CN102967872A - Body cavity inner dose detector integrated in brachytherapy system - Google Patents
Body cavity inner dose detector integrated in brachytherapy system Download PDFInfo
- Publication number
- CN102967872A CN102967872A CN2011102658801A CN201110265880A CN102967872A CN 102967872 A CN102967872 A CN 102967872A CN 2011102658801 A CN2011102658801 A CN 2011102658801A CN 201110265880 A CN201110265880 A CN 201110265880A CN 102967872 A CN102967872 A CN 102967872A
- Authority
- CN
- China
- Prior art keywords
- dose
- body cavity
- radioactive source
- sensor
- brachytherapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
The invention provides a body cavity inner dose sensor capable of being inserted in a catheter (attached image B) of an applicator (attached image A). In a high dose rate brachytherapy process, the dose sensor is implanted in a body cavity of a patient through the applicator so as to achieve real-time continuous detection of body cavity internal irradiation dose values of a radioactive source to a target tumor. A detector has the advantages of being good in instantaneity, small in volume, high in sensitivity and stability, easy to integrate and the like. Simultaneously, a high dose rate brachytherapy system integrating the body cavity inner dose sensor is further provided.
Description
Technical field
The present invention relates to dose detector (In vivo dose detector) in a kind of body cavity in the radiotherapy dosage detection field, can be applicable to high dose rate brachytherapy system (High Dose Rate Brachytherapy).The present invention also can be applicable to other brachytherapy system (Brachytherapy) such as middle dose rate brachytherapy (Middle Dose Rate Brachytherapy), LDR brachytherapy (Low Dose Rate Brachytherapy), suitable type brachytherapy system (Conformal Brachytherapy) and pulse wave source brachytherapy system (Pulse Source Brachytherapy) etc.
Background technology
The diagnosis that develops into tumour, treatment and the prevention of radiotherapy equipment provide efficiently easily means.Radiotherapy equipment can be divided into two kinds according to the mode of penetrating: the brachytherapy system (Brachytherapy) that the radiotherapy system that external telecurie irradiation is used (Telet herapy) reaches in body cavity or interstitial irradiation uses.
The brachytherapy instrument refers to packaged radioactive source near body cavities is placed on the tumour body or the surface, or the small needle tube transplanting is imported the radiotherapy technology general name that radiographic source implement to shine in the tumour body.In Dec, 1892, the Curies have found radium, are used for the treatment of malignant tumour of skin in 1904, have started the beginning of brachytherapy.Because radioactive protection is difficulty relatively, so that the brachytherapy slower development.Since 1980, the development and improvement of dress device technology (Afterloader) after the short distance treatment is so that the brachytherapy system is revived.
Different from external beam radiotherapy treatment, brachytherapy can provide required radiological dose within extremely short treatment time, greatly reduces the radiotherapy distance, and presses close to tumor tissues, thereby reduced the radiation insult of tumour normal surrounding tissue.The injury that these characteristics bring the patient with treatment drops to minimum, and they can be got back in the daily life quickly go, therefore be applied to more and more widely in the middle of the oncotherapy.
According to the exposure dose rate size of employed radionuclide source, brachytherapy can be divided into: high dose rate brachytherapy, dose rate＞12Gy/ hour; Middle dose rate brachytherapy, dose rate=2-12Gy/ hour; The LDR brachytherapy, dose rate=0.4-2Gy/ hour.Wherein therefore the high dose rate brachytherapy has reduced medical and nursing work personnel's workload because treatment time lacks and need not be in hospital, and becomes the Main Trends of The Development of current brachytherapy.
