CN103006200A - Wireless detection device of small animals action potential - Google Patents
Wireless detection device of small animals action potential Download PDFInfo
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- CN103006200A CN103006200A CN2012105666895A CN201210566689A CN103006200A CN 103006200 A CN103006200 A CN 103006200A CN 2012105666895 A CN2012105666895 A CN 2012105666895A CN 201210566689 A CN201210566689 A CN 201210566689A CN 103006200 A CN103006200 A CN 103006200A
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Abstract
The invention discloses a wireless detection device of a small animals action potential. The device is characterized by comprising a front end and a rear end which are in wireless connection with each other, wherein the front end is temporarily and fixedly arranged on the small animals; the front end is formed by a signal amplifying module, a signal frequency modulation module and a direct current power supply module which is used for supplying power for the two modules; a micro electrode implanted into mice is taken as an input signal of the signal amplifying module; and an amplified mouse action potential signal enters into the signal frequency modulation module to be modulated, and is radiated by an external transmitting antenna; and the distance between the rear end and the front end is not more than 2.5m, the rear end is a signal demodulation module, and the mouse action potential signal subjected to frequency modulation enters into the demodulation module by an external receiving antenna, and then is radiated and output to a computer to be processed and analyzed.
Description
Technical field
The present invention relates to a kind of checkout gear of behavior of animal current potential, particularly the checkout gear of the toy action potential such as a kind of mice.
Background technology
The action potential actual state of surveying on the electricity that shows that is excitability cell (such as neuron and myocyte) before and after functionating also is the window that dynamic biochemical event that cell occurs on molecular level is granted a preciousness of research worker.By the formation mechanism of research action current potential, the biochemical reaction on the dynamic molecular level that occurs in the time of can further understanding the cell functionating.Every field in life sciences has all run into all insoluble problems of some original theories at present, this research that forms mechanism is expected to promote the new development of whole life science theory.Can grasp its mechanism by studying mechanism, reach the purpose that promotes the medical skill development in practical application, many difficult miscellaneous diseases are expected to obtain cure, such as the treatment of anesthesia and delayed ischemic neurological deficits.
Zoopery is human obtain the new knowledge of the aspects such as related biological, medical science or deal with problems and the scientific research of using animal to carry out in laboratory.Animal commonly used comprises monkey, pig, Canis familiaris L., rat, mice and Bufo siccus etc., and the mechanism of production of the action potential by studying these animals can provide scientific basis for the diagnosis and treatment that the mankind explore disease.
The checkout gear of related animal action potential becomes study hotspot at home and abroad.At present, the checkout gear of behavior of animal current potential mainly adopts implant electrode to insert detected part, then processes through front end signals such as amplifications, filtering, through the cable connection action potential signal is transferred in the acquisition and processing software of rear end to analyze.In whole testing process, owing to adopt cable to connect between the front-end and back-end, the freely-movable of detected animal is restricted, and directly affects objectivity and the accuracy of measuring; And these checkout gear volumes and weight are larger, are not suitable for the toy such as mice, Bufo siccus of small volume.
Summary of the invention
The purpose of this invention is to provide and a kind of toy (mice, Bufo siccus etc.) action potential is carried out the device of radio detection, realize the non-contact detecting of its action potential.
For reaching above purpose, the present invention takes following technical scheme to be achieved:
A kind of wireless detection device of toy action potential, it is characterized in that, the front-end and back-end two parts that comprise wireless connections, wherein front end is temporarily fixed on it the toy, consist of by signal amplification module, signal frequency modulation module and for the DC power supplier of these two module for power supply, implant the interior microelectrode of Mice Body as the input signal of signal amplification module, the mice action potential entering signal frequency modulation module after amplifying is modulated, is radiated by an external transmitting antenna again; The distance of described rear end and front end is no more than 2.5m, is a signal demodulation module, is entered this demodulation module by the mice action potential signal behind the frequency modulation by an external reception antenna and exports to computer after demodulated and carry out Treatment Analysis.
In the such scheme, described signal amplification module is made of integrated instrument amplifier and a plurality of resistor network of single power supply, and the circuit amplification is 980.Described signal frequency modulation module is made of the LC FM circuit, and its carrier frequency is 85MHz-108MHz.Described DC power supplier is made of button cell and power supply stabilization circuit.Described signal demodulation module is made of an integrated frequency-modulated device, a plurality of external capacitor, and by the demodulation of external reception antenna realization 85MHz-108MHz FM signal, and the reference frequency output of the signal after demodulated is 5Hz-3.6kHz.
