CN103203011A - Chewing gum for preventing and treating oral ulcer after chemotherapy - Google Patents
Chewing gum for preventing and treating oral ulcer after chemotherapy Download PDFInfo
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- CN103203011A CN103203011A CN 201310004799 CN201310004799A CN103203011A CN 103203011 A CN103203011 A CN 103203011A CN 201310004799 CN201310004799 CN 201310004799 CN 201310004799 A CN201310004799 A CN 201310004799A CN 103203011 A CN103203011 A CN 103203011A
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Abstract
The invention relates to a chewing gum for preventing and treating oral ulcer after chemotherapy. The chewing gum is composed of chewing gum ingredients and drugs used for preventing and treating oral ulcer. Each 100 g of the chewing gum for preventing and treating oral ulcer after chemotherapy comprises the following drugs used for preventing and treating oral ulcer: 5 to 10 mg of a recombinant human granulocyte colony stimulating factor, 5 to 10 mg of folic acid, 5 to 10 mg of metronidazole, 20 to 50 mg of lidocaine, 5 to 20 mg of cimetidine and 2.5 to 10 mg of vitamin B2, with the balance being the chewing gum ingredients. The chewing gum ingredients comprise, by weight, 25 to 30% of an edible gum base, 20 to 25% of maltose syrup, 35 to 45% of xylitol and 10 to 20% of sorbitol. The chewing gum provided by the invention can effectively prevent and treat oral ulcer resulting from different causes after chemotherapy, mitigate stimulation of the drugs on gastrointestinal tracts, reduce occurrence of adverse reactions and improve safety, has good taste and is convenient to take.
Description
Technical field
The present invention relates to a kind of chewing gum, be specifically related to a kind of chewing gum of preventing and treating oral ulcer after the chemotherapy.
Background technology
Chewing gum is as a kind of celebrated, and snacks between all-ages meal can not only fresh breath, promotes the production of body fluid that it is fragrant to coagulate, happy tasty and refreshing larynx, but also have relieving stress, hypermnesis prevents effects such as decayed tooth.Domesticly discover the clean the teeth generation of oral ulcer after the chemotherapy of chewing gum, reduced the infection complication, the patient can normally take food and sleep, thereby is conducive to carrying out smoothly of chemotherapy.Chewing gum is delicious and cheap, and the patient chews simple and easy to do, and is acceptant, has no adverse reaction.
Along with the continuous research and development of new chemotherapeutics, treatment with chemotherapy Drug therapy malignant tumor has become the tumor conventional treatments.But because the chemotherapeutics toxic action, tumor patient mucositis incidence rate in accepting the process of chemotherapy is 75%, and concurrent oral ulcer, infection rate are up to 66%, and the nutrition that has had a strong impact on patient is taken in.Because oral ulcer causes oral bacterial infections easily, thereby increases the weight of ulcer, form vicious cycle.Ulcer not only directly influences patient's life quality, also can cause chemotherapy to be interrupted and even failure because of serious mucosa reaction.In recent years the research of oral cavity ulcer treatment and nursing is paid attention to by people day by day.
Defectives such as the pharmaceutical dosage form for the treatment of oral ulcer is mainly external pulvis, spray, ointment or drop pill at present, and the medicine of these dosage forms is all having mouthfeel poor in varying degrees, uses inconvenience, and duration of efficacy is short.For example CN 1814098 A disclose a kind of Chinese powder medicine for the treatment of oral ulcer, and to light-duty oral ulcer, and the mycotic oral cavity infection that the chemotherapy broad ectrum antibiotic causes is effective equally.CN 1857323 A disclose a kind of preparation and application of propolis dripping pill, oral cavity ulcer behind this propolis dripping pill treatment tumor chemoradiotherapy.