In high dose rate brachytherapy process, at first be placed in the body cavity near the suitable position tumour with the applicating device (Applicator) of conduit (Catheter), then confirm by ultrasonic or x-ray film making.Determine therapeutic scheme according to the pathology situation again, by specific coordinate reconstruction mode, determine source positions with the simulated emission source, adjust exposure dose, obtain rational dosage and distribute.Then, start after dress device switch packaged radioactive source is delivered to the radiotherapy that parked position (dwell positions) that treatment planning systems calculates is estimated residence time (dwell times) automatically by the conduit of applicating device.After treatment finished, radioactive source was got back in the source storage device automatically.
At present, existing associated companies is produced HDR brachytherapy system in the world, the OncoSystem that produces such as Dutch Nucletron Medical Instruments company
TMThis system can with radioactive source accurately the parked position in the implant patient body carry out radiotherapy.But brachytherapy system of this system ex hoc genus anne has a significant shortcoming: all adopt body cavity external dose sensor at patient's body surface the dosage that radioactive source shines target tumor to be surveyed, and compare with the radioactive source intracavitary irradiation dosage that treatment plan is calculated.Yet a large amount of tissues between tumour and the patient's body surface have seriously reduced the actual accurate detection that shines target tumor dosage of radioactive source the impact of radioactive source, have increased the risk of brachytherapy.
In sum, how the accurate detection radioactive source shines the dosage on the target tumor in Patients During Radiotherapy, reducing and avoid because dosage is surveyed the inaccurate malpractice that causes (such as the excessive or too small infringement that target tumor and surrounding tissue thereof are caused of radioactive source exposure dose etc.), is the problem that solution is needed in present brachytherapy field badly.
Therefore, will have in the super undersized chamber dose sensor with brachytherapy the system integration be in the same place, realize that radioactive source shines the Real-Time Monitoring of the dosage on the target tumor, be that wound of the present invention is ground motivation.The present invention can significantly reduce the risk of brachytherapy, thereby improves its quality assurance (Quality Assurance, QA).
Summary of the invention
The present invention is intended to solve the problem of above-mentioned dose measurement, a kind of " being integrated in the interior dose detector of body cavity of brachytherapy system " proposed, this detector enters in the patient's body cavity by the conduit of applicating device, and the dosage that the radioactive source in the HDR brachytherapy process is shone the tumour target carries out real-time detection.This sensor has the characteristics such as volume is little, highly sensitive, stability is high and easy of integration.
Dose detector chip of the present invention can adopt the bias voltage that has that is operated under the photovoltaic mode to drive (Applied Voltage Bias) or do not have semiconductor diode, metal oxide layer semiconductor field effect transistor (the Metal Oxide Semiconductor Field-effect Transistor that bias voltage drives, MOSFET) or thermoluminescent diode (Thermal Luminescent Diode, TLD).
Described dose sensor chip (seeing accompanying drawing 2A) is connected to electro static instrument or the upper reading out data of other current/voltage measuring instruments (seeing accompanying drawing 2D) by a pair of plain conductor (seeing accompanying drawing 2C) that is encapsulated in the flexible sheath (seeing accompanying drawing 2B).Wherein sheath can be made by insulating material such as dacron or nylon.
Described Wire sheath accurately determines the position of detector by a plurality of set collars, and wherein the set collar material can be the metals such as titanium or nickel.(seeing accompanying drawing 2E)
Described detector chip is fixed on the substrate (seeing accompanying drawing 2F) by upside-down mounting drought chip technology (Flip-chip) or elargol (Silver glue).Substrate can adopt the flexible materials such as the thick polyimide of 100um (Polyimide).Wherein substrate has the couple of conductor hole, can make wire pass substrate and be connected on the detector chip.
The high dose rate brachytherapy system of dose sensor comprises in the integrated chamber: the radioactive source particle that implantable body cavity is interior, radioactive source particle by rear dress device control, enter in the body cavity by one of them conduit of applicating device, and determined parked position carries out radiotherapy to target in therapeutic scheme; The dose sensor probe that implantable body cavity is interior, probe enters in the body cavity by another conduit of applicating device, and target is carried out dosage survey; An electro static instrument test macro can be used for the dosage that probe measures is converted to voltage or current signal record, preserves.
