CN103083372A - Application of freeze-dried purslane in preparation of medicine for treating hemorrhoids - Google Patents
Application of freeze-dried purslane in preparation of medicine for treating hemorrhoids Download PDFInfo
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- CN103083372A CN103083372A CN2013100083654A CN201310008365A CN103083372A CN 103083372 A CN103083372 A CN 103083372A CN 2013100083654 A CN2013100083654 A CN 2013100083654A CN 201310008365 A CN201310008365 A CN 201310008365A CN 103083372 A CN103083372 A CN 103083372A
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- herba portulacae
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- lyophilizing herba
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Abstract
The invention provides application of freeze-dried purslane in preparation of a medicine for treating hemorrhoids. The application is characterized in that the medicine contains freeze-dried purslane, and when the freeze-dried purslane is used for preparing the medicine, the technical problems that the fresh purslane is short in preservation time, the transport cost is extremely high and the active ingredients are high in loss and the like are solved, and the medicine has a good treating effect on hemorrhoids.
Description
Technical field
The present invention relates to medicine, the particularly application of a kind of lyophilizing Herba Portulacae in the preparation medicine belongs to medical technical field.
Background technology
Herba Portulacae (Portulaca oleracea L.) is the annual meat herbaceous plant of Portulacaceae (Portulacease) Portulaca (Portulaca).Another name is the female dish of horse Herba Amaranthi tricoloris, five elements' grass, rope made of hemp dish, HERBA PORTULACAE, horse three-coloured amaranth, locust dish, Dens Equi dish, melon rice dish, horse Serpentis dish, Formica fusca dish, pig, Pericarpium Lagenariae hispidae dish, lion high mountain dish, sauerkraut, five elements' dish, pig fertilizer dish etc.Herba Portulacae is conventional Chinese medicine, is used as medicine mainly with its dry aerial parts, and nature and flavor acid, cold has the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving, is used for that toxic-heat and blood stasis, carbuncle are treated skin ulcer, eczema, erysipelas, snake bite and insect sting, had blood in stool, hemorrhoidal bleeding and metrostaxis.Dens Equi is looked for and is contained the number of chemical composition, is mainly organic acid, flavonoid, mushrooms, Coumarins, alkaloids, volatile oil and polysaccharide etc.; Modern pharmacological research shows that Dens Equi grassland and active component thereof have the effects such as antibiotic, antiviral, antitumor, accent blood fat, blood sugar lowering, defying age, atherosclerosis.Modern nutriology research discovery, the Dens Equi grassland has stronger bactericidal antiphlogistic effect, can be used for the auxiliary treatment of inflammation, together lists the row of " natural antibiotic " in Bulbus Allii.2009, after Ministry of Public Health and the State Administration of Traditional Chinese Medicines recommend the overgrown with weeds 30-60g of bright Dens Equi to mourn with boiled water in " influenza A H1N1 Chinese medicine prevention scheme ", with the cold and dressed with sauce food of Bulbus Allii juice vinegar with the prevention swine flu.
We find, the lyophilizing Herba Portulacae shows better curative effect than the Herba Portulacae that tradition is dried in many tests, and particularly preparation treatment hemorrhoid show better curative effect.
Summary of the invention
The invention provides the application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie.
The application of lyophilizing Herba Portulacae of the present invention in the preparation medicine for treaching hemorrhoie, feature is that described medicine contains the lyophilizing Herba Portulacae.
The application of lyophilizing Herba Portulacae of the present invention in the preparation medicine for treaching hemorrhoie, feature is that described medicine is prepared by single flavor lyophilizing Herba Portulacae.
The application of lyophilizing Herba Portulacae of the present invention in the preparation medicine for treaching hemorrhoie, feature is that described medicine contains the lyophilizing Herba portulacae extract.
The application of lyophilizing Herba Portulacae of the present invention in the preparation medicine for treaching hemorrhoie, feature is that described medicine is prepared by single lyophilizing Herba portulacae extract.
The application of lyophilizing Herba Portulacae of the present invention in the preparation medicine for treaching hemorrhoie, feature is that the lyophilizing Herba Portulacae is directly pulverized, and makes external preparation.
The application of lyophilizing Herba Portulacae of the present invention in the preparation medicine, feature are according to actual needs, further to add other raw material of Chinese medicine preparations.
The application of lyophilizing Herba Portulacae of the present invention in the preparation medicine for treaching hemorrhoie, feature is to make external preparation.
The lyophilizing Herba Portulacae has solved short, the technical problem such as freight is too high, loss of effective components is larger of fresh Herba Portulacae holding time.Also do not treat at present the report of hemorrhoid with the preparation of lyophilizing Herba Portulacae.Below by test example explanation usefulness of the present invention.
