CN103059493B - Functionalized nano particles with diamino triazine functional groups as well as preparation and application method thereof - Google Patents
Functionalized nano particles with diamino triazine functional groups as well as preparation and application method thereof Download PDFInfo
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- CN103059493B CN103059493B CN201210510090.XA CN201210510090A CN103059493B CN 103059493 B CN103059493 B CN 103059493B CN 201210510090 A CN201210510090 A CN 201210510090A CN 103059493 B CN103059493 B CN 103059493B
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Abstract
The invention discloses functionalized nano particles with diamino triazine functional groups as well as a preparation and an application method of the nano particles. The average particle size of the functionalized nano particles is 10-1000nm; and the functionalized nano particles of which the surface have the diamino triazine functional groups are obtained according to the following method: based on 2-vinyl-4, 6-diamino-1, 3, 5-triazine as a functional monomer, initiating the homopolymerization of the functional monomer or the copolymerization of the functional monomer and other auxiliary monomers by a free radical initiator according to the principle of the free radical polymerization. The functionalized nano particles disclosed the invention have large surface area and volume ratio, controllable particle size, good latex stability and good compatibility with a biological test sample by using water as a dispersing agent, and can be used directly. A strong hydrogen bond bonding is formed in aqueous solution by the diamino triazine functional groups on the surface of the functionalized nano particles and uric acid, nucleic acid base, nucleotide, nucleoside, desoxyribonucleic acid, protein and the like, so that strong selective adsorption is generated, and the functionalized nano particles can be applied to the fields such as drug delivery, chemical catalysis, material separation and purification, sensor technology, and analysis technology.
Description
Technical field
The invention belongs to technical field of function materials, in particular to the nanoparticle of diamino triazine functional group functionalization, also relate to the preparation and application of such nanoparticle simultaneously.
Background technology
2-vinyl-4,6-diamino-1,3,5-triazines be one commercial function monomer (its chemical constitution is C
5h
7n
5), 2-vinyl-4 can be obtained by the method for radical polymerization, 6-diaminostilbene, 3, the homopolymer of 5-triazine or with the multipolymer of other monomer (as Publication about Document all has report: 1. H. Asanuma, S. Gotoh, T. Ban, M. Komiyama, Chem. Lett. 1996, 681. 2. H. Asanuma, T. Ban, S. Gotoh, T. Hishiya, M. Komiyama, Supramolecular Sci., 1998, 5, 405. 3. O. Slinchenko, A. Rachkov, H. Miyachi, M. Ogiso, N. Minoura, Biosens. Bioelectron., 2004, 20, 1091.).This homopolymer or multipolymer optionally can adsorb a series of target molecule or the unit with specified chemical the Nomenclature Composition and Structure of Complexes, comprise uric acid, nucleic acid base, Nucleotide, nucleosides, thymus nucleic acid and protein etc.Adsorption mechanism is that the diamino triazine functional pendant groups on this homopolymer or multipolymer (can comprise the aqueous solution) in the solution with target molecule or unit and forms strong hydrogen bond.But solvability is limited in many solvents for 2-vinyl-4,6-diamino-1,3,5-triazines monomer and poly-(2-vinyl-4,6-diamino-1,3,5-triazines).Restrict by this, the polymerization of relevant 2-vinyl-4, the 6-diamino-1,3,5-triazines reported in document is so far all carry out in organic solvent (such as dimethyl sulfoxide (DMSO)), the precipitation aggregate of prepared just this polymkeric substance or direct formation of film at surface.Relevant 2-vinyl-4, 6-diaminostilbene, 3, the research of 5-triazine homopolymer and multipolymer application be also only confined to use through pulverizing mill and the powder that obtains or the polymeric film obtained by being polymerized (as Publication about Document all has report: 1. M. Ogiso, N. Minoura, T. Shinbo, T. Shimizu, Biosens. Bioelectron., 2007, 22, 1974. 2. Z. Cao, W. Liu, D. Liang, G. Guo, J. Zhang, Advanced Functional Materials, 2007, 17, 246. 3. L. Tang, Y. Yang, T. Bei, W. Liu, Biomaterials, 2011, 32, 1943.).
Nanoparticle refers to that size is less than the various particles of 1 micron, all has huge application potential in a lot of fields, such as drug conveying, chemical catalysis, separating substances and purifying, sensing technology, analytical technology etc.At present, both at home and abroad also not about with 2-vinyl-4,6-diamino-1,3,5-triazines for function monomer, by the method preparation of high molecular polymerization or the bibliographical information using diamino triazine functional group functional nanoparticle.
Summary of the invention
An object of the present invention is to provide a series of diamino triazine functional groups functional nanoparticle and preparation method thereof, and to obtain having various size, shape and composition structure, and surface is with the nanoparticle of diamino triazine functional group.
Another object of the present invention is to provide the using method of a kind of described diamino triazine functional group functional nanoparticle, using the nanoparticle prepared by the present invention as carrier, realize the absorption to sample molecule or unit (such as drug molecule, thymus nucleic acid, protein etc.).The fields such as (but being not limited to) drug conveying, chemical catalysis, separating substances and purifying, sensing technology, analytical technology can be applied to.
First object of the present invention is achieved in that
A kind of diamino triazine functional group functional nanoparticle, its average particle size is 10-1000 nanometer, and surface is with diamino triazine functional group.
The preparation method of a kind of above-mentioned diamino triazine functional group functional nanoparticle, with 2-vinyl-4,6-diaminostilbene, 3,5-triazine is as function monomer, according to the principle of radical polymerization, adopt radical initiator cause described function monomer homopolymerization or with other auxiliary monomer copolymerization, specifically comprise the following steps:
1) by described function monomer separately or be dissolved among organic solvent together with described auxiliary monomer;
2) by described radical initiator separately or among the mixture being dissolved in water or damping fluid or water and organic solvent together with described auxiliary monomer or organic solvent;
3) mixture or the organic solvent of water or damping fluid or water and organic solvent is added to the reactor with whipping appts, add simultaneously or do not add radical initiator, logical rare gas element under whipped state again, and temperature control is to 60-75 C or provide rayed or apply sound wave;
4) by step 1) and step 2) solution prepared is metered among the reactor of step 3) respectively continuously or discontinuously with controlled speed;
5) after for some time is carried out in reaction, the initial product obtained is carried out purifying, finally the obtained latex containing diamino triazine functional group functional nanoparticle.
The preparation method of a kind of above-mentioned diamino triazine functional group functional nanoparticle, with 2-vinyl-4,6-diaminostilbene, 3,5-triazine is as function monomer, according to the principle of radical polymerization, adopt radical initiator cause described function monomer homopolymerization or with other auxiliary monomer copolymerization, specifically comprise the following steps:
1) with in the reactor of whipping appts, under whipped state, temperature control is to 60-75 C or provide rayed or apply sound wave, by described function monomer separately or among the mixture being dissolved in water or damping fluid or water and organic solvent together with described auxiliary monomer or organic solvent;
2) under whipped state, in described reactor, rare gas element is led to;
3) described radical initiator or its solution are joined in described reactor;
4) after for some time is carried out in reaction, the initial product obtained is carried out purifying, finally the obtained latex containing diamino triazine functional group functional nanoparticle.
A preparation method for above-mentioned diamino triazine functional group functional nanoparticle, with the mixture of water or damping fluid or water and organic solvent or organic solvent for dispersion agent, preparation is containing the dispersion system of particle in advance; With 2-vinyl-4,6-diaminostilbene, 3,5-triazine as function monomer, according to the principle of radical polymerization, radical initiator is adopted to cause described function monomer homopolymerization or the method with other auxiliary monomer copolymerization, prepare with 2-vinyl-4,6-diaminostilbene, 3,5-triazine homopolymer or be shell with the multipolymer of auxiliary monomer, the core-shell structure nanometer particle that is core with the particle prepared in advance, specifically comprise the following steps:
1) by described function monomer separately or be dissolved among organic solvent together with described auxiliary monomer;
2) by described radical initiator separately or among the mixture being dissolved in water or damping fluid or water and organic solvent together with described auxiliary monomer or organic solvent;
3) particle in the mixture or organic solvent being dispersed in water or damping fluid or water and organic solvent is added to the reactor with whipping appts, logical rare gas element under whipped state again, and temperature control is to 60-75 C or provide rayed or apply sound wave;
4) by step 1) and step 2) solution prepared, be metered into continuously or discontinuously among described reactor with controlled speed respectively;
5), after for some time is carried out in reaction, the initial product obtained is carried out purifying, finally obtained containing the latex of surface with the core-shell structure nanometer particle of diamino triazine functional group.
The preparation method of above-mentioned diamino triazine functional group functional nanoparticle, wherein said radical initiator is single-component radical initiator, two component or multi-component radical initiator; Described auxiliary monomer is the mixture of one or more compounds, the molecule of each auxiliary monomer with one or two above can with the group of described function monomer generation radical copolymerization.
The preparation method of above-mentioned diamino triazine functional group functional nanoparticle, wherein said radical initiator is preferably 2,2'-azo two (2-methyl-prop amidine) dihydrochloride, azo-bis-isobutyl cyanide; Described auxiliary monomer is preferably vinylbenzyltrimethyl ammonium chloride, trimethylolpropane trimethacrylate.
The preparation method of above-mentioned diamino triazine functional group functional nanoparticle, the wherein said particle prepared in advance is following one or more: macromolecule material particle, inorganic material particle, metallic material particles, composite material granular.
Second object of the present invention is achieved in that
The using method of a kind of diamino triazine functional group functional nanoparticle, utilize the diamino triazine functional group of described nanoparticle surface to combine by forming strong hydrogen bonding, thus optionally absorption has the target compound of specified chemical the Nomenclature Composition and Structure of Complexes, comprises the following steps:
1) by described containing the latex of diamino triazine functional group functional nanoparticle and the solution of target compound or contain the mixture solution of target compound or dispersion system fully mixes;
2) the diamino triazine functional group functional nanoparticle being adsorbed with target compound is separated with above-mentioned mixed solution, obtains the nanoparticle being adsorbed with target compound and/or the liquid be purified.
Preferably, described target compound comprises by forming hydrogen bonded, all molecules, ion, chemical structural units and the particle that adsorb to occur with diamino triazine functional group.In one particular embodiment of the present invention, described target compound is 5 FU 5 fluorouracil (5-FU).
Compare with using method with existing 2-vinyl-4,6-diamino-1,3,5-triazines Macroscopic single crystal, the diamino triazine functional group's functional nanoparticle that the present invention relates to and preparation and application tool thereof have the following advantages and progress significantly:
(1) the diamino triazine functional group functional nanoparticle prepared has that surface-to-volume ratio is large, and size of particles is controlled, and latex stability is good, and latex can use water as dispersion agent, good with biological material compatibility, the advantage such as directly can to use.
(2) the diamino triazine functional group of described nanoparticle surface and uric acid, nucleic acid base, Nucleotide, nucleosides, thymus nucleic acid and protein etc. are utilized to form strong hydrogen bonded in aqueous, thus produce strong selectivity absorption, the field such as drug conveying, chemical catalysis, separating substances and purifying, sensing technology, analytical technology can be applied to.
Accompanying drawing explanation
Fig. 1 is the reaction formula of 2-vinyl-4,6-diamino-1,3,5-triazines and the radical polymerization of vinylbenzyltrimethyl ammonium chloride in the embodiment of the present invention one.
Fig. 2 is the reaction formula of 2-vinyl-4,6-diamino-1,3,5-triazines and the polymerization of TRIM radical crosslinking in the embodiment of the present invention two.
Fig. 3 is the schematic diagram of diamino triazine functional group provided by the present invention functional nanoparticle absorption 5-FU example.
Fig. 4 be change and the 5-FU calibration curve of 5-Fluracil (5-FU) concentration of aqueous solution before and after the absorption of diamino triazine functional group of the present invention functional nanoparticle contrast figure.
Embodiment
Restriction to the present invention program is not all formed to the description of embodiment below, the technical scheme provided according to applicant can have the change of various ways, listed all compounds and starting material and formula thereof, proportioning are all as illustrating, described preparation method is only the object of demonstration, any restriction is not formed to the present invention, can change as required in actually operating.Such as, applicant can be with positive charge or with negative charge or the radical initiator without electric charge at aforementioned radical initiator; Can be single-component radical initiator, also can be two component or multi-component radical initiator, such as redox initiator.And for example, aforementioned auxiliary monomer can be single compound, also can be two kinds or two or more compounds; Can be charged (positive charge or negative charge), also can be uncharged.Also as, each molecule of mentioned auxiliary monomer can with one can with the group of described function monomer generation radical copolymerization, also can with two or more can with the group of described function monomer generation radical copolymerization.Use the former to produce linear copolymer with diamino triazine functional group, use latter to produce cross-linking copolymer with diamino triazine functional group.And then as, the particle prepared in advance that the core-shell structure nanometer particle that aforesaid preparation table wears diamino triazine functional group uses can be the particle of differing materials, such as macromolecule material particle or inorganic material particle or metallic material particles or composite material granular etc.Again and as, in the using method of aforesaid described diamino triazine functional group functional nanoparticle, described target compound comprises by forming hydrogen bonded, all molecules, ion, chemical structural units and the particle etc. that adsorb to occur with diamino triazine functional group.
The preparation of embodiment one 2-vinyl-4,6-diamino-1,3,5-triazines linear polymer nanoparticle
The nanoparticle formula for raw stock that the present embodiment prepares diamino triazine functional group functionalization lists in table 1.
The formula for raw stock of diamino triazine functional group functional nanoparticle prepared by table 1
| Material | Composition | Weight/volume |
| 2-vinyl-4,6-diamino-1,3,5-triazines | Function monomer | 190-200 gram |
| Vinylbenzyltrimethyl ammonium chloride | Auxiliary monomer | 0-10.0 gram |
| 2,2'-azo two (2-methyl-prop amidine) dihydrochloride (V-50) | Radical initiator | 1.0-5.0 gram |
| Dimethyl sulfoxide (DMSO) | Organic solvent | 1.5-2.0 litre |
| Deionized-distilled water | Water solvent | 6.0-8.5 litre |
First, the glass reactor of 10 liters of sandwichs is prepared.This reactor is equipped with mechanical stirring device, condenser, nitrogen input and output, the glass storage bottle of two 2.5 liters, the oil circulation device from the digital temperature control of microprocessor pump drive, temperature monitoring probe and coupled band that two storage bottles are reinforced in reactor.This oil circulation device is used for the turning oil of the interlayer conveying temperature control to reactor.In a storage bottle, in the middle of the dimethyl sulfoxide (DMSO) organic solvent function monomer of metering being dissolved in metering; In another storage bottle, 1.0-5.0 gram of initiator (or initiator is together with auxiliary monomer of metering) is dissolved in the middle of the water of 1.5-2.0 litre.In the reactor, remaining initiator is dissolved among remaining water.Then, under 150-300 rev/min of whipped state, lead to industrial nitrogen 1 hour to described reactor.Subsequently, in the interlayer of reactor, make the solution temperature in reactor reach 70 ± 5 C by oil circulation method, and keep temperature, stirring and logical nitrogen.Then, the function monomer solution of above-mentioned outfit and initiator solution (or mixture solution of initiator and auxiliary monomer) are added in reactor respectively continuously with the speed of 0.5-1.0 ml/min with microprocessor pump drive simultaneously.After metered charge completes, continue to keep temperature, stirring and logical nitrogen 15-25 hour, obtain the initial product of diamino triazine functional group functional nanoparticle.Finally, by the method for dialysis (or micro-filtration), purifying is carried out to initial product, obtain the dispersion system of diamino triazine functional group functional nanoparticle in water.
Ask for an interview Fig. 1, the figure illustrates the Raolical polymerizable formula of the present embodiment.
Light scattering method measures display, the average particle size of a kind of diamino triazine functional group functional nanoparticle prepared by the present embodiment because of the control of formula for raw stock and reaction conditions be 30-150 nanometer.
The preparation of embodiment two 2-vinyl-4,6-diamino-1,3,5-triazines cross-linking copolymer nanoparticle
The present embodiment adopts the nanoparticle preparing diamino triazine functional group functionalization with 10 liters of reactors that embodiment one is identical.The present embodiment formula for raw stock lists in table 2.
The formula for raw stock of diamino triazine functional group functional nanoparticle prepared by table 2
| Material | Composition | Weight/volume |
| 2-vinyl-4,6-diamino-1,3,5-triazines | Function monomer | 50-100 gram |
| Trimethylolpropane trimethacrylate (TRIM) | Auxiliary monomer | 60-300 gram |
| Azo-bis-isobutyl cyanide | Radical initiator | 3.2-7.0 gram |
| Dimethyl sulfoxide (DMSO) | Organic solvent | 4.5-7.0 litre |
| Acetonitrile | Organic solvent | 2.5-5.0 litre |
In the reactor, function monomer, auxiliary monomer are dissolved among organic solvent or mixed organic solvents together with initiator.Then, under 50-150 rev/min of whipped state, lead to industrial nitrogen 1 hour to described reactor.Then, in the interlayer of reactor, make the solution temperature in reactor reach 65 ± 5 C by oil circulation method, and keep temperature, stirring and logical nitrogen 20-25 hour, obtain the initial product of diamino triazine functional group functional nanoparticle.Finally, by the method for dialysis (or micro-filtration), purifying is carried out to initial product, obtain the dispersion system of diamino triazine functional group functional nanoparticle in water.
Ask for an interview Fig. 2, the figure illustrates the crosslinked Raolical polymerizable formula of the present embodiment.
Light scattering method measures display, the average particle size of a kind of diamino triazine functional group functional nanoparticle prepared by the present embodiment because of the control of formula for raw stock and reaction conditions be 132-486 nanometer.
Embodiment three surface is with the preparation of the core-shell structure nanometer particle of diamino triazine functional group
The present embodiment adopts the core-shell structure nanometer particle preparing diamino triazine functional group functionalization with 10 liters of reactors that embodiment one is identical.The present embodiment formula for raw stock lists in table 3.The average particle size of polystyrene nanoparticle is 833 nanometers, and the solids content of its dispersion system in water is 3.8%(weight percent).
Table 3
| Material | Composition | Weight/volume |
| 2-vinyl-4,6-diamino-1,3,5-triazines | Function monomer | 65-110 gram |
| Dimethyl sulfoxide (DMSO) | Organic solvent | 0.6-1.0 litre |
| 2,2'-azo two (2-methyl-prop amidine) dihydrochloride (V-50) | Radical initiator | 1.5-3.0 gram |
| Deionized-distilled water | Water solvent | 6.0-8.0 litre |
| The dispersion system of polystyrene nanoparticle in water | Make the nano particle of core | 1.0-2.0 litre |
In the storage bottle of 2.5 liters, in the middle of the dimethyl sulfoxide (DMSO) function monomer of metering being dissolved in metering; In another storage bottle of 2.5 liters, in the middle of the water initiator of metering being dissolved in 1.5-2.0 litre.In reactor, add the dispersion system of polystyrene nanoparticle in water of remaining water and metering, and under 180-300 rev/min of whipped state, lead to industrial nitrogen 1 hour to reactor.Then, in the interlayer of reactor, make the solution temperature in reactor reach 70 ± 5 C by oil circulation method, and keep temperature, stirring and logical nitrogen.Then, the function monomer solution of above-mentioned outfit and initiator solution are added in reactor respectively continuously with the speed of 0.5-1.0 ml/min with microprocessor pump drive simultaneously.After metered charge completes, continue to keep temperature, stirring and logical nitrogen 15-25 hour, obtain the initial product of diamino triazine functional group functionalization core-shell structure nanometer particle.Finally, by the method for dialysis (or micro-filtration), purifying is carried out to initial product, obtain the dispersion system of diamino triazine functional group functionalization core-shell structure nanometer particle in water.
Light scattering method measures display, the average particle size of a kind of diamino triazine functional group functionalization core-shell structure nanometer particle prepared by the present embodiment because of the control of formula for raw stock and reaction conditions be 852-897 nanometer.
A kind of diamino triazine functional group functional nanoparticle absorption 5-Fluracil (5-FU) prepared by embodiment four the present invention
A kind of diamino triazine functional group functional nanoparticle absorption 5-FU that the present embodiment adopts embodiment one to prepare.
