CN102974411A - Microfluidic device and method for preparing monodispersed bubble covered with liquid film by utilizing same - Google Patents
Microfluidic device and method for preparing monodispersed bubble covered with liquid film by utilizing same Download PDFInfo
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Abstract
The invention discloses a microfluidic device and a method for preparing monodispersed bubbles covered with a liquid film by utilizing the same, and belongs to the technical field of chemical industry. The method adopts the double coaxial loop microfluidic device as a dispersing device, the microfluidic device is formed by orderly sheathing an external continuous phase channel, a middle liquid film phase pipeline and an internal gaseous phase pipeline, and the inlet of each pipeline is independently communicated with the outside. Uniform bubbles covered with the liquid films are prepared in the continuous phase by utilizing a first grade laminar flow and second grade shearing dispersion mode. The technique can be used for accurately controlling the relative deviation of the diameter of the bubbles to make the relative deviation of the diameter of the bubbles less than 3%, accurately controlling the diameter of the bubbles within 70-2000mu m, and accurately regulating and controlling the thickness of the liquid film covering the surfaces of the bubbles within 0.2-50 mu m.
Description
Technical field
The invention belongs to chemical technology field, be specifically related to a kind of microfluidic device and prepare the method that coats the liquid film monodisperse bubble.
Technical background
Single microbubble that disperses of diameter homogeneous has a good application prospect at numerous areas such as chemistry, chemical industry, material, biology, pharmacy, the bubble that the surface coats liquid film is a kind of bubble of special construction, can be used for the manufacture process of the new high-tech products such as senior expanded material, photoelectric display equipment, living things catalysis material, medicament capsule carrier.The preparation difficult point that coats soap bubble is to control the uniformity (monodispersity) of bubble, and the Modulatory character of bubble diameter and thickness of liquid film, the preparation that the method for bubbling is difficult to adapt to micro-meter scale bubble and single dispersion diameter in the tradition tower-type equipment requires that (diameter is less than 1mm, the diameter relative deviation is less than 5%), the microfluidic device that develops at chemical field in recent years is to realize a single new technical means that disperses the microbubble preparation.
Result of study shows: utilize T microchannel, hydraulics to focus on the little dispersing apparatus of microfluidic device such as microchannel, coaxial endless tube microchannel and can accurately control the dispersion size of drop or bubble in several microns to several millimeters scopes, and the diameter relative deviation of drop or bubble is less than 5%, the dispersion size of little drop or microbubble is relevant with operating conditions such as flow, viscosity, interfacial tensions, can adjust by changing device structure and operating condition size and the distribution of drop or bubble.The multiple little dispersed structure of combination can be realized the preparation of the multiple emulsions such as W/O/W, oil-in-water bag gas in same microfluidic device, and these multiple emulsion technologies of preparing are technical foundation that preparation coats the microbubble of liquid film.
Summary of the invention
The object of the present invention is to provide a kind of microfluidic device and prepare the method that coats the liquid film monodisperse bubble.
A kind of two coaxial endless tube microfluidic device, this equipment is by outer continuous phase passage, intermediate layer liquid film phase pipeline and internal layer gas phase pipeline successively nested forming, and wherein the import of each pipeline independently is in communication with the outside; This equipment continuous phase channel water aerodynamic diameter is at 200 μ m ~ 1000 μ m, gas phase endless tube road import hydraulic diameter is 80 μ m ~ 300 μ m, the import front end of liquid film phase pipeline is conical, the cone point hydraulic diameter is 10 μ m ~ 100 μ m, and the terminal hydraulic diameter of its import is 120 μ m ~ 800 μ m.
A kind ofly utilize the above-mentioned equipment of stating to prepare the method that coats the liquid film monodisperse bubble, in equipment gas phase pipeline, pass into gas phase, pass into the liquid film phase in the liquid film phase pipeline, pass into continuous phase in the continuous phase passage, it is that the stratified flow of ring-type is flowed that the gas phase between gas phase pipeline and the liquid film phase pipeline and liquid film are the cross section mutually; Liquid film phase pipe end, gas-liquid two-phase are subjected to the continuous phase shearing and disperse, and outlet obtains to disperse to become the bubble of covering liquid film; Wherein bubble diameter is recently realized by the flow of adjusting gas phase and continuous phase or is realized that by the hydraulic diameter of adjusting outer continuous phase passage the flow-rate ratio of gas phase and continuous phase is 1:(0.5 ~ 200); Thickness of liquid film realizes recently that by the flow of adjusting liquid film phase and gas phase liquid film is 0.0001 ~ 0.01 with the gas phase flow rate ratio.
Wherein gas phase, liquid film phase and continuous phase is not for dissolving each other or the solution-air of partial miscibility-liquid three-phase fluid body, and interfacial tension satisfies physical relation γ between three-phase
Gas connectsγ
Air film+ γ
Film connects, γ wherein
Gas connectsBe the interfacial tension between gas phase and the continuous phase, γ
Air filmBe the interfacial tension between gas phase and the liquid film phase, γ
Film connectsBe the interfacial tension between liquid film phase and the continuous phase.
