CN103115898B - The reading equipment of result of laboratory test in a kind of test carrier - Google Patents
The reading equipment of result of laboratory test in a kind of test carrier Download PDFInfo
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- CN103115898B CN103115898B CN201110365514.3A CN201110365514A CN103115898B CN 103115898 B CN103115898 B CN 103115898B CN 201110365514 A CN201110365514 A CN 201110365514A CN 103115898 B CN103115898 B CN 103115898B
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Abstract
The present invention provides a kind of reading equipment of result of laboratory test in test carrier, including test carrier；At least one light-emitting component, send light and be irradiated in test carrier in corresponding one or more areas；At least one photodetector, for detecting the light sent from one or more areas in the test carrier and at least one conducting light paths structure, the light that the conducting light paths structure allows light-emitting component to send can be irradiated in test carrier, while allows in one or more areas in test carrier the light sent to be received by photodetector.The reading equipment of the present invention includes enabling the conducting light paths structure that light preferably turns on, the accuracy and precision that can detect the equipment further increases, meanwhile, take off-loadable form, the equipment is carried out multiple detection, increase utilization rate of equipment and installations and be easier to operate to operator.
Description
Technical field
Theme disclosed by the invention is related to the reading equipment for being assayed object measured value.Especially, it is related to electronical reading
Device, it is used together with using the chemical examination test piece of measuring method.
Background technology
A variety of families that are suitable to can be bought in the market uses the analytical equipment tested assay.Unipath
A kind of suitable measurement pregnancy hormone Human chorionic is just sold under CLEARBLUE trade (brand) names（hCG）Crossing current immunoassays
Equipment, the equipment is disclosed in EP291194.
Specifically, EP291194 discloses a kind of immunoassay device, including：The test carrier of one porous, should
Carrier includes the particular combination reagent marked for a kind of particulate of assay, and under dampness, the reagent can be moved freely
It is dynamic；With a kind of particular combination reagent of the not tape label for same assay, the reagent is fixed on the spy of the not tape label
In detection zone or the test section of determining adhesive agent downstream.Suspect that the liquid sample containing the assay is applied to described porous ooze
The carrier of water, acted in the particular combination reagent of the assay thereon and particulate mark, form a kind of assay-combination
Complex.The particulate mark is coloured, is typically gold or dyeing condensate, for example, latex or poly- sub- peace fat.It is described multiple
Zoarium is subsequently moved within detection zone, compound in the particular combination reagent of detection zone and the not tape label of fixation composition is another
Body so that the existence range of the assay is detected or observed.
By electronic readout and test carrier, such as analytical test strip, combine to detect in fluid sample and analyze
The concentration and/or amount of thing are known technologies, such as Chinese patent 200410045273.4；200410045275.3；
200410063910.0 as described.In general, the light irradiation test-strips sent from light source such as light emitting diode, and use up
Detector detects reflected light or transmitted light.Typically, the reader at least contains a light emitting diode, and each is sent out
Optical diode is designed with corresponding photodetector.
Device disclosed above and specific product are implemented to open, and in these equipment, test-strips all and read equipment all
Assembled in advance to be fixed together, test-strips and the position read between equipment are producing, and transport, sale and test, and survey
Try there is no any change between them all in a relatively-stationary state after terminating.Such structure is mainly transported at present
Use in early pregnancy detection, user is only needed urine leaching in the water absorbent sheet of test device, just can directly be waited to be tested
As a result.As consumer is to the continuous demand of this kind of product, it is desirable to such detection is applied in all other detection, this
Just need to provide some different reading equipment to meet growing market needs.Such as：An equipment is needed to enter
The detection of the multiple samples of row, or, test result is more accurate etc..
The content of the invention
In order to solve the problems, such as some of the above, the equipment that the present invention provides test result on a kind of read test carrier, it is wrapped
At least one light-emitting component is included, light is sent and is irradiated in test carrier in corresponding one or more areas；At least one light inspection
Device is surveyed, for detecting the light sent from one or more areas in the test carrier;With at least one conducting light paths knot
Structure, the light that the conducting light paths structure allows light-emitting component to send can be irradiated in test carrier, while one allowed in test carrier
The light sent in individual or multiple areas can be received by photodetector.
Conducting light paths structure enable to test carrier some or some regions and light-emitting component and photodetector one
In the space of individual relative closure, the light outside this space cannot be introduced into the space；And the light in the space also only
It can be transmitted in the space, the light in the space can be made more fully to be utilized effectively, and make certain of test carrier
One or some regions can optimize（It is the maximum amount of）The light for receiving light-emitting component, as far as possible reduce light be irradiated to other areas
Domain；Also, sent from test carrier（Reflection）Light fully can also be received by photodetector；Meanwhile the conducting light paths knot
Structure can sufficiently avoid mirror-reflection.The light that i.e. the conducting light paths structure can send light-emitting component has certain light path to lead to
Road, and the light for receiving photodetector has certain scope；Namely the light that can send light-emitting component is blocked in necessarily
Region in, such as, on the test zone of test carrier；And so that photodetector can be received only in test carrier
The light sent.
In one embodiment, test carrier is coordinated in the form of off-loadable with the equipment." off-loadable " herein can be with
It is that when not detected also, can allow and test carrier and read equipment and separate, when detection is needed, allow survey
Examination carrier is combined with reading equipment, with reference to time can be that test carrier is applied in before sample or afterwards, allow reading equipment reading
Take the test result in test carrier., can also be from reading or the form of " off-loadable " is also possible that after the completion of detection
Test carrier is isolated in equipment, carries out the reading for test result in next test carrier of identical sample or different samples
Take.So allow read equipment can be more cost-effective and be advantageous to environment guarantor with the result on continuous several times read test carrier
Shield.Even, material different in the off-loadable equipment detection sample can be used.