Described system comprises calculating treatment and puts in the case method of intended dose (planned dose) on each parked position.
Described system comprise calculating radioactive source in the therapeutic scheme the method for all locational complete integration intended dose (integrated planned dose) of process.
Described system comprises a comparer, and this comparer is on given parked position, and the intended dose of calculating in the actual dose that detector is measured and the therapeutic scheme is compared and exported comparative result.
Described system comprises a comparer, this comparer penetrate the source on all positions of process, the complete integral absorbed dose of plan of calculating in the actual complete integral absorbed dose that detector is measured and the therapeutic scheme is compared and is exported comparative result.
Described system comprises that a reporting system is used for accepting and storing the signal of comparer output.This report system is used to receive patient's alert consitions simultaneously, and when the output signal of comparer was conflicted with patient's alert consitions, described reporting system can start emergency procedure.
A kind of the high dose rate brachytherapy is carried out the method for dose measurement in the body cavity, the method comprises: two conduits that dose sensor probe in radioactive source particle and the body cavity will be housed are implanted simultaneously in the body cavity and are placed and are treated on the target; The radioactive source particle is moved in the treatment plan on the defined parked position by conduit, target tumor is carried out radiotherapy; Sensor probe is moved on the detecting location in the therapeutic purpose by conduit, the dosage that shines target tumor of radioactive source on parked position is measured.
Description of drawings
Accompanying drawing, it is incorporated into and becomes the part of this instructions, the embodiments of the invention of having demonstrated, and explain principle of the present invention with aforesaid summary and following detailed description.
Fig. 1 is the applicating device pictorial diagram that is applied to the HDR brachytherapy.
Fig. 2 is dose sensor probe synoptic diagram in the chamber
Fig. 3 is semiconductor diode dose sensor probe manufacturing flow scheme one
Fig. 4 is semiconductor diode dose sensor probe manufacturing flow scheme two
The HDR brachytherapy system schematic of the interior dose detector of body cavity that Fig. 5 has been integrated.
The angle anisotropy synoptic diagram of Fig. 6 sensor.
Fig. 7 is HDR brachytherapy system operational flowchart.
Embodiment
For so that the content of technical scheme of the present invention is more clear, be described in detail the specific embodiment of the present invention below in conjunction with technical scheme and accompanying drawing.
The applicating device A that shown in Figure 1 is for the rectal neoplasm brachytherapy, described applicating device front end is aseptic anal tube B, and it will insert in the rectum by patient's anus, and it can detect by imaging systems such as ultrasonic or x-ray in endoceliac position.Vessel cluster C is connected with aseptic anal tube, and the quantity of conduit is 8, and diameter is 1.2mm, and its quantity can increase or reduce according to actual conditions.Support seat D fixes endoceliac anal tube near patient's body surface in therapeutic process.Packaged radioactive source Ir192 enters in the body cavity by the conduit in the applicating device target tumor is carried out radiotherapy.
The problem of above-mentioned brachytherapy is to be difficult to detect the actual dosage that shines target tumor and neighboring area thereof of radioactive source.In order to address this problem, this patent has proposed dose sensor probe in a kind of chamber that can be integrated in conduit in the applicating device:
Example 1
At first, at upper growing metal film (such as Al, Ag, Au, the Cu etc.) C of the flexible material substrate D such as the thick polyimide of 100um (Polyimide), shown in accompanying drawing 3 (a).Secondly, utilize upside-down mounting drought chip technology (Flip-chip) or elargol (silver glue) B that semiconductor diode dose sensor chip A is fixed on metallic film (such as Al, Ag, Au, the Cu etc.) C, shown in accompanying drawing 3 (b).Then, with semiconductor diode dose sensor chip package in a kind of radiation permeable material, among polyethylene catheter (Polythene/Polyethylene Tube) E such as light-permeable, form dose sensor probe F, wherein fill by hydrocolloid (water like glue) G among the conduit E, shown in accompanying drawing 3 (c).At last, the conduit with in the dose sensor probe F insertion applicating device forms the conduit H that dose sensor probe F in the body cavity is housed, shown in accompanying drawing 3 (d).
