CN103156962A - Pharmaceutical combination of pure traditional Chinese medicines used for tonifying kidney and Qi, and resolving and relieving strangury, and preparation method thereof - Google Patents
Pharmaceutical combination of pure traditional Chinese medicines used for tonifying kidney and Qi, and resolving and relieving strangury, and preparation method thereof Download PDFInfo
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- CN103156962A CN103156962A CN 201110416018 CN201110416018A CN103156962A CN 103156962 A CN103156962 A CN 103156962A CN 201110416018 CN201110416018 CN 201110416018 CN 201110416018 A CN201110416018 A CN 201110416018A CN 103156962 A CN103156962 A CN 103156962A
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- 210000003734 kidney Anatomy 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 206010042170 Strangury Diseases 0.000 title abstract 3
- 229940126680 traditional chinese medicines Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 22
- 235000019640 taste Nutrition 0.000 claims abstract description 7
- 241000241550 Cyathula Species 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 241000545442 Radix Species 0.000 claims description 5
- 241000233948 Typha Species 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 230000000873 masking effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 230000027939 micturition Effects 0.000 abstract description 11
- 210000004369 blood Anatomy 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 8
- 201000007094 prostatitis Diseases 0.000 abstract description 6
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract description 5
- 239000002775 capsule Substances 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 208000013507 chronic prostatitis Diseases 0.000 abstract description 3
- 230000007812 deficiency Effects 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- 206010000060 Abdominal distension Diseases 0.000 abstract description 2
- 210000000952 spleen Anatomy 0.000 abstract description 2
- 210000003708 urethra Anatomy 0.000 abstract description 2
- 241000893536 Epimedium Species 0.000 abstract 1
- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 240000001398 Typha domingensis Species 0.000 abstract 1
- 230000003187 abdominal effect Effects 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 210000003932 urinary bladder Anatomy 0.000 description 11
- 238000011282 treatment Methods 0.000 description 6
- 230000002035 prolonged effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000004026 adhesive bonding Methods 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000012946 outsourcing Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 210000001113 umbilicus Anatomy 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010046555 Urinary retention Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 201000002327 urinary tract obstruction Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a pharmaceutical combination of pure traditional Chinese medicines used for tonifying kidney and qi, and resolving and relieving strangury, and a preparation method thereof. The pure herbal pharmaceutical combination comprises the following raw material drug ingredients, by weight: 40 parts of epimedium, 20 parts of astragalus root, 15 parts of cattail pollen, 20 parts of plantain, and 5 parts of cyathula root. A oral liquid of the invention is prepared based on compatibility principles of traditional Chinese medicine prescriptions, has the efficacies of tonifying kidney and qi, and resolving and relieving strangury, and can be used for diseases of deficiency of both kidney and spleen, blood stasis due to qi stagnation, prostatic hyperplasia, and chronic prostatitis; and symptoms of bright pale complexion, fatigue and lack of strength, abdominal falling distention, and ungratifying urination, difficult urination, or frequent urination, urgent urination, and painful urethra. Compared with existing pills, tablets and capsules with the same efficacy, the pharmaceutical combination of the present invention has advantages of small in dosage, good in taste, convenient for taking, fast in absorption, high in bioavailability, stable in quality, simple in preparation method, etc.
Description
Technical field
The invention belongs to the ethical goods technical field, particularly a kind of be used to tonifying Qi of the kidney, change treating stranguria pure Chinese medicine combination of pouring and preparation method thereof.
