CN103044278B - Method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material - Google Patents
Method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material Download PDFInfo
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Abstract
The invention discloses a method for synthesizing levocarnitine by taking D-(-)-tartaric acid as raw material, and relates to a method for synthesizing levocarnitine. The method takes D-(-)-tartaric acid as raw material and comprises the following steps of: (I) synthesizing D-(-)-dibenzyl tartrate with benzyl alcohol by taking boric acid as a catalyst; (2) reducing the D-(-)-dibenzyl tartrate to obtain D-(-)-2,3,4-methyl trihydroxy benzene by taking sodium borohydride as a catalyst; (III) bromizing in a hydrogen bromide acetate solution to obtain D-(-)-3-hydroxy-2,4-methyl dibromo-benzene; (IV) introducing hydrogen and performing selective debromination hydrogenation to obtain D-(-)-3-hydroxyl-4-methyl bromobenzene by using a Pd/C catalyst; and (V) performing trimethylamine amination, hydrolysis and ion exchange to obtain levocarnitine. The process flow does not adopt a resolving agent and cyanide, the reaction conditions are mild, pollution is prevented, and the cost is low.
Description
Technical field
The present invention relates to a kind of method of synthetic levocarnitine, particularly relating to one, to utilize D-(-)-tartrate be the method for the synthetic levocarnitine of raw material.
Background technology
L-carnitine is named as " DL-carnitine chloride ".Be the Intramitochondrial unique carrier of lipid acid transporte to cells, thereby the most important function of L-carnitine is to promote the β-oxidation of lipid acid, reduces the content of serum cholesterol and triglyceride, improve the tolerance of body.In addition, L-carnitine also has: removing toxic substances acyl group residue, participate in branched-amino acid metabolic, regulate glycogenesis, promote the physiological actions such as ATP transhipment.2010 " People's Republic of China's the law of food safety " approval L-carnitine expands use range and usage quantity.
Only have at present the U.S., Italy, Japan and a handful of countries such as Chinese to produce, prices are rather stiff.Production method mainly contains two kinds, chemical synthesis and biological synthesis process.More than 5000 tons of the turnout 2009 of world market.Two kinds of methods respectively account for 50%.Northeast Pharmaceutical Group Co., Ltd. is largest production enterprise of China, adopts chemical synthesis, and take epoxy chloropropane as raw material, chirality SALEN-Co-catalyzer, obtains L-carnitine through amination, cyaniding, hydrolysis, and annual production is 2000 tons of left and right.There is catalyzer costliness, use toxic cyanide and split the difficulties such as second half product cannot utilize in technique, this is also the major cause why yielding poorly.
For the problem existing in L-carnitine chemosynthesis, solving poisonous sodium cyanide uses, chiral catalyst Recycling, adopt Non toxic technique synthetic l-carnitine, the synthesis technique of research reaction, selects suitable reagent, determines reaction conditions (temperature, proportioning, catalyzer, time etc.), to the problem in course of industrialization (heat transfer, rectifying, reactor, fluid flow, filter, dry, extraction, crystallization etc.) further investigation, for industrialization is layed foundation.This project achievement in research is that L-carnitine process for processing is deeply changed, a technological innovation of greenization, obtain high value-added product, improve economic benefit, the exploitation of project meets Sustainable development requirement, the novelty that possesses skills and high-tech content, have no report both at home and abroad, this achievement expection reaches domestically leading level.Enterprise product is upgraded, increased the benefit and benefit, be more conducive to health, the steady progression of L-carnitine manufacturing enterprise.China's L-carnitine production development and technical progress are had to important and far-reaching strategy and economic implications.
Summary of the invention
The object of the present invention is to provide one to utilize D-(-)-tartrate is the method for the synthetic levocarnitine of raw material, it is raw material that the method is utilized D-(-)-tartrate, through the synthetic levocarnitine of the techniques such as over-churning, reduction, bromination, hydrogenation, amination, hydrolysis, ion-exchange, in technique, do not use resolving agent and prussiate, reaction conditions gentleness, pollution-free, cost is low.
