CN103083346A - Broad-spectrum anti-parasitic compound doramectin transdermal solution for pets - Google Patents
Broad-spectrum anti-parasitic compound doramectin transdermal solution for pets Download PDFInfo
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- CN103083346A CN103083346A CN 201110342884 CN201110342884A CN103083346A CN 103083346 A CN103083346 A CN 103083346A CN 201110342884 CN201110342884 CN 201110342884 CN 201110342884 A CN201110342884 A CN 201110342884A CN 103083346 A CN103083346 A CN 103083346A
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Abstract
The invention relates to a broad-spectrum anti-parasitic compound doramectin transdermal solution for pets and its preparation method. The solution is composed of the following components by mass: 0.5%-1% of doramectin, 0.5%-1% of fenbendazole, 40%-70% of propylene glycol, 15%-30% of isopropyl alcohol, 10%-20% of polyethylene glycol 400, 1%-5% of glycerol, and 2% -5% of azone. The solution is prepared by subjecting the main drugs to dissolution, mixing, filtering and filling. Compared with traditional anti-parasitic drugs, broad spectrum, the broad-spectrum and high efficiency anti-parasitic transdermal solution provided in the invention can increase absorption of drugs by the skin, avoids a hepatic first-pass effect, and can directly reach a target site, thus achieving better clinical effects.
Description
Technical field
The present invention relates to a kind of house pet compound recipe doractin transdermal solution of broad-spectrum anti-parasite disease.Belong to field of veterinary.
Background technology
Along with improving constantly of people's living standard, in many cities, pet craze appears.Bring enjoyment can for although keep a pet flat life, also can be used as a kind of lonely and mental pressure of alleviating people of entrusting to the care of of emotion.But people have increased the chance that contacts with house pet in the process of funny house pet of raising, play, also increased the probability that infects the Zoonosis parasitic disease.Parasite can be propagated various diseases, causes the unhealthy of house pet and owner, can cause death of pet when serious, especially the house pet of hypoimmunity.
Doractin is the anti-parasite medicine of New-type wide-spectrum, efficient, low toxicity, and particularly nematicide and arthropod all have the good effect of killing to endoparasite.Fenbendazole is the novel benzimidazoles anthelmintic, it not only has the height anthelmintic activity to animal intestines and stomach nematicide adult, larva, and net is belonged to nematicide, fasciola lanceolata, fasciola and cestode better effect is also arranged, both are compound has collaborative wide spectrum anthelmintic insecticidal action.
House pet anti-parasite medicine used mostly is tablet and injection at present, preparation capable of permeating skin is a kind of new form of administration, this dosage form has been avoided first pass effect of hepar and medicine and the gastrointestinal interaction of medicine, and can produce constant controlled blood drug level, reduces the toxic and side effects of medicine; Therefore in order to enrich the house pet clinical application, developed the transdermal solution of the parasiticide disease of new wide spectrum.
Summary of the invention
Based on above-mentioned situation, the purpose of this invention is to provide the compound recipe doractin transdermal solution that a kind of house pet is used the broad-spectrum anti-parasite disease.
An object of the present invention is to provide a kind of house pet compound recipe doractin transdermal solution of broad-spectrum anti-parasite disease.
Another object of the present invention is to provide a kind of preparation method of described compound recipe doractin transdermal solution.
A kind of house pet compound recipe doractin transdermal solution of broad-spectrum anti-parasite, it is characterized in that, consisting of component and weight mass fraction thereof is respectively: doractin 0.5%-1%, Phenbendasol 0.5%-1%, propylene glycol 40%-70%, dimethyl sulfoxide 10%-20%, isopropyl alcohol 15%-30%, PEG400 10%-20%, glycerol 1%-5%, azone 2%-5%.
