CN103068427A

CN103068427A - Dry-powder inhaler

Info

Publication number: CN103068427A
Application number: CN2011800412523A
Authority: CN
Inventors: A·科隆; Z·萨拉克
Original assignee: Valois SAS
Current assignee: Aptar France SAS
Priority date: 2010-07-07
Filing date: 2011-07-05
Publication date: 2013-04-24
Anticipated expiration: 2031-07-05
Also published as: FR2962338A1; CN103068427B; FR2962338B1; WO2012004514A1

Abstract

The invention relates to a dry-powder inhaler (100), comprising a body (110) containing a dispersion chamber (111), a lid (130) pivotably mounted on said body between a closed position and an open position, said lid comprising a dispensing opening (131) through which said user inhales, the inhaler further comprising a loading opening (121) receiving a capsule (10) containing a dose of dry powder to be inhaled, the inhaler comprising a sliding member (140) interlocking with said lid (130), the movement of said lid from the open position thereof to the closed position thereof translatably moving said sliding member sideways so as to open the capsule arranged in said loading opening (121).

Description

Dry powder inhaler

Technical field

The present invention relates to a kind of dry powder inhaler.

Background technology

Inhaler is known in the art.There is different types of inhaler.First kind inhaler comprises the container of the powder that holds many dosage, and described inhaler is provided with dosing member, can separate this powder of a dosage when each the actuating from container, takes in the discharge line with the powder with this dosage, in order to distribute to user.The inhaler of another type is the dosage of powder is arranged in the single container of predetermined close, then opens in these containers when each actuated inhaler.This implements to guarantee the better sealing of powder, because each dosage only just is opened in the moment of its discharge.In order to realize these single containers, various modification have been proposed, such as a microscler blister strip or be arranged in some vesicles on the rotating circular disk.The inhaler of above-described any type with existing has and their structure and the merits and demerits relevant with their operation.Therefore, for some inhaler, its problem is to decide when activating accuracy and the repdocutbility of dosage at every turn.Equally, the effectiveness of distribution that is to say effectively to enter into user pulmonary to obtain the dosage part of useful therapeutic effect, also is the problem that the inhaler of some has.About opening of single container, proposed to peel off or open confining bed.This shortcoming that has be difficult to control to apply in order to guarantee to open fully but without the power of opening the danger of next container, if device for opening needs activate by sucking especially.Another problem that the inhaler of outfit blister strip has is relevant with the storage of the used part of the movement of band and band.Therefore, according to the length of band and/or the thickness of vesicle, large space can be proved to be the good operation that any clamping stagnation essential and blister strip can hinder inhaler.In addition, when the forward gear of band when simultaneously the leading section of traction belt is bad to avoid coiling, along with actuating, especially because increasing gradually with the diameter of being with of coiling can cause problem.Therefore, multi-dose inhaler and the normally complicated device of the inhaler that holds blister strip, it is comprised of a large amount of parts, and the cost height of therefore making and assembling.In order to realize so also complicated so the not high device of cost, proposed to have for example inhaler of bladder of single container, single container just in time was loaded into inhaler before using inhaler.The advantage of this class device is the inside that does not need all dosage is stored in equipment, so that the size of equipment can reduce.By contrast, use more complicated because user must be loaded into inhaler with a bladder before each the use.In addition, other proprietary shortcoming of this class bladder formula inhaler also shows.Therefore, this class device is comprised of two parts usually, and one of them parts is equipped with the termination, oral cavity.When this class device of operation, in order to open bladder and to discharge powder, perhaps in order to discharge empty bladder after sucking, the finger of user contacts with the termination, oral cavity usually, and this can have the risk of infection.Equally, in order to discharge empty bladder, device need to be opened usually, and this interior exposed that makes device is in any external contamination, and when sucked next time, external contamination may be passed to user subsequently.

Summary of the invention

Target of the present invention is to propose a kind of dry powder inhaler, and it no longer produces above-mentioned shortcoming.

Especially, target of the present invention is to propose such inhaler, and the cost of its manufacturing and assembling is low and simple, be easy to use, and as much as possible restriction is infected and/or the risk of pollution.

Therefore, target of the present invention is a kind of dry powder inhaler, and it has: hold the main body of disperseing the chamber; At the housing that is pivoted between closed position and the open position on the described main body, described housing has dispensing orifice, user sucks by dispensing orifice, inhaler also has the load port of admitting a bladder, bladder accommodates dosage dry powder to be sucked, inhaler has the sliding component that engages with described housing, and the movement of described housing from its open position to its closed position moved the laterally translation of described sliding component, in order to open the bladder that is placed in the described load port.

Advantageously, described bladder have upper part and with the separable lower part of described upper part, when described housing was got back to its closed position, described sliding component divided with described bottom and cooperates, with so that described lower part separate with described upper part.