Occurred in recent years medicine is introduced the health-care chewing gum that traditional chewing gum is used for anti-treating dental ulcer, had easy to carryly, mouthfeel is pleasant, effective ingredient slowly discharges, and acts on the oral cavity, namely reaches cleaning oral cavity, the dual purpose that anti-treating dental ulcer is arranged is the health food that suits the taste of both old and young.CN 101675748A discloses a kind of novel tooth-protecting chewing gum, and zinc gluconate and bi-quaternary ammonium salt are introduced chewing gum, reaches the effect of repairing oral ulcer.CN 101731417A discloses a kind of chitosan chewing gum, and the chitosan that will have the bactericidal antiphlogistic effect is introduced chewing gum, prevents oral ulcer, bactericidal antiphlogistic.CN 1634023A discloses the chewing gum of a kind of anti-treating dental ulcer and toothache, and department of stomatology medicines such as Borax, nitrofural, dexamethasone acetate and iodine are added chewing gum, plays anti-treating dental ulcer.CN101019592A discloses bamboo salt chewing gum and bubble gum, and the adding of bamboo salt composition can be accelerated the recovery of oral ulcer.CN 1076338A discloses a kind of production method of health-care chewing gum, Chinese medicine such as Radix Zanthoxyli, Herba Pileae Scriptae, Radix Notoginseng etc. will be added in the chewing gum, and Western medicine such as metronidazole, vitamin E, vitamin B2 and vitamin C, this chewing gum has remarkable prevention effect to oral ulcer.CN 101036679A discloses Gynura procumbens chewing gums and preparation method thereof, it contains 1-20% Gynura procumbens (Lour.) Merr. extract, the edible gum base of 10-21%, 50-70% sweeting agent, 1-4% flavorant, also can add the peppermint candy of 0.1-0.4%, the Mentholum of 0.1-0.8%, this chewing gum has antibiotic, antiinflammatory preferably, pain relieving and anastalsis.Above-mentioned oral cavity health chewing gum, the ingredient of introducing is all inequality, and certain oral ulcer prevention effect is all arranged, but its oral ulcer that chemotherapy is caused is difficult to obtain satisfied prevention effect.
Therefore people are still seeking at the better chewing gum formulations of oral ulcer curative effect, to produce better chewing gum.
Summary of the invention
At the relatively poor problem of curative effect of preventing and treating the health-care chewing gum of oral ulcer after the chemotherapy at present, the invention provides a kind of chewing gum of preventing and treating oral ulcer after the chemotherapy, can prevent and treat the oral ulcer that the different causes of disease cause after the chemotherapy effectively; Can also reduce medicine stimulates gastrointestinal, reduces the generation of untoward reaction, increases safety; Mouthfeel is good, taking convenience.
The present invention also provides the above-mentioned its preparation method of preventing and treating the chewing gum of oral ulcer after the chemotherapy.
Purpose of the present invention realizes by the following technical solutions:
A kind of chewing gum of preventing and treating oral ulcer after the chemotherapy is made up of chewing gum batching and control stomatocace medicine, it is characterized in that: per 100 grams are prevented and treated to contain in the chewing gum of oral ulcer after the chemotherapy and are prevented and treated stomatocace medicine and be respectively:
Described chewing gum batching is edible gum base and sweeting agent; Described sweeting agent is maltose syrup, xylitol and Sorbitol;
The percentage by weight of each component is respectively in the described chewing gum batching:
Edible gum base 25～30%,
Maltose syrup 20～25%,
Xylitol 35～45%,
Sorbitol 10～20%.
Since chemotherapeutics such as methotrexate (MTX) and folic acid competition, thus cellular metabolism influenced, causing serious oral ulcer, the purpose of Supplement of folic acid is in order to keep Normocellular activity, anti-treating dental ulcer.Chemotherapy is bigger to the toxic and side effects of body, and folic acid can be alleviated the vomiting that chemotherapy causes effectively, appetite these malaise symptoms that descend.
Adding recombinant human granulocyte colony stimulating factor is in order to accelerate the ulcer surface healing.
Metronidazole tool wide spectrum anaerobe resistant and protozoacidal effect are widely used in preventing and treating oral cavity anaerobium and infect and peptic ulcer.