A kind of house pet preparation method of the compound recipe doractin transdermal solution of broad-spectrum anti-parasite is characterized in that the step of preparation is: the doractin of getting recipe quantity dissolves with a small amount of propylene glycol, makes solution A; Get the Phenbendasol of recipe quantity with the dmso solution of recipe quantity, make solution B; A solution is mixed with B solution, add isopropyl alcohol, PEG400, glycerol, the azone of recipe quantity, stir, use the propylene glycol standardize solution; With the solution filtering with microporous membrane that obtains, the qualified rear fill of clarity namely gets compound recipe doractin transdermal solution.
Described microporous filter membrane is 1-5 μ m.
Skin forms most drug and is difficult to together the barrier that permeates, and transdermal is more difficult.Azone is a kind of Percutaneous absorption enhancer preferably of generally acknowledging at present, and mainly the horny layer lipoid flows and the lipoid of dissolving skin increases Drug Percutaneous Absorption by accelerating for it, is widely used in external preparation research.The present invention uses azone and dimethyl sulfoxide transdermal amount can reach more than 90% in 12h.Technique of the present invention is simple, and drug effect is remarkable, has made up the blank on house pet medicine market.
The specific embodiment
Embodiment 1:
A kind of house pet is respectively (carrying out proportioning by every 100g raw material) with the compound recipe doractin transdermal solution of broad-spectrum anti-parasite, formation component and weight mass fraction thereof:
Doractin 1 g
Phenbendasol 0.5 g
Propylene glycol 50 g
Dimethyl sulfoxide 13.5 g
Isopropyl alcohol 15 g
PEG400 10 g
Glycerol 5 g
Azone 5 g
Preparation method: the doractin of getting recipe quantity dissolves with a small amount of propylene glycol, makes solution A; Get the Phenbendasol of recipe quantity with the dmso solution of recipe quantity, make solution B; A solution is mixed with B solution, add isopropyl alcohol, PEG400, glycerol, the azone of recipe quantity, stir, be settled to 100ml with propylene glycol; With 2 μ m filtering with microporous membranes, the qualified rear fill of clarity namely gets compound recipe doractin transdermal solution with the solution that obtains.
Claims (3)
1. a house pet is with the compound recipe doractin transdermal solution of broad-spectrum anti-parasite, it is characterized in that, consisting of component and weight mass fraction thereof is respectively: doractin 0.5%-1%, Phenbendasol 0.5%-1%, propylene glycol 40%-70%, dimethyl sulfoxide 10%-20%, isopropyl alcohol 15%-30%, PEG400 10%-20%, glycerol 1%-5%, azone 2%-5%.
2. a kind of house pet described according to claims 1 with the preparation method of the compound recipe doractin transdermal solution of broad-spectrum anti-parasite, is characterized in that, the step of preparation is: the doractin of getting recipe quantity dissolves with a small amount of propylene glycol, makes solution A; Get the Phenbendasol of recipe quantity with the dmso solution of recipe quantity, make solution B; A solution is mixed with B solution, add isopropyl alcohol, PEG400, glycerol, the azone of recipe quantity, stir, use the propylene glycol standardize solution; With the solution filtering with microporous membrane that obtains, the qualified rear fill of clarity namely gets compound recipe doractin transdermal solution.
3. a kind of house pet described according to claims 2 is with the preparation method of the compound recipe doractin transdermal solution of broad-spectrum anti-parasite, and it is characterized in that: described microporous filter membrane is 1-5 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110342884 CN103083346A (en) | 2011-11-03 | 2011-11-03 | Broad-spectrum anti-parasitic compound doramectin transdermal solution for pets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110342884 CN103083346A (en) | 2011-11-03 | 2011-11-03 | Broad-spectrum anti-parasitic compound doramectin transdermal solution for pets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103083346A true CN103083346A (en) | 2013-05-08 |
Family
ID=48196827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110342884 Pending CN103083346A (en) | 2011-11-03 | 2011-11-03 | Broad-spectrum anti-parasitic compound doramectin transdermal solution for pets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103083346A (en) |
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2011
- 2011-11-03 CN CN 201110342884 patent/CN103083346A/en active Pending
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130508 |