CN103170057A - Brain state supporting device and method - Google Patents
Brain state supporting device and method Download PDFInfo
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- CN103170057A CN103170057A CN2011104315115A CN201110431511A CN103170057A CN 103170057 A CN103170057 A CN 103170057A CN 2011104315115 A CN2011104315115 A CN 2011104315115A CN 201110431511 A CN201110431511 A CN 201110431511A CN 103170057 A CN103170057 A CN 103170057A
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Abstract
The invention provides a brain state supporting device and method. The brain state supporting device comprises a stimulus applying apparatus, a light detection apparatus, a calculation portion, a determination portion and a stimulus adjusting portion. The calculation portion calculates the total hemoglobin variation amount and the oxygen exchange variation amount according to light information detected by the light detection apparatus; the determination portion applying stimulus to human acupuncture points with electrical signals of preset frequency through the stimulus applying apparatus and determines whether a human brain is in a relaxed mode, focused mode or intermediate mode according to the total hemoglobin variation amount and the oxygen exchange variation amount which are calculated by the calculation portion; and the stimulus adjusting portion adjusts the stimulus amount of the stimulus applying apparatus to human acupuncture points to maintain the brain state mode determined by the determination portion or transfer to other brain state modes. By means of the brain state supporting device and method, the brain state can be known objectively, and the state can be supported, so that the original brain state is maintained, or the state is transferred to other states.
Description
Technical field
The present invention relates to for brain state supportive device and the brain state support method of supporting the human brain state, particularly relate to be used to utilizing near-infrared spectroscopy (NIRS, near-infrared spectroscopy) support so that the brain state can be maintained at relaxed mode, absorbed pattern, or be transferred to brain state supportive device and the brain state support method of other state.
Background technology
, in order to make the brain state be in relaxation state or to be in the state that has improved absorbed power, for example massaged, acupuncture perhaps sleep etc. (following this technology is called prior art 1) in the past.
In addition, following method is disclosed in patent document 1: the whole process apply as the outside stimulus of evaluation object for the subjects before after applying outside stimulus, use near-infrared spectroscopy, measure the concentration change of oxidized form hemoglobin and reduced form hemoglobin etc., afterwards, listen to the subjective comfort when applying described outside stimulus, estimate outside stimulus for the appropriateness of human body according to measured value and subjective comfort level.Refer at this near-infrared spectroscopy, faint near infrared ray (for example 680～1300 nanometers) is shone the oxidized form hemoglobin (Oxy-Hb in the blood in the brain surface (cerebral cortex) of measurement skull next-door neighbour's inboard to brain across skull from scalp; HbO
2) concentration change amount and reduced form hemoglobin (Deoxy-Hb; The method of concentration change amount Hb) (following this technology is called prior art 2).
Patent document 1: TOHKEMY 2002-177282 communique
Summary of the invention
In prior art 1, there are the following problems: can't objectively learn by massage, acupuncture, sleep, in fact which kind of state the brain state is in.
In addition, there are the following problems: massaged or acupuncture after, if nervous or do other thing, its effect will disappear immediately and can't continue.
And, cause treatment because the acupuncture meeting makes bodily injury, so can have the situation of conflict concerning preliminary examination person.
In prior art 2, there are the following problems: although can learn objectively in fact which kind of state the brain state is in, can't support so that the brain state is maintained at original state, or be transferred to other state.
In addition, because there is no to use the oxygen exchange index of the oxygen consumption that is used for the judgement brain, so be difficult to correctly judge the brain state.
The present invention makes in order to address the above problem, purpose is to provide a kind of can learn objectively which kind of state the brain state is in, and can support so that the brain state is maintained at original state, or be transferred to brain state supportive device and the brain state support method of other state.