Example 2
At first, respectively at two flexible material substrate D1 and D2 upper growing metal film (such as Al, Ag, Au, Cu etc.) C1 and C2 such as polyimide (Polyimide) that 100um is thick, shown in accompanying drawing 4 (a).Secondly, utilize upside-down mounting drought chip technology (Flip-chip) or elargol (silver glue) B that semiconductor diode dose sensor chip A1 and A2 are separately fixed on metallic film (such as Al, Ag, Au, Cu etc.) C1 and the C2, shown in accompanying drawing 4 (b).Then, the substrate D1 of two semiconductor diode chips pasted with D2 be in the same place, form two-sided diode dose sensor chip, shown in accompanying drawing 4 (c).Then, with described two-sided diode dose sensor chip package in a kind of radiation permeable material, among polyethylene catheter (Polythene/Polyethylene Tube) E such as light-permeable, form two-sided dose sensor probe F, wherein fill by hydrocolloid (water like glue) G among the conduit E, shown in accompanying drawing 4 (d).At last, the conduit with in the probe F insertion applicating device forms the conduit H that two-sided dose sensor probe F in the body cavity is housed, shown in accompanying drawing 4 (e).
Therefore diameter＜the 1mm of described dose sensor probe can insert the conduit in the applicating device and enters in the body cavity with conduit, and the dosage size and the distribution that radioactive source are shone target tumor are measured in real time.
As shown in Figure 2, the sensor chip A at sensor probe top can detect the exposure dose of radioactive source and produce a voltage or current signal, and this signal is input on the outer electro static instrument D of patient body by plain conductor C and reads.
Wire C passes substrate F, is directly connected on the sensor chip A.Sensor chip A then is fixed on the substrate F by the flip-chip solder technology.
Substrate F is a kind of flexible material, such as the thick polyimide of 100um.Sensor chip can adopt the bias voltage that has that is operated under the photovoltaic mode to drive (Applied Voltage Bias) or do not have the semiconductor diode that bias voltage drives, also can adopt metal oxide layer semiconductor field effect transistor (Metal Oxide Semiconductor Field-effect Transistor, MOSFET) or thermoluminescent diode (Thermal Luminescent Diode, TLD).
This patent will be set forth as an example of the semiconductor diode dose sensor example.The output of described diode dose sensor and the exposure dose of radioactive source are linear.Electro static instrument D will measure the charge number that semiconductor diode dose sensor in the unit interval produces.
The wire C of connecting sensor chip A is encapsulated in the flexible sheath B, and the other end of wire is connected on the substrate F with plug H, thereby wire can be connected on the electro static instrument D by concentric cable G.The material of described sheath can be the insulating material such as dacron or nylon, and described wire C has enamel paint coating (enamel coated).
Described sheath will accurately be fixed in the body cavity by a plurality of titaniums or nickel metal set collar E, and can determine its position by ultrasonic or x-ray imaging system.
The HDR brachytherapy system schematic of the interior dose detector of body cavity that Fig. 5 has been integrated.At first, dose sensor probe A is inserted into one in applicating device conduit B that is not used in the chamber, enters C in the patient's body cavity.The other end of probe is connected to external electro static instrument D and reads interior charge number of unit interval.In therapeutic process, described sensor probe will be fixed on the position of a known coordinate in the patient's body cavity, and packaged radioactive source particle will be with respect to the position movement of sensor probe.
The movement of radioactive source is to control by rear dress device.Then filling device is to be driven by the computer system that has read in advance treatment plan.
