CN103002839B - Adjusting the fluid distribution system - Google Patents

Adjusting the fluid distribution system Download PDF

Info

Publication number
CN103002839B
CN103002839B CN201080068040.XA CN201080068040A CN103002839B CN 103002839 B CN103002839 B CN 103002839B CN 201080068040 A CN201080068040 A CN 201080068040A CN 103002839 B CN103002839 B CN 103002839B
Authority
CN
China
Prior art keywords
bile
valve
means
control signal
system
Prior art date
Application number
CN201080068040.XA
Other languages
Chinese (zh)
Other versions
CN103002839A (en
Inventor
M·弗雷德
F·比洛蒂
M·加尔瓦奥内托
M·S·奥尔蒂茨
A·帕斯托雷利
T·E·亚尔布雷彻特
C·J·赫斯
M·J·斯托克斯
M·S·齐纳
Original Assignee
伊西康内外科公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 伊西康内外科公司 filed Critical 伊西康内外科公司
Priority to PCT/EP2010/060273 priority Critical patent/WO2012007046A1/en
Publication of CN103002839A publication Critical patent/CN103002839A/en
Application granted granted Critical
Publication of CN103002839B publication Critical patent/CN103002839B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/0076Implantable devices or invasive measures preventing normal digestion, e.g. Bariatric or gastric sleeves

Abstract

本发明公开了一种用于调节体液分配的系统(11),所述系统(11)包括调节阀(12)和生理特性感测装置(13),所述调节阀(12)能够放置在体液的流动通道中,所述生理特性感测装置(13)与所述调节阀(12)信号连通并且能够根据所述生理特性生成控制信号(14),其中所述调节阀(12)能够响应所述控制信号(14)来改变所述体液的流速。 The present invention discloses a system (11) for adjusting the distribution of body fluids, said system (11) comprising a regulator valve (12) and physiological sensing means Laid (13), the regulator valve (12) can be placed in a body fluid flow passage, said sensing physiological Laid means (13) and the regulating valve (12) capable of generating a control signal and the communication signal (14) in accordance with the physiological characteristics, wherein said control valve (12) capable of response said control signal (14) to change the flow rate of the fluid.

Description

调节体液分配的系统 Adjusting the fluid distribution system

技术领域 FIELD

[0001] 本发明整体涉及如下装置和方法,所述装置和方法用于外科手术性地改变器官和血管以影响患者的消化,由此来治疗代谢性疾病例如病态肥胖症以及相关的并存病,例如糖尿病、心脏病、中风、肺疾病、和偶发病症。 [0001] The present invention generally relates to apparatus and method, the apparatus and method for the surgical and vascular surgery changes to affect the digestive organs of a patient, thereby treating metabolic disorders such as obesity and morbid associated comorbidities, such as diabetes, heart disease, stroke, lung disease, and sporadic disorders.

背景技术 Background technique

[0002] 已经尝试过许多实质上不具有永久性成功的治疗病态肥胖症的非手术疗法。 [0002]'ve tried a number of non-surgical treatment of morbid obesity have virtually no permanent success.

[0003] 治疗病态肥胖症的外科手术方法,例如针对持久性食物吸收不良的开放式、腹腔镜式、和腔内胃旁路手术已得到日益广泛的应用并且获得了较大成功。 [0003] surgical methods for the treatment of morbid obesity, such as an open, laparoscopic and endoluminal gastric bypass surgery for persistent malabsorption of food has been increasingly widely used and gained great success. 然而,目前用于执行胃旁路术的方法涉及耗时的和高灵敏度依赖性的外科手术技术以及患者的胃肠解剖结构的显著且通常不可取的修改。 However, a method for performing gastric bypass time-consuming and involves high sensitivity dependence surgical techniques and often undesirable and significant changes in the patient's anatomy parenterally.

[0004] 为了避免胃旁路手术的缺点并且以更具体且有针对性的方式来影响患者的消化, 本发明着重研究用于主要影响和修改肠-肝胆汁循环而非消化道的方法和装置。 [0004] In order to avoid the disadvantages of gastric bypass surgery and more specific and targeted way to digest the patient's influence, the present invention focuses on a main influence and modify gut - of liver and biliary tract, rather than circulating means . 为此,应当设想到作用于肠-肝胆汁循环的下述可能方法和机制: For this purpose, it is contemplated that in the intestinal - the following possible ways and mechanisms of hepatic bile cycle:

[0005]-修改肠-肝胆汁循环频率,尤其是胆汁循环加速度; [0005] - Modify the intestine - liver bile cycle frequency, in particular, bile acceleration cycle;

[0006]-修改由胆汁与肠内的食物的接触和相互作用以及由胆汁与肠壁的接触触发的生理信号; [0006] - Modify the physiological signal is triggered by the contact and interaction with the food, bile and intestinal bile into contact with the intestinal wall;

[0007]-通过修改胆汁与肠内的食物或食糜之间的接触空间和接触时间以及通过使胆汁从食物有针对性地分离来修改食物吸收能力。 [0007] - by modifying the contact between the contact time and spatial bile and intestinal chyme and modifying food or food absorption capacity by the bile targeted separated from food.

[0008] 本发明的特定目标为提供如下方法和装置,所述方法和装置用于调节体液,尤其是胆胰液的分配,例如以尤其微创的方式来有针对性地影响和调节消化。 [0008] The specific object of the present invention to provide a method and apparatus, a method and apparatus for adjusting the body fluid, in particular assigned bile pancreatic juice, for example, in particular minimally invasive manner to influence in a targeted manner and that modulates digestion.

[0009] 临床实验已表明,将食物引入空肠内的时间和将胆胰液引入空肠内的时间以及使它们混合和相互作用的时间可导致重量损失和/或允许控制糖尿病。 [0009] Clinical trials have shown that the food will be introduced into the bile and pancreatic juice time within the time of introduction and mixing them jejunum and interaction time may result in weight loss and / or allow control of diabetes in the jejunum. 因此,需要将胆汁与食糜的混合延缓到胃肠道中的较低点或者阻止胆汁与胃肠道相互作用直至达到较远侧位置才排放胆汁并且允许混合。 Thus, mixing of bile with the chyme need to slow to a lower point in the gastrointestinal tract or prevent the interaction of bile and gastrointestinal tract more distal position until the discharge of bile and was allowed to mix.

[0010] 用于将消化分泌物(例如,胆汁和胰分泌物)向远侧转移到小肠内的已知装置和方法已在US2009/0062717和US7, 314, 489中有所论述。 [0010] for the digestive secretions (e.g., bile and pancreatic secretions) to the known devices and methods within the small intestine has US2009 / 0062717 and US7, 314, 489 are discussed in the distally. 公开于US7, 314, 489中的装置包括支架,所述支架具有远端、和接合乏特壶腹区域中的十二指肠的近端、以及位于近端和远端之间以产生可收集胆汁的环形体积的减小的直径部分。 Disclosed in US7, apparatus 314, 489 includes a bracket having a distal end, a proximal end and a lack of engagement Laid ampulla region of the duodenum, and to produce a collector positioned between the proximal and distal ends a reduced diameter portion of the annular volume of bile. 公开于US2009/0062717中的装置包括支承架和导管,所述支承架具有侧面开口,所述导管在与侧面开口连接的近端与远侧开口端之间延伸,其中所述导管的近端可形成贮存器。 Apparatus disclosed in US2009 / 0062717 comprises a support frame and a catheter, said support frame having a lateral opening, said conduit extending between a proximal end connected to the open end side of the distal opening, wherein the proximal end of the catheter may be the reservoir is formed.

[0011] 用于转移消化分泌物的已知装置和方法收集胆汁,但它们不响应特定的生理特性而主动地调节的胆汁的分配时间。 Known apparatus and methods of the digestive secretions [0011] for transferring the collected bile, but they do not respond to particular physiological characteristic allocation time actively adjusted bile.

[0012] 因此,本发明的另一个目标为根据与穿过胃肠道的食物摄入和食物通道相关的患者机体的生理特性来修改将胆胰液引入到胃肠道内的时间。 [0012] Accordingly, another object of the present invention to be modified according to the physiological characteristics of the patient's body through the gastrointestinal tract associated with food intake and food passage time into bile pancreatic juice in the gastrointestinal tract.

发明内容 SUMMARY

[0013] 通过用于调节体液分配的系统来实现这些目标,所述系统包括能够放置在体液的流动通道中的调节阀以及与调节阀信号连通的生理特性感测装置,其中得自生理特性感测装置的信号可引起阀来改变体液的流速。 [0013] By adjusting the fluid dispensing system used to achieve these goals, the system comprising a body fluid in the flow channel can be placed in the control valve and the regulator valve means sensing physiological Laid communication signals, wherein from a physiological Laid sexy signal sensing means may cause the valve to vary the flow rate of the fluid. 体液可为胆汁或胰液并且生理特性可为身体的一部分中的流体例如胃内容物的pH值或pH值变化。 Fluid may be bile and pancreatic juice or physiological characteristics may be part of the body fluid, such as changes in pH or pH value of the gastric contents.

[0014] 另外通过用于调节体液分配的方法来实现上述目标,所述方法包括以下步骤: [0014] Further by the method for adjusting the distribution of body fluids to achieve the above object, the method comprising the steps of:

[0015] _将调节阀放置在患者体内的体液的流动通道中的第一位置处; [0015] _ to adjust the position of the valve at a first fluid disposed in the flow path of the patient;

[0016]-将感测装置放置在体内的第二位置处;以及 [0016] - the sensing device is placed at a second location in the body; and

[0017]-感测第二位置的生理特性;以及根据感测的生理特性生成控制信号;以及 [0017] - sensing a second physiological characteristic position; and generating a control signal based on the sensed physiological characteristic; and

[0018] _将控制信号提供到阀以调节体液的流速。 [0018] _ a control signal to the valve to adjust the fluid flow rate.