Brain state supportive device of the present invention is characterised in that to have:
Stimulate applying unit, the human acupoint position signal of telecommunication with preset frequency is stimulated;
Optical detecting unit comprises the illuminating part to the predetermined position of human body irradiation light, and receives the light of outgoing in the human body and the light receiver that detects; And
Apparatus main body is controlled described stimulation applying unit and optical detecting unit, wherein
Described apparatus main body has: computing unit, identifying unit and stimulation adjustment unit, wherein this computing unit basis is by the detected optical information of described optical detecting unit, calculating is as the total hemoglobin variable quantity of the variable quantity sum of the variable quantity of oxidized form hemoglobin and reduced form hemoglobin, and as the oxygen exchange variable quantity of the difference of the variable quantity of the variable quantity of oxidized form hemoglobin and reduced form hemoglobin; This identifying unit applies stimulation to the human acupoint position with the signal of telecommunication of preset frequency by described stimulation applying unit, thereby according to total hemoglobin variable quantity and the oxygen exchange variable quantity that described computing unit calculates, judge whether described human brain state is in relaxed mode, be absorbed at least a pattern in pattern and middle model; This stimulation adjustment unit adjustment applies the quantity of stimulus of stimulation by described stimulation applying unit to described human acupoint position with the signal of telecommunication of preset frequency, make to keep the brain state model of being judged by described identifying unit, or be transferred to other brain state model.
By the human acupoint position that described stimulation applying unit stimulates, it is for example left thumb target section.
By the position that described optical detecting unit detects, it is for example the prefrontal lobe of brain.
Described identifying unit can be by stimulating the described human acupoint position signal of telecommunication with the 1st frequency, and described total hemoglobin variable quantity increases, and in described oxygen exchange variable quantity situation about increasing, judge that the brain state is relaxed mode; By the described human acupoint position signal of telecommunication with the 2nd frequency is stimulated, and described total hemoglobin variable quantity reduces, and in described oxygen exchange variable quantity situation about reducing, judges that the brain state is absorbed pattern; In the situation that beyond these, be judged to be middle model.
Described stimulation adjustment unit can be maintained at relaxed mode with the brain state, or is transferred in the situation of relaxed mode, stimulates by predetermined space for the described human acupoint position signal of telecommunication with the 1st frequency; The brain state is being maintained at absorbed pattern, or is being transferred in the situation of being absorbed in pattern, stimulating by predetermined space for the described human acupoint position signal of telecommunication with the 2nd frequency.
Described the 1st frequency is for example 3Hz, and described the 2nd frequency is for example 10Hz.
Described stimulation adjustment unit can adjust make the brain state transitions more than the quantity of stimulus of the situation that the brain state is maintained at original pattern to the situation of other pattern.
Brain state support method of the present invention is characterized in that, makes the processing of the apparatus main body of carrying out described brain state supportive device.
Can reach following effect according to the present invention:
(1) need not to massage, acupuncture, sleep etc., just can be easily and the brain state that make oneself expectation in the short time.
(2) can learn objectively which kind of state the brain state is in, and the brain state can be maintained at original state, or be transferred to other state.For example, in fatigue and distracting thoughts when many, or in agitation and distracting thoughts when many when maybe can't be absorbed in, if use the present invention that the brain state is made as absorbed pattern, just can realize the brain state that absorbed power relatively improves.
In addition, when having to carry out work, in the situation that be judged to be relaxed mode by the present invention, can forced branch extremely be absorbed in pattern, otherwise, also can be from being absorbed in mode shifts to relaxed mode.
And, can also extend and be absorbed in the state that power improves, or make relaxation state elongated.
Description of drawings
Fig. 1 is the block diagram that the structure of the related brain state supportive device of specific embodiments of the invention is shown.
(A) of Fig. 2 stimulates for illustrating the front view that applies device, (B) for illustrating, stimulation is applied the key diagram that device is installed on the state of thumb, (C) stimulate for illustrating other the front view of example apply device, (D) be installed on the key diagram of the state of thumb for other the example that stimulation is applied device is shown.
Fig. 3 is the flow chart for the work that the brain state supportive device that specific embodiments of the invention are related is described.
(A)-(C) of Fig. 4 is the key diagram for the setting that light detecting device is described.
Fig. 5 is near the curve chart in the variation of the total hemoglobin variable quantity of prefrontal lobe and oxygen exchange variable quantity that applies the core that is illustrated in the palmar side between left thumb the first joint and second joint in the situation of electricity irritation of 3Hz.
The key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe of (A) of Fig. 6 during for quiet before near the electricity irritation that visually represents to apply the core to the palmar side between left thumb the first joint and second joint 3Hz and during the electricity irritation after applying (B) is the key diagram of the variation that visually represents oxygen exchange variable quantity.
Fig. 7 is near the curve chart in the variation of the total hemoglobin variable quantity of prefrontal lobe and oxygen exchange variable quantity that applies the core that illustrates the palmar side between left thumb the first joint and second joint in the situation of electricity irritation of 10Hz.
The key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe of (A) of Fig. 8 during for quiet before near the electricity irritation that visually represents to apply the core to the palmar side between left thumb the first joint and second joint 10Hz and during the electricity irritation after applying (B) is the key diagram of the variation that visually represents oxygen exchange variable quantity.
Fig. 9 is near the curve chart in the variation of the total hemoglobin variable quantity of prefrontal lobe and oxygen exchange variable quantity that applies the core that illustrates the palmar side between left thumb the first joint and second joint in the situation of acupuncture stimulation.
(A) of Figure 10 when visually representing to apply near the core to the palmar side between left thumb the first joint and second joint quiet before acupuncture stimulation, apply acupuncture when stimulating and the key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe of pin after extracting, (B) be the key diagram of the variation that visually represents oxygen exchange variable quantity.
Figure 11 for expression to the curve chart in the variation of the total hemoglobin variable quantity of prefrontal lobe and oxygen exchange variable quantity near the situation that applies acupuncture stimulation the outside from right ring finger the first joint to finger tip.
(A) of Figure 12 for visually represent to when applying quiet before acupuncture stimulation near right ring finger the first joint to the finger tip outside, the key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe when stimulating of applying acupuncture, (B) be the key diagram of the variation that visually represents oxygen exchange variable quantity.
Figure 13 is the block diagram that the related program of specific embodiments of the invention is shown.
Reference numeral
1: brain state supportive device 2: stimulate to apply device 2a: stimulation unit 2b: strap 2c: velcro 3: light detecting device 3a: illuminating part 3b: light receiver 4: apparatus main body 5: input part 6: efferent 7: Department of Communication Force 8: storage part 9: control part 10: display part 11: speaker 12: printing section 13: calculating part 14: detection unit 15: stimulate adjustment part 16: program
The specific embodiment
Referring to accompanying drawing, the specific embodiment of the present invention is described.Fig. 1 is the block diagram that the structure of the related brain state supportive device 1 of specific embodiments of the invention is shown.
As shown in Figure 1, the related brain state supportive device 1 of specific embodiments of the invention has: stimulate to apply device 2, be arranged at human acupoint position (for example left thumb target section), the signal of telecommunication of this position with preset frequency stimulated; Light detecting device 3, has the predetermined position (for example prefrontal lobe of brain) that is arranged at human body, to the illuminating part 3a (light-emitting component) of this predetermined position irradiation light, and receive the light of outgoing in the human body and the light receiver 3b (light receiving element) that detects; And apparatus main body 4.
(A) of Fig. 2 stimulates for illustrating the front view that applies device 2, (B) for illustrating, stimulation is applied the key diagram that device 2 is installed on the state of thumb, (C) stimulate for illustrating other the front view of example apply device 2, (D) be installed on the key diagram of the state of thumb for other the example that stimulation is applied device 2 is shown.
As (A) of Fig. 2 with (B), stimulate to apply device 2 and have with the human acupoint position and join, be used for a pair of stimulation unit 2a that this position is stimulated with the signal of telecommunication of preset frequency and keep stimulation unit 2a, can load and unload the strap 2b that freely is installed on finger etc.
A pair of stimulation unit 2a in the situation that for example finger the interval of about 3-10mm is arranged, as shown in Fig. 2 (B), be set to stimulation target position S is clamped.The interval of stimulation unit 2a is suitably set according to the human acupoint position.
For example velcro 2c (magic tape (registered trade mark)) is installed at the both ends of strap 2b, after waiting by finger on strap 2b volume, velcro 2c is pasted mutually, stimulation can be applied device 2 and be set to be fixed on finger etc.
In addition, as (C) of Fig. 2 with (D), vertical width of strap 2b is broadened, with a pair of stimulation unit 2a devices spaced apart ground configuration on oblique direction.
Light detecting device 3 for example has the assembling band that is installed on the human body predetermined position, is with in this assembling one or more illuminating part 3a and light receiver 3b are separated predetermined space ground configuration.
Apparatus main body 4 is controlled to stimulate and is applied the work of device 2 and light detecting device 3, and carries out input and output, computing and the storage of various data, has input part 5, efferent 6, Department of Communication Force 7, storage part 8 and control part 9.
The input part 5 various data of input are such as being keyboard, numeric keypad (ten key), mouse, badge card card reader and OCR (optical profile type character reader) etc.
The various data of efferent 6 output have the speaker 11 of display part 10, output sound data of the monitor that shows various data, display etc. and the printing section 12 of printing the printer etc. of various data.
Department of Communication Force 7 carries out receiving for the transmission of the various data that are connected with communication networks such as the Internet (according to the data transmission network of TCP/IP (TCP/IP)), LAN (LAN), such as being modem, terminal adapter, router, DSU (DSU) etc.
Control part 9 has: calculating part 13, detection unit 14 and stimulate adjustment part 15, wherein calculating part 13 bases are by the detected optical information of light detecting device 3, calculating is as the total hemoglobin variable quantity of the variable quantity sum of the variable quantity of oxidized form hemoglobin and reduced form hemoglobin, and as the oxygen exchange variable quantity of the difference of the variable quantity of the variable quantity of oxidized form hemoglobin and reduced form hemoglobin; Detection unit 14 applies 2 pairs of devices human acupoint position by stimulation and applies stimulation with the signal of telecommunication of preset frequency, thereby according to total hemoglobin variable quantity and the oxygen exchange variable quantity that calculating part 13 calculates, judge whether the human brain state is in relaxed mode, be absorbed at least a pattern in pattern and middle model; Stimulate adjustment part 15 to adjust to apply 2 pairs of devices human acupoint position by stimulation to apply the quantity of stimulus of stimulation with the signal of telecommunication of preset frequency, make and keep the brain state model of being judged by detection unit 14, or be transferred to other brain state model.
Detection unit 14 is by stimulating the human acupoint position signal of telecommunication with the 1st frequency (for example 3Hz), and the total hemoglobin variable quantity increases, and in oxygen exchange variable quantity situation about increasing, judges that the brain state is relaxed mode; By the human acupoint position signal of telecommunication with the 2nd frequency (for example 10Hz) is stimulated, and described total hemoglobin variable quantity reduces, and in described oxygen exchange variable quantity situation about reducing, judges that the brain state is absorbed pattern; In the situation that beyond these, be judged to be middle model.
Stimulate adjustment part 15 that the brain state is being maintained at relaxed mode, or be transferred in the situation of relaxed mode, stimulate by predetermined space for the human acupoint position signal of telecommunication with the 1st frequency (for example 3Hz); And the brain state is being maintained at absorbed pattern, and or be transferred in the situation of being absorbed in pattern, stimulate by predetermined space for the human acupoint position signal of telecommunication with the 2nd frequency (for example 10Hz).
Stimulate adjustment part 15 to adjust to make the brain state transitions more than the quantity of stimulus of the situation that the brain state is maintained at original pattern to the situation of other pattern.
In addition, the numerical value of the frequency of the signal of telecommunication that be used for to stimulate is not limited to this for illustrating.
Fig. 3 is the flow chart for the work that the brain state supportive device 1 that specific embodiments of the invention are related is described.
At first, stimulation is applied device 2 and be arranged at human acupoint position (for example left thumb target section) (step S1).
Next, light detecting device 3 is arranged at human body predetermined position (for example prefrontal lobe of brain) (step S2).
Next, carry out for the preparation (step S3) of judging the brain state.
In this step S3, apply the stimulation 5-10 second of 3Hz, determine the minimum stimulus intensity that the skin of left thumb target section feels slightly, apply the stimulation 5-10 second of 3Hz, determine that the dermal sensation of left thumb target section to the highest stimulus intensity of pain, calculates centre 50% stimulus intensity that 3Hz stimulates according to the following formula.
