CN103037940B - New application - Google Patents
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- CN103037940B CN103037940B CN201180015772.7A CN201180015772A CN103037940B CN 103037940 B CN103037940 B CN 103037940B CN 201180015772 A CN201180015772 A CN 201180015772A CN 103037940 B CN103037940 B CN 103037940B
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- Prior art keywords
- zinc
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- sddbs
- mottle
- compositions
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- 239000000203 mixture Substances 0.000 claims abstract description 38
- HFQQZARZPUDIFP-UHFFFAOYSA-M sodium;2-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O HFQQZARZPUDIFP-UHFFFAOYSA-M 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 9
- 210000000214 Mouth Anatomy 0.000 claims description 7
- PTFCDOFLOPIGGS-UHFFFAOYSA-N zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 7
- 239000000606 toothpaste Substances 0.000 claims description 6
- 150000003751 zinc Chemical class 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 229940034610 Toothpaste Drugs 0.000 claims description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L Zinc chloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L Zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 239000011592 zinc chloride Substances 0.000 claims description 4
- 235000005074 zinc chloride Nutrition 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 229960001763 zinc sulfate Drugs 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- 229940046282 Zinc Drugs 0.000 claims description 3
- 229940091251 Zinc Supplements Drugs 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- KOYYEPZTIWTHDY-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;zinc;dihydrate Chemical compound O.O.[Zn].[Zn].[Zn].OC(=O)CC(O)(C(O)=O)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O KOYYEPZTIWTHDY-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N Malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229940068475 ZINC CITRATE Drugs 0.000 claims description 2
- 229940050168 ZINC LACTATE Drugs 0.000 claims description 2
- 229960000314 Zinc Acetate Drugs 0.000 claims description 2
- 229960000306 Zinc Gluconate Drugs 0.000 claims description 2
- 229960001296 Zinc Oxide Drugs 0.000 claims description 2
- DJWUNCQRNNEAKC-UHFFFAOYSA-L Zinc acetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O DJWUNCQRNNEAKC-UHFFFAOYSA-L 0.000 claims description 2
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 2
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H Zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 2
- LILHXQCLSOZSRO-UHFFFAOYSA-J dizinc;oxozinc;dicarbonate;tetrahydrate Chemical compound O.O.O.O.[Zn+2].[Zn+2].[Zn]=O.[Zn]=O.[Zn]=O.[O-]C([O-])=O.[O-]C([O-])=O LILHXQCLSOZSRO-UHFFFAOYSA-J 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N fumaric acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- 229940098895 maleic acid Drugs 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 229940099690 malic acid Drugs 0.000 claims description 2
- 239000004246 zinc acetate Substances 0.000 claims description 2
- 235000013904 zinc acetate Nutrition 0.000 claims description 2
- 239000011667 zinc carbonate Substances 0.000 claims description 2
- 235000004416 zinc carbonate Nutrition 0.000 claims description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
- 229940043825 zinc carbonate Drugs 0.000 claims description 2
- 229960001939 zinc chloride Drugs 0.000 claims description 2
- 239000011746 zinc citrate Substances 0.000 claims description 2
- 235000006076 zinc citrate Nutrition 0.000 claims description 2
- 239000011670 zinc gluconate Substances 0.000 claims description 2
- 235000011478 zinc gluconate Nutrition 0.000 claims description 2
- 239000011576 zinc lactate Substances 0.000 claims description 2
- 235000000193 zinc lactate Nutrition 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 2
- 229940077935 zinc phosphate Drugs 0.000 claims description 2
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2R,3R)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- PZXFWBWBWODQCS-UHFFFAOYSA-L zinc;2-carboxyphenolate Chemical compound [Zn+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O PZXFWBWBWODQCS-UHFFFAOYSA-L 0.000 claims 1
- 210000000515 Tooth Anatomy 0.000 abstract description 11
- 230000002265 prevention Effects 0.000 abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 241001122767 Theaceae Species 0.000 description 8
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 description 7
- 235000019832 sodium triphosphate Nutrition 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 5
- 210000003298 Dental Enamel Anatomy 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 4
- 238000005497 microtitration Methods 0.000 description 4
