CN103007432B - Integrated device for modulating and detecting brain functions - Google Patents
Integrated device for modulating and detecting brain functions Download PDFInfo
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- CN103007432B CN103007432B CN201210560369.9A CN201210560369A CN103007432B CN 103007432 B CN103007432 B CN 103007432B CN 201210560369 A CN201210560369 A CN 201210560369A CN 103007432 B CN103007432 B CN 103007432B
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Abstract
The invention discloses an integrated device for modulating and detecting brain functions. A silicon rubber case is sleeved on the surface of a transcranial magnetic stimulation coil, an inner ring and an outer ring of the silicon rubber case are provided with a plurality of holes at different distances, near infrared transmitting and receiving probes can be conveniently inserted into the holes, the probes can be firmly held by the aid of elasticity of silicon rubber, the upper positions and the lower positions of the probes can be optionally adjusted, and close contact of the probes and the scalp of a detected portion is ensured. A miniature near infrared brain function detection device sets frequencies through a microprocessor, the frequencies are transmitted and received by a near infrared ray with a 690nm wavelength and a near infrared ray with a 830nm wavelength respectively, a plurality of LD (laser diode)/LED emitting light sources distributed at the center of the stimulation coil are sequentially lightened in a time-sharing multiplexing mode, signals detected by the surrounding probes are processed, changes of deoxyhemoglobin and blood flow are displayed on a liquid crystal display screen, and changes of the strength, the range and the depth of brain function activities corresponding to each detection channel through transcranial magnetic stimulation are reflected.
Description
Technical field
The present invention relates to the modulation of a kind of brain function and the integrated apparatus detected.Refer more particularly to method and integrated apparatus that a kind of non-invasive transcranial magnetic stimulation and miniature nearly Near-infrared Brain Function detection technology implement simultaneously.
Background technology
Transcranial magnetic stimulation instrument (Transcranial Magnetic Stimulation, TMS) is the new technique that the non-invasive cerebral cortex later occurred for 1985 stimulates and modulates, and is used widely in brain science research with clinical diagnosis, treatment.The magnetic field of TMS pulse ringing is without hindrance painless through skull, produces faradize cerebral cortex nerve and produce a series of physiological action and biochemical reaction at intracranial.TMS have influence in neuroscience molecule, synapse, cell, network, functional areas, system structure and decision behavior at all levels; In recent years, be day by day subject to people's attention in fields such as rehabilitation medicine, psychologic medicine, neurosciences, promoted gradually in clinical and scientific research.
The principle that TMS modulates function of nervous system acts on local nerve and network by different stimulated pattern and stimulus parameter, the synaptic connection strengths of double regulation control nerve, namely long term potentia￣tion or the long-term depression of function of nervous system is modulated, two-ways regulation nerve excitability, regulate regional cerebral blood flow and metabolism, and regulate and control function of nervous system, treatment delayed ischemic neurological deficits disease with this.
The dual regulation of TMS has stimulation frequency dependence, can improve the nerve excitability of stimulation location with high frequency repetitive stimulation, improves oxygen consumption and metabolism.The repetitive stimulation effect of low frequency is contrary, can suppress nerve excitability, reduce blood flow.But the factor affecting TMS effect of stimulation is a lot, as stimulating coil size and shape, stimulate distance and angle, stimulus intensity and pattern all can affect the effect of stimulation of TMS; The stimulation of TMS is also by neural activity state, neural activity history, neural autostability, individual variation, pathological change with pharmaceutically-actively to affect.Therefore TMS needs to consider these factors, selects the stimulus parameter of individuation, observes effect of stimulation in time, adjusts stimulus parameter in time.
TMS is usually used in stimulating the motor area of cerebral cortex, the target flesh that nervus motorius can be made to control shrinks shake, the amplitude of the Motion Evoked Potential (MEP) on conventional target flesh detects effect of stimulation, decide stimulus parameter, according to predeterminated target, artificial intervention function of nervous system carrys out the irritability of modulation movement nerve.Find again now to stimulate all the other positions of brain, (as frontal lobe back of the body outside, temporal lobe, top) can treat some psychoneural functional disorder diseases, as depression, schizophrenia etc.But stimulate these positions not have target organ effect of stimulation to be detected, the effect of conventional high frequency stimulation is subject to multifactorial impact, these uncertain factors need correct selection stimulus modelity and parameter, if effect of stimulation can not be detected in real time, can not determine that the change of the oxygen consumption of stimulation location is just difficult to determine the impact of TMS on stimulation location, be difficult to the therapeutic effect determining TMS, hamper the application of TMS, development and promote.