Ask for an interview Fig. 3, the figure illustrates described diamino triazine functional group functional nanoparticle and adsorb 5-FU by hydrogen bonded.
First the diamino triazine functional group functional nanoparticle latex of solids content to be 1.33% median size be 103 nanometers after preparing described purifying.Meanwhile, the 5-FU aqueous solution of 30 milligrams/deciliter is prepared.Then, shaking with 0.5 milliliter of 5-FU aqueous solution prepared containing diamino triazine functional group functional nanoparticle latex of at room temperature preparing 1.0 milliliters mixes 3 minutes.And then centrifugation is carried out 1 minute with 12000 revs/min to mixed solution.Finally, the solid after separation and liquid are collected respectively, obtain the aqueous solution that surface adsorption has diamino triazine functional group's functional nanoparticle of 5-FU molecule and 5-FU concentration to reduce.Ultraviolet spectroscopy shows the analytical results of 5-FU concentration in the collected aqueous solution: diamino triazine functional group functional nanoparticle is that every gram of diamino triazine functional group functional nanoparticle adsorbs 9.56 milligrams of 5-FU to the adsorption rate of 5-FU.
Ask for an interview Fig. 4, the figure illustrates the change of 5-FU concentration of aqueous solution before and after absorption and contrasting of 5-FU calibration curve.
Above-described embodiment use for illustrative purposes only.In addition, the present invention can also have other embodiment method.All employings are equal to the design, formula, proportioning, preparation, application, technical scheme etc. of replacement or equivalent transformation formation, are the protection domain of application claims.
Claims (9)
1. the preparation method of a diamino triazine functional group functional nanoparticle, the median size of described nanoparticle is 10-1000 nanometer, surface is with diamino triazine functional group, it is characterized in that the method is with 2-vinyl-4,6-diaminostilbene, 3,5-triazine is as function monomer, according to the principle of radical polymerization, adopt radical initiator cause described function monomer homopolymerization or with other auxiliary monomer copolymerization, comprise the following steps:
1) by described function monomer separately or be dissolved among organic solvent together with described auxiliary monomer;
2) by described radical initiator separately or among the mixture being dissolved in water or damping fluid or water and organic solvent together with described auxiliary monomer or organic solvent;
3) mixture or the organic solvent of water or damping fluid or water and organic solvent is added to the reactor with whipping appts, add simultaneously or do not add radical initiator, logical rare gas element under whipped state again, and temperature control is to 60-75 DEG C or provide rayed or apply sound wave;
4) by step 1) and step 2) solution prepared is metered among the reactor of step 3) respectively continuously or discontinuously with controlled speed;
5) after for some time is carried out in reaction, the initial product obtained is carried out purifying, finally the obtained latex containing diamino triazine functional group functional nanoparticle.
2. the preparation method of a diamino triazine functional group functional nanoparticle, the median size of described nanoparticle is 10-1000 nanometer, surface is with diamino triazine functional group, it is characterized in that the method is with 2-vinyl-4,6-diaminostilbene, 3,5-triazine is as function monomer, according to the principle of radical polymerization, adopt radical initiator cause described function monomer homopolymerization or with other auxiliary monomer copolymerization, comprise the following steps:
1) with in the reactor of whipping appts, under whipped state, temperature control is to 60-75 DEG C or provide rayed or apply sound wave, by described function monomer separately or among the mixture being dissolved in water or damping fluid or water and organic solvent together with described auxiliary monomer or organic solvent;
2) under whipped state, in described reactor, rare gas element is led to;
3) described radical initiator or its solution are joined in described reactor;
4) after for some time is carried out in reaction, the initial product obtained is carried out purifying, finally the obtained latex containing diamino triazine functional group functional nanoparticle.