Treatment planning systems E in the described system links to each other with the dose data storehouse F of system, produces treatment plan.This treatment plan comprises that mainly radioactive source is at endoceliac parked position (dwell positions) " r " and residence time (dwell times) " t ".Treatment plan for fear of doctor's approval is covered or revises by mistake, and the dose data storehouse F of system only has the right of reading to treatment planning systems E.
Interface is to intended dose analyzer G simultaneously for the dose data storehouse F of system, and intended dose analyzer G can calculate intended dose D (r, t) relevant with residence time (dwell times) " t " with parked position " r " on each parked position.Intended dose analyzer G can calculate the integral absorbed dose ∫ D (r, t) in the patient body simultaneously, and namely radioactive source shines the overall dose of target tumor in HDR brachytherapy process.Therefore, intended dose analyzer G can export one at each parked position and represent the signal of intended dose and the signal of a representative plan overall dose.
Because the detectivity of dose sensor is relevant with the placement direction of the relative radioactive source of sensor in the chamber, so it has very big-difference to the detection that is in the identical radioactive source exposure dose of different parked positions in the body cavity, i.e. the angle anisotropy of sensor.As shown in Figure 6, be in different parked position r
1, r
2, r
3The exposure dose of radioactive source particle A be identical, but the angle anisotropy of detector B can make the r that is in that detector detects
1And r
3The dosage of radioactive source is greater than r
2The radioactive source dosage at place.Therefore, for actual dose detect consistent, intended dose analyzer proposed by the invention (accompanying drawing 5G) calculating be positioned at r
2The intended dose at place is less than and is positioned at r
1And r
3The intended dose at place.
Time device H as shown in Figure 5 is connected on the F of system of dose data storehouse, is used for measuring on each parked position the periodicity of radioactive source residence time.Electro static instrument D links to each other with dose sensor probe A in the body cavity simultaneously, and with the formal output Q (t) of the measured dosage of probe A with charge number.This charge number and unit residence time internal source are linear at the dosage that each parked position shines.
Intended dose D (the r that the charge number Q that electro static instrument D detects (t) and intended dose analyzer G calculate, t) (the angle anisotropy is revised) will compare by comparer I, thereby can detect in real time on each parked position the difference of the actual exposure dose that the intended dose of radioactive source and target tumor are accepted.Comparer equally also can be compared with overall planning dosage to overall actual exposure dose.
The comparative result of above-mentioned comparer will be imported among the reporting system K with patient's alert consitions J.Alert consitions J has defined the emergency condition in the brachytherapy process, and when emergency condition occured, treatment should stop, and radioactive source is wanted to withdraw from the patient body at once.Described alert consitions J has mainly set the upper and lower bound of radioactive source in each parked position exposure dose, has also set simultaneously the exposure dose rate scope of radioactive source, such as the normal dose rate+/-5% scope.If above-mentioned emergency condition does not occur, can continue in the therapeutic process to carry through to the end.Reporting system K will note down in the whole therapeutic process, dosage and dose rate that radioactive source shines in each parked position reality, and offer the doctor.
Each functional module of Fig. 5 can be discrete or integrated.Such as, time device module, electro static instrument module and comparator module can be integrated on the integrated circuit (IC) chip simultaneously shown in dotted line frame L.
For security and the integrality that guarantees data, treatment planning systems, rear dress device control system, reporting system and dose measurement system can be by four different computer control.Thereby avoid between the said system that the data transmission is obscured, the problem such as covering and change.
The HDR brachytherapy system operational flowchart of dose sensor probe in the body cavity that has been integrated shown in Figure 7.When therapeutic process begins (accompanying drawing 7A), to at first import dosage database and alert consitions (accompanying drawing 7B), afterwards the initial parked position of radioactive source is imported to the computer control system (accompanying drawing 7C) of rear dress device, judge radioactive source implantation position whether accurately (accompanying drawing 7E) by ultrasonic or X-ray imaging system, if the correct time device begins timing (accompanying drawing 7F), near the initial parked position that rear dress device is implanted radioactive source the target tumor fast carries out radiotherapy (accompanying drawing 7G).Simultaneously, the overall dose (Q (t), ∫ Q (t)) of radioactive source in actual exposure dose, dose rate and the therapeutic process of initial parked position will be detected in real time by dose sensor in the chamber (accompanying drawing 7H).