Because the excitement of brain and activity make metabolism increase, oxygen consumption increases; Current useful work energy magnetic resonance (fMRI) and Positron emission computed tomography imaging system (PET) detect TMS stimulates brain non-athletic district to the change of cerebral blood flow and biochemical metabolism to judge the post-stimulatory therapeutic effect of TMS, but these two kinds of equipment are all very expensive, the environment that detection time is long, head can not move, close easily produces fear of being enclosed, these unfavorable factors also have impact on results of stimulation, limit the research range of neuroscience, be difficult in clinical practice with universal.
The neural activity of brain needs oxygen consumption, and oxygen is provided by the hemoglobin in blood.The nearly near-infrared Optical Imaging of Functional Brain: An Introductory of Novel noninvasive (the Functional near infrared spectroscopy fNIRS) technology that the nineties in 20th century occurs can provide the information of intracranial oxygenated blood red eggs and deoxyhemoglobin concentration change, and the increase of neural activity and HbO2 Oxyhemoglobin, the increase of blood flow are relevant.FNIRS reflects the change of the regional oxygen uptake amount that brain function activity causes and blood flow, and its accuracy and credibility are confirmed by fMRI and PET.Near infrared ray can penetrate skull, and part near-infrared can be returned by the scattering of cerebral tissue, passes skull (penetrate darker, the distance returning skull is far away) in 3-5 centimeters.HbO2 Oxyhemoglobin and deoxyhemoglobin change to the difference of near-infrared absorption spectrum frequency, brain function activity place Oxygenated blood Lactoferrin and deoxyhemoglobin ratio, make to inject the near infrared scattered light intensity that skull arrives corticocerebral different wave length to change, can in real time this change to be detected with high-sensitive probe-photoelectric sensor, as fMRI, indirectly understood the functional activity of brain by the change detecting brain local blood oxygen and blood flow.
The operation principle of fNIRS is simple and reliable, the near infrared light that wavelength is 830nm and 690nm is launched by laser diode (LD) or light emitting diode (LED), HbO2 Oxyhemoglobin and deoxyhemoglobin can be detected respectively, available there is same frequency characteristic photoelectric receiving diode or light cell as probe, detect the near infrared scattering of different frequency, then signal is amplified, filtering, each change being positioned at light intensity on brain surface's different parts sense channel can be shown in real time, thus reflect the change of different brain position HbO2 Oxyhemoglobin and blood flow, through software processes, signal amplitude is converted to different colors, be presented on head phantom model, the change of the large brain regional blood flow of Real time dynamic display and function.
The advantage of fNIRS system be safe, easy, cost is low, can detect in real time brain local functional activity and without fixing head, repeatedly can repeat experiment.Overcome the deficiency of fMRI and PET, and be applicable to carrying out functional measurement of human brain without interfering with each other with TMS simultaneously.But these two kinds of new techniques of TMS and fNIRS only have independently equipment at present.The launching and receiving of functional near-infrared imaging equipment all passes through optical fibers, although optical fibers is not by electromagnetic interference, but the stimulating coil of TMS is difficult to mobile operation at the fibre-optic head that gathered, too much optical fibers is fixed on the headstock time-consuming bothersome, the stimulating coil of TMS cannot carry out effective location close to skull and stimulate position, cortex target area accurately in the middle of optical fibers, makes current TMS and fNIRS be difficult to work simultaneously.
