be produced.
Compared with prior art, the present invention has following beneficial effect:
(1) Biological intelligent glue electroconductibility of the present invention is strong, resistivity is little (128 ohm-sq centimetre), can under the effect of the microorganisms such as bacterium, mould, algae, there is biochemical reaction, the mould each side such as inner quality change that change to of self outward appearance are caused to change, the compound of the common forms of nature such as final formation carbonic acid gas and water, can not pollute soil and underground water etc., environmental-protecting performance is high; (2) adopt Biological intelligent glue of the present invention as the medium of the gluing of disposable electrocardiographicmonitoring monitoring electrode with conduction, for the manufacture of disposable electrocardiographicmonitoring monitoring electrode, Biological intelligent glue can not be dry, long-time and skin can keep good contact, thus make electrode interference few, electropotential is stablized, and ecg wave form is steady and audible; The adhibit quality of Biological intelligent glue is very good, even if residual and patient perspires and also can not be shifted, alleviates medical personnel's work and also facilitates patient; Be affixed on human body and feel comfortable, non-stimulated to skin, not irritated, monitoring can be done for a long time and use; Easy to operate, without pain when pasting skin and peel off skin; Production cost is low;
(3) Biological intelligent glue of the present invention is applicable to the manufacture of emergency treatment cardiac monitoring, severe cardiac monitoring, dynamic ecg recordings examination or Treadmill Exercise Test cardiac monitoring device electrode used, has very strong practicality and promotional value.
Embodiment
Explain the present invention further below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
Embodiment 1 adopts following concrete steps to manufacture Biological intelligent glue of the present invention:
(1) following raw material is got by weight ratio: sodium alginate 12%, chitosan 10%, polyvinyl alcohol 40%, glycerine 20%, carbomer 15%, N, N-methylene-bisacrylamide 2%, azo-bis-iso-dimethyl 1%, sequentially the sodium alginate of above-mentioned taking-up, chitosan, polyvinyl alcohol, glycerine, carbomer are put into agitator, room temperature be 16 DEG C, under humidity is the environment of 25%, after stirring 8 hours with the stirrer of 600 revs/min of rotating speeds, stop stirrer, make the temperature of the liquid of acquisition be down to 16 DEG C;
(2) restart stirrer, stir 4 hours with the rotating speed of 800 revs/min, then add N,N methylene bis acrylamide 2%, continue stirring 3 hours, then add azo-bis-iso-dimethyl 1%, continue stirring and stop after 3 hours stirring;
(3) raw material be stirred that step (2) obtains is placed in room temperature is 16 DEG C, humidity is leave standstill de-bubble 8 hours under the environment of 25%;
(4) after leaving standstill end, start glue making machine, curing setting is temperature required, heat up, load onto polyethylene terephthalate (PET) glued membrane, load onto the blue film of PET, load onto arteries and veins silk, adjust all deviation-rectifying systems, it is synchronous with the radix of winder that the radix taking out glue pump is set, opens the air intake filter of machine, after infrared rays curing temperature reaches 150 DEG C, open machine exhaust system, then press the automatic button of machine, can Biological intelligent glue be produced.
Embodiment 2 adopts following concrete steps to manufacture Biological intelligent glue of the present invention:
(1) following raw material is got by weight ratio: sodium alginate 10%, chitosan 6%, polyvinyl alcohol 45%, glycerine 16%, carbomer 20%, N, N-methylene-bisacrylamide 1%, azo-bis-iso-dimethyl 2%, sequentially the sodium alginate of above-mentioned taking-up, chitosan, polyvinyl alcohol, glycerine, carbomer are put into agitator, room temperature be 14 DEG C, under humidity is the environment of 20%, after stirring 7 hours with the stirrer of 800 revs/min of rotating speeds, stop stirrer, make the temperature of the liquid of acquisition be down to 14 DEG C;
(2) restart stirrer, stir 6 hours with the rotating speed of 800 revs/min, then add N,N methylene bis acrylamide 1%, continue stirring 5 hours, then add azo-bis-iso-dimethyl 2%, continue stirring and stop after 4 hours stirring;
(3) raw material be stirred that step (2) obtains is placed in room temperature is 14 DEG C, humidity is leave standstill de-bubble 7 hours under the environment of 20%;
(4) after leaving standstill end, start glue making machine, curing setting is temperature required, heat up, load onto polyethylene terephthalate (PET) glued membrane, load onto the blue film of PET, load onto arteries and veins silk, adjust all deviation-rectifying systems, it is synchronous with the radix of winder that the radix taking out glue pump is set, opens the air intake filter of machine, after infrared rays curing temperature reaches 140 DEG C, open machine exhaust system, then press the automatic button of machine, can Biological intelligent glue be produced.
Embodiment 3 adopts following concrete steps to manufacture Biological intelligent glue of the present invention:
(1) following raw material is got by weight ratio: sodium alginate 8%, chitosan 10%, polyvinyl alcohol 38%, glycerine 25%, carbomer 15%, N, N-methylene-bisacrylamide 3%, azo-bis-iso-dimethyl 1%, sequentially the sodium alginate of above-mentioned taking-up, chitosan, polyvinyl alcohol, glycerine, carbomer are put into agitator, room temperature be 16 DEG C, under humidity is the environment of 25%, after stirring 8 hours with the stirrer of 600 revs/min of rotating speeds, stop stirrer, make the temperature of the liquid of acquisition be down to 16 DEG C;
(2) restart stirrer, stir 4 hours with the rotating speed of 800 revs/min, then add N,N methylene bis acrylamide 3%, continue stirring 3 hours, then add azo-bis-iso-dimethyl 1%, continue stirring and stop after 3 hours stirring;
(3) raw material be stirred that step (2) obtains is placed in room temperature is 16 DEG C, humidity is leave standstill de-bubble 8 hours under the environment of 25%;
(4) after leaving standstill end, start glue making machine, curing setting is temperature required, heat up, load onto polyethylene terephthalate (PET) glued membrane, load onto the blue film of PET, load onto arteries and veins silk, adjust all deviation-rectifying systems, it is synchronous with the radix of winder that the radix taking out glue pump is set, opens the air intake filter of machine, after infrared rays curing temperature reaches 150 DEG C, open machine exhaust system, then press the automatic button of machine, can Biological intelligent glue be produced.
