CN103007359A - Implant for face filling and preparation method thereof - Google Patents
Implant for face filling and preparation method thereof Download PDFInfo
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- CN103007359A CN103007359A CN2012105886698A CN201210588669A CN103007359A CN 103007359 A CN103007359 A CN 103007359A CN 2012105886698 A CN2012105886698 A CN 2012105886698A CN 201210588669 A CN201210588669 A CN 201210588669A CN 103007359 A CN103007359 A CN 103007359A
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- expanded ptfe
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- suspended matter
- filling
- granule
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Abstract
The invention discloses an implant for face filling and a preparation method thereof. The implant for the face filling is a mixed suspended matter prepared by expanded polytetrafluoroethylene particles and a mixture, wherein the expanded polytetrafluoroethylene particles are obtained through the steps of: based on polytetrafluoroethylene as a raw material, expanding via extrusion and stretch, sintering, forming and cutting; the mixture contains sodium hyaluronate gel or botulinum toxin type A; and the mixed suspended matter can also contain antibiotics. The invention also provides the preparation method of the implant for the face filling. The implant for the face filling, prepared by adopting the method, can be implanted by adopting an injection way, is small in wound and convenient for forming, has good biocompatibility and has the advantages that through controlling sizes of micro pores in the expanded polytetrafluoroethylene particles, the histiocyte can grow in and the implant for the face filling can be permanently planted and cannot be absorbed by the body.
Description
Technical field
The present invention relates to a kind of medical implant, belong to medical instruments field; Particularly, relate to a kind of facial implant of filling and preparation method thereof.
Background technology
Be inborn or after human body face depression all badly influence people's global feature.Along with, the raising of living standards of the people, increasing people selects to adopt the mode of operation to reinvent facial characteristics, especially augmentation rhinoplasty operation.Facial soft tissue is filled operation and is divided into two kinds: traditional prosthese implantation and present popular injection system.
The prosthese implantation is still in occupation of certain market, because the effect after the prosthese implantation is more long-range, because injection system, the effect that has can only continue 6 months, and prosthese is implanted, can Permanent implantation such as expanded PTFE.But this mode, operative incision is large, and post-operative complication is many, has increased the misery of operator, and cicatrix is more obvious, affects attractive in appearance.
But over past ten years, injection system more is subject to asking beautiful person's favor.Because this operation is little to patient's wound; The probability of postoperative infection is little, and effect is easy to control, because after the injection, moulding to pinch mode according to patient's demand by hands fully by the doctor moulding.But allow the misgivings of patient's maximum be, the postoperative effect of this injection system can not be lasting, because can be absorbed by the body very soon, needs repeatedly injection, increased financial burden and mental burden.
Summary of the invention
The purpose of this invention is to provide a kind of implant and manufacture method thereof for the face filling, it is lasting that this implant has postoperative effect, and effect is naturally true to nature, the characteristics that operation wound is little.
In order to achieve the above object, the invention provides a kind of facial implant of filling, wherein, the implant that this face is filled is the suspended matter that expanded PTFE granule and intermixture are mixed with.Described expanded PTFE granule is take politef as raw material, through extruding, stretching makes it expanded, carries out the sintering typing again, cuts at last and gets; Described expanded PTFE granule is facial main body of filling implant, and it has good biocompatibility, and has micropore, can grow into by the induced tissue cell, but and Permanent implantation, can not absorbed by health.Described intermixture comprises hyaluronic acid sodium gel or BOTOX, has good lubricity, and can be absorbed by body gradually, is beneficial to the histiocyte expanded PTFE granule of growing into, and reaches the effect of filling.Hyaluronic acid sodium gel has flowability originally as liquid, has served as filler in injection process; Hyaluronic acid sodium gel itself has certain biocompatibility also as the soft tissue filling effect simultaneously.The weight ratio of described intermixture and expanded PTFE granule is 1:1 ~ 1:5.
The implant that above-mentioned face is filled, wherein, the diameter of described expanded PTFE granule is 0.01 ~ 1 mm.