Summary of the invention
Main purpose of the present invention is to provide the modulation of a kind of brain function and the integrated apparatus detected, be suitable for when implementing brain function and stimulating, detect simultaneously stimulation location deoxyhemoglobin and blood flow change so that reflect stimulation location neural activity, integrated apparatus that nerve excitability changes.Needing in Neural stem cell to understand the result-nerve excitability of stimulation location to neural two-ways regulation is increase or suppress, and corresponding is that HbO2 Oxyhemoglobin increases or reduces, and also needs scope and the degree of depth of understanding stimulation.The present invention can realize limit easily stimulates frontier inspection to look into, monitoring transcranial magnetic stimulation brain function is modulated direction, degree, coverage and the degree of depth, to select better stimulus modelity, stimulus parameter to reach desirable effect of stimulation.
Technical scheme of the present invention: a kind of brain function modulation of the present invention comprises transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument with the integrated apparatus detected, the microprocessor of described Near-infrared Brain function optical imaging instrument is connected with the external trigger of transcranial magnetic stimulation instrument by time-delay trigger, and transmitting probe and the receiving transducer of Near-infrared Brain function optical imaging instrument are nested in around the stimulating coil of transcranial magnetic stimulation instrument.
Described Near-infrared Brain function optical imaging instrument is miniature Near-infrared Brain function optical imaging instrument, comprise microprocessor, the amplifier be connected with microprocessor, wave filter, analogue selector, analog-digital converter, digital to analog converter, bidirectional constant driver, time-delay trigger, liquid crystal touch screen, bidirectional constant driver is connected with transmitting probe, and receiving transducer is connected with amplifier; Near-infrared Brain function optical imaging instrument and liquid crystal touch screen thereof are arranged on the handle of transcranial magnetic stimulation instrument.
The transmitting probe of described Near-infrared Brain function optical imaging instrument and receiving transducer are by having plasticity and elastic silica gel sheath is nested on the stimulating coil of transcranial magnetic stimulation instrument, silica gel sheath comprise bottom surface, with the jacket and inner sleeve of plane perpendicular, overcoat is enclosed within the outside of the stimulating coil of transcranial magnetic stimulation instrument, inside be embedded in the inner side of the stimulating coil of transcranial magnetic stimulation instrument, jacket and inner sleeve have probe hole is installed; The height of jacket and inner sleeve and the shape of inside and outside wall, size are mated with the stimulating coil of transcranial magnetic stimulation instrument.
The triggering signal of external trigger to transcranial magnetic stimulation instrument of described Near-infrared Brain function optical imaging instrument is: the input and output of probe locked in the out-of-work 1ms of Near-infrared Brain function optical imaging instrument, the stimulating coil that time delay 0.5ms triggers transcranial magnetic stimulation instrument produces 0.3ms pulsed magnetic field, after pulsed magnetic field exports and stops, after 0.2ms, Near-infrared Brain function optical imaging instrument unlocks.
The constant-current circuit that bidirectional constant drive circuit in described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and is attached thereto, the transmitting probe of two-way antiparallel two LEDs of outfan Direct driver of bidirectional bridge type drive circuit or laser diode LD composition, the wavelength of a luminous tube is 830nm, the wavelength of another luminous tube is 690nm, and the near infrared light of being taken turns two luminous tubes of current control different wave length by microprocessor timesharing is launched; The input of constant-current circuit and being connected to set output terminal of microprocessor, regulated the size of constant current by microprocessor.
Described transmitting probe and receiving transducer are elongated cylindrical, conveniently can insert the installation hole on silica gel sheath, be clamped by elastic silica gel hole, and scalable, installing the degree of depth in hole, reaches the close contact with scalp.
The described transmitting probe of Near-infrared Brain function optical imaging instrument and the installation position of receiving transducer according to detect position need select installation site, keep distance to be between the two 3 ~ 5cm.
Preferably, the probe that the transmitting probe of described Near-infrared Brain function optical imaging instrument and receiving transducer are placed on the jacket and inner sleeve of silica gel sheath is respectively installed in hole, and the distance between transmitting probe and receiving transducer is 3-5cm.More preferably receiving transducer is placed on the inner sleeve of silica gel sheath, in stimulating coil centre.
The transmitting probe of described Near-infrared Brain function optical imaging instrument establishes 1 ~ 10, receiving transducer 1 ~ 10; Probe diameter is all 2.5mm.
