CN103007422A - Multidirectional valve hydrocephalus shunt valve with antibacterial and anticoagulant functions, and preparation and application method thereof - Google Patents
Multidirectional valve hydrocephalus shunt valve with antibacterial and anticoagulant functions, and preparation and application method thereof Download PDFInfo
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- CN103007422A CN103007422A CN2012105813146A CN201210581314A CN103007422A CN 103007422 A CN103007422 A CN 103007422A CN 2012105813146 A CN2012105813146 A CN 2012105813146A CN 201210581314 A CN201210581314 A CN 201210581314A CN 103007422 A CN103007422 A CN 103007422A
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- isocon
- valve
- hydrocrania
- anticoagulant
- multidirectional
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
- A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
- A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
Abstract
The invention discloses a multidirectional valve hydrocephalus shunt valve with antibacterial and anticoagulant functions, and preparation and an application method thereof, and belongs to the field of medical equipment. Two ends of a drainage tube are sealed through a silicone hose; a plurality of long seams are axially cut on the side wall at one end of the drainage tube, so as to form a valve type channel; and a hole is punched in the side wall at the other end of the drainage tube, which is served as a channel for allowing intracranial liquid to flow into the hydrocephalus shunt. At least one type of antibacterial drug permeates in the shunt valve body, so as to prevent wound from being infected; and meanwhile, anticoagulant drugs are connected with the surface of the tube wall in a surface grafting manner, so as to prevent blood corpuscle and protein in hydrocephalus from being adhered to the inner tube wall and causing lumen blockage. The shunt valve is used for the drainage of hydrocephalus from brain to other body cavities, the antibacterial and anticoagulant design can effectively prevent infection and vessel clogging in hydrocephalus shunt, the multidirectional valve design at the remote end can prevent liquid from flowing back, and the hydrocephalus shunt valve is multifunctional.
Description
Technical field
The present invention relates to the hydrocrania dividing technology, specifically is about a kind of multidirectional valve hydrocrania isocon with antibiosis anticoagulative function and preparation method thereof, using method.
Background technology
Hydrocephalus is the common disease of neurosurgery, and relatively effective method remains by operating means treatment at present, and bypass is wherein a kind of operation commonly used.What present hydrocrania bypass was commonly used is ventriculo-peritoneal shunt, and the isocon of employing is simple silica gel tube.The limitation of ventriculo-peritoneal shunt is at present: 1, the hemocyte in the hydrocephalus and protein adhere to and freeze solidly on the obstruction that tube wall causes isocon easily, bring very big inconvenience to operation; 2, hydrocephalus is drained into the abdominal cavity from brain, need the subcutaneous isocon path of implantation oversize, larger being easy to of wound surface felt.3, very easily infect in the drain process, particularly intracranial infection.Intracranial infection is a very stubborn problem always, causes easily a lot of intracranial diseases, so postoperative patient generally need to be taken a large amount of broad ectrum antibiotic, a large amount of antibiotic not only to human body have harm and also efficient very low.4, the isocon scope of application is little, and a kind of isocon only can be used for a kind of hydrocrania bypass of path, so that isocon can not Produce on a large scale.Defects has brought very large risk to the hydrocephalus bypass, has brought a lot of inconvenience also for doctor and nursing staff.
Summary of the invention
To all inconvenience that operation brings, the purpose of this invention is to provide a kind of multidirectional valve hydrocrania isocon with antibiosis anticoagulative function and preparation method thereof, using method for present isocon, mainly solve the antibiosis anticoagulative problem in the hydrocrania bypass.
The technical scheme that the present invention takes is:
A kind of multidirectional valve hydrocrania isocon with antibiosis anticoagulative function, as body take a silica gel hose, two endcappeds with body, offer several apertures at the sidewall near an end, offer the valve opening that several are offered vertically at the sidewall near another end;
In described body infiltration at least a antibacterials are arranged, and be grafted with anticoagulant at the inside and outside wall of pipe.
