CN103110961A - Preparation method of high-definition endoscope mucus-removal defoaming composite preparation - Google Patents
Preparation method of high-definition endoscope mucus-removal defoaming composite preparation Download PDFInfo
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- CN103110961A CN103110961A CN2012105043485A CN201210504348A CN103110961A CN 103110961 A CN103110961 A CN 103110961A CN 2012105043485 A CN2012105043485 A CN 2012105043485A CN 201210504348 A CN201210504348 A CN 201210504348A CN 103110961 A CN103110961 A CN 103110961A
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Abstract
The invention discloses a preparation method of a high-definition endoscope mucus-removal defoaming composite preparation, which comprises the following steps: simultaneously pouring chymotrypsin, sodium bicarbonate powder and dimethyl silicon oil powder into a graduated cuvette, adding warm boiled water, and completely dissolving by stirring. The invention solves the problem that defoaming and mucus protein removal can not be completed at the same time in gastrointestinal tract detection process of the existing high-resolution endoscope, increases the detection rate of minimal diseases, and enhances the inspection visual field definition and inspection efficiency of the endoscope. The clinical practice proves that the high-definition endoscope mucus-removal defoaming composite preparation can satisfy the requirements, can effectively avoid missed diagnosis, facilitates the early treatment of patients, reduces the subsequent treatment cost for the patients, and has favorable economic benefit.
Description
Technical field
The present invention relates to the preparation method that a kind of high definition scope removes mucus froth breaking compound formulation, be mainly used in dispelling in high definition endoscopy and therapeutic endoscopy mucus and foam in gastroduodenal.
Background technology
Detect gastroenteric tumor with the high definition scope in medical treatment and clear and definite tumor invasive depth is a kind of process useful, yet in gastrointestinal tract, mucus and foam usually affect the visual field of scope, cause the minimal disease recall rate to descend and the review time prolongation.Dimethicone is a kind of infusion of dispelling that reduces bubble surface tension force, the gastrointestinal foam is merged, thereby improve Endoscopic definition, improve diagnosis and improve Endoscopic satisfaction, but it can't eliminate the mucus protein in gastrointestinal tract.Chymotrypsin has the effect of endopeptidase, the peptide chain of protein macromolecule can be cut off, and can with some hydrolysis of lipid, can effectively decompose by above-mentioned mechanism the mucus protein that coat of the stomach adheres to.But without the effect that reduces foam surface tension force, can't eliminate gastrointestinal tract foam and bubble because of it, utilization can't meet clinical needs separately.Seek for this reason a kind of can either eliminate foam can dispel again the medicine of mucus protein become in clinical position in the urgent need to.
Summary of the invention
The technical problem to be solved in the present invention is: in order to solve the difficulty that in the above-mentioned background technology, existing high definition scope exists when detecting gastrointestinal tract, provide a kind of high definition scope to remove mucus froth breaking compound formulation, can either eliminate foam and can dispel mucus protein again.
The technical solution adopted in the present invention is: a kind of high definition scope goes the preparation method of mucus froth breaking compound formulation: pour simultaneously Chymotrypsin, sodium hydrogen carbonate powder, dimethyl-silicon oil meal into scale cuvette, add warm water, stirring makes to dissolve fully and gets final product.
Further, the percentage by weight raw material of compound formulation of the present invention is prepared as: Chymotrypsin: 0.01-0.02%, sodium hydrogen carbonate powder: 0.1-0.2%, dimethyl-silicon oil meal: 1.23-2.46%, pure water: 97-99%.
Further, Chymotrypsin of the present invention has endopeptidase and lipase effect: the peptide chain of protein macromolecule can be cut off, become the peptide of molecular weight, or act on the protein molecular peptide end of the chain, aminoacid is told; And can be with some hydrolysis of lipid.Decompose by this effect the mucus that coat of the stomach adheres to; Dimethicone is foam reducing composition, and the simethicone surface tension is little, can change bubble surface tension force, it is broken, thereby the gas that stores in the gastrointestinal tract inner foam is discharged, can improve gastroscopic definition, more clearly show the fine structure on gastrointestinal tract mucosa surface.
The invention has the beneficial effects as follows: the invention solves existing high definition scope exists can not eliminate simultaneously foam and dispel the problem of mucus protein when detecting gastrointestinal tract, improved the recall rate of minimal disease, improve simultaneously definition and the checking efficiency in the endoscopy visual field, we find that by clinical practice this product can satisfy above-mentioned requirements, can effectively avoid failing to pinpoint a disease in diagnosis, race against time for the patient carries out the early treatment, reduce patient's successive treatment expense, obtain good economic benefit ratio.
The specific embodiment
The present invention is further detailed explanation in conjunction with the preferred embodiments now.
