CN103083021B - Obtaining method and device and medical equipment of optimum m1 value - Google Patents

Obtaining method and device and medical equipment of optimum m1 value Download PDF

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Publication number
CN103083021B
CN103083021B CN201210584523.6A CN201210584523A CN103083021B CN 103083021 B CN103083021 B CN 103083021B CN 201210584523 A CN201210584523 A CN 201210584523A CN 103083021 B CN103083021 B CN 103083021B
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value
target vessel
sequence
image
vessel image
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CN103083021A (en
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刘新
樊昭阳
张娜
陈汉威
钟耀祖
郑海荣
李德彪
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Abstract

The invention is applied to the technical field of medical imaging and provides an obtaining method, a device and medical equipment of an optimum m1 value. The method includes generating an m1 sequence, and the m1 sequence is composed of multiple m1 values. Two-dimension imaging on a target vessel is conducted respectively by m1=0 and each m1 value in the m1 sequence. According to image data of a two-dimension imaging result, the optimum m1 value is actually confirmed. Due to the fact that the two-dimension imaging on the target vessel is conducted only by the m1 values and the actual optimum m1 value is confirmed, the method greatly reduces calculated amount, can achieve simple and quick confirmation of the optimum m1 value, ensures obtaining of a high-quality artery image in different patient or parts, reduces misdiagnosis rate, and ensures that a non-enhanced magnetic resonance angiography (MRA) based on a female sexual arousal disorder (FSD) module becomes a vessel imaging manner for clinical use.

Description

A kind of acquisition methods of best m1 value, device and armarium
Technical field
The invention belongs to medical imaging technology field, particularly relate to a kind of acquisition methods of best m1 value, device and armarium.
Background technology
Angiography based on the loose phase preparation module (flow-sensitive dephasing, FSD) of blood flow sensitivity is that a non-radiography of peripheral arterial with potential applicability in clinical practice strengthens magnetic resonance vascular screening methods.This technology utilizes the blood flow velocity difference of artery and vein and FSD module to the sensitivity of blood flow, gathers not use " the bright arterial blood " of FSD module to gather with another to do to subtract shadow and obtain final arteries image by one being used " the black arterial blood " of FSD module.A remarkable characteristic of this technology is, the rejection ability of FSD module to blood flow signal depends on magnetic field gradient first moment (first-order gradient moment, m1) and blood flow rate.For certain specific blood flow patterns, if m1 value is chosen too small, the problem due to the arterial lumen signal deletion on the subtraction image that artery blood flow signal suppressing not exclusively causes may be there is, if and m1 value is chosen excessive, the problem owing to the suppressed subtraction image caused of vein and soft-tissue signal occurring vein pollution and soft tissue artifact may be there is.Therefore, in order to obtain satisfied magnetic resonance blood-vessel image, need, for each individuality finds out a suitable m1 value, while at utmost suppressing artery blood flow signal, to retain venous blood flow signal most.
It is consuming time to find out suitable this Measures compare of m1 value that prior art uses multiple different m1 value to carry out multiple scanning usually, is particularly unpractical for 3D imaging.
To sum up, the procedure that prior art obtains best m1 value is complicated, and consuming time longer.
Summary of the invention
The object of the embodiment of the present invention is the acquisition methods providing a kind of best m1 value, is intended to solve the procedure complexity that prior art obtains best m1 value, and longer problem consuming time.
To achieve these goals, the embodiment of the present invention provides following technical scheme:
The embodiment of the present invention is achieved in that a kind of acquisition methods of best m1 value, and described method comprises:
Generate m1 sequence, described m1 sequence comprises multiple m1 value;
With each m1 value in m1=0 and described m1 sequence, two-dimensional imaging is carried out to target vessel respectively;
According to the view data of two-dimensional imaging result, determine actual best m1 value.
The embodiment of the present invention additionally provides a kind of acquisition device of best m1 value, and described device comprises:
M1 sequence generating unit, for generating m1 sequence, described m1 sequence comprises multiple m1 value;
Two-dimensional imaging unit, for carrying out two-dimensional imaging with each m1 value in m1=0 and described m1 sequence to target vessel respectively;
M1 value determining unit, for the view data according to two-dimensional imaging result, determines actual best m1 value.
The embodiment of the present invention additionally provides a kind of armarium, and described armarium comprises the acquisition device of above-mentioned best m1 value.