Pain is one of common clinical manifestation of oral ulcer.Lignocaine is to imitate local anesthetic in the amide-type, is mainly used in topical anesthesia, because its anaphylaxis incidence rate is lower, need not make skin test, and the pain of therefore using low concentration lignocaine treatment oral disease is safe and effective.
Cimetidine can be regulated immunologic function, and pain relieving is arranged and promote the regeneration of chronic ulcer tissue, the effect of reparation.
Vitamin B2 is the constituent of the important prothetic group of many enzyme systems in the body, participates in material and energy metabolism.The B2 that is deficient in vitamin can cause stomatitis, cheilitis, angular cheilitis, glossitis, causes oral ulcer.Therefore vitimin supplement B2 can prevent and treat the oral ulcer that the B2 that is deficient in vitamin brings out.
Described preparation method of preventing and treating the chewing gum of oral ulcer after the chemotherapy comprises following concrete steps:
The first step takes by weighing the chewing gum furnish component in proportion; By edible gum base 25～30%, maltose syrup 20～25%, xylitol 35～45%, the percentage by weight of Sorbitol 10～20% is weighed and is got the raw materials ready;
In second step, mix xylitol and Sorbitol; With xylitol, the Sorbitol mix homogeneously that takes by weighing, put into the sterilization of 80 ℃ of baking ovens after, obtain the mixture of xylitol and Sorbitol;
The 3rd step, softening edible gum base; The edible gum base heating (edible gum base is heated to 80-120 ℃ and fully stirs, and after 5-10 minute, stops heating) that takes by weighing is softening; Simultaneously the maltose syrup that takes by weighing is heated to 100 ℃;
The 4th step, preparation chewing gum batching; With mixture, the 3rd step of second xylitol that obtain of step and Sorbitol obtain softening after edible gum base and be heated to 100 ℃ maltose syrup and evenly mix and obtain the chewing gum batching, cool to room temperature is standby then;
In the 5th step, take by weighing control stomatocace medicine component in proportion; Prevent and treat the recombinant human granulocyte colony stimulating factor that the chewing gum of oral ulcer after the chemotherapy takes by weighing 5～10 milligrams by per 100 grams, 5～10 milligrams folic acid, 5～10 milligrams metronidazole, 20～50 milligrams lignocaine, 5～20 milligrams cimetidine, 2.5～10 milligrams vitamin B2, surplus are the chewing gum batching that made in the 4th step;
In the 6th step, mix control stomatocace medicine and chewing gum batching;
Add folic acid, recombinant human granulocyte colony stimulating factor, metronidazole, lignocaine, cimetidine and the vitamin B2 that takes by weighing in the chewing gum batching that makes in the 4th step, stir evenly and evenly extrude and roll flakiness;
In the 7th step, the thin slice reprocessing molding that the 6th step was obtained obtains the described chewing gum of preventing and treating oral ulcer after the chemotherapy, and 50 grams/grain are finally by check, be packaged as finished product.
Beneficial effect of the present invention is: with chewing gum with folic acid, recombinant human granulocyte colony stimulating factor, metronidazole, lignocaine, cimetidine, several control stomatocace medicine set of vitamin B2, can promote the synergism of each effective ingredient, prevent and treat the oral ulcer that the different causes of disease cause after the chemotherapy effectively, strengthen the ability of oral cavity bacterial-infection resisting, thereby improve the effect of anti-treating dental ulcer; Medicine can directly absorb by sublingual vein when chewing gum of the present invention was chewed by the oral cavity, reduce owing to the destruction of gastrointestinal enzyme regulating liver-QI enzyme (first pass effect) to medicine, improved bioavailability, reduce the dose of medicine, can also reduce medicine stimulates gastrointestinal, reduce the generation of untoward reaction, increased safety; Mouthfeel is good, taking convenience.