[0019] 根据本发明的一个方面,提供了用于调节胆胰液的流速的方法,所述方法包括以下步骤: [0019] In accordance with one aspect of the invention, there is provided a method for adjusting the flow rate of bile pancreatic juice, said method comprising the steps of:

[0020] -将主动调节阀放置在胆胰液的流动通道中;以及 [0020] - The driving adjustment valve disposed in the flow path of the bile pancreatic juice; and

[0021] -将pH传感器放置在胃中;以及 [0021] - a pH sensor is placed in the stomach; and

[0022] -感测胃内容物的pH;以及 [0022] - pH sensing stomach contents; and

[0023]-根据感测的pH生成控制信号;以及 [0023] - generating a control signal based on the sensed pH; and

[0024]-将控制信号发送到阀并且利用得自控制信号的信息来调节胆胰液的流速。 [0024] - a control signal is transmitted to the valve and synthesized using control information signal to adjust the flow rate of bile pancreatic juice.

[0025] 这使得在无需侵入性外科手术或显著改变患者的解剖结构的情况下来影响代谢作用机制成为可能。 [0025] This mechanism makes the influence metabolism without invasive surgery or significant change in the patient's anatomy down becomes possible.

[0026] 根据本发明的另一个方面,提供了用于改变患者的消化的外科手术方法,所述方法包括以下步骤: [0026] According to another aspect of the present invention, there is provided a surgical method for changing the digested patient, said method comprising the steps of:

[0027]-将支架经口放置成与位于胆胰液的流动通道上的第一位置处的主动调节阀流体连通; [0027] - the stent is placed orally active regulator valve in fluid communication at a first location on the pancreatic juice and bile flow channel is located;

[0028]-将pH传感器连接到胃内的位置处;以及 The pH sensor at the connection position into the stomach - [0028]; and

[0029]-将支架锚固在胃肠道的一部分内,从而增加支架对于作用在支架上的蠕动力的抗性。 [0029] - anchoring the stent in a portion of the gastrointestinal tract, thereby increasing the resistance to creep holder force acting on the stent.

附图说明 BRIEF DESCRIPTION

[0030] 通过附图及其说明,本发明的这些和其它目的和优点将变得明显,所述附图及其说明示出了本发明的实施例,并连同上面给出的本发明的整体描述以及下文给出的实施例的具体实施方式用于解释本发明的原理。 [0030] The description and the drawings These and other objects and advantages of the invention will become apparent from the accompanying drawings and the description thereof illustrate an embodiment of the present invention, and the present invention is given above in conjunction with the entire DETAILED dESCRIPTION Example embodiments given below, serve to explain and describe the principles of the present invention.

[0031]-图1示出了根据本发明的第一实施例的用于调节患者体内的胆胰液的流速的方法和装置; [0031] - Figure 1 shows a flow of a method and apparatus bile pancreatic juice according to the first embodiment of the embodiment of the present invention for regulating a patient;

[0032]-图2为用于图1的方法中的胆汁收集装置的示意性剖视图; [0032] - Figure 2 is a schematic cross-sectional view of the method of the bile collection device of FIG. 1 for;

[0033]-图3示出了根据本发明的第二实施例的用于调节患者体内的胆胰液的流速的方法和装置; [0033] - Figure 3 illustrates a method and apparatus pancreatic bile flow rate according to a second embodiment of the present invention for regulating a patient;

[0034]-图4示出了根据本发明的第三实施例的用于将胆汁收集装置锚固在胃肠道中的装置和方法; [0034] - Figure 4 shows an apparatus and method for anchoring the collecting means bile in the gastrointestinal tract according to a third embodiment of the present invention;

[0035]-图5示出了根据本发明的第四实施例的用于将胆汁收集装置锚固在胃肠道中的装置和方法; [0035] - Figure 5 shows an apparatus and method for anchoring the collecting means bile in the gastrointestinal tract according to a fourth embodiment of the present invention;

[0036]-图6示出了根据本发明的第五实施例的用于将胆汁收集装置锚固在胃肠道中的装置和方法; [0036] - Figure 6 shows an apparatus and method for collecting the bile in the gastrointestinal tract anchoring device according to a fifth embodiment of the present invention;

[0037]-图7示出了根据本发明的第六实施例的用于将胆汁收集装置锚固在胃肠道中的装置和方法; [0037] - Figure 7 shows an apparatus and method for collecting the bile in the gastrointestinal tract anchoring device according to the sixth embodiment of the present invention;

[0038]-图8和8A示出了根据本发明的第七实施例的用于将胆汁收集装置锚固在胃肠道中的装置和方法; [0038] - Figures 8 and 8A illustrate an apparatus and method for collecting the bile in the gastrointestinal tract anchoring device according to the seventh embodiment of the present invention;

[0039] -图9、9A至9C示出了根据本发明的第八实施例的用于将胆汁收集装置锚固在胃肠道中的装置和方法步骤; [0039] - Figures 9,9A to 9C show method steps and apparatus bile collection device anchored in the gastrointestinal tract according to an eighth embodiment of the present invention;

[0040] -图10示出了根据本发明的实施例的具有主动控制阀的体液储存袋; [0040] - Figure 10 shows a fluid control valve active storage bag according to an embodiment of the present invention has;

[0041] -图11和12为根据本发明的实施例的调节系统的控制系统的示意图; [0041] - Figures 11 and 12 the control system according to an embodiment of the control system of the present invention; and FIG.

[0042]-图13和14为根据本发明的实施例的调节阀装置的示意性剖视图; [0042] - Figure 13 and 14 are schematic cross-sectional view of a control valve unit of the embodiment of the present invention;

具体实施方式 Detailed ways

[0043] 参见附图,其中在若干视图中类似的数字代表类似的解剖结构和部件,图1为患者的腹腔的局部视图,示出了具有食道1、胃2、十二指肠3、空肠4、回肠5、结肠6的胃肠道、 以及具有肝脏、包含胆囊8的胆道系统7、胰管9、和乏特壶腹的十二指肠大乳头10 (胆汁和胰液穿过其正常地进入十二指肠3)的肝胆系统、以及用于调节体液分配的系统11。 [0043] Referring to the drawings, wherein like numerals in the several views similar anatomical structures and components, FIG. 1 is a partial view of a patient's abdominal cavity, the esophagus is shown having 1, 2 stomach, duodenum 3, jejunum 4, 5 ileum, colon, gastrointestinal 6, and a liver, gallbladder biliary system comprising 8 7 9 pancreatic duct, ampulla of Vater and the duodenal papilla 10 (through the bile and pancreatic juice which normally 3 into the duodenum) of the hepatobiliary system, and a system 11 for adjusting the distribution of body fluids.

[0044] 根据实施例,系统11包括流速调节阀12和生理特性感测装置13,所述流速调节阀12能够被放置在体液的流动通道中,所述生理特性感测装置13与调节阀12信号连通并且能够根据生理特性生成控制信号14,其中调节阀12响应控制信号14改变体液的流速。 [0044] According to an embodiment, the system 11 includes a flow rate adjusting valve 12 and the physiological sensing means Laid-13, the flow rate adjusting valve 12 can be placed in a bodily fluid flow passage, said sensing means Laid physiological regulator valve 13 and 12 communication signals and can generate a control signal 14 in accordance with the physiological characteristics, wherein the regulator valve 12 in response to a control signal 14 to change the flow rate of the fluid.

[0045] 根据本发明的一个方面,体液可为胆汁和或胰液,并且生理特性可为身体的一部分中的流体(例如胃内容物)的pH值或pH变化值和/或温度值或温度变化值。 [0045] In accordance with one aspect of the invention, the body fluid may be bile and or pancreatic juice, and physiological characteristics may be a portion of the fluid of the body (e.g., gastric contents) pH or a shift in pH and / or temperature values ​​or temperature change value.

[0046] 牛理特件感测装詈的实施例的详细描沐 [0046] Detailed description of embodiments of bovine Mu processing apparatus sensing member Laid Dirty

[0047] 在示例性实施例中,生理特性感测装置13可包括pH传感器18,所述pH传感器18 能够被放置和锚固在患者体内,尤其是在胃2中,并且能够根据胃内容物的pH值或pH变化值生成pH控制信号14并将pH控制信号14直接传输到调节阀12的随载控制器15或者作为另外一种选择传输到远程控制单元16。 [0047] In an exemplary embodiment, the physiological sensing means 13 may Laid include a pH sensor 18, the pH sensor 18 and the anchor can be placed in the patient, especially in the stomach 2, and according to contents of the stomach can be pH or pH variation value generator 14 and pH control pH control signals 14 transmitted directly to the adjustment valve 12 with the onboard controller 15, or alternatively transmitted to the remote control unit 16.

[0048] 生理特性感测装置13还可包括温度传感器19 (其可与pH传感器18机械地分离或机械地连接),所述温度传感器19能够被放置和锚固在患者体内,尤其是在胃2中,并且能够根据胃内容物的温度或温度变化生成温度控制信号并将温度控制信号14直接传输到调节阀12的随载控制器15或者作为另外一种选择传输到远程控制单元16。 [0048] Patent physiological sensing means 13 may also include a temperature sensor 19 (which may be separate from the pH sensor 18 is mechanically or mechanically connected), the temperature sensor 19 can be positioned and anchored in the patient, especially in the stomach 2 , and the temperature can be generated according to the temperature or temperature change of the stomach contents and the temperature control signal 14 is directly transmitted control signal with the onboard controller to adjust the valve 15 or 12 is alternatively transmitted to the remote control unit 16.