The embodiment of the present invention compared with prior art, beneficial effect is: by obtaining m1 sequence, with each m1 value in m1=0 and described m1 sequence, two-dimensional imaging is carried out to target vessel respectively, according to the view data of described two-dimensional imaging result, determine actual best m1 value.Owing to only carrying out two-dimensional imaging with m1 value to target vessel, determine actual best m1 value, therefore amount of calculation is greatly reduced, realization can determine optimized individual m1 value simply, fast, guarantee all can obtain high-quality arterial images different patient or position, thus reduction misdiagnosis rate, ensure the blood vessel imaging means becoming a clinical practice based on the non-reinforcing MRA of FSD module.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme of the embodiment of the present invention, below the accompanying drawing used required in describing embodiment is briefly described, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the flow chart of the realization of the acquisition methods of the best m1 value that the embodiment of the present invention one provides;
Fig. 2 is the flow chart of the realization of the acquisition methods of the best m1 value that the embodiment of the present invention two provides;
Fig. 3 is the schematic diagram of the FSD preparation module that the embodiment of the present invention two provides;
Fig. 4 is the schematic diagram of the target vessel image acquisition process that the embodiment of the present invention two provides;
Fig. 5 a is the schematic diagram of the bright arterial images of the use experience m1 value collection that the embodiment of the present invention two provides;
Fig. 5 b is the schematic diagram of the bright arterial images of the best m1 value collection of use that the embodiment of the present invention two provides;
Fig. 6 is the structure chart of the acquisition device of the best m1 value that the embodiment of the present invention three provides;
Fig. 7 is the structure chart of the acquisition device of the best m1 value that the embodiment of the present invention four provides.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiments provide a kind of acquisition methods of best m1 value, described method comprises:
Generate m1 sequence, described m1 sequence comprises multiple m1 value;
With each m1 value in m1=0 and described m1 sequence, two-dimensional imaging is carried out to target vessel respectively;
According to the view data of two-dimensional imaging result, determine actual best m1 value.
The embodiment of the present invention additionally provides a kind of acquisition device of best m1 value, and described device comprises:
M1 sequence generating unit, for generating m1 sequence, described m1 sequence comprises multiple m1 value;
Two-dimensional imaging unit, for carrying out two-dimensional imaging with each m1 value in m1=0 and described m1 sequence to target vessel respectively;
M1 value determining unit, for the view data according to two-dimensional imaging result, determines actual best m1 value.
The embodiment of the present invention additionally provides a kind of armarium, and described armarium comprises the acquisition device of above-mentioned best m1 value.
Below in conjunction with specific embodiment, realization of the present invention is described in detail:
embodiment one
Fig. 1 shows the flow chart of the realization of the acquisition methods of the best m1 value that the embodiment of the present invention one provides, and details are as follows:
In S101, generate m1 sequence, described m1 sequence comprises multiple m1 value;
In S102, with each m1 value in m1=0 and described m1 sequence, two-dimensional imaging is carried out to target vessel respectively;
In S103, according to the view data of two-dimensional imaging result, determine actual best m1 value.
In the present embodiment, by obtaining m1 sequence, with each m1 value in m1=0 and described m1 sequence, two-dimensional imaging being carried out to target vessel respectively, according to the view data of described two-dimensional imaging result, determining actual best m1 value.Owing to only carrying out two-dimensional imaging with m1 value to target vessel, determine actual best m1 value, therefore amount of calculation is greatly reduced, realization can determine optimized individual m1 value simply, fast, guarantee all can obtain high-quality arterial images different patient or position, thus reduction misdiagnosis rate, ensure the blood vessel imaging means becoming a clinical practice based on the non-reinforcing MRA of FSD module.
embodiment two
Fig. 2 shows the flow chart of the realization of the acquisition methods of the best m1 value that the embodiment of the present invention two is confessed, and details are as follows:
In S201, emulation obtains the best m1 value of theory of current blood flow patterns;
In the present embodiment, set up a Numerical Simulation Program, the corresponding relation between the Two dimensional Distribution of cross sectional flow rate in single voxel and best m1 value is calculated by described Numerical Simulation Program, thus determine the position at theoretical best m1 value place, it is smaller that numerical value due to the best m1 value of theory best m1 value and reality differs scope, by pre-determining theoretical best m1 value, the scope at actual best m1 value place can be determined, and then improve the efficiency obtaining actual best m1 value.
In S202, take predetermined interval as ladder, in the multiple m1 value of each sampling in described theory best m1 value left and right, according to the m1 value that the best m1 value of described theory and sampling obtain, generate m1 sequence.