The object of the invention is to be achieved through the following technical solutions:
Utilizing D-(-)-tartrate is the method for the synthetic levocarnitine of raw material, the method adopts D-, and (-)-tartrate is chiral raw material, through over-churning, reduction, bromination, hydrogenation, amination, hydrolysis, the synthetic levocarnitine of ion exchange process, comprise following process: the first step, take D-(-)-tartrate as raw material, boric acid catalyst, with synthetic D-(-)-dibenzyl tartrate of phenylcarbinol; Second step, take sodium borohydride as catalyzer, to D-(-)-dibenzyl tartrate, reduction obtains D-(-)-2,3,4-trihydroxybenzene methyl esters; The 3rd step, in hydrogen bromide acetic acid solution, bromination obtains D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters; The 4th step, adopts Pd/C catalyzer, passes into hydrogen, product is carried out to selective debromination hydrogenation and obtain D-(-)-3-hydroxyl-4-bromobenzene methyl esters, and the 5th step, obtains levocarnitine through Trimethylamine 99 amination, hydrolysis, ion-exchange; Specifically comprise the synthetic of D-(-)-dibenzyl tartrate, D-(-)-2,3, synthesizing of 4-trihydroxybenzene methyl esters, D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters synthetic, D-(-)-3-hydroxyl-4-bromobenzene methyl esters synthetic, D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl synthetic, D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid synthetic.
Described D-(-)-tartrate that utilizes is the method for the synthetic levocarnitine of raw material, synthesizing of described D-(-)-dibenzyl tartrate: add D-(-)-tartrate in there-necked flask, boric acid, phenylcarbinol and toluene solution, stir, heat up, until after the whole dissolvings of solid, be warming up to backflow, react to the water yield in water trap and no longer increase, after being cooled to room temperature, reaction solution is poured in separating funnel, add isopyknic saturated NaHCO3 solution to be washed till without bubble formation, oil reservoir is used distilled water wash again, stratification, ester layer is dried with anhydrous magnesium sulfate, hold over night, filter, filtrate is poured into and in matrass, is carried out air distillation, remove toluene, phenylcarbinol is removed in underpressure distillation again, obtaining faint yellow oily matter is D-(-)-dibenzyl tartrate.
Described D-(-)-tartrate that utilizes is the method for the synthetic levocarnitine of raw material, described D-(-)-2, 3, synthesizing of 4-trihydroxybenzene methyl esters: get D-(-)-dibenzyl tartrate and be dissolved in tetrahydrofuran solution, join in there-necked flask, stir, under room temperature, add sodium borohydride in batches, being stirred to solid all dissolves, heat up, back flow reaction, TLC follows the tracks of and detects the disappearance of raw material point, be cooled to room temperature, solution is poured in separating funnel, with saturated sodium bicarbonate washing to without bubble formation, divide and remove organic layer, inorganic layer is extracted with ethyl acetate, merge organic layer, organic layer anhydrous magnesium sulfate drying, hold over night, filter, filtrate is carried out air distillation, except desolventizing, phenylcarbinol is removed in underpressure distillation again, obtain yellow oil D-(-)-2, 3, 4-trihydroxybenzene methyl esters.
Described D-(-)-tartrate that utilizes is the method for the synthetic levocarnitine of raw material, described D-(-)-3-hydroxyl-2, synthesizing of 4-dibromobenzene methyl esters: add D-(-)-2 in there-necked flask, 3, 4-trihydroxybenzene methyl esters and, hydrogen bromide acetic acid solution, in thermostat water bath, under room temperature, stir, after reaction stops, steaming desolventizes, residuum acetic acid ethyl dissolution, solution distilled water wash, stratification, organic layer anhydrous magnesium sulfate drying, filter, filtrate is carried out air distillation and is removed ethyl acetate, obtain Vandyke brown oily matter D-(-)-3-hydroxyl-2, 4-dibromobenzene methyl esters.
Described D-(-)-tartrate that utilizes is the method for the synthetic levocarnitine of raw material, synthesizing of described D-(-)-3-hydroxyl-4-bromobenzene methyl esters: get D-(-)-3-hydroxyl-2, 4-dibromobenzene methyl esters, ethyl acetate, acetic acid joins in there-necked flask, under stirring, add sodium acetate, anhydrous and Pd/C catalyzer, pass into hydrogen by hydrogen, reaction, inhale hydrogen speed slack-off, stopped reaction, filtering mixt, filter residue reclaims, process, catalyzer recycling, filtrate extremely generates without gas with saturated sodium bicarbonate solution washing, stratification, organic layer anhydrous magnesium sulfate drying, filter, steam except ethyl acetate, obtain brown liquid D-(-)-3-hydroxyl-4-bromobenzene methyl esters.