In preferred embodiment, at least one conducting light paths structure is made up of at least two parts, at least two parts
Between in the form of off-loadable coordinate.In one embodiment, a part of conducting light paths structure bit at least in two parts
In in equipment, another part conducting light paths structure at least in two parts is located in test carrier.It is another in preferred embodiment
Part conducting light paths structure is located in the detection zone of test carrier.Optionally, another part conducting light paths structure is also located at surveying
On the detection control area or/and reference area for trying carrier.
When test carrier is combined with the equipment in the form of off-loadable, the conducting light paths structure can be divided at least two
Point, a portion is located in equipment, encloses and closes light-emitting component and photodetector, and another part conducting light paths structure bit
In in some or some regions or whole test carrier of test carrier, for enclosing all or part of area in test carrier
Domain.Two parts of conducting light paths structure are also to be coordinated in the form of off-loadable, and being formed when this two parts is combined together can be close
The space of test carrier, light-emitting component and photodetector is closed, the space can stop that the light in the external world enters the blocking element
In space, and the light that can send the light-emitting component in the space is merely able to transmit in the space, and according to certain
Path channels transmission；I.e. so that the luminous energy that light-emitting component is sent reaches certain part area of test carrier according to certain passage
Domain, and the light of the subregion is reached photodetector by certain passage.
In another preferred embodiment, test carrier is in a housing, another part at least in two parts
Conducting light paths structure is located on the housing.Preferably, housing includes window corresponding with test carrier subregion, it is described extremely
Another part conducting light paths structure in few two parts is located on the window.
When test carrier coordinates with equipment for off-loadable formula, its advantage is available with equipment and tested in multiple test carriers
Sample, be more convenient operation.But also to consider some problems：Wish that previous test-strips not made to later test-strips first
Into any pollution, it is further desirable that avoiding some mechanical parts in equipment to cause to test carrier structure during insertion
Infringement；And the chemical reagent of some to being anticipated by accurate processing on carrier causes damage or loss of function, because
The invalid or inaccurate of test result can be caused for these destructions.At the same time, it is desirable to the cooperation position phase of carrier and reading equipment
To fixation, and it is accurate to cooperate, and is so only possible to not influence the result finally read, the result so read is more accurate
Really, when while repeatedly test same sample using different test carriers, the result of acquisition is more consistent, and misses
Difference is controlled in tolerance interval.Increase a housing in test carrier, it is possible to avoid these above-mentioned problems.When with
When the test carrier of housing patches with detection device, originally directly it was in contact and was changed in test carrier with equipment by test carrier
Housing directly contacted with equipment.Housing directly contacts with detection device, does not influence the test carrier positioned at enclosure interior, together
When, it also avoid the sample of test carrier can touch detection device, not interfere with the detection of next test carrier.Therefore,
Increase a housing in test carrier, be very important in the off-loadable equipment, not only make the service life of equipment
Increase, the accuracy and accuracy of detection can also be increased.Further, the conducting light paths knot being originally located in test carrier
Another part of structure is changed on the housing.Conducting light paths structure on the housing and the conducting light paths knot in equipment
Structure coordinates for off-loadable formula, when in the test carrier insertion equipment with housing, two-part conducting light paths respective outer side edges will be surveyed
Some or some regions or whole test carrier for trying carrier are enclosed in conducting light paths structure, make it not by ambient
Irradiation, and the light for making it internal can only be transmitted internally, increase the utilization of light.
In one embodiment, window exposes test zone and the control area of test carrier on housing；Preferably, shell
Window also exposes the reference area of test carrier on body.
In another embodiment, at least one light-emitting component includes three light-emitting components, and at least one photodetector includes
Three photodetectors, at least one path channels structure include three conducting light paths structures.
In preferred embodiment, three light-emitting components, three photodetectors and three conducting light paths elements are one a pair
It should be related to, i.e. a light-emitting component, a photodetector and a conducting light paths structure form a conducting light paths system.And
And each conducting light paths system corresponds to the test zone of test carrier, or reference area, or control area.It is more specifically real
Apply in mode, the first light-emitting component corresponds to the test zone of test carrier, and corresponding with the first photodetector, positioned at the first light path
In conducting structure；And second light-emitting component correspond to the reference area of test carrier, it is and corresponding with the second photodetector, be located at
In second conducting light paths structure；And the 3rd light-emitting component correspond to the control area of test carrier, and with the 3rd photodetector pair
Should, in the 3rd conducting light paths structure.
Specifically, the light-emitting component sensitivity for improving detection corresponding with a photodetector.Some tradition
The device using optical detection generally using a photodetector correspondingly test more than one need detect light structure, than
Such as, a photodetector detects the light that multiple regions are sent, or, a photodetector detection is sent by multiple light-emitting components
Light.So, the data cross between regional and/or interference can be present, so as to occur detection reaction it is slow or
As a result inaccurate situation, or even have the inaccurate situation of testing result.In the present invention, three corresponds, there is provided special
Element carry out corresponding detection, can improve sensitivity and the accuracy of detection.
In another preferred embodiment, three photodetectors are respectively in the both sides of light-emitting component.Photodetector is respectively in
Light-emitting component both sides, can make to maintain a certain distance between each photodetector, and can guarantee that each photodetector with
Light-emitting component is closest, avoids photodetector and receives the light of other light-emitting component and produce interference, influences to detect reading
Accuracy and accuracy.Specifically, the first, the second, the three light-emitting component arranges along straight line, and first and the 3rd examines
The side that device is located at light-emitting component is surveyed, the second detector is located at the opposite side of light-emitting component.
More specifically in embodiment, another light-blocking member is included between one-to-one light-emitting component and photodetector,
Another light-blocking member separates one-to-one light-emitting component and photodetector.Another blocking element can stop luminous member
The light of part shines directly into photodetector, avoids the influence to the data on photodetector read test carrier.