Described multidirectional valve hydrocrania isocon with antibiosis anticoagulative function, described several apertures are evenly to distribute on the circumferential same cross section of pipe, and between adjacent two cross sections mutual dislocation.
Described several valve openings are for axially cutting 2～4 slits establishing along pipe, and about length 1cm, these slits upwards evenly distributed in pipe week, and every adjacent two slits are at the tubular axis 1 ± 0.2cm that upwards staggers.
Described several valve openings are at distance adjacent end 0.5～2cm place.
The described antibacterials of infiltration are the combination of a kind of in rifampicin and the nitrofural or two kinds.
The anticoagulant of grafting is heparin sodium.
The present invention's preparation has the method for the multidirectional valve hydrocrania isocon of antibiosis anticoagulative function, comprises the steps:
1) isocon preparation
With silica gel hose two ends end socket rounding, at distance one end 0.5～2cm place, process 2～4 slits, described slit upwards evenly distributes at caliber, and every adjacent two slits upwards stagger about 1cm at tubular axis; Near another end, offer a plurality of apertures, described aperture along pipe circumferentially evenly distribute, mutual dislocation vertically;
2) antimicrobial treatment
Take one of following three kinds of methods:
1. selecting rifampicin is antibacterials, and compound concentration is rifampicin-chloroformic solution of 1～4g/L, and isocon is soaked 5～60min, and the rear first drying of immersion is gone molten, dry again after the washing;
2. selecting nitrofural is antibacterials, and compound concentration is nitrofural-dimethyl sulfoxide solution of 0.1～5g/L, and isocon is soaked 5～60min, and the rear first drying of immersion is gone molten, dry again after the washing;
3. select rifampicin and nitrofural jointly to be antibacterials, first isocon in being rifampicin-chloroformic solution of 1～4g/L, concentration is soaked 5～60min, drying is gone molten, after washing again drying, in being nitrofural-dimethyl sulfoxide solution of 0.1～5g/L, concentration soaks 5～60min again, elder generation's drying is gone molten, and is dry again after the washing;
3) anticoagulant is processed
The selection heparin sodium is anticoagulant, and compound concentration is the heparin sodium aqua of 10～100g/L, soaks therein 2～48h with managing the isocon of inside and outside wall through finishing after the antimicrobial treatment, and soaking temperature is 20～40 ℃, and taking-up is dry after soaking.
Described preparation method with multidirectional valve hydrocrania isocon of antibiosis anticoagulative function, described finishing is the plasma sputtering finishing, concrete grammar is: isocon is placed the plasma immersion ion injection device, behind the evacuation, pass into one of hydrogen, nitrogen, steam or ammonia, gas pressure is 0.05～50P; Radio-frequency discharge power is 200～1200W; The pulsed high voltage generator amplitude that loads is 1kV～100kV, and frequency is 50～40000Hz or alternating current power supply 10～20MHz, dutycycle 3%～80%; 20～200 ℃ of heating-up temperatures, the processing time is 0.1～5h.
The present invention also provides a kind of described method with multidirectional valve hydrocrania isocon of antibiosis anticoagulative function of using, and carries out according to the following steps:
1) in the boring of brain corresponding site, the position that intracranial has hydrocrania is inserted in the foraminate end puncture of isocon band;
2) in the lacuna place boring of needs introducing hydrocrania, with the end insertion lacuna of isocon with the valve opening, get final product drain.
Adopt above technical scheme, the multidirectional valve hydrocrania isocon with antibiosis anticoagulative function that the present invention relates to has following advantage:
1, this isocon is used for the shunting of hydrocrania, uniform aperture is set as the passage of hydrocrania to tube chamber at the near-end of pipe; Far-end arranges the valve opening, has further ensured the unipolarity of drain.Especially the valve opening on the isocon, when hydrocrania too much caused intracranial hypertension, valve-open was carried out normal drain; Valve was closed when Reducing Intracranial Pressure was extremely normal, prevented liquid return.Isocon configuration tearable catheter sheath can be used for the drain of cerebrospinal fluid from the intracranial to the venous sinus, and it is little, simple to operate to compare traditional shunting mode wound.