Described D-(-)-tartrate that utilizes is the method for the synthetic levocarnitine of raw material, synthesizing of described D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl: add D-(-)-3-hydroxyl-4-bromobenzene methyl esters and Trimethylamine 99 methanol solution in airtight there-necked flask, stir, be warming up to reaction, solution distillation, remove Trimethylamine 99 methanol solution, product crystallization, stir and filter with ether, obtain Vandyke brown D-(-)-3-hydroxyl-4-trimethylamine groups benzene methyl.
Described D-(-)-tartrate that utilizes is the method for the synthetic levocarnitine of raw material, synthesizing of described D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid: get D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl reflux in hydrochloric acid, be cooled to room temperature, the sodium hydroxide solution extraction that adds diethyl ether for solution, layering, remove upper solution, take off a layer solution distillation, steaming desolventizes, in residuum, add ethanol, heat up and stir rear suction filtration, filter cake washing with alcohol, merging filtrate and washing lotion vacuum concentration add water after dry, after dissolving completely, remove bromide anion by anionite-exchange resin, cross after post liquid concentrates and add ethanol, after fully mixing, reconcentration is removed ethanol, crystallization, vacuum-drying, obtain solid D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid.
Advantage of the present invention and effect are:
1. the present invention proposes one to utilize D-(-)-tartrate is the method for the synthetic levocarnitine of raw material, utilizing D-(-)-tartrate is raw material, through the production technology of the synthetic levocarnitine of the techniques such as over-churning, reduction, bromination, hydrogenation, amination, hydrolysis, ion-exchange, Technology is simple.
2. technical process is not used resolving agent and prussiate, reaction conditions gentleness, and pollution-free, cost is low.
Accompanying drawing explanation
Fig. 1 is technological line sketch;
Fig. 2 is D-(-)-dibenzyl tartrate IR spectrogram;
Fig. 3 is D-(-)-2,3,4-trihydroxybenzene methyl esters IR spectrogram;
Fig. 4 is D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters IR spectrogram;
Fig. 5 is D-(-)-3-hydroxyl-4-bromobenzene methyl esters IR spectrogram;
Fig. 6 is D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl IR spectrogram;
Fig. 7 is D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid IR spectrogram.
Note: Fig. 1-Fig. 7 of the present invention is the analysis schematic diagram of product state, the unintelligible understanding not affecting technical solution of the present invention of figure Chinese word or image.
Embodiment
Below in conjunction with embodiment, the present invention is described in detail.
Ultimate principle of the present invention:
(1) D-(-)-dibenzyl tartrate building-up reactions equation is as follows:
Tartaric two carboxyls of D-and phenylcarbinol generation esterification, in the mode of acyl-oxygen bond rupture, the hydrogen in hydroxyl and alcohol in carboxylic acid is combined into water molecules, and remainder is combined into ester.Mechanisms of esterification reaction is as follows:
(2) D-(-)-2,3,4-trihydroxy-butyric acid benzene methyl building-up reactions equation is as follows:
The ester that is connected with hydroxyl can optionally be reduced by sodium borohydride.First, sodium borohydride and hydroxyl form boron alkoxide sodium hydride intermediate.Due to the electronic effect that pushes away of alkoxyl group, B-H key is compared with sodium borohydride and there is stronger nucleophilicity, be corresponding alcohol by adjacent with it carboxyl reduction.Mechanism is as follows:
(3) D-(-)-2, the bromo-3-hydroxybutyrate benzene methyl of 4-bis-building-up reactions equation is as follows:
The acetum of hydrogen bromide is by two achiral hydroxyl brominations, and wherein this two hydroxyl all belongs to secondary alcohol, and reaction is generally undertaken by nucleophilic substitution SN1 mechanism, and mechanism is as follows:
(4) D-(-)-3-hydroxyl-4-bromo-butyric acid benzene methyl building-up reactions equation is as follows:
Select Pd/C catalyzer to carry out selective debromination hydrogenation reaction and belong to dehalogenation hydrogenolysis.D-(-)-3-hydroxyl-4-bromo-butyric acid benzene methyl is formed with organic metal complex through over hydrogenation addition mechanism and active metal catalyst, then reacts to obtain hydroformylation product solution by catalytic hydrogenation mechanism, and its mechanism is as follows:
(5) D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid benzene methyl building-up reactions equation is as follows:
The Trimethylamine 99 amination reaction of the bromo-3-hydroxybutyrate benzene methyl of D-(-)-2-is nucleophilic substitution reaction.Trimethylamine 99 has alkalescence and nucleophilicity, and the bromine of the bromo-3-hydroxybutyrate benzene methyl of D-(-)-2-is left away with the form of bromine negative ion, and Trimethylamine 99 is as nucleophilic reagent attack generation nucleophilic substitution.