The beneficial effect of the inventive method is: utilize microfluidic device of the present invention, dispersing mode by this " one-level laminar flow, secondary shear " can accurately be controlled bubble diameter, make its relative deviation less than 3%, in 5 μ m ~ 2000 mu m ranges, can accurately control bubble diameter, bubble surface covering liquid film thickness also can be between 0.2 μ m ~ 50 μ m accuracy controlling.
Description of drawings
Fig. 1 is two coaxial endless tube microfluidic device structural representations.
Fig. 2 is for coating the monodisperse bubble of liquid film; Wherein scale is 1mm.
The specific embodiment
Below by with instantiation the present invention being further specified by reference to the accompanying drawings.
Embodiment 1
The two coaxial endless tube microfluidic device of use shown in accompanying drawing 1,2, the outer continuous phase channel water of equipment aerodynamic diameter is 1000 μ m, liquid film phase conduit entrance terminal hydraulic diameter in intermediate layer is 800 μ m, and the cone point diameter is 100 μ m, and internal layer gas phase endless tube road hydraulic diameter is 300 μ m.The selection air is gas phase, and silicone oil is the liquid film phase, and sodium dodecyl sulfate aqueous solution is continuous phase, and the flow-rate ratio of three-phase is the liquid film phase: gas phase: continuous phase=0.004:1:0.5.The bubble mean diameter that outlet obtains is 1940 μ m, diameter relative deviation 1.9%, thickness of liquid film 2.2 μ m.
Embodiment 2
The two coaxial endless tube microfluidic device of use shown in accompanying drawing 1,2, the outer continuous phase channel water of equipment aerodynamic diameter is 700 μ m, liquid film phase conduit entrance terminal hydraulic diameter in intermediate layer is 600 μ m, and the cone point diameter is 50 μ m, and internal layer gas phase endless tube road hydraulic diameter is 300 μ m.Selecting the gaseous mixture of carbon dioxide nitrogen is gas phase, and silicone oil is the liquid film phase, dodecyl sodium sulfate and PVA(polyvinyl alcohol) the aqueous solution be continuous phase, the flow-rate ratio of three-phase is the liquid film phase: gas phase: continuous phase=0.01:1:120.The bubble mean diameter that outlet obtains is 442 μ m, diameter relative deviation 1.7%, thickness of liquid film 49.6 μ m.
Embodiment 3
Use is similar to the two coaxial endless tube microfluidic device shown in the accompanying drawing 1,2, the outer continuous phase channel water of equipment aerodynamic diameter is 200 μ m, liquid film phase conduit entrance terminal hydraulic diameter in intermediate layer is 120 μ m, and the cone point diameter is 10 μ m, and internal layer gas phase endless tube road hydraulic diameter is 80 μ m.Selection nitrogen is gas phase, the mixed solution of silicone oil and normal octane be liquid film mutually, dodecyl sodium sulfate and PEG(polyethylene glycol) the aqueous solution be continuous phase, the flow-rate ratio of three-phase is the liquid film phase: gas phase: continuous phase=0.0001:2:300.The bubble mean diameter that outlet obtains is 51 μ m, diameter relative deviation 2.2%, thickness of liquid film 0.5 μ m.
Claims (3)
1. a two coaxial endless tube microfluidic device is characterized in that this equipment is by outer continuous phase passage, intermediate layer liquid film phase pipeline and internal layer gas phase pipeline successively nested forming, and wherein the import of each pipeline independently is in communication with the outside; This equipment continuous phase channel water aerodynamic diameter is at 200 μ m ~ 1000 μ m, gas phase endless tube road import hydraulic diameter is 80 μ m ~ 300 μ m, the import front end of liquid film phase pipeline is conical, the cone point hydraulic diameter is 10 μ m ~ 100 μ m, and the terminal hydraulic diameter of its import is 120 μ m ~ 800 μ m.
2. one kind is utilized the described equipment of claim 1 to prepare the method that coats the liquid film monodisperse bubble, it is characterized in that, in equipment gas phase pipeline, pass into gas phase, pass into the liquid film phase in the liquid film phase pipeline, pass into continuous phase in the continuous phase passage, it is that the stratified flow of ring-type is flowed that the gas phase between gas phase pipeline and the liquid film phase pipeline and liquid film are the cross section mutually; Liquid film phase pipe end, gas-liquid two-phase are subjected to the continuous phase shearing and disperse, and outlet obtains to disperse to become the bubble of covering liquid film; Wherein bubble diameter is recently realized by the flow of adjusting gas phase and continuous phase or is realized that by the hydraulic diameter of adjusting outer continuous phase passage the flow-rate ratio of gas phase and continuous phase is 1:(0.5 ~ 200); Thickness of liquid film realizes recently that by the flow of adjusting liquid film phase and gas phase liquid film is 0.0001 ~ 0.01 with the gas phase flow rate ratio.