[0049] 可在生理特性感测装置13上提供无线电信号发射器20以用于无线传输控制信号14〇 [0049] to provide a radio signal transmitter 20 for wireless transmission of control signals in a physiologically 14〇 Laid sensing means 13

[0050] 根据实施例,生理特性感测装置13包括用于给感测功能以及控制信号生成和传输提供能量的可充电随载电池21,并且还包括无线随载电池充电器22,例如,将超声波或磁脉冲转换为电能以对电池21再充电的超声或感应充电器。 [0050] According to an embodiment, the physiological sensing means 13 comprises Laid for providing energy to the sensing function and the control signal generated and transmitted with the rechargeable battery 21 is contained, and further comprising a wireless carrier with a battery charger 22, for example, ultrasound or magnetic pulses into electrical energy to recharge the 21 ultrasonic or inductive charger for the battery.

[0051] 作为非限制性实例,生理特性感测装置13可包括可得自MedtronicFunctional Diagnostics(Minneapolis,Minnesota,USA)的Bravo®无线pH胶囊传感器。 [0051] By way of non-limiting example, Patent physiological sensing means 13 may comprise available from MedtronicFunctional Diagnostics (Minneapolis, Minnesota, USA) pH of Bravo® wireless sensor capsule.

[0052] 将生理特性感测装置13优选地结合到单个经口或经鼻插入式胶囊中,所述胶囊连接到远侧食道或胃壁并且将pH数据通过无线电遥测术传输到远程控制单元16或直接传输到调节阀12的随载控制器15。 [0052] 13 is preferably Laid physiological sensing device incorporated into a single orally or nasally inserted into the capsules, the capsule is connected to the distal esophagus or stomach and the pH telemetry data transmitted by radio to the remote control unit 16 or transmitted directly to the regulating valve 12 with on-board controller 15.

[0053] 可将感测装置13胶囊连接在递送导管的末端处并且穿过口或鼻直到其到达期望位置,例如在内窥镜测量的Z线上方约6cm处。 [0053] The sensing device 13 may be connected to the capsule at the end of the delivery catheter and through the mouth or nose until it reaches a desired position, for example at about 6cm Z endoscope MA measured. 定位之后,将感测装置13永久性地或临时性地连接到食道或胃壁。 After the positioning, the sensing device 13 permanently or temporarily connected to the stomach or esophagus. 然后移除递送导管。 The delivery catheter is then removed. 当患者在内窥镜检查期间镇静时或者当患者在食管测压之后清醒时,可执行口服置入。 When the patient sedation during an endoscopic or when the patient is awake after esophageal manometry performed oral placement.

[0054] 就例如通过吸取对感测装置13的临时性固定而言,其类似于上述BRAVOpH探针的固定,但后者不需要随载电池充电器并且将在7到14天范围的时间段内下降并传送到粪便中。 [0054] For example, for temporary fixing by suction the sensing means 13, which is similar to the above-described BRAVOpH fixed probe, but the latter does not require a battery charger and the carrier with the period of 7-14 days in a range in the fall and transferred to the feces. 感测装置13可以或不可以回收和再使用。 The sensing device 13 may or may not be recovered and reused.

[0055] 此外,可将生理特性感测装置13结合到胶囊中,所述胶囊可按照类似于丸剂的方式进行吞咽并且具有用于自动地对接到先前植入的胶囊捕获装置的对接接口。 [0055] Further, Patent physiological sensing means 13 is coupled to the capsule, the capsule may be swallowed pill similar manner and having a docking interface for automatically docked the previously implanted capsule capture device. 对接接口和胶囊捕获装置的可能实施例在例如美国专利申请US2010/0063486、US2010/0056874、US 2010/0049120、US2010/0049012、US2009/0306632中有所公开,这些专利申请涉及诊断性丸剂捕获系统并且它们的全部内容均以引用方式并入本文。 Docking interface and capsules capture device may, for example, in the embodiment of U.S. Patent Application US2010 / 0063486, US2010 / 0056874, US 2010/0049120, US2010 / 0049012, in US2009 / 0306632 are disclosed, these patent applications relates to diagnostic and pills capturing system entire contents of which are incorporated herein by reference.

[0056] 就感测装置13的永久性固定而言,随载电池应为可无线再充电的。 For permanently fixed [0056] to the sensing device 13, the battery should be contained with the wireless recharging.

[0057] 在一个实施例中,生理特性感测装置13可被构造为牙齿植入物并且能够感测患者的口腔中的pH值或pH变化值。 [0057] In one embodiment, the physiological Laid sensing means 13 may be configured as a dental implant and is able to sense changes in pH or pH value measured in a patient's mouth. 此实施例提供了感测装置的简单植入、维护和更换,且无需任何外科手术或内窥镜手术。 This embodiment provides a simple implantable sensing device, maintenance and replacement, without requiring any surgical or endoscopic surgery.

[0058] 调节阀的实施例的详细描沐 [0058] Example embodiments detailed description Mu regulating valve

[0059] 调节阀12可包括机电或电磁阀致动器26、流体通道27、和闸门构件28,所述机电或电磁阀致动器26由随载式阀控制器15控制,所述闸门构件28从内部(图13)或外部(图14)作用在流体通道27上并且可通过阀致动器26而在打开位置和关闭位置之间运动, 闸门构件28在所述打开位置释放流体通道27以使得体液可自由地流过通道27,闸门构件28在所述关闭位置接合流体通道27,从而将其关闭。 [0059] The regulator valve 12 may include a solenoid or electromechanical actuator 26, fluid passage 27, and the shutter member 28, the electromechanical or solenoid valve 15 controls the actuator 26 with the valve controlled by the carrier, the shutter member 28 from the inside (FIG. 13) or external (FIG. 14) while in action and may move between an open position and a closed position, the shutter member 28 releasing the fluid passage in the open position in the fluid passage 27 through valve actuator 26 27 such that fluid can flow freely through the passage 27, the shutter member 28 in the closed position engaging the fluid passage 27, so as to close said.

[0060] 在图13的示例性实施例中,调节阀12为球形阀,所述球形阀具有能够分别释放和阻塞流体通道27的内部闸门构件28。 [0060] In the exemplary embodiment of FIG. 13, control valve 12 is a ball valve, a ball valve 28 having an inner shutter member capable of releasing and blocking the fluid passage 27, respectively.

[0061] 图14示出了可供选择的实施例,其中调节阀12包括弹性流体通道管27以及能够分别释放和压缩流体通道27的弹性部分的外部闸门构件29。 [0061] FIG 14 illustrates an alternative embodiment in which the regulator valve 12 includes a resilient fluid tube 27 and an outer passage the shutter member 29 can be released and the compressed resilient portion of the fluid passage 27, respectively.

[0062] 调节阀12的这两个图示实施例均允许体液在其打开构型中基本无阻力地流动, 这对于胆汁和胰液的可控排放是必需的,因为它们的自然分泌物是在不存在显著压力的情况下产生的。 [0062] Example 12 illustrates that two regulating valves are body fluids, in its open configuration substantially no resistance to flow, for which a controlled discharge of bile and pancreatic juice is necessary, because in their natural secretions produced in the absence of significant pressure.

[0063] 系统棹制器的实施例的详细描沐 [0063] Detailed description of embodiments of the systems Zhao Mu system's

[0064] 根据实施例,远程控制单元16具有传感器控制信号接收器23、程控信号解析单元24 (如,微处理器)、和阀控制信号发射器25,并且能够从pH传感器13接收控制信号14、并且能够根据接收到的控制信号14和加载到信号解析单元24的存储器中的阀控制程序生成阀控制信号17、并能够将阀控制信号14传输到调节阀12的随载控制器15。 [0064] According to an embodiment, the control unit 16 has a sensor remote control signal receiver 23, a programmable signal analysis means 24 (e.g., a microprocessor), and a valve control signal transmitter 25, and 13 can be a control signal received from the pH sensor 14 and is capable of receiving a control signal to a control valve 14 and loaded into the program memory of the signal analysis means 24 generates a valve control signal 17 and the control valve can be adjusted with the transmission signal 14 to the board controller 15 of the valve 12.

[0065] 远程控制单元16能够与电池充电器22相配合,尤其能够生成可通过电池充电器22转换成电能以对电池21再充电的超声波或磁脉冲。 [0065] The remote control unit 16 to electrical energy can be engaged with the battery charger 22, in particular, can be generated can be converted by the battery charger 22 to recharge the battery ultrasound or magnetic pulse 21.

[0066] 在控制信号14从感测装置13直接传输到调节阀12的情况下,阀12的随载控制器15可具有控制信号接收器30和程控信号解析单元31,例如微处理器,并且能够从pH传感器13接收控制信号14并根据接收到的控制信号14和加载到信号解析单元31的存储器中的阀控制程序来启动阀致动器26。 [0066] In the case where the control signal 14 is transmitted directly from sensing device 13 to the regulator valve 12, a valve controller 12 with the carrier 15 may have a control signal receiver unit 30 and a programmable signal analyzer 31, such as a microprocessor, and control signal can be received from the pH sensor 13 and 14 to actuate the valve actuator 26 in accordance with a control signal received by the memory 14 and loaded into the signal analyzing unit 31 in valve control program.

[0067] 通常,随载式阀控制器15或远程控制单元16能够从提供生理特性(例如,患者的胃2的内容物的pH和/或温度)的感测装置13接收控制信号14,并且可操作阀致动器26 以调整流体通道27的流动截面。 [0067] Generally, the carrier with the control valve 15 or 13 can be a remote control unit 16 receives a control signal 14 provided from the physiological characteristics (e.g., the stomach contents of the patient 2 pH and / or temperature) of the sensing means, and valve actuator 26 is operable to adjust the flow section of the fluid channel 27.

[0068] 在一个示例性实施例中,随载式阀控制器15或远程控制单元16的信号解析单元被构造和程控以用于将所测量的生理特性值与预定的目标值进行比较。 [0068] In one exemplary embodiment, the control valve 15 with the carrier signal analysis means or the remote control unit 16 is configured and programmed physiological characteristic values ​​for the measured and predetermined target values. 例如,如果传感器装置包括pH传感器或温度传感器,则信号解析单元24, 31能够将传感器装置13检测到的pH或温度与预定的目标pH或温度进行比较。 For example, if the sensor means comprise a temperature sensor or a pH sensor, the signal analysis unit 24, 31 can be detected by the sensor device 13 pH or temperature of a predetermined target pH or temperature are compared.