(6) hydrolysis reaction equation is as follows:
D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid benzene methyl belongs to carboxylic acid derivative, can issue raw hydrolysis reaction in the effect of hydrochloric acid, generates corresponding carboxylic acid, and this hydrolysis reaction is typical nucleophilic substitution reaction.
Embodiment:
Synthesizing of D-(-)-dibenzyl tartrate:
In 500ml there-necked flask, add 45gD-(-)-tartrate, 2.25g boric acid, 90ml phenylcarbinol and 120ml toluene solution, toluene, for band aqua, stirs, heat up, until after solid all dissolves, be warming up to backflow, reflux water-dividing at 116 ℃, react to the water yield in water trap and no longer increase, a record point water yield.After being cooled to room temperature, reaction solution is poured in separating funnel, add isopyknic saturated NaHCO3 solution to be washed till without bubble formation, oil reservoir is used distilled water wash 2 ~ 3 times again, stratification, ester layer is dried with anhydrous magnesium sulfate, hold over night, filters, and filtrate is poured into and in matrass, carried out air distillation, remove toluene, phenylcarbinol is removed in underpressure distillation again, obtains the faint yellow oily matter of 92g, and product is D-(-)-dibenzyl tartrate.
D-(-)-2,3,4-trihydroxybenzene methyl esters synthetic:
Get 100gD-(-)-dibenzyl tartrate and be dissolved in 250ml tetrahydrofuran solution, join in 500ml there-necked flask, stir.Under room temperature, add sodium borohydride in batches, be stirred to solid and all dissolve, be warming up to 67 ℃, back flow reaction 30min, TLC follows the tracks of and detects the disappearance of raw material point.Be cooled to room temperature, solution is poured in separating funnel, use the washing of 300ml saturated sodium bicarbonate extremely without bubble formation, divide and remove organic layer, inorganic layer is extracted with ethyl acetate, and merges organic layer, organic layer anhydrous magnesium sulfate drying, hold over night, filters, filtrate is carried out air distillation, except desolventizing, then underpressure distillation removes phenylcarbinol, obtains 52.6g yellow oil D-(-)-2,3,4-trihydroxybenzene methyl esters.
D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters synthetic:
In 250ml there-necked flask, add 45gD-(-)-2,3,4-trihydroxybenzene methyl esters and 85ml, 34% hydrogen bromide acetic acid solution stir 24h under room temperature in thermostat water bath.After reaction stops, steaming desolventizes, residuum acetic acid ethyl dissolution, distilled water wash twice for solution, stratification, organic layer anhydrous magnesium sulfate drying, filter, filtrate is carried out air distillation and is removed ethyl acetate, obtains 43g Vandyke brown oily matter D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters.
Synthesizing of D-(-)-3-hydroxyl-4-bromobenzene methyl esters:
Get 30.6gD-(-)-3-hydroxyl-2, 4-dibromobenzene methyl esters, 240ml ethyl acetate, 24ml acetic acid joins in 500ml there-necked flask, under stirring, add 24g sodium acetate, anhydrous and 1.5g 5% Pd/C catalyzer, pressure is 1atm, 65 ℃ of temperature of reaction, pass into hydrogen by hydrogen, reaction 1h, inhale hydrogen speed slack-off, stopped reaction, filtering mixt, filter residue reclaims, process, catalyzer recycling, filtrate extremely generates without gas with saturated sodium bicarbonate solution washing, stratification, organic layer anhydrous magnesium sulfate drying, filter, steam except ethyl acetate, obtain 18.4g brown liquid D-(-)-3-hydroxyl-4-bromobenzene methyl esters.