Herba Portulacae has multiple biological activity, and the polysaccharide in Herba Portulacae is main composition, and the effect of anti-inflammation, pain relieving, enhancing immunity, promotion cell migration is arranged.Noradrenalin in Herba Portulacae can make blood stasis shrink rapidly, thereby can alleviate rapidly the misery of hemorrhoid patients.Below dried Polysaccharide from Portulaca oleracea, the noradrenalin content of the more common drying of test explanation lyophilizing Herba Portulacae obviously improve, and then infer that its curative effect is better than the dried Herba Portulacae of common drying.
1, the dried Herba Portulacae of preparation and lyophilizing Herba Portulacae
Get fresh Herba Portulacae and wash, drain the water.1. with the Herba Portulacae sabot that drains away the water, thickness is 15～20 mm, puts constant temperature oven, and is dry below 80 ℃, gets dried Herba Portulacae; 2. with the Herba Portulacae sabot that drains away the water, thickness is 15～20 mm, in freezing process, controls cooling rate, and with 0.3～0.5 ℃/min, solidification point is controlled between-28～-32 ℃; The vacuum degree control of sublimation stage is at 60pa, and desorption phase vacuum will slightly increase, and is controlled at 40 pa; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Herba Portulacae.
2, determination of polysaccharide
take respectively dried Herba Portulacae and lyophilizing Herba Portulacae powder 10 g, put in apparatus,Soxhlet's, add petroleum ether (boiling range is 60～90 ℃) 150 mL, 90 ℃ of reflux, extract, 2 h defats, sucking filtration, after filtering residue volatilizes solvent, add 80% ethanol 150 mL, 95 ℃ of water-baths backflow 2 h, double-layer filter cloth filters, filtering residue adds the 400mL distilled water, 90 ℃ of reflux, extract, 1h, double-layer filter cloth filters, filtering residue adds the 200mL distilled water, 90 ℃ of reflux, extract, 2 times, each 1h, filter, merge 3 times filtrate, centrifugalize (5000 r/min, 10min), the Sevage method is except albumen, repeatedly carry out 3 times extremely without albumin layer, then with the tap water dialysis 48h that flows, distilled water
Dialysis 24h, the dialysis solution vacuum concentration is to 50mL, add dehydrated alcohol to make concentration of alcohol reach 80% in concentrated solution, precipitate with ethanol spends the night in 4 ℃ of refrigerators, dehydrated alcohol, acetone, ether washed twice are used in centrifugalize again, precipitate successively, (60 ℃ of vacuum dryings, 0.095 MPa) to constant weight, namely get total polysaccharides.
3, noradrenalin assay
Take respectively dried Herba Portulacae and lyophilizing Herba Portulacae powder 10 g, add petroleum ether (boiling range is 60～90 ℃) 150 mL, merceration 24h defat, sucking filtration, after filtering residue vacuum (room temperature, 0.095 MPa) volatilizes solvent, add 100mL0.1mol/L HCl solution, wrap up supersound extraction 1.5h after sealing with black plastic film.Uses the filter paper coarse filtration after extracting, and be stored in brown container with the sun-proof oxidation, be placed in 4 ℃ of refrigerators and save backup.Adopt Micellar Electrokinetic Chromatography Amperometric Detection Coupled Noradrenaline Contents.
4, two composition content results of laboratory test see the following form.
| ? | Norepinephrine (%) | Polyoses content (%) |
| Dried Herba Portulacae | 0.01 | 8.62 |
| The lyophilizing Herba Portulacae | 0.19 | 17.26 |
The specific embodiment
The application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie.
The application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie, feature is that described medicine contains the lyophilizing Herba Portulacae.
The application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie, feature is that described medicine is prepared by single flavor lyophilizing Herba Portulacae.
The application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie, feature is that described medicine contains the lyophilizing Herba portulacae extract.
The application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie, feature is that described medicine is prepared by single lyophilizing Herba portulacae extract.
The application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie, feature is that the lyophilizing Herba Portulacae is directly pulverized, and makes external preparation.
The application of lyophilizing Herba Portulacae in the preparation medicine, feature are according to actual needs, further to add other raw material of Chinese medicine preparations.
The application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie, feature is to make the external preparation such as washing liquid, ointment, gel, suppository.
Embodiment 1
To clean the Herba Portulacae sabot of roguing, thickness is 15～20 mm, and in freezing process, with 0.3 ℃/min cooling, solidification point is controlled at-32 ℃; The vacuum degree control of sublimation stage is at 60pa, desorption phase vacuum 50 pa; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Herba Portulacae.
Get the lyophilizing Herba Portulacae, pulverize, cross 120 mesh sieves, mix well with Oleum Sesami, get ointment, the treatment hemorrhoid are embrocated in the affected part pain relieving in 1 minute.
Embodiment 2
Get the lyophilizing Herba Portulacae, extracting in water 2 times, concentrated, add carbomer and make gel, be used for the treatment of hemorrhoid, to embrocate in the affected part every day 2 times, pain relieving in 1 minute was cured in 3 days.