2, this isocon surface uses rifampicin and/or nitrofural as antibacterials successively, carrying out antibiosis anticoagulative with heparin sodium as anticoagulant processes, be convenient to long-term implantation, effectively protect from infection and stop up, solved two large complication of present hydrocrania shunt operation.
Description of drawings
Fig. 1 is the multidirectional valve hydrocrania isocon structural representation of antibiosis anticoagulative of the present invention.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is described in detail.
Introduce first the architectural feature of isocon in conjunction with Fig. 1.Isocon is silica gel hose, is divided into near-end 1 and far-end 2 by drain body flow direction, is interlude 3 between near-end 1 and the far-end 2.
Near-end 1 has the place of hydrocrania for inserting intracranial or lumbar vertebra, stops up the mouth of pipe for preventing insertion process, and the terminal end socket of near-end 1, sidewall offer a plurality of apertures 4 flow into isocon as liquid passage.These hole shapes, size, arrangement mode do not have inevitable requirement, but preferably size is even, and evenly distribute mutual dislocation between adjacent two sections on the circumferential same cross section of pipe.The aperture of so arranging is more suitable for drain, and the mechanical performance of perforation is also more even like this.
Far-end 2 is used for inserting the lacuna that hydrocrania flows into, its end is end socket also, and sidewall adopts valve opening 5, namely be provided with 2～4 slits about 1cm cutting vertically on the tube wall, these slits upwards evenly distributed in pipe week, at the tubular axis certain distance that upwards mutually staggers, be used for control drain pressure.Valve is opened when intracranial pressure is larger, carries out normal drain; When intracranial pressure reached normal level, valve was closed, and prevented liquid return.
Near-end 1 aperture 4 is mainly used in hydrocrania to the passage of tube chamber; The valve opening 5 of far-end 2 is in order further to ensure the unipolarity of drain, when intracranial pressure is higher, the valve internal pressure is greater than the valve external pressure, valve is opened, hydrocrania flows into venous sinus, and when Reducing Intracranial Pressure arrived normal level, the valve external and internal pressure equated, valve is in closed condition, and blood can not flow backwards back in the isocon.
In order to make isocon have the antibiosis anticoagulative effect, the present invention also permeates between isocon silica gel organizational structure and is distributed with at least a antibacterials, and at tube surface grafting anticoagulant.Basic ideas are: with the isocon solution soaking that is dissolved with antibacterials for preparing on the structure, with the plasma sputtering modification technique catheter surface is carried out modification again, at last with the solution soaking that is dissolved with anticoagulant.
Wherein the antimicrobial treatment concrete grammar is as follows:
The antibacterials of selecting are rifampicin, and soak is that concentration is rifampicin-chloroformic solution of 1～4g/L, and soak time is 5～60min; The rear first drying of immersion is gone molten, and is dry again after the washing.
Perhaps, the antibacterials of selection are nitrofural, and soak is that concentration is nitrofural-dimethyl sulfoxide solution of 0.1～5g/L, and soak time is 5～60min; The rear first drying of immersion is gone molten, and is dry again after the washing.
Again or, the antibacterials of selecting are two kinds of rifampicin and nitrofurals, first isocon in being rifampicin-chloroformic solution of 1～4g/L, concentration is soaked 5～60min, that drying is gone is molten, wash again drying after, soak 5～60min again in concentration is nitrofural-dimethyl sulfoxide solution of 0.1～5g/L, that drying is gone is molten, dry again after the washing.
Anticoagulant is processed and must be carried out after antimicrobial treatment, and it is as follows that concrete grammar is processed in anticoagulant:
The anticoagulant of selecting is heparin sodium, is mixed with the heparin sodium aqua that concentration is 10～100g/L, and soaking temperature is 20～40 ℃, will through behind the immersion of the isocon after the antimicrobial treatment 2～48h, take out dry.