Advantageously, described sliding component has at least one dentition, described dentition with cooperate at least one tooth parts that is connected with described housing aspect the rotation.

Advantageously, described sliding component is disposed in the location right of inhaler below the described load port, and described sliding component has: the first opening, described the first opening be arranged to when described housing during at open position facing to described load port; And second opening, described the second opening be arranged to when described housing during in the closed position facing to described load port.

Advantageously, when bladder was inserted in the described load port, the described lower part of bladder was passed described first opening of described sliding component.

Advantageously, plate segment is fixed on the described main body, and described plate segment has described load port and is used for the guide member guide described sliding component translation to move.

Advantageously, described guide member has the track that cooperates with the projection of described sliding component.

Description of drawings

By the detailed description of doing below with reference to the accompanying drawing that provides as limiting examples, these feature and advantage of the present invention and further feature and advantage show clearlyer, in the accompanying drawing:

-Fig. 1 is the schematic, exploded perspective view of the distributor of one favourable embodiment according to the present invention,

-Fig. 2 is the cross-sectional schematic view of the device of Fig. 1, is in the closed position before using for the first time,

-Fig. 3 is and the similar view of the view of Fig. 2, but is in the open position, and has a bladder that is installed in the load port,

-Figure 4 and 5 are and the similar view of the view of Fig. 2, but are in the process that housing is closed and bladder is opened,

-Fig. 6 is and the similar view of the view of Fig. 2, but is in the closed position before sucking,

-Fig. 7 is and the similar view of the view of Fig. 6, but is in the closed position in the suction process,

-Fig. 8 is and the similar view of the view of Fig. 3, but is in the open position,

-Fig. 9 and 10 is perspective schematic view of the device of Fig. 1, is in respectively closed position and open position, and

-Figure 11 and 12 is schematic sectional perspective views, is in respectively closed position and open position.

The specific embodiment

Accompanying drawing has been described of the present invention one favourable embodiment.In this embodiment, inhaler 100 has main body 110, and main body is hollow and has upper shed and under shed.The plate segment 120 that upper shed is fixed on the described main body is closed at least in part, and closing component such as valve 150 that under shed is pivoted on the described main body 110 are closed.Be equipped with the sliding component 140 with dentition between under the plate segment 120.Advantageously, plate segment 120 has guide member, and such as track 129, guide member cooperates with the projection 149 of sliding component 140, moves in order to the translation that guides described sliding component.The housing 130 that pivots is assembled on the described plate segment 120.This housing 130 has dispensing orifice 131, and dispensing orifice is preferably formed in the end, oral cavity, and in order to suck, user will make its mouth around the termination, oral cavity.Thereby, as especially visible on Fig. 1, formed by five major parts according to the device of this embodiment, i.e. main body 110, plate segment 120, sliding component 140, housing 130 and valve 150.All these parts are assembled on another by 160 1 on axle, and axle passes the side opening 115 that is located in the main body 110, pass the side opening 135 that is fit to of housing 130 and the hollow cylinder 155 that passes in the part that is arranged in valve 150 passes through.At least one tooth parts 161,162 is installed on the described axle 160, in order to be arranged on sliding component 140 at least one dentition 145 cooperate.In the example shown, two

tooth parts

161 and 162 that are installed on the axle 160 are arranged, so sliding component 140 also has two

dentitions

145 and 146, its operation will be described below.Suitable fixed component 163 can be set, in order to described axle 160 is fixed on the described main body 110 in non-removable mode by different ingredients is assembled with each other.As visible on Fig. 1, axle 160 preferably has a special cross section, substantially square cross section for example, and tooth parts also has similar cross section, so that tooth parts and axle 160 are connected aspect rotation.Equally, housing 130 also has the opening 135 of analogous shape, so that housing, tooth parts and described axle 160 are connected aspect rotation.Plate segment 120 has load port 121, load port advantageously dispose at least one, preferred three location ribs 125, the location rib advantageously distributes regularly around described load port 121.The mode that these ribs allow to clamp locates bladder 10 and remain in the position of hope.Especially, bladder 10 has upper part 11 and the lower part 12 that can separate with described upper part, described rib 125 be used for before described lower part 12 is separated and keep between separation period described on part 11.In addition, this plate segment 120 also advantageously has housing region 122, and housing region is formed by the zone that disposes a plurality of holes 123, and hole can be placed one or more deposit bladder.This so that user always have a plurality of for bladder, for example when its whilst on tour.In this hypothesis, after the each use of device, user only need utilize the bladder in this container to be loaded into next bladder in load port 121.Certainly, such bladder container is not absolutely necessary for the operation of device.

Fig. 2 to 8 illustrates the cycle of operation according to the device of this embodiment.With reference to Fig. 2, before being illustrated in and using for the first time, Fig. 2 is in the device of closed position, and visible body 110 limits in inside disperses chamber 111, and the dispersion chamber will be for the powder that receives after bladder 10 is opened.Fig. 3 illustrates housing 130 and opens device afterwards.As seen because the cooperating of the hole 135 of the about square shape of axle 160 and the respective shapes of described housing 130, housing 130 open the rotation that causes axle 160.This of axle 160 rotates and therefore also causes the rotation of

tooth parts

161 and 162, and tooth parts rotates with described axle 160.These

tooth parts

161 and 162 rotation cause the sidesway of sliding component 140.In fact, especially shown on Fig. 2, the tooth 165 of tooth parts 161 is engaged in the dentition 145 of sliding component 140.Therefore between Fig. 2 and 3, the rotation of the tooth 165 of visible tooth parts will make sliding component 140 slide towards the right on the figure.Certainly, utilize the second tooth parts 162 also to carry out the same slip at the device opposite side, invisible on the cut away view.Certainly, only tooth parts may be enough to cause the movement of described sliding component.When housing 130 was opened, valve 150 is and then axle 160 rotations not.On the contrary, housing 130 open last, housing cooperates with described valve 150, and especially cooperates with sweep 151, the valve part that sweep is mounted on the hollow cylinder 155 on the axle 160 and seals main body 110 bottoms in the closed position of valve.This cooperation between housing 130 and the valve 150 makes valve center on the open position upset of described axle 160 shown on Fig. 3.So, in this position that housing 130 is opened fully, valve 150 is opened and disperses the inside thing in chamber 111 to be discharged into outside the device.Fig. 3 also illustrates the bladder 10 that is placed in position in load port 121.As seen the upper part 11 of bladder is maintained in the rib 125 that is arranged on 121 li of described load port in the mode that clamps.In addition, the lower part 12 of bladder is passed the first opening 141, the first openings and is implemented in the described sliding component 140, and in the open position of housing 130, the first opening surface is facing to described load port 121.

Fig. 4 to 6 illustrates the dwell period that bladder 10 is loaded rear housing 130.Therefore, as on Fig. 4 as seen, when user is closed housing 130 again, valve 150 also will be closed again, and by

tooth parts

161 and 162 with the dentition of described sliding component 140 between cooperate, sliding component 140 will be with the left side on the figure.Yet shown on Fig. 4, the lower part 12 of bladder 10 is passed the first opening 141 of described sliding component 140, and the sidesway of this sliding component will make 12 fractures of lower part and/or the distortion of bladder 10.The upper part 11 of bladder 10 still is maintained in the load port 121 in the mode that clamps certainly, is especially kept by rib 125.On the contrary, lower part 12 will separate with upper part 11 and the dispersion chamber 111 of dropping in because the first opening 141 of described sliding component 140 has the larger diameter of overall diameter than the described lower part 12 of bladder.Therefore, be not only that powder will be poured on the inside that disperses chamber 111, and the lower part 12 of holding described powder will drop on the bottom in described dispersion chamber 111, so that lower part is emptied.In the position of Fig. 5, visible housing 130 just in time arrives before its closed position.In this position, be arranged in described housing 130 parts protruding pin 135 will be left on load port 121 in the upper part 11 of bladder 10 cooperate.So, shown in clear on Fig. 5 and 6, when housing 130 is closed fully, protruding pin 135 will cause that the upper part 11 of bladder is from load port 121 towards disperseing chamber 111 inner discharges.Therefore, in this position of Fig. 6, when device is closed again fully, bladder 10 is fragmented into two parts, and upper and lower two

parts

11 and 12 of bladder 10 are put on (being formed by the valve 150) bottom that leans against in the dispersion chamber 111 and powder is discharged to beyond the described part of bladder at least in part.So device is ready for suction.

Fig. 7 illustrates sucting stage.In order to suck, user makes its mouth around the dispensing orifice 131 of housing 130 and air-breathing along the direction of the arrow B that illustrates on Fig. 7.So do, disperseing chamber 111 interior generation air flows, air flow will make two

parts

11 and 12 of bladder carry out eddying motion in described dispersion chamber 111.On Fig. 7, will be allowed being emptied completely of described part of bladder by this eddying motion shown in the arrow C, also have the fine dispersion of powder, and the pile of grounds that especially may form be not coalescent.When needed, can disperse intracavity that the inlet port that replenishes air is set, with the eddying motion that is beneficial to inlet flow.The powder of eddying motion thereby will pass the second opening 142 that is arranged in the sliding component 140 and be inhaled into stream and be discharged to and disperse to suck the position at this outside the chamber 111, the second opening on one side facing to disperseing chamber 111 another side facing to load port 121.As more clearly visible on Figure 11, housing 130 advantageously has aperture plate 137, and powder can be discharged from by aperture plate and towards the direction of dispensing orifice 131.Aperture plate especially avoids the

part

11,12 of bladder also to be discharged to beyond the dispersion chamber.So, user sucks a dosage powder that is contained at first in the bladder 10.Advantageously, described dispersion chamber can have the truncated cone shape of dwindling towards the direction of dispensing orifice 131, especially accelerates inlet flow in order to the direction towards described hole.

