CN102956035A - Preprocessing method and preprocessing system used for extracting breast regions in mammographic images - Google Patents
Preprocessing method and preprocessing system used for extracting breast regions in mammographic images Download PDFInfo
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Abstract
The invention discloses a preprocessing method and a preprocessing system used for extracting breast regions in mammographic images. The method includes steps: subjecting the mammographic images to automatic threshold segmentation to obtain binary images; subjecting communicated regions in the binary images to filling processing to remove labels and holes in the mammographic images; dividing the binary images into a plurality of subregions, and binarizing each subregion according to local threshold value to position breast contour regions; subjecting the binary images and the breast contour regions to set 'and' operation, searching number of pixel points in each subregion containing difference in the binary images along a reference line from top to bottom, and positioning the subregion with maximum number of pixel points in regions containing difference to be nipple regions. By overall automatic threshold segmentation and local threshold analysis, the breast regions and the nipple regions in the mammographic images can be accurately positioned, the preprocessing process is low in computation complexity, and execution efficiency is high.
Description
Technical field
The present invention relates to a kind of medical image processing method, especially relate to a kind of preprocess method and system that extracts the mammary gland zone for the mammary X-ray image.
Background technology
The frequent deficiency of former sharpness of mammary X-ray image (mammography) and contrast is diagnosed the state of an illness better in order to help the clinician, need to carry out image processing and enhancing to former.Yet there are the interfere informations such as background, label in the mammary X-ray image, and different breast area, and the image property difference is larger, needs to use different enhancing algorithms to process.Therefore need to carry out pre-service to the original galactophore image of input and cut apart.
Present mammary X-ray image segmentation algorithm is simple single Threshold segmentation mostly, and the breast area precision that obtains is not good, and the edge is more coarse.
The Chinese patent application of application number 200910100655.5, a kind of preprocess method for mammograms mammary gland extracted region is proposed, the method is by distributing to judge the position of mammary gland zone in image with left and right sides picture element density in median filter method and the image simply, and then usage level is peeled off with vertical unexposed frame and obtained final breast area.But the method can't be distinguished nipple area, easily produces jagged edge at the breast profile.
The Chinese patent application of application number 200810217937.9 proposes a kind of method of definite external periphery outline of mammary gland, and the method is used the technology such as image centroid extraction, image binaryzation and region growing, determines external periphery outline of mammary gland.But the method can't be located nipple area and matter Mi Qu, and uses region-growing method to make easily the image border unsmooth, produces jagged edge at the breast profile easily, and jagged edge can cause interference to follow-up processing and diagnosis.
Summary of the invention
The present invention proposes a kind of preprocess method and system that extracts the mammary gland zone for the mammary X-ray image, by removing background and the label of x-ray image, adopt overall automatic threshold segmentation and local Threshold Analysis accurately to locate and get mammary gland zone and nipple area in the mammary X-ray image, have at present the technical matters that can't accurately locate nipple area to solve.
The present invention adopts following technical scheme to realize: a kind of preprocess method for mammary X-ray image extraction mammary gland zone, and it comprises step:
The mammary X-ray image is carried out automatic threshold segmentation, obtain binary image, by datum line binary image is divided into mammary gland zone and background area;
Processing is filled in mammary gland zone and background area, remove label and hole in the mammary X-ray image;
Centered by datum line, binary image is divided into several subregions, every sub regions is carried out binaryzation by local threshold, orient the breast contour area;
Binary image and breast contour area are gathered AND-operation, obtain the difference zone between skin in datum line and the breast contour area-air separatrix, and search for the quantity that comprises pixel in the difference zone in the binary image in each sub regions from top to bottom along datum line, will comprise the subregion that pixel quantity is maximum in the difference zone and orientate nipple area as;
Wherein, datum line is that the binary image intermediate value be 1 pixel with value is the separatrix of 0 pixel; The edge in mammary gland zone is skin-air separatrix.
In a preferred embodiment, described method also comprises step:
Take nipple area as separation, skin in the breast contour area-air separatrix is divided into up and down two parts;
Respectively two parts are up and down carried out curve fitting, the use curve fitting result replaces the existing edge in the breast contour area.
Wherein, described step of carrying out automatic threshold segmentation comprises:
Use Otsu overall situation adaptive thresholding algorithm to produce the global threshold of mammary X-ray image;
According to global threshold the mammary X-ray image is carried out binary conversion treatment, produce binary image BI, wherein, pixel 1 is called datum line with the separatrix of pixel 0 in the binary image.
Wherein, the label in the described removal mammary X-ray image and the step of hole comprise:
The quantity of pixel 0 is more in which zone of judgment standard line the right and left, and which side belongs to the mammary gland zone to distinguish the datum line both sides, and which side belongs to the background area;
The upset binary image make the background area in the left side of datum line, and the mammary gland zone is on the right side of datum line;
Process line by line, with the whole assignment 1 of the value of all pixels in the background area on the datum line left side, and with the whole assignment 0 of value of all pixels in the mammary gland zone on datum line the right.
Wherein, local threshold is the average pixel value of each pixel in the subregion.
In addition, the present invention also discloses a kind of pretreatment system for mammary X-ray image extraction mammary gland zone, and it comprises:
The global threshold analysis module is used for the mammary X-ray image is carried out automatic threshold segmentation, obtains binary image, by datum line binary image is divided into mammary gland zone and background area;
Connected region is filled processing module, is used for processing is filled in mammary gland zone and background area, removes label and hole in the mammary X-ray image;
The local threshold analysis module is used for centered by datum line binary image being divided into several subregions, and every sub regions is carried out binaryzation by local threshold, orients the breast contour area;
The nipple area locating module, be used for binary image and breast contour area are gathered AND-operation, obtain in the binary image zone of the difference between skin-air separatrix in the datum line and breast contour area, and search for the quantity that comprises pixel in the difference zone in the binary image in each sub regions from top to bottom along datum line, will comprise the subregion that pixel quantity is maximum in the difference zone and orientate nipple area as;
Curve smoothing processing module, be used for take nipple area as separation, skin in the breast contour area-air separatrix is divided into up and down two parts, respectively two parts is up and down carried out curve fitting, the use curve fitting result replaces the existing edge in the breast contour area.
Compared with prior art, