CN103157144A - Preparation method of anticoagulant coating on vascular stent - Google Patents
Preparation method of anticoagulant coating on vascular stent Download PDFInfo
- Publication number
- CN103157144A CN103157144A CN2011104196116A CN201110419611A CN103157144A CN 103157144 A CN103157144 A CN 103157144A CN 2011104196116 A CN2011104196116 A CN 2011104196116A CN 201110419611 A CN201110419611 A CN 201110419611A CN 103157144 A CN103157144 A CN 103157144A
- Authority
- CN
- China
- Prior art keywords
- preparation
- heparin
- anticoagulant
- vascular stent
- anticoagulant coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a preparation method of an anticoagulant coating on vascular stent, and belongs to the field of biomedical materials. The invention makes full use of the advantages of oxidized cellulose, and prepares a stable coating through compound of heparin and oxidized cellulose. The anticoagulant coating has high biocompatibility and long service life.
Description
Relate to the field
The present invention relates to the preparation method of anticoagulant coatings on a kind of intravascular stent, belong to biomedical materials field.
Technical background
The important method of the cardiovascular disease such as the vascular defects that nowadays, to insert endovascular stent be the treatment atherosclerosis, cause because of wound and disease and functional disorder.In most cases, support is by metal material, such as titanium alloy etc. is made.But, because of problems such as biocompatibility, make the generation that causes restenosis after Stent Implantation because of blood clotting.Therefore, the biological coating support that has an anticoagulant functions becomes the focus of present people's research.
Heparin is a kind of natural Coagulative inhibitors agent.Heparin is fixed in the biocompatibility that material surface can improve material effectively.But, general ionic bond and mode fixing heparin, though can keep heparin activity, heparin easily dissolves, exhausts from material surface, has affected the service life of material.
Oxidized cellulose is a kind of botanical material, and after controllable oxidization was processed, biocompatibility was very high, and can form very stable complex with heparin.This complex can stick to rack surface well.
Summary of the invention:
The object of the invention is to for passing through the fixing unsettled problem of heparin of ionic bonding mode.Take full advantage of the advantage of oxidized cellulose, by heparin and the compound stable coatings that obtains of oxidized cellulose, make the said anticoagulant coatings of the present invention.
The present invention is achieved in that
1 support is processed: the support of selecting is cleaned 10～30min with purified water, be placed in hydrogenperoxide steam generator, 60～80 ℃ are soaked 2～4h, and after taking out, purified water is rinsed well.
2 oxidized cellulose preparations: get Plant fiber and 10%～30%NAOH solution reaction, 1～2h, the centrifugal 5min of 7200r/min after taking out.Filter, add 1%～5% dilute hydrochloric acid and be neutralized to pH=7.
3 taking heparins mix with step 2 gained solution, 30 ℃ of cultivation 24h of constant-temperature table.
4 get step 1 gained support inserts in step 3 gained solution and soaks 2～4h, and deionized water rinsing is clean, lyophilizing, then insert in solution and soak, repeat 2 times, can obtain anticoagulant coatings of the present invention.
Wherein:
The described timbering material of step 1 refers to titanium alloy or stainless steel and other metal materials
The described Plant fiber of step 2 refers to that purity is the Cotton Gossypii more than 99%.
The described heparin of step 3 refers to the heparin of natural extract.
It is soluble that the anticoagulant coatings that the present invention obtains has overcome the heparin that is directly fixed on material surface, short-life weakness.Have powerful anticoagulant functions, and extended very longways the useful life.
Concrete enforcement:
1) support is processed: the support of selecting is cleaned 10min with purified water, be placed in hydrogenperoxide steam generator, 80 ℃ are soaked 4h, and after taking out, purified water is rinsed well.
2) oxidized cellulose preparation: get Plant fiber 5g and 15%NAOH solution 100ml reaction 2h, the centrifugal 5min of 7200r/min after taking out.Filter, add 1% dilute hydrochloric acid and be neutralized to pH=7.
3) taking heparin and step 2) gained solution mixes, and 30 ℃ of constant-temperature tables are cultivated 24h.
4) get step 1) the gained support inserts step 3) soaking 4h in gained solution, deionized water rinsing is clean, lyophilizing, then insert in solution and soak, repeat 2 times, can obtain anticoagulant coatings of the present invention.