Synthesizing of D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl:
In airtight there-necked flask, add 18gD-(-)-3-hydroxyl-4-bromobenzene methyl esters and 31ml, 33% Trimethylamine 99 methanol solution, stir, be warming up to 60 ℃, reaction 20h.Solution distillation, removes Trimethylamine 99 methanol solution, and product crystallization is stirred and filtered with ether, obtains 21.1gD-(-)-3-hydroxyl-4-trimethylamine groups benzene methyl, is Vandyke brown.
Synthesizing of D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid:
Get 21gD-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl reflux 3h in 100ml 2mol/L hydrochloric acid, be cooled to room temperature, solution is adjusted to pH2 with 2mol/L sodium hydroxide solution.The extraction that adds diethyl ether, layering, removes upper solution, take off a layer solution distillation, steaming desolventizes, and adds 50ml ethanol in residuum, be warming up to 50 ℃, suction filtration after stirring 30min, ethanol for filter cake (20ml × 2) washing, merging filtrate and washing lotion vacuum concentration add water 100mL after dry, after dissolving completely, remove bromide anion by anionite-exchange resin, cross after post liquid concentrates and add 50mL ethanol, after fully mixing, reconcentration is removed ethanol, crystallization, vacuum-drying, obtains 7.2g solid.
D-(-)-dibenzyl tartrate infrared spectrum and analysis:
3487cm-1 place absorption peak, is alcohol-OH stretching vibration peak, and 1094cm-1 is the stretching vibration absorption peak of C-O in alcohol; 1750 cm-1 are the stretching vibration of C=O in ester, and 1213cm-1 is the stretching vibration peak of C-O in ester, have illustrated that ester bond exists; 1602cm-1,1513cm-1,1494 cm-1 and 1453cm-1 are the key band of phenyl ring skeleton, and the absorption peak at 3027cm-1 place is C-H stretching vibration peak on phenyl ring, show synthetic D-(-)-dibenzyl tartrate.
D-(-)-2,3,4-trihydroxybenzene methyl esters infrared spectrum and analysis:
3424cm-1 place absorption peak, is alcohol-OH stretching vibration peak, and 1105cm-1 is the stretching vibration absorption peak of C-O in alcohol, grow; 1743 cm-1 are the stretching vibration of C=O in ester, and 1213cm-1 is the stretching vibration peak of C-O in ester, have illustrated that ester bond exists; 3031cm-1 place is the stretching vibration peak of methylene radical C-H; 1634cm-1,1583cm-1,1496 cm-1 and 1454cm-1 are the key band of phenyl ring skeleton, and the absorption peak at 3031cm-1 place is C-H stretching vibration peak on phenyl ring.
Detect and learn that dibenzyl tartrate point disappears by TLC, be converted into novel substance, and exist from the known ester group that still has of infrared spectrum, therefore infer to generate D-(-)-2,3 4-trihydroxy-butyric acid benzene methyl.
D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters infrared spectrum and analysis:
1752 cm-1 are the stretching vibration of C=O in ester, and 1226cm-1 is the stretching vibration peak of C-O in ester, have illustrated that ester bond exists; 2924cm-1 place is the stretching vibration peak of methylene radical C-H; 1583cm-1,1513cm-1,1495 cm-1 and 1454cm-1 are the key band of phenyl ring skeleton, and the absorption peak at 3029cm-1 place is C-H stretching vibration peak on phenyl ring; 3441cm-1 place absorption peak, is alcohol-OH stretching vibration peak, and 1030cm-1 is the stretching vibration absorption peak of C-O in alcohol, dies down; 547cm-1 place is C-Br stretching vibration peak, shows to occur bromo-reaction.
D-(-)-3-hydroxyl-4-bromobenzene methyl esters infrared spectrum and analysis:
3445cm-1 place absorption peak is alcohol-OH stretching vibration peak; 1751cm-1 is the stretching vibration of C=O in ester, and 1226cm-1 is the stretching vibration peak of C-O in ester, has illustrated that ester bond still exists; 1608cm-1,1561cm-1,1494 cm-1 and 1453cm-1 are the key band of phenyl ring skeleton, and the absorption peak at 3029cm-1 place is C-H stretching vibration peak on phenyl ring; 547cm-1 place is C-Br stretching vibration peak, dies down, because part bromine is by hydrogenolysis.