Preferably process drainage tube with the plasma sputtering modification technique first before anticoagulant is processed, be conducive to like this increase anticoagulant in the bond strength of tube wall, make the anticoagulant effect more lasting.
Plasma sputtering of the present invention is modified concrete grammar: isocon is placed the plasma immersion ion injection device, behind the evacuation, pass into one of hydrogen, nitrogen, steam or ammonia, gas pressure is 0.05～50P; Radio-frequency discharge power is 200～1200W; The pulsed high voltage generator amplitude that loads is 1kV～100kV, and frequency is 50～40000Hz or alternating current power supply 10～20MHz, dutycycle 3%～80%; 20～200 ℃ of heating-up temperatures, the processing time is 0.1～5h.
Comprehensive, the multidirectional valve hydrocrania isocon with antibiosis anticoagulative function provided by the present invention not only has novel multidirectional valve structure, after drug treating, also contains the medicine of two kinds of functions of antibiosis anticoagulative.Can dispose separately the parts such as puncture needle, seal wire for ease of operation during use.
The medicine of the first function of selecting among the present invention is antibacterials, can select one or both uses of arranging in pairs or groups together in rifampicin, the nitrofural; The medicine of the second function is anticoagulant, can select heparin sodium.
Preparation technology of the present invention is as follows:
1, isocon preparation
With silica gel hose two ends end socket rounding, at one end apart from closed round end 0.5～2cm place, carry out the molding of multidirectional valve opening with numerical control device, the slit of opening valve for axially offering along pipe, quantity is 2～4, about length 1cm, along upwards evenly distributing in week of pipe, axially stagger about 1 ± 0.2cm pipe in every adjacent two slits.Other end sidewall at pipe is offered aperture, and preferably size evenly and at pipe circumferentially evenly distributes.
2, antimicrobial treatment
Claim a certain amount of rifampicin, be made into the solution that concentration is 1～4g/L with chloroform, as antibiotic medicinal liquid one; Perhaps claim a certain amount of nitrofural, be mixed with the solution that concentration is 0.1～5g/L with dimethyl sulfoxine, as antibiotic medicinal liquid two.
With the isocon for preparing be put in soak 5～60min in the antibiotic medicinal liquid one after, taking out pipe dries under 30～60 ℃ of temperature, again with purified water flushing pipe inside and outside wall, the pipe after the flushing put into oven for drying again after, obtain containing the isocon of rifampicin antibacterials.
Perhaps, change antibiotic medicinal liquid one into antibiotic medicinal liquid two, obtain containing the isocon of nitrofural antibacterials after processing as stated above.
If the isocon after antibiotic medicinal liquid one is handled immersed in the antibiotic medicinal liquid two again processes again one time by same procedure, then can be contained simultaneously the isocon of rifampicin and two kinds of antibacterials of nitrofural.
3, tube wall surface is modified
This step purpose is to increase the tube wall surface activity makes pipe be combined better with anticoagulant.The general plasma sputtering modification technique that adopts, concrete grammar is: isocon is placed the plasma immersion ion injection device, behind the evacuation, pass into one of hydrogen, nitrogen, steam or ammonia, gas pressure is 0.05～50P; Radio-frequency discharge power is 200～1200W; The pulsed high voltage generator amplitude that loads is 1kV～100kV, and frequency is 50～40000Hz or alternating current power supply 10～20MHz, dutycycle 3%～80%; 20～200 ℃ of heating-up temperatures, the processing time is 0.1～5h.
4, anticoagulant is processed
To put into the heparin solution that concentration is 10～100g/L through the good pipe of antimicrobial treatment, the control temperature is 20～40 ℃, soak 2～48h, then put into 30～40 ℃ of baking ovens until fully dry, anticoagulant grafts on inside and outside wall surface (also inside and outside wall all has anticoagulant); Finally obtain having the isocon of antibiosis anticoagulative effect.