In some preferable specific embodiments, in each conducting light paths system, the conducting light paths structure in equipment
The face of neighbouring photodetector is domatic；Conducting light paths structure on housing is vertical plane adjacent to the face of photodetector.The neighbour
Conducting light paths structure on the housing of optical detectors by it is common it is domatic be changed to vertical plane, can avoid what light-emitting component was sent
The domatic rear mirror-reflection formed for the conducting light paths structure that light is shone directly on original housing；Light irradiation simultaneously
After on vertical plane till now, by reflection, light reaches the region that the needs in test carrier irradiate, so as to add the light
The amount of light and intensity that light in the conducting structure of road is reflexed in test carrier, it can further improve and be surveyed in test carrier
Try the result display effect in region.
In other preferred embodiments, in each conducting light paths system, the conducting light paths structure of neighbouring light-emitting component
Two parts not on same vertical plane, part on housing than in equipment partially away from light-emitting component.When luminous
After element emits beam, have some light and be transmitted on each face of the conducting light paths structure, and reflected.It is neighbouring luminous
The face of element can also receive light and be reflected, and most of light reflected can be shone directly on photodetector,
And the conducting light paths structure on housing is formed further from after light-emitting component in test carrier and equipment between light path conducting structure
One groove, after the light that light-emitting component is sent reaches groove, it can be reflexed to through recess sidewall in test carrier, so, both
Reduce the light not being irradiated in test carrier directly to reflex on photodetector, while increase light incides test carrier again
On.
In one embodiment, the equipment also includes blocking element, and the blocking element can stop that external light source enters
Enter in the equipment；And being formed can stop external light source into test zone and/or reference area and/or detection in test carrier
The structure of control area.
When test carrier is located in equipment, the blocking element can prevent some that light is irradiated in test carrier or
Some regions or whole test carrier, further, also light can be prevented to be irradiated to the photodetector being similarly positioned in equipment
And light-emitting component.For some or some regions or the whole test carrier that ensure that ambient is not irradiated in test carrier,
The blocking element surrounds some or some regions of test carrier or whole test carrier so that extraneous light cannot be introduced into
Some on to test carrier or some regions or whole test carrier；Also, the blocking element also surrounds light-emitting component and light
Detector so that ambient can not also be irradiated to both elements.On the other hand, the blocking element by test carrier some
Or some regions or whole test carrier and light-emitting component and photodetector encirclement, additionally it is possible to the light quilt for sending light-emitting component
It is blocked in certain region, it is preferred that on the test zone of test carrier；And so that photodetector can be received only
The light sent on to test carrier.For more specifically, the blocking element causes some or some regions and hair of test carrier
In the space of a relative closure, the light outside this space cannot be introduced into the space for optical element and photodetector；And
And the light in the space can only also transmit in the space.
In preferable mode, the blocking element of part forms conducting light paths structure.Blocking element is by some of test carrier
Or a certain region, such as：Test zone, and/or reference area, and/or control area, and light-emitting component and photodetector enclose
In the space of a closing, it is set not disturbed by ambient, meanwhile, it also ensure that the abundant of internal illumination element light
Utilize.Wherein, the space of the closing is divided into one or more conducting light paths structures by the part of blocking element.
Beneficial effect
The reading equipment of the present invention includes enabling the conducting light paths structure that light preferably turns on, and can make what the equipment detected
Accuracy and precision further increases, meanwhile, off-loadable form is taken, the equipment is carried out multiple detection, is increased
Utilization rate of equipment and installations is simultaneously easier to operate to operator.
Brief description of the drawings
Fig. 1 is that equipment optical texture is read in an embodiment（Conducting light paths structure）Cross-sectional view；
Fig. 2 is the optical texture that equipment is read in another embodiment of the invention（Conducting light paths structure）Cross-section structure shows
It is intended to；
Fig. 3 is the optical texture that equipment is read in presently preferred embodiment（Conducting light paths structure）Section knot
Structure schematic diagram；
Fig. 4 is that the configuration schematic diagram of equipment is read in one embodiment of the present invention and includes test carrier
The dimensional structure diagram of housing；
Fig. 5 is the overlooking the structure diagram of housing in one embodiment of the present invention；
Fig. 6 is the present invention looks up structural representation of the reading equipment comprising blocking element of one embodiment of the present invention；
Fig. 7 is to read equipment in the specific embodiment of the present invention with stereochemical structure during shell combination to show
It is intended to（Do not include test carrier and the lower part of housing）（Seen from above）；
Fig. 8 is to read equipment in the specific embodiment of the present invention with another stereochemical structure during shell combination to show
It is intended to（Do not include test carrier and the lower part of housing）（See from below）；
Fig. 9 be the specific embodiment of the present invention in read equipment with present invention looks up structural representation during shell combination
（Do not include test carrier and the lower part of housing）；
Figure 10 is the part structure for amplifying schematic top plan view for the reading equipment for including blocking element；
Figure 11 is the vertical section structure schematic diagram of the A-A` in Fig. 7（Do not include test carrier and the lower part of housing）；
Figure 12 is the cross-sectional view of the B-B` in Fig. 7；
Figure 13 is LED and PD detectors and test zone in test carrier in the specific embodiment of the present invention；
Locus projection relation schematic diagram between reference area and testing result control area；
Figure 14 is a light road schematic diagram in conducting light paths structure of the invention；
Figure 15 is another light road schematic diagram in conducting light paths structure of the invention.