Embodiment 4 adopts following concrete steps to manufacture Biological intelligent glue of the present invention:
(1) following raw material is got by weight ratio: sodium alginate 20%, chitosan 16%, polyvinyl alcohol 35%, glycerine 17%, carbomer 10%, N, N-methylene-bisacrylamide 1.5%, azo-bis-iso-dimethyl 0.5%, sequentially the sodium alginate of above-mentioned taking-up, chitosan, polyvinyl alcohol, glycerine, carbomer are put into agitator, room temperature be 15 DEG C, under humidity is the environment of 18%, after stirring 9 hours with the stirrer of 700 revs/min of rotating speeds, stop stirrer, make the temperature of the liquid of acquisition be down to 15 DEG C;
(2) restart stirrer, stir 4 hours with the rotating speed of 900 revs/min, then add N,N methylene bis acrylamide 1.5%, continue stirring 2 hours, then add azo-bis-iso-dimethyl 0.5%, continue stirring and stop after 5 hours stirring;
(3) raw material be stirred that step (2) obtains is placed in room temperature is 15 DEG C, humidity is leave standstill de-bubble 9 hours under the environment of 18%;
(4) after leaving standstill end, start glue making machine, curing setting is temperature required, heat up, load onto polyethylene terephthalate (PET) glued membrane, load onto the blue film of PET, load onto arteries and veins silk, adjust all deviation-rectifying systems, it is synchronous with the radix of winder that the radix taking out glue pump is set, opens the air intake filter of machine, after infrared rays curing temperature reaches 180 DEG C, open machine exhaust system, then press the automatic button of machine, can Biological intelligent glue be produced.
Claims (1)
1. a Biological intelligent glue, it is characterized in that: be made up of the raw material of following weight proportion: sodium alginate 8-20%, chitosan 6-16%, polyvinyl alcohol 35-45%, glycerine 16-25%, carbomer 10-20%, N, N-methylene-bisacrylamide 1-3%, azo-bis-iso-dimethyl 0.5-2%, its preparation method is following concrete steps:
(1) following raw material is got by weight ratio: sodium alginate 8-20%, chitosan 6-16%, polyvinyl alcohol 35-45%, glycerine 16-25%, carbomer 10-20%, N, N-methylene-bisacrylamide 1-3%, azo-bis-iso-dimethyl 0.5-2%, sequentially the sodium alginate of above-mentioned taking-up, chitosan, polyvinyl alcohol, glycerine, carbomer are put into agitator, room temperature be 14-16 DEG C, under humidity is the environment of 18-25%, after stirring 7-9 hour with the stirrer of 600-800 rev/min of rotating speed, stop stirrer, make the temperature of the liquid of acquisition be down to 14-16 DEG C;
(2) restart stirrer, stir 4-6 hour with the rotating speed of 800-900 rev/min, then add N, N-methylene-bisacrylamide 1-3%, continue to stir 2-5 hour, then add azo-bis-iso-dimethyl 0.5-2%, continue to stir stopping after 3-5 hour and stir;
(3) raw material be stirred that step (2) obtains is placed in room temperature is 14-16 DEG C, humidity is leave standstill de-bubble 7-9 hour under the environment of 18-25%;
(4) after leaving standstill end, start glue making machine, curing setting is temperature required, heat up, load onto polyethylene terephthalate (PET) glued membrane, load onto the blue film of PET, load onto arteries and veins silk, adjust all deviation-rectifying systems, it is synchronous with the radix of winder that the radix taking out glue pump is set, opens the air intake filter of machine, after infrared rays curing temperature reaches 140-180 DEG C, open machine exhaust system, then press the automatic button of machine, can Biological intelligent glue be produced.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310174037.1A CN103242779B (en) | 2013-05-13 | 2013-05-13 | Biological intelligent glue |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310174037.1A CN103242779B (en) | 2013-05-13 | 2013-05-13 | Biological intelligent glue |
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| CN103242779A CN103242779A (en) | 2013-08-14 |
| CN103242779B true CN103242779B (en) | 2015-05-06 |
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| CN201310174037.1A Expired - Fee Related CN103242779B (en) | 2013-05-13 | 2013-05-13 | Biological intelligent glue |
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| US20140261075A1 (en) | 2013-03-12 | 2014-09-18 | University Of Louisiana At Lafayette | System and methods for treatment of biomass products or residues and resulting composition |
| CN111904409A (en) * | 2020-06-11 | 2020-11-10 | 西安交通大学医学院第一附属医院 | Flexible sensor for electrocardio monitoring and hydrogel flexible electrocardio monitor |
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| CN100588437C (en) * | 2008-05-14 | 2010-02-10 | 天津大学 | Therapy electrode tablet clamping self-pasting medicament film and preparation method thereof |
| US9574109B2 (en) * | 2010-02-18 | 2017-02-21 | Dow Corning Corporation | Surface-modified hydrogels and hydrogel microparticles |
| CN103083713B (en) * | 2012-12-10 | 2015-12-23 | 江苏华亿细胞组织工程有限公司 | A kind of aseptic polymerization wound-surface cover dressing |
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