Advantage of the present invention: set the near infrared emission of two kinds of wavelength and the operating frequency of reception by microprocessor in miniature Near-infrared Brain function optical imaging instrument of the present invention, continuous wave time-sharing multiplex pattern is adopted to light several transmitting probes be distributed in inside stimulating coil successively in turn, with 690nm, the Neural stem cell position that the near infrared light of 830nm wavelength is to be measured, then the optical signal after tissue attenuation is received by several detectors outside stimulating coil, amplify through opto-electronic conversion and signal, Filtering Processing also carries out analog/digital conversion, while utilizing software controlled circuitry timesharing to take turns to operate, real-time operation is carried out to the multi-channel data gathered, and the change of HbO2 Oxyhemoglobin and blood flow is gone out in small-sized liquid crystal screen display, reflect the power of brain zone function activity corresponding to each access sites, the change that movable scope and the degree of depth occur.
The present invention simply saves time when clinical manipulation, first utilize support relative with the head of irriate person for stimulating coil 1a fixing, then just allow two kinds of equipment be independent of each other by the hole on magnetic stimulating coil silica gel sheath and scalp close contact near infrared transmitting probe and receiving transducer, work simultaneously.
Expense of the present invention is low, only need customize the silica gel sheath of the TMS stimulating coil of low cost, both may be used for existing TMS equipment, and can be used for again redesign and the making of novel TMS equipment.The silica gel sheath of low cost was both convenient to cleaning and sterilizing, the consumptive material that can be used alone as patient again.
The invention process is simple, easy to operate, is convenient to according to real-time fNIRS testing result adjustment stimulus parameter and stimulus modelity in stimulation, to reach the expection object of intervening function of nervous system.Invention increases the stimulation curative effect of TMS, expand the range of application of fNIRS, for the scientific research of neuroscience, detection, treatment provide a kind of new method and utility.
In sum, the present invention combines the new technique in two kinds of neurosciences, detects the effect of stimulation that TMS stimulates any position of brain in real time with fNIRS.Solve the difficult problem that TMS stimulates non-athletic district not have target organ to detect.Eliminate the high medical expense that fMRI, PET detect TMS effect of stimulation.
Accompanying drawing explanation
Fig. 1 is circuit theory logic diagram of the present invention.
Fig. 2 is the bidirectional constant driving principle block diagram of miniature Near-infrared Brain function optical imaging instrument.
Fig. 3 be the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer be nested in transcranial magnetic stimulation instrument stimulating coil inside and outside schematic diagram.
Fig. 4 is the A-A sectional view of Fig. 3.
Fig. 5 is the schematic diagram of silica gel sheath.
Fig. 6 is that the present invention is to the brain function modulation of people and the schematic diagram used when detecting.
Fig. 7 is transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument time-sharing work oscillogram.
Fig. 8 is the graph of a relation of distance between transmitting probe and receiving transducer and investigation depth.
Fig. 9 is the schematic diagram of the present invention for figure-eight coil.
Detailed description of the invention
Embodiments of the invention are described in further detail below in conjunction with accompanying drawing.
Fig. 1 is circuit theory logic diagram of the present invention:
The invention provides the modulation of a kind of brain function and the integrated apparatus detected, comprise transcranial magnetic stimulation instrument 1 and Near-infrared Brain function optical imaging instrument 2, the microprocessor of described Near-infrared Brain function optical imaging instrument 2 is connected with the external trigger of transcranial magnetic stimulation instrument by time-delay trigger, and the transmitting probe 2a of Near-infrared Brain function optical imaging instrument 2 and receiving transducer 2b is nested in around the stimulating coil 1a of transcranial magnetic stimulation instrument.
Near-infrared Brain function optical imaging instrument of the present invention is miniature Near-infrared Brain function optical imaging instrument, comprise microprocessor, the amplifier be connected with microprocessor, wave filter, analogue selector, analog-digital converter, digital to analog converter, bidirectional constant driver, time-delay trigger, liquid crystal touch screen, bidirectional constant driver is connected with transmitting probe 2a, and receiving transducer 2b is connected with amplifier.