[0069] 为了有利于比较,随载式阀控制器15或远程控制单元16的信号解析单元可被构造为接收表示目标值的输入信号。 [0069] In order to facilitate comparison, with the signal analysis unit carrier control valve 15 or the remote control unit 16 may be configured to receive an input signal representing a target value. 除了比较数值之外,随载式阀控制器15或远程控制单元16的信号解析单元可被程控用于根据一系列随后接收到的控制信号14和时间信息来计算生理特性的变化。 In addition to comparing values, with the signal analysis unit carrier control valve 15 or the remote control unit 16 may be programmed to calculate the change in the physiological characteristic according to the sequence of control signal 14 and the subsequently received time information.

[0070] 随载式阀控制器15或远程控制单元16的信号解析单元还可被程控用于计算调节阀12的期望的流体通道27流动截面以实现体液的目标流速。 [0070] with the carrier signal analysis unit 15 or the remote control valve 16 of the control unit 27 may be programmed regulating the flow cross sections of the valve 12 the desired fluid channel for the fluid flow rate to achieve the goal.

[0071] 用于调节体液的分配和流速的系统11还可包括外部程控装置32,所述外部程控装置32与随载式阀控制器15或远程控制单元16的信号解析单元24, 31连通并且可整合到体外远程控制单元16中。 [0071] and for adjusting the flow rate of the fluid dispensing system 11 may further comprise means external programmer 32, the external apparatus 32 and communicates with the program control and signal analysis unit carrier control valve 15 or 24 of the remote control unit 16, 31 It may be integrated into a remote control unit 16 in vitro.

[0072] 通常,程控装置32可包括用户界面,所述用户界面允许操作者输入一个或更多个指令以传送到随载式阀控制器15或远程控制单元16的信号解析单元24, 31。 [0072] Generally, program-controlled device 32 may include a user interface, the user interface allows the operator to enter one or more instructions to transmit to the control valve 15 with the carrier or the remote control unit 24 of the signal analysis means 16, 31. 例如,外部程控装置32能够将表示患者的胃内容物的pH变化或温度的预定目标值的信号、以及表示相对于流过胃肠道的食物而言的期望的胆汁释放延迟时间或胆汁释放提前时间的信号传输到信号解析单元24, 31。 For example, the external device 32 can be programmed to a predetermined target value representing a change in pH or temperature of the stomach contents of the patient signal and representing a desired relative release of bile flowing in terms of the gastrointestinal tract or bile food early release time delay signal propagation time to the signal analysis means 24, 31. 外部程控装置32可包括用于将信息(例如预定体液分配调节方案的参数、测量的生理特性、低电量警示)传送给用户的显示元件。 External programmer device 32 may include a display information element (e.g. a body fluid dispensing a predetermined adjustment program parameters, physiological characteristics measured, a low battery warning) to the user.

[0073] 如此前所述,根据示例性实施例,植入式生理特性感测装置13、阀控制器15、远程控制单元16 (如果提供)、和外部程控装置32可被构造为通过射频(RF)通信来通信。 [0073] As previously described, according to an exemplary embodiment, an implantable physiological Laid sensing means 13, valve controller 15, the remote control unit 16 (if provided), and the external programmer device 32 may be configured as a radio frequency ( RF) communication to communicate. 为此目的,感测装置13、阀控制器15、远程控制单元16 (如果提供)、和外部程控装置32可包括可被构造为在彼此间发送和/或接收信号的信号发射器和接收器或天线。 For this purpose, the sensing means 13, valve controller 15, the remote control unit 16 (if provided), and the external programmer device 32 may be configured to include the transmission between each other and / or the signal transmitter and the signal received by the receiver or antenna. 这种通信允许调节阀致动器26的非侵入性控制。 Such communication allows the non-invasive regulation control valve actuator 26. 天线可具有多种构造,并且可被设置在系统11中的多个位置处。 The antenna can have a variety of configurations, and may be provided at a plurality of locations in the system 11. 例如,在一个示例性实施例中,控制器15和与其相关的天线均可被设置在植入式调节阀12上。 For example, in one exemplary embodiment, the antenna 15 and associated controller can be disposed on the implantable regulating valve 12. 在另一个实施例中,控制器15可包括在植入式调节阀12内,而天线可被布置在单独的植入物上。 In another embodiment, the controller 15 may include a valve 12 in an implantable adjustment, the antenna may be disposed on a separate implant. 在另一个示例性实施例中,外部控制单元16和与其相关的天线均可被布置为与调节阀12分离。 In another exemplary embodiment, the external control unit 16 and its associated antenna can be arranged to be separated from the regulating valve 12.

[0074] 在一个实施例中,阀控制器15或远程控制单元16被构造和程控以响应pH变化控制信号14来操作阀致动器26以关闭调节阀12,所述pH变化控制信号指示食物被引入到胃2内,从而将胆汁和/或胰液聚积在流动通道中而不流入消化道(此时食物向远侧穿行到小肠内)。 [0074] In one embodiment, the valve controller 15 or the remote control unit 16 is configured and programmed to respond to pH changes in the control signal 14 to operate the valve actuator 26 to close the regulator valve 12, a control signal indicative of the pH change of food 2 is introduced into the stomach, so that the bile and / or pancreatic juice accumulation in the flow channel without flowing into the digestive tract (in this case walking distally food into the small intestine).

[0075] 在另一个实施例中,阀控制器15或远程控制单元16可被构造和程控以响应pH变化控制信号14来操作阀致动器26以打开调节阀12,所述pH变化控制信号指示食物已离开胃2并且进一步被传送到消化道的更远侧,从而在相对于食物从胃穿行到小肠中的特定时延之后将胆汁和/或胰液分配到消化道内。 26 to open the regulator valve 12 embodiment, the valve controller 15 or the remote control unit 16 may be configured and programmed to respond to pH changes in the control signal 14 to operate the valve actuator [0075] In another embodiment, the pH change control signal 2 indicates the food has left the stomach and is further transmitted to a more distal digestive tract, so that with respect to the food after walking from the stomach into the small intestine bile specific delay and / or assigned to the pancreatic juice in the digestive tract.

[0076] 在另一个示例性实施例中,阀控制器15或远程控制单元16可被构造和程控以将pH和/或温度控制信号14或信号14序列与存储的参考值进行比较以识别出食物已进入胃2中的时间点以及食物已从胃2穿行到肠内的时间点。 [0076] In another exemplary embodiment, the valve controller 15 or the remote control unit 16 may be configured and programmed to the pH and / or temperature control signal 14 or signal 14 with the stored sequence of reference value to identify food has entered the stomach in the 2:00 time, and the food from the stomach to walk through the 2 time points intestine.

[0077] 此外,阀控制器15或远程控制单元16可被构造和程控以根据食物进入胃的时间点和食物进入肠的时间点以及存储的时间参考曲线或参考值来外推食物或食糜流在胃肠道中的位置。 [0077] In addition, the valve controller 15 or the remote control unit 16 may be configured and programmed in accordance with the food into the stomach into the intestine time point and a time point the food and the storage of the reference time or reference value or extrapolation food chyme flow position in the gastrointestinal tract.

[0078] 随载式阀控制器15或远程控制单元16可被程控以根据食物在胃肠道中的位置以及食物传送到如空肠内和分配胆胰液之间的预置提前时间间隔和/或延迟时间间隔来启动打开和/或关闭和/或调节调节阀12的流动截面。 [0078] A load control valve 15 or the remote control unit 16 may be programmed to transfer to the food in the gastrointestinal tract in accordance with the position and foods such as pre-allocation between the bile and pancreatic juice jejunum time interval advance and / or delay time interval starting opening and / or closing and / or regulating the flow regulating valve 12 cross-section.

[0079] 所述流动调节方法和装置可根据患者的独特生理条件进行校正并且可获得重量减轻和控制糖尿病的有利效果。 [0079] The flow conditioning method and apparatus can be corrected based on the unique physiological condition of the patient and the weight reduction and control of diabetes obtained advantageous effects.

[0080] 根据实施例,系统11可包括胆汁收集装置33或支架,所述胆汁收集装置33和支架能够被锚固在小肠中,尤其是在十二指肠3中的胆胰液通常进入肠的乏特乳头10处,并且能够捕集胆胰液并将其引导到调节阀12的流体通道27中。 [0080] According to an embodiment, the system 11 may comprise a bile collection device or stent 33, the stent and bile collection means 33 can be anchored in the small intestine, bile pancreatic juice in the duodenum especially 3 generally lack into the intestine Laid nipple 10, and capable of trapping bile and pancreatic juice guided to the regulator valve fluid passageway 27 12.

[0081] 3曰汁收集装詈的实施例的详细描沐 Mu detailed description of embodiments of the [0081] 3 curse of said juice collection device

[0082] 在示例性实施例中,胆汁收集装置33包括管状食物通道槽34以及侧向开放式胆汁收集腔37,所述管状食物通道槽34具有能够接纳通过肠蠕动传送的食物流的优选漏斗形近侧开口端35和能够将食物从槽34向远侧释放到肠内的优选漏斗形远侧开口端36,所述侧向开放式胆汁收集腔37与食物通道槽34隔离并且能够与肠壁的相邻部分一起限定基本上密封的胆汁收集室38。 [0082] In an exemplary embodiment, the bile collection means 33 comprises a tubular food passage groove 34 and open laterally bile collection chamber 37, the groove 34 having a tubular passage of food through the food capable of receiving the transmitted stream is preferably funnel peristalsis shaped end 35 and a proximal opening can be released into the intestine the food distally from the groove 34 is preferably funnel-shaped end of the distal opening 36, the open side of the collection chamber 37 is isolated from the bile passage groove 34 and the food can be gut adjacent portions of the wall together define a substantially sealed chamber 38 to collect bile.

