CN102986684A - Production method of suspension concentrate (SC) containing difenoconazole - Google Patents

Abstract

The invention belongs to the field of pesticide bactericides and in particular relates to a production method of a suspension concentrate (SC) containing difenoconazole. The SC comprises difenoconazole, bismerthiazol, surfactants, water and other functional aids, wherein the weight percent of difenoconazole is 1-20%; and the weight ratio of difenoconazole to bismerthiazol is (5:1)-(1:5). The composition is mainly used for controlling watermelon gummy stem blight, pepper anthracnose, strawberry powdery mildew, grape anthracnose, heiyabing, citrus scab, rice bacterial leaf blight, cucumber target leaf spot and the like and has the characteristics of obvious synergy, bactericidal broad spectrum, long duration, safety for crops and the like.

Description

The production method that contains the aqueous suspension agent of Difenoconazole

Technical field

The invention belongs to the disinfectant use in agriculture field, particularly a kind of production method that contains the aqueous suspension agent of Difenoconazole.

Background technology

Difenoconazole is a kind of bactericide of broad-spectrum high efficacy; the main biosynthesis that suppresses germ cell ergosterol; thereby destroy membrane structure and function; be mainly used in fruit tree, vegetables, wheat, potato, beans, the crop such as melon, the multiple fungal diseases such as vegetables and melon and fruit are had good protection and therapeutic action.But mobility is little in soil, slow degradation.Can prevent and treat pear scab, alternaria leaf spot of apple, tomato drought epidemic disease, the climing rot of watermelon, pepper anthracnose, powdery mildew of strawberry, bitter rot or anthracnose of grape, black Ya disease, citrus scab etc.　

Yekuzuo (bismerthlazol) is the interior suction series bactericidal agent of the autonomous initiative of China, be the new type bactericide agricultural chemicals that the world is pioneering, efficient, low toxicity, low-residual, the lasting period is long, interior absorption is strong, have good control efficiency to preventing and treating bacterial blight of rice, bacterial leaf spot, citrus ulcer etc.

Often there is defective in various degree in the bactericide kind that contains the single-activity component in the disinfectant use in agriculture control, narrow such as bactericidal range, control efficiency is poor, and dispenser dosage Da Yi develops immunity to drugs, and application times is added heavily environmental pollution etc.For the upper germ that produces resistance of control agricultural, a kind of way is to release new and the new component of existing kind without cross resistance.But the development cost of new active ingredient is high, and the construction cycle is long, and does not all catch up with the speed that germ produces resistance forever.Other way is rotated etc. such as crop allocation adjustment, different agricultural chemicals, in the process of practical operation, is difficult to really play obvious effect.

The different cultivars composition carries out composite, is to prevent and treat the modal method of resistance germ.Heterogeneity is carried out composite, can improve control efficiency, enlarges bactericidal range, reduces the consumption of active ingredient, saves drug cost, reduces environmental pollution, is the important means of integrated control field disease.

Through retrieval, at present do not find Difenoconazole with Yekuzuo is composite and the document of application.

Summary of the invention

The present invention aims to provide the production method of the aqueous suspension agent that contains Difenoconazole of a kind of good drug efficacy, lasting period length, and its active ingredient is Difenoconazole and Yekuzuo.

Technical scheme of the present invention is: a kind of production method that contains the aqueous suspension agent of Difenoconazole: active ingredient Difenoconazole, Yekuzuo, surfactant and other functional aid are placed batching kettle successively, adding water mixes, through high speed shear, the wet method sand milling, last homogeneous filtration namely gets product, and wherein the weight content of Difenoconazole is 1%～20%.

Optimize, the weight ratio of Difenoconazole and Yekuzuo is 5:1～1:5.

The described purposes that contains the aqueous suspension agent of Difenoconazole is: its application aspect the climing rot of control watermelon, pepper anthracnose, powdery mildew of strawberry, bitter rot or anthracnose of grape, black Ya disease, citrus scab, bacterial blight of rice, Leaf Spot Caused by Corynespora cassiicola on Cucumber, pear scab, alternaria leaf spot of apple, tomato drought epidemic disease, bacterial blight of rice or bacterial stripe, citrus ulcer.

Above-mentioned active ingredient Difenoconazole and Yekuzuo all are bactericide well known in the art, can buy by various commercial channel.

Described surfactant can be one or more in emulsifier, dispersant, wetting agent or the bleeding agent, can be nonionic or anionic, also can be two types of compound uses.

