CN103130304A - Method for removing spiramycin in water in nanofiltration mode - Google Patents
Method for removing spiramycin in water in nanofiltration mode Download PDFInfo
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- CN103130304A CN103130304A CN2011103851331A CN201110385133A CN103130304A CN 103130304 A CN103130304 A CN 103130304A CN 2011103851331 A CN2011103851331 A CN 2011103851331A CN 201110385133 A CN201110385133 A CN 201110385133A CN 103130304 A CN103130304 A CN 103130304A
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- spiramycin
- nanofiltration
- water
- spiramycin base
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Abstract
The invention relates to a method for removing spiramycin in water in a nanofiltration mode. By means of the characteristic that the nanofiltration membrane separation technique can be used for effectively removing 200-1000 organics, the method for removing the spiramycin in water in a nanofiltration mode can well retain spiramycin with more than 800 molecular weight in water. According to the method for removing the spiramycin in water in a nanofiltration mode, spiramycin solutions with different concentrations are treated as research objects, different nanofiltration membranes are selected, the operating pressure and the operation temperature are changed, a nanofiltration separation performance test is carried out, and the research on the removal of the spiramycin is investigated. The method for removing the spiramycin in water in a nanofiltration mode provides a feasible control technology for effectively removing the spiramycin in water, and has wide application prospects.
Description
Technical field
The present invention relates to a kind of nanofiltration and remove the method for Spiramycin Base in water, belong to water-treatment technology field.
Background technology
Spiramycin Base (spiramycin) is macrolide antibiotics, and its structure has opticity and ultraviolet characteristic absorbance.Be biological (comprising animal, plant and microorganism) produce or obtain by additive method in its vital movement process, can suppress selectively or affect the organic substance that it plants biological function under humble concentration.Its molecular weight is 843.06, be mainly used in clinically at present infecting due to gram positive organism, part gram-negative bacteria, rickettsia, large C-type virus C etc., in China's annual production over 2000 tons.Because present Spiramycin Base is not controlled as water-quality guideline, therefore special disposal link for Spiramycin Base is seldom arranged in water treatment procedure, this has also caused the high residue of Spiramycin Base in processing waste water, the pollution and the consequent environmental effect that have caused Spiramycin Base to be discharged in water body, water body being caused are more and more serious, serious threat is to the mankind's health, and existing removal method (as: Physical, chemical method, physico-chemical processes etc.), under many circumstances, be difficult to remove Spiramycin Base in water.Therefore, in the urgent need to effectively remove the Spiramycin Base in water by employing new technology.
Nanofiltration (Nanofiltration) is a kind of novel pressure drive membrane sepn process that development in recent years is got up, and it is between reverse osmosis and ultrafiltration.In quite a few refractory organic industrial sewage, the component that needs Separation and Recovery is molecular weight less than 2000 low molecule organic matter, as dyestuff intermediate in the microbiotic in pharmaceutical industry, VITAMIN, pharmaceutical intermediate, DYE PRODUCTION process etc., between 200～1000, nanofiltration membrane is held back the optimum range of particle diameter to its molecular weight just mostly.This characteristics determined nanofiltration be with a wide range of applications in refractory organic industrial sewage is processed.
The present invention proposes a kind of method of utilizing nanofiltration to process Spiramycin Base in water, for the removal of Spiramycin Base in water provides a kind of feasible treatment process.
Summary of the invention
Purpose of the present invention is exactly to utilize the separation characteristic of nanofiltration membrane self, and a kind of nanofiltration method that can effectively remove Spiramycin Base in water is provided.
Main technical content of the present invention is: the Spiramycin Base solution of preparation different concns, select different nanofiltration membrane, and change working pressure and temperature, carry out the nanofiltration separation performance test, investigate the removal research to Spiramycin Base.
Spiramycin Base concentration range of the present invention is 50～150mg.L
-1
Nanofiltration membrane of the present invention is NF270, any one of NF200 or NF90.
Working pressure scope of the present invention is 0.4MPa～1.2MPa.