Compare with existing mice action potential checkout gear, the present invention has the following advantages:
1, do not affect the freely movable of mice: owing to adopt the wireless frequency modulation pattern, need not mice is connected with back-end processing connects with connecting wire, can make mice its action potential of detection under freely movable condition.
2, little, lightweight, the low price of volume: in signal amplification, modulation and three modules of power supply except the components and parts the inductance all adopt the Surface Mount form, so volume is little; Battery adopts micro button cell, so that front end (being comprised of signal amplification, modulation and the power module) gross weight that detects transposition is therefore lightweight less than 10g; Used components and parts mostly are greatly conventional device, and are therefore cheap.
3, the frequency response of output signal is good after the demodulation: the signal demodulation module has been owing to adopted the extraordinary special IC of frequency response, can make the output signal after its demodulation reach 5Hz-3.6kHz by external capacitor, contained the frequency response of mice action potential fully.
4, the suitability is strong: except the action potential that is applicable to the radio detection mice, also can be used for the detection of the animal related neural current potential of the larger builds such as rat, rabbit, have the stronger suitability.
Description of drawings
The present invention is described in further detail below in conjunction with accompanying drawing and the specific embodiment.
Fig. 1 is the functional block diagram of checkout gear of the present invention.Among the figure: in connects the input of signal amplification module for implanting miniature electrode output signal in the Mice Body; Tan1 is transmitting antenna; Tan2 is reception antenna; Out is the action potential signal of output.
Fig. 2 is the circuit theory diagrams of front end in Fig. 1 checkout gear.
Fig. 3 is the circuit theory diagrams of rear end in Fig. 1 checkout gear.
Fig. 4 is for adopting checkout gear of the present invention to detect the action potential signal of mice.Wherein (a) figure is the action potential signal of emission, and (b) figure is the action potential signal after the demodulation.
The specific embodiment
As shown in Figure 1, a kind of wireless detection device of mice action potential comprises that temporary fixed (be, paste or binding) separate the rear end that is no more than 2.5m in it front end of tested mice, with front end.Wherein front end comprises a signal amplification module, a signal frequency modulation module and is the DC power supplier of these two module for power supply; The rear end is a signal demodulation module.Implant the interior microelectrode of Mice Body as the input signal of signal amplification module
InThrough being amplified into signal frequency modulation module, mice action potential after the amplification is modulated through this signal frequency modulation module, be radiated through external transmitting antenna E1, by the mice action potential behind the frequency modulation, by behind the signal demodulation module of rear end, output mice action potential signal is to computer by external reception antenna E2.The present invention realizes the radio detection of mice action potential by two parts in front-end and back-end and external emission, reception antenna E1, E2.
The physical circuit of Fig. 1 checkout gear front end can adopt structure as shown in Figure 2.Wherein signal amplification circuit is AD627 by integrated instrument amplifier U1(model), resistance R 1, R2, Rg and capacitor C 0 form, single supply+3.3V power (being provided by power module) is provided, the fixed partial pressure circuit that R1 and R2 form is as the reference voltage of instrument amplifier, its gain determines that by Rg (the Rg value is 205 ohm, the actual amplification that records is 980), 0 pair of dc source of capacitor C carries out filtering.The signal FM circuit is 2SC1359 by high frequency transistor Q1(model), LC resonance circuit and electric source filter circuit form, wherein the LC resonance circuit is comprised of inductance L 1, capacitor C 5 and variable capacitance C6, by regulating the value of C6, can realize that the reference carrier frequency of frequency modulation reaches 85MHz-108MHz; Electric source filter circuit is by inductance L 2 and capacitor C 1, and C2 forms, and the ground with signal amplification and FM circuit when the 3.3V DC voltage is carried out filtering isolates, and realizes the isolation of low frequency and high-frequency circuit; Connect by coupling capacitance C3 between signal amplification and the signal FM circuit.DC power supplier is LIR1632 by 3.6V chargeable lithium ion button cell Vin(model, capacity 120mAh, weight 1.8g) and mu balanced circuit form, mu balanced circuit is G914D by integrated regulator U2(model) and capacitor C in, Cb, Cout form, output voltage is 3.3V.Except inductance L 1, L2 and transistor Q1, other components and parts all adopt the Surface Mount form, and the mice field potential behind the frequency modulation or action potential radiate through transmitting antenna E1.The hardware weight of whole front end is less than 10g.
