CN103100017B - Traditional Chinese medicine health care product for relieving muscle and bone pain and arthralgia and preparation method thereof - Google Patents

Abstract

The invention provides an external traditional Chinese medicine health care product for relieving muscle and bone pain and arthralgia. The traditional Chinese medicine health care product comprises the following raw materials in parts by weight: 10-20 parts of illicium verum, 10-20 parts of Szechuan lovage rhizome, 10-20 parts of salvia miltiorrhiza, 10-20 parts of angelica dahurica, 10-20 parts of red flower, 10-20 parts of caulis spatholobi, 10-20 parts of lycopodium clavatum, 10-20 parts of resurrection lily rhizome, 10-20 parts of polygonum cuspidatum, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of manchurian wild ginger, 10-20 parts of rhizoma drynariae, 10-20 parts of geranium wilfordii, 10-20 parts of rhizoma bletillae, 10-20 parts of garden balsam stem, 10-20 parts of myrrh, 10-20 parts of frankincense, 10-20 parts of teasel root, 10-20 parts of notopterygium root and 10-20 parts of ground beeltle. The traditional Chinese medicines with the effects of tonifying kidney and strengthening bones and promoting blood circulation to remove blood stasis have a certain curative effect on joints, and can improve local vertebrobasilar dysfunction, enhance regional cerebral blood flow, promote bone trabecula regeneration, shrink cystic change, harden bone absorption, repair cartilage parts and restore blood flow amyotrophy.

Description

A kind of Chinese medicine health care product of alleviating bones and muscles pain, arthralgia and preparation method thereof

Technical field

The present invention relates to contain the medical health product that derives from plant, animal or mineral component, particularly a kind of Chinese medicine health care product of alleviating bones and muscles pain, arthralgia and preparation method thereof.

Background technology

The defect of this old people Chang You of bones and muscles pain but spreads in Chinese middle-aged adults as infectious disease in recent years.Before computer, sat a whole day neck pain; In air-conditioned room, treated for a long time lumbago; Mouse is used many, wrist pain; Swim once in a while, pain in my shoulder; Climb the mountain and come back, knee pain ... people is not old, and why " muscles and bones " expert that first declines points out, lack motion, incorrect posture, and athletic injury is the main cause that causes many youngster whole bodies " bones and muscles pain ".And whole-body muscle joint also wind-engaging, cold, summer-heat, wet, dry, fiery " six climate exopathogens " invasion and attack or wound, chronic strain, transdermal is pathogenic and form " six poison " to the marrow, be exactly we usually said " bone is malicious "." bone poison " long-term existence forms " place poison " on bone and periosteum.Place poison makes bone and soft hyperemia, edema, adhesion, the contracture repeatedly of knitting of periarticular, thereby cause local blood circulation obstacle, produce a large amount of acidic materials and stimulate blood vessel, infringement muscular tissue, shows as muscle muscles and bones joint aches, numb, swelling, even red and swollen distortion, severe one can cause the destruction of joint sclerotin, and joint deformity be can't take care of oneself.Bones and muscles pain is the clinically important form of expression of rheumatic osteopathia, process emphatically.We know a hawk from a handsaw, and motion must first fully be carried out warm-up before, movable good joint.Otherwise be easy to cause muscle sprain, the damage of the healths such as articular sprain, causes fracture what is more.

Liver governing tendons, spleen governing muscles extremity, it is closely related with liver spleen, QI and blood, Rong Wei that function of joint maintains." limbs damage in outside, QI and blood is hindered in interior, Rong Wei does not pass through to some extent " so that synovial membrane damage, water seepage liquid, damp is detained, so just produce arthritis, the common arthritis such as synovitis.

Arthritis is a kind of common autoimmune disease that joint tissue chronic inflammatory disease is main manifestations of take.Pathological changes joint main manifestations is inflammatory cell infiltration, the cartilage that synovial hyperplasia, pannus form and cause thus and the damage of bone.Arthritis belongs to Chinese medicine " numbness is sick " category.In < <, through > >, think, element body deficiency of qi and blood, wind, cold, wet three gas heterozygosis are invaded human body in an opponent's defence, multiple abscess muscles and bones blood vessels, fighting and tie in joint, is the Etiological pathogenesis of numbness disease.So the heresy that wind and cold is damp and hot is this pathogenetic external condition, and insufficiency of vital energy and blood, battalion defending the intrinsic factor that imbalance is only primary disease.Treatment primary disease is worked as with functions dispelling wind and clearing away cold, removing dampness, and benefiting QI for activating blood circulation dredging collateral is rule for the treatment of.Knee has many synovial bursas relevant with tendon slide construction with joint motion, what have communicates with joint, isolated existence thing have, the most ill synovial bursa is prepatellar bursa, under kneecap, synovial bursa gastrocnemius, knee suffer long-term external force friction or compressing, all can cause that synovial membrane is congested, edema and serosity ooze out, form acute synovial bursa hydrops, cyst wall and thicken and the pathological change such as joint accretion.The synovial layer blood fortune of capsula articularis genus is abundant, and distribution is larger, is one of kneed important structure.Synovial cell can secrete synovial fluid, keeps the lubricated of articular surface.Mostly the generation of gonarthromeningitis be due to knee joint acute injury, or the synovial membrane aseptic inflammation causing due to chronic strain, hyperosteogeny and rheumatism factor.Its pathological change mainly contains two: one, vasodilation, the hyperemia of territory, lesion synovial membrane, and blood plasma, erythrocyte, leukocyte etc. exosmose, and produce a large amount of transudates; The 2nd, synovial cell enlivens hypertrophy, and emiocytosis is extremely vigorous, produces a large amount of mucoitins, arthroedema, joint pressure increases, and hinders lymphsystem circulation, intraarticular acidic metabolite is piled up, retained so for a long time, can increase the weight of synovial membrane inflammation and make state of an illness vicious cycle.Stage synovial membrane thickens, and is adhered, and articular cartilage atrophy, causes knee joint disorders.

