CN103142896A

CN103142896A - Medicine for treating osteonecrosis of femoral head

Info

Publication number: CN103142896A
Application number: CN2013101070721A
Authority: CN
Inventors: 刘新宇; 张守潘; 刘芳; 朱民
Original assignee: 刘新宇
Priority date: 2013-03-29
Filing date: 2013-03-29
Publication date: 2013-06-12
Anticipated expiration: 2033-03-29
Also published as: CN103142896B

Abstract

The invention provides a medicine for treating osteonecrosis of the femoral head. The medicine for treating the osteonecrosis of the femoral head comprises the following medicinal materials by weight: 30g of stir-baked squama manitis, 60g of garter snake, 30g of leech, 30g of scorpio, 30g of centipede, 20g of eupolyphaga, 60g of roasted tortoise plastron, 30g of deer-horn glue, 30g of dragon's blood, 20g of vinegar rhizoma corydalis, 40g of asarum, 6g of hedyotis diffusa, 50g of radix achyranthis bidentatae, 30g of pseudo-ginseng, 50g of gastrodia elata, 40g of rhizoma drynariae, 30g of bark of eucommia, 30g of himalayan teasel root, 30g of loranthus parasiticus, 30g of morinda officinalis, 30g of cistanche salsa, 30g of rhizoma cibotii, 20g of common curculigo rhizome, 20g of pyrola, 20g of frankincense, 30g of myrrh, 40g of safflower, 20g of Chinese angelica, 30g of astragalus mongholicus, 50g of prepared rehmannia root, 30g of berba aristolochiae mollissimae, 30g of cortex illicii, 30g of obscured homalomenarhizome, 30g of garden balsam stem, 30g of shinyleaf pricklyash root, 50g of liquorice, 20g of hawthorn and 30g of barley malt. The medicine for treating osteonecrosis of the femoral head has an exact curative effect through clinical verification.

Description

A kind of medicine for the treatment of femur head necrosis

Technical field

The present invention relates to a kind of medicine for the treatment of femur head necrosis, be specifically related to a kind of medicine of the treatment femur head necrosis that is prepared from by Chinese herbal medicine.

Background technology

Femur head necrosis is obstructed because of its main Department of Pathology femoral head blood fortune, wrecks and the head sclerotin ischemia that causes, therefore be called ischemic necrosis of femoral head or aseptic necrosis of femoral head, is one of common osteoarthritis more.Mostly because the illness such as rheumatism, hematopathy, bends, burn cause, first destroy the blood supply of adjacent joints covering weave, and then cause necrosis.Its cardinal symptom develops into rest pain gradually from discontinuity pain, then by pain cause muscle spasm, joint motion is restricted, cause at last seriously to disable and walk lamely.Hormone drug also can cause the generation of primary disease.The traditional Chinese medical science thinks that the disease occurrence cause is exopathogenic factor and endogenous cause of ill, and the endogenous cause of ill exopathogenic factor interacts, and makes the yin-Yang disequilibrium, and the mistake of QI and blood is permanent and give birth to disease, also claims " thigh pivot numbness ", " rheumatism involving the bone ", " bone withers ".Its desirable treatment is the stage in early days, especially before x-ray is found, if adopt an effective measure rapidly, can prevent collapse of the femoral head, the Saving cortilage function.The medicine for the treatment of femur head necrosis is a lot of at present, certain therapeutic effect is also arranged, but therapeutic effect significantly seldom.

Summary of the invention

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of hyperosteogeny, it is through clinical verification, determined curative effect.

the present invention is prepared from by the crude drug of following weight: stir-baked SQUAMA MANITIS 30g, Zaocys 60g, Hirudo 30g, Scorpio 30g, Scolopendra 30g, eupolyphaga 20g, Carapax Et Plastrum Testudinis (processed) 60g, Colla cornus cervi 30g, Sanguis Draxonis 30g, stir-baked RHIZOMA CORYDALIS with vinegar 20g, Herba Asari 40g, Herba Hedyotidis Diffusae 6g, Radix Achyranthis Bidentatae 50g, Radix Notoginseng 30g, Rhizoma Gastrodiae 50g, Rhizoma Drynariae 40g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Herba Taxilli 30g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Rhizoma Cibotii 30g, Rhizoma Curculiginis 20g, Herba Pyrolae 20g, Olibanum 20g, Myrrha 30g, Flos Carthami 40g, Radix Angelicae Sinensis 20g, Radix Astragali 30g, Radix Rehmanniae Preparata 50g, Herba Aristolochiae Mollissimae 30g, Cortex schizophragmatis integrifolii radicis 30g, Rhizoma Homalomenae 30g, Herba speranskiae tuberculatae 30g, Radix Zanthoxyli 30g, Radix Glycyrrhizae 50g, Fructus Crataegi 20g, Fructus Hordei Germinatus 30g.

Preparation method: get above each flavor, mixing is pulverized, and adds suitable quantity of water, general one-tenth piller, and drying, and get final product.

Instructions of taking: an above prescription is a course for the treatment of, and take 2-3 every day, each 5-10 gram, taking medicine after meal.

The present invention can also adopt the modern pharmaceutical technology to adopt the methods such as water extraction, alcohol extraction, diafiltration, supercritical extraction of other preparation methoies such as routine to extract effective ingredient in medicine, and can add pharmaceutically the adjuvant that allows to be prepared into other dosage form, as powder, big honeyed pills, tablet, granule, capsule, drop pill, slow controlled-release target preparation etc.