Antibiosis anticoagulative isocon with the method preparation has two kinds of special microstructures.Isocon after antimicrobial treatment, the antibacterials uniformly penetrating is in the silica gel organizational structure; After the tube wall surface plasma treatment, tube wall surface silica gel activity improves, and hydrophilic increases, and between silica gel tube tube wall and the anticoagulant good combination is arranged when anticoagulant is processed.Two kinds of microstructures make the medicine energy of two kinds of functions firm, are evenly distributed in tube wall, bring into play enduringly the effect of antibiosis anticoagulative.
The blockage resisting effect of isocon of the present invention mainly is to embody by the anticoagulant effect, if the anticoagulant of pipe has been got well, isocon inner chamber and punching and joint-cutting place protein and the hemocyte in just can adsorption and drainage liquid just is not easy to cause plugging.
Rifampicin-chloroformic solution, concentration 4g/L.
Nitrofural-dimethyl sulfoxide solution, concentration 1g/L.
Heparin sodium-aqueous solution, concentration 50g/L.
1, the hydrocephalus isocon is placed concentration 4g/L rifampicin-chloroformic solution soak 5min, in 60 ℃ of baking ovens, dry after taking out.
2, the pipe that step 1 is obtained uses the same method with concentration 1g/L nitrofural-dimethyl sulfoxide solution and processes one time.
3, the pipe that step 2 is obtained is placed in the plasma immersion ion injection device, behind the evacuation, passes into hydrogen, and gas pressure is 5P; Radio-frequency discharge power is 200W; The pulsed high voltage generator amplitude that loads is 1kV, dutycycle 3%; 20 ℃ of heating-up temperatures, the processing time is 0.1h.
4, the isocon that step 3 is obtained is put into concentration 50g/L heparin sodium-aqueous solution of 20 ℃ and is soaked 2h, then with the purified water flushing, in 30 ℃ of oven dry.
5, conventional paper plastic bag packing is finished product behind the ethylene oxide sterilizing.
The preparation of reference example 1 step.Wherein omit step 2, i.e. antibacterials working concentration 4g/L rifampicin-chloroformic solution only.
Embodiment 3
The preparation of reference example 1 step.Antibacterials working concentration 1g/L nitrofural-dimethyl sulfoxide solution only wherein.
The preparation of reference example 1 step.Wherein working concentration is 1g/L rifampicin-chloroformic solution, and soak time is 5min; Working concentration is 0.1g/L nitrofural-dimethyl sulfoxide solution, soak time 60min; Step 4 passes into steam, gas pressure 50 handkerchiefs, radio-frequency discharge power 1200W, the pulsed high voltage generator amplitude 50KV of loading, AC plasma source 13.56 megahertzes, dutycycle 80%, 40 ℃ of heating-up temperatures, 30 minutes processing times; The heparin sodium concentration of aqueous solution is 100g/L, 40 ℃ of soaking temperatures, 24 hours time.
Embodiment 5:
The preparation of reference example 1 step.Wherein working concentration is 3g/L rifampicin-chloroformic solution, and soak time is 60min; Working concentration is 5g/L nitrofural-dimethyl sulfoxide solution, soak time 5 minutes; Step 4 passes into ammonia, gas pressure 20 handkerchiefs, radio-frequency discharge power 600W, the pulsed high voltage generator amplitude 20KV of loading, 50 hertz of frequencies, dutycycle 20%, 20 ℃ of heating-up temperatures, 5 hours processing times; The heparin sodium concentration of aqueous solution is 10g/L, 20 ℃ of soaking temperatures, 48 hours time.
The experiment effect checking
1, the experiment of conduit drug release in the simulation human body environment
Detect sampling: after isocon of the present invention being put into the buffer of 5ml pH7.2, under 37 ℃, carry out rifampicin and nitrofural drug release test.At each time point taking-up conduit of 1 week, 2 weeks, 4 weeks and 12 weeks, with putting into the lixiviate of 37 ° of manual simulation blood environments behind the distilled water flushing.Before the immersion, after soaking and after discharging that sample is fully dry, weigh with 1,000,000/precision balance, lose method calculating release rate every day with weight.