Motherland's medical science is thought caused by liver and kidney deficiency, and muscles and bones mistake is supported, and space between skin and muscles is hollow, wind and cold is mixed extremely, the blood vessels that stagnate, the not flourish muscle of blood, muscle arteries and veins contraction is anxious, wants bone and muscle strengthening, invigorating the liver and kidney, will make local vascular dilation, blood fortune strengthens, metabolism strengthens, and immunity improves, thereby makes pain relief, promote the absorption of blood stasis, play relaxing muscles and tendons and activating QI and blood in the collateral, consolidate effect eliminating evil, reducing swelling and alleviating pain.The traditional Chinese medical science thinks, the exopathogen invasion and attack human bodies such as wind, cold, wet, heat, impatency meridians, QI and blood can not pass unimpeded, cause muscles and bones, joint etc. ache, numb, weighing, activities adverse, even arthroncus is scorching hot, so that stagnation of QI and blood may bring about pain.Simple oral medicinal herb is worthless, and necessary multiple maneuver combined treatment, just can reach the effect of getting twice the result with half the effort, wherein massage, and acupuncture, hot compress is all good selection.In modern medicine, treat the medicine of orthopaedic disease normally containing estrogenic chemicals, during clinical use, drug side effect is large, and Chinese medicine is because of its special effect and the little favor of firmly getting doctor and patient of side effect.

Summary of the invention

Technical problem to be solved by this invention is, treats the medicine of the diseases such as bones and muscles pain, orthopaedics joint normally containing the chemicals of hormone in modern medicine, and during clinical use, drug side effect is large; And the invention provides a kind of bone and muscle strengthening, and making local vascular dilation, blood fortune strengthens, and metabolism strengthens, thereby makes pain relief, promotes the absorption of blood stasis, plays relaxing muscles and tendons and activating QI and blood in the collateral, consolidates health product eliminating evil, reducing swelling and alleviating pain.

For solving the problems of the technologies described above, the invention provides a kind of alleviation bones and muscles pain, the Chinese medicine health care product of arthralgia, in described Chinese medicine health care product, the parts by weight of various raw materials can be: 10～20 parts of Fructus Anisi Stellatis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Lycopodiis, 10～20 parts of Rhizoma Kaempferiae, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Asaris, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Herba Erodiis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Herba speranskiae tuberculataes, 10～20 parts of Myrrhas, 10～20 parts of Olibanums, 10～20 parts of Radix Dipsacis, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Eupolyphaga Seu Steleophagas.

Described alleviation bones and muscles pain, the Chinese medicine health care product of arthralgia, described in it, in Chinese medicine health care product, the parts by weight of various raw materials can be preferably: 10～15 parts of Fructus Anisi Stellatis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts, Flos Carthami, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Lycopodiis, 10～15 parts of Rhizoma Kaempferiae, 10～15 parts of Rhizoma Polygoni Cuspidati, 10～15 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Asaris, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Herba Erodiis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Herba speranskiae tuberculataes, 10～20 parts of Myrrhas, 10～20 parts of Olibanums, 10～20 parts of Radix Dipsacis, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Eupolyphaga Seu Steleophagas.

Described alleviation bones and muscles pain, the Chinese medicine health care product of arthralgia, described in it, in Chinese medicine health care product, the parts by weight of various raw materials can also be preferably: 10～20 parts of Fructus Anisi Stellatis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Lycopodiis, 10～20 parts of Rhizoma Kaempferiae, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Herba Asaris, 10～15 parts of Rhizoma Drynariae, 10～15 parts of Herba Erodiis, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Herba speranskiae tuberculataes, 10～15 parts of Myrrhas, 10～15 parts of Olibanums, 10～15 parts of Radix Dipsacis, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Eupolyphaga Seu Steleophagas.

The Chinese medicine health care product of described alleviation campaign posterior joint pain, described in it, the dosage form of health product can be: liniment, ointment, plaster, cream, spray or patch.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of alleviating the Chinese medicine health care product of bones and muscles pain, arthralgia, preparation process when described health product are liniment:

According to described umber, by raw material soak with ethanol, rear 60～85 ℃ of heat are extracted 3 times, each 1 hour; Ethanol used is 10 times of amounts of described raw material gross weight; The concentrated ethanol extract of heating, is concentrated into relative density and is 1.06 concentrated solution, stand for standby use; Medicinal residues are dropped into pulverizer and pulverize, put into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, flood 10～15 days with ethanol is common, the liquid having flooded and medicinal residues are carried out to squeeze and filter, after separation, get filtrate, then mixed with aforementioned concentrated solution; Described mixed liquid heating is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grind to form fine-powdered with Rhizoma Et Radix Notopterygii is mixed, mix vaseline and make liniment.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of alleviating the Chinese medicine health care product of bones and muscles pain, arthralgia again, and the dosage form of described health product is unguentum, and preparation method comprises:

A. the crude drug of getting above-mentioned ratio of weight and number is put into Oleum Sesami and is soaked;

B. more soaked crude drug is heated and tempered in Oleum Sesami;

C. medicine oil is put into in the Plumbum preparatium of having fried and stir into paste;

D. the ointment having refined is put into releasing fire-toxin in cold water.

In described step a, can add in the Oleum Sesami of 5-10 times of weight portion and soak 7-10 days by the crude drug of described ratio of weight and number.

In described step b, can be by the soaked crude drug heating extraction of Oleum Sesami, big fire is boiled, and after Oleum Sesami boiling, firepower reduces, and endures to crude drug appearance and is dark brown, and inner coke yellow, pulls medicinal residues out, medicine oil is continued to temper, and constantly stir, and refining is to dripping into pearl.

In described step c, Plumbum preparatium can be fried to dark yellow, remove moisture, cross 100 mesh sieves and remove impurity; Plumbum preparatium is added in the medicine oil having refined, constantly stir, become the thick paste of black.

In described steps d, can soak 5-10 days by the slightly cold rear impouring cold water of the black thick paste having refined, change water every day once, releasing fire-toxin.