- 230000000844 anti-bacterial Effects 0.000 description 3
- 230000003110 anti-inflammatory Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 230000002087 whitening Effects 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 2
- 229960001927 Cetylpyridinium Chloride Drugs 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M Cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- 210000003296 Saliva Anatomy 0.000 description 2
- 208000004509 Tooth Discoloration Diseases 0.000 description 2
- 206010044032 Tooth discolouration Diseases 0.000 description 2
- 238000005296 abrasive Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003213 activating Effects 0.000 description 2
- 230000002882 anti-plaque Effects 0.000 description 2
- 230000001580 bacterial Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002708 enhancing Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 230000036367 tooth discoloration Effects 0.000 description 2
- 200000000019 wound Diseases 0.000 description 2
- CSAVDNHVPJNKTC-UHFFFAOYSA-N 5-methyl-2-propan-2-ylcyclohexan-1-ol;5-methyl-2-propan-2-ylphenol;2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane Chemical compound CC(C)C1CCC(C)CC1O.CC(C)C1=CC=C(C)C=C1O.C1CC2CCC1(C)OC2(C)C CSAVDNHVPJNKTC-UHFFFAOYSA-N 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 229940112822 Chewing Gum Drugs 0.000 description 1
- 229960003260 Chlorhexidine Drugs 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002925 Dental Caries Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Exidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 210000004195 Gingiva Anatomy 0.000 description 1
- 229940076522 Listerine Drugs 0.000 description 1
- 229940051866 Mouthwash Drugs 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 229940033123 Tannic Acid Drugs 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N Tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229910001573 adamantine Inorganic materials 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003479 dental cement Substances 0.000 description 1
- 230000001419 dependent Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 230000001089 mineralizing Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 230000003239 periodontal Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000002335 preservative Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive Effects 0.000 description 1
- 230000000069 prophylaxis Effects 0.000 description 1
- 230000000717 retained Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Abstract
The present invention relates to the purposes that dodecylbenzene sodium sulfonate (SDDBS) is adapted to assist in the mottle of prevention or removing natural teeth and dental case surface deposition, and the oral care composition comprising SDDBS for this purposes.
Description
The present invention relates to dodecylbenzene sodium sulfonate (SDDBS) be used for resisting (i.e. help prevention or remove) natural teeth and tooth
The purposes of the mottle of dummy surface deposition, and the oral care composition comprising SDDBS for this purposes.Suitably group
Compound includes collutory and dentifrice composition.
Some factors make tooth discoloration, but be sure of three principal elements: i) dental surface forms plaque and tartar substrate,
Then (entrap) mottle, ii are retained down) in tooth forming process, taken in some drugs, and iii) formed at enamel
Cheng Zhong, due to oral wounds, then blood stains thing penetrates into the mineralizing surface of tooth and makes its variable color.Present invention primarily contemplates tooth discoloration
First factor or reason, the i.e. natural sediment mottle on tooth.
Have been developed for OTC (over-the-counter) brightener for tooth, it is desirable to provide recover surface trapped substance and cause the adamantine light of variable color
Many cosmetic advantages in pool.Although all of collutory and dentifrice composition all comprise some abluents and polishing agent, some teeth
Surface deposits may become difficult to process, and can not be completely removed by these reagent under normal usage.These preparations
Be likely to be not use completely remove due to be excessively exposed to coloring agent formed mottle and variable color amount required for reagent use
Amount and type are prepared.Such as, smoker generally develop into enamel decolouring because exhalation smoke from cigarette in tar and
Particle deposition is on tooth.Further, abundance of food can make enamel play mottle and decolouring, and Folium Camelliae sinensis is the example of a kind of beverage, its
Tannic acid in middle tea is deposited on enamel.Some medicinal reagents can cause mottle or variable color via retaining, although this is not
The most common reason of this kind of mottle.