Fig. 2 is the bidirectional constant driving principle block diagram of miniature Near-infrared Brain function optical imaging instrument:
The constant-current circuit that bidirectional constant drive circuit in described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and is attached thereto, the transmitting probe of two-way antiparallel two light emitting diodes composition of outfan Direct driver of bidirectional bridge type drive circuit, the wavelength of a luminous tube is 830nm, the wavelength 690nm of a luminous tube, the near infrared light of being taken turns two luminous tubes of current control different wave length by microprocessor timesharing is launched; The input of constant-current circuit and being connected to set output terminal of microprocessor.
The bridge circuit of bidirectional constant driver is made up of audion Q1 ~ Q4, two-way antiparallel two light emitting diodes (LED) of outfan Direct driver of bridge circuit or laser diode (LD), when bridge circuit audion Q1 ~ Q4 brachium pontis conducting, flow through the luminous tube of D830nm, during Q2, Q3 conducting of brachium pontis audion, the luminous tube conducting of D690nm, interlaced pulse control Q6 and Q7 that the control of the near-infrared light source of conducting is in turn sent by microprocessor completes.Constant-current circuit is made up of audion Q5, resistance R9, R10 and amplifier A, received the anode of amplifier in through the given output intensity that D/A changes by microprocessor, negative terminal is received on current detection feedback resistance R9, when electric current is less than set-point, audion Q5 conducting, when electric current is greater than set-point, voltage drop on R9 increases, the negative terminal voltage of amplifier A increases, exporting reduction makes Q5 turn off, output current, with the conducting state of negative feedback type control Q5, reaches electric current according to set-point constant output.
Described pick-up probe is the near-infrared light sensitive diode of available respective wavelength, audion, photoconductive resistance or light-sensitive cell also, and optical fibers also can be adopted to conduct the near infrared signal detected.
Fig. 7 is transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument time-sharing work oscillogram:
The triggering signal of external trigger to transcranial magnetic stimulation instrument of Near-infrared Brain function optical imaging instrument is: the input and output of probe locked in the out-of-work 1ms of Near-infrared Brain function optical imaging instrument, the stimulating coil that time delay 0.5ms triggers transcranial magnetic stimulation instrument produces 0.3ms pulsed magnetic field, after pulsed magnetic field exports and stops, after 0.2ms, Near-infrared Brain function optical imaging instrument unlocks.Avoid Neural stem cell and near-infrared to work simultaneously, hide the strong pulsed magnetic field of transcranial magnetic stimulation device output to the interference of near infrared device.The operating frequency of transcranial magnetic stimulation device is generally 1 ~ 100HZ, and namely each treatment cycle is 10 ~ 1000ms.
Fig. 5 is the schematic diagram of silica gel sheath:
The transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are by having plasticity and elastic silica gel sheath is nested on the stimulating coil of transcranial magnetic stimulation instrument, silica gel sheath comprise bottom surface 2g, with the overcoat 2c of plane perpendicular and inner sleeve 2d, overcoat 2c is enclosed within the outside of the stimulating coil of transcranial magnetic stimulation instrument, inner sleeve 2d is embedded in the inner side of the stimulating coil of transcranial magnetic stimulation instrument, overcoat 2c and inner sleeve 2d has probe install hole; The height of overcoat 2c and inner sleeve 2d and the shape of inside and outside wall, size are mated with the stimulating coil of transcranial magnetic stimulation instrument.
Silica gel sheath is the physical dimension according to magnetic stimulation coil, and make the silica gel outer of a stimulating coil, outer edge is turned back so that stimulating coil firmly embeds within silica gel outer.Several are provided with apart from different installation holes inside and outside silica gel outer, be convenient near infrared emission and receiving transducer inserts hole, utilize the elasticity of silica gel, enable less hole secure grip cylindrical elongate probe also arbitrarily can regulate the orientation up and down of probe, ensure probe and the scalp close contact detecting position.
Fig. 3, Fig. 4 be the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer be nested in transcranial magnetic stimulation instrument stimulating coil inside and outside schematic diagram: transmitting probe and receiving transducer are elongated cylindrical, conveniently can insert the installation hole on silica gel sheath, clamped by elastic silica gel hole, the scalable depth reaches the close contact with scalp.