Background technology
Prostatosis comprises nonbacterial prostatitis, chronic prostatitis, prostatic hyperplasia, is frequently-occurring disease and the common disease of male senile patient.Its morbidity is disorderly with sex hormone metabolism, antibacterial infects, it is relevant to indulge in excessive drinking, often eat irritative food, constipation etc., suffers from cold and increases the weight of.According to clinical observation, patient has all that frequent micturition, urgent micturition, difficulty in micturition, lower limb distending pain, nocturia increase, impact is slept and come to go to a doctor.Chinese medicine there is no special topic and discusses, and essence, turbid, the difficulty in urination category of essence are leaked in subordination.Because it shows effect repeatedly, touching difficulty more, prolonged illness must the stasis of blood, prolonged illness must empty kidney qi virtual loss, functioning of bladder is unfavorable, the damp and hot part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of delaying, thereby deteriorated case comes out one after another therefore deficiency of kidney-QI, damp and hot knot, the blood stasis resistance is that pathogenesis is crucial.Prostate, bladder belong to the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels together, and exterior and interior relation between kidney and bladder is therefore prostatosis and kidney and bladder function imbalance are closely related.The lung being the upper source of fluids again, according to the theory of " upper orifices open lower orifices from logical ", the difficulty in urination of disturbance in water passage is associated with lung as can be known.From pathogenic analysis, kidney qi is feeble and exhausted, the not all right water of gas, and water retention accumulates and heat-transformation, and heat is disturbed smart chamber, and the astringency inducing dereliction of duty is compeled smart absurd row and is leaked essence; Damp-heat gluing each other, clear QI being mixed up with turbid QI sees that essence is turbid.Kidney unit virtual loss, decline of the fire from the gate of life, gasification is not as good as bladder, and bladder transmits unable, or the smart decocting liquid of pathogenic heat consumption, and kidney yin is lost greatly, gasify passive, and prolonged illness must be empty, and prolonged illness must the stasis of blood, blood stasis due to qi deficiency, the stasis blocking water channel, functioning of bladder is unfavorable, and folding is neglected one's duty, and is the difficulty in urination.Damp-heat gluing each other, frying in shallow oil Tianjin is expectorant.Primary disease is dialectical with kidney asthenia as the principal aspect, and the expectorant stasis of blood is damp and hot is mark, when driving away pathological factor, protects admittedly Kidney-Yinly, makes gas living to some extent.So gas be sun, positive depletion of YIN and changing without institute, " be apt to YANG invigorating person, treating YANG within YIN is apt to nourishing YIN person, treating YIN within YANG ", regulating YIN and YANG makes equilibrium between yin and yang, functioning of bladder functional rehabilitation and sick spontaneous recovery.According to theory of Chinese medical science, the clinical damp-heat in the urinary bladder that is divided into, stagnation of QI due to depression of the liver, sinking of QI of middle-JIAO, kidney qi such as do not fill at all polymorphic types.The oral solid formulation such as the ball of the existing treatment in market relevant disease, sheet, capsule but the difficulty of taking medicine reaches the effective blood drug concentration time long carries inconvenience.
Summary of the invention
Purpose of the present invention aims to provide a kind of be used to tonifying Qi of the kidney, and changes treating stranguria pure Chinese medicine combination of pouring and preparation method thereof, and it has tonifies Qi of the kidney, and changes the treating stranguria effect of pouring.Be used for the kidney spleen two empty, qi depression to blood stasis, prostatic hyperplasia, chronic prostatitis; The complexion rolling is white, the tired power of body, and sagging distention in the smaller abdomen, urine is not well, and drop does not go out, frequent micturition, urgent micturition, Urethra astringent pain.Its taking dose is little, mouthfeel good, taking convenience, absorption is very fast, bioavailability is high, steady quality, production technology are simple.
Technical scheme of the present invention is: design a kind of be used to tonifying Qi of the kidney, change treating stranguria pure Chinese medicine combination of pouring and preparation method thereof, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 40 parts of Herba Epimedii, 20 parts of the Radixs Astragali, 15 parts of Pollen Typhaes, 20 parts of Herba Plantaginiss, 5 parts of Radix Cyathulaes.
Described a kind of be used to tonifying Qi of the kidney, it comprises the following steps the preparation method of the pure Chinese medicine combination that the change pouring is treating stranguria:
1) by following weight ratio weighting raw materials: 40 parts of Herba Epimedii, 20 parts of the Radixs Astragali, 15 parts of Pollen Typhaes, 20 parts of Herba Plantaginiss, 5 parts of Radix Cyathulaes;
2) the above five tastes, decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, gradation filtered, and merging filtrate adds ethanol and makes and contain the alcohol amount and reach 70%, standing 4～6 hours, reclaims ethanol;
3) add 1.5% active carbon, heated 30 minutes, filter;
4) add 0.5% stevioside, taste masking;
5) adding distil water to total amount, filters, packing, and sterilization gets final product.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment
A kind of be used to tonifying Qi of the kidney, it adopts following steps to make to change treating stranguria pure Chinese medicine combination of pouring and preparation method thereof:
1) by following weight ratio weighting raw materials: 40 parts of Herba Epimedii, 20 parts of the Radixs Astragali, 15 parts of Pollen Typhaes, 20 parts of Herba Plantaginiss, 5 parts of Radix Cyathulaes;
2) the above five tastes, decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, gradation filtered, and merging filtrate adds ethanol and makes and contain the alcohol amount and reach 70%, standing 4～6 hours, reclaims ethanol;
3) add 1.5% active carbon, heated 30 minutes, filter;
4) add 0.5% stevioside, taste masking;
5) adding distil water to total amount, filters, packing, and sterilization gets final product.