[0083] 根据图1和2所示的示例性、非限制性实施例,胆汁收集腔37包括径向外部环形腔,所述径向外部环形腔围绕食物通道槽34形成并且在轴向上由径向突出的近侧管腔密封部分39和远侧管腔密封部分40设定界限。 [0083] According to FIGS. 1 and 2 shown in the exemplary, non-limiting embodiment, the bile collection chamber 37 includes a radially outer annular chamber, said radially outer annular chamber around the food passageway by the grooves 34 formed in the axial direction and a radially projecting sealing portion 39 and the proximal lumen lumen distal sealing portion 40 to set boundaries.

[0084] 管腔密封部分39,40优选可从初始伸缩的径向较小构型膨胀,以便允许将胆汁收集装置33经腔(例如经口)引入和传送到乏特乳头10处的所选十二指肠部分并且通过膨胀管腔密封部分39,40来完成其后续部署。 [0084] Preferably the lumen of the sealing portion 39, 40 may be retractable from an initial expanded radially smaller configuration so as to allow a bile collection means 33 via the chamber (e.g. oral) is introduced and transmitted to the lack of the nipple 10 is selected Laid part of the duodenum and to complete its subsequent deployment of the sealing portion 39, 40 through the inflation lumen.

[0085] 为此,管腔密封部分39,40可包括可膨胀式球囊节段,所述可膨胀式球囊节段可通过注入膨胀流体(例如盐水溶液)、或固化膨胀剂(例如硬化聚合物泡沫或糊剂)而永久性地膨胀。 [0085] To this end, the lumen of the sealing portion 39, 40 may comprise an inflatable balloon section, the inflatable balloon expandable segments by injecting a fluid (e.g. saline solution), bulking agents or curing (hardening e.g. polymer foam or paste) permanently expanded.

[0086] 根据实施例,近侧管腔密封部分39还可限定胆汁通道孔41,所述胆汁通道孔41通入胆汁收集腔37并且通往胆汁导管42,例如导管,所述胆汁导管42可被连接以用于产生与食物和食糜隔离并且也与肠壁隔离的胆汁流动通道。 [0086] According to an embodiment, the lumen of the proximal portion 39 also defines a sealed passage hole 41 of bile, the bile passage holes 41 into collection chamber 37 and the bile duct 42 leading to the bile, such as catheters, catheter 42 may be the bile It is connected for producing the food and chyme also isolated and isolated intestinal bile flow channel.

[0087] 在示例性实施例中,胆汁导管42包括在近侧开口端和远侧开口端之间延伸的柔性管,其中近侧开口端与胆汁收集腔37的内部流体连接,并且远侧开口端可被定位在胆汁收集装置33更远侧的肠内,如图1和2所示。 [0087] In an exemplary embodiment, the bile duct 42 includes a proximal open end and a flexible tube extending between a distal open end, wherein the proximal open end of the internal fluid and bile collection chamber 37 is connected, and the distal opening end may be positioned more distal intestine in bile collection means 33, shown in Figures 1 and 2.

[0088] 调节阀12可与胆汁收集装置33或胆汁导管42流体连接以控制从中穿过的胆汁流速。 [0088] The regulator valve 12 may be connected to control the bile flow 42 therethrough in fluid collection apparatus 33 or a bile duct and bile.

[0089] 在示例性实施例中,调节阀12可被放置在胆汁导管42的远侧开口端附近,从而提供位于胆汁导管42内的额外的胆汁积聚空间。 [0089] In an exemplary embodiment, the regulator valve 12 may be disposed at the distal end of the bile duct in the vicinity of the opening 42, to provide additional accumulation of bile bile duct is located within the space 42. 在可供选择的示例性实施例中,调节阀12 可被放置在胆汁导管42的近侧开口端附近或其中心区内。 In an alternative embodiment of the exemplary embodiment, the regulator valve 12 may be disposed at the proximal open end of the bile duct 42 or near the center in the region.

[0090] 鉴于胆汁收集装置33的上述特征,使在不存在食糜接触的情况下以及在未用导管接触极其精细的胆道系统7的情况下收集胆胰液成为可能。 [0090] In view of the above features bile collection device 33, so that in the case where no contact exists chyme bile pancreatic juice was collected in the absence of extremely fine catheter in contact with the biliary tree and 7 becomes possible.

[0091] 参照图1和图2的实施例,胆汁收集室38是通过下述方式产生的:在内窥镜的辅助下将胆汁收集装置33 (仍处于其初始伸缩构型)和连接的胆汁导管42 (如果提供)经口递送到乏特壶腹10的位置,随后通过膨胀其管腔密封部分39,40来部署胆汁收集装置33。 [0091] Referring to FIGS. 1 and Examples, bile collection chamber 38 is generated in the following manner in FIG. 2: with the aid of an endoscope bile collection means 33 (still in its initial telescoping configuration) and connected to bile conduit 42 (if provided) to the oral delivery position ampulla of Vater 10, followed by the expansion of its lumen 39, 40 to the sealing portion 33 deployed bile collection means.

[0092] 在另一个示例性实施例中,胆汁收集装置可包括Laufer的美国专利申请2009/0062717中所述类型的支架,该专利申请的内容以引用方式并入本文。 [0092] In another exemplary embodiment, the collection means may comprise a bile Laufer U.S. Patent Application 2009/0062717 in the types of stents, the contents of which patent application is incorporated herein by reference.

[0093] 根据图10所示的可供选择的实施例,用于调节体液11的分配的系统可包括储存袋59、胆汁引流导管60、以及胆汁分配导管61,所述储存袋59用于聚积和保持胆胰液,所述胆汁引流导管60可为引入胆总管7的针并且在能够固定在胆道系统7中的近侧开口端和与储存袋59的近侧入口孔连接的远侧开口端之间延伸,以使得将胆汁直接从胆道系统引流到储存袋59中,所述胆汁分配导管61将储存袋59的远侧出口孔与调节阀12以及(如果提供)体液栗系统连接。 [0093] According to an alternative embodiment shown in FIG. 10, for regulating the fluid dispensing system 11 may include a storage bag 59, biliary drainage catheter 60, and bile distribution conduit 61, the reservoir bag 59 for accumulating bile and pancreatic juice remains, the biliary drainage catheter 60 may be introduced into the bile duct 7 and the needle can be fixed in the proximal open end 7 in the biliary system is connected with the proximal and distal inlet aperture 59 of the storage bag open end of extends between, so that the direct drainage of bile from the bile duct system to the storage bag 59, the dispensing conduit 61 to reservoir bile distal exit aperture 59 of the bag 12 and the control valve (if provided) Li fluid system connection.

[0094] 根据示例性实施例,储存袋59可包括可膨胀式球囊,使得胆汁可排入其内并使其膨胀以供储存直到需要时(即,直到通过pH控制阀启动进行分配时)。 [0094] According to an exemplary embodiment, the storage bag 59 may comprise an inflatable balloon, so that bile may be discharged and allowed to swell therein for storage until needed (i.e., until the valve control start time assigned by pH) . 球囊自身可由PET加工。 The balloon itself may be PET processing.

[0095] 根据又另一个实施例,储存袋59可包括刚性外壁62以充当用于限定胆汁储存空间的柔性的可膨胀式内壁63的保护装置。 [0095] According to yet another embodiment, the storage bag 59 may include a rigid outer wall 62 to act as a protection device may be an inflatable inner wall 63 for defining a storage space bile flexible.

[0096] 根据另一个实施例,体液排出溢流阀或排出溢流栗可被提供并且可能地集成到调节阀12中,并且当达到最大体液储存容量时能够允许所聚积体液的一部分排到肠内。 [0096] According to another embodiment, the body fluid discharged spill or overflow discharge Li may be provided and may be integrated into the regulator valve 12, and reaches a maximum when the storage capacity capable of allowing the fluid portion of bodily fluid discharged into the intestinal accumulation Inside.

[0097] 用于阳汁收集装詈和调节阀的锚固装詈的实施例的详细描沐 Mu Detailed description [0097] The means for collecting the juice male and Dirty Dirty controller of the embodiment of the anchoring means of the valve

[0098] 根据本发明的另一个方面,系统11可包括在漏斗形近侧开口端44和远侧开口端45之间延伸的第一套管43(示于图1中),所述漏斗形近侧开口端44能够例如通过与幽门适形连接而锚固在胃2内,所述远侧开口端45连接到胆汁收集装置33的近侧孔35。 [0098] According to another aspect of the invention, the system 11 may include a funnel-shaped proximal opening 44 and a first end of the sleeve 43 extending between a distal end opening 45 (shown in FIG. 1), said funnel the proximal end 44 can be open, for example by suitable shaped connection pyloric anchored in the stomach 2, the distal opening 45 is connected to the proximal aperture bile collecting apparatus 3533 ends. 第一套管43可锚固胆汁收集装置33以较好地对抗蠕动力,并且可收集容纳在胃2内的食物并将其引导到食物通道槽34内而不接触肠壁。 The first sleeve 43 can be anchored to the bile collection means 33 preferably against peristalsis, and can be collected in the stomach housed 2 and directed into the food without touching the food passage groove 34 wall.

[0099] 在示例性的非限制性实施例中,第二套管64可从胆汁收集装置33的远侧开口端36向远侧延伸,以将食糜或部分消化的食物与肠壁隔离,而同时胆汁导管42导管可将胆胰液与肠壁和食糜隔离(对照图2)。 [0099] In an exemplary non-limiting embodiment, the second sleeve 64 from the distal bile collection device 33 open end 36 extends distally to the chyme or partially digested food and isolation wall, the bile duct 42 while the conduit may be bile and pancreatic juice and intestinal digesta isolation (FIG. 2 control).