These health product adopt pure traditional Chinese medicine to form, there is bone and muscle strengthening, invigorating the liver and kidney, make local vascular dilation, blood fortune strengthens, and metabolism strengthens, and immunity improves, thereby make pain relief, promote the absorption of blood stasis, play relaxing muscles and tendons and activating QI and blood in the collateral, consolidate effect eliminating evil, reducing swelling and alleviating pain, and safety, without obvious toxic-side effects.The present invention adopts the Chinese medicine of invigorating the kidney and strengthening the bones, function of promoting blood circulation to disperse blood clots to have certain curative effect to bones and muscles pain, joint, can improve local intra-arterial blood supply dysfunction, strengthen regional blood flow, promote bone trabecula regeneration to form, cryptomere changes dwindles, sclerotic bone absorbs, and repair at cartilage position, and unobstructed vessel amyotrophy recovers.The advantages such as compared with prior art teach, this technology has convenient drug administration, and medicament is easy to manufacture, with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, coordinates acupuncture, massage, and the modes such as massage are used and are got twice the result with half the effort; And safety, toxic and side effects is little, easy to use, and healing time is short, after curing, is difficult for recurrence.Can create good social value and economic interests.

The specific embodiment

The card of bones and muscles pain, though ancients have the name of five kinds of arthralgia, the main pain of numbness person, thus control the side of numbness, standby and smart, if can firmly believe syndrome, belong to arthromyodynia, with the side of five kinds of arthralgia, invariably the standing and see the magical effect of throwing.Only because of the outer pain card of five kinds of arthralgia, more than five kinds of arthralgia.The pain that has the deficiency of vital energy not transport, has the pain that blood deficiency can not nourishing muscle and tendon, have typhoid fever pestilence first ache, have teenager to be subject to hard work too far, and to the pain in middle age, have the pain of traumatic injury.The pain of husband's muscles and bones, too numerous to enumerate.The pain that has again internal injury, the pain of diseases caused by exogenous pathogenic factor, has the not pain of interior wound.QI and blood is two loses, hard work is excessive, and also, typhoid fever pestilence is first for the pain of this internal injury, the pain of these diseases caused by exogenous pathogenic factor also, traumatic injury, this not in wound pain also.Card is both different, and method for the treatment of is different, sees clearly disease, what has been controlled difficult.Only syndrome is not clear, fastens one person's story upon another person, and Zhu's purple is obscured, random test point moxibustion, and absurd dispensing bait, it is heavy that the lighter becomes, and severe one is lethal, repents later, has become that what's done can't be undone.Grandson true man's cloud: " gallbladder is wanted large and heart wish is little, intelligence wish circle and row wish side." eastern wall cloud: " doctor anticipates also, and gods are exquisite, deposit its people." cure together, can count language by ripe this, also can use infinite.Arthralgia, common body constitution is wet person how, clinical take hydrarthrosis, swelling, stretch bend difficulty, pain is not acutely main manifestations, belongs to the wet category of Chinese medicine arthromyodynia folder.When knee joint is directly subject to violence strike or is subject to indirect violence causing sprain of knee joint, long-term heavy burden chronic strain, or the mechanics of limbs own is disorderly, strenuous exercise or super-strength training, incorrect activity posture, rough treatment skill or operation on joint etc. all can touch or injure synovial membrane and produce unique inflammatory reaction, cause that synovial membrane damage is congested, swelling, synovial cell produces a large amount of synovial fluid, and the intraarticular hydrops that arrives.

Arthritis belongs to the categories such as Chinese medicine " arthromyodynia ", " arthroncus of knee ", the primary disease initial stage is be obstructed (acute) or wind, cold, wet, evil three gas heterozygosis (chronic) blood-stasis internal-depressions of menolipsis arteries and veins in traumatic stasis, QI and blood must not pass unimpeded, yang-energy must not compress, the wet conflux note joint of stopping of water, damp-stagnancy and heat-transformation, damp and hotly fight mutually, due to the stagnant hydrops of the stasis of blood, therefore treatment is upper, take blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, channels sootheing and network vessel quickening, reducing swelling and alleviating pain as main.Treatment by Chinese herbs primary disease, should set about from two aspects: the one, solve joint blood stasis, the 2nd, suppress synovial membrane abnormal secretion, this is the key point for the treatment of primary disease.< < Plain Questions the five internal organs generate piece of writing > > and say: " foot is subject to the walking of blood energy, and the palm can be held by blood, refers to be subject to blood to take the photograph." liver governing tendons, spleen governing muscles extremity, it is closely related with liver spleen, QI and blood, Rong Wei that function of joint maintains." limbs damage in outside, QI and blood is hindered in interior, Rong Wei does not pass through to some extent " synovial membrane damage, water seepage liquid, damp is detained.Treat and take QI invigorating to adjust Rong Wei, the diuretic bone and muscle strengthening of wetting.

Gonitis is many by due to chronic strain or damage, also has because of acute synovitis and deals with improperly and form chronic states.Joint motions are by myotasis, lubricated by synovial membrane secretion synovial fluid, and muscle, muscles and bones, synovial fluid moisten foster by QI and blood.Therefore suitable acupoint injection therapy and manual massage can play blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, and reducing swelling and alleviating pain effect, can improve blood circulation, promotes the effect that cellular metabolism and transudate absorb.In addition, local fixing braking makes to suffer from knee joint and is had a rest, and reduces pessimal stimulation, accelerates synovial membrane reparation; Knee-joint anatomy is complicated, and function of joint Operations Requirements is high, the regression of synovial membrane, plumpness, be adhered, fibrosis, contracture etc., often cause the contracture of quadriceps femoris, function of joint moving obstacle, even tetanic, stiff.Therefore, row quadriceps femoris and knee joint function exercising are also the keys for the treatment of primary disease early.Quadriceps femoris functional exercise, can effectively prevent that periarticular is adhered, amyotrophy, increase local blood circulation, accelerate metabolism, thereby be conducive to nutrition and the reparation of knee joint synovial membrane and cartilage thereof, eliminate local inflammation, be conducive to the absorption of transudate, promote swelling to disappear.