After the suction, user is opened housing 130 again, and as before, this will make valve 150 overturning at last of opening.This upset of the valve 150 that illustrates on Fig. 8 will allow to discharge the

bladder part

11 and 12 of two skies that disperse chamber 111.In this position of Fig. 8, therefore device is ready for next time and uses.Certainly, if use next time is not immediately, user is shutoff device and wait for and to reopen device next time when needing again.As modification, user is not to discharge empty bladder part after each the suction, but he can only discharge empty bladder part certainly when his next device for opening is wanted to load new bladder.

Advantageously, especially shown on Fig. 1, valve 150 can have one or more fixedly protruding pins 156, and in the closed position, fixedly protruding pin is buckled in the bottom of main body 110 lightly, closes the safe and reliable of closed position valve 150 guaranteeing.Figure 11 and 12 illustrates the opening 116 in the bottom that is arranged in main body 110, and the protruding pin 156 of the described buckle of valve can pass these openings to be passed through.Certainly, this buckle is not very strong, in order to can not fetter opening of valve when user is opened housing 130.

Fig. 9 and 10 illustrates device at the perspective view of closed position and open position, and Figure 11 and 12 is the views that are similar to Fig. 9 and 10, but is partly dissectd, and is illustrated in the internal structure of installing in these two positions.

Device of the present invention is therefore simple especially and exquisite.It is comprised of a small amount of part, and the cost of therefore making and assembling is low.In addition, the bladder part of the sky of the existence in dispersion chamber and eddying motion is so that powder is not coalescent and guarantee that therefore powder is dispensed to user better when sucking.At last, the discharge of empty bladder part does not need stripping device, and this has limited the pollution risk of device.Do not had taking apart of device also to avoid the again risk of assembling device, or forgotten the risk of disengaging section for the moment, especially for child or old people.And, the operation of device, i.e. the opening and closing of housing 130 needn't operate the part that forms the termination, oral cavity around dispensing orifice 131.When needed, can consider be used to the special grip portion that operates described cover cap.Therefore the infection risk at dispensing orifice 131 places also is restricted.The using method of device is therefore very simple, and user is only mobile in order to actuating device fully between two end position with housing.Therefore, he at first opens housing, then inserts bladder, closes housing again and sucks.

For those skilled in the art, various modifications also are possible, do not exceed the scope of the present invention of determining as by appended claims.They can make up the various features of the device that describes with reference to the accompanying drawings especially, and function in any suitable manner.

Claims

1. a dry powder inhaler (100), it has: hold the main body (110) of disperseing chamber (111); At the housing (130) that is pivoted between closed position and the open position on the described main body, described housing has dispensing orifice (131), user sucks by described dispensing orifice, dry powder inhaler also has the load port (121) of admitting a bladder (10), described bladder accommodates dosage dry powder to be sucked, it is characterized in that, dry powder inhaler has the sliding component (140) that engages with described housing (130), the movement of described housing from its open position to its closed position moved the laterally translation of described sliding component, in order to open the bladder that is placed in the described load port (121).

2. dry powder inhaler according to claim 1, it is characterized in that, described bladder (10) have upper part (11) and with the separable lower part of described upper part (12), when described housing (130) is got back to its closed position, described sliding component (140) cooperates with described lower part (12), uses so that described lower part is separated with described upper part (11).

3. dry powder inhaler according to claim 1 and 2, it is characterized in that, described sliding component (140) has at least one dentition (145,146), described dentition with cooperate at least one tooth parts that is connected with described housing (130) aspect the rotation (161,162).

4. according to each described dry powder inhaler in the claims, it is characterized in that, described sliding component (140) is disposed in the location right of Diskus below the described load port (121), described sliding component (140) has: the first opening (141), described the first opening be arranged to when described housing (130) during at open position in the face of described load port (121); And second opening (142), described the second opening be arranged to when described housing (130) during in the closed position in the face of described load port (121).

5. dry powder inhaler according to claim 4 is characterized in that, when bladder (10) was inserted in the described load port (121), the described lower part (12) of bladder was passed described first opening (141) of described sliding component (140).

6. according to each described dry powder inhaler in the claims, it is characterized in that, plate segment (120) is fixed on the described main body, and described plate segment (120) comprises described load port (121) and is used for the guide member (129) guide described sliding component (140) translation to move.

7. dry powder inhaler according to claim 6 is characterized in that, described guide member has the track (129) that cooperates with the projection (149) of described sliding component (140).