D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl infrared spectrum and analysis:
3424cm-1 place absorption peak is alcohol-OH stretching vibration peak; 1752 cm-1 are the stretching vibration of C=O in ester, and 1221cm-1 is the stretching vibration peak of C-O in ester, have illustrated that ester bond exists; 1631cm-1,1488 cm-1 and 1457cm-1 are the key band of phenyl ring skeleton; 2924cm-1 place is the stretching vibration peak of methylene radical C-H; 2863cm-1 place is the stretching vibration peak of methyl C-H, and the stretching vibration peak that 1414cm-1 place is C-N illustrates and has Trimethylamine 99; C-Br stretching vibration peak disappears, and shows that bromine is replaced by Trimethylamine 99.
D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid infrared spectrum and analysis:
3460cm-1 place absorption peak is alcohol-OH stretching vibration peak; 1601 cm-1 are the stretching vibration of C=O in carboxylic acid, and 1229cm-1 is the stretching vibration peak of C-O in acid, have illustrated that carboxylic acid exists; 2908cm-1 place is the stretching vibration peak of methylene radical C-H; 2950cm-1 place is the stretching vibration peak of methyl C-H, and the stretching vibration peak that 1413cm-1 place is C-N illustrates and has Trimethylamine 99.
Claims (7)
1. utilizing D-(-)-tartrate is the method for the synthetic levocarnitine of raw material, it is characterized in that, the method adopts D-, and (-)-tartrate is chiral raw material, through over-churning, reduction, bromination, hydrogenation, amination, hydrolysis, the synthetic levocarnitine of ion exchange process, comprise following process: the first step, take D-(-)-tartrate as raw material, boric acid catalyst, with synthetic D-(-)-dibenzyl tartrate of phenylcarbinol; Second step, take sodium borohydride as reductive agent, to D-(-)-dibenzyl tartrate, reduction obtains D-(-)-2,3,4-trihydroxybenzene methyl esters; The 3rd step, in hydrogen bromide acetic acid solution, bromination obtains D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters; The 4th step, adopts Pd/C catalyzer, passes into hydrogen, product is carried out to selective debromination hydrogenation and obtain D-(-)-3-hydroxyl-4-bromobenzene methyl esters, and the 5th step, obtains levocarnitine through Trimethylamine 99 amination, hydrolysis, ion-exchange; Specifically comprise the synthetic of D-(-)-dibenzyl tartrate, D-(-)-2,3, synthesizing of 4-trihydroxybenzene methyl esters, D-(-)-3-hydroxyl-2,4-dibromobenzene methyl esters synthetic, D-(-)-3-hydroxyl-4-bromobenzene methyl esters synthetic, D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl synthetic, D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid synthetic.
2. the D-of utilization according to claim 1 (-)-tartrate is the method for the synthetic levocarnitine of raw material, it is characterized in that, synthesizing of described D-(-)-dibenzyl tartrate: add D-(-)-tartrate in there-necked flask, boric acid, phenylcarbinol and toluene solution, stir, heat up, until after the whole dissolvings of solid, be warming up to backflow, react to the water yield in water trap and no longer increase, after being cooled to room temperature, reaction solution is poured in separating funnel, add isopyknic saturated NaHCO3 solution to be washed till without bubble formation, oil reservoir is used distilled water wash again, stratification, ester layer is dried with anhydrous magnesium sulfate, hold over night, filter, filtrate is poured into and in matrass, is carried out air distillation, remove toluene, phenylcarbinol is removed in underpressure distillation again, obtaining faint yellow oily matter is D-(-)-dibenzyl tartrate.
3. the D-of utilization according to claim 1 (-)-tartrate is the method for the synthetic levocarnitine of raw material, it is characterized in that, described D-(-)-2, 3, synthesizing of 4-trihydroxybenzene methyl esters: get D-(-)-dibenzyl tartrate and be dissolved in tetrahydrofuran solution, join in there-necked flask, stir, under room temperature, add sodium borohydride in batches, being stirred to solid all dissolves, heat up, back flow reaction, TLC follows the tracks of and detects the disappearance of raw material point, be cooled to room temperature, solution is poured in separating funnel, with saturated sodium bicarbonate washing to without bubble formation, divide and remove organic layer, inorganic layer is extracted with ethyl acetate, merge organic layer, organic layer anhydrous magnesium sulfate drying, hold over night, filter, filtrate is carried out air distillation, except desolventizing, phenylcarbinol is removed in underpressure distillation again, obtain yellow oil D-(-)-2, 3, 4-trihydroxybenzene methyl esters.