Claims (1)
1. the preparation method of anticoagulant coatings on an intravascular stent is characterized in that anticoagulant coatings is by heparin and oxidized cellulose is compound to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104196116A CN103157144A (en) | 2011-12-15 | 2011-12-15 | Preparation method of anticoagulant coating on vascular stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104196116A CN103157144A (en) | 2011-12-15 | 2011-12-15 | Preparation method of anticoagulant coating on vascular stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103157144A true CN103157144A (en) | 2013-06-19 |
Family
ID=48581001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104196116A Pending CN103157144A (en) | 2011-12-15 | 2011-12-15 | Preparation method of anticoagulant coating on vascular stent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103157144A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519544A (en) * | 2017-08-28 | 2017-12-29 | 武汉杨森生物技术有限公司 | Compound anticoagulant heparin coating microballoon and preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0809999A2 (en) * | 1996-05-29 | 1997-12-03 | Ethicon, Inc. | Method of varying amounts of heparin coated on a medical device to control treatment thereon |
| CN101636187A (en) * | 2007-01-30 | 2010-01-27 | 汉莫堤克股份有限公司 | Biodegradable vascular support |
| CN101927037A (en) * | 2009-12-10 | 2010-12-29 | 西南交通大学 | Method for preparing anticoagulant vascular stent |
| WO2011059123A1 (en) * | 2009-11-11 | 2011-05-19 | 주식회사 메디프렉스 | Heparin compound bound to adhesive material, preparation method thereof, solid surface coating agent containing same as active ingredient, and coating method of solid surface using same |
-
2011
- 2011-12-15 CN CN2011104196116A patent/CN103157144A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0809999A2 (en) * | 1996-05-29 | 1997-12-03 | Ethicon, Inc. | Method of varying amounts of heparin coated on a medical device to control treatment thereon |
| CN101636187A (en) * | 2007-01-30 | 2010-01-27 | 汉莫堤克股份有限公司 | Biodegradable vascular support |
| WO2011059123A1 (en) * | 2009-11-11 | 2011-05-19 | 주식회사 메디프렉스 | Heparin compound bound to adhesive material, preparation method thereof, solid surface coating agent containing same as active ingredient, and coating method of solid surface using same |
| CN101927037A (en) * | 2009-12-10 | 2010-12-29 | 西南交通大学 | Method for preparing anticoagulant vascular stent |
Non-Patent Citations (3)
| Title |
|---|
| CLAUDIO SCHONAUER ETAL.: ""The use of local agents: bone wax,gelatin, collagen, oxidized cellulose"", 《EUROPEAN SPINE JOURNAL 》 * |
| 孙宾 等: ""医用可吸收氧化纤维素及其氧化体系研究进展"", 《中国纺织大学学报》 * |
| 许云辉 等: ""氧化纤维素的研究进展及发展趋势"", 《苏州大学学报（工科版）》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519544A (en) * | 2017-08-28 | 2017-12-29 | 武汉杨森生物技术有限公司 | Compound anticoagulant heparin coating microballoon and preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2013154612A3 (en) | Biodegradable vascular grafts | |
| US8415125B2 (en) | Method for preparing biological scaffold material | |
| CN102580153B (en) | Method for preparing allograft acellular dermal matrixes | |
| DK1343536T3 (en) | Process for decellularization of foreign material for bioprosthesis preparation | |
| CN102836464B (en) | Biological small-diameter artificial blood vessel and preparation method thereof | |
| JP6248051B2 (en) | Artificial blood vessel using decellularized blood vessel sheet | |
| CN101690829B (en) | Method for preparing re-cellularized biological valve material | |
| AU2742502A (en) | Tissue-engineered vascular structures | |
| CN103087834A (en) | Pre-cleaning and moisturizing composition of medical apparatuses and method of preparing disinfectant by using same | |
| CN102924613A (en) | Preparation method of dialdehyde bacterial cellulose | |
| CN110433341A (en) | A kind of tissue renovation material and preparation method thereof | |
| CN103656750A (en) | Method for improving various bionic functions on surface of cardiovascular implant material | |
| ATE480265T1 (en) | USE OF DENTAL FIBROBLAS TO TREAT VASCULAR CELLS | |
| CN103157144A (en) | Preparation method of anticoagulant coating on vascular stent | |
| CN102504327A (en) | Method for preparing cellulose sponge by utilizing sisal hemp wastes hemp bran and hemp head | |
| Mazloomnejad et al. | Angiogenesis and re-endothelialization in decellularized scaffolds: recent advances and current challenges in tissue engineering | |
| WO2005068007A3 (en) | Double-wire non-trapping angioplasty catheter | |
| CN109675112B (en) | Preparation method of human-derived acellular dermal matrix | |
| WO2012158470A3 (en) | Electrochemical formation of foil-shaped stent struts | |
| CN105131130A (en) | Synthetic method of oxidized cellulose | |
| CN102698323A (en) | Preparation method of anticlotting materials | |
| JP4964577B2 (en) | Modified lipophilic heparin, method for producing the same, and hair growth promoter | |
| RU2012104553A (en) | CELLS PRODUCED FROM CARDIAL FABRIC | |
| CN107137769A (en) | A kind of preparation method of the full organ acellular matrix of heart | |
| CN205041565U (en) | Vena cave thrombus extractor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130619 |