The calculating of centre 50% stimulus intensity that 3Hz stimulates=(minimum stimulus intensity+the highest stimulus intensity)/2
In addition, apply the stimulation 5-10 second of 10Hz, determine the minimum stimulus intensity that the skin of left thumb target section feels slightly, apply the stimulation 5-10 second of 10Hz, determine that the dermal sensation of left thumb target section to the highest stimulus intensity of pain, calculates centre 50% stimulus intensity that 10Hz stimulates according to the following formula.
The calculating of centre 50% stimulus intensity that 10Hz stimulates=(minimum stimulus intensity+the highest stimulus intensity)/2
Maximal stimulus intensity set electricity irritation voltage, electric current value and carry out.
Next, judge brain state (step S4) by detection unit 14.At this, will be defined as relaxed mode (R pattern) with the brain response of the stimulation gained of 3Hz to left thumb target section, brains loosens and is in calm state when this pattern.In addition, will be defined as absorbed pattern (B pattern) with the brain response of the stimulation gained of 10Hz, when being in this pattern, brains is worked, and is absorbed in power and faculty of understanding and improves, and is in the state that is suitable for learning etc.
In this step S4, left thumb target section was stimulated the stimulation of the middle stimulus intensity 3Hz that determines in abovementioned steps S2 to stop in-30 seconds with 30 seconds stimulated the pattern that stopped in-30 seconds to apply in-30 seconds.
If afterwards less than reaction, being judged to be, stimulation in 30 seconds has been in strong R pattern.
If R pattern reaction judges it is the rudimentary of R pattern, or B pattern, middle model.
In addition, thumb target section stimulated the stimulation of the middle stimulus intensity 10Hz that determines in described step S2 to stop in-30 seconds with 30 seconds and stimulated the pattern that stopped in-30 seconds to apply in-30 seconds left.
If afterwards less than reaction, being judged to be, stimulation in 30 seconds has been in strong B pattern.
If B pattern reaction judges it is the rudimentary of B pattern, or R pattern, middle model.
Result of determination is shown in the display part 10 of monitor, display etc., or passes through speaker 11 by voice output.In addition, result of determination can also be printed by printing section 12, or carrying out data by Department of Communication Force 7 via network sends.
Next, stimulating adjustment part 15 to carry out the adjustment (step S5) of quantity of stimulus.
In this step S5, has following situation: 1) be judged to be in the situation of B pattern by detection unit 14, be adjusted into the situation that is transferred to the R pattern; 2) be judged to be in the situation of R pattern by detection unit 14, be adjusted into the situation that is maintained at the R pattern; 3) be judged to be in the situation of B pattern by detection unit 14, be adjusted into the situation that is maintained at the B pattern; And 4) be judged to be in the situation of R pattern by detection unit 14, be adjusted into the situation that is transferred to the B pattern.
The selection of above any situation can both be carried out via input part 5, and the adjustment of various situations is for example carried out as following.
1) situation of B → R (transfer)
50% quantity of stimulus of the value that the 3Hz that will determine in step S3 stimulates applies 60 seconds, had a rest 30 seconds, and then 75% quantity of stimulus is applied 60 seconds, has a rest 30 seconds.If be not transferred to the R pattern, further 100% quantity of stimulus is applied 60 seconds.
Like this quantity of stimulus is upgraded, and propelling is to the transfer of R pattern.
2) situation of R → R (keeping)
25% quantity of stimulus of the value that the 3Hz that will determine in step S3 stimulates applies 30 seconds, had a rest 30 seconds, and then 25% quantity of stimulus is applied 30 seconds, has a rest 30 seconds, and the quantity of stimulus with 25% applies 30 seconds.
Apply like this intermittently same stimulation, and keep the R pattern.
3) situation of B → B (keeping)
25% quantity of stimulus of the value that the 10Hz that will determine in step S3 stimulates applies 30 seconds, had a rest 30 seconds, and then 25% quantity of stimulus is applied 30 seconds, has a rest 30 seconds, and the quantity of stimulus with 25% applies 30 seconds.
Apply like this intermittently same stimulation, and keep the B pattern.
4) situation of R → B (transfer)
50% quantity of stimulus of the value that the 10Hz that will determine in step S3 stimulates applies 60 seconds, had a rest 30 seconds, and then 75% quantity of stimulus is applied 60 seconds, has a rest 30 seconds.If be not transferred to the B pattern, further 100% quantity of stimulus is applied 60 seconds.