[0100] 作为另外一种选择或除此之外,为了抵抗作用在装置33,42,12的蠕动力,可例如通过胃线圈46将这些装置锚固在胃肠道内,所述胃线圈46可从延展构型(能够将其经口或经鼻传送到胃2内)弹性变形为旋拧弓形或圆形构型(能够适形地接合胃2以便对连接到胆汁收集装置33的近端的锚固线提供锚固)(图3)。 [0100] Alternatively or in addition, against the action of a peristaltic force to the means 33,42,12, 46 may, for example, these anchoring means within the gastrointestinal tract, the stomach through the gastric coil from the coil 46 extended configuration (which can be transmitted orally or nasally into the stomach 2) screwed to the elastically deformable arcuate or circular configuration (to conform to the stomach 2 to engage the proximal end of the anchoring means 33 is connected to the collector of a bile providing an anchor line) (FIG. 3).

[0101] 在一个实施例中,生理特性感测装置13可容纳在胃线圈46中或连接到胃线圈46, 由此使其能够可靠地固定在胃2中。 [0101] In one embodiment, the physiological Laid sensing means 13 can be accommodated in the stomach or the coil 46 is connected to the coil 46 of the stomach, thereby making it possible to reliably fixed to 2 in the stomach.

[0102] 在图4所示的另一个示例性实施例中,可例如通过T形箍将锚固线47连接到先前在胃壁中形成的折襞48。 [0102] In another exemplary embodiment illustrated in FIG. 4, for example, may be connected to the 47 previously formed in the stomach wall by a T-shaped anchor line plication band 48.

[0103] 在图5所示的另一个示例性实施例中,可通过粘膜下带49将胆汁收集装置33锚固到肠壁,所述粘膜下带49插入到管腔壁中并且完全环绕其延伸,例如形成锚固环以在肠壁中产生瓶颈部分,所述瓶颈部分能够接合形成于胆汁收集装置33的管腔密封部分39,40 中的至少一个内的相应环状锚固凹槽50。 [0103] In another exemplary embodiment illustrated in FIG. 5, band 49 by submucosal bile collection device 33 is anchored to the wall, the band 49 is inserted into the mucosal lumen wall and extending completely around the , for example, a ring to produce a neck portion of the anchor in the intestinal wall, said neck portion to engage the respective annular anchoring recess 50 is formed within the lumen of the at least one bile collection means 33 sealing portion 39, 40.

[0104] 图6示出了又另一个示例性实施例,其中可通过胃支架51和连接的可弹性膨胀式(可能地形状记忆)弓52将胆汁收集装置33锚固在胃肠道中,所述弓52能够与胃2形成适形连接。 [0104] FIG 6 illustrates yet another exemplary embodiment, wherein the bracket 51 through the stomach and the elastic expansion (possibly the shape memory) 52 will bow anchor bile collection device 33 connected in the gastrointestinal tract, the bow 52 can be connected to form a conformal 2 stomach.

[0105] 图7示出了另一个示例性实施例,其中可通过T形箍53将胆汁收集装置33锚固在胃肠道中,所述T形箍53从肠内击送到肠壁中,从而形成固定点并且与胆汁收集装置33 的近端连接。 [0105] FIG. 7 shows another exemplary embodiment wherein the cuff 53 through a T-shaped collection means 33 anchoring the bile in the gastrointestinal tract, the T-shaped ferrule from the intestinal wall 53 to strike, thereby forming a fixed point and connected to the proximal end of the bile collection device 33.

[0106] 图8和8A示出了另一个示例性实施例,其中可通过具有多个锚固倒钩55的环状锚固部件54将胆汁收集装置33锚固在胃肠道中,所述倒钩55可从静止位置运动(如,旋转)到工作位置,倒钩55在所述静止位置容纳在锚固部分54的范围内以允许装置33的无阻挡腔内传送,倒钩55在所述工作位置径向向外凸出,从而刺穿管腔壁并因而将装置33锚固到管腔壁。 [0106] FIGS. 8 and 8A illustrate another exemplary embodiment, wherein the anchoring member 54 annular barb 55 having a plurality of anchoring by the anchoring bile collection means 33 in the gastrointestinal tract, the barbs 55 may from a rest position (e.g., rotation) to the working position, the barbs 55 in the rest position of the receiving section 54 in a range to allow for transluminal delivery device 33 without blocking the barbs 55 radially in the working position the anchor projecting outwardly, thereby piercing the lumen wall and thus anchoring the device 33 to the lumen wall.

[0107] 在图9-9C所示的另一个示例性实施例中,可通过具有一个或更多个锚固孔57的管状锚固部分56将胆汁收集装置33锚固在胃肠道中,所述锚固孔57旨在面向肠壁部分, 并且能够允许将这些肠壁部分牵拉到孔57内并与其固定。 [0107] In another exemplary embodiment shown in FIG. 9-9C, may be anchored through the tubular portion 56 having one or more anchor holes 57 of the bile collection means 33 is anchored in the gastrointestinal tract, the anchor hole 57 intended for the wall portion, and can allow these wall portions pulled into the bore 57 and secured thereto. 可提供用于从管状锚固部分56 内抽吸管腔壁部分并将其牵拉到锚固孔57内的腔内抽吸装置58、以及用于产生管腔壁部分的永久性(蘑菇头型)溶胀,以防止其从锚固孔57退出的装置和方法。 And the cavity may be provided for the suction means 57 which is pulled into the anchoring holes the anchoring portion 56 from the tubular portion of the suction chamber walls 58, and a permanent (mushroom type) generating lumen wall portion swollen, devices and methods to prevent their exit from the anchor hole 57. 用于产生管腔壁部分的永久性溶胀的此类装置和方法可包括将膨胀剂或硬化剂粘膜下注入到或将塑性珠, 例如聚(甲基丙烯酸甲酯)(PMMA)插入到先前已牵拉穿过锚固孔57的组织部分中。 Such an apparatus and method for generating a permanent swelling of the lumen wall portion may comprise plastic beads or injected into the mucosal swelling agents or hardeners, such as poly (methyl methacrylate) (PMMA) has been previously inserted into the pulled through the tissue portion 57 of the anchor hole.

[0108] 尽管已详细描述了本发明的优选实施例,但申请人的目的并不是将权利要求的范围限于这些特定实施例,而是覆盖落在本发明的范围内的所有修改形式和替代构造。 [0108] Although described in detail preferred embodiments of the present invention, but is not the intention of the applicant to limit the scope of the claims to these specific embodiments, but covers all modifications and alternate constructions falling within the scope of the present invention .

Claims (22)