Described emulsifier is selected from neopelex, the newborn 500#(calcium dodecyl benzene sulfonate of farming), the newborn 600#(styrylphenol polyoxyethylene ether of farming) OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (styryl phenol polyethenoxy ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, the newborn 400#(benzyl dimethyl phenol polyoxy ethyl ether of farming), Nongru-700 #(alkylphenol-formaldehyde resin polyoxy ethyl ether), peaceful newborn 36#(phenethyl fluosite polyoxy ethyl ether), the newborn 1600#(phenethyl phenol polyoxy ethyl polypropylene-base ether of farming), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), BY series (castor oil polyoxyethylene ether), the newborn 33#(alkylaryl polyoxyethylene poly-oxygen propylene aether of farming), sapn series (sorbitol anhydride monostearate), the mixture of one or more compositions in tween series (anhydrous sorbitol resin acid ester APEO) or the AEO series (fatty alcohol-polyoxyethylene ether).

Described dispersant is selected from the mixture of one or more compositions in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene calcium sulfonate, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, aliphatic acid polyethenoxy ether or the fatty acid glyceride APEO.

Described wetting agent is selected from the mixture of one or more compositions in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement or the soapberry powder.

Described bleeding agent is selected from the mixture of one or more compositions in penetrating agent JFC (fatty alcohol-polyoxyethylene ether), penetrant t (Maleic Acid Diisooctyl sulfonate), azone, the organosilicon.

Described other functional aids are selected from one or more in antifreezing agent, thickener, stabilizing agent, disintegrant, the defoamer.

Described thickener is selected from the mixture of one or more compositions in gelatin, sodium carboxymethylcellulose, hydroxyethylcellulose, Sodium Polyacrylate, modified starch, xanthans, bentonite, silica and the Magnesiumaluminumsilicate.

Described antifreezing agent is selected from the mixture of one or more compositions in ethylene glycol, propane diols, glycerine or the urea.

Described defoamer is selected from the mixture of one or more compositions in silicone oil, silicone compound, C10～C20 saturated fat acid compounds or C8～C10 aliphatic alcohols compound.

Described disintegrant is selected from the mixture of one or more compositions in bentonite, urea, ammonium sulfate, aluminium chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or the sodium bicarbonate.

Described stabilizing agent is selected from epoxidized soybean oil, epoxychloropropane, BHT, ethyl acetate, the mixture of one or more compositions of triphenyl phosphate.

Material described above all is to well known to a person skilled in the art material, can buy by market.

Beneficial effect of the present invention is: 1, the aqueous suspension agent synergistic effect of Difenoconazole and the compound formation of Yekuzuo is obvious, is not the simple superposition of each composition activity, but significant synergistic effect is arranged; 2, the field consumption of active ingredient descends, and has reduced production and use cost, reduces residue of pesticide and environmental pollution; 3, aqueous suspension agent is comprised of the active ingredient of different mechanism of action, is conducive to overcome and delays the drug-fast generation of germ, and is significant to crop safety and integrated control crop germ; 4, Difenoconazole and Yekuzuo compound after, enlarged fungicidal spectrum, the medicament characteristic has obtained mutual supplement with each other's advantages, can prevent and treat the various crop disease, makes things convenient for peasant's medication.

Embodiment

Specify the present invention below in conjunction with embodiment.Percentage all is weight percentage among the embodiment, and the treatment dosage of field efficacy is effective ingredient consumption.

Embodiment 1:(40% Difenoconazole Yekuzuo aqueous suspension agent)

The production method of the aqueous suspension agent that contains Difenoconazole of the present embodiment: active ingredient Difenoconazole and Yekuzuo, surfactant and other functional aid are placed batching kettle successively, adding water mixes, through high speed shear, the wet method sand milling, last homogeneous filtration namely gets product.Capital equipment is batching kettle, colloid mill, sand mill.

Component and the weight content of the aqueous suspension agent that contains Difenoconazole of the present embodiment are as follows: Difenoconazole, 10%; Yekuzuo, 30%; The newborn OP-10 of emulsifier farming, 2%; Dispersant polycarboxylate, 8%; Thickener is selected xanthans and aluminium-magnesium silicate, and consumption is respectively 0.1% and 2%; Antifreeze glycol, 5%; The defoamer silicone compound, 0.5%; Water, surplus.