The result: the average burst size of the medicine of every day, rifampicin are to discharge 0.05%～0.1wt% average every day, and the per day burst size of nitrofural is 0.15-0.2wt%.Show that two kinds of medicines that are stored in the silica gel can slowly discharge for a long time, be conducive to the hydrocrania isocon and stay for a long time pipe, protect from infection.
2, the experiment of antibiotic, the anticoagulant effect of conduit
A) antibacterial experiment
Experimental technique: the various embodiments described above are processed the isocon obtain and the isocon of unprocessed mistake contacts respectively staphylococcus, escherichia coli and mixed vaccine (not exposing 1 hour under the disinfecting air environment equally), make sample for 0.5 centimetre in the middle of getting, put into 37 ℃ of bacteria culture medias and cultivate 24h, the clump count around the counting sample.
Experimental result is referring to table 1.
Table 1: the antibacterial effect of isocon before and after processing
* positive control is the ordinary silicon sebific duct of processing without antibiosis anticoagulative.
Table 1 result shows to have the effect of obvious bacteria growing inhibiting than the ordinary silicon sebific duct through the pipe of antimicrobial treatment of the present invention; Embodiment 5 uses multiple antibacterials, and antibacterial effect is more outstanding, and antimicrobial spectrum broadening.
B) anticoagulant experiment
Each embodiment conduit and untreated isocon (positive control) are immersed respectively in the mixed solution (ratio is 1:100) of fresh Sanguis sus domestica and cerebrospinal fluid, leave standstill and took out afterwards in 30 days, fully wash with normal saline, with the sample of cleaning mixture as making smear method counting RBC number and platelet count.
Sample smear and dyeing: draw one of sample droplets in microscope slide one end with the 10ul liquid-transfering gun, move to after pushing away slide and microscope slide keeping 30～45 degree slow and contact drop of blood, when blood scatters suitably apart from (1～1.5cm) along pushing away slide, namely steadily evenly promote forward push jack, make that thickness is suitable, head, body, the clear smear that divides and straight flange is arranged of tail.Drip 2～4 of dye liquors after the smear drying, the full sample of lid is about 10 ~ 30 seconds rapidly.Then drip 3～6 of water recently distilleds, shake gently slide or aim at the smear air blowing, distilled water and dye liquor were fully mixed 30～90 seconds.Wash away dye liquor with flowing water, wait to do for subsequent use.Directly by detecting under 100 times of mirrors, the platelet in 10 visuals field of continuous counter and erythrocytic quantity add up to number as relative number of platelets and mean constant of red blood cell to smear staining.
Testing result is referring to table 2.
Table 2: the anticoagulant effect of isocon before and after processing
| Sample | Relative platelet aggregation number | The red cell |
| Embodiment | ||
| 1 | <2 | <100 |
| |
<2 | <100 |
| Embodiment 3 | ＜2 | <100 |
| |
<1 | <100 |
| |
<3 | <100 |
| Positive control | 10 | >200 |
Table 2 is the result show, obviously reduces through the isocon surface adsorption platelet counts of the present invention's processing and the hemocyte of coagulation, illustrates that its tool surface has anticoagulant functions.
When this isocon uses in reality, dispose on demand puncture needle, with uses such as the tearable catheter sheath of dilator, seal wires.Carry out according to the following steps:
1, in the boring of brain corresponding site, under seal wire supports, the position that intracranial has hydrocrania is inserted in isocon near-end (with a foraminate end) puncture.
2, introduce the lacuna place boring of hydrocrania at needs, under seal wire supports isocon far-end (with an end of valve opening) is inserted lacuna, isocon is embedded in subcutaneous, skin suture gets final product.
If introducing the lacuna of cerebrospinal fluid is venous sinus, need to destroy blood vessel wall with puncture needle, then will insert venous sinus with the catheter sheath of dilator, extract the dilator of catheter sheath the inside out, the drainage tube with seal wire is inserted into venous sinus from catheter sheath, tear catheter sheath, withdraw from seal wire, skin suture.Puncture needle is used for drainage tube and inserts the front puncture to blood vessel of blood vessel, and seal wire is used for the supporting drainage pipe.