Like this quantity of stimulus is upgraded, and propelling is to the transfer of B pattern.
In addition, the adjustment of above-mentioned quantity of stimulus is an example and be not limited to this.
Next, in order to confirm that brain state supportive device 1 involved in the present invention is useful, the experiment of being undertaken by the present inventor is described.
In this experiment, (Shimadzu Seisakusho Ltd. makes: the detection and the record that FOIRE3000) have carried out corticocerebral Hb concentration to use near-infrared spectral photometry device.
Hemoglobin be sampled as 70ms.
The hemoglobin that records is oxidized form hemoglobin (oxy-Hb) and deoxidation (reduced form) hemoglobin (deoxy-Hb).
According to the variable quantity of this value, calculate total hemoglobin concentration change amount (total-Hb: the summation of oxidation and deoxidation) with oxygen concentration variable quantity (ScO according to following calculating formula
2), as the index of the COE of brain reaction.
Total hemoglobin (concentration) variable quantity [Total hemoglobin]=[Oxyhemoglobin]+[Deoxyhemoglobin]
Oxygen exchange (concentration) variable quantity (as one of inventor's the brain function index that rattan is found that adds) [ScO
2]=[Oxyhemoglobin]-[Deoxyhemoglobin]
The functional parameter that is even more important is, ScO
2Minimizing=oxygen consumption, protoxydic position is even more important.
The total hemoglobin variable quantity represents to be clipped in the change of the erythrocytic quantity in the voxel (voxel) in photo measure zone of irradiation and detector probe, if increase represent that erythrocyte increases, if reduce represent the erythrocyte minimizing.
Oxygen exchange variable quantity represents that the oxygen concentration in blood capillary changes, if increase mean that in blood vessel, oxygen increases, if reduce mean that endovascular oxygen reduces.The meaning that in blood vessel, oxygen increases means from tremulous pulse has supplied with oxygen containing erythrocyte.The meaning of endovascular hypoxia is, expression is because neurocyte has consumed oxygen, and the oxygen in blood capillary has been consumed.
Experimental result uses waveform to show and reflection (mapping) shows these two kinds.Waveform shows that the expression seasonal effect in time series changes, and the integrated value of stimulation time is drawn in the reflection demonstration.
(A)-(C) of Fig. 4 is the key diagram for the setting that light detecting device 3 is described.Light detecting device 3 is arranged and is configured with high-density probe, is configured to the brodmann's area (Brodmann ' s Areas) 10th district (prefrontal lobe) shown in (A) of coverage diagram 4.
The illuminating part 3a of light detecting device 3 and light receiver 3b are with the arranged spaced shown in Fig. 4 (B), along configuring 3 illuminating part 3a and 3 light receiver 3b from right brain to left brain, the total hemoglobin variable quantity of the measuring point that amounts to 5 places of measurement 24ch-28ch and oxygen exchange the variation of variable quantity as shown in Fig. 4 (C).
Fig. 5 is near the curve chart that applies the core that illustrates the palmar side between left thumb the first joint and second joint in the situation of electricity irritation of 3Hz in the variation of the total hemoglobin variable quantity of prefrontal lobe and oxygen exchange variable quantity.At this, transverse axis is time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 30 seconds.
The key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe of (A) of Fig. 6 during for quiet before near the electricity irritation that visually represents to apply the core to the palmar side between left thumb the first joint and second joint 3Hz and during the electricity irritation after applying (B) is the key diagram of the variation that visually represents oxygen exchange variable quantity.
According to Fig. 5 and Fig. 6 as seen, under the electricity irritation of 3Hz, observed the variation in the timing of the increase of the increase of total hemoglobin variable quantity on a large scale and oxygen exchange variable quantity.Especially in prefrontal lobe, obviously assert this variation.
Fig. 7 is near the curve chart in the variation of the total hemoglobin variable quantity of prefrontal lobe and oxygen exchange variable quantity that applies the core that illustrates the palmar side between left thumb the first joint and second joint in the situation of electricity irritation of 10Hz.At this, transverse axis is time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 30 seconds.