The mode that the most commonly used three kinds of enamels brighten.They be all based on use abrasive, use oxidant or
Hydrolysate is utilized to decompose coloring thing, such as enzyme based products.
SDDBS is a kind of for many oral cavities and the anion surfactant of personal care product.
The present invention has been based on the discovery that SDDBS has antiplaque activity.In particular, it was found that SDDBS is prevented by it
The ability suppression mottle that food mottle absorbs on model surface is formed.In addition, SDDBS is shown to remove in vitro color
Speckle.
Therefore, at first aspect, the present invention provides a kind of for resisting (i.e. contribute to prevention or remove) dental surface (ratio
Such as natural teeth surface or dental case surface) the oral care composition of mottle, wherein said composition comprises SDDBS.
At second aspect, the present invention provides SDDBS preparing the oral care composition for anti-dental surface mottle
In purposes.
At the 3rd aspect, the present invention provides a kind of method for anti-dental surface mottle, and described method includes to tooth
Tooth surface uses the oral care composition of the SDDBS comprising effective dose.
Suitably, amount is total composition weight the 0.1% to 10.0% of SDDBS, such as 0.2% to 5.0% with
On, or be more suitably 0.25% to 2.0%.
It is from Pilot Chemical Company, 2744 East Kemper for the SDDBS of the present invention
Rd.Cincinnati, Ohio 45241 is obtainable with trade name Calsoft F90.
The oral care composition of the present invention can comprise one or more activity being generally used for oral care composition
Agent, such as fluoride source, desensitizer, anti-plaque agent；Anticalculus agent, halitosis agent (oral malodour agent), antiinflammatory or
The mixture that at least a part of which is two kinds.Such reagent can be included to provide the level of expectation therapeutic effect.
Suitably, the compositions of the present invention comprises zinc ion source further.Zinc ion has antibacterial properties, is adapted to assist in pre-
Prevent, suppress and/or treat oral hygiene disease that is bacterial present in oral cavity or that increase the weight of, including periodontal (gingiva) disease
Disease, dental caries, halitosis, dental plaque and tartar.
Suitably, zinc ion source, when the zinc part as corresponding salt defines, amount is total composition weight
0.01% to 2.50%, such as 0.04% to 0.70%.
Suitably, zinc ion source is zinc salt, such as zinc chloride, zinc citrate, zinc acetate, zinc sulfate, zinc gluconate, water
Poplar acid zinc, zinc lactate, MALEIC ACID, ZINC SALT, malic acid zinc, zinc tartrate, zinc carbonate, zinc phosphate, zinc oxide or zinc sulfate.Additionally
Zinc salt is described in United States Patent (USP) 4,022,880 (Vinson et al.).
A kind of preferably zinc salt is zinc chloride.
Suitably, the compositions of the present invention comprises 4-isopropyl-3-methylphenol (IPMP) further.IPMP has antibacterial
Anti-inflammatory activity, is adapted to assist in prevention, suppresses and/or treats oral hygiene disease that is bacterial present in oral cavity or that increase the weight of
Sick.
Suitably, amount is total composition weight the 0.005% to 1.00% of IPMP, such as 0.01% to 0.20%
Or 0.05% to 0.10%.
The oral care composition of the combination comprising IPMP, zinc salt and SDDBS demonstrates the antibacterial activity of enhancing, Yi Jiyou
Anti-inflammatory activity and resisted mottle benefit.
The oral care composition of the present invention is normally configured to toothpaste, spray, collutory, rinse liquid
(mouthrinse), gel, lozenge, chewing gum, tablet, pastille, instant powder (instant powders), refreshing tablets
(oral strips), buccal patch, wound dressing and dental cement.