The implant that above-mentioned face is filled, wherein, the micropore size on the described expanded PTFE granule is 20 ~ 50 microns.Histiocyte can be grown into for size by the control micropore, so that this implant can Permanent implantation, sliding transfer can not occur or absorbed by health.
The implant that above-mentioned face is filled, wherein, described suspended matter also comprises antibiotic, can prevent postoperative infection.The percentage ratio that described antibiotic accounts for the suspended matter gross weight is 1% ~ 10%.
The implant that above-mentioned face is filled, wherein, described hyaluronic acid sodium gel, BOTOX and antibiotic become suspended matter with the expanded PTFE granule when producing, perhaps become suspended matter with the expanded PTFE granule in use.
The implant that above-mentioned face is filled, wherein, described suspended matter is implanted by injection in use.
The implant that above-mentioned face is filled, wherein, described suspended matter is preserved under cryogenic conditions.
The present invention also provides a kind of preparation method of facial implant of filling, the method comprises: step 1, mix as the ratio of 20:1 ~ 30:1 according to weight ratio take politef raw material and extrusion aid, under the room temperature, through pushing preforming, form bar-shaped politef, then 40 ~ 100 ℃ of roll-ins, forming diameter is the linear politef of 0.01 ~ 1 mm; Step 2, the linear politef that step 1 is obtained is heated to 300 ℃ ~ 400 ℃ and stretches, and draw ratio is 3 ~ 6 times, makes it expanded, maintains under this temperature, and the sintering typing obtains linear expanded PTFE; Step 3, with the linear expanded PTFE of step 2 gained, cutting into length is the expanded PTFE granule of 0.01 ~ 1 mm; Step 4 is mixed the expanded PTFE granule of step 3 gained to form suspended matter with intermixture, described intermixture comprises hyaluronic acid sodium gel; Step 5 adds antibiotic, cryopreservation in the suspended matter of step 4 gained.
Wherein by the course of processing of control expanded PTFE, make the expanded PTFE granule of gained have suitable density, thereby form uniform and stable suspended matter with the intermixture that comprises hyaluronic acid sodium gel or BOTOX.Concrete draw ratio is larger by the restrained stretching multiple, and micropore is just larger, and the expanded PTFE grain density of gained is just less.
Facial implant of filling provided by the invention has the following advantages:
The implant of filling this face adopts injection system just implantable, and wound is little; Plastotype is convenient, and this implant main part had both had good biocompatibility, had micropore, and the induced tissue cell is grown into, but and Permanent implantation, can not absorbed by health; Intermixture then has good lubricity, and can be absorbed by body gradually, is beneficial to histiocyte and grows into, and reaches the effect of filling.It is more natural in shape after implanting that this face is filled implant, on physiology and all can reach psychologically patient's requirement.
The specific embodiment
Below technical scheme of the present invention is described further.
Facial implant of filling provided by the invention, the suspended matter that is mixed with for expanded PTFE granule and intermixture.
The expanded PTFE granule is take politef as raw material, through extruding, stretching makes it expanded, carries out the sintering typing again, cuts at last and gets.The diameter of expanded PTFE granule is 0.01 ~ 1 mm, and it is facial main body of filling implant, and it has good biocompatibility, and has micropore.Micropore size on the expanded PTFE granule is 20 ~ 50 microns.Histiocyte can be grown into for size by the control micropore, so that this implant can Permanent implantation, sliding transfer can not occur or absorbed by health.Size by the control micropore, (micropore is larger can also to make the expanded PTFE granule of gained have suitable density, the expanded PTFE grain density of gained is just less), thus uniform and stable suspended matter formed with the intermixture that comprises hyaluronic acid sodium gel or BOTOX.