A kind of high definition scope of the present invention removes the embodiment of the preparation method of mucus froth breaking compound formulation, and this product is compound preparation, and its component is: every box is comprised of A, B, each 1 bag of C, and A comprises: Chymotrypsin 8000u is a kind of protease that extracts in Pancreas Bovis seu Bubali; B comprises: sodium hydrogen carbonate powder 0.1g; C comprises dimethyl-silicon oil meal 0.615g, this product 1 box (including A, B, each 1 bag of C) was got in gastroscopy in front 5-10 minute, pour in the lump in band scale cuvette respectively wrapping medicated powder in box, add warm water to 50ml, stirring makes dissolving fully, take and get final product, the percentage by weight raw material of compound formulation of the present invention is prepared as: Chymotrypsin: 0.01-0.02%, sodium bicarbonate: 0.1-0.2%, dimethyl-silicon oil meal: 1.23-2.46%, pure water: 97-99%.
Just the specific embodiment of the present invention of describing in above description, various not illustrating is construed as limiting flesh and blood of the present invention, the person of an ordinary skill in the technical field after having read description can to before the described specific embodiment make an amendment or be out of shape, and do not deviate from essence of an invention and scope.
Claims (2)
1. the preparation method that the high definition scope removes mucus froth breaking compound formulation, is characterized in that: pour simultaneously Chymotrypsin, sodium hydrogen carbonate powder, dimethyl-silicon oil meal into scale cuvette, add warm water, stir and make dissolving fully.
2. a kind of high definition scope as claimed in claim 1 preparation method of removing mucus froth breaking compound formulation, it is characterized in that: the percentage by weight raw material of described compound formulation is prepared as: Chymotrypsin: 0.01-0.02%, sodium hydrogen carbonate powder: 0.1-0.2%, dimethyl-silicon oil meal: 1.23-2.46%, pure water: 97-99%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012105043485A CN103110961A (en) | 2012-11-30 | 2012-11-30 | Preparation method of high-definition endoscope mucus-removal defoaming composite preparation |
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| CN2012105043485A CN103110961A (en) | 2012-11-30 | 2012-11-30 | Preparation method of high-definition endoscope mucus-removal defoaming composite preparation |
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| CN103110961A true CN103110961A (en) | 2013-05-22 |
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Cited By (5)
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| CN106492231A (en) * | 2016-11-03 | 2017-03-15 | 山东威高药业股份有限公司 | A kind of lidocaine hydrochloride tract lubricates infusion of dispelling |
| CN109200278A (en) * | 2018-10-08 | 2019-01-15 | 毛玉坤 | Hysteroscope removes mucus defoaming agent and preparation method thereof |
| CN110327471A (en) * | 2019-01-24 | 2019-10-15 | 北京歌斐医疗器械有限公司 | A kind of endoscopy spasmolysis defoaming agent and preparation method thereof |
| CN115400228A (en) * | 2022-08-30 | 2022-11-29 | 中国人民解放军总医院第二医学中心 | Formula of anti-flocculation defoaming agent in gastroscopy |
| CN117959256A (en) * | 2024-02-05 | 2024-05-03 | 山东序列生物科技有限公司 | Simethicone powder and preparation method and application thereof |
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| CN100594942C (en) * | 2008-04-30 | 2010-03-24 | 李丽君 | Method for preparing cellulose contrast medium for stomach and intestine ultrasonic imaging |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492231A (en) * | 2016-11-03 | 2017-03-15 | 山东威高药业股份有限公司 | A kind of lidocaine hydrochloride tract lubricates infusion of dispelling |
| CN106492231B (en) * | 2016-11-03 | 2019-09-20 | 山东威高药业股份有限公司 | A kind of lidocaine hydrochloride cavity lubrication is dispelled infusion |
| CN109200278A (en) * | 2018-10-08 | 2019-01-15 | 毛玉坤 | Hysteroscope removes mucus defoaming agent and preparation method thereof |
| CN110327471A (en) * | 2019-01-24 | 2019-10-15 | 北京歌斐医疗器械有限公司 | A kind of endoscopy spasmolysis defoaming agent and preparation method thereof |
| CN110327471B (en) * | 2019-01-24 | 2021-08-27 | 奥纳斯(北京)医药科技有限公司 | Antispasmodic agent for endoscopy and preparation method thereof |
| CN115400228A (en) * | 2022-08-30 | 2022-11-29 | 中国人民解放军总医院第二医学中心 | Formula of anti-flocculation defoaming agent in gastroscopy |
| CN117959256A (en) * | 2024-02-05 | 2024-05-03 | 山东序列生物科技有限公司 | Simethicone powder and preparation method and application thereof |
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Application publication date: 20130522 |