4. the D-of utilization according to claim 1 (-)-tartrate is the method for the synthetic levocarnitine of raw material, it is characterized in that, described D-(-)-3-hydroxyl-2, synthesizing of 4-dibromobenzene methyl esters: add D-(-)-2 in there-necked flask, 3, 4-trihydroxybenzene methyl esters and, hydrogen bromide acetic acid solution, in thermostat water bath, under room temperature, stir, after reaction stops, steaming desolventizes, residuum acetic acid ethyl dissolution, solution distilled water wash, stratification, organic layer anhydrous magnesium sulfate drying, filter, filtrate is carried out air distillation and is removed ethyl acetate, obtain Vandyke brown oily matter D-(-)-3-hydroxyl-2, 4-dibromobenzene methyl esters.
5. the D-of utilization according to claim 1 (-)-tartrate is the method for the synthetic levocarnitine of raw material, it is characterized in that, synthesizing of described D-(-)-3-hydroxyl-4-bromobenzene methyl esters: get D-(-)-3-hydroxyl-2, 4-dibromobenzene methyl esters, ethyl acetate, acetic acid joins in there-necked flask, under stirring, add sodium acetate, anhydrous and Pd/C catalyzer, pass into hydrogen by hydrogen, reaction, inhale hydrogen speed slack-off, stopped reaction, filtering mixt, filter residue reclaims, process, catalyzer recycling, filtrate extremely generates without gas with saturated sodium bicarbonate solution washing, stratification, organic layer anhydrous magnesium sulfate drying, filter, steam except ethyl acetate, obtain brown liquid D-(-)-3-hydroxyl-4-bromobenzene methyl esters.
6. the D-of utilization according to claim 1 (-)-tartrate is the method for the synthetic levocarnitine of raw material, it is characterized in that, synthesizing of described D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl: add D-(-)-3-hydroxyl-4-bromobenzene methyl esters and Trimethylamine 99 methanol solution in airtight there-necked flask, stir, be warming up to reaction, solution distillation, remove Trimethylamine 99 methanol solution, product crystallization, stir and filter with ether, obtain Vandyke brown D-(-)-3-hydroxyl-4-trimethylamine groups benzene methyl.
7. the D-of utilization according to claim 1 (-)-tartrate is the method for the synthetic levocarnitine of raw material, it is characterized in that, synthesizing of described D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid: get D-(-)-bromination-3-hydroxyl-4-trimethylamine groups benzene methyl reflux in hydrochloric acid, be cooled to room temperature, the sodium hydroxide solution extraction that adds diethyl ether for solution, layering, remove upper solution, take off a layer solution distillation, steaming desolventizes, in residuum, add ethanol, heat up and stir rear suction filtration, filter cake washing with alcohol, merging filtrate and washing lotion vacuum concentration add water after dry, after dissolving completely, remove bromide anion by anionite-exchange resin, cross after post liquid concentrates and add ethanol, after fully mixing, reconcentration is removed ethanol, crystallization, vacuum-drying, obtain solid D-(-)-3-hydroxyl-4-trimethylamine groups butyric acid.
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| RU2789509C1 (en) * | 2019-03-06 | 2023-02-06 | Вайсориг Текнолоджис Пте. Лимитед | APPLICATION OF A COMPOUND BASED ON γ-QUATERNARY AMMONIUM BUTYRATE IN OBTAINING A FEED ADDITIVE FOR ANIMALS |
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| AU2019432401B9 (en) * | 2019-03-06 | 2023-09-28 | Anipha Technologies Pty Ltd | USE OF γ-QUATERNARY AMMONIUM BUTYRATE COMPOUND IN PREPARATION OF ANIMAL FEED ADDITIVE |
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| RU2789509C1 (en) * | 2019-03-06 | 2023-02-06 | Вайсориг Текнолоджис Пте. Лимитед | APPLICATION OF A COMPOUND BASED ON γ-QUATERNARY AMMONIUM BUTYRATE IN OBTAINING A FEED ADDITIVE FOR ANIMALS |
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