The below is that the embodiment of the present invention is a kind of be used to tonifying Qi of the kidney, and changes treating stranguria pure Chinese medicine (hereinafter to be referred as embodiment of the present invention medicine) the clinical treatment case of pouring
the inventor divides two groups to carry out respectively embodiment of the present invention medicine and outsourcing prostatitis capsule oral to 58 routine benign prostate hyperplasias, 2 courses for the treatment of are totally 8 weeks, carrying out curative effect after drug withdrawal 4 weeks sums up, result shows that two groups of patient's lower urinary tract obstruction symptoms obviously alleviate, the symptom knot divides, residual urine, Qmax and AFR etc., than all being greatly improved before medication, embodiment of the present invention medicine oral liquid group total effective rate is 89.2%, outsourcing prostatitis Capsules group total effective rate is 86.2%, before and after two groups of treatments, the prostatic function scoring relatively has significant difference (P＜0.05), comparison zero difference between group (P〉0.05).Clinical use in 1 year shows, the present invention has no side effect, and is the comparatively ideal clinical treatment medicine for the treatment of hyperplasia of prostate.The advantages such as Chinese medicine combination of the present invention has that taking dose is little, mouthfeel good, taking convenience, absorption is very fast, bioavailability is high, steady quality, production technology are simple.Conventional equipment can be completed production, is worth further research.
Claims (2)
1. one kind is used for tonifying Qi of the kidney, and changes treating stranguria pure Chinese medicine combination of pouring and preparation method thereof, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 40 parts of Herba Epimedii, 20 parts of the Radixs Astragali, 15 parts of Pollen Typhaes, 20 parts of Herba Plantaginiss, 5 parts of Radix Cyathulaes.
2. above-mentioned a kind of be used to tonifying Qi of the kidney, it comprises the following steps the preparation method of the pure Chinese medicine combination that the change pouring is treating stranguria:
1) by following weight ratio weighting raw materials: 40 parts of Herba Epimedii, 20 parts of the Radixs Astragali, 15 parts of Pollen Typhaes, 20 parts of Herba Plantaginiss, 5 parts of Radix Cyathulaes;
2) the above five tastes, decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, gradation filtered, and merging filtrate adds ethanol and makes and contain the alcohol amount and reach 70%, standing 4～6 hours, reclaims ethanol;
3) add 1.5% active carbon, heated 30 minutes, filter;
4) add 0.5% stevioside, taste masking;
5) adding distil water to total amount, filters, packing, and sterilization gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110416018 CN103156962A (en) | 2011-12-14 | 2011-12-14 | Pharmaceutical combination of pure traditional Chinese medicines used for tonifying kidney and Qi, and resolving and relieving strangury, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110416018 CN103156962A (en) | 2011-12-14 | 2011-12-14 | Pharmaceutical combination of pure traditional Chinese medicines used for tonifying kidney and Qi, and resolving and relieving strangury, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103156962A true CN103156962A (en) | 2013-06-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110416018 Pending CN103156962A (en) | 2011-12-14 | 2011-12-14 | Pharmaceutical combination of pure traditional Chinese medicines used for tonifying kidney and Qi, and resolving and relieving strangury, and preparation method thereof |
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| CN (1) | CN103156962A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656435A (en) * | 2013-12-19 | 2014-03-26 | 青岛中科菲力工程技术研发有限公司 | Traditional Chinese medicine capsule for treating prostatitis and preparation method of capsule |
-
2011
- 2011-12-14 CN CN 201110416018 patent/CN103156962A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656435A (en) * | 2013-12-19 | 2014-03-26 | 青岛中科菲力工程技术研发有限公司 | Traditional Chinese medicine capsule for treating prostatitis and preparation method of capsule |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C05 | Deemed withdrawal (patent law before 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130619 |