CN103145868B - A kind of lower molecular weight osamine polysaccharid derivative and pharmaceutical composition thereof and its preparation method and application - Google Patents
A kind of lower molecular weight osamine polysaccharid derivative and pharmaceutical composition thereof and its preparation method and application Download PDFInfo
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- CN103145868B CN103145868B CN201310099800.9A CN201310099800A CN103145868B CN 103145868 B CN103145868 B CN 103145868B CN 201310099800 A CN201310099800 A CN 201310099800A CN 103145868 B CN103145868 B CN 103145868B
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- China
- Prior art keywords
- molecular weight
- low molecular
- dlfg
- weight glycosaminoglycan
- pharmaceutically acceptable
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- 238000000034 method Methods 0.000 claims description 64
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 41
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 39
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 36
- -1 alkaline earth metal salt Chemical class 0.000 claims description 29
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- SHZGCJCMOBCMKK-UHFFFAOYSA-N 6-methyloxane-2,3,4,5-tetrol Chemical compound CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 24
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 24
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 claims description 19
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- 229910052717 sulfur Inorganic materials 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940073455 tetraethylammonium hydroxide Drugs 0.000 description 1
- LRGJRHZIDJQFCL-UHFFFAOYSA-M tetraethylazanium;hydroxide Chemical compound [OH-].CC[N+](CC)(CC)CC LRGJRHZIDJQFCL-UHFFFAOYSA-M 0.000 description 1
- LPSKDVINWQNWFE-UHFFFAOYSA-M tetrapropylazanium;hydroxide Chemical compound [OH-].CCC[N+](CCC)(CCC)CCC LPSKDVINWQNWFE-UHFFFAOYSA-M 0.000 description 1
- 229960003766 thrombin (human) Drugs 0.000 description 1
- 238000001551 total correlation spectroscopy Methods 0.000 description 1
- 229910001428 transition metal ion Inorganic materials 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Name of raw and auxiliary materials | Dosage of |
dLFG-IE | 50g |
Water for injection | l000mL |
Are co-produced into | 1000 pieces |
Name of raw and auxiliary materials | Dosage of |
dLFG-2A | 50g |
Water for injection | 500mL |
Are co-produced into | 1000 pieces |
Claims (16)
Priority Applications (6)
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CN201310099800.9A CN103145868B (en) | 2013-01-07 | 2013-03-26 | A kind of lower molecular weight osamine polysaccharid derivative and pharmaceutical composition thereof and its preparation method and application |
JP2016504458A JP6293862B2 (en) | 2013-03-26 | 2013-12-20 | Low molecular weight glycosaminoglycan derivative and drug composition thereof, production method and use thereof |
PCT/CN2013/090131 WO2014153995A1 (en) | 2013-03-26 | 2013-12-20 | Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof |
US14/778,966 US9896517B2 (en) | 2013-03-26 | 2013-12-20 | Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof |
EP13880342.4A EP2980103B1 (en) | 2013-03-26 | 2013-12-20 | Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof |
CA2907887A CA2907887C (en) | 2013-03-26 | 2013-12-20 | Low-molecular-weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof |
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CN201310003518 | 2013-01-07 | ||
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CN201310099800.9A CN103145868B (en) | 2013-01-07 | 2013-03-26 | A kind of lower molecular weight osamine polysaccharid derivative and pharmaceutical composition thereof and its preparation method and application |
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CN103145868B true CN103145868B (en) | 2015-09-16 |
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EP2980103B1 (en) * | 2013-03-26 | 2020-11-04 | Jiuzhitang Co., Ltd. | Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof |
CN103788222B (en) * | 2014-01-08 | 2016-08-31 | 中国科学院昆明植物研究所 | Substituted oligomeric glycosaminoglycans of Fuc3S4S and preparation method thereof |
CN104558223B (en) * | 2014-09-17 | 2016-10-05 | 中国海洋大学 | A kind of high-purity Apostichopus japonicus glycosaminoglycans and its preparation method and application |
CN104370980B (en) * | 2014-10-17 | 2017-12-01 | 九芝堂股份有限公司 | A kind of oligosaccharide compound and its pharmaceutical composition for suppressing endogenous factors X enzymatic activitys |
CN106349407A (en) * | 2016-08-29 | 2017-01-25 | 中国海洋大学 | Low-molecular-weight fucosylated chondroitin sulfate, preparation method thereof and application of low-molecular-weight fucosylated chondroitin sulfate to preparation of medicine for resisting Trousseau syndrome |
CN108285498B (en) * | 2017-01-10 | 2021-11-23 | 九芝堂股份有限公司 | Oligosaccharide compound for inhibiting endogenous coagulation factor X enzyme complex and preparation method and application thereof |
CN110776578B (en) * | 2019-11-12 | 2021-01-29 | 苏州颐华生物医药技术股份有限公司 | Low-molecular sea cucumber glycosaminoglycan and application thereof |
WO2021128253A1 (en) * | 2019-12-27 | 2021-07-01 | 深圳市海普瑞药业集团股份有限公司 | Glycosaminoglycan derivative and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102050888A (en) * | 2010-12-13 | 2011-05-11 | 河北常山生化药业股份有限公司 | Method for preparing enoxaparin sodium |
CN102329397A (en) * | 2011-10-19 | 2012-01-25 | 中国科学院昆明植物研究所 | Fucosylated glycosaminoglycan derivative and preparation method thereof |
CN102558392A (en) * | 2010-12-14 | 2012-07-11 | 王芃 | Preparation method of high-FXa-resistant low-FIIa-resistant low-molecular heparin sodium |
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FR2663639B1 (en) * | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | LOW MOLECULAR WEIGHT POLYSACCHARIDE BLENDS PROCESS FOR PREPARATION AND USE. |
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CN102050888A (en) * | 2010-12-13 | 2011-05-11 | 河北常山生化药业股份有限公司 | Method for preparing enoxaparin sodium |
CN102558392A (en) * | 2010-12-14 | 2012-07-11 | 王芃 | Preparation method of high-FXa-resistant low-FIIa-resistant low-molecular heparin sodium |
CN102329397A (en) * | 2011-10-19 | 2012-01-25 | 中国科学院昆明植物研究所 | Fucosylated glycosaminoglycan derivative and preparation method thereof |
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Inventor after: Zhao Jinhua Inventor after: Liu Jikai Inventor after: Wu Mingyi Inventor after: Gao Na Inventor after: Lu Feng Inventor after: Li Zi Inventor after: Li Zhenguo Inventor after: Chen Yanming Inventor before: Zhao Jinhua Inventor before: Liu Jikai Inventor before: Wu Mingyi Inventor before: Gao Na Inventor before: Lu Feng Inventor before: Li Zi |
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Effective date of registration: 20160519 Address after: 410205 Changsha high tech Zone, Tongzi, west slope road, No. 339, No. Patentee after: JIUZHITANG Co.,Ltd. Address before: 650201 Yunnan Province, Kunming City Blue Black Road No. 132 Patentee before: Kunming Institute of Botany, Chinese Academy of Sciences |
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Effective date of registration: 20170718 Address after: 410205 Changsha high tech Zone, Tongzi, west slope road, No. 339, No. Co-patentee after: Friends of Mudanjiang Bo Pharmaceutical Co.,Ltd. Patentee after: JIUZHITANG Co.,Ltd. Co-patentee after: HAINAN JIUZHITANG PHARMACEUTICAL CO.,LTD. Address before: 410205 Changsha high tech Zone, Tongzi, west slope road, No. 339, No. Patentee before: JIUZHITANG Co.,Ltd. |
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Correction item: Patentee|Address|Patentee Correct: Jiuzhitang Co., Ltd.|410205 No. 339 west slope, Tongzi hi tech Development Zone, Hunan, Changsha|Mudanjiang Youbo Pharmaceutical Co.,Ltd.|Hainan Jiuzhitang Pharmacy Co., Ltd. False: Jiuzhitang Co., Ltd.|410205 No. 339 west slope, Tongzi hi tech Development Zone, Hunan, Changsha|Friends of Mudanjiang Bo Pharmaceutical Co., Ltd.|Hainan Jiuzhitang Pharmacy Co., Ltd. Number: 31-02 Volume: 33 |