In one embodiment, the compositions of the present invention is dentifrice composition, and more suitably, it can connect for comprising oral cavity
The carrier being subject to or the mouthrinse composition of excipient.
The oral care composition of the present invention should comprise other reagent preparation, lives in such as abrasive, thickening agent, surface
Property agent, wetting agent, flavoring agent, sweeting agent, opacifier or coloring agent, preservative and water, selected from the mouth for such purpose
In the hygiene composition of chamber normally used those.
Suitably oral care active agents and oral cavity acceptable carrier or excipient (the most above-mentioned reagent preparation) is described in
Such as in US 2007/0053849 (Procter & Gamble).
Compositions according to the present invention can be prepared by mixing the composition of appropriate relative amounts with order the most easily,
If it is necessary, regulation pH is to obtain final desired value.
When the form that compositions is toothpaste, it is be applicable to being contained in such as laminated tube commonly used in the art or pump and therefrom
Distribution.
Now, by following embodiment and data, the present invention is described.
Embodiment
1. hydroxyapatite mottle prophylaxis model (HASP)
Method
With the most non-be excited people's saliva (whole unstimulated human saliva) (100 μ l/ hole) 37 DEG C/
The microtitration plate of 96 hole hydroxyapatite coatings is processed under 100rpm.After 1 hour, by any to remove for the washing of described plate
Unconjugated component, by every kind of 200 μ l test activating agent and positive and negative control (respectively 5% Sodium triphosphate (STP) and
Water) transfer to the plate of each row, and plate is put back in incubator.After 10 min, plate is cleaned again, and by applying 200 μ
The newly picked and processed tea leaves solution (deionized water of 1 tea bag (PG tips)/50ml) of l makes plate play mottle.After again cultivating 10 minutes, move
Except tea, and wash plate.Finally, by using the 2.5M citric acid/hole of 200 μ l to make the mottle desorption of combination.Minimum 12 little
Time after, the tea/citric acid solution of 180 μ l is transferred to clean, normal (not having HA to be coated with) 96 hole microtitration plate, and
Measure under 405nm and absorb.
2. the dark brown speckle of hydroxyapatite removes model (HATSR)
Method
96 hole hydroxy-apatites are processed with the tea/hole (deionized water of 1 tea bag (PG Tips)/50ml) of 100 μ l aliquots
The microtitration plate of stone coating, and under 37 DEG C/100rpm, cultivate described plate.After 10 min, plate is washed with deionized water
Wash, and be dried overnight at 37 DEG C.Test activating agent (200 μ l/ hole) is joined the plate of tea coating of each column with positive and cloudy
Property comparison (respectively 5% Sodium triphosphate (STP) and water), and plate is put back to incubator.After 10 min, plate is washed again
Wash, by using the 2.5M citric acid/hole of 200 μ l to make the mottle desorption of combination.After minimum 12 hours, by 180 μ l's
Tea/citric acid solution transfers to clean, normal (not having HA to be coated with) 96 hole microtitration plate, and measures absorption under 405nm.
Result
3.1. solution
All solution are all in 7 times tests of pH.
Fig. 1. in HASP model (n=8), concentration range 0.1%10% time, the mottle preventive dose of the SDDBS of test
Reaction.
Conclusion
The result display SDDBS prevention food mottle of Fig. 1 absorbs on HASP model oral surfaces.All of SDDBS is dense
Degree is the most statistically better than water negative control, except 0.1% (it is only that orientation is better than), but neither one and positive control
STP (a kind of known stainblocker used in many whitening toothpastes) is the most effective.
Fig. 2. in HASP model (n=8), under concentration range 0.1%-10%, the mottle of the SDDBS of test removes dosage
Reaction.
Conclusion
The result of the HATSR model test in Fig. 2 shows that SDDBS removes mottle with dosage-dependent manner.All of
SDDBS concentration is the most statistically better than water negative control, except concentration 0.125%, but neither one and positive control STP (
A kind of known stainblocker used in many whitening toothpastes) the most effective.