3. the method that coats the liquid film monodisperse bubble for preparing according to claim 2 is characterized in that, wherein gas phase, liquid film phase and continuous phase is not for dissolving each other or the solution-air of partial miscibility-liquid three-phase fluid body, and interfacial tension satisfies physical relation γ between three-phase
Gas connectsγ
Air film+ γ
Film connects
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069757A (en) * | 2014-07-07 | 2014-10-01 | 东南大学 | Dual-microemulsion rapid preparation device |
| CN104741023A (en) * | 2015-03-02 | 2015-07-01 | 清华大学 | Micro-structural device for preparing mono-dispersed liquid drops and bubbles and use method of micro-structural device |
| CN104941702A (en) * | 2015-05-25 | 2015-09-30 | 重庆大学 | Ultra-small droplet generation method in micro channel |
| CN105772129A (en) * | 2016-03-04 | 2016-07-20 | 上海理工大学 | Integrated microfluidic device and method for preparing microdroplets |
| CN106110340A (en) * | 2016-07-12 | 2016-11-16 | 陈传品 | A kind of method and device preparing target drug-carrying microbubble |
| CN108905644A (en) * | 2018-05-02 | 2018-11-30 | 华南师范大学 | A kind of method that hydrogen bubble template prepares porous polymer film |
| CN110203953A (en) * | 2019-07-15 | 2019-09-06 | 清华大学 | A kind of gama-alumina microsphere and preparation method thereof |
| CN110787846A (en) * | 2019-11-05 | 2020-02-14 | 华中科技大学 | One-step double-layer micro-droplet generation device and method |
| CN111417457A (en) * | 2018-03-20 | 2020-07-14 | 株式会社岛津制作所 | Small bubble supply device and small bubble analysis system |
| CN111902207A (en) * | 2018-02-15 | 2020-11-06 | 剑桥企业有限公司 | Continuous reactor device with constant shear |
| CN112871102A (en) * | 2021-04-16 | 2021-06-01 | 中国矿业大学 | Control method for preparing phase-change capsules on large scale based on microfluidics |
| CN114534590A (en) * | 2022-02-26 | 2022-05-27 | 四川大学 | Rotary sleeve microfluidic device and method for controllably preparing monodisperse double emulsion |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069757A (en) * | 2014-07-07 | 2014-10-01 | 东南大学 | Dual-microemulsion rapid preparation device |
| CN104741023A (en) * | 2015-03-02 | 2015-07-01 | 清华大学 | Micro-structural device for preparing mono-dispersed liquid drops and bubbles and use method of micro-structural device |
| CN104941702A (en) * | 2015-05-25 | 2015-09-30 | 重庆大学 | Ultra-small droplet generation method in micro channel |
| CN104941702B (en) * | 2015-05-25 | 2017-01-04 | 重庆大学 | A kind of method producing extra small drop in microchannel |
| CN105772129A (en) * | 2016-03-04 | 2016-07-20 | 上海理工大学 | Integrated microfluidic device and method for preparing microdroplets |
| CN106110340B (en) * | 2016-07-12 | 2019-09-03 | 陈传品 | A kind of method and device preparing target drug-carrying microbubble |
| CN106110340A (en) * | 2016-07-12 | 2016-11-16 | 陈传品 | A kind of method and device preparing target drug-carrying microbubble |
| US11724241B2 (en) | 2018-02-15 | 2023-08-15 | Cambridge Enterprise Limited | Constant shear continuous reactor device |
| CN111902207A (en) * | 2018-02-15 | 2020-11-06 | 剑桥企业有限公司 | Continuous reactor device with constant shear |
| CN111902207B (en) * | 2018-02-15 | 2022-08-05 | 剑桥企业有限公司 | Continuous reactor device with constant shear |
| CN111417457A (en) * | 2018-03-20 | 2020-07-14 | 株式会社岛津制作所 | Small bubble supply device and small bubble analysis system |
| CN108905644A (en) * | 2018-05-02 | 2018-11-30 | 华南师范大学 | A kind of method that hydrogen bubble template prepares porous polymer film |
| CN108905644B (en) * | 2018-05-02 | 2021-05-25 | 华南师范大学 | Method for preparing porous polymer film by bubble template method |
| CN110203953A (en) * | 2019-07-15 | 2019-09-06 | 清华大学 | A kind of gama-alumina microsphere and preparation method thereof |
| CN110787846B (en) * | 2019-11-05 | 2021-04-16 | 华中科技大学 | One-step double-layer micro-droplet generation device and method |
| CN110787846A (en) * | 2019-11-05 | 2020-02-14 | 华中科技大学 | One-step double-layer micro-droplet generation device and method |
| CN112871102A (en) * | 2021-04-16 | 2021-06-01 | 中国矿业大学 | Control method for preparing phase-change capsules on large scale based on microfluidics |
| CN114534590A (en) * | 2022-02-26 | 2022-05-27 | 四川大学 | Rotary sleeve microfluidic device and method for controllably preparing monodisperse double emulsion |
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