Description of reference numerals
Read the optical texture of equipment（Conducting light paths structure）100；The optical texture of another reading equipment of the present invention（Light
Road conducting structure）200,201；The present invention includes the reading equipment 400 of blocking element；Reading comprising test carrier and housing is set
Standby 300；Light-emitting component 105；Photoelectric detector 103；LED 51,52,53；PD detectors 41,42,43；Conducting light paths knot
Structure（A part for blocking element） 101；Light path conducting structure in equipment（Blocking element in equipment）202；Conducting light paths on housing
Structure（Blocking element on housing）203；Domatic the 106 of conducting light paths structure；Light path conducting structure domatic 2021 in equipment；Housing
Upper light path conducting structure vertical plane 2031；The another side of light path conducting structure in equipment（Nearly light-emitting component）2022；Housing glazing
The another side of road conducting structure（Nearly light-emitting component）2032；Test carrier 10；The film 120 of test carrier；Pcb board 102；Separately
One light-blocking member 104,44,45；Housing 30 containing test carrier；Shell window 90,35,36,37；Housing groove 34；On housing
31 at sample addition；Top shell component 71；Bottom shell component 72；It is affectedly bashful position 73；Housing side grooves 32；Window is directed on housing
Mouth 33；Blocking element 40 in equipment；Blocking element 38,39,61,62 on housing；Blocking element card article 406,407 in equipment；If
The alignment windows 47 of standby upper blocking element；Blocking element window 401,402,403 corresponding with shell window in equipment；In equipment
Blocking element projection 404 corresponding with housing groove 34；Blocking element is raised in equipment（For laying light-emitting component and light detection
Device）70；It is spaced the projection 701,702,703,704 of light-emitting component；The projection 705 of interval photodetector, 706,707,708,
709；The test zone 130 of test carrier, reference area 140, control area 150；Blocking element recess 48；Indicated on housing
74；Path channels structure 80；Part blocking element 75,76 on housing 30；Groove area 85 in conducting light paths structure.
Embodiment
In an embodiment of the invention, read equipment and include test carrier 10, at least one light-emitting component 105,
At least one photodetector 103 and blocking element 101.
Test carrier 10 can select the test strip of lateral flow, such as US6156271, US5504013, EP728309
Or the form disclosed in EP782707, it can detect a variety of analytes.Certainly, other suitable test carriers can also be used
In the present invention.Multiple regions can be included in the test carrier 10, such as, for adding the sample area of sample, display detection
As a result test section 130, control zone 150 etc..Test section 130 is the region that optical signal is formed in test carrier（Such as graininess
The accumulation area or storage area of the label of coloured binding reagents）, indicate whether test analyte be present（Explain in passing,
When not having test analyte, some analyses such as substitution analysis may form signal）.Control zone 150 is formed in test carrier
The region of optical signal, for show test it is correct carry out and/or binding reagents are effective, and with the presence or absence of test analyte
It is unrelated.Under normal circumstances, reference area 140 is the region for only forming " background " signal, such as the signal is available for calibration analysis
As a result reading plotter and/or the background signal referred to is provided for test signal.
In one embodiment, test carrier includes sample area, test section 130, control zone 150 and suction zones.Another reality
Apply in mode, the test carrier includes sample area, test section 130, reference region 140, control zone 150 and suction zones.Preferably, survey
Try on the subregion on carrier 10, film 120 can be added to prevent unnecessary sample from being oozed out from the region of test carrier.
Light-emitting component 105 is used to emit beam, such as various light sources.In one embodiment, the light-emitting component is
LED.Light-emitting component 105 is one or more, such as, for 1, or 2, or 3,4 and the above etc..
Photodetector 103 is used for detecting the light that is irradiated to thereon, and in a specific embodiment, the photodetector is light
Electric diode（PD detectors）.The quantity of photodetector 103 is also one or more, such as 1, or 2, or 3,4 and
More than etc..
In the present invention, conducting light paths structure is at least one, and in specific embodiment, the conducting light paths structure is 1, or 2
It is individual or 3.
In the reading equipment of the present invention, blocking element 101 is that an integral member is formed, or multiple component combinations
Form.The blocking element 101 can make light-emitting component 105 in the reading equipment 100 and photodetector 103 and positioned at reading
The subregion of test carrier 10 in equipment is not by the irradiation and interference of ambient.
In the reading equipment 100, light-emitting component 105 and photodetector 103 can position in the inner, test carrier 10 also may be used
With positioned at read equipment in, and blocking element 101 then can be located at the equipment 100 inside or outside, as long as can meet stop outside
Boundary's light enters the function of device interior.
The making material of the reading equipment 300 is extensive, such as the material such as PP, PVC or plastics, an embodiment
In, the reading device is made up of lighttight plastic material.The material of blocking element needs to meet the function being in the light, and other are not
Limit.The material can with to read equipment identical or different, in a preferable concrete mode, the material that blocking element uses is not yet
Lighttight plastic material is identical with reading equipment material.
In one specific embodiment, after sample is added in test carrier after a period of time（This refers to for a period of time
Analyte and the detection material that can be reacted with analyte in sample disposed in advance in test carrier are anti-in sample
Between seasonable, generally, this is 5-10 minutes for a period of time）, light-emitting component is emitted beam, be irradiated to a certain in test carrier or
Light is reflected in some regions, the region for receiving light, and reflected light is irradiated on photodetector.Then, detected by light
Device read light come show the sample in these regions reaction result.
The reading equipment of the present invention, as shown in figure 1, it includes at least one light-emitting component 105, sends light and irradiates
On to the film 120 of test carrier 10 or test carrier；At least one photoelectric detector 103, carried for detecting from the test
The light sent in one or more areas on body 10, and blocking element 101, test carrier 10 is allowed by the blocking element 101
It is fixed together with light-emitting component 105 and photodetector 103, while rational layout, it can smoothly complete to test carrier 10
On test result be read out.Preferably, light-emitting component 105 and photoelectric detector 103 are located on pcb board 102.This reading
Equipment 100 is that test carrier 10 and equipment 100 are fixed together, and after completing to test, reads equipment 100 and test carrier 10 is lost
Abandon, as disposable equipment.Such equipment causes the waste of resource and is unfavorable for environmental protection, such in addition to set
It is standby to carry out the repeatedly reading to different test carriers.