(A) of Fig. 8 during for quiet before near the electricity irritation that visually represents to apply the core to the palmar side between left thumb the first joint and second joint 10Hz with apply after electricity irritation the time the key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe, (B) be the key diagram of the variation that visually represents oxygen exchange variable quantity.
According to Fig. 7 and Fig. 8 as seen, under the electricity irritation of 10Hz, observed the variation in the timing of the minimizing of the minimizing of total hemoglobin variable quantity on a large scale and oxygen exchange variable quantity.
Like this left thumb target section being applied respectively in the situation of the signal of telecommunication of 3Hz and 10Hz, is antipodal result at the oxygen metabolism of prefrontal lobe, under 10Hz, suboxides occurs, and increases and high oxidation at the next generation blood flow of 3Hz.
In addition, hinted the frequency that depends on electricity irritation, prefrontal lobe changes sensitively, and cognitive function is impacted.
Next, as the reference that is used for comparison of the present invention, the experiment when carrying out acupuncture stimulation describes.
Fig. 9 is near the curve chart that applies the core that illustrates the palmar side between left thumb the first joint and second joint in the situation of acupuncture stimulation in the variation of the total hemoglobin variable quantity of prefrontal lobe and oxygen exchange variable quantity.
At this, transverse axis is time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 180 seconds.
(A) of Figure 10 when visually representing to apply near the core to the palmar side between left thumb the first joint and second joint quiet before acupuncture stimulation, the key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe after extracting with pin when stimulating of applying acupuncture, (B) for representing that visually oxygen exchanges the key diagram of the variation of variable quantity.
According to Fig. 9 and Figure 10 as seen, under acupuncture stimulation, from rotation begins 30～45 seconds, total hemoglobin variable quantity and oxygen exchange variable quantity all increased, continuous decrease afterwards, and this is considered to the main effect of acupuncture.
In addition, 10Hz produces and is identified close to the repeatability of the state of acupuncture stimulation than 3Hz.
Figure 11 illustrates exchange the curve chart of the variation of variable quantity near the situation that applies acupuncture stimulation the outside from right ring finger the first joint to finger tip at the total hemoglobin variable quantity of prefrontal lobe and oxygen.At this, transverse axis is time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 180 seconds.
(A) of Figure 12 for visually represent to when applying quiet before acupuncture stimulation near right ring finger the first joint to the finger tip outside, the key diagram in the variation of the total hemoglobin variable quantity of prefrontal lobe when stimulating of applying acupuncture, (B) be the key diagram of the variation that visually represents oxygen exchange variable quantity.
According to Figure 11 and Figure 12 as seen, when causing pain to strengthen due to the rotatory stimulation of pin, in the part of prefrontal lobe, change high oxidation into, blood flow reduces, obviously different from the brain response that stimulation to left thumb causes.
Figure 13 is the block diagram that the related program of specific embodiments of the invention is shown.
As shown in figure 13, the related program 16 of specific embodiments of the invention is controlled the apparatus main body 4 of the related brain state supportive device 1 of specific embodiments of the invention, the processing that the apparatus main body 4 that makes computer carry out above-mentioned explanation carries out.
This program 16 both can be recorded on the recording mediums such as disk, CD-ROM, semiconductor memory, also can be via downloaded.
The invention is not restricted to the above-mentioned specific embodiment, in the scope of the technology item of putting down in writing, various changes can be arranged in claims.For example as apparatus main body 4, can replace isolated plant with personal computer or information terminal apparatus etc.
Brain state supportive device 1 of the present invention and program 16 are used for utilizing near-infrared spectroscopy (NIRS) and support so that the brain state can be maintained at relaxed mode, absorbed pattern, or are transferred to other state.