In side with Radix Saposhnikoviae, dispelling cold and removing dampness, to eliminate external heresy, dredging the meridian; With Fructus Anisi Stellati, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, to eliminate the stasis of blood stagnant, dredging the meridian; With Radix Paeoniae Alba righting benefiting QI and nourishing blood, make healthy energy internal memory, pathogenic factor gradually moves back; From modern medicine angle, we have the function of antiinflammatory, analgesia, adjusting immunity.Wherein Fructus Anisi Stellati, Rhizoma Chuanxiong, there is the local microcirculation of improvement, suppress humoral immunization, eliminate local inflammation; And Radix Salviae Miltiorrhizaes etc. can regulate cellular immune function.All medicines share, and treating both the principal and secondary aspects of a disease had both been focused on integral macroscopic adjustment, pay attention to again local microcosmic treatment, have dialectical and differential diagnosis of diseases, and the local and whole feature combining, therefore can obtain good clinical efficacy.In side, Caulis Spatholobi, Flos Carthami, Fructus Anisi Stellati, Rhizoma Chuanxiong, Olibanum, Myrrha, Herba Erodii, Herba speranskiae tuberculatae blood circulation promoting and blood stasis dispelling, dispel blood stasis, promotes blood stasis to absorb; Eupolyphaga Seu Steleophaga has the merit of warming YANG activating QI to promote diuresis, detumescence; Heat clearing white peony promoting diuresis to eliminate damp pathogen, eliminates hydrops, suppresses the effect of synovial membrane abnormal secretion; Herba Lycopodii, the pain relieving of Radix Dipsaci channels sootheing and network vessel quickening, reach not effect bitterly of general rule.All methods are share, and can remove joint synovitis disease, eliminate hydrarthrosis, promote function of joint to improve, and reach the merit for the treatment of both the principal and secondary aspects of a disease.

Fructus Anisi Stellati: be the fruit of Winteraceae plant Fructus Anisi Stellati, cure mainly colic of cold type stomachache, chills and pain of the waist and kness, gastrofrigid vomiting, epigastric pain, the disturbance of lower legs due to pathogenic cold and dampness etc.The < < book on Chinese herbal medicine > > that looks for the truth: Fructus Anisi Stellati, contained according to book, merit specially enters the dry kidney of liver, all chronic diseaseses and see cholera.Colic of cold type, swelling of the vulva, lumbago, and dry, beriberi caused by pathogenic damp, and Liver Channel asthenic fire, with it, take all effective from upper left punch face person.Lid Fructus Foeniculi and Cortex Cinnamomi, Fructus Evodiae, genus cloudy dry medicine of fainting all, but cornel is walked the intestines and stomach, Gui Zeneng enters Liver and kidney, this body gently can enter meridians also.Must introduce kidney for salt, send YIN pathogen, therefore it is effective to control hernia.More than chew carefully and examine anistree fennel taste, though it fragrantly has, its taste is very sweet, it is warm in nature and not strong, than tastes such as Fructus Evodiae, Folium Artemisiae Argyis, more belongs to different, if like the sweet many tastes of anistree Fructus Anisi Stellati, and meaning can remove chronic diseases, is similar to manage genus and hinder.Saline is fried use, obtains wine good.

Eupolyphaga Seu Steleophaga has the effect of removing blood stasis, reunion of fractured tendons and bones, and has thrombolytic mechanism.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.Its cold in nature, salty in the mouth, poisonous, can enter conscience spleen three warps, there is removing blood stasis, removing mass, dredging collateral, reason wound and reunion of bone, reducing swelling and alleviating pain, the stimulating milk secretion effect such as stimulate the menstrual flow, be treating blood disorders traumatology key medicine, be applicable to the diseases such as cancer abdominal mass is gathered, amenorrhea due to stagnation of blood, postnatal blood stasis stomachache, traumatic injury, swollen and rigid tongue, congenital deformity of the tongue.< < Medical Treasures of the Golden Chamber > >: control the patient suffering from five overstrains being extremely weak and thin, abdominal distention, can not diet, dyspepsia, sorrow, impairment of fluid-retention, injury due to sexual activity, internal impairment caused by hunger, impairment caused by overstrain, meridians Rong Wei impairment of QI, blood stasis in the interior, squamous and dry skin, dark complexion around the eyes.Easing middle-JIAO and tonifying for deficiency.

Rhizoma Chuanxiong is pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.< < herbal classic > > carries it: main apoplexy enters brain headache, arthralgia due to cold, and clonic spasm of the muscle emergency, gold wound, married woman's blood closes loss of fecundity.< < does not record > > and carries it: " except cold moving in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle; before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors; soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.The bun of < < medical center wants > > to carry it: hard kidney, and strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.< < book on Chinese herbal medicine converges says > >: Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth do not fall, dead fetus in the uterus, is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood chamber, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, are cards of disharmony between QI and blood all, and non-Flos Carthami can not be adjusted.

Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.For headache due to common cold, rubella pruritus.Control exterior syndrome due to wind-cold, headache general pain, aversion to wind and cold person, Chang Peiwu Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis etc.; Control diseases caused by exogenous pathogenic factor rheumatism, headache as wrap up in, heavy sensation of the body acroesthesia person, be equal to use with Rhizoma Et Radix Notopterygii, Rhizoma Ligustici; Control rubella pruritus, polygamy 5 Radix Sophorae Flavescentiss, Herba Schizonepetae, Fructus Anisi Stellati etc.For rheumatic arthralgia.Be applicable to anemofrigid-damp arthralgia, arthrodynia of extremities, muscle arteries and veins contraction urgency person, often coordinate Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, Rhizoma Curcumae Longae.

Herba Erodii is bitter, be pungent, put down.Return liver, kidney, large intestine channel, function cures mainly dispels rheumatism.For rheumatic arthralgia.The disease such as numb limbs and tense tendons, articular instability, alone effective, be decocted in water for oral dose or endure cream and use; As medicines such as compatibility Ramulus Cinnamomi, Fructus Anisi Stellati, Flos Carthami, Radix Paeoniaes, can strengthen the effects such as promoting blood circulation, dredging meridian and relieving pain.

The micro-hardship of Herba Lycopodii, pungent, temperature.Return liver,spleen,kidney warp.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.Micro-hardship, pungent, temperature.Return liver,spleen,kidney warp.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.The standby > > that wants of the SHENGCAO property of medicine: (Herba Lycopodii) " detumescence, except pathogenic wind-warm.Infusing drugs in wine drink, relaxing muscles and tendons and activating QI and blood in the collateral.It effects a radical cure depressed pain, damage, and internal injury caused by metallic tool, removes phlegm and relieving cough, controls skin ulcer cellulitis soldier brothers.”