Intermixture adopts hyaluronic acid sodium gel or BOTOX, has good lubricity, and is absorbed by body gradually, is beneficial to the histiocyte expanded PTFE granule of growing into, and reaches the effect of filling.The weight ratio of intermixture and expanded PTFE granule is 1:1 ~ 1:5.Suspended matter also comprises antibiotic, can prevent postoperative infection.The percentage ratio that antibiotic accounts for the suspended matter gross weight is 1% ~ 10%.Hyaluronic acid sodium gel is that commercially available injection is modified hyaluronic acid sodium gel, and employed antibiotic mainly is penicillins, such as benzylpenicillin, and cephalo-type.
Intermixture becomes suspended matter with the expanded PTFE granule when producing, perhaps become suspended matter with the expanded PTFE granule in use.
This suspended matter is preserved under cryogenic conditions, implants by injection in use.。
The present invention also provides the preparation method of the implant of facial filling, and the method comprises:
Step 1 is the ratio mixing of 20:1 ~ 30:1 with the lubricated crowded oil (mineral spirits solvent is provided by Exxon chemical company) that helps according to weight ratio with the politef raw material, makes it to mix with oscillator to reach even.Then, at room temperature, through pushing (pressure is 10 ~ 30 tons) preforming, form bar-shaped politef, adopt the twin shaft roll squeezer 40 ~ 100 ℃ of roll-ins, the rotating speed of principal and subordinate's roller is 1:1 ~ 1:5, and forming diameter is the linear politef of 0.01 ~ 1 mm.
Step 2, the linear politef that step 1 is obtained is heated to 300 ~ 400 ℃, adopt the biaxial stretching machine to stretch, draw ratio is 3 ~ 6 times (draw ratio is larger, and micropore is just larger), make it expanded, produce a large amount of " joint and fiber " structures, its aperture is about 20 ~ 50 microns, maintains under this temperature, sintering typing 3 hours obtains linear expanded PTFE.
Step 3, with the linear expanded PTFE of step 2 gained, cutting into length is the expanded PTFE granule of 0.01 ~ 1 mm.
Step 4 is mixed the expanded PTFE granule of step 3 gained to form suspended matter with intermixture, intermixture comprises hyaluronic acid sodium gel or BOTOX.The weight ratio of intermixture and expanded PTFE granule is 1:1 ~ 1:5.
Step 5 adds antibiotic, cryopreservation in the suspended matter of step 4 gained.The percentage ratio that antibiotic accounts for the suspended matter gross weight is 1% ~ 10%, mainly adopts Penicillin antibiotics.
Facial implant of filling provided by the invention adopts injection system just implantable, and postoperative effect is lasting, and plastotype is convenient, and effect is naturally true to nature, and operation wound is little, on physiology and the psychological requirement that all can reach the patient.This implant main part had both had good biocompatibility, had micropore, and the induced tissue cell is grown into, but and Permanent implantation, can not absorbed by health; Intermixture then has good lubricity, and can be absorbed by body gradually, is beneficial to histiocyte and grows into, and reaches the effect of filling.
Although content of the present invention has been done detailed introduction by above preferred embodiment, will be appreciated that above-mentioned description should not be considered to limitation of the present invention.After those skilled in the art have read foregoing, for multiple modification of the present invention with to substitute all will be apparent.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (8)
1. a facial implant of filling is characterized in that the implant that this face is filled is the suspended matter that expanded PTFE granule and intermixture are mixed with;
Described expanded PTFE granule is take politef as raw material, through extruding, stretching makes it expanded, carries out the sintering typing again, cuts at last and gets;
Described intermixture comprises hyaluronic acid sodium gel or BOTOX, and the weight ratio of described intermixture and expanded PTFE granule is 1:1 ~ 1:5.
2. facial implant of filling as claimed in claim 1 is characterized in that the diameter of described expanded PTFE granule is 0.01 ~ 1 mm.
3. facial implant of filling as claimed in claim 2 is characterized in that the micropore size on the described expanded PTFE granule is 20 ~ 50 microns.
4. facial implant of filling as claimed in claim 1 is characterized in that also comprise antibiotic in the described suspended matter, the percentage ratio that described antibiotic accounts for the suspended matter gross weight is 1% ~ 10%.
