CN103203127A - Lipidosome extruding and filtering device - Google Patents
Lipidosome extruding and filtering device Download PDFInfo
- Publication number
- CN103203127A CN103203127A CN2013101133985A CN201310113398A CN103203127A CN 103203127 A CN103203127 A CN 103203127A CN 2013101133985 A CN2013101133985 A CN 2013101133985A CN 201310113398 A CN201310113398 A CN 201310113398A CN 103203127 A CN103203127 A CN 103203127A
- Authority
- CN
- China
- Prior art keywords
- external seal
- extruding
- valve body
- filter
- groove
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Medicinal Preparation (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention provides a lipidosome extruding and filtering device which comprises a material discharge pipe, an upper cover, an extruding outer seal gasket, a support plate, a filtering plate, a filtering membrane, an extruding inner seal gasket, a connector, a hoop and a hoop locking bolt; the center of the connector is provided with a material charge through hole; the center of the upper cover is provided a material discharge through hole of which the opening at the upper end is connected with the material discharge pipe; the bottom surface of the upper cover is provided with an annular seal groove and an internally sinking cylindrical groove; the support plate, the filtering plate, the filtering membrane and the extruding inner seal gasket are sequentially arranged in the cylindrical groove from inward to outward; the extruding outer seal gasket is arranged in the annular seal groove; the upper cover and the connector are fixed together through the hoop and the hoop locking bolt. According to the invention, nanocrystallized equipment and homogenized equipment are designed integrally; material particle size can be controlled accurately through replacing different filtering membranes; cross contamination is prevented; and the lipidosome extruding and filtering device is convenient to use, and can be widely applied to the nano medicament field.
Description
Technical field
The present invention relates to a kind of high pressure filtering device, particularly, relate to a kind of liposome and extrude filter.
Background technology
When amphiphatic molecule such as phosphatide and sphingolipid were scattered in water, the hydrophobic tail of molecule was tended to flock together, and avoids water, and hydrophilic head is exposed to water, formation have the bilayer structure vesicle, be called liposome, diameter 25～1000nm does not wait.Liposome is a kind of targeted drug carrier, belongs to a kind of novel form of targeting drug delivery system.It can be embedded in diameter with drug powder or solution is in the nano level particulate, this particulate has the class eucaryotic cell structure, enter the autoimmune function that is mainly activated body in the human body by reticuloendothelial system phagocytic, and the interior distribution of the body that changes encapsulated medicine, drug main will be put aside in histoorgans such as liver, spleen, lung and marrow, thereby improve the therapeutic index of medicine, reduce the toxicity of therapeutic dose and the reduction medicine of medicine.
Liposome is the core material of Nano medication now, and the medicament of pharmaceutical industry is to the strict demand that has of liposome particle diameter, and particle diameter must satisfy in certain unit, and the distribution homogeneous.So the core of preparation liposome is the nanometer of liposome and the accurate control of liposome particle diameter, this uses high pressure homogenizer with regard to needs and extrudes filter and carry out nanometer processing and homogenization processing respectively.
The existing product high pressure homogenizer with extrude filter and separate, can cause cross pollution, and use troublesome poeration and safeguard inconvenience.
Therefore, be necessary to develop a kind of novel preparation nanometer, the device of uniform particle diameter liposome.
Summary of the invention
The objective of the invention is to overcome the defective that above-mentioned prior art exists and provide a kind of liposome to extrude filter, liposome provided by the invention is extruded filter and is realized filtering out the liposome of different-grain diameter by changing different filter membranes, effectively get rid of the liposome greater than the demand particle diameter, realized the accurate control of particle diameter, and avoided cross pollution, operation and maintenance is also convenient, can be widely used in the Nano medication field.
Purpose of the present invention is achieved through the following technical solutions, a kind of liposome is extruded filter, comprise: discharge nozzle, loam cake, extrude external seal pad, gripper shoe, filter plate, filter membrane, extrude interior sealing gasket, joint, valve body external seal pad, clip, locked clip device bolt and valve body external seal groove, described valve body external seal groove is arranged on the lower end outer rim of described joint, described valve body external seal pad is arranged on the inside of described valve body external seal groove, and the center of described joint is provided with a charging through hole; The center of described loam cake is provided with one and goes out material through hole, the described upper end open that goes out material through hole is connected with described discharge nozzle, the bottom surface of described loam cake arranges a cylinder shape groove that caves in and an annular seal groove, described annular seal groove is positioned at the outside of described cylinder shape groove, sealing gasket is successively set in the described cylinder shape groove from inside to outside in described gripper shoe, described filter plate, described filter membrane, described the extruding, and the described external seal pad of extruding is arranged in the described annular seal groove; Described loam cake and described joint are in the same place by described clip and described locked clip device bolting.