Herba speranskiae tuberculatae is Phrymaceae Herba speranskiae tuberculatae platymiscium Herba speranskiae tuberculatae (Latin formal name used at school: Phryma leptostachya L.) have another name called distiller’s yeast grass, Staggergrass etc.The part of being used as medicine is plant herb.Herba speranskiae tuberculatae is sweet, pungent, temperature.Enter lung, Liver Channel.Function cures mainly expelling wind and removing dampness, removing toxic substances pain relieving.For rheumatic arthritis; Sore swollen toxin is controlled in external.Join Herba Lycopodii, treating the liver kidney deficiency, muscles and bones mistake is supported, joint stuffiness, numb limbs and tense tendons, muscles and bones contracture, has the effect that the muscle of stretching is deep.Join Caulis Spatholobi, the liver and the kidney tonifying, promoting blood circulation and stopping pain, it is the most suitable that lingering arthralgia belongs to empty person.

Rhizoma Drynariae is bitter, temperature.Return kidney, Liver Channel.The kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.The kidney invigorating, invigorates blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.< < property of medicine opinion > >: " poison in main bone, wind blood pain, five kinds of over strain six types of severe debility disease, hands is not received, upper heat and lower cold." < < book on Chinese herbal medicine positive > >: " treats bone poison of being possessed, wind heat pain, or diseases caused by exogenous pathogenic factor rheumatism, so that the weak pain of two flaccidity of the lower limbs.

Rhizoma Kaempferiae, calls husky Rhizoma Zingiberis Recens, mountain is peppery.With rhizome, be used as medicine, warming middle-JIAO for eliminating dampness, promoting the circulation of QI to relieve pain.Cure mainly acute gastroenteritis, dyspepsia, cold syndrome of the stomach pain, toothache, rheumatic arthritis, traumatic injury.Circulation of qi promoting warming middle-JIAO, helps digestion, pain relieving.For septum pectorale distension, coldness and pain in the epigastrium, diet does not disappear.Effect rhizome decoct 0.25-0.75% concentration to intestinal smooth is excitation to guinea pig in vitro intestinal tube.Concentration increases to 1-1.25% and occurs inhibitory action; The saturated aqueous solution of its volatile oil and the effect of decoct are similar.

Radix Dipsaci, Chinese medicine name, is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, because energy " synthetism of continuous folding " is gained the name.Excavate autumn, removes root head and fibrous root, is dried to half-driedly with low baking temperature, banks up " diaphoresis " when the inner virescence, then dry.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) ached; antiabortive, controls married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood; the stillborn fetus that falls, and the cough-relieving hemoptysis of coughing, controls red white turbid urine.”

Rhizoma Et Radix Notopterygii property is pungent, bitter in the mouth, temperature.Return bladder, kidney channel.Function cures mainly cold expelling, dispels the wind, and dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.For anemofrigid cold, headache body pain.The pungent temperature of this product, gas is male and fall apart, deliver power strong, the heresy of main loose Taiyang channel ailment said due to cold or exposure and cold-damp, have that cold expelling dispels the wind, the merit of removing dampness to relieve pain, control wind-cold damp pathogen attack table therefore kind, fever with aversion to cold, flesh table is lossless, headache stiffness of the nape, limb aching pain person, the same use of medicine such as normal and Semen Persicae, Rhizoma Et Radix Notopterygii, Radix Clematidis, Rhizoma Chuanxiong, as Notoptreygium Decoction of Nine Ingredients; If cold-damp lays particular stress on, headache body severe one, can compatibility Radix Angelicae Pubescentis, the medicine such as manuscript, Rhizoma Chuanxiong, as Decoction of Notopterygium for Rheumatism.Rhizoma Et Radix Notopterygii tanginess is to manufacture the good volatile oil of drop pill.

Herba Asari cures mainly: dispels the wind, and cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.All herbal medicine, with being antipyretic, diuresis, analgesia, tranquilizer.Control headache, the effect of have diaphoresis, eliminating the phlegm.Cold expelling dispels the wind; Pain relieving; Warming the lung to resolve fluid-retention; Sensible.Exterior syndrome due to wind-cold; Headache, toothache; Rheumatic arthralgia; Phlegm retention cough with asthma; Nasal obstruction; Nasal sinusitis; Aphtha.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.

The Radix Angelicae Dahuricae, meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.< < Japan hanako materia medica > >: control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

Pseudobulbus Bletillae (Rhizoma Bletillae) tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain, soup fire is burnt, rhagadia manus et pedis.Pseudobulbus Bletillae (Rhizoma Bletillae) rich in starch, glucose, volatile oil, phlegmatic temperament etc., external is embrocated, and the vestige under can eliminating as acne on the face, makes skin smooth seamless.Bencao Jingshu > >: Pseudobulbus Bletillae (Rhizoma Bletillae), hardship can expel the heat-evil, pungent can eliminating stagnation, carbuncle all by Ying Qi not from, contraryly in meat, give birth to; Lose the dead flesh of cellulitis impairment of YIN, due to all hot heap soil or fertilizer over and around the roots blood stasis, therefore know main also.Pathogen person in stomach, pathogenic heat are also; Harmful wind miliaria is slow not to be received, and all blood system has heat, and institute's life of damp-heat and impairment of yin type serious also, enters blood system to expel the heat-evil, and eliminating stagnation is by corruption, and all cards waste not recover.

Myrrha is the oleo-gum-resin that olive subject plant myrrh Commiphora myrrha Eng l. (Commiphora molmol Engl.) and congener trunk skin zone ooze out.The Myrrha blood blood stasis removing that falls apart, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Hardship, pungent, flat.1. < < property of medicine opinion > >: " bitter in the mouth is pungent." 2. < < Haiyao Bencao, Oversea Materia Medica > >: " bitter in the mouth is pungent, and temperature is nontoxic." 3. < < Kaibao Bencao > >: " and bitter in the mouth, flat, nontoxic." enter liver, spleen, the heart, kidney channel.1. < < Bencao Jingshu > >: " enter meridian of Foot-JUE YIN." the 2. newly organized > > of < < book on Chinese herbal medicine: " enter spleen, kidney two warps." the 3. < < book on Chinese herbal medicine > > that looks for the truth: " enter the heart, liver." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting relaxing muscles and tendons; Wear Squama Manis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Match exhausts, promoting blood circulation to remove blood stasis, pain relieving.Join Realgar, detumescence and promoting granulation, dampness removing toxic substances.