5. facial implant of filling as claimed in claim 4, it is characterized in that, described hyaluronic acid sodium gel or BOTOX and antibiotic become suspended matter with the expanded PTFE granule when producing, perhaps become suspended matter with the expanded PTFE granule in use.
6. facial implant of filling as claimed in claim 5 is characterized in that described suspended matter is implanted by injection in use.
7. facial implant of filling as claimed in claim 6 is characterized in that described suspended matter is preserved under cryogenic conditions.
8. the preparation method of the described facial implant of filling of a claim 1 ~ 7 is characterized in that the method comprises:
Step 1 is mixed as the ratio of 20:1 ~ 30:1 according to weight ratio take politef raw material and extrusion aid, under the room temperature, through pushing preforming, form bar-shaped politef, then 40 ~ 100 ℃ of roll-ins, forming diameter is the linear politef of 0.01 ~ 1 mm;
Step 2, the linear politef that step 1 is obtained is heated to 300 ℃ ~ 400 ℃ and stretches, and draw ratio is 3 ~ 6 times, makes it expanded, maintains under this temperature, and the sintering typing obtains linear expanded PTFE;
Step 3, with the linear expanded PTFE of step 2 gained, cutting into length is the expanded PTFE granule of 0.01 ~ 1 mm;
Step 4 is mixed the expanded PTFE granule of step 3 gained to form suspended matter with intermixture, described intermixture comprise hyaluronic acid sodium gel and or BOTOX;
Step 5 adds antibiotic, cryopreservation in the suspended matter of step 4 gained.
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| CN2012105886698A CN103007359A (en) | 2012-12-29 | 2012-12-29 | Implant for face filling and preparation method thereof |
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| CN2012105886698A CN103007359A (en) | 2012-12-29 | 2012-12-29 | Implant for face filling and preparation method thereof |
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| CN103007359A true CN103007359A (en) | 2013-04-03 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251046A (en) * | 2015-09-25 | 2016-01-20 | 苏州蔻美新材料有限公司 | Facial filling material, and preparation method thereof |
| CN106421897A (en) * | 2016-10-26 | 2017-02-22 | 曹京敏 | Human body soft tissue filling agent and preparation method thereof and specialized pulverizer |
| CN108653818A (en) * | 2018-05-24 | 2018-10-16 | 上海其胜生物制剂有限公司 | A kind of reversible collagen stimulation filler and preparation method thereof |
| CN111375084A (en) * | 2018-12-29 | 2020-07-07 | 上海索康医用材料有限公司 | Tissue patch and preparation method thereof |
| CN112996456A (en) * | 2018-11-06 | 2021-06-18 | 胶囊护理有限责任公司 | Capsule device for enclosing a body organ or mass and use thereof |
| CN114134606A (en) * | 2021-12-09 | 2022-03-04 | 常州蓝烁环保科技有限公司 | Polytetrafluoroethylene bulked yarn and preparation method of textile prepared from same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251046A (en) * | 2015-09-25 | 2016-01-20 | 苏州蔻美新材料有限公司 | Facial filling material, and preparation method thereof |
| CN106421897A (en) * | 2016-10-26 | 2017-02-22 | 曹京敏 | Human body soft tissue filling agent and preparation method thereof and specialized pulverizer |
| CN108653818A (en) * | 2018-05-24 | 2018-10-16 | 上海其胜生物制剂有限公司 | A kind of reversible collagen stimulation filler and preparation method thereof |
| CN112996456A (en) * | 2018-11-06 | 2021-06-18 | 胶囊护理有限责任公司 | Capsule device for enclosing a body organ or mass and use thereof |
| CN111375084A (en) * | 2018-12-29 | 2020-07-07 | 上海索康医用材料有限公司 | Tissue patch and preparation method thereof |
| CN114134606A (en) * | 2021-12-09 | 2022-03-04 | 常州蓝烁环保科技有限公司 | Polytetrafluoroethylene bulked yarn and preparation method of textile prepared from same |
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Application publication date: 20130403 |