The reading equipment 200 of another embodiment of the invention, can be used for multiple times reading equipment, it is cost-effective simultaneously
Reduce and waste.The reading equipment 200 of the optimization is unlike previous embodiment, and test carrier 10 is with reading equipment 200 simultaneously
It is not integrally fixed at together, the two is combined for off-loadable formula.Here " off-loadable " can be understood as：First separate,
Then contact with each other to form the part of a completion；It can be appreciated that：Complete two of some function set up separating or
In the case of incorrect position, two components can not realize after two components combination can into the function of component, only when
Two components, which are combined, could realize certain function.For specific, the equipment 200 includes at least one light-emitting component
105, send light and be irradiated on the film 120 of test carrier 10 or test carrier in corresponding one or more areas；At least one
Individual photodetector 103, for detecting the light sent from one or more areas in the test carrier 10;And blocking element
101, the blocking element 101 can stop that the light in the external world enters in equipment, even if ambient can not be irradiated to the light inspection in equipment
Survey device 103, light-emitting component 105, test carrier 10；Wherein, test carrier 10 is off-loadable form group with reading equipment 200
Close.In order to coordinate test carrier, blocking element 101 can be that at least two parts form, wherein one with reading the detachable of equipment
In equipment 202, another part is located in test carrier 203 for part, and the two also coordinates for off-loadable form, as shown in Fig. 2
When equipment 200 is read without test result on read test carrier 10, a part 202 for blocking element and the member that is in the light
Another part 203 of part is separated without contacting；When needing to be read out test result, test carrier 10 is allowed to be inserted into reading
In taking equipment 200, and a part 202 for blocking element contacts with another part 203 of blocking element and forms one completely
Blocking element 101, now read equipment 200 complete test carrier 10 on test result reading.For example, in fig. 2, it is in the light
A part 202 for element with another part 203 of blocking element when separating, due in the absence of test carrier or test carry
The malposition of body（Relative to light-emitting component 105, the position of photoelectric detector 103）, it is impossible to it is correct to carry out in test carrier
The reading of test result, conversely, the reading of test result can be carried out correctly.Certainly, a part 202 for blocking element can be with
On the pcb board 102 read in equipment, and with light-emitting component 105, detector 103 together as another separate part,
Numbering is that C is present；Another part 203 of blocking element can be single together as a part, numbering D with test carrier 10
Solely exist.When needing to carry out test result in test carrier 10, two different portions of include blocking element two are allowed
After part C and D are coupled to suitable position, the reading of whole test result is completed.Certainly, a part 202 for blocking element and gear
Another part 203 of optical element may be located on reading in other parts and/or the structure of equipment, when not carrying out test load also
On body when the reading of test result, both parts are separated, when need in test carrier test result read when
Wait, allow two previously separated parts to be coordinated, allow test carrier to be in suitable position with light-emitting component and tester,
Carry out the reading of test result.
Fig. 4-13 is the overall reading equipment 300 in the preferred embodiment of the present invention.
As shown in figure 4, test carrier 10, in a housing 30, housing 30 includes upper and lower two housing parts 71,
72, they are engaged by the form of buckle or rivet, and test carrier 10 is between upper and lower two housing parts 71,72 and is consolidated
It is scheduled in housing 30.So, when the test carrier 10 with housing is patched with reading equipment, sample contact can be avoided
To equipment is read, test carrier can also be avoided to be damaged.It is provided with top shell component 71 and exposes test carrier upper part
The window 90 in region.Can be test zone 130 by the region in test carrier 10 that window 90 exposes, the He of reference area 140
It is one or several in control area 150.The shape of window 90 can be according to needing exposed shape to be appointed on test zone
Meaning designs, usually rectangle, naturally it is also possible to for circular or ellipse.Window 90 can directly be exposed in test carrier
Area or by transparent piece（Film）120 coverings, but do not influence to be mapped to survey from the illumination that light-emitting component 105 is sent
Try on carrier 10, the light nor affected on carrier 10 is received through the piece or film 120 by photoelectric detector 103.Shell
Also include alignment windows 33 on body 30, the window 33 is used to be aligned with a certain correspondence position in equipment, to ensure that housing insertion is set
The correct position specified whether is reached in standby..Adding mouth 31 is also devised with housing 30, the adding mouth 31 and test carrier 10
Communicate, when needing detection, sample is added from there and reached in test carrier 10.Adding mouth is meeting the function of sample-adding
It is required that its lower profile is unlimited, in a specific embodiment, in order that the housing 30 preferably coordinates with equipment 400, the adding mouth
31 are designed as circular protrusions, i.e., outside to be cylindrical, and the internal structure for former taper.In addition, it can also be set on housing 30
In respect of facilitating what operator's hand took to be affectedly bashful position 73, when operator, which pinches this, is affectedly bashful position 73, can accurately be carried out with equipment
Insert or pull out.In order to allow the operator to will accurately be examined in the housing insertion equipment with test carrier
Survey, be designed with the arrow 74 for indicating operator's plug orientation in one end of remote the sample tap 31 of housing 30, such as " ", " " or
" → " etc..
In a specific embodiment, another part 203 of blocking element is located on housing 30 and carried with exposure test
The correspondence of window 90 of body, such as on the window in top shell component 71.A part 203 for blocking element is by window
Different designs can mark off window 90 different parts, such as window is divided into three by two tiny glazing bar 38,39
Individual wicket 35,36,37, such division by the region that window 90 exposes in test carrier just being also just divided into three areas
Domain, for example, test zone 130, reference area 140 and testing and control region 150, as shown in Figure 4 and 5 and 13.On unit D
Blocking element 203 can be located on housing 30, and the blocking element 203 on the housing 30 consolidates the subregion in test carrier 10
Determine and surround.Specifically, 61 and the 62 of the outer side shield of the small parting bead 38,39 on window and window collectively form housing 30
On blocking element 203.After the housing 30 with test carrier 10 inserts equipment 400, the blocking element 203 of the part is with setting
Standby upper blocking element 202 coordinates, and forms the space of a closing so that the subregion in test carrier 10, light-emitting component
105 and photodetector 103 be located in the closing space.