Embodiment 2:(50% Difenoconazole Yekuzuo wetting powder)

The difference of the present embodiment and embodiment 1 is: component and the weight content of the aqueous suspension agent that contains Difenoconazole of the present embodiment are as follows: Difenoconazole, 15%; Yekuzuo, 35%; The emulsifier ethylene oxide-propylene oxide block copolymer, 3%; Dispersant polycarboxylate, 8%; Thickener is selected xanthans and aluminium-magnesium silicate, and consumption is respectively 0.1% and 2%; Antifreeze glycol, 5%; The defoamer silicone compound, 0.5%; Water, surplus.

Embodiment 3:(65% Difenoconazole Yekuzuo water dispersible granules)

The difference of the present embodiment and embodiment 1 is: component and the weight content of the aqueous suspension agent that contains Difenoconazole of the present embodiment are as follows: Difenoconazole, 20%; Yekuzuo, 45%; The newborn OP-10 of emulsifier farming, 2%; The dispersant lignosulfonates, 9%; Thickener is selected xanthans and aluminium-magnesium silicate, and consumption is respectively 0.1% and 2%; Antifreeze glycol, 5%; The defoamer silicone compound, 0.5%; Water, surplus.

Embodiment 4:30% Difenoconazole Yekuzuo missible oil

The difference of the present embodiment and embodiment 1 is: component and the weight content of the aqueous suspension agent that contains Difenoconazole of the present embodiment are as follows: Difenoconazole, 10%; Yekuzuo, 20%; Emulsifier 500#, 4.5%; The newborn 600# of farming, 5.5%; Dispersant polycarboxylate, 8%; Thickener is selected xanthans and aluminium-magnesium silicate, and consumption is respectively 0.1% and 2%; Antifreeze glycol, 5%; The defoamer silicone compound, 0.5%; Water, surplus.

But the below uses embodiment medicament 40% Difenoconazole Yekuzuo aqueous suspension agent, with Comparative Examples medicament 37% difenoconazole water dispersible granule and 20% Yekuzuo wet-milling bacterial leaf streak of rice is carried out field control effectiveness test, so that beneficial effect of the present invention to be described better, result of the test is as shown in table 1 below.

Establish embodiment medicament, Comparative Examples medicament and do not use totally 6 processing of any medicament in this field test, each is processed and repeats 4 times, process the residential quarter for totally 24, every processing residential quarter takes by weighing medicament according to table 1 listed medicament and the amount of taking thereof, then be watered, select the basically identical field of growing way and morbidity to implement the spray medicine in rice tillering latter stage to the booting initial stage, spray value is 45,000 g/acres.For the second time medicine is executed at the interval after for the first time dispenser after 5 days, and dispenser is twice altogether.Every processing residential quarter is got 3 points at random, gets 10 root and stem of certain plants paddy rice at every, at blade and the stem scab number, lesion area of investigation in 7 days, 15 days after the medication second time on the paddy rice, calculates control efficiency with disease index.

The scab grade scale is with reference to State Standard of the People's Republic of China " pesticide field efficacy medicine test criterion ".The blade occurring degree is divided into 5 grades, and 0 grade: blade is without scab; 1 grade: lesion area accounts for whole blade area below 1/4; 2 grades: the morbidity of 1/4 to 2/4 lesion area; 3 grades: the morbidity of 2/4 to 3/4 lesion area; 4 grades: 3/4 above leaf area morbidity.Disease refers to calculate as follows with control efficiency:

　　

Table 1 different disposal is to the control efficiency of bacterial leaf streak of rice

Can find out from table 1 result of the test, for the second time dispenser is after 7 days, 15 days, embodiment medicament 40% Difenoconazole Yekuzuo aqueous suspension agent to the control efficiency of bacterial leaf streak of rice all more than 83%, apparently higher than contrast agents.Embodiment medicament using dosage is low, and only for 1/2 of contrast agents just can reach good control efficiency, and the medicament efficiency time is long, and dispenser still reaches fine control efficiency after 15 days.Experimental session is observed, and without poisoning, safety is good to paddy rice for the embodiment medicament.The above results shows that the aqueous suspension agent that contains Difenoconazole of the present invention is better than Comparative Examples.

Claims (2)

1. production method that contains the aqueous suspension agent of Difenoconazole, it is characterized in that: active ingredient Difenoconazole, Yekuzuo, surfactant and other functional aid are placed batching kettle successively, adding water mixes, through high speed shear, the wet method sand milling, last homogeneous filtration namely gets product, and wherein the weight content of Difenoconazole is 1%～20%.

2. the production method that contains the aqueous suspension agent of Difenoconazole according to claim 1, it is characterized in that: the weight ratio of Difenoconazole and Yekuzuo is 5:1～1:5.