Olibanum is arduous, temperature.Regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.< < does not record > >: treat edema due to wind pathogen poison swollen, remove bad odor.Treat the urticaria poison of itching.< < Bencao Shiyi > >: treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooledly, stop large intestine and let out Bleach, treat all skin ulcers and make internal diabetes.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.< < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, pay no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls, stops metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, < < A Supplement to the Compendium of Materia Medica > > carries it and can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration is that treatment blood stasis is not loose, the good medicine that nourishing blood become silted up and invigorated blood circulation.

The present invention is externally-applied health-care products, and the preparation method of its liniment comprises:

According to described umber by raw material Fructus Anisi Stellati 1000g, Rhizoma Chuanxiong 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Angelicae Dahuricae 1000g, Flos Carthami 1000g, Caulis Spatholobi 1000g, Herba Lycopodii 1000g, Rhizoma Kaempferiae 1000g, Rhizoma Polygoni Cuspidati 1000g, Radix Saposhnikoviae 1000g, Herba Asari 1000g, Rhizoma Drynariae 1000g, Herba Erodii 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Herba speranskiae tuberculatae 1000g, Myrrha 1000g, Olibanum 1000g, Radix Dipsaci 1000g, Rhizoma Et Radix Notopterygii 1000g, Eupolyphaga Seu Steleophaga 1000g, by soak with ethanol, rear 60～85 ℃ of heat are extracted 3 times, each 1 hour; Ethanol used is 10 times of amounts of described raw material gross weight; The concentrated ethanol extract of heating, is concentrated into relative density and is 1.06 concentrated solution, stand for standby use; Medicinal residues are dropped into pulverizer and pulverize, put into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, flood 10～15 days with ethanol is common, the liquid having flooded and medicinal residues are carried out to squeeze and filter, after separation, get filtrate, then mixed with aforementioned concentrated solution; Described mixed liquid heating is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grind to form fine-powdered with Rhizoma Et Radix Notopterygii is mixed, mix vaseline and make liniment.

Unguentum preparation method of the present invention:

By raw material Fructus Anisi Stellati 1200g, Rhizoma Chuanxiong 1100g, Radix Salviae Miltiorrhizae 1300g, Radix Angelicae Dahuricae 1200g, Flos Carthami 1300g, Caulis Spatholobi 1200g, Herba Lycopodii 1300g, Rhizoma Kaempferiae 1300g, Rhizoma Polygoni Cuspidati 1200g, Radix Saposhnikoviae 1200g, Herba Asari 1200g, Rhizoma Drynariae 1300g, Herba Erodii 1100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1400g, Herba speranskiae tuberculatae 1200g, Myrrha 1200g, Olibanum 1200g, Radix Dipsaci 1200g, Rhizoma Et Radix Notopterygii 1300g, Eupolyphaga Seu Steleophaga 1200g, in Oleum Sesami, soak 7-10 days, heating extraction effective ingredient, big fire is boiled, after Oleum Sesami boiling, firepower reduces, endure to pharmaceutical presentations and be dark brown, inner coke yellow, pull medicinal residues out, medicine oil is continued to temper, and constantly stir, cigarette is by Bai Zhuanqing, refining is to dripping into pearl, Plumbum preparatium is fried to vermilion, remove moisture, cross 100 mesh sieves and remove impurity, Plumbum preparatium is slowly added in the medicine oil having refined, constantly stir, become the thick paste of black, in the slightly cold rear impouring cold water of the plaster having refined, soak 5-10 days, change water every day once, releasing fire-toxin.

The preparation method of tincture of the present invention:

According to described umber by raw material Fructus Anisi Stellati 1300g, Rhizoma Chuanxiong 1200g, Radix Salviae Miltiorrhizae 1200g, Radix Angelicae Dahuricae 1300g, Flos Carthami 1300g, Caulis Spatholobi 1200g, Herba Lycopodii 1300g, Rhizoma Kaempferiae 1300g, Rhizoma Polygoni Cuspidati 1200g, Radix Saposhnikoviae 1200g, Herba Asari 1300g, Rhizoma Drynariae 1300g, Herba Erodii 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1400g, Herba speranskiae tuberculatae 1200g, Myrrha 1200g, Olibanum 1300g, Radix Dipsaci 1200g, Rhizoma Et Radix Notopterygii 1400g, Eupolyphaga Seu Steleophaga 1300g, by proportioning, mix, put into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, flood 10～15 days with ethanol is common, the liquid having flooded and medicinal residues are carried out to squeeze and filter, after separation, get filtrate, after filtrate concentration extraction, can directly be applied in patient part.Also can be condensed into and mix vaseline after powder or Cera Flava is made liniment.Can directly be applied in patient part.Cera Flava is the wax of Apis secretion, has the function of astringent therapy, sore, granulation promoting, pain relieving, outward for ulcer being unable to heal, ecthyma erosion, wound, burn and scald etc., suppresses local organization inflammation, promotes histiocyte growth, accelerates the healing of ulcer skin.Pharmacological testing proof Cera Flava extracting solution has parallel antibacterial action to bacillus larvae, honeycomb bacillus.Cera Flava is commonly used for the substrate of excipient and the external-use ointment of Chinese patent medicine.Cera Flava is used as medicine and can regulates soft durometer as the substrate of ointment, improves release and the absorption of medicine.In Chinese medicine ointment of the present invention, Cera Flava, in performance convergence, granulation promoting pain relieving drug effect, also serves as the effect of substrate.

Pharmacology's toxicity test

1. irritation test

Get rabbit and shave hair, with externally-applied liniment of the present invention, induce and excite contact test, viewing test rabbit after 24 hours and 48 hours, all loseing skin has the phenomenons such as erythema and edema, with negative control group zero difference.Result shows, this patch is bordering on zero to dermoreaction intensity, without skin allergic reaction.

2. adopt allotransplantation in rats passive cutaneous anaphylaxis, PCA (PCA), dinitrochlorobenzene (DNCB) inducing mouse Delayed onset allergic disease model, observe the impact on allotransplantation in rats passive cutaneous anaphylaxis, PCA (PCA), mice delayed hypersensitivity (DTH) of the present invention, result shows that Chinese medicine health care product of the present invention can suppress allotransplantation in rats passive cutaneous anaphylaxis, PCA and mice delayed hypersensitivity; Chinese medicine health care product xylol induced mice auricle edema of the present invention and rat paw carrageenin is caused to swollen impact, all shows obvious antiinflammatory action; To histamine, dextran respectively due to Cavia porcellus, mouse skin is scratched where it itches also obvious inhibitory action.