The present invention is applicable to the diseases such as femur head necrosis, mandatory spondylitis, hemiplegia, intractable lumbago and skelalgia, sciatica, intervertebral disk hernia, spinal canal stenosis, amyotrophy.

Clinical data

The case source

Choose case 100 examples that are diagnosed as femur head necrosis, get rid of relative similar disease, and merge the heart, cerebrovascular disease, the abnormal person of hepatic and renal function, male 55 examples wherein, female's 45 examples; Age 22-71 is between year, average 57.4 years old; The elder of the course of disease 6 years, the shortest person 3 months, I phases 29 hip wherein, II phases 33 hip, III phases 35 hip, IV phases 75 hip, totally 172 hips.By stages with reference to international bone circulation science can appointment standard: i.e. 0 phase: x line sheet, MR I, E C T are all normal, could find osteonecrosis when only the tissue in taking out femoral head carries out cut sections for microscopic examination; The I phase: X-ray film is normal, and MRI, ECT image can note abnormalities; The II phase: x line sheet, MRI, E C T all can note abnormalities, but the femoral head profile is normal; The III phase: x line sheet shows that femoral head has slightly and subsides; The IV phase: X-ray film shows that collapse of the femoral head flattens; The V phase: X-ray film shows that hip joint space narrows down.

Therapeutic Method

Adopt the medicine of the embodiment of the present invention 1 preparation, a prescription was 1 course for the treatment of, and take 2-3 every day, each 5-10 gram, taking medicine after meal.Treat observe the curative effect after 3 courses for the treatment of, avoid during treatment bearing a heavy burden, the alleviating alcohol addiction smoking cessation.

Criterion of therapeutical effect

Cure: hip joint is without pain, and lower limb are without cripetura, and function is recovered fully, and imaging examination is normal.

Take a turn for the better: the hip arthralgia obviously alleviates, and the hip joint movable function is good, and lower limb shorten less than l c m, and iconography femur head necrosis phenomenon is improved.

Invalid: the hip arthralgia is without obvious alleviation, and lower limb shorten greater than l c m, and X-ray film, C T check that femoral head becomes large or flat, and the osteonecrosis phenomenon is unchanged.

Therapeutic outcome

Therapeutic outcome such as following table:

Can be found out by above data, the present invention reaches 84.9% to the femur head necrosis total effective rate; Wherein I phase effective percentage is that 100% II total effective rate is 94.%; III phase total effective rate is 93.8%; IV phase total effective rate is 71.8%.This shows, medicine of the present invention has significant curative effect to femur head necrosis.

The specific embodiment

The present invention is further illustrated below in conjunction with embodiment.

Embodiment 1

take stir-baked SQUAMA MANITIS 30g, Zaocys 60g, Hirudo 30g, Scorpio 30g, Scolopendra 30g, eupolyphaga 20g, Carapax Et Plastrum Testudinis (processed) 60g, Colla cornus cervi 30g, Sanguis Draxonis 30g, stir-baked RHIZOMA CORYDALIS with vinegar 20g, Herba Asari 40g, Herba Hedyotidis Diffusae 6g, Radix Achyranthis Bidentatae 50g, Radix Notoginseng 30g, Rhizoma Gastrodiae 50g, Rhizoma Drynariae 40g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Herba Taxilli 30g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Rhizoma Cibotii 30g, Rhizoma Curculiginis 20g, Herba Pyrolae 20g, Olibanum 20g, Myrrha 30g, Flos Carthami 40g, Radix Angelicae Sinensis 20g, Radix Astragali 30g, Radix Rehmanniae Preparata 50g, Herba Aristolochiae Mollissimae 30g, Cortex schizophragmatis integrifolii radicis 30g, Rhizoma Homalomenae 30g, Herba speranskiae tuberculatae 30g, Radix Zanthoxyli 30g, Radix Glycyrrhizae 50g, Fructus Crataegi 20g, Fructus Hordei Germinatus 30g, mixing, pulverize, add suitable quantity of water, general one-tenth piller, dry.

Claims

1. medicine for the treatment of femur head necrosis, medical material by following weight is prepared from: stir-baked SQUAMA MANITIS 30g, Zaocys 60g, Hirudo 30g, Scorpio 30g, Scolopendra 30g, eupolyphaga 20g, Carapax Et Plastrum Testudinis (processed) 60g, Colla cornus cervi 30g, Sanguis Draxonis 30g, stir-baked RHIZOMA CORYDALIS with vinegar 20g, Herba Asari 40g, Herba Hedyotidis Diffusae 6g, Radix Achyranthis Bidentatae 50g, Radix Notoginseng 30g, Rhizoma Gastrodiae 50g, Rhizoma Drynariae 40g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Herba Taxilli 30g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Rhizoma Cibotii 30g, Rhizoma Curculiginis 20g, Herba Pyrolae 20g, Olibanum 20g, Myrrha 30g, Flos Carthami 40g, Radix Angelicae Sinensis 20g, Radix Astragali 30g, Radix Rehmanniae Preparata 50g, Herba Aristolochiae Mollissimae 30g, Cortex schizophragmatis integrifolii radicis 30g, Rhizoma Homalomenae 30g, Herba speranskiae tuberculatae 30g, Radix Zanthoxyli 30g, Radix Glycyrrhizae 50g, Fructus Crataegi 20g, Fructus Hordei Germinatus 30g.