Fig. 3. in HASP model (n=8), SDDBS/SLS's combination (total surfactant level: 1%) of test
Mottle prevention data.
Conclusion
The result of the HASP model test of Fig. 3 shows that, under equivalent concentration, SDDBS is statistically better than lauryl sulphate acid
Sodium (SLS).
Keeping the constant concentration of surfactant 1%, it is effective that the combination of SDDBS and SLS is shown without 1%SDDBS,
But still better than single SLS.The process of all SDDBS of comprising is better than water, but not with positive control STP (in many
A kind of known stainblocker used in whitening toothpaste) the most effective.
Embodiment preparation
In HASP (Fig. 4) and HATSR (Fig. 5) model, also evaluate for a large amount of commercially available obtainable products and comprise SDDBS
Mouthwash formulations.
Fig. 4. in HASP model (n=8), the test preparation comprising 0.5%SDDBS of test obtains relative to commercially available
The mottle prevention data of product.
Fig. 5. in HASP model (n=8), the test preparation comprising 0.5%SDDBS of test obtains relative to commercially available
The mottle of product removes data.
Conclusion
Prevent deposition and the removing aspect of food mottle in vitro, comprise all 3 kinds of test collutorys of 0.5%SDDBS
(MW1, MW2 and MW3) all demonstrates and is statistically better than commercially available obtainable product.With commercially available prod (except Listerine
Outside (Original and Total Care)) different, these preparations do not comprise can be in conjunction with mottle chromophore and enhancing mottle
Cationic antimicrobial agent, such as cetylpyridinium chloride (CPC) and chlorhexidine.
MW embodiment preparation 1-3 (as shown in above-mentioned Figure 4 and 5)
Claims (8)
1. dodecylbenzene sodium sulfonate (SDDBS) protects for the oral cavity of anti-dental surface mottle in preparation as sole active agent
Purposes in reason compositions.
Purposes the most according to claim 1, wherein said compositions comprises zinc ion source further.
Purposes the most according to claim 2, wherein said zinc ion source selected from zinc chloride, zinc citrate, zinc acetate, zinc sulfate,
Zinc gluconate, zinc salicylate, zinc lactate, malic acid zinc, MALEIC ACID, ZINC SALT, zinc tartrate, zinc carbonate, zinc phosphate, zinc oxide or
Zinc sulfate.
Purposes the most according to claim 3, wherein said zinc ion source is zinc chloride.
5., according to the purposes any one of Claims 1-4, wherein said compositions comprises 4-isopropyl-3-methyl further
Phenol (IPMP).
6., according to the purposes any one of Claims 1-4, wherein said compositions is collutory or toothpaste.
7., according to the purposes any one of Claims 1-4, wherein said compositions is collutory.
8., for a method for anti-dental surface mottle, described method includes using to dental surface comprising effective dose
The oral care composition of SDDBS, wherein SDDBS is used as the sole active agent for anti-dental surface mottle, Qi Zhongsuo
Method of stating is for non-treatment purpose.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1004981.5A GB201004981D0 (en) | 2010-03-24 | 2010-03-24 | Novel use |
| GB1004981.5 | 2010-03-24 | ||
| PCT/EP2011/054291 WO2011117216A2 (en) | 2010-03-24 | 2011-03-22 | Novel use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103037940A CN103037940A (en) | 2013-04-10 |
| CN103037940B true CN103037940B (en) | 2016-11-30 |
Family
ID=
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0870492A1 (en) * | 1997-04-11 | 1998-10-14 | Carter-Wallace, Inc. | Oral composition comprising aluminium hydroxide, silica and an anionic surfactant |
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0870492A1 (en) * | 1997-04-11 | 1998-10-14 | Carter-Wallace, Inc. | Oral composition comprising aluminium hydroxide, silica and an anionic surfactant |
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Granted publication date: 20161130 Termination date: 20170322 |