3. acute toxicity test

With this product, with 300 times of clinical consumption per day, give white mouse oral administration medicine supplying, observe 5.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse damaged skin is carried out to irritation test, there are no irritative response and other untoward reaction.

Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.

4. long term toxicity test:

Health product of the present invention to mice by 7.69,19.18 and 15 weeks (1.0ml/100g body weight of 43.21g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: health product of the present invention all have no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after health product of the present invention are to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Pharmacological experiment explanation

1, conduction of heat causes mice plan pain reaction (hot plate method) experiment

One-level ICR mice, body weight 18～22g, female; RB-200 intelligence hot-plate instrument, 55 ± 0.5 ℃ of program control temperatures, the mice of take licks metapedes as induced pain index, while occurring licking metapedes, the time used is its pain threshold, measure the normal pain threshold of each Mus, 50 of the mice of the normal pain threshold in choosing pool between 5～30s, are divided into 5 groups at random, every group 10, grouping and administration situation are in Table 1.

Impact test administration and the grouping situation of table 1 on mice hot plate induced pain

Measure after normal pain threshold, each treated animal by upper table administration, is smeared, and after administration 30,60,90min (ZHENGHONGHUA YOU group be 15,60,90min) measures respectively pain threshold after each Mus administration, calculates the threshold of pain and improves percentage rate.Statistical procedures: adopt SPSS10.0 software one factor analysis of variance to add up, data result is added and subtracted standard deviation (x ± s) with mean and represented.The results are shown in Table 2

The impact of table 2 on mice hot plate induced pain

With the comparison of blank group, * * * p < 0.001; * p < 0.01; * p < 0.05.

Table 2 result shows, this product can obviously improve the pain threshold of hot plate induced pain mice, with the comparison of blank group, and senior middle school's low dose group p < 0.01 during 60min, high during 90min, middle dosage group p < 0.05.Prompting this product has obvious analgesic effect to hot plate induced pain mice.

2, xylol causes the impact of mice auricle swelling

60 of male ICR mouses, are divided into model control group, positive controls at random by body weight, the high, medium and low dosage group of the present invention, totally 5 groups, 12 every group.Senior middle school low dose group rat is smeared respectively this product 500,250,125mg/kg, and positive controls is smeared ZHENGHONGHUA YOU 121mg/kg, and model group gives equal-volume normal saline, every large 1 time, continuous 7 days, after last administration 1 hour, 50 μ l dimethylbenzene are applied to two sides before and after every mouse right ear.After 4 hours, de-neck is put to death, and cuts ears, with diameter, is that 8mm rustless steel punching pin sweeps away left and right auricle, weigh, using the difference of two auricle weight as the index of weighing swelling degree, and antiinflammatory action intensity represents with suppression ratio (%), with SPSS11.5 software kit, carries out statistical analysis.The results are shown in Table 3.

Table 3 is on the impact of mice ear (x ± s)

Group	Number of animals	Swelling (mg)
			Model control group	12	14.38±2.16
Positive controls	12	2.19±0.99***
			High dose group of the present invention	12	3.56±1.78**
Dosage group in the present invention	12	6.21±1.82*
			Low dose group of the present invention	12	10.15±2.52*

With model control group comparison: * p < 0.05, * * p < 0.01, * * * p < 0.001

Experimental result shows, this product capsule xylol causes mice auricle swelling obvious inhibitory action, and its high dose group and model group relatively have utmost point significant difference.

3, the present invention resists the observed result of mice group Ankle Joint Inflammation swelling

The observed result of table 4 medicine antagonism mice group Ankle Joint Inflammation swelling

The specific embodiment:

Embodiment 1, money, man, 22 years old, when medical readme because of by motorcycle with rear-end collision, knee joint is clashed into tailstock bumper, left knee has an intense pain, film making no abnormality seen, oral and the YUNNAN BAIYAO external application of readme ibuprofen, pain slightly alleviates, after 5 days, find knee swelling, limitation of activity, Sui Daowo section is medical, diagnosis: traumatic right gonarthromeningitis, external the present invention, side uses: Fructus Anisi Stellati 13g, Rhizoma Chuanxiong 11g, Radix Salviae Miltiorrhizae 13g, Radix Angelicae Dahuricae 12g, Flos Carthami 13g, Caulis Spatholobi 12g, Herba Lycopodii 13g, Rhizoma Kaempferiae 13g, Rhizoma Polygoni Cuspidati 12g, Radix Saposhnikoviae 11g, Herba Asari 12g, Rhizoma Drynariae 13g, Herba Erodii 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 14g, Herba speranskiae tuberculatae 12g, Myrrha 12g, Olibanum 12g, Radix Dipsaci 14g, Rhizoma Et Radix Notopterygii 12g, Eupolyphaga Seu Steleophaga 12g, make spray, spraying every day, through with curing after 1 month, freedom of movement.

Embodiment 2: go into business certain, and man, 15 years old, to like at ordinary times to play basketball, knee is sprained in the readme once process of playing basketball, and accompanies arthroncus, hydrops nearly January.Western medicine diagnose is " synovitis is accompanied a small amount of hydrops ", and pain is abnormal, handicapped.Limitation of activity, Sui Daowo section is medical, and side uses: Fructus Anisi Stellati 12g, Rhizoma Chuanxiong 11g, Radix Salviae Miltiorrhizae 13g, Radix Angelicae Dahuricae 12g, Flos Carthami 13g, Caulis Spatholobi 13g, Herba Lycopodii 13g, Rhizoma Kaempferiae 13g, Rhizoma Polygoni Cuspidati 12g, Radix Saposhnikoviae 11g, Herba Asari 12g, Rhizoma Drynariae 11g, Herba Erodii 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 14g, Herba speranskiae tuberculatae 12g, Myrrha 12g, Olibanum 12g, Radix Dipsaci 14g, Rhizoma Et Radix Notopterygii 14g, Eupolyphaga Seu Steleophaga 13g, makes unguentum, smears affected part every day.Adopt above-mentioned treatment 2 weeks, 5 days is a course for the treatment of, and the gonalgia disappears substantially, and swelling disappears, freedom of movement.