The transmitting probe of Near-infrared Brain function optical imaging instrument establishes 1 ~ 10, preferably 1; Receiving transducer 1 ~ 10, preferably 2; Installation position, according to the installation hole needing to select silica gel sheath detecting position, keeps distance to be between the two 3 ~ 5cm.The probe of overcoat 2c and inner sleeve 2d that preferred emission probe and receiving transducer are placed on silica gel sheath is respectively installed in hole.
The probe of overcoat 2c and inner sleeve 2d that the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are placed on silica gel sheath is respectively installed in hole, and the transmitting probe of Near-infrared Brain function optical imaging instrument establishes 1 ~ 10, receiving transducer 1 ~ 10.The probe of overcoat 2c and inner sleeve 2d that the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are placed on silica gel sheath is respectively installed in hole, and the distance between transmitting probe and receiving transducer is 3-5cm.Miniature Near-infrared Brain function optical imaging instrument 2 and liquid crystal touch screen 2e thereof are arranged on the handle 1b of transcranial magnetic stimulation instrument.
Miniature Near-infrared Brain function optical imaging instrument of the present invention comprises the color touch liquid crystal display screen of 2.5 cun as man-machine dialogue interface, by the testing result of curve or different colors display different parts, select near infrared emission with touch screen and detect the quantity of leading and combination, the drive current selecting to regulate light source probe, the parameter such as amplification, sweep duration, filtering that selection and adjustment are respectively led.
Fig. 6 is that the present invention modulates and the schematic diagram used when detecting the brain function of people:
The launching and receiving probe of miniature Near-infrared Brain function optical imaging instrument connects near infrared emission probe 2a and receiving transducer 2b with twisted-pair feeder by sleeve pipe 2f.Transmitting probe 2a and receiving transducer 2b inserts in installation holes different on silica gel sheath respectively, forms the combination of some time-sharing multiplexs, to detect different parts, different range, the HbO2 Oxyhemoglobin of different depth and the change of blood flow.
Particularly, miniature Near-infrared Brain function optical imaging instrument is fixed on the handle 1b of the stimulating coil 1a of transcranial magnetic stimulation instrument.Silica gel sheath static probe, as the integrated carrier that two kinds of equipment use simultaneously.Silica gel sheath is different size and shapes according to different coil design, edge opisthotonos can hold stimulating coil 1a, keep combining closely with stimulating coil 1a, utilize elasticity and the plasticity of silica gel material, can insert and closely grip transmitting probe 2a and receiving transducer 2b, object is in order to transmitting probe 2a and receiving transducer 2b is fixed on inside and outside stimulating coil 1a, and energy close contact scalp, probe is moved along with the movement of stimulating coil 1a, arbitrarily detects function of nervous system's change of any stimulation location.
Fig. 8 is the graph of a relation of distance between transmitting probe and receiving transducer and investigation depth:
Distance between transmitting probe with receiving transducer is relevant with the degree of depth at detection position, as distance L1=3cm between the two, investigation depth H1=3cm, if the distance of detecting head and light source is increased to L2=5cm, then investigation depth H2=5cm, therefore regulate the distance between receiving transducer and transmitting probe can increase detection range and the degree of depth, the situation of intracranial blood oxygen and blood flow can be detected with multiple transmitting probe simultaneously on a large scale, and then more scope and the intensity reflecting brain neurological motion.
Fig. 9 is the schematic diagram of the present invention for figure-eight coil: described stimulating coil silica gel outer can make different size and shapes, to adapt to various stimulating coil, as the most frequently used circle or figure-eight coil.
The foregoing is only the preferred embodiments of the present invention; not thereby limit the scope of the invention; every utilize content of the present invention to do equivalent structure or flow process conversion, or be directly or indirectly used in other relevant technical field, all in protection scope of the present invention.