Claims (9)
1. multidirectional valve hydrocrania isocon with antibiosis anticoagulative function, as body take a silica gel hose, it is characterized in that, two endcappeds with body, offer several apertures at the sidewall near an end, offer the valve opening that several are offered vertically at the sidewall near another end;
In described body infiltration at least a antibacterials are arranged, and be grafted with anticoagulant at the inside and outside wall of pipe.
2. the multidirectional valve hydrocrania isocon with antibiosis anticoagulative function according to claim 1 is characterized in that, described several apertures are evenly to distribute on the circumferential same cross section of pipe, and between adjacent two cross sections mutual dislocation.
3. the multidirectional valve hydrocrania isocon with antibiosis anticoagulative function according to claim 1 and 2, it is characterized in that, described several valve openings are for axially cutting 2～4 slits establishing along pipe, about length 1cm, these slits upwards evenly distributed in pipe week, and every adjacent two slits are at the tubular axis 1 ± 0.2cm that upwards staggers.
4. the multidirectional valve hydrocrania isocon with antibiosis anticoagulative function according to claim 3 is characterized in that, described several valve openings are at distance adjacent end 0.5～2cm place.
5. according to claim 1 to 4 arbitrary described multidirectional valve hydrocrania isocons with antibiosis anticoagulative function, it is characterized in that the described antibacterials of infiltration are the combination of a kind of in rifampicin and the nitrofural or two kinds.
6. according to claim 1 to 5 arbitrary described multidirectional valve hydrocrania isocons with antibiosis anticoagulative function, it is characterized in that the anticoagulant of grafting is heparin sodium.
7. one kind prepares as having the method for the multidirectional valve hydrocrania isocon of antibiosis anticoagulative function as described in one of claim 1～6, it is characterized in that, comprises the steps:
1) isocon preparation
With silica gel hose two ends end socket rounding, at distance one end 0.5～2cm place, process 2～4 slits, described slit upwards evenly distributes at caliber, and every adjacent two slits upwards stagger about 1cm at tubular axis; Near another end, offer a plurality of apertures, described aperture along pipe circumferentially evenly distribute, mutual dislocation vertically;
2) antimicrobial treatment
Take one of following three kinds of methods:
1. selecting rifampicin is antibacterials, and compound concentration is rifampicin-chloroformic solution of 1～4g/L, and isocon is soaked 5～60min, and the rear first drying of immersion is gone molten, dry again after the washing;
2. selecting nitrofural is antibacterials, and compound concentration is nitrofural-dimethyl sulfoxide solution of 0.1～5g/L, and isocon is soaked 5～60min, and the rear first drying of immersion is gone molten, dry again after the washing;
3. select rifampicin and nitrofural jointly to be antibacterials, first isocon in being rifampicin-chloroformic solution of 1～4g/L, concentration is soaked 5～60mi n, drying is gone molten, after washing again drying, in being nitrofural-dimethyl sulfoxide solution of 0.1～5g/L, concentration soaks 5～60min again, elder generation's drying is gone molten, and is dry again after the washing;
3) anticoagulant is processed
The selection heparin sodium is anticoagulant, and compound concentration is the heparin sodium aqua of 10～100g/L, soaks therein 2～48h with managing the isocon of inside and outside wall through finishing after the antimicrobial treatment, and soaking temperature is 20～40 ℃, and taking-up is dry after soaking.
8. the preparation method with multidirectional valve hydrocrania isocon of antibiosis anticoagulative function according to claim 7, it is characterized in that, described finishing is the plasma sputtering finishing, concrete grammar is: isocon is placed the plasma immersion ion injection device, behind the evacuation, pass into one of hydrogen, nitrogen, steam or ammonia, gas pressure is 0.05～50P; Radio-frequency discharge power is 200～1200W; The pulsed high voltage generator amplitude that loads is 1kV～100kV, and frequency is 50～40000Hz or alternating current power supply 10～20MHz, dutycycle 3%～80%; 20～200 ℃ of heating-up temperatures, the processing time is 0.1～5h.