The radioactive source that sensor is detected in real time is in the actual exposure dose of initial parked position, overall dose in dose rate and the therapeutic process (Q (t), ∫ Q (t)) with treatment plan in intended dose, intended dose rate and plan overall dose (D (t), ∫ D (t)) compare (accompanying drawing 7I), if the radioactive source that sensor detects in real time is in the actual exposure dose of initial parked position, overall dose in dose rate and the therapeutic process has surpassed intended dose in the alert consitions, the scope (accompanying drawing 7J) of intended dose rate and plan overall dose, system will report to the police (accompanying drawing 7K), radioactive source can be withdrawn from (accompanying drawing 7L) in the patient body, therapeutic process stops (accompanying drawing 7M).
If measured dosage is lower than intended dose, system will at first judge by the time device whether the irradiation time of radioactive source reaches plan residence time (t
x).If the radioactive source irradiation time is less than plan residence time (accompanying drawing 7N), radioactive source will be proceeded radiotherapy to destination organization.If the radioactive source irradiation time equates that with the plan residence time time device will be reset, and judges the parked position (r that whether also comprises other in the treatment plan
x) (accompanying drawing 70).If comprise, the parked position (accompanying drawing 7P) of next radioactive source can be read in system, and repeats above-mentioned treatment flow process.When radioactive source is finished it after the irradiation on all parked positions, therapeutic process finishes, and radioactive source is withdrawn from external.The metering that records and intended dose will be stored into reporting system and the later reference data of formulating treatment plan of conduct.
Under in the body cavity in the system output electrical signals of dose detector can read by traditional electro static instrument, thereby the detector actual detection arrives near the overall absorption dosage (total integrated absorbed dose) of target tumor, integrated time resolution absorbed dose (integrated and time-resolved absorbed dose), the target tumor absorbed dose (absorbed dose), dose rate (dose rate) and the chamber dosage and the comparative result of intended dose are provided.
In sum, diameter provided by the invention can successfully insert the conduit of applicating device less than dose sensor probe in the chamber of 1mm, carries out dose measurement near endoceliac target tumor; Simultaneously, the present invention has also proposed the brachytherapy system of dose sensor in the chamber integrated, thereby has significantly improved the quality assurance of brachytherapy system.
The above is know-why and instantiation that the present invention uses, the equivalent transformation of doing according to conception of the present invention, as long as when its scheme of using does not exceed spiritual that instructions and accompanying drawing contain yet, and all should be within the scope of the invention, hereby explanation.
Claims (13)
1. dose sensor probe in the body cavity that is used for high dose rate brachytherapy process (High Dose Rate Brachytherapy), it is characterized in that: can insert in the applicating device conduit and by applicating device and plant in patient's body cavity, realize that radioactive source is to the real-time detection of the body cavity internal dose value of target tumor.
2. described dose sensor chip can adopt the bias voltage that has that is operated under the photovoltaic mode to drive (Applied Voltage Bias) or do not have semiconductor diode, metal oxide layer semiconductor field effect transistor (the Metal Oxide Semiconductor Field-effect Transistor that bias voltage drives, MOSFET) or thermoluminescent diode (Thermal Luminescent Diode, TLD).
3. described dose sensor can be divided into single face or two-sided, and two-sided dose detector wherein is to be pasted together formation by the substrate bottom surface with two discrete detector chips.
4. described dose sensor is connected to the outer electro static instrument reading out data of patient body by a pair of plain conductor that is encapsulated among the flexible sheath, and wherein the material of sheath can be the insulating material such as dacron or nylon.
5. above-mentioned Wire sheath adopts a plurality of rings to come the position of accurate fixation of sensor, and wherein the material of ring can be the metals such as titanium or nickel.
6. described sensor is fixed on the substrate by upside-down mounting drought chip technology (Flip-chip) or elargol (silver glue).Substrate can adopt the flexible materials such as the thick polyimide of 100um (Polyimide).Wherein have the couple of conductor hole on the substrate, can make wire pass substrate and be connected on the detector.
7. the high dose rate brachytherapy system (High Dose Rate Brachytherapy) of dose sensor probe comprises in the integrated body cavity: the conduit that the radioactive source particle is housed that implantable body cavity is interior, radioactive source by afterloading unit (afterloader) control enters in the body cavity by described conduit, and determined parked position (dwell positions) carries out radiotherapy to target in therapeutic scheme; The conduit that the dose sensor probe is housed that implantable body cavity is interior, probe enters in the body cavity by conduit, and the intracavitary irradiation dosage that target tumor is accepted is surveyed; A test macro can be used for the dosage size that survey sensor measures at described radioactive source parked position (dwell positions).
8. described system has the method that the upper intended dose (planned dose) of each parked position in the case (dwell position) is put in the treatment of calculating.
Described system have to calculate radioactive source in the therapeutic scheme the method for all locational complete integration intended dose (integrated planned dose) of process.
10. described system comprises a comparer, and this comparer is (dwell position) on given stop place, and the intended dose of calculating in the actual dose that sensor is measured and the therapeutic scheme is compared and exported comparative result.
11. described comparer can also be on all positions of radioactive source process, the complete integral absorbed dose (integrated planned dose) of calculating in the actual complete integral absorbed dose that detector is measured (integrated measured dose) and the therapeutic scheme is compared and is exported comparative result.
12. described system comprises that a reporting system is used for accepting and storing the output signal of comparer.This report system receives patient's alert consitions simultaneously, and when the output signal of comparer was conflicted with patient's alert consitions, described reporting system can start emergency procedure.
13. one kind is carried out the method for dose measurement in the body cavity to the high dose rate brachytherapy, the method comprises: two conduits that radioactive source and dose sensor probe are housed are respectively implanted simultaneously in the body cavity and placed be treated on the target; Described radioactive source moved to carry out radiotherapy in the treatment plan on the defined stop place; Described sensor probe is moved on the detecting location in the therapeutic purpose, the dosage that radioactive source radiates in the stop place is measured.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102658801A CN102967872A (en) | 2011-08-31 | 2011-08-31 | Body cavity inner dose detector integrated in brachytherapy system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102658801A CN102967872A (en) | 2011-08-31 | 2011-08-31 | Body cavity inner dose detector integrated in brachytherapy system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102967872A true CN102967872A (en) | 2013-03-13 |
Family
ID=47798141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011102658801A Pending CN102967872A (en) | 2011-08-31 | 2011-08-31 | Body cavity inner dose detector integrated in brachytherapy system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102967872A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103268622A (en) * | 2013-05-21 | 2013-08-28 | 南方医科大学 | Method for generating distribution image for observing cervix tumor radiotherapy total dose |
| CN106581873A (en) * | 2016-12-07 | 2017-04-26 | 上海交通大学医学院附属第九人民医院 | Radioactive dose detection method and radioactive dose detection device |
| CN112755412A (en) * | 2021-02-26 | 2021-05-07 | 张宏涛 | External measuring device and method for radioactive particle implantation dose |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1901969A (en) * | 2003-11-07 | 2007-01-24 | Cytyc公司 | Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods |
| CN201945691U (en) * | 2011-02-16 | 2011-08-24 | 上海市第一人民医院 | Sensor for detecting X-ray dose |
-
2011
- 2011-08-31 CN CN2011102658801A patent/CN102967872A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1901969A (en) * | 2003-11-07 | 2007-01-24 | Cytyc公司 | Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods |
| CN201945691U (en) * | 2011-02-16 | 2011-08-24 | 上海市第一人民医院 | Sensor for detecting X-ray dose |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103268622A (en) * | 2013-05-21 | 2013-08-28 | 南方医科大学 | Method for generating distribution image for observing cervix tumor radiotherapy total dose |
| CN106581873A (en) * | 2016-12-07 | 2017-04-26 | 上海交通大学医学院附属第九人民医院 | Radioactive dose detection method and radioactive dose detection device |
| CN110354403A (en) * | 2016-12-07 | 2019-10-22 | 上海交通大学医学院附属第九人民医院 | Radiopharmaceutical agent amount detector |
| CN110354403B (en) * | 2016-12-07 | 2021-09-17 | 上海交通大学医学院附属第九人民医院 | Radioactive dose detection device |
| CN112755412A (en) * | 2021-02-26 | 2021-05-07 | 张宏涛 | External measuring device and method for radioactive particle implantation dose |
| CN112755412B (en) * | 2021-02-26 | 2022-10-11 | 张宏涛 | External measuring device and method for radioactive particle implantation dose |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7831016B2 (en) | Radiation dosimetry apparatus and method, and dosimeter for use therein | |
| Tanderup et al. | In vivo dosimetry in brachytherapy | |
| EP2688647B1 (en) | Apparatus for electronic brachytherapy | |
| US8790234B2 (en) | Brachytherapy system and in vivo dose detector therefor | |
| Suchowerska et al. | Clinical trials of a urethral dose measurement system in brachytherapy using scintillation detectors | |
| US20090018403A1 (en) | Trackable implantable sensor devices, systems, and related methods of operation | |
| CN101282760A (en) | Medical treatment system and method using radioactivity based position sensor | |
| US20220175327A1 (en) | System and method for detecting radiation | |
| CN102967872A (en) | Body cavity inner dose detector integrated in brachytherapy system | |
| Houlihan et al. | In vivo dosimetry in pelvic brachytherapy | |
| US12011248B2 (en) | Multi-detector personalized home dosimetry garment | |
| Pittet et al. | Dosimetry systems based on Gallium Nitride probe for radiotherapy, brachytherapy and interventional radiology | |
| US8295910B1 (en) | Imaging method for monitoring delivery of high dose rate brachytherapy | |
| WO2013120795A2 (en) | Brachytherapy system & in vivo dose detector therefor | |
| Bravo-Miranda et al. | Measurement of rectum dose by in vivo alanine/ESR dosimetry in gynecological 192Ir HDR brachytherapy | |
| Bollinger et al. | Clinical considerations and dosimeters for in vivo dosimetry | |
| Buzurovic et al. | Commissioning and implementation of an implantable dosimeter for radiation therapy | |
| Johan et al. | In-vivo Comparison of Planned and Measured Rectal Doses during Cobalt-60 HDR CT-based Intracavitary Brachytherapy Applications of Cervical Cancer Using the PTW 9112 Semiconductor Probe | |
| Peters | Wireless In-Vivo Dosimetry of High Dose Rate Brachytherapy for Prostate Cancer using MOSkin Detectors | |
| Wootton et al. | In vivo dosimetry I: External beam radiation therapy | |
| Rokni | Brachytherapy Dosimetry: Working towards real-time treatment verification in modern HDR brachytherapy | |
| Al-Qadhi | Characterisation of New N-Type Epitaxial Skin Diode Detector for Radiotherapy | |
| Beeksma | Source tracking and quality assurance of high dose rate (HDR) brachytherapy | |
| CN101534866A (en) | A system for determining a distribution of radioactive agents in a subject | |
| Bhagwat et al. | Technical Aspects of Brachytherapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Cao Tun Document name: the First Notification of an Office Action |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130313 |