3. the preparation method of a diamino triazine functional group functional nanoparticle, the median size of described nanoparticle is 10-1000 nanometer, surface is with diamino triazine functional group, it is characterized in that the method with the mixture of water or damping fluid or water and organic solvent or organic solvent for dispersion agent, preparation is containing the dispersion system of particle in advance; With 2-vinyl-4,6-diaminostilbene, 3,5-triazine as function monomer, according to the principle of radical polymerization, radical initiator is adopted to cause described function monomer homopolymerization or the method with other auxiliary monomer copolymerization, prepare with 2-vinyl-4,6-diaminostilbene, 3,5-triazine homopolymer or be shell with the multipolymer of auxiliary monomer, the core-shell structure nanometer particle that is core with the particle prepared in advance, comprise the following steps:
1) by described function monomer separately or be dissolved among organic solvent together with described auxiliary monomer;
2) by described radical initiator separately or among the mixture being dissolved in water or damping fluid or water and organic solvent together with described auxiliary monomer or organic solvent;
3) particle in the mixture or organic solvent being dispersed in water or damping fluid or water and organic solvent is added to the reactor with whipping appts, logical rare gas element under whipped state again, and temperature control is to 60-75 DEG C or provide rayed or apply sound wave;
4) by step 1) and step 2) solution prepared, be metered into continuously or discontinuously among described reactor with controlled speed respectively;
5), after for some time is carried out in reaction, the initial product obtained is carried out purifying, finally obtained containing the latex of surface with the core-shell structure nanometer particle of diamino triazine functional group.
4. the preparation method of diamino triazine functional group functional nanoparticle according to claim 1,2 or 3, is characterized in that: described radical initiator is single-component radical initiator, two component or multi-component radical initiator; Described auxiliary monomer is the mixture of one or more compounds, the molecule of each auxiliary monomer with one or two above can with the group of described function monomer generation radical copolymerization.
5. the preparation method of diamino triazine functional group functional nanoparticle according to claim 1,2 or 3, is characterized in that: described radical initiator is 2,2'-azo two (2-methyl-prop amidine) dihydrochloride, Diisopropyl azodicarboxylate.
6. the preparation method of diamino triazine functional group functional nanoparticle according to claim 1,2 or 3, is characterized in that: described auxiliary monomer is vinylbenzyltrimethyl ammonium chloride, trimethylolpropane trimethacrylate.
7. the preparation method of diamino triazine functional group functional nanoparticle according to claim 3, is characterized in that: the described particle prepared in advance is following one or more: macromolecule material particle, inorganic material particle, metallic material particles, composite material granular.
8. the using method of the diamino triazine functional group functional nanoparticle prepared according to claim 1,2 or 3, it is characterized in that: utilize the diamino triazine functional group of described nanoparticle surface to combine by forming strong hydrogen bonding, thus optionally absorption has the target compound of specified chemical the Nomenclature Composition and Structure of Complexes, comprises the following steps:
1) by described containing the latex of diamino triazine functional group functional nanoparticle and the solution of target compound or contain the mixture solution of target compound or dispersion system fully mixes;
2) the diamino triazine functional group functional nanoparticle being adsorbed with target compound is separated with above-mentioned mixed solution, obtains the nanoparticle being adsorbed with target compound and/or the liquid be purified.
9. using method according to claim 8, is characterized in that: described target compound comprises by forming hydrogen bonded, all molecules, ion, chemical structural units and the particle that adsorb to occur with diamino triazine functional group.
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| CN101824123A (en) * | 2009-12-23 | 2010-09-08 | 天津大学 | High-strength temperature-sensitive hydrogel as well as preparation method and application thereof |
| CN102675562A (en) * | 2012-05-16 | 2012-09-19 | 天津大学 | Polyethylene glycol macromonomer cross-linked high-strength hydrogel and photo-initiation radical polymerization process thereof |
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| CN101824123A (en) * | 2009-12-23 | 2010-09-08 | 天津大学 | High-strength temperature-sensitive hydrogel as well as preparation method and application thereof |
| CN102675562A (en) * | 2012-05-16 | 2012-09-19 | 天津大学 | Polyethylene glycol macromonomer cross-linked high-strength hydrogel and photo-initiation radical polymerization process thereof |
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| Robust MeO2MA/vinyl-4,6-diamino-1,3,5-triazine copolymer hydrogels-mediated reverse gene transfection and thermo-induced cell detachment;Lei Tang,et al.;《Biomaterials》;20101204;第32卷;第1943-1949页 * |
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