CN103170024B - Normovolemic dilution autoblood collection and reinfusion system, and normovolemic dilution autoblood collection and reinfusion device - Google Patents
Normovolemic dilution autoblood collection and reinfusion system, and normovolemic dilution autoblood collection and reinfusion device Download PDFInfo
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Abstract
The invention discloses a normovolemic dilution autoblood collection and reinfusion system and a normovolemic dilution autoblood collection and reinfusion device. The system is composed of a pipeline system, a dynamic system, a monitoring and alarming system, a blood-storage system and a computer control platform. When the system works, autoblood evenly blended with anticoagulation is stored in a blood-storage bag, at the same time diluent is infused in a blood vessel, and thus the purposes of blood sampling and hemodilution are achieved; when needed, the stored autoblood is infused back to a patient, and thus the purpose of reducing loss of hemoglobin is achieved. The system is controlled and operated by a computer, the monitoring and alarming system is arranged in the system, and thus safe operation is guaranteed. The dynamic system in the system can be controlled independently to conduct liquid infusion, and a pressure monitoring device can supply pressure data. The normovolemic dilution autoblood collection and reinfusion device is divided into a main engine and a control panel and is composed of a pump component, a mentoring component, a pipeline control card component, a control panel and a table. By means of the normovolemic dilution autoblood collection and reinfusion system and the normovolemic dilution autoblood collection and reinfusion device, normovolemic dilution autoblood collection and reinfusion can be performed automatically and safely, the workload of doctors is reduced, efficiency is improved, risk is avoided, and further the normovolemic dilution autoblood collection and reinfusion system and the normovolemic dilution autoblood collection and reinfusion device can be used as a infusion control platform and for pressure monitoring.
Description
Technical field
The present invention relates to a kind of system and the relevant apparatus that are completed autologous blood collection and feedback by Isovolumic hemodilution method, and this system can be utilized to build carry out peri-operative central venous infusion management simultaneously and control.
Background technology
Blood used in clinic relates generally to autologous blood and foreign body blood two aspect.Infusion foreign body blood may bring a lot of problem to patient, and as allergy, heating, disease propagation etc., no matter be doctor or patient, family members wish to avoid or reduce infusion foreign body blood as far as possible, this is the important clinical problem of medical circle discussion and research for a long time.Meanwhile, amount of bleeding and allogeneic transfusion amount are one of major criterions evaluating medical level, and less application foreign body blood indicates more excellent medical skill and medical integrated management usually.In addition, foreign body blood is a kind of non-renewable medical resource, and it gathers, preserve and use has been come by the mechanism of specialty, needs to employ a large amount of social resources, also needs the support energetically of a large amount of volunteer doner of blood simultaneously.Foreign body blood is the important leverage resource that curative activity is carried out smoothly; once be subject to the situation impacts such as blood donor's minimizing, blood used in clinic increase, emergency burst; clinical position will be subject to severe jamming; suspend because of " blood is waste " or stops necessary curative activity and happen occasionally, this brings serious threat to the patient needing input foreign body blood to save health and lives.It is alleviate foreign body blood key problem in short supply that reasonable employment and minimizing use.As can be seen here, it is not only medical problem that foreign body blood uses, and Ye Shi social problem, economic problems, concern medical safety, have been subject to the extensive concern of the whole society.
In surgical procedures; autotransfusion, to reduce that hemorrhage and intraoperative hemorrhage reclaims be the important technique measure of blood samples of patients protection; everybody recognizes; right combination applies above many kinds of measures can reduce the use even avoiding foreign body blood; the development of correlative technology field will produce actively impact to blood used in clinic problem, and the entirety promoting medical level improves.
Autotransfusion is very early by everybody is paid close attention to, just started to adopt before 170 years, but promoted the use of gradually because of the worry to post-transfusion hepatitis after 1970, the research of association area also deepens continuously, wish that it becomes the effective means reducing foreign body blood blood transfusion.At present, autotransfusion mainly contains two kinds of modes, and one is that preoperative autologous blood is preserved, and another kind is the autologous blood blood transfusion of acute Isovolumic hemodilution before operation starts.Front a kind of mode was once widely applied at western developed country the eighties, but due to multiple unfavorable reasons such as flow process is complicated, medical treatment input is more, cost performance is not high, blood loss, application obviously reduces, 2.5% of current Jin Zhan U.S. blood drawing total amount, therefore, everybody places on Isovolumic hemodilution autotransfusion mode hope.
The present invention relates generally to system, technology and the device that the autologous blood of Isovolumic hemodilution is preserved and fed back, and manage based on the peri-operative central venous infusion of this system, control system.It is at the anesthesia initial stage that Isovolumic hemodilution method gathers autologous blood, the autoblood that operation starts front drain setting unit is filled with in the blood storage bag of anticoagulant to special, give crystal or the colloidal solution of the suitable volume of patient's infusion simultaneously, stable to ensure that blood volume in patient body is stablized with life state, patient hemoglobin concentration is diluted to setting level, if operation start after hemorrhage cause hemoglobin concentration decline reach estimate feed back concentration time will start intraoperative autologous blood transfusion, estimate to feed back concentration if hemoglobin concentration does not reach all the time, will before operation terminates by intraoperative autologous blood transfusion to patient, reach minimizing operative hemorrhage, promote the therapeutic goal of hemoglobin after surgery concentration.A large amount of clinical experiments is verified; Isovolumic hemodilution method is adopted to complete autologous blood collection; owing to having made blood Macrodilution before the start of the surgery; reduce the concentration of hemoglobin in unit volume blood; decrease the hemoglobin loss that intraoperative hemorrhage causes; reach the object of blood conservation, reduce infusion rate or the infusion amount of foreign body blood, contribute to avoiding or reducing the various risks using foreign body blood to bring.
Along with the further investigation about body compensation after Isovolumic hemodilution, find that body can tolerate acute Isovolumic hemodilution to a great extent by multiple self-regulation mode, operating process is that safety is controlled, even if be also the same for elderly patient and cardiovascular patient.Research also finds; the body compensatory mechanisms such as heart stroke increases, blood viscosity declines, hemoglobin oxygen dissociation curve moves to right are caused after hemodilution; body microcirculating state improves; perfused tissue amount increases; help the protection of the important organs such as Rhizoma Atractylodis Macrocephalae midbrain, lung, heart, but harmful effect is not caused to blood coagulation system.Therefore, Isovolumic hemodilution not only can reach the object of blood conservation, or a kind of effective means of perioperative multiple organ protection.Therefore, in view of the safety of acute Isovolumic hemodilution method, and the effectiveness in blood conservation, Organoprotective, this method is written in autotransfusion guide.
Although Isovolumic hemodilution autotransfusion mode is worthy to be popularized, clinical practice situation is undesirable, the risk that main cause is inconvenience in practical operation, the impact that causes anesthesia management and misoperation cause.At present, owing to lacking the higher dilution of Automated condtrol Cheng Du, blood sampling apparatus, implementation process relies on manual operation completely, and blood sampling, blood transfusion path are also not quite similar, and efficiency is very low.At present, blood sampling depends on gravity drainage mode, if adopt Vein Tube blood sampling tube, often gather 2 unit whole bloods and about need 15 minutes, efficiency is not high, and extend anesthesia duration, wait for operating time, amount of dilution is larger, and time expand is more; If adopt arterial intubation blood sampling tube, though blood sampling speed is improved, Arterial system rapid, high volume is lost blood, from vein rapid, high volume infusion fluid, easily cause hemodynamics sharply to change, steadily, there is relevant organ functional lesion in the patient easily bringing out pulmonary insufficiency in impact anesthesia.Meanwhile, because blood to need by long and narrow pipeline drainage to close in the blood storage bag of ground level, to there is no anticoagulant therebetween and be mixed into, easily cause thrombosis, cause blood loss and blood transfusion risk.In addition, because blood collection procedure must be completed by anaesthetist, anaesthetist is while control blood sampling, transfusion speed coupling, want continual and rock blood storage bag, ensure the abundant mixing of blood and anticoagulant, meanwhile also will drop into energy for anesthesia management and anesthesia monitoring, work load rolls up, distraction, easily causes work to slip, and causes risk.Such as, if observed not in time, drainage volume exceedes the standard of blood storage bag, will cause anticoagulant relative deficiency, brings out thrombosis in storage blood bag.And for example, because blood sampling efficiency is low, length consuming time, when a variety of causes requires that operation starts as early as possible, blood sampling work will have to stop, and not reach predetermined dilution rate, affect therapeutic effect.
In order to improve autologous blood acquisition mode, improve collecting efficiency, traditional gravity drainage mode must be abandoned, rely on automation equipment, the amount of the autologous blood collection of accurate control, diluent infusion and speed, raise the efficiency, and reduces the impact on patient's recurrent state and organ function, and fully anaesthetist is freed from loaded down with trivial details operation, avoid human error.At present, the U.S. has inventor to devise the simple mechanical type negative pressure device improving blood sampling efficiency, only relates to the change of drainage way, and the improvement controlled entirety is very limited.
At present, ripe system, technology, device is not still had clinically for automatization's management and control field of Isovolumic hemodilution autotransfusion method.Central vein catheter is the transfusion path of big-and-middle-sized operation necessity, associative operation is the important step of anesthesia management, the collection of Isovolumic hemodilution autologous blood, the feedback system of the present invention's design rely on special two-chamber central vein catheter to carry out blood collection and feedback, on the basis not increasing anesthetist's operation bidirectional, contribute to control and the automatization of adopting transfusion procedure, the transfusion power-equipment provided by this system and control appliance can also complete the control of infusion flow to multiple medicine and flow velocity, also can be used for the monitoring of central venous pressure.This invention designed system can promote clinical expansion and the use of this autotransfusion mode, is applied to perioperative fluid infusion management and central venous pressure monitoring simultaneously, can completes Autoblood collection, blood transfusion and peri-operative central venous infusion.
Summary of the invention
In view of current Isovolumic hemodilution clinically adopts the gravity drainage mode of poor efficiency, rely on manual operation and control completely, multiple unfavorable factor affects popularization and the safety applications of the method, for this reason, main purpose of the present invention is to provide the system that automatization completes Isovolumic hemodilution Autoblood collection, blood transfusion, and the device matched, comprise pipe-line system, dynamical system, monitor and alarm system, blood storage system and computer parametric controller.
Blood collection of the present invention and diluent infusion rely on the Double-laparoscope central venous catheter of inserting patient's central vein, blood can be drawn or feedback by the side conduction hole of conduit by a relatively thick tube chamber, and diluent or medicine can be injected central vein by the stomidium of catheter tip by a relatively thin tube chamber.Thicker tube chamber can ensure to provide desirable blood drainage amount under lower tube chamber negative pressure state, provides higher blood sampling efficiency and the protection of sufficient blood cell.
The Double-laparoscope central venous catheter pipeline supporting with main frame is connected.The pipeline that blood is drawn or fed back is called transducer potector, and far-end is connected with blood storage bag, and centre is connected with two secondary duct by side opening, and secondary duct far-end connects anticoagulant syringe and transfusion bag; Corresponding, the pipeline that diluent injects is called liquid line, and far-end is connected with diluent reservoir bag, and centre is connected with secondary duct by side opening, and secondary duct far-end connects paramedicines syringe.
In pipeline, the driving of liquid relies on the dynamical system be made up of 4 pump installations to complete, occlusion pump and each two of standardize solution infusion pump, the flow velocity of every platform pump, flow or flow to by the computer system control of parametric controller.
The traveling region of pipeline in main frame is provided with many places mechanicalness control card, and control card is closed will hinder stopped pipe road, stop the flowing of liquid in pipeline, and the keying of control card is controlled according to different operation modes and monitoring, alarming situation by parametric controller.Arrange pressure and gas monitoring component in pipeline traveling process, monitoring device data are sent to parametric controller, parametric controller according to the keying of data cases feedback control many places pipeline control card, to ensure to take a blood sample and the safety of transfusion procedure.
Gather blood to mix with anticoagulant in transducer potector, mix in occlusion pump extrusion process, finally be stored in blood storage bag, blood storage bag is placed in the storage blood storehouse of laying shaking table, shaking table is controlled by parametric controller, start uninterruptedly to rock to blood transfusion terminal procedure in blood sampling, promote anticoagulant and blood mixing, thrombosis in preclude blood.
Control panel is formed by setting adjustment member, display screen and computer.By the button on regulable control panel, doctor can set the concrete numerical value such as total blood sampling volume, blood sampling speed, diluent infusion total amount, diluent flow velocity according to blood sampling prediction scheme, can also arrange pressure alarm.Doctor can be preset in selection equipment different working modes, as blood sampling pattern, blood transfusion pattern, infusion mode etc., in different modes, occlusion pump turns to, pipeline control card opens and closes and pre-sets, and conveniently can start relevant action.Display is used for showing the parameters, alarm condition and the equipment running status that need to observe or adjust.Computer system, according to program prepared in advance, completes data input, computing, output, controls the running of whole equipment.
By the autologous blood collection of the Isovolumic hemodilution formed with upper part, feedback system, can complete adopt transfusion procedure setting, enforcement, monitoring and management and control, the operation of maximum minimizing doctor and distraction, complete accurate data setting and scheme implementation, and give Real-Time Monitoring, send danger warning and stop running, to Isovolumic hemodilution autologous adopt blood transfusion procedure provide convenience, safety guarantee.
Meanwhile, in blood sampling, time beyond transfusion procedure, system can control separately four pump installations, foundation transfusion speed is set, complete the quantitative infusion of traditional fluid infusion and special medicine, carry out peri-operative central venous infusion.Owing to providing, gas enters, pressure alarm, and infusion process will become safer.The pressure sensor device arranged in system not only can provide pressure monitoring in blood collection procedure and warning, can also provide central venous pressure force data, carry out the hemodynamic monitoring in anaesthesia process.
Beneficial effect of the present invention is.
1, invent the autologous blood collection of Isovolumic hemodilution of design, feed back system, can according to Isovolumic hemodilution prediction scheme setting blood sampling flow rate and dilution flow rate flow, accurately control dilution, minimizing operates hemodynamic impact.
2, system is according to setting, completes the accurately control automatically of blood sampling and transfusion procedure, reduces operation and the distraction of Anesthetist, ensure operation and Anesthetic safety.
3, system has multiple default operating mode available, facilitates doctor's adjusting device quickly.
4, pressure, the gas alarm parts of Operation system setting, by computer system automatic open close pipeline control card, ensure the processing safety under different mode.
5, the Double-laparoscope central venous catheter that system adopts can be used for the management of Traditional center venous transfusion, does not additionally increase anesthesia and puts pipe operation.Owing to can control separately four infusion pump, system also can be taken into account and form medium-sized vein transfusion management and control center, facilitates anesthesia management.
6, system provides central venous pressure force data, carries out the hemodynamic monitoring in anaesthesia process.
Accompanying drawing explanation
Accompanying drawing described herein is used to provide a further understanding of the present invention, and form a application's part, schematic description and description of the present invention, for explaining the present invention, does not form inappropriate limitation of the present invention.
Fig. 1 the present invention adopt two-chamber central vein catheter structure chart and insert schematic diagram.
Fig. 2 host structure chart of the present invention.
Fig. 3 control panel structure chart.
Fig. 4 system operating mode figure.
Operating diagram under Fig. 5 main frame dilution blood sampling mode state.
Operating diagram under Fig. 6 main frame pipeline protection maintenance state.
Operating diagram under Fig. 7 main frame infusion mode state.
Operating diagram under Fig. 8 main frame blood recovery mode state.
Fig. 9 occlusion pump safety monitoring warning system hierarchical schema figure.
Negative pressure under Figure 10 main frame dilution blood sampling mode state, high pressure, air inlet are reported to the police and are shut down schematic diagram.
High pressure under Figure 11 main frame infusion mode state, air inlet are reported to the police and are shut down schematic diagram.
High pressure under Figure 12 main frame blood transfusion mode state, air inlet are reported to the police and are shut down schematic diagram.
Figure 13 computer controls schematic flow sheet
101-central venous catheter in figure, 102-stomidium, 103-side opening, 104-fixed-wing, 105-transducer potector branch, 106-liquid line branch, 107-transducer potector, 108-liquid line, 109-pipe joint, 110-standardize solution pump branch line A, 111-standardize solution pump branch line B, 112-infusion connecting tube road A, 113-infusion connecting tube road B, 114-blood storage bag connecting line, 115-blood storage bag, 116-diluent bag, 117-transfusion bag, 118-anticoagulant syringe, 119-paramedicines syringe, 201-occlusion pump A, 202-occlusion pump B, 203-standardize solution infusion pump A, 204-standardize solution infusion pump B, 205-pressure monitoring components A 1, 206-pressure monitoring components A 2, 207-pressure monitoring part B, 208-pipeline control card A1, 209-pipeline control card A2, 210-pipeline control card B, 211-shaking table, 301-occlusion pump A flow velocity display screen, 302-occlusion pump B flow velocity display screen, 303-standardize solution infusion pump A flow rate set display screen, 304-standardize solution infusion pump B flow rate set display screen, 305-blood sampling total amount set and display screen, 306-dilutes total amount set and display screen, 307-alarm indicator is shielded, 308-pattern set and display shields, 309-numerical value adjusting knob, 310-trim button, 311-fast forward button, the main ACK button of 312-, 313-start stop button, 314-gas-monitoring components A, 315-gas-monitoring part B, 316-transfusion bag support, 317-screen ACK button.
Detailed description of the invention
Hereinafter with reference to accompanying drawing, embodiments of the invention are described in detail, only in order to the present invention is described, instead of in order to limit the scope of the invention.
Double-laparoscope central venous catheter and pipeline prepare
Select in the neck of patient, under clavicle or femoral vein inserts Double-laparoscope central venous catheter in puncture mode, for internal jugular vein cannulation (Fig. 1), blood is drawn or feedback by thicker tube chamber by the conduction hole (103) of side, diluent or liquid medicine injection are entered vein by thinner tube chamber by most advanced and sophisticated stomidium (102), with suture, fixed-wing (104) is fixed on patient skin, keeps catheter position.Supporting pipeline and monitoring, alarming accessory need be placed in main frame (Fig. 2) and control panel (Fig. 3) respectively.With pipe joint (109), the transducer potector branch (105) of Double-laparoscope central venous catheter is connected with liquid line (108) with transducer potector (107) respectively with liquid line branch (106).Transducer potector and liquid line and attached standardize solution transfusion branch line thereof, infusion connecting tube road, pressure monitoring device are all according in the main frame shown in the load map of mode shown in Fig. 42.Each pipeline far-end connects anticoagulant syringe (118), paramedicines syringe (119), blood storage bag (115), diluent bag (116) and transfusion bag (117) respectively.Pipeline trunk (106,107) embeds in the squeezing groove of occlusion pump, and (112,113,114 embed in associated pipe control card according to Fig. 4 its Main Branches.Will with gas in liquid emptying pipeline after pipeline installs.Hold the autologous blood collection of dilution, feedback Operation system setting is complete, for subsequent use.
The formation of control panel and setting
Control panel surface regulates button and display screen to form primarily of setting, and the surface placement of control panel as shown in Figure 3.Press the ACK button that display screen is other, display screen displaying contents glimmers, and related setting is in state of activation, at this moment can be undertaken setting and regulating by the button on control panel.Regulate button (309) by left rotation and right rotation numerical value, trim button (310) can regulating system operating parameters, after setting completed, press main ACK button (312) and complete setting.Press after starting stop button (313), each mechanical part of main frame will be started according to the duty arranged and pattern, again press running when starting stop button (313) and stop.After activating standardize solution transfusion display screen, press fast forward button (311) and ACK button (312) simultaneously, the quick liquid advanced in syringe of standardize solution infusion pump (303,304) can be started.Alarm indicator can display alarm type and position with (307), corresponding carry out adjustment after activate screen by the ACK button (317) on sub-screen side.Press main ACK button (312) again and can eliminate warning.After pattern set and display screen (308) activates screen by screen ACK button (317), button (309) is regulated by rotation numerical, can selective system mode of operation, press start stop button (313) mode of operation of setting can be started, again press and suspend existing mode of operation.
Blood conservation mode
The object of system works is autohemic drain, storage and feedback, and blood conservation is extremely important.The anticoagulant of filling line fully mixes with pipeline inner blood in occlusion pump (201) extrusion process, flow into the blood storage bag be placed on shaking table, after blood sampling starts, under shaking table is in the state of vacillating now to the left, now to the right all the time, until transfusion procedure terminates, by preventing thrombosis with upper type.Because erythrocyte can break in excessive lower pressure environment, cause haemolysis, pressure monitoring parts (205) are by the negative pressure state in main line in Real-Time Monitoring blood collection procedure, during safe condition lower than-10mmHg, trigger low-voltage is reported to the police, stop blood collection procedure, need readjust, arrange after restart blood sampling.
Standby host state
Pipeline connection, aerofluxus, duty and pattern are set after, can be in standby host state by initialization system, now, main frame 4 pumps all stop fortune dress, and 3 pipeline control cards are all closed, shaking table is static, and in pipeline, liquid all remains static.
Isovolumic hemodilution Autoblood collection duty
The packed cell volume diluted according to patient's Preoperative Method or hemoglobin concentration calculate predetermined blood sampling volume, at upper blood sampling total amount (305) and the occlusion pump A flow velocity (301) of regulating of control panel (Fig. 3) to predetermined value, regulate dilution total amount (306) and occlusion pump B flow velocity (302) to predetermined value, computer will set the flow velocity of standardize solution infusion pump A (203) automatically according to occlusion pump A (201) velocity of blood flow, press start stop button (313), Isovolumic hemodilution Autoblood collection system starts running (Fig. 5).
In transducer potector traveling, pipeline control card (208) opening, (209) are closed, occlusion pump A (201) is running counterclockwise, with active ways of negative pressure drainage by the side opening introduction pipeline of central vein blood from central venous catheter, anticoagulant is mixed in blood by standardize solution infusion pump A (203) in proportion, fully mix in occlusion pump A (201) extrusion process, entered to be placed in the blood storage bag (115) on shaking table (211) by the final drain of autologous blood of anticoagulant.Shaking table after blood collection procedure starts namely start wave antithrombotic, automatically stop until blood recovery process all terminates rear.
Pipeline control card (210) in liquid line traveling is open, and occlusion pump B (202) is running counterclockwise, and the stomidium by central vein pipe is injected patient's central vein by the diluent in diluent bag (116).
After reaching predetermined blood sampling volume, the autologous blood gatherer process of Isovolumic hemodilution stops, and system enters pipeline protection maintenance state (Fig. 6) running automatically.
Pipeline protection maintenance work state
Under pipeline protection maintenance state (Fig. 6); pipeline control card (208) is closed; pipeline control card (209,210) is open; occlusion pump (201) clockwise running, (202) operates counterclockwise; all with the flow velocity of 10ml/ hour, the liquid low speed in diluent bag and transfusion bag is pumped into central vein pipe and Deep venou; to avoid thrombosis in pipeline and central vein tube chamber, ensure the lasting unobstructed of system pass.Now, two standardize solution infusion pump (203,204) are in the state of shutting down.
Transfusion duty
When system uses as peri-operative central venous infusion control platform (Fig. 7), pipeline control card (208) is closed, pipeline control card (209,210) is open, two occlusion pumps (201,202) and two standardize solution infusion pump (203,204) can independent coutroi velocities, but in order to ensure the lasting unobstructed of pipeline, occlusion pump (201,202) setting flow velocity does not allow lower than 10ml/ hour.Occlusion pump (201,202) is generally used as conventional liq, and as the infusion of Glucose Liquid, normal saline or plasma substitute goods, flow is in the upper setting of control panel (301 or 302).Anticoagulant syringe (118) can be changed to paramedicines syringe (119), standardize solution infusion pump (203,204) is used as the liquid input that vasoactive drug, anesthetic and sedative drugs product etc. configure by normal concentration, flow can set at control panel (303,304), and by trim button (310) fine setting flow setting value, minimum flow adjustment unit can to 0.1ml/ hour, and fast forward button (311) can be passed through advance syringe fast, liquid will enter central vein fast.
Blood recovery duty
When needs of patients feeds back the autologous blood gathered, blood recovery pattern (Fig. 8) is selected by pattern setting interface (308) of control panel, liquid line maintains former operating condition in such a mode, in transducer potector, pipeline control card (208) is open, pipeline control card (209) is closed, occlusion pump A (201) startup operates clockwise, autologous blood in blood storage bag will be fed back to patient's central vein, and transfusion speed and total amount need by (301,305) settings on control panel.Blood recovery is after reaching predetermined value; pipeline control card (208) is closed; pipeline control card (209) is open, and occlusion pump A (201) reduces flow velocity to 10ml/ minute, and transducer potector enters pipeline protection maintenance work state automatically.
Safety monitoring warning system and termination of pumping state
In system operation process, walk in row line to arrange three place's pressure monitoring parts (205,206,207) (Fig. 2) at pipeline, implement monitoring pipeline inner pressure situation of change, hypertonia or too low exceed setting safety value after, to start sound and screen flicker warning, relevant infusion pump shuts down automatically.Arrange two place's gas controlling devices (314,315) (Fig. 3) on the control panel, if gas entrance, start sound and screen flicker warning, relevant infusion pump also will shut down automatically, avoids gas to input human body.Two standardize solution infusion pump inside arrange alarm for high voltage, can start sound and screen flicker warning.As shown in Figure 8, concrete alarm content will shield (307) upper display in control panel alarm indicator to safety monitoring warning system level.Once there is warning termination of pumping event, the necessary carefully check system of operator, removes risk factor, then restarting systems running.Under different mode, the termination of pumping state that different warning classification causes is different, is described below respectively.
Under Isovolumic hemodilution blood sampling mode state, no matter there is low pressure alarming in pressure monitoring parts (205), there is alarm for high voltage in (206 and or 207), or there is air inlet and report to the police in gas controlling device (314,315), except shaking table still keeps running external system by quit work (Figure 10) comprehensively, alarm content is in the upper concrete display of control panel (307).Now, pipeline control card (208,210) will transfer closedown to automatically from open, and in system, 4 infusion pump all shut down, and blood sampling and dilution operation stop.After hazard detection, eliminating, restart, system starts running preferentially giving tacit consent to former dilution blood sampling setting, also can reset rear running.
Report to the police under infusion mode state, 4 infusion pump do not associate each other, to cause the termination of pumping of relevant infusion pump according to concrete alarm content, the infusion pump be under normal condition works on, and alarm content is in the upper concrete display of control panel (307).Such as, infusion mode state downforce monitoring component B (207) occur alarm for high voltage and or gas-monitoring part B (315) occur air inlet report to the police, occlusion pump B (202) meeting termination of pumping, pipeline control card (210) will transfer closedown to automatically from open, (202) transfusion that pump is controlled will stop, and other infusion pump does not quit work (Figure 11).Two standardize solution infusion pump generation alarm for high voltage, relevant infusion pump will quit work, other infusion pump and pipeline control card duty unaffected.
Report to the police under blood transfusion mode state, as pressure monitoring components A 1 (205) occur alarm for high voltage and or gas-monitoring components A (314) occur air inlet report to the police, only occlusion pump A (201) meeting termination of pumping, pipeline control card (208) will transfer closedown to automatically from open, (201) blood transfusion that pump is controlled will stop, other infusion pump not stopping infusion work (Figure 12).
Computer control flow
Computer in main frame has the general framework in this area, comprises processor, memorizer, input part (knob, button) and efferent (display screen).The setting that computer control system accepts artificial input regulates information, through Computing, to the plant equipment on main frame, as pump, pipeline control card, shaking table, controls.After monitoring system sends warning message, relevant information will input computer automatically, and computer controls machinery automatically by according to the flow process set, until again start mechanical system running (Figure 13) after warning is eliminated in artificial adjustment again.Computer system controls automatically by software simulating, and those skilled in the art, according to systemic-function needs, use prior art, establishment predetermined software programs, and is stored in the memorizer of computer-internal in the device production phase, runs for after processor.Software can start operation automatically after input part is arranged, and also automatically can run after warning message input, control system and device enter safe condition.Pump, pipeline control card and shaking table are the final machinerys playing effect in control flow.
Central venous pressure is monitored
Due to pipeline and central vein UNICOM, the pressure monitoring parts (205,207) be in pipeline may be used for continuing or discontinuous measurement central venous pressure, and this is the important hemodynamic index in anesthesia management.
The foregoing is only exemplary embodiments of the present invention, can add based on enforcement of the present invention or delete corresponding handling process.For a person skilled in the art, the present invention can have various change and change.All any amendments, substitute equivalents, improvement etc. done based on exemplary embodiments of the present invention, all should be included within protection scope of the present invention.
In addition, those skilled in the art should be understood that, above-mentioned the present invention forms by comprising the pipe-line system of central vein catheter, dynamical system, monitor and alarm system, blood storage system and computer parametric controller 5 part, and involved material, device and mechanical system all can realize by general design.The input that computer parametric controller relates to, calculating and output can be realized by the executable program code of accountant, or are made into each integrated circuit modules respectively to realize.Like this, the present invention is not restricted to the combination of any specific hardware and software.
The foregoing is only the preferred embodiments of the present invention, be not limited to the system designed by the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (11)
1. the system of the autologous blood collection of Isovolumic hemodilution, feedback, automatically the dilution of blood, collection, anticoagulant and storage is completed under the control of the computer, feed back to patient when clinical needs, this system can also be used as peri-operative central venous infusion and central venous pressure monitoring, and this system comprises:
Computer parametric controller, parametric controller is by inputting setup control panel and computer is formed, and computer accepts the information of control panel and monitor and alarm system, by internal processor control system operating condition, and relevant information is shown, monitor adjustment for operator;
Dynamical system, associated pump device is arranged in pipeline traveling path, and promote pipeline and syringe inner blood, diluent or liquid medicine flow during pump running, operating condition controls platform courses by computer;
Monitor and alarm system, for ensureing whole system safe handling, with monitoring component to index Real-Time Monitoring in pipeline, once generation danger warning, computer parametric controller is by automatic motivation of adjustment working state of system, and primer liner control device, resistance stops liquid flow, ensures safety;
Blood storage system, the blood of collection adds anticoagulant, stores in blood storage bag;
Pipe-line system, it is the path of blood, diluent and medicine traveling, patient's vein, drug injector, transfusion bag and blood storage bag are coupled together, in pipeline, liquid flow is driven by dynamical system, state in pipeline is monitored by monitor and alarm system, and arranges the pipe controller that can hinder stopped pipe road.
2. system according to claim 1, is characterized in that, pipe-line system is made up of conduit, main line, branch line, connecting line, it is the path of blood, diluent or medicine traveling, autologous blood is preserved in blood storage bag, and is placed on shaking table, makes blood be in flow regime; Blood collection and diluent infusion rely on the conduit of inserting patient vessel, are drawn by blood or feed back, diluent is inputted blood vessel; Dynamical system is made up of pump installation, for blood drainage and blood transfusion and infusion provide power, also for injection anticoagulant and medicine provide power.
3. system according to claim 1, it is characterized in that, monitor and alarm system is made up of pressure monitoring parts, gas-monitoring parts and pipe controller, automatically the keying of associated pipe control device is adjusted by computer parametric controller, during resistance stopped pipe road, in pipeline, liquid flow stops, and reaches the object of monitoring, warning, security control.
4. system according to claim 1, is characterized in that, the pump installation in dynamical system can independently control one by one, for peri-operative central venous infusion; Pipeline is connected with central vein by central venous catheter, and the pressure monitoring parts in pipeline may be used for central venous pressure monitoring.
5. system according to claim 1, is characterized in that, computer parametric controller by inputting setup control panel and computer is formed, by control panel initialization system operating condition, and real-time display system operating condition, alarm condition; Computer accepts the information of input setup control panel and monitor and alarm system, is operated by computer-internal processor control system; The workflow of control system is: computer accepts the input information of input setup control panel and the monitoring information of monitor and alarm system, according to program prepared in advance, computing is carried out by computer, judge, output order, control the mechanical part in autologous blood collection, feedback system, i.e. the drive manner of pump installation, pipe controller, shaking table.
6. a device for the autologous blood collection of Isovolumic hemodilution, feedback, can be divided into main frame and control panel two large divisions, is made up of pump part, monitoring component, pipeline control card parts, control panel, shaking table;
Pump part is power resources, is made up of occlusion pump and standardize solution infusion pump;
Monitoring component monitors autologous blood collection, refluxing device running status, and operating condition extremely can trigger alarm;
Pipeline control card parts can open or close, and can the liquid in control piper pass through;
Control panel is made up of display unit, setting adjustment member and computer processor;
Shaking table tilts to wave makes the blood in blood storage bag be in flow regime.
7. device according to claim 6, it is characterized in that, device take electric power as the energy, pump part, pressure monitoring parts, pipeline control card parts are arranged on host platform surface, shaking table is arranged in the cabin of main frame inside, gas-monitoring parts are arranged on the control panel above main frame, and there are adjusting knob, button and display screen in control panel surface, and there is computer control panel inside.
8. device according to claim 6, is characterized in that, pump part is power resources, and the running of pump makes pipeline inner pressure change, for liquid drain or infusion provide power; The running of pump part is set by control panel, and computer instruction controls.
9. device according to claim 6, is characterized in that, pressure monitoring parts, gas-monitoring parts are in pipeline traveling path, and during trigger alarm, computer automatic command control system, makes pump part and pipeline control card parts make action.
10. device according to claim 6, it is characterized in that, control panel is made up of display unit, setting adjustment member and computer processor, and display unit can display device operation information and warning message, button is regulated by setting, can setting device mode of operation and parameter; Computer processor is according to the program prepared in advance operation according to flow control device.
11. devices according to claim 6, is characterized in that, shaking table provides power by the machinery of bottom, constantly tilt to wave, and make the blood in the blood storage bag of horizontal on it be in flow regime.
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| CN201210396281.8A CN103170024B (en) | 2012-10-18 | 2012-10-18 | Normovolemic dilution autoblood collection and reinfusion system, and normovolemic dilution autoblood collection and reinfusion device |
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| CN201210396281.8A CN103170024B (en) | 2012-10-18 | 2012-10-18 | Normovolemic dilution autoblood collection and reinfusion system, and normovolemic dilution autoblood collection and reinfusion device |
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| CN103170024B true CN103170024B (en) | 2015-06-03 |
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| CN108246188A (en) * | 2018-03-23 | 2018-07-06 | 吉林大学 | A kind of nutrient bag automatic mixing device |
| CN112999439A (en) * | 2018-09-28 | 2021-06-22 | 德州飚丰信息技术有限公司 | Clinical medical intelligent control drainage device |
| CN112618819B (en) * | 2021-01-07 | 2022-02-22 | 上海药明康德新药开发有限公司 | Novel automatic blood sampling instrument and blood sampling method design |
| CN113694294B (en) * | 2021-08-17 | 2024-02-13 | 南京多良喜科技有限公司 | Automatic pressure regulating type intraoperative autologous blood back transfusion device |
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