Claims (8)
1. a brain function modulation and the integrated apparatus detected, comprise transcranial magnetic stimulation instrument and Near-infrared Brain function optical imaging instrument, it is characterized in that: the microprocessor of described Near-infrared Brain function optical imaging instrument is connected with the external trigger of transcranial magnetic stimulation instrument by time-delay trigger, the transmitting probe of described Near-infrared Brain function optical imaging instrument and receiving transducer are by having plasticity and elastic silica gel sheath is nested on the stimulating coil of transcranial magnetic stimulation instrument, silica gel sheath comprises bottom surface, with the jacket and inner sleeve of plane perpendicular, overcoat is enclosed within the outside of the stimulating coil of transcranial magnetic stimulation instrument, inside be embedded in the inner side of the stimulating coil of transcranial magnetic stimulation instrument, jacket and inner sleeve there is probe hole is installed, the height of jacket and inner sleeve and the shape of inside and outside wall, size are mated with the stimulating coil of transcranial magnetic stimulation instrument, the triggering signal of external trigger to transcranial magnetic stimulation instrument of Near-infrared Brain function optical imaging instrument is: the input and output of probe locked in the out-of-work 1ms of Near-infrared Brain function optical imaging instrument, the stimulating coil that time delay 0.5ms triggers transcranial magnetic stimulation instrument produces 0.3ms pulsed magnetic field, after pulsed magnetic field exports and stops, after 0.2ms, Near-infrared Brain function optical imaging instrument unlocks.
2. brain function modulation according to claim 1 and the integrated apparatus detected, it is characterized in that: described Near-infrared Brain function optical imaging instrument is miniature Near-infrared Brain function optical imaging instrument, comprise microprocessor, the amplifier be connected with microprocessor, wave filter, analogue selector, analog-digital converter, digital to analog converter, bidirectional constant driver, time-delay trigger, liquid crystal touch screen, bidirectional constant driver is connected with transmitting probe, and receiving transducer is connected with amplifier; Near-infrared Brain function optical imaging instrument and liquid crystal touch screen thereof are arranged on the handle of transcranial magnetic stimulation instrument.
3. brain function modulation according to claim 2 and the integrated apparatus detected, it is characterized in that: the constant-current circuit that the bidirectional constant drive circuit in described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and is attached thereto, the transmitting probe of two-way antiparallel two LEDs of outfan Direct driver of bidirectional bridge type drive circuit or laser diode LD composition, the wavelength of a luminous tube is 830nm, the wavelength of another luminous tube is 690nm, the near infrared light of being taken turns two luminous tubes of current control different wave length by microprocessor timesharing is launched, the input of constant-current circuit and being connected to set output terminal of microprocessor, regulated the size of constant current by microprocessor.
4. brain function modulation according to claim 1 and 2 and the integrated apparatus detected, it is characterized in that: transmitting probe and receiving transducer are elongated cylindrical, conveniently can insert the installation hole on silica gel sheath, clamped by elastic silica gel hole, scalable, installing the degree of depth in hole, reaches the close contact with scalp.
5. brain function modulation according to claim 1 and 2 and the integrated apparatus detected, it is characterized in that: the transmitting probe of Near-infrared Brain function optical imaging instrument and the installation position of receiving transducer according to detect position need select installation site, keep distance to be between the two 3 ~ 5cm.
6. brain function modulation according to claim 2 and the integrated apparatus detected, it is characterized in that: the constant-current circuit that the bidirectional constant drive circuit in described Near-infrared Brain function optical imaging instrument comprises bidirectional bridge type drive circuit and is attached thereto, the transmitting probe of two-way antiparallel two photosensitive tubes composition of outfan Direct driver of bidirectional bridge type drive circuit, the wavelength of a light emitting diode is 830nm, the wavelength of another light emitting diode is 690nm, and the near infrared light of being taken turns two photosensitive tubes of current control different wave length by microprocessor timesharing is launched; The input of constant-current circuit and being connected to set output terminal of microprocessor.
7. brain function modulation according to claim 1 and 2 and the integrated apparatus detected, it is characterized in that: the probe of overcoat (2c) and inner sleeve (2d) that the transmitting probe of Near-infrared Brain function optical imaging instrument and receiving transducer are placed on silica gel sheath is respectively installed in hole, and the distance between transmitting probe and receiving transducer is 3-5cm.
8. brain function modulation according to claim 1 and 2 and the integrated apparatus detected, is characterized in that: the transmitting probe of Near-infrared Brain function optical imaging instrument establishes 1 ~ 10, receiving transducer 1 ~ 10; Probe diameter is all 2.5mm.
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