In another specific embodiment, blocking element 202 forms another independent with light-emitting component 105 and photodetector 103
Part C is located in equipment 400, as shown in figure 4, the part 40 of blocking element that should be in equipment（202）For an entirety,
There is a projection 70 on the blocking element part, there are multiple spaces separated in projection 70, for installing light-emitting component 105
With photodetector 103, and light-emitting component 105 and photodetector 103 are separated.More specifically in embodiment, such as Figure 10 and
Shown in Figure 11, projection 701,702,703 and 704 is separated out the space for laying light-emitting component 105, for laying 3 light-emitting components,
That is LED 51,52 and 53.Projection 705,706,707,708 and 709 positioned at the both sides of LED is separated out 3 and lays light detection
The space of device, wherein, there is a PD detector 42 side, and opposite side lays two PD detectors 41,43.
In use, in order to ensure that the insertion of housing 30 can be fixed preferably after reading equipment 400, and LED is made
It can be designed with PD detectors with the corresponding region fine registration of test carrier in housing 30 in equipment on blocking element 40
There is card article 406 and 407, the card article 406,407 is located at the both sides of blocking element 40 respectively, and flexible；Meanwhile it is being in the light
The back side of element 40 is also devised with rectangular raised 404, as shown in Figure 6；Correspond, as shown in figure 5, on housing 30
Card article 406 on blocking element can be accommodated by being designed with, the side grooves 32 of 407 ports, and the groove 32 is respectively positioned at housing 30
Two sides；Also, also it is designed with the upper bit 71 of housing and the raised 404 supporting rectangles in the back side of blocking element 40
Groove 34.When housing 30 is inserted in equipment 400, side of the card article 406,407 along housing 30 on blocking element 40 is slided, most
The port of whole card article 406,407 is respectively fallen in corresponding to housing side in groove 32, is fixed and is locked housing 30, meanwhile, housing
Back projection 404 of the upper rectangular recess 34 along blocking element is slided, after housing 30 slides into the fixed position specified, groove
34 end also reaches the end of projection 404, the two tight fit, so that it is guaranteed that accurate when housing uses with coordinative composition of equipments
Degree.
Preferably, also there is circular arc recess 48 on blocking element 40, specified when housing 30 is inserted in equipment 400 and reached
Behind position, the recess 48 contradicts circular adding mouth 31 on housing, so as to further fix the test carrier 10 being located in equipment
With housing 30.It also ensure that the equipment 400 comprising blocking element and the tight fit of housing 30.In another preferable mode, it is
Ensure that housing insertion is read in equipment and reach predetermined position, to include on blocking element 40 right with housing alignment windows 33
The alignment windows 47 answered.In a specific embodiment, the alignment windows 33 on housing can also be set with being directed at window in equipment
After the alignment of mouth 47, reading equipment detection starts.
Fig. 6 be equipment on blocking element schematic rear view, in the figure, it can be seen that with the window 35,36 on housing,
37 correspondences, in equipment blocking element 40 also have 3 with window to deserved window 401,402,403.Set when housing 30 is inserted into
After in standby 400, two-part window is corresponding to be overlapped, and forms passage one by one.These passages can make the light that light-emitting component is sent
Line is irradiated on the region of test carrier, and the light on the region can be made to return on photodetector.
In one specific embodiment, the equipment also includes conducting light paths structure, and the path channels structure is equally such as Fig. 2 and figure
Shown in 3.The main function of conducting light paths structure 200,201：First, illumination can be mapped to greatest extent for light-emitting component 105
In test carrier 10 on specific region（Such as test zone, it is one or several in reference area or testing and control region）,
Without being irradiated on other nonspecific regions；Other conducting light paths structure also allows photoelectric detector 103 to receive to greatest extent
The light of specific region in test carrier 10（Such as test zone, one in reference area or testing and control region or
It is several）, rather than from the light on other unspecific regions.Such as by designing the structure of conducting light paths, only allow one or
Several light-emitting components only irradiate specific test zone without irradiating control area；Only allow simultaneously from test zone or test control
The light that the light in region processed is detected without detecting other test zones by one of photoelectric detector, such as reference area.Such as Fig. 2
Shown in, blocking element 202 encloses with the blocking element 203 in test carrier and test carrier 10 and pcb board 102 in equipment
Form conducting light paths structure 200.More specifically in embodiment, as shown in figure 12, on the blocking element 40 and housing in equipment
The combination of blocking element 38,39,61,62 forms 3 path channels structures 80；Namely window 35 and blocking element in equipment on housing
On window 401 combine, the interference fit that separates with laying LED 51 and PD detectors 43, form a conducting light paths structure
80.Shown in Figure 12, the conducting light paths structure 80 of test zone 130 is surrounded by the part blocking element 75,76 on housing 30 and is set
Standby upper blocking element projection 408,409 is combined, and test zone 130 and pcb board 102 formation one of binding test carrier 10 is complete
Whole conducting light paths structure.The light a that the structure can send LED 51 is only irradiated to the region of window 35 on housing, that is, surveys
The test zone 130 of carrier is tried, and after test zone 130 or film 120 thereon receive light a, reflected, reflected
The light b gone out is received by PD detectors 43, complete on test zone 130 by optical detection；Likewise, window on housing
Mouth 36 is combined with the window 402 of blocking element in equipment, the interference fit with laying LED 52 and PD detectors 42, is formed another
One conducting light paths structure, in another conducting light paths structure, the illumination that LED 52 is sent is mapped to the reference region of test carrier
Domain 140, then reference area reflected, the light after reflection is detected by PD detectors 42, is completed on reference area 140
Pass through optical detection；Window 37 is combined with the window 403 of blocking element in equipment on housing, is examined with laying LED 53 and PD
The interference fit of device 41 is surveyed, forms the 3rd conducting light paths structure, in the structure shown here, the light that LED 53 is sent only is irradiated to
On the control area 150 of test carrier, then by control area the light is reflected, the light of reflection only can be by PD detectors 41
Received, complete on control area 150 by optical detection.