In the present embodiment, centered by the best m1 value emulating the current blood flow patterns obtained, about 5 values are respectively got for about ladder with 5 or 10,10 of described m1 and sampling are worth and generate m1 sequence, certainly, in actual samples process, the number of sampling interval and sampled point can be arranged according to actual needs, at this not in order to limit the present invention.
In S203, with each m1 value in m1=0 and described m1 sequence, two-dimensional imaging is carried out to target vessel respectively;
In the present embodiment, each m1 value carries out two-dimensional imaging to target vessel, and image taking speed is fast, improves the speed obtaining actual best m1.
In S204, gather the target vessel image of m1=0 and the target vessel image of described each m1 value correspondence;
In the present embodiment, when m1 equals 0, the target vessel image of collection comprises bright arterial blood image and bright venous blood image; When m1 is not equal to 0, along with the continuous increase of m1 value, the arterial blood image in the target vessel image of collection is suppressed to black arterial blood image gradually, and venous blood image is then influenced smaller.
In the present embodiment, specifically can by two-dimension balance steady state free precession (the FSD-prepared balanced steady-state free precession of FSD preparation module, FSD-bSSFP), the target vessel image of m1=0 and the target vessel image of described each m1 value correspondence is gathered.
Described FSD preparation module is by can by 90 ° x-180 ° y-90 ° -xrf pulse sequence and asymmetrical load are at 180 ° yfSD gradient magnetic and the damage gradient magnetic composition being carried in the remaining magnetic moment of pulse train removing below on pulse both sides, refer to Fig. 3, at FSD gradient magnetic (vector) under the effect of (depending on G and δ), the phase of the spin of a flowing is determined by following formula: here, γ is gyromagnetic ratio constant, it is the flowing velocity of this spin.For one with vertical blood flow, the phase place of each spin is 0, so, there is not spin-spin phase difference, would not occur by the loose signal suppressing caused mutually of spin yet.Therefore, FSD gradient magnetic needs to be applied on the direction consistent with blood flow main flow direction.From above formula, the spin in the voxel that flowing causes is fallen apart and be result in the suppression of blood flow signal mutually, and suppression degree is determined by blood flow patterns and m1 value.Therefore, for certain specific blood flow patterns, FSD depends on m1 value to the ability that blood flow suppresses.
Wherein, FSD gradient magnetic can be added in the either direction in three directions, and its first moment m1 value determines the rejection ability of FSD to blood flow signal.G: gradient magnetic field strength, δ: gradient magnetic persistent period, τ: the rise time of gradient, S: the damage gradient magnetic removing remaining magnetic moment.M1 value as required can in the value of UI Preferences G and δ, and other parameters are: 90 ° and 180 ° of pulses continue 0.5 millisecond and 1 millisecond, τ=0.25 millisecond respectively.
The described two-dimentional bSSFP sequence by FSD preparation module, the target vessel image process gathering the target vessel image of m1=0 and described each m1 value correspondence is as follows, refer to Fig. 4, show the schematic diagram of target vessel image acquisition process, wherein, suppose the view data that continuous acquisition 11 m1 values are corresponding in once independent scanning, the value of m1 is as follows, m1=0mTms 2/ m, m1=10mTms 2/ m, m1=20mTms 2/ m ..., m1=100mTms 2/ m, when ECG (Electrocardiograph, electrocardiogram) triggering signal R arrives, after time delay TD, the segmentation bSSFP sequence adopting FSD module to prepare carries out image acquisition, gathers the target vessel image of m1=0 and the target vessel image of described each m1 value correspondence.Wherein, the gradient of FSD preparation module is applied to selects layer direction, consistent with the principal direction of blood flow, and after FSD preparation module, use Fat-suppression technique to suppress periphery fat signal on the impact of blood vessel signal, S is the damage gradient magnetic removing remaining magnetic moment.
In S205, the target vessel image subtraction that target vessel image corresponding for m1=0 is corresponding with described each m1 value is obtained bright arterial blood image corresponding to each m1 value;
In S206, the bright arterial blood image corresponding according to described each m1 value, determines actual best m1 value.
Optionally, S206 can realize in the following way: in the bright arterial blood image that described each m1 value is corresponding, choose the strong and m1 value that vein blood vessel signal contamination is weak bright arterial blood image is corresponding of arteries signal as actual best m1 value.