Preferably, described filter membrane is polycarbonate leaching film.
Preferably, describedly extrude interior sealing gasket, describedly extrude the external seal pad and described valve body external seal pad all adopts fluorine glue and polyurethane material to make.
Compared with prior art, the present invention has following beneficial effect: the present invention will be by combining high pressure homogenizer and high-pressure filteration module, realize the integrated design of nanometer equipment and homogenization equipment, high pressure homogenizer can be realized the nanometer of liposome, then liposome extrude filter by power source mass transport in its working chamber, directly realize the accurate control of particle diameter by the high-pressure filteration module, and realize filtering out the liposome of different-grain diameter by changing different filter membranes, effectively get rid of the liposome greater than the demand particle diameter, realized the accurate control of particle diameter, and avoided cross pollution, operation and maintenance is also convenient.
Description of drawings
By reading the detailed description of non-limiting example being done with reference to the following drawings, it is more obvious that other features, objects and advantages of the present invention will become:
Fig. 1 is the three-dimensional structure diagram that liposome provided by the invention is extruded filter.
Fig. 2 be among Fig. 1 along A to side view.
Fig. 3 be among Fig. 1 along B to side view.
Fig. 4 be liposome shown in Figure 1 extrude filter vertical view.
Fig. 5 is the exploded view that liposome shown in Figure 1 is extruded filter.
Fig. 6 is that liposome provided by the invention is extruded filter and the matching used complete layout of homogenizer.
Among the figure: 1 for filter membrane, 7 for extrude interior sealing gasket, 8 for joint, 9 for valve body external seal pad, 10 for clip, 11 for locked clip device bolt, 12 for valve body external seal groove, 13 is of the present invention liposome extrude filter, 14 be homogenizer for filter plate, 6 for extruding external seal pad, 4 for gripper shoe, 5 for loam cake, 3 for discharge nozzle, 2.
The specific embodiment
The present invention is described in detail below in conjunction with specific embodiment.Following examples will help those skilled in the art further to understand the present invention, but not limit the present invention in any form.Should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, can also make some distortion and improvement.These all belong to protection scope of the present invention.
Embodiment 1, liposome extrudes filter
Extrude filter 13 as Fig. 1 to a kind of liposome shown in Figure 5, comprise: discharge nozzle 1, loam cake 2, extrude external seal pad 3, gripper shoe 4, filter plate 5, filter membrane 6, extrude in sealing gasket 7, joint 8, valve body external seal pad 9, clip 10, locked clip device bolt 11 and valve body external seal groove 12, described valve body external seal groove 12 is arranged on the lower end outer rim of described joint 8, described valve body external seal pad 9 is arranged on the inside of described valve body external seal groove 12, and the center of described joint 8 is provided with a charging through hole; The center of described loam cake 2 is provided with one and goes out material through hole, the described upper end open that goes out material through hole is connected with described discharge nozzle 1, the bottom surface of described loam cake 2 arranges a cylinder shape groove that caves in and an annular seal groove, described annular seal groove is positioned at the outside of described cylinder shape groove, sealing gasket 7 is successively set in the described cylinder shape groove from inside to outside in described gripper shoe 4, described filter plate 5, described filter membrane 6, described the extruding, and the described external seal pad 3 of extruding is arranged in the described annular seal groove; Described loam cake 2 is fixed together by described clip 10 and described locked clip device bolt 11 with described joint 8; Sealing gasket 7 in described the extruding, describedly extrude external seal pad 3 and described valve body external seal pad 9 all adopts the fluorine glue material to make, described filter membrane 6 is polycarbonate leaching film.Liposome is extruded filter 13 and homogenizer 14 supporting uses (as shown in Figure 6), and reaches homogeneous and extrude synchronously and carry out.