1. 一种用于调节体液分配的系统(11),所述系统(11)包括调节阀(12)和生理特性感测装置(13),所述调节阀(12)能够被放置在体液的流动通道中,所述生理特性感测装置(13)与所述调节阀(12)信号连通并且能够根据生理特性生成控制信号(14),其中所述调节阀(12)能够响应所述控制信号(14)来改变所述体液的流速,其中所述调节阀(12)包括随载式阀控制器(15)、由所述阀控制器(15)控制的阀致动器(26)、流体通道(27)、和闸门构件(28),所述闸门构件(28)作用在所述流体通道(27)上并且能够通过所述阀致动器(26)在打开位置和关闭位置之间运动,所述闸门构件(28)在所述打开位置释放所述流体通道(27),使得体液能够自由地流过所述流体通道(27),所述闸门构件(28)在所述关闭位置接合所述流体通道(27),从而将所述流体通道(27)关闭。 1. A system (11), said system (11) comprising a regulator valve (12) and physiological sensing means Laid (13), the regulator valve (12) for adjusting the distribution of body fluids can be placed in a bodily fluid flow passage, said sensing physiological Laid means (13) in signal communication with the regulator valve (12) and capable of generating a control signal (14) in accordance with the physiological characteristics, wherein said control valve (12) in response to the control signal (14) to change the flow rate of fluid, wherein the regulator valve (12) comprises a carrier with the control valve (15), controlled by the valve controller (15) valve actuator (26), a fluid channel (27), and the shutter member (28), said shutter member (28) acting on the fluid passage (27) and through said valve actuator (26) between an open position and a closed position said shutter member (28) in the open position releasing the fluid passage (27), such that fluid can freely flow through the fluid passage (27), said shutter member (28) engages in the closed position said fluid passage (27), whereby the fluid passage (27) closed.
2. 根据权利要求1所述的系统(11),其中所述生理特性感测装置(13)包括pH传感器(18),所述pH传感器(18)能够被放置并锚固在患者的胃(2)中,并且能够根据胃内容物的PH值生成pH控制信号(14),并将所述pH控制信号(14)传输到所述调节阀(12)的控制器(15 ;16)〇 2. The system of claim 1 (11), wherein said sensing physiological Laid means (13) comprises a pH sensor (18), the pH sensor (18) can be positioned and anchored in the patient's stomach as claimed in claim (2 ), and can be generated according to the pH value of pH of the stomach contents of a control signal (14), and the pH of the control signal (14) to said regulator control valve (12) (15; 16) square
3. 根据权利要求1或2所述的系统(11),其中所述生理特性感测装置(13)包括温度传感器(19),所述温度传感器(19)能够被放置并锚固在胃(2)中,并且能够根据胃内容物的温度生成温度控制信号,并将所述温度控制信号直接传输到所述调节阀(12)的控制器(15 ;16)〇 3. A system according to claim 1 or 2 (11), wherein said sensing physiological Laid means (13) comprises a temperature sensor (19), said temperature sensor (19) can be placed and anchored in the stomach (as claimed in claim 2 ), and can be generated in accordance with the temperature of the stomach contents temperature control signal, and said temperature control signal is directly transmitted to the adjustment control valve (12) (15; 16) square
4. 根据权利要求1或2所述的系统(I 1),包括无线电信号发射器(20),所述无线电信号发射器(20)能够被设置在所述生理特性感测装置(13)上,以用于所述控制信号(14)的无线传输。 The system (I 1), includes a radio signal transmitter (20) of claim 1 or claim 2, the radio signal transmitter (20) can be provided on the physiological Laid sensing means (13) radio transmission, for the control signal (14).
5. 根据权利要求1所述的系统(11),其中所述生理特性感测装置(13)包括: -用于给所述感测功能以及所述控制信号生成和传输提供能量的可充电随载电池(21), -无线随载电池充电器(22)。 5. The system of claim 1 (11), wherein said sensing physiological Laid means (13) comprises: - means to the sensing function and the control signal generation and transmission provided with a rechargeable energy battery carrier (21), - a wireless carrier with a battery charger (22).
6. 根据权利要求1所述的系统(11),其中所述生理特性感测装置(13)被结合在单个经口插入式胶囊中。 6. The system (11) according to claim 1, wherein said sensing physiological Laid means (13) are combined in a single plug-oral capsules.
7. 根据权利要求6所述的系统(11),包括胶囊捕获装置,所述胶囊捕获装置能够被锚固在食道胃管腔中并且具有胶囊捕获接口,所述胶囊捕获接口能够选择性地捕获、保持和释放所述感测装置(13)胶囊。 7. The system according to claim 6 (11), comprising capturing means capsule, the capsule capture device adapted to be anchored in the esophagus and gastric lumen having a capture interface capsule, the capsule can be selectively capture capture interface, holding and releasing said sensing means (13) of the capsule.
8. 根据权利要求1所述的系统(11),其中所述生理特性感测装置(13)被构造为牙齿植入物并且能够感测患者口腔内的pH值。 8. The system (11) according to claim 1, wherein said sensing physiological Laid means (13) is configured as a dental implant and capable of sensing a pH value in the patient's mouth.
9. 根据权利要求1所述的系统(11),其中所述调节阀(12)的随载控制器(15)包括: -控制信号接收器(30),所述控制信号接收器(30)能够从所述感测装置(13)接收所述控制信号(14); -具有存储器和微处理器的程控信号解析单元(31),所述程控信号解析单元(31)能够根据所接收到的控制信号(14)和加载到所述存储器中的阀控制程序来启动所述阀致动器(26) 〇 9. The system (11) according to claim 1, wherein said regulating valve (12) with a carrier controller (15) comprising: - a control signal receiver (30), said control signal receiver (30) can be from the sensing means (13) receiving said control signal (14); - the received program control signal analysis means (31) having a memory and a microprocessor, a programmed signal analysis means (31) can be according to a control signal (14) and the valve control program loaded into the memory to activate the valve actuator (26) square
10. 根据权利要求1所述的系统(11),包括远程控制单元(16),所述远程控制单元(16)具有: -控制信号接收器(23),所述控制信号接收器(23)能够从所述感测装置(13)接收所述控制信号(14); -具有存储器和微处理器的程控信号解析单元(24),所述程控信号解析单元(24)能够根据所接收到的控制信号(14)和加载到所述存储器中的阀控制程序生成阀控制信号(17); -阀控制信号发射器(25),所述阀控制信号发射器(25)能够将所述阀控制信号(14) 传输到所述调节阀(12)的随载控制器(15)。 10 (11), comprising a remote control unit (16), said remote control unit (16) having a system according to claim 1, wherein: - the control signal receiver (23), said control signal receiver (23) can be from the sensing means (13) receiving said control signal (14); - the received program control signal analysis means (24) having a memory and a microprocessor, a programmed signal analysis means (24) can be according to a control signal (14) and the valve control program loaded into the memory to generate valve control signal (17); - a valve control signal transmitter (25), said valve control signal transmitter (25) capable of placing the control valve signal (14) to said regulator valve (12) with a carrier controller (15).
11. 根据权利要求9或10的所述的系统(11),其中所述信号解析单元(15 ;16)被构造和被程控用于: _将所测量的生理特性值与预定目标值进行比较; _根据一系列随后接收到的控制信号(14)和时间信息来计算所述生理特性的变化。 11. The system (11) according to claim 9 or 10, wherein said signal analysis means (15; 16) is constructed and programmed for: _ The measured physiological characteristic value is compared with a predetermined target value ; change in the physiological characteristic is calculated based on a series of control signals are then received (14) _ and the time information.
12. 根据权利要求9或10所述的系统(11),其中阀控制器(15 ;16)被构造和被程控用于: -响应pH变化控制信号(14)来操作阀致动器(26)以关闭所述调节阀(12),所述pH 变化控制信号指示食物被引入胃(2)内, -响应pH变化控制信号(14)来操作阀致动器(26)以在设定的时延之后打开所述调节阀(12),所述pH变化控制信号指示食物已离开胃(2)并且被传送到消化道的更远侧。 12. The system of claim 9 or 10 (11), as claimed in claim wherein the valve controller (15; 16) is constructed and programmed for: - a control signal in response to changes in pH (14) to operate the valve actuator (26 ) to close the regulator valve (12), said control signal indicates pH change is introduced into the food) (2 stomach, - a control signal in response to changes in pH (14) to operate the valve actuator (26) to set the delay after opening the regulator valve (12), said control signal indicative of pH change has left the stomach of food (2) and transmitted to the digestive tract more distal.
13. 根据权利要求9或10所述的系统(11),其中阀控制器(15 ;16)被构造和被程控用于: -将生理特性控制信号(14)序列与存储的参考值进行比较以计算食物已进入胃(2)的时间点以及食物已从胃(2)穿行到肠内的时间点; -根据食物进入胃(2)的时间点和食物进入肠的时间点以及存储的时间参考值来外推食物或食糜流在胃肠道中的位置; _根据胃肠道中的食物位置以及食物传送和胆胰液分配之间的预置提前时间间隔和延迟时间间隔来启动所述调节阀(12)的阀致动器(26),以调节流动截面。 13. The system of claim 9 or 10 (11), as claimed in claim wherein the valve controller (15; 16) is constructed and programmed for: - the physiological characteristics of the control signal (14) with the stored sequence of reference value to calculate the food has entered the stomach (2) from a time point of the stomach and food (2) to a point walk through the intestines; - a time point into the intestine into the stomach of food according to the time point (2) and storage time of the food and a reference value extrapolated position of the food or chyme flow in the gastrointestinal tract; _ time interval in advance and delay time intervals to activate the regulator valve according to a preset position between the food and the food transport and distribution bile pancreatic juice in the gastrointestinal tract (12) a valve actuator (26), to regulate the flow cross-section.
14. 根据权利要求1所述的系统(11),包括胆汁收集装置(33),所述胆汁收集装置(33) 能够在乏特氏乳头(10)处锚固在小肠中并且能够捕集胆胰液并将其引导到所述调节阀(12)的流体通道(27)中。 14. The system (11) according to claim 1, comprising a bile collection means (33), the bile collection means (33) capable (10) anchored in the small intestine at the papilla of Vater's pancreatic juice and bile capable of trapping and guided to the regulator valve (12) a fluid passage (27).
15. 根据权利要求14所述的系统(11),其中所述胆汁收集装置(33)包括: -管状食物通道槽(34),所述管状食物通道槽(34)具有能够接纳食物流的近侧开口端(35)和能够将食物从槽(34)向远侧释放到肠内的远侧开口端(36); -侧向开放式胆汁收集腔(37),所述侧向开放式胆汁收集腔(37)与所述食物通道槽(34) 隔离并且能够与肠壁的相邻部分一起限定密封的胆汁收集室(38), 所述调节阀(12)与所述胆汁收集腔(37)流体连接。 15. The system (11) according to claim 14, wherein said bile collection means (33) comprising: - a tubular passage Food groove (34), said tubular food passage groove (34) capable of receiving a food stream near side opening end (35) and can be released from the food groove (34) distally to the distal open end of the intestine (36); - laterally open bile collection chamber (37), the open side of bile collection chamber (37) (34) isolated from the food and can define a seal groove passage bile collection chamber (38) together with the adjacent wall portion of the regulating valve (12) and the bile collection chamber (37 ) fluidly connected.
16. 根据权利要求15所述的系统(11),其中所述胆汁收集装置(33)包括能够从初始收缩的径向较小构型膨胀的近侧管腔密封部分(39)和远侧管腔密封部分(40),所述近侧管腔密封部分(39)和远侧管腔密封部分(40)包括能够通过注入膨胀流体或固化膨胀剂而永久性膨胀的可膨胀式球囊节段。 16. The system (11) according to claim 15, wherein said bile collection means (33) comprises a sealing portion proximal lumen collapsible from an initial configuration expanded radially smaller (39) and the distal tube chamber sealing portion (40), (39) a lumen and a distal sealing portion (40) includes an expandable balloon section can be permanently inflated by injecting inflation fluid expansion agent or curing the sealing portion of the proximal lumen .
17. 根据权利要求15所述的系统(11),包括胆汁导管(42),所述胆汁导管(42)具有近侧开口端和远侧开口端以及在两者之间延伸的柔性管,其中所述近侧开口端与所述胆汁收集装置(33)的胆汁收集腔(37)的内部流体连接并且所述远侧开口端能够定位在所述胆汁收集装置(33)较远侧的肠内,所述调节阀(12)布置在所述胆汁导管(42)中以控制从中穿过的胆汁流速。 17. The system according to claim 15 (11), comprising a bile duct (42), the bile duct (42) having an open end and a proximal end and a distal opening of the flexible tubes extending therebetween, wherein the proximal open end of the fluid inside the bile collection means (33) bile collection chamber (37) and is connected to the distal end opening can be positioned in (33) the far side of the intestinal bile collection means the regulating valve (12) is arranged in the bile duct (42) to control the bile flow therethrough.
18. 根据权利要求1所述的系统(11),包括: -用于聚积和保持胆胰液的储存袋(59); -胆汁引流导管(60),所述胆汁引流导管(60)为引入胆道系统(7)中的针并且在能够被固定到所述胆道系统(11)中的近侧开口端和与所述储存袋(59)的近侧入口孔连接的远侧开口端之间延伸; -胆汁分配导管(61),所述胆汁分配导管(61)将所述储存袋(59)的远侧出口孔与所述调节阀(12)连接。 18. The system of claim 1 (11), comprises: - means for accumulation of bile and pancreatic juice holding pocket (59); - biliary drainage catheter (60), the bile drainage catheter (60) is introduced into the biliary tract a needle system (7) and can be fixed to the biliary system (11) in the proximal end and an opening extending between the distal end of the storage bag (59) connected to the proximal opening of the inlet aperture; - bile distribution conduit (61), said dispensing bile duct (61) to said storage bag (59) and a distal outlet aperture of the regulating valve (12) is connected.
19. 根据权利要求18所述的系统(11),其中所述储存袋(59)包括可膨胀式球囊,使得胆汁能够排到所述球囊内并使所述球囊膨胀以供储存。 19. The system (11) according to claim 18, wherein the storage bag (59) comprises an inflatable balloon, such that the bile can be discharged within the balloon and the balloon is inflated for storage.
20. 根据权利要求14所述的系统(11),包括第一套管(43),所述第一套管(43)在漏斗形近侧开口端(44)和远侧开口端(45)之间延伸,所述漏斗形近侧开口端(44)能够锚固在胃(2)内,所述远侧开口端(45)连接到所述胆汁收集装置(33)的近侧孔(35),所述第一套管(43)能够将所述胆汁收集装置(33)锚固在胃肠道中并且能够收集容纳在胃(2)中的食物并将其引导到所述食物通道槽(34)内而不与所述肠壁接触。 20. The system according to claim 14 (11), comprising a first sleeve (43), the first sleeve (43) at the end of the funnel-shaped proximal opening (44) and a distal open end (45) extending between the proximal opening of the funnel-shaped end (44) can be anchored within the stomach (2), said open distal end (45) connected to the bile collection means (33) of the proximal bore (35) , the first sleeve (43) capable of collecting the bile means (33) anchored in the gastrointestinal tract and can be collected in the stomach received food (2) and guided into the food passage groove (34) without contacting with the inner wall.
21. 根据权利要求14或20所述的系统(11),包括第二套管(64),所述第二套管(64) 从所述胆汁收集装置(33)的远侧开口端(36)向远侧延伸,以将部分消化的食物与所述肠壁隔离。 21. The system of claim 14 or claim 20 (11), comprising a second bushing (64), the second sleeve (64) from the open end of the bile collection means (33) of the distal (36 ) extends distally to the partially digested food and isolating the intestinal wall.
22. 根据权利要求14所述的系统(11),包括用于将所述胆汁收集装置(33)锚固在胃肠道中的锚固装置,所述锚固装置选自: _胃线圈(46),所述胃线圈(46)能够从将其经口或经鼻传送到胃(2)内的延展构型弹性变形为能够与胃(2)适形连接的旋拧弓形构型; -锚固线(47),所述锚固线(47)具有T形箍连接件以用于固定到胃壁中的折襞(48); -粘膜下带(49)和环状锚固凹槽(50),所述粘膜下带(49)能够插入肠壁中以形成锚固环,所述环状锚固凹槽(50)形成于所述胆汁收集装置(33)中并且能够接合所述锚固环; -T形箍锚固体(53),所述T形箍锚固体(53)能够从肠内击送到肠壁中以形成固定点, 所述T形箍锚固体(53)能够与所述胆汁收集装置(33)的近端连接; -环状锚固部分(54),所述环状锚固部分(54)具有多个锚固倒钩(55),所述倒钩(55) 能够从静止位置运动到 22. The system of claim 14 (11), comprising means for collecting the bile (33) anchored in the anchoring device of the gastrointestinal tract, the anchoring apparatus as claimed in claim selected from: _ gastric coil (46), the said gastric coil (46) can be from transmits it to the stomach through the mouth or nasal extended configuration the elastic (2) modified to be capable of the stomach (2) is adapted screwed arcuate configuration-connected; - an anchor line (47 ), the anchor line (47) having a T-shaped connecting member for fixing the ferrule to the plication in the stomach wall (48); - submucosal belt (49) and an annular anchoring groove (50), the submucosal belt (49) can be inserted into the intestinal wall to form an anchoring ring, the annular anchoring recess (50) formed in the bile collection means (33) and to engage said anchoring ring; -T band-shaped anchor ( 53), said T-shaped anchor band (53) can be fed from the intestinal wall to strike a fixed point is formed, the T-shaped anchor band (53) capable of bile near the collection means (33) terminal; - an annular anchoring part (54), the annular anchoring portion (54) having a plurality of anchoring barbs (55), said barb (55) from a rest position to 作位置,在所述静止位置所述倒钩(55)容纳在所述锚固部分(54)的范围内,在所述工作位置所述倒钩(55)径向向外凸出; -管状锚固部分(56)和用于产生管腔壁部分的永久性蘑菇头形肿胀、从而防止其从锚固孔(57)退出的装置,所述管状锚固部分(56)具有一个或更多个所述锚固孔(57),一个或更多个所述锚固孔(57)旨在面向肠壁部分并且能够允许将这些肠壁部分牵拉到所述孔(57)内并与其固定。 Operating position, in the rest position of the barbs (55) housed within said anchoring portion (54) in the working position of the barbs (55) projecting radially outwardly; - tubular anchoring portion (56) and a mushroom-shaped head for generating a permanent swelling of the lumen wall portion, thereby preventing the anchoring means from its exit orifice (57), the tubular anchoring portion (56) having one or more of the anchor hole (57), one or more of the anchoring holes (57) intended for the wall portion and fixed thereto and can allow these wall portions pulled into the bore (57) therein.
CN201080068040.XA 2010-07-16 2010-07-16 Adjusting the fluid distribution system CN103002839B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2010/060273 WO2012007046A1 (en) 2010-07-16 2010-07-16 A system regulating the dispensing of a body fluid