In reading equipment in preferred embodiment, as shown in figure 4, at least one light-emitting component 105 includes three luminous members
Part, each light-emitting component irradiate the specific region of test carrier respectively；At least one photodetector 103 includes three light and detected
Device, for detecting the light of specific region in test carrier.Specifically, the first light-emitting component 105 irradiates test section 130；Second hair
Optical element irradiates reference region 140；And the 3rd light-emitting component irradiates control zone 150.Also, the first detector corresponds to the first hair
Light of the light that optical element, i.e. the first detector the first light-emitting component of detection are sent to test zone back reflection；Second detector
Corresponding to the second light-emitting component, i.e. the second detector detects the light that sends of the second light-emitting component to the light of reference region back reflection；
3rd detector detects the 3rd light sent to the light of control zone back reflection.So, a pair of light-emitting component and photodetector 1
The detection answered, the optical information of regional can be more accurately reacted, ensure the accuracy of detection.In specific embodiment
In, as shown in figure 4, the corresponding photodetector 43 of LED 51, i.e., the light that LED 51 is sent reach test carrier（Test-strips）10
Test zone 130, then, the light reflected on test zone 130 is detected by PD detectors 43, now, what LED 51 was sent
Light is only irradiated in test carrier specific region-test zone, and fixed in 43 detection test carriers of PD detectors
The light that region-test zone is sent.More specifically in embodiment, in the LED and test carrier on blocking element
A certain region it is corresponding, as shown in FIG. 7 and 8, LED 53 is located on window 403 and shell window 37, corresponding to test carrier
Control area 150, the illumination that the LED 53 is sent be mapped to corresponding on control area；Light source led lamp 52 is located at window 402
On shell window 36, corresponding to the reference area 140 of test carrier, the light that LED 52 is sent shines directly into the reference region
On domain 140；Light source led lamp 51 is located on window 401 and shell window 35, corresponding to the test zone 130 of test carrier, sends
Illumination be mapped on test zone.Likewise, photodetector is also one-to-one relation therewith, specific as shown in figure 13, PD
Detector 41 is corresponding with control area 150, the light sent for detection from the control area, and PD detectors 42 and reference region
The correspondence of domain 140, the light sent on the region is detected, PD detectors 43 are corresponding with test zone 130, and detection comes from the region
130 light.
Fig. 3 is a preferred structural representation of the present invention represented embodiment in fig. 2.In Fig. 2 and
There is specific conducting light paths design structure in Fig. 3, in order to reduce domatic 106 pairs of light-emitting components 105 of 110 parts in Fig. 2, or
Interference caused by the reflex for the light that LED 51 is sent, one is configured on equipment blocking element domatic 106
Domatic 2021 and a vertical face 2031 on the housing, the vertical plane 2031 is vertical with the face at the place of test carrier 10, such as
Shown in Fig. 3 and Figure 12.In such structure, because of the presence of vertical plane so that receive the light that LED 51 is sent on test zone
Area increase；And after the light c that LED 51 is sent reaches vertical plane 2031, reflected, the reachable tests of light d of reflection
On region 130, as shown in figure 14, the amount of incident ray on test zone 130 is added so that Detection results are more preferable.
Meanwhile as shown in Fig. 3 and Figure 12, the illumination sent to reduce light-emitting component 105 is mapped to the side of blocking element 101
Directly reflexed to after on wall in photodetector, the structure originally on a vertical plane is changed to close to the area of test carrier part
Domain is recessed backward, forms a groove area 85, i.e., two parts of the conducting light paths structure of neighbouring light-emitting component are not same vertical
On face, the face 2032 on housing is than the face 2022 in equipment away from light-emitting component 105.So, light-emitting component is sent
Stop of the light because having lacked side wall, the specific region being irradiated in test carrier, so as to more effectively utilize light source.I.e.
After light-emitting component 105 or LED 51 emit beam, have some light and be transmitted on each face of the conducting light paths structure,
And reflected, the face of neighbouring light-emitting component 105 or LED 51 can also receive light and be reflected, and the light reflected
Most of line can be shone directly on photodetector 103, can influence testing result；And the face 2032 on housing is further from luminous member
After part 105, a groove 85 is formed between the face 2022 of blocking element in test carrier 10 and equipment, when light-emitting component 105
Or after the light e that sends of LED 51 reaches groove 85, can reflect through the side wall of groove 85, reflection light f arrival test carriers 10
On test zone 130, as shown in figure 15, so, the light not being irradiated in test carrier 10 was both reduced and has directly reflexed to light inspection
Survey on device 103, or PD detectors 43, while increase light is incided on the test zone 130 of test carrier 10 again.
In another preferred embodiment, as shown in Figures 2 and 3, also exist between light-emitting component and photodetector another
Light-blocking member 104.Another light-blocking member 104 can separate light-emitting component and photodetector, so as to avoid on light-emitting component
Shine directly on photodetector, disturb the testing result of photodetector.In specific embodiment, as shown in Fig. 4 and Figure 12, separately
One part 44 and 45 being in the light is distributed on the both sides of LED, separates all LEDs and PD detectors.Another light-blocking part
Part 44,45 is a rectangular lighttight partition, it is preferred that the partition is identical with blocking element material.
The specifically used operation with regard to the reading equipment 300 shown in Fig. 4-13 of the present invention is specifically described below.Do not entering
During row detection, the housing 30 with test carrier 10 adds with reading equipment 400 as split at the adding mouth 31 of housing 30
Add the sample that needs detect, after keeping flat by housing 30 and stand one end time, such as 5 minutes, that holds housing was affectedly bashful position 73, presses
Housing 30 is inserted according to the direction indication of housing upward arrow 74 and read in equipment 400, after in the fully-inserted equipment 400 of housing 30,
After alignment windows 47 are aligned i.e. in the alignment windows 33 and equipment of housing, the reading equipment 300 starts, first LED 51, and 52,
53 light successively, are irradiated to its corresponding region successively：Test zone 130, reference area 140, control area 150, then, respectively
Reflection light on individual region respectively enters its special PD detector 43, and 42,41, complete corresponding detection.