Embodiment 2, liposome extrudes filter
Extrude filter 13 as Fig. 1 to a kind of liposome shown in Figure 5, comprise: discharge nozzle 1, loam cake 2, extrude external seal pad 3, gripper shoe 4, filter plate 5, polycarbonate leaching film 6, extrude in sealing gasket 7, joint 8, valve body external seal pad 9, clip 10, locked clip device bolt 11 and valve body external seal groove 12, described valve body external seal groove 12 is arranged on the lower end outer rim of described joint 8, described valve body external seal pad 9 is arranged on the inside of described valve body external seal groove 12, and the center of described joint 8 is provided with a charging through hole; The center of described loam cake 2 is provided with one and goes out material through hole, the described upper end open that goes out material through hole is connected with described discharge nozzle 1, the bottom surface of described loam cake 2 arranges a cylinder shape groove that caves in and an annular seal groove, described annular seal groove is positioned at the outside of described cylinder shape groove, sealing gasket 7 is successively set in the described cylinder shape groove from inside to outside in described gripper shoe 4, described filter plate 5, described filter membrane 6, described the extruding, and the described external seal pad 3 of extruding is arranged in the described annular seal groove; Described loam cake 2 is fixed together by described clip 10 and described locked clip device bolt 11 with described joint 8, sealing gasket 7 in described the extruding, describedly extrude external seal pad 3 and described valve body external seal pad 9 all adopts polyurethane material to make, described filter membrane 6 is polycarbonate leaching film.Liposome is extruded filter 13 and homogenizer 14 supporting uses (as shown in Figure 6), and reaches homogeneous and extrude synchronously and carry out.
More than specific embodiments of the invention are described.It will be appreciated that the present invention is not limited to above-mentioned specific implementations, those skilled in the art can make various distortion or modification within the scope of the claims, and this does not influence flesh and blood of the present invention.
Claims (3)
1. a liposome is extruded filter, it is characterized in that, comprise discharge nozzle (1), loam cake (2), extrude external seal pad (3), gripper shoe (4), filter plate (5), filter membrane (6), extrude interior sealing gasket (7), joint (8), valve body external seal pad (9), clip (10), locked clip device bolt (11) and valve body external seal groove (12), described valve body external seal groove (12) is arranged on the lower end outer rim of described joint (8), described valve body external seal pad (9) is arranged on the inside of described valve body external seal groove (12), and the center of described joint (8) is provided with a charging through hole; The center of described loam cake (2) is provided with one and goes out material through hole, the described upper end open that goes out material through hole is connected with described discharge nozzle (1), the bottom surface of described loam cake (2) arranges a cylinder shape groove that caves in and an annular seal groove, described annular seal groove is positioned at the outside of described cylinder shape groove, described gripper shoe (4), described filter plate (5), described filter membrane (6), the described interior sealing gasket (7) of extruding are successively set in the described cylinder shape groove from inside to outside, and the described external seal pad (3) of extruding is arranged in the described annular seal groove; Described loam cake (2) is fixed together by described clip (10) and described locked clip device bolt (11) with described joint (8).
2. liposome according to claim 1 is extruded filter, it is characterized in that, described filter membrane (6) is polycarbonate leaching film.
3. liposome according to claim 1 and 2 is extruded filter, it is characterized in that, describedly extrudes interior sealing gasket (7), describedly extrudes external seal pad (3) and described valve body external seal pad (9) all adopts fluorine glue or polyurethane material to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310113398.5A CN103203127B (en) | 2013-04-02 | 2013-04-02 | Liposome extrudes filter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310113398.5A CN103203127B (en) | 2013-04-02 | 2013-04-02 | Liposome extrudes filter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103203127A true CN103203127A (en) | 2013-07-17 |
| CN103203127B CN103203127B (en) | 2015-09-02 |
Family
ID=48750660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310113398.5A Active CN103203127B (en) | 2013-04-02 | 2013-04-02 | Liposome extrudes filter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103203127B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877766A (en) * | 2014-03-27 | 2014-06-25 | 东莞市新懿电子材料技术有限公司 | Filter for filtering liquid |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06501646A (en) * | 1990-10-05 | 1994-02-24 | ザ リポソーム カンパニー，インコーポレイテッド | Liposome extrusion method |
| EP1632279A1 (en) * | 2004-09-02 | 2006-03-08 | Millipore Corporation | Port adapter for a tangetial flow filtration casette |
| CN101898056A (en) * | 2009-12-28 | 2010-12-01 | 嘉兴市蝶柔化妆品有限公司 | Feeding and filtering device for homogenizer |
| CN202237452U (en) * | 2011-09-15 | 2012-05-30 | 上海安谱科学仪器有限公司 | Structure of pinhead type filter |
| CN202822916U (en) * | 2012-09-29 | 2013-03-27 | 吉林大学 | Extrusion device of tangential flow liposome |
| CN203154907U (en) * | 2013-04-02 | 2013-08-28 | 上海正乾生物技术有限公司 | Liposome extruding and filtering device |
-
2013
- 2013-04-02 CN CN201310113398.5A patent/CN103203127B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06501646A (en) * | 1990-10-05 | 1994-02-24 | ザ リポソーム カンパニー，インコーポレイテッド | Liposome extrusion method |
| EP1632279A1 (en) * | 2004-09-02 | 2006-03-08 | Millipore Corporation | Port adapter for a tangetial flow filtration casette |
| CN101898056A (en) * | 2009-12-28 | 2010-12-01 | 嘉兴市蝶柔化妆品有限公司 | Feeding and filtering device for homogenizer |
| CN202237452U (en) * | 2011-09-15 | 2012-05-30 | 上海安谱科学仪器有限公司 | Structure of pinhead type filter |
| CN202822916U (en) * | 2012-09-29 | 2013-03-27 | 吉林大学 | Extrusion device of tangential flow liposome |
| CN203154907U (en) * | 2013-04-02 | 2013-08-28 | 上海正乾生物技术有限公司 | Liposome extruding and filtering device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877766A (en) * | 2014-03-27 | 2014-06-25 | 东莞市新懿电子材料技术有限公司 | Filter for filtering liquid |
| CN103877766B (en) * | 2014-03-27 | 2015-07-08 | 东莞市新懿电子材料技术有限公司 | Filter for filtering liquid |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103203127B (en) | 2015-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104244905B (en) | Pressure equaliser and reservoir | |
| CN106170316A (en) | Transdermal drug delivery equipment and method | |
| CN105456228B (en) | One kind contains aprepitant nanocrystal lipid microcapsule and preparation method thereof | |
| CN102349998A (en) | Hydrophobic anticancer medicinal preparation on basis of exosome | |
| CN203154907U (en) | Liposome extruding and filtering device | |
| CN103203127A (en) | Lipidosome extruding and filtering device | |
| CN103192516B (en) | High-pressure extruding and filtering system for preparing liposome | |
| CN202822916U (en) | Extrusion device of tangential flow liposome | |
| CN104888670A (en) | Method for preparing natural polymer double-layer microcapsule through adoption of gas-liquid micro-channel | |
| CN203171996U (en) | High-pressure extruding and filtering system for preparing lipidosome | |
| CN202568887U (en) | Structural improved capsule | |
| US20140039237A1 (en) | Medication dispensing device | |
| CN103709420A (en) | Micro-reaction device for quickly preparing composite polymer nanoparticles | |
| CN204016993U (en) | Polyolefin precision infusion set | |
| CN207672051U (en) | A kind of histocyte separation instrument | |
| CN203436562U (en) | Filtering type transfusion bag | |
| CN103393542B (en) | A kind of filtering type transfusion bag | |
| CN207981215U (en) | A kind of liposome extruder | |
| CN106727393A (en) | A kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof | |
| CN208876500U (en) | Dehydration device and patient monitor | |
| CN1767865A (en) | A filter for a cartridge, a cartridge, use of a filter in a cartridge and a system for preparing a liquid solution for a medical procedure | |
| CN103239399B (en) | A kind of sirolimus nano suspension and preparation method thereof | |
| CN207793282U (en) | Culture bottle for the automatic amplification cultivation of cell | |
| CN205108565U (en) | Non - direct -connected venous transfusion ware | |
| CN201643231U (en) | Novel injector push rod |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20151221 Address after: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215000 BioBAY No. 218 building 106 unit A4 Patentee after: Advanced nano technology (Suzhou) Co., Ltd. Address before: 201111, room 208, building B, 2118 Guanghua Road, Shanghai, Minhang District, China, room -E Patentee before: Shanghai Zhengqian Biological Technology Co., Ltd. |