Claims (8)
1. brain state supportive device is characterized in that having:
Stimulate applying unit, the human acupoint position signal of telecommunication with preset frequency is stimulated;
Optical detecting unit comprises the illuminating part to the predetermined position of human body irradiation light, and receives the light of outgoing in the human body and the light receiver that detects; And
Apparatus main body is controlled described stimulation applying unit and optical detecting unit, wherein
Described apparatus main body has: computing unit, identifying unit and stimulation adjustment unit, wherein this computing unit basis is by the detected optical information of described optical detecting unit, calculating is as the total hemoglobin variable quantity of the variable quantity sum of the variable quantity of oxidized form hemoglobin and reduced form hemoglobin, and as the oxygen exchange variable quantity of the difference of the variable quantity of the variable quantity of oxidized form hemoglobin and reduced form hemoglobin; This identifying unit applies stimulation to the human acupoint position with the signal of telecommunication of preset frequency by described stimulation applying unit, thereby according to total hemoglobin variable quantity and the oxygen exchange variable quantity that described computing unit calculates, judge whether described human brain state is in relaxed mode, be absorbed at least a pattern in pattern and middle model; This stimulation adjustment unit adjustment applies the quantity of stimulus of stimulation by described stimulation applying unit to described human acupoint position with the signal of telecommunication of preset frequency, make to keep the brain state model of being judged by described identifying unit, or be transferred to other brain state model.
2. brain state supportive device according to claim 1 is characterized in that:
The human acupoint position that is stimulated by described stimulation applying unit is left thumb target section.
3. brain state supportive device according to claim 1 and 2 is characterized in that:
Position by described optical detecting unit detects is the prefrontal lobe of brain.
4. the described brain state of any one supportive device according to claim 1～3 is characterized in that:
Described identifying unit is by stimulating the described human acupoint position signal of telecommunication with the 1st frequency, and described total hemoglobin variable quantity increases, and in described oxygen exchange variable quantity situation about increasing, judges that the brain state is relaxed mode; By the described human acupoint position signal of telecommunication with the 2nd frequency is stimulated, and described total hemoglobin variable quantity reduces, and in described oxygen exchange variable quantity situation about reducing, judges that the brain state is absorbed pattern; In the situation that beyond these, be judged to be middle model.
5. the described brain state of any one supportive device according to claim 1～4 is characterized in that:
Described stimulation adjustment unit is being maintained at relaxed mode with the brain state, or is transferred in the situation of relaxed mode, stimulates by predetermined space for the described human acupoint position signal of telecommunication with the 1st frequency; The brain state is being maintained at absorbed pattern, or is being transferred in the situation of being absorbed in pattern, stimulating by predetermined space for the described human acupoint position signal of telecommunication with the 2nd frequency.
6. according to claim 4 or 5 described brain state supportive devices is characterized in that:
Described the 1st frequency is 3Hz, and described the 2nd frequency is 10Hz.
7. the described brain state of any one supportive device according to claim 1～6 is characterized in that:
Described stimulation adjustment unit adjust make the brain state transitions more than the quantity of stimulus of the situation that the brain state is maintained at original pattern to the situation of other pattern.
8. brain state support method is characterized in that:
Make enforcement of rights require the processing of the apparatus main body of the described brain state of any one supportive device in 1～7.
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| CN109069072A (en) * | 2016-02-08 | 2018-12-21 | 纽洛斯公司 | fraud detection system and method |
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| US5135468A (en) * | 1990-08-02 | 1992-08-04 | Meissner Juergen P | Method and apparatus of varying the brain state of a person by means of an audio signal |
| US6986747B2 (en) * | 2002-01-29 | 2006-01-17 | Johnson & Johnson Consumer Companies | Method of measuring the stress or relaxation level of a mammal |
| US20070167690A1 (en) * | 2005-12-19 | 2007-07-19 | Olemi Trading Inc. | Mind-body correlation data evaluation apparatus and method of evaluating mind-body correlation data |
| CN101044976A (en) * | 2006-03-31 | 2007-10-03 | 合世生医科技股份有限公司 | Method and apparatus for measuring blood pressure by using blood oxygen concentration and electrocardiograph |
| US20080269832A1 (en) * | 2007-04-26 | 2008-10-30 | The Hong Kong Polytechnic University | Device and method for sleep apnea management using SpO2 |
| CN201147301Y (en) * | 2007-11-22 | 2008-11-12 | 河南华南医电科技有限公司 | Sleep respiratory disturbance detecting device |
| US20090171164A1 (en) * | 2007-12-17 | 2009-07-02 | Jung Edward K Y | Methods and systems for identifying an avatar-linked population cohort |
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| CN109069072A (en) * | 2016-02-08 | 2018-12-21 | 纽洛斯公司 | fraud detection system and method |
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