Embodiment 3
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose new fresh Herba Portulacae, clean roguing, sabot, sabot weight is 7kg/ ㎡ left and right, carries out pre-freeze to-28 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to the absolute pressure 60Pa of system, begin to be heated to 35 ℃, sublimation drying 15 hours; Keep again 40 ℃ of temperature of charge, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Herba Portulacae.
Get lyophilizing Herba Portulacae 50kg, Cortex Phellodendri 25Kg, ethanol percolate extraction, decompression recycling ethanol adds water and makes 1000 bottles of washing liquids, the treatment hemorrhoid, each 1 bottle, add warm water, wash the affected part, every day 2 times, cured in 3 days.
Embodiment 4
Get freeze dried fresh Herba Portulacae 30kg, use ethanol percolate extraction, extracting solution reclaims ethanol, and drying gets the lyophilizing Herba portulacae extract.Make suppository with polyethylene glycol mono stearate, the treatment hemorrhoid, every day is each 1 (being equivalent to lyophilizing Herba Portulacae 15g) sooner or later, and pain relieving in 1 minute was cured in 3 days.
Embodiment 5
Get the lyophilizing Herba Portulacae, 80% ethanol percolate extraction, decompression recycling ethanol gets lyophilizing Herba Portulacae extractum.
Get by weight 4.8 parts of stearic acid, 1.4 parts of glyceryl monostearates, 2.4 parts of liquid Paraffin, 0.4 part of white vaseline, 2.0 parts of lanolines, 0.16 part of triethanolamine, 5 parts of lyophilizing Herba Portulacae extractum, distilled water and add to 40.0 parts; Method for making stearic acid, glyceryl monostearate, liquid Paraffin, white vaseline and lanoline are oil phase, put in container, are heated to 80 ℃ of left and right mixed meltings in water-bath.Separately with lyophilizing Herba Portulacae extractum, triethanolamine and distilled water mixing, also be heated to 80 ℃ of left and right in water-bath.Slowly pour water into oil phase under isothermal in, and constantly be stirred to the semi-solid that is creamy white in water-bath, more at room temperature be stirred to nearly condensation, get emulsifiable paste.
Claims (8)
1. the application of lyophilizing Herba Portulacae in the preparation medicine for treaching hemorrhoie.
2. according to claim 1 lyophilizing Herba Portulacae is in the application of preparation in medicine for treaching hemorrhoie, and feature is that described medicine contains the lyophilizing Herba Portulacae.
According to claim 1 or the lyophilizing Herba Portulacae of claim 2 in the application of preparation in medicine for treaching hemorrhoie, feature is that described medicine is prepared by single flavor lyophilizing Herba Portulacae.
4. according to claim 1 lyophilizing Herba Portulacae is in the application of preparation in medicine for treaching hemorrhoie, and feature is that described medicine contains the lyophilizing Herba portulacae extract.
5. according to claim 1 lyophilizing Herba Portulacae is in the application of preparation in medicine for treaching hemorrhoie, and feature is that described medicine is prepared by single lyophilizing Herba portulacae extract.
6. according to claim 1 lyophilizing Herba Portulacae is in the application of preparation in medicine for treaching hemorrhoie, and feature is that the lyophilizing Herba Portulacae is directly pulverized, and makes external preparation.
According to claim 1 or the lyophilizing Herba Portulacae of claim 2 or claim 4 in the application of preparation in medicine for treaching hemorrhoie, feature is according to actual needs, further to add other raw material of Chinese medicine preparations.
According to claim 1 or the lyophilizing Herba Portulacae of claim 2 or claim 3 or claim 4 or claim 5 or claim 6 or claim 7 in the application of preparation in medicine for treaching hemorrhoie, the application of lyophilizing Herba Portulacae of the present invention in the preparation medicine for treaching hemorrhoie, feature is external preparation processed.
Priority Applications (1)
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| CN2013100083654A CN103083372A (en) | 2013-01-10 | 2013-01-10 | Application of freeze-dried purslane in preparation of medicine for treating hemorrhoids |
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Cited By (2)
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| CN103784569A (en) * | 2014-02-17 | 2014-05-14 | 大连圣弘医药有限公司 | Traditional Chinese medicine for treating hemorrhoid and preparation method thereof |
| CN104623083A (en) * | 2015-02-06 | 2015-05-20 | 张华� | Cleaning suppository for treating haemorrhoids |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784569A (en) * | 2014-02-17 | 2014-05-14 | 大连圣弘医药有限公司 | Traditional Chinese medicine for treating hemorrhoid and preparation method thereof |
| CN103784569B (en) * | 2014-02-17 | 2016-03-23 | 大连圣弘医药有限公司 | A kind ofly treat Chinese medicine of hemorrhoid disease and preparation method thereof |
| CN104623083A (en) * | 2015-02-06 | 2015-05-20 | 张华� | Cleaning suppository for treating haemorrhoids |
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Application publication date: 20130508 |