Embodiment 3: land, man, 28 years old.First visit.Main suit: unable 7 years of right knee joint Zhong Zhang Bright-eyed pain, increases the weight of more than 2 years.Right knee joint Zhong Zhang Bright-eyed pain 7 years, has advance and retreat when swelling and ache, and over nearly 2 years, swells and ache and continues not subtract, movable when more pain increase the weight of, have trauma history.Chinese and western medicine multi-treatment once, it is all invalid that successively tapping reaches more than 10 times (weak yellow liquids).Check: the swelling of right knee joint height, color of the leather is shinny, and groove disappears, and that touches fullly has a fluctuation, and tenderness is obvious, and floating patella test is positive, atrophy of quadriceps femoris.X-ray film shows osteoarthrosis gap broadening (comprising patellofemoral joint), and sclerotin destroys without hypertrophy.Diagnosis: right traumatic synovitis of knee joint (chronic).External the present invention, side uses: Fructus Anisi Stellati 11g, Rhizoma Chuanxiong 11g, Radix Salviae Miltiorrhizae 13g, Radix Angelicae Dahuricae 12g, Flos Carthami 13g, Caulis Spatholobi 12g, Herba Lycopodii 12g, Rhizoma Kaempferiae 13g, Rhizoma Polygoni Cuspidati 14g, Radix Saposhnikoviae 11g, Herba Asari 12g, Rhizoma Drynariae 13g, Herba Erodii 11g, Pseudobulbus Bletillae (Rhizoma Bletillae) 14g, Herba speranskiae tuberculatae 12g, Myrrha 12g, Olibanum 12g, Radix Dipsaci 14g, Rhizoma Et Radix Notopterygii 12g, Eupolyphaga Seu Steleophaga 13g.Make patch.Advise and take in sail.Two examine, and swelling is displaced downwardly to hypomere in shank, and knee swelling is gone down.Three examine, and suffering limb swelling is obviously disappeared, and floating patella test is not obvious, and tenderness is very micro-.Enter again 7 doses.Check, swelling, tenderness disappear completely, and intraarticular hydrops absorbs, and recovers normal activity.Only quadriceps femoris moderate atrophy, advises it to strengthen taking exercise.

Claims (9)

1. alleviate bones and muscles pain for one kind, the Chinese medicine health care product of arthralgia, it is characterized in that, in described Chinese medicine health care product, the parts by weight of various raw materials are: 10～20 parts of Fructus Anisi Stellatis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Lycopodiis, 10～20 parts of Rhizoma Kaempferiae, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Asaris, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Herba Erodiis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Herba speranskiae tuberculataes, 10～20 parts of Myrrhas, 10～20 parts of Olibanums, 10～20 parts of Radix Dipsacis, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Eupolyphaga Seu Steleophagas.

2. alleviate according to claim 1 bones and muscles pain, the Chinese medicine health care product of arthralgia, it is characterized in that, in described Chinese medicine health care product, the parts by weight of various raw materials are: 10～15 parts of Fructus Anisi Stellatis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts, Flos Carthami, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Lycopodiis, 10～15 parts of Rhizoma Kaempferiae, 10～15 parts of Rhizoma Polygoni Cuspidati, 10～15 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Asaris, 10～20 parts of Rhizoma Drynariae, 10～20 parts of Herba Erodiis, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Herba speranskiae tuberculataes, 10～20 parts of Myrrhas, 10～20 parts of Olibanums, 10～20 parts of Radix Dipsacis, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Eupolyphaga Seu Steleophagas.

3. alleviate according to claim 1 bones and muscles pain, the Chinese medicine health care product of arthralgia, it is characterized in that, in described Chinese medicine health care product, the parts by weight of various raw materials are: 10～20 parts of Fructus Anisi Stellatis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Lycopodiis, 10～20 parts of Rhizoma Kaempferiae, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Herba Asaris, 10～15 parts of Rhizoma Drynariae, 10～15 parts of Herba Erodiis, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Herba speranskiae tuberculataes, 10～15 parts of Myrrhas, 10～15 parts of Olibanums, 10～15 parts of Radix Dipsacis, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Eupolyphaga Seu Steleophagas.

4. according to the Chinese medicine health care product of alleviating bones and muscles pain, arthralgia described in any one in claim 1～3, it is characterized in that, the dosage form of described health product is: liniment, ointment, plaster, cream, spray or patch.

5. as described in any one in claim 1～3, alleviate a preparation method for the Chinese medicine health care product of bones and muscles pain, arthralgia, it is characterized in that, the dosage form of described health product is unguentum, and its preparation method comprises:

A. the crude drug of getting above-mentioned parts by weight is put into Oleum Sesami and is soaked;

B. more soaked crude drug is heated and tempered in Oleum Sesami;

C. medicine oil is put into in the Plumbum preparatium of having fried and stir into paste;

D. the ointment having refined is put into releasing fire-toxin in cold water.

6. alleviate according to claim 6 the preparation method of the Chinese medicine health care product of bones and muscles pain, arthralgia, it is characterized in that, in described step a, by the crude drug of described parts by weight, add in the Oleum Sesami of 5-10 times of weight portion and soak 7-10 days.

7. alleviate according to claim 6 the preparation method of the Chinese medicine health care product of bones and muscles pain, arthralgia, it is characterized in that, in described step b, by the soaked crude drug heating extraction of Oleum Sesami, big fire is boiled, after Oleum Sesami boiling, firepower reduces, and endures to crude drug appearance and is dark brown, inner coke yellow, pull medicinal residues out, medicine oil is continued to temper, and constantly stir, refining is to dripping into pearl.

8. alleviate according to claim 6 the preparation method of the Chinese medicine health care product of bones and muscles pain, arthralgia, it is characterized in that, in described step c, Plumbum preparatium is fried to dark yellow, remove moisture, cross 100 mesh sieves and remove impurity; Plumbum preparatium is added in the medicine oil having refined, constantly stir, become the thick paste of black.

9. alleviate according to claim 6 the preparation method of the Chinese medicine health care product of bones and muscles pain, arthralgia, it is characterized in that, in described steps d, in the slightly cold rear impouring cold water of black thick paste having refined, soak 5-10 days, change water every day once, releasing fire-toxin.