The specific embodiment
A kind of chewing gum of preventing and treating oral ulcer after the chemotherapy of the present invention is made up of chewing gum batching and control stomatocace medicine, it is characterized in that: per 100 grams are prevented and treated to contain in the chewing gum of oral ulcer after the chemotherapy and are prevented and treated stomatocace medicine and be respectively:
Described chewing gum batching is edible gum base and sweeting agent; Described sweeting agent is maltose syrup, xylitol and Sorbitol;
The percentage by weight of each component is respectively in the described chewing gum batching:
Edible gum base 25～30%,
Maltose syrup 20～25%,
Xylitol 35～45%,
Sorbitol 10～20%.
Embodiment one: described preparation method of preventing and treating the chewing gum of oral ulcer after the chemotherapy comprises following concrete steps:
The first step takes by weighing the chewing gum furnish component in proportion; Take by weighing edible gum base 25 grams, maltose syrup 20 grams, xylitol 35 grams, Sorbitol 20 grams;
In second step, mix xylitol and Sorbitol; With xylitol, the Sorbitol mix homogeneously that takes by weighing, put into the sterilization of 80 ℃ of baking ovens after, obtain the mixture of xylitol and Sorbitol;
The 3rd step, softening edible gum base; The edible gum base heating (edible gum base is heated to 80-120 ℃ and fully stirs, and after 5-10 minute, stops heating) that takes by weighing is softening; Simultaneously the maltose syrup that takes by weighing is heated to 100 ℃;
The 4th step, preparation chewing gum batching; With mixture, the 3rd step of second xylitol that obtain of step and Sorbitol obtain softening after edible gum base and be heated to 100 ℃ maltose syrup and evenly mix and obtain the chewing gum batching, cool to room temperature is standby then;
In the 5th step, take by weighing control stomatocace medicine component in proportion; Prevent and treat the recombinant human granulocyte colony stimulating factor that the chewing gum of oral ulcer after the chemotherapy takes by weighing 5 milligrams by per 100 grams, 5 milligrams folic acid, 5 milligrams metronidazole, 20 milligrams lignocaine, 5 milligrams cimetidine, 2.5 the vitamin B2 of milligram takes by weighing 99962.5 milligrams of the chewing gum batchings that the 4th step made;
In the 6th step, mix control stomatocace medicine and chewing gum batching;
Add folic acid, recombinant human granulocyte colony stimulating factor, metronidazole, lignocaine, cimetidine and the vitamin B2 that takes by weighing in the chewing gum batching that makes in the 4th step, stir evenly and evenly extrude and roll flakiness;
In the 7th step, the thin slice reprocessing molding that the 6th step was obtained obtains the described chewing gum of preventing and treating oral ulcer after the chemotherapy, and 50 grams/grain are finally by check, be packaged as finished product.
Embodiment two: described preparation method of preventing and treating the chewing gum of oral ulcer after the chemotherapy comprises following concrete steps:
The first step takes by weighing the chewing gum furnish component in proportion; Take by weighing edible gum base 30 grams, maltose syrup 25 grams, xylitol 35 grams, Sorbitol 10 grams;
In second step, mix xylitol and Sorbitol; With xylitol, the Sorbitol mix homogeneously that takes by weighing, put into the sterilization of 80 ℃ of baking ovens after, obtain the mixture of xylitol and Sorbitol;
The 3rd step, softening edible gum base; The edible gum base heating (edible gum base is heated to 80-120 ℃ and fully stirs, and after 5-10 minute, stops heating) that takes by weighing is softening; Simultaneously the maltose syrup that takes by weighing is heated to 100 ℃;
The 4th step, preparation chewing gum batching; With mixture, the 3rd step of second xylitol that obtain of step and Sorbitol obtain softening after edible gum base and be heated to 100 ℃ maltose syrup and evenly mix and obtain the chewing gum batching, cool to room temperature is standby then;
In the 5th step, take by weighing control stomatocace medicine component in proportion; Prevent and treat the recombinant human granulocyte colony stimulating factor that the chewing gum of oral ulcer after the chemotherapy takes by weighing 10 milligrams by per 100 grams, 10 milligrams folic acid, 10 milligrams metronidazole, 50 milligrams lignocaine, 20 milligrams cimetidine, 10 milligrams vitamin B2 takes by weighing 99900 milligrams of the chewing gum batchings that the 4th step made;
In the 6th step, mix control stomatocace medicine and chewing gum batching;
Add folic acid, recombinant human granulocyte colony stimulating factor, metronidazole, lignocaine, cimetidine and the vitamin B2 that takes by weighing in the chewing gum batching that makes in the 4th step, stir evenly and evenly extrude and roll flakiness;
In the 7th step, the thin slice reprocessing molding that the 6th step was obtained obtains the described chewing gum of preventing and treating oral ulcer after the chemotherapy, and 50 grams/grain are finally by check, be packaged as finished product.