The physical circuit of Fig. 1 checkout gear rear end can adopt structure as shown in Figure 3.Reception antenna E2 receives mice field potential or the action potential behind the frequency modulation, extracts mice field potential or action potential through behind the signal demodulating circuit.Signal demodulating circuit is TDA7010T by integrated frequency-modulated device U1(model) and external capacitor C 1-C14, Cp and Cs, inductance L 1 and L2, resistance R 1 and variable capacitance Cv form.Wherein by regulating variable capacitance Cv value, can be worth in full accord with carrier frequency in the FM circuit; It is 4 passive bandpass filters that the radio frequency operation frequency of demodulator circuit forms quality factor by capacitor C 9, C10 and inductance L 1, L2, and its frequency range is for being 85MHz-108MHz; The frequency range of the output signal of demodulation determines that by the resistance of capacitor C 5-C8 electric capacity and IC interior its frequency range can reach 5Hz-3.6kHz, contains the frequency range of mice field potential and action potential fully.Power acquisition is powered with external+5V.
Adopt the mice action potential wireless detection device of present embodiment, external 2 collapsible mast and+dc source of 5V after, detect a mice action potential waveform as shown in Figure 4.Distance between reception antenna and the transmitting antenna is 2.5 meters, and the rear end of device (demodulator circuit) need not any cable with front end and be connected, can be freely movable the testing process mice.
Claims (5)
1. the wireless detection device of a toy action potential, it is characterized in that, the front-end and back-end two parts that comprise wireless connections, wherein front end is temporarily fixed on it the toy, consist of by signal amplification module, signal frequency modulation module and for the DC power supplier of these two module for power supply, implant the interior microelectrode of Mice Body as the input signal of signal amplification module, the mice action potential entering signal frequency modulation module after amplifying is modulated, is radiated by an external transmitting antenna again; The distance of described rear end and front end is no more than 2.5m, is a signal demodulation module, is entered this demodulation module by the mice action potential signal behind the frequency modulation by an external reception antenna and exports to computer after demodulated and carry out Treatment Analysis.
2. the wireless detection device of toy action potential as claimed in claim 1 is characterized in that, described signal amplification module is made of integrated instrument amplifier and a plurality of resistor network of single power supply, and the circuit amplification is 980.
3. the wireless detection device of toy action potential as claimed in claim 1 is characterized in that, described signal frequency modulation module is made of the LC FM circuit, and its carrier frequency is 85MHz-108MHz.
4. the wireless detection device of toy action potential as claimed in claim 1 is characterized in that, described DC power supplier is made of button cell and power supply stabilization circuit.
5. the wireless detection device of toy action potential as claimed in claim 1, it is characterized in that, described signal demodulation module is made of an integrated frequency-modulated device, a plurality of external capacitor, by the demodulation of external reception antenna realization 85MHz-108MHz FM signal, and the reference frequency output of the signal after demodulated is 5Hz-3.6kHz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105666895A CN103006200A (en) | 2012-12-24 | 2012-12-24 | Wireless detection device of small animals action potential |
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| CN2012105666895A CN103006200A (en) | 2012-12-24 | 2012-12-24 | Wireless detection device of small animals action potential |
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| CN103006200A true CN103006200A (en) | 2013-04-03 |
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| CN2012105666895A Pending CN103006200A (en) | 2012-12-24 | 2012-12-24 | Wireless detection device of small animals action potential |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2059576U (en) * | 1989-07-12 | 1990-07-25 | 吕历明 | Separated type electrocardiogram machine capable of transmitting by telephone network |
| CN2216391Y (en) * | 1995-04-28 | 1996-01-03 | 清华大学 | Digital remote-controlling micro-cardioelectric monitoring instrument |
| US6026321A (en) * | 1997-04-02 | 2000-02-15 | Suzuki Motor Corporation | Apparatus and system for measuring electrical potential variations in human body |
| JP2010269082A (en) * | 2009-05-25 | 2010-12-02 | Olympus Corp | Medical wireless telemeter system |
| CN102499686A (en) * | 2011-10-31 | 2012-06-20 | 中国人民解放军第四军医大学 | Wireless monitoring device for infant apnea |
-
2012
- 2012-12-24 CN CN2012105666895A patent/CN103006200A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2059576U (en) * | 1989-07-12 | 1990-07-25 | 吕历明 | Separated type electrocardiogram machine capable of transmitting by telephone network |
| CN2216391Y (en) * | 1995-04-28 | 1996-01-03 | 清华大学 | Digital remote-controlling micro-cardioelectric monitoring instrument |
| US6026321A (en) * | 1997-04-02 | 2000-02-15 | Suzuki Motor Corporation | Apparatus and system for measuring electrical potential variations in human body |
| JP2010269082A (en) * | 2009-05-25 | 2010-12-02 | Olympus Corp | Medical wireless telemeter system |
| CN102499686A (en) * | 2011-10-31 | 2012-06-20 | 中国人民解放军第四军医大学 | Wireless monitoring device for infant apnea |
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Application publication date: 20130403 |