9. a use is characterized in that as having the method for the multidirectional valve hydrocrania isocon of antibiosis anticoagulative function as described in one of claim 1～6, carries out according to the following steps:
1) in the boring of brain corresponding site, the position that intracranial has hydrocrania is inserted in the foraminate end puncture of isocon band;
2) in the lacuna place boring of needs introducing hydrocrania, with the end insertion lacuna of isocon with the valve opening, get final product drain.
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| CN2012105813146A CN103007422A (en) | 2011-12-29 | 2012-12-27 | Multidirectional valve hydrocephalus shunt valve with antibacterial and anticoagulant functions, and preparation and application method thereof |
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| CN201110450941.1 | 2011-12-29 | ||
| CN201110450941 | 2011-12-29 | ||
| CN2012105813146A CN103007422A (en) | 2011-12-29 | 2012-12-27 | Multidirectional valve hydrocephalus shunt valve with antibacterial and anticoagulant functions, and preparation and application method thereof |
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| CN (2) | CN202982923U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800965A (en) * | 2015-05-21 | 2015-07-29 | 中国人民解放军第二军医大学 | Syringomyelia-subarachnoid space minimal-invasiveness shunting device |
| CN106075707A (en) * | 2016-08-25 | 2016-11-09 | 武正山 | Compound gastrointestinal tract |
| CN110721347A (en) * | 2019-10-14 | 2020-01-24 | 西安市红会医院 | Anti-blocking anti-infection shunt pipe and preparation method thereof |
| CN117258112A (en) * | 2023-11-23 | 2023-12-22 | 南昌康德医院有限公司 | Anti-reflux ureteral stent |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3020913A (en) * | 1958-07-15 | 1962-02-13 | William T Heyer | Surgical drain |
| CN2499039Y (en) * | 2001-09-12 | 2002-07-10 | 刘仍利 | New shunt tube for ventricles of brain and abdominal cavity |
| US20040220510A1 (en) * | 2003-02-18 | 2004-11-04 | Edouard Koullick | Occlusion resistant hydrocephalic shunt |
| CN101987223A (en) * | 2009-07-29 | 2011-03-23 | 山东百多安医疗器械有限公司 | Multi-directional valve peripherally inserted central catheter with anticoagulant and antibacterial functions and preparation method thereof |
-
2012
- 2012-12-27 CN CN2012207363055U patent/CN202982923U/en not_active Expired - Lifetime
- 2012-12-27 CN CN2012105813146A patent/CN103007422A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3020913A (en) * | 1958-07-15 | 1962-02-13 | William T Heyer | Surgical drain |
| CN2499039Y (en) * | 2001-09-12 | 2002-07-10 | 刘仍利 | New shunt tube for ventricles of brain and abdominal cavity |
| US20040220510A1 (en) * | 2003-02-18 | 2004-11-04 | Edouard Koullick | Occlusion resistant hydrocephalic shunt |
| CN101987223A (en) * | 2009-07-29 | 2011-03-23 | 山东百多安医疗器械有限公司 | Multi-directional valve peripherally inserted central catheter with anticoagulant and antibacterial functions and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800965A (en) * | 2015-05-21 | 2015-07-29 | 中国人民解放军第二军医大学 | Syringomyelia-subarachnoid space minimal-invasiveness shunting device |
| CN106075707A (en) * | 2016-08-25 | 2016-11-09 | 武正山 | Compound gastrointestinal tract |
| CN110721347A (en) * | 2019-10-14 | 2020-01-24 | 西安市红会医院 | Anti-blocking anti-infection shunt pipe and preparation method thereof |
| CN117258112A (en) * | 2023-11-23 | 2023-12-22 | 南昌康德医院有限公司 | Anti-reflux ureteral stent |
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| Publication number | Publication date |
|---|---|
| CN202982923U (en) | 2013-06-12 |
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Application publication date: 20130403 |