Optionally, S206 can realize in the following way: in the bright arterial blood image that described each m1 value is corresponding, choose target area; With described m1 value for abscissa, the signal strength values of target area is vertical coordinate curve plotting; Choose m1 value corresponding to the preset height of the ordinate value of described curve plotting for best m1 value (such as, the m1 value can getting the intermediate value place of curve vertical coordinate corresponding is best m1 value), namely strong using arteries signal and the m1 value that vein blood vessel signal contamination is weak is as best m1 value, with this m1 value three dimensional data collection later, obtain high-quality MRA image.
The acquisition methods of the best m1 value of the embodiment of the present invention has obtained experiment and has confirmed on healthy volunteer, refer to the foot arterial images that Fig. 5 is healthy volunteer, Fig. 5 a is the schematic diagram of the bright arterial images that use experience m1 value m1=160mTms2/m gathers, and Fig. 5 b is the schematic diagram of the bright arterial images using best m1 value m1=140mTms2/m to gather.As can be seen from the figure, use the image of the experience m1 value method collection of prior art to there is vein to pollute and soft tissue artifact, affect the diagnosis of angiostenosis, and the image that the optimized individual m1 value using the acquisition methods of best m1 value to obtain gathers significantly reduces above-mentioned artifact, the accuracy of diagnosis greatly can be improved.
In the present embodiment, before three dimensional data collection, obtain the actual best m1 value for individual and a certain specific part by two-dimensional imaging, with this actual best m1 value three dimensional data collection later, high-quality MRA image can be obtained.Realization can determine optimized individual m1 value simply, fast, guarantees all can obtain high-quality arterial images different patient or position, thus reduces misdiagnosis rate, ensures the blood vessel imaging means becoming a clinical practice based on the non-reinforcing MRA of FSD preparation module.
embodiment three
Fig. 6 shows the structure chart of the acquisition device of the best m1 value that the embodiment of the present invention three provides, for convenience of explanation, illustrate only the part relevant to the embodiment of the present invention, this device can be the software unit be built in armarium, hardware cell or soft or hard combining unit.
The acquisition device of described best m1 value comprises: m1 sequence generating unit 61, two-dimensional imaging unit 62 and m1 value determining unit 63.
M1 sequence generating unit 61, for generating m1 sequence, described m1 sequence comprises multiple m1 value;
Two-dimensional imaging unit 62, for carrying out two-dimensional imaging with each m1 value in m1=0 and described m1 sequence to target vessel respectively;
M1 value determining unit 63, for the view data according to two-dimensional imaging result, determines actual best m1 value.
The acquisition device of the best m1 value that the embodiment of the present invention provides can be used in the embodiment of the method one of aforementioned correspondence, and details, see the description of above-described embodiment one, do not repeat them here.
Embodiment four
Fig. 6 shows the structure chart of the acquisition device of the best m1 value that the embodiment of the present invention four provides, for convenience of explanation, illustrate only the part relevant to the embodiment of the present invention, this device can be the software unit be built in armarium, hardware cell or soft or hard combining unit.
The acquisition device of described best m1 value comprises: m1 sequence generating unit 71, two-dimensional imaging unit 72 and m1 value determining unit 73.
The difference of the present embodiment and embodiment three is:
Optionally, described m1 sequence generating unit 71 comprises: emulation module 711 and generation module 712.
Emulation module 711, for emulating the best m1 value of the theory obtaining current blood flow patterns;
Generation module 712, for taking predetermined interval as ladder, in the multiple m1 value of each sampling in described theory best m1 value left and right, according to the m1 value that the best m1 value of described theory and sampling obtain, generates m1 sequence.
Optionally, described m1 value determining unit 73 comprises: image capture module 731, image processing module 732 and m1 determination module 733.
Image capture module 731, the target vessel image that target vessel image and described each m1 value for gathering m1=0 are corresponding;
Image processing module 732, obtains bright arterial blood image corresponding to each m1 value for the target vessel image subtraction that target vessel image corresponding for m1=0 is corresponding with described each m1 value respectively;
M1 determination module 733, for the bright arterial blood image corresponding according to described each m1 value, determines actual best m1 value.
Optionally, described image capture module 731, specifically for the two-dimentional bSSFP sequence prepared by FSD, gathers the target vessel image of m1=0 and the target vessel image of described each m1 value correspondence.
Described m1 determination module 733, specifically for choosing target area in the bright arterial blood image that described each m1 value is corresponding, with described m1 value for abscissa, the signal strength values of target area is vertical coordinate curve plotting, and the m1 value choosing the preset height of the ordinate value of described curve plotting corresponding is best m1 value.
The acquisition device of the best m1 value that the embodiment of the present invention provides can be used in the embodiment of the method two of aforementioned correspondence, and details, see the description of above-described embodiment two, do not repeat them here.