In addition, according to reality, reading equipment disclosed in this invention can also include optical access system, and this system exists
Application number 200910126658.3 or 200410063910.0, have in the Chinese patent application in June 4 2004 applying date in detail
Description.In these disclosed documents each specific embodiment can with scheme disclosed by the invention with reference to and form
The technical approach of the present invention, and as the part of the present invention.
Claims (19)
1. the reading equipment of result of laboratory test in a kind of test carrier, including：
Test carrier；
At least one light-emitting component, send light and be irradiated in test carrier in corresponding one or more areas；
At least one photodetector, for detecting the light sent from one or more areas in the test carrier；
With at least one conducting light paths structure, the light that the conducting light paths structure allows light-emitting component to send can be irradiated to test carrier
On, while allow in one or more areas in test carrier the light sent to be received by photodetector；
At least one light-emitting component includes three light-emitting components, and at least one photodetector includes three light and detected
Device, described at least one conducting light paths structure include three conducting light paths structures；
Three light-emitting components, three photodetectors and three conducting light paths structures are one-to-one relationship, i.e., one luminous
Element, a photodetector and a conducting light paths structure form a conducting light paths system；
Three photodetectors are respectively in the both sides of light-emitting component；
Conducting light paths structure enable to test carrier some or some regions and light-emitting component and photodetector in a phase
To in the space of closing.
2. equipment according to claim 1, it is characterised in that test carrier is coordinated in the form of off-loadable with the equipment.
3. equipment according to claim 2, it is characterised in that at least one conducting light paths structure is by least two parts group
Into this is coordinated at least between two parts in the form of off-loadable.
4. equipment according to claim 3, it is characterised in that wherein, a part of conducting light paths knot at least in two parts
Structure is located in equipment, and another part conducting light paths structure at least in two parts is located in test carrier.
5. equipment according to claim 4, it is characterised in that wherein described another part conducting light paths structure is positioned at survey
In the detection zone for trying carrier.
6. equipment according to claim 4, it is characterised in that wherein described another part conducting light paths structure is also located at
On the detection control area of test carrier or/and reference area.
7. equipment according to claim 4, it is characterised in that test carrier is in a housing, and described at least two
Another part conducting light paths structure in part is located on the housing.
8. equipment according to claim 7, it is characterised in that described housing includes corresponding with test carrier subregion
Window, another part conducting light paths structure in described at least two parts is located on the window.
9. equipment according to claim 8, it is characterised in that on housing window expose test carrier test zone and
Control area.
10. equipment according to claim 9, it is characterised in that window also exposes the reference region of test carrier on housing
Domain.
11. equipment according to claim 10, it is characterised in that the first light-emitting component corresponds to the test section of test carrier
Domain, and it is corresponding with the first photodetector, in the first conducting light paths structure.
12. equipment according to claim 10, it is characterised in that the second light-emitting component corresponds to the reference region of test carrier
Domain, and it is corresponding with the second photodetector, in the second conducting light paths structure.
13. equipment according to claim 10, it is characterised in that the 3rd light-emitting component corresponds to the control zone of test carrier
Domain, and it is corresponding with the 3rd photodetector, in the 3rd conducting light paths structure.
14. equipment according to claim 10, it is characterised in that one light-emitting component is corresponding with a photodetector
The sensitivity of detection can be improved.
15. equipment according to claim 1, it is characterised in that wrapped correspondingly between light-emitting component and photodetector
Another light-blocking member is included, another light-blocking part separates one-to-one light-emitting component and photodetector.
16. equipment according to claim 7, it is characterised in that in each conducting light paths system, the light path in equipment
Conducting structure is domatic adjacent to the face of photodetector；Conducting light paths structure on housing is vertical adjacent to the face of photodetector
Face.
17. equipment according to claim 16, it is characterised in that in each conducting light paths system, neighbouring light-emitting component
Two parts of conducting light paths structure not on same vertical plane, part on housing than in equipment partially away from hair
Optical element.
18. according to the equipment described in one of claim 1-8, it is characterised in that also including blocking element, the blocking element can
Stop that external light source enters in the equipment；And formed can stop external light source enter test carrier on test zone and/or
Reference area and/or the structure for detecting control area.
19. equipment according to claim 18, it is characterised in that the blocking element of part forms conducting light paths structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110365514.3A CN103115898B (en) | 2011-11-17 | 2011-11-17 | The reading equipment of result of laboratory test in a kind of test carrier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110365514.3A CN103115898B (en) | 2011-11-17 | 2011-11-17 | The reading equipment of result of laboratory test in a kind of test carrier |
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| CN103115898A CN103115898A (en) | 2013-05-22 |
| CN103115898B true CN103115898B (en) | 2018-01-16 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11860085B2 (en) * | 2019-01-10 | 2024-01-02 | Zhejiang Orient Gene Biotech Co., LTD | Reading apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105911267A (en) * | 2016-05-26 | 2016-08-31 | 镇江索乐电子科技有限公司 | Urine analyzer light control device |
| CN108593259B (en) * | 2018-03-26 | 2023-12-22 | 镇江市建设工程质量检测中心有限公司 | Door and window daylighting performance check out test set |
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| AU2004200781B2 (en) * | 2000-02-02 | 2005-06-16 | Otsuka Pharmaceutical Co., Ltd. | Test strip measuring device |
| CN1573316A (en) * | 2003-06-04 | 2005-02-02 | 因韦尔尼斯医药瑞士股份有限公司 | Optical arrangement for assay reading device |
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