Publications (2)

Publication Number Publication Date
CN103002839A CN103002839A (en) 2013-03-27
CN103002839B true CN103002839B (en) 2015-11-25

Family

ID=43587545

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080068040.XA CN103002839B (en) 2010-07-16 2010-07-16 Adjusting the fluid distribution system

Country Status (2)

Country Link
CN (1) CN103002839B (en)
WO (1) WO2012007046A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104826217B (en) * 2015-05-11 2018-01-16 大连大学 Bile pancreatic juice drainage tube

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2074971A1 (en) * 2007-12-27 2009-07-01 Ethicon Endo-Surgery, Inc. Fluid logic for regulating restriction devices
EP2095796A1 (en) * 2008-02-26 2009-09-02 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction device
CN101536938A (en) * 2008-01-29 2009-09-23 伊西康内外科公司 Sensor trigger

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314489B2 (en) 2003-08-20 2008-01-01 Ethicon Endo-Surgery, Inc. Method and apparatus to facilitate nutritional malabsorption
WO2005120363A1 (en) * 2004-06-03 2005-12-22 Mayo Foundation For Medical Education And Research Obesity treatment and device
WO2007103773A2 (en) * 2006-03-02 2007-09-13 Laufer Michael D Gastrointestinal implant and methods for use
US8597278B2 (en) 2006-06-23 2013-12-03 MEDIMETRICS Personalized Drug Delivery B.V. Medicament delivery system and process
US9550050B2 (en) 2006-09-25 2017-01-24 MEDIMETRICS Personalized Drug Delivery B.V. Medicament delivery apparatus
EP2101643B1 (en) 2006-10-31 2013-04-24 Medimetrics Personalized Drug Delivery B.V. Design of swallowable multi-nozzle, dosing device for releasing medicines in the gastrointestinal tract
WO2008062333A2 (en) 2006-11-21 2008-05-29 Koninklijke Philips Electronics, N.V. Ingestible electronic capsule and in vivo drug delivery or diagnostic system
WO2008062335A1 (en) 2006-11-21 2008-05-29 Koninklijke Philips Electronics, N.V. Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2074971A1 (en) * 2007-12-27 2009-07-01 Ethicon Endo-Surgery, Inc. Fluid logic for regulating restriction devices
CN101536938A (en) * 2008-01-29 2009-09-23 伊西康内外科公司 Sensor trigger
EP2095796A1 (en) * 2008-02-26 2009-09-02 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction device

Also Published As

Publication number Publication date
WO2012007046A1 (en) 2012-01-19
CN103002839A (en) 2013-03-27

Similar Documents

Publication Publication Date Title
AU2006273679B2 (en) Extending intrabody capsule
US8172857B2 (en) Endoscopic tissue apposition device and method of use
US4246893A (en) Inflatable gastric device for treating obesity
US7935073B2 (en) Methods of treatment using a bariatric sleeve
US9561033B2 (en) Apparatus for treating obesity
EP2061397B1 (en) Intestinal sleeves and associated deployment systems
US7981162B2 (en) Satiation devices and methods
US6454785B2 (en) Percutaneous intragastric balloon catheter for the treatment of obesity
US8795301B2 (en) Device for intermittently obstructing a gastric opening and method of use
AU2005231323B2 (en) Systems and methods for treating obesity
ES2483791T3 (en) Positioning instruments to implement a bag of satiety
CA2638988C (en) Intragastric space filler
US6432040B1 (en) Implantable esophageal sphincter apparatus for gastroesophageal reflux disease and method
US8182441B2 (en) Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US8187297B2 (en) Devices and methods for treatment of obesity
CA2638163C (en) Inflatable intragastric space filler devices for treating obesity
US7678068B2 (en) Atraumatic delivery devices
US9358144B2 (en) Gastrointestinal implants
EP1968506B1 (en) Coiled intragastric member for treating obesity
US20060069400A1 (en) Method and apparatus for anchoring implants
US9278019B2 (en) Anchors and methods for intestinal bypass sleeves
US20130184635A1 (en) Obesity treatment and device
US20040044353A1 (en) Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US20050022827A1 (en) Method and device for gastrointestinal bypass
AU2005274132B2 (en) Devices and methods for pyloric anchoring

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
C14 Grant of patent or utility model