It should be noted that in said apparatus embodiment, included unit is carry out dividing according to function logic, but is not limited to above-mentioned division, as long as can realize corresponding function; In addition, the concrete title of each functional unit, also just for the ease of mutual differentiation, is not limited to protection scope of the present invention.
In addition, one of ordinary skill in the art will appreciate that all or part of step realized in the various embodiments described above method is that the hardware that can carry out instruction relevant by program has come, corresponding program can be stored in a computer read/write memory medium, described storage medium, as ROM/RAM, disk or CD etc.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. an acquisition methods for optimum magnetic field gradient first moment m1 value, described method comprises:
Generate m1 sequence, described m1 sequence comprises multiple m1 value;
With each m1 value in m1=0 and described m1 sequence, two-dimensional imaging is carried out to target vessel respectively;
According to the view data of two-dimensional imaging result, determine actual best m1 value;
The described view data according to two-dimensional imaging result, determine that actual best m1 value is specially:
Gather the target vessel image of m1=0 and the target vessel image of described each m1 value correspondence;
The target vessel image subtraction that target vessel image corresponding for m1=0 is corresponding with described each m1 value is respectively obtained bright arterial blood image corresponding to each m1 value;
The bright arterial blood image corresponding according to described each m1 value, determines actual best m1 value;
The described bright arterial blood image corresponding according to described each m1 value, determine that actual best m1 value is specially:
Target area is chosen in the bright arterial blood image that described each m1 value is corresponding;
With described m1 value for abscissa, the signal strength values of target area is vertical coordinate curve plotting;
The m1 value choosing the preset height of the ordinate value of described curve plotting corresponding is best m1 value.
2. the method for claim 1, is characterized in that, described generation m1 sequence is specially:
Emulation obtains the best m1 value of theory of current blood flow patterns;
Take predetermined interval as ladder, in the multiple m1 value of each sampling in described theory best m1 value left and right, according to the m1 value that the best m1 value of described theory and sampling obtain, generate m1 sequence.
3. the method for claim 1, is characterized in that, the target vessel image of described collection m1=0 and the target vessel image of described each m1 value correspondence are specially:
The two-dimension balance steady state free precession bSSFP prepared by FSD, gathers the target vessel image of m1=0 and the target vessel image of described each m1 value correspondence.
4. an acquisition device for best m1 value, described device comprises:
M1 sequence generating unit, for generating m1 sequence, described m1 sequence comprises multiple m1 value;
Two-dimensional imaging unit, for carrying out two-dimensional imaging with each m1 value in m1=0 and described m1 sequence to target vessel respectively;
M1 value determining unit, for the view data according to two-dimensional imaging result, determines actual best m1 value;
Described m1 value determining unit comprises:
Image capture module, the target vessel image that target vessel image and described each m1 value for gathering m1=0 are corresponding;
Image processing module, obtains bright arterial blood image corresponding to each m1 value for the target vessel image subtraction that target vessel image corresponding for m1=0 is corresponding with described each m1 value respectively;
M1 determination module, for the bright arterial blood image corresponding according to described each m1 value, determines actual best m1 value;
Described m1 determination module, specifically for choosing target area in the bright arterial blood image that described each m1 value is corresponding, with described m1 value for abscissa, the signal strength values of target area is vertical coordinate curve plotting, and the m1 value choosing the preset height of the ordinate value of described curve plotting corresponding is best m1 value.
5. device as claimed in claim 4, it is characterized in that, described m1 sequence generating unit comprises:
Emulation module, for emulating the best m1 value of the theory obtaining current blood flow patterns;
Generation module, for taking predetermined interval as ladder, in the multiple m1 value of each sampling in described theory best m1 value left and right, according to the m1 value that the best m1 value of described theory and sampling obtain, generates m1 sequence.
6. device as claimed in claim 4, it is characterized in that, described image capture module, specifically for the two-dimension balance steady state free precession FSD-bSSFP prepared by FSD, gathers the target vessel image of m1=0 and the target vessel image of described each m1 value correspondence.
7. an armarium, is characterized in that, described armarium comprises the acquisition device of the best m1 value described in claim 4 to the arbitrary claim of claim 6.
CN201210584523.6A 2012-12-28 2012-12-28 Obtaining method and device and medical equipment of optimum m1 value Withdrawn - After Issue CN103083021B (en)

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Granted publication date: 20150617

Effective date of abandoning: 20200403

AV01 Patent right actively abandoned