Embodiment
Remove the method for Spiramycin Base in water below in conjunction with a kind of nanofiltration of the present invention, the specific embodiment of the present invention is described.
Embodiment 1
Preparation 50mgL
-1The Spiramycin Base stock liquid, keeping feed temperature is 25 ℃, selects the NF90 nanofiltration membrane, adjustment operation pressure is 0.6MPa, carries out the nanofiltration separation performance test, is 94.8% to the rejection of Spiramycin Base.
Embodiment 2
Preparation 50mgL
-1The Spiramycin Base stock liquid, keeping feed temperature is 35 ℃, selects the NF90 nanofiltration membrane, adjustment operation pressure is 0.6MPa, carries out the nanofiltration separation performance test, is 95.6% to the rejection of Spiramycin Base.
Embodiment 3
Preparation 100mgL
-1 Spiramycin Base stock liquid, keeping feed temperature is 25 ℃, selects the NF90 nanofiltration membrane, adjustment operation pressure is 1.0MPa, carries out the nanofiltration separation performance test, is 97.2% to the rejection of Spiramycin Base.
Embodiment 4
Preparation 50mgL
-1The Spiramycin Base stock liquid, keeping feed temperature is 25 ℃, selects the NF90 nanofiltration membrane, adjustment operation pressure is 1.0MPa, carries out the nanofiltration separation performance test, is 94.0% to the rejection of Spiramycin Base.
Claims (5)
1. the method for Spiramycin Base in water is removed in a nanofiltration, it is characterized in that: the Spiramycin Base solution of preparation different concns, selects different nanofiltration membrane, and change service temperature, working pressure, carry out the nanofiltration separation performance test, investigate the removal of Spiramycin Base is studied.
2. Spiramycin Base according to claim 1, it is characterized in that: its main component contains SPM I, II, III, and concentration range is 50～150mgL
-1
3. nanofiltration membrane according to claim 1, it is characterized in that: nanofiltration membrane is NF270, any one in NF200 or NF90.
4. service temperature according to claim 1, it is characterized in that: scope is 25～45 ℃.
5. working pressure according to claim 1, it is characterized in that: scope is 0.4MPa～1.2MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103851331A CN103130304A (en) | 2011-11-28 | 2011-11-28 | Method for removing spiramycin in water in nanofiltration mode |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103851331A CN103130304A (en) | 2011-11-28 | 2011-11-28 | Method for removing spiramycin in water in nanofiltration mode |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103130304A true CN103130304A (en) | 2013-06-05 |
Family
ID=48490823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103851331A Pending CN103130304A (en) | 2011-11-28 | 2011-11-28 | Method for removing spiramycin in water in nanofiltration mode |
Country Status (1)
| Country | Link |
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| CN (1) | CN103130304A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107266512A (en) * | 2017-08-09 | 2017-10-20 | 福建和泉生物科技有限公司 | A kind of purification process of spiramvcin |
| CN107840864A (en) * | 2017-10-31 | 2018-03-27 | 无锡福祈制药有限公司 | A kind of purification process of spiramvcin |
-
2011
- 2011-11-28 CN CN2011103851331A patent/CN103130304A/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| EVA STEINLE-DARLING等: "Nanofiltration for traceorganic contaminant removal:structure,solution,and membrane fouling effects on the rejection of perfluorochemicals", 《ENVIRON.SCI.TECHNOL.》 * |
| 宋力航，孔瑛等: "聚酰亚胺纳滤膜分离螺旋霉素萃取液", 《化学工业与工程》 * |
| 李鑫玮，祝万鹏等: "酚类分子结构和纳滤膜特性对截留率的影响规律", 《环境化学》 * |
| 蔡邦肖: "纳滤膜技术在螺旋霉素生产中应用初探", 《膜科学与技术》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107266512A (en) * | 2017-08-09 | 2017-10-20 | 福建和泉生物科技有限公司 | A kind of purification process of spiramvcin |
| CN107840864A (en) * | 2017-10-31 | 2018-03-27 | 无锡福祈制药有限公司 | A kind of purification process of spiramvcin |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130605 |