Embodiment three: described preparation method of preventing and treating the chewing gum of oral ulcer after the chemotherapy comprises following concrete steps:
The first step takes by weighing the chewing gum furnish component in proportion; Take by weighing edible gum base 26 grams, maltose syrup 21 grams, xylitol 40 grams, Sorbitol 13 grams;
In second step, mix xylitol and Sorbitol; With xylitol, the Sorbitol mix homogeneously that takes by weighing, put into the sterilization of 80 ℃ of baking ovens after, obtain the mixture of xylitol and Sorbitol;
The 3rd step, softening edible gum base; The edible gum base heating (edible gum base is heated to 80-120 ℃ and fully stirs, and after 5-10 minute, stops heating) that takes by weighing is softening; Simultaneously the maltose syrup that takes by weighing is heated to 100 ℃;
The 4th step, preparation chewing gum batching; With mixture, the 3rd step of second xylitol that obtain of step and Sorbitol obtain softening after edible gum base and be heated to 100 ℃ maltose syrup and evenly mix and obtain the chewing gum batching, cool to room temperature is standby then;
In the 5th step, take by weighing control stomatocace medicine component in proportion; Prevent and treat the recombinant human granulocyte colony stimulating factor that the chewing gum of oral ulcer after the chemotherapy takes by weighing 8 milligrams by per 100 grams, 8 milligrams folic acid, 8 milligrams metronidazole, 36 milligrams lignocaine, 15 milligrams cimetidine, 5 milligrams vitamin B2 takes by weighing 99920 milligrams of the chewing gum batchings that the 4th step made;
In the 6th step, mix control stomatocace medicine and chewing gum batching;
Add folic acid, recombinant human granulocyte colony stimulating factor, metronidazole, lignocaine, cimetidine and the vitamin B2 that takes by weighing in the chewing gum batching that makes in the 4th step, stir evenly and evenly extrude and roll flakiness;
In the 7th step, the thin slice reprocessing molding that the 6th step was obtained obtains the described chewing gum of preventing and treating oral ulcer after the chemotherapy, and 50 grams/grain are finally by check, be packaged as finished product.
Effect assessment:
(1) do not produce oral ulcer.(2) in producing the oral ulcer patient, compare with oral ulcer conventional treatment after the chemotherapy, the ulcer area diminishes, decreased number, and pain relief, healing time obviously shortens, leaving no scar after healing.In the clinical application 35 routine patients undergoing chemotherapies, 10 examples do not produce oral ulcer; Produce effective 21 examples of ulcer 25 routine patients, total effective rate 89%, point out chewing gum of the present invention to chemotherapy after oral ulcer better preventive and therapeutic effect is arranged.
Claims (3)
1. a chewing gum of preventing and treating oral ulcer after the chemotherapy is made up of chewing gum batching and control stomatocace medicine, it is characterized in that: per 100 grams are prevented and treated to contain in the chewing gum of oral ulcer after the chemotherapy and are prevented and treated stomatocace medicine and be respectively:
Described chewing gum batching is edible gum base and sweeting agent; Described sweeting agent is maltose syrup, xylitol and Sorbitol;
The percentage by weight of each component is respectively in the described chewing gum batching:
Edible gum base 25～30%,
Maltose syrup 20～25%,
Xylitol 35～45%,
Sorbitol 10～20%.
2. preparation method of preventing and treating the chewing gum of oral ulcer after the chemotherapy as claimed in claim 1 comprises following concrete steps:
The first step takes by weighing the chewing gum furnish component in proportion; By edible gum base 25～30%, maltose syrup 20～25%, xylitol 35～45%, the percentage by weight of Sorbitol 10～20% is weighed and is got the raw materials ready;
In second step, mix xylitol and Sorbitol; With xylitol, the Sorbitol mix homogeneously that takes by weighing, put into the sterilization of 80 ℃ of baking ovens after, obtain the mixture of xylitol and Sorbitol;
The 3rd step, softening edible gum base; With the edible gum base thermoplastic that takes by weighing; Simultaneously the maltose syrup that takes by weighing is heated to 100 ℃;
The 4th step, preparation chewing gum batching; With mixture, the 3rd step of second xylitol that obtain of step and Sorbitol obtain softening after edible gum base and be heated to 100 ℃ maltose syrup and evenly mix and obtain the chewing gum batching, cool to room temperature is standby then;
In the 5th step, take by weighing control stomatocace medicine component in proportion; Prevent and treat the recombinant human granulocyte colony stimulating factor that the chewing gum of oral ulcer after the chemotherapy takes by weighing 5～10 milligrams by per 100 grams, 5～10 milligrams folic acid, 5～10 milligrams metronidazole, 20～50 milligrams lignocaine, 5～20 milligrams cimetidine, 2.5～10 milligrams vitamin B2, surplus are the chewing gum batching that made in the 4th step;
In the 6th step, mix control stomatocace medicine and chewing gum batching;
Add folic acid, recombinant human granulocyte colony stimulating factor, metronidazole, lignocaine, cimetidine and the vitamin B2 that takes by weighing in the chewing gum batching that makes in the 4th step, stir evenly and evenly extrude and roll flakiness;
In the 7th step, the thin slice reprocessing molding that the 6th step was obtained obtains the described chewing gum of preventing and treating oral ulcer after the chemotherapy, finally by check, be packaged as finished product.
3. preparation method of preventing and treating the chewing gum of oral ulcer after the chemotherapy as claimed in claim 2 is characterized in that: the chewing gum of oral ulcer is 50 grams/grain after the chemotherapy for preventing and treating of making.
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| CN 201310004799 CN103203011A (en) | 2013-01-07 | 2013-01-07 | Chewing gum for preventing and treating oral ulcer after chemotherapy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583781A (en) * | 2013-11-01 | 2014-02-19 | 阳波 | Coffee-flavored metronidazole chewing gum |
| CN108543061A (en) * | 2018-04-11 | 2018-09-18 | 郑向鹏 | A kind of slow release tablet and preparation method thereof promoting oral cavity and/or Esophageal Mucosa reparation |
| CN110393230A (en) * | 2018-04-24 | 2019-11-01 | 李潺 | A kind of production method of the chewing gum containing mouthwash |
| CN111375067A (en) * | 2020-03-18 | 2020-07-07 | 四川大学 | Chitosan scaffold and preparation method and application thereof |
-
2013
- 2013-01-07 CN CN 201310004799 patent/CN103203011A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583781A (en) * | 2013-11-01 | 2014-02-19 | 阳波 | Coffee-flavored metronidazole chewing gum |
| CN103583781B (en) * | 2013-11-01 | 2015-11-25 | 阳波 | Caf metronidazole chewing gum |
| CN108543061A (en) * | 2018-04-11 | 2018-09-18 | 郑向鹏 | A kind of slow release tablet and preparation method thereof promoting oral cavity and/or Esophageal Mucosa reparation |
| CN110393230A (en) * | 2018-04-24 | 2019-11-01 | 李潺 | A kind of production method of the chewing gum containing mouthwash |
| CN111375067A (en) * | 2020-03-18 | 2020-07-07 | 四川大学 | Chitosan scaffold and preparation method and application thereof |
| CN111375067B (en) * | 2020-03-18 | 2022-02-11 | 四川大学 | Chitosan scaffold and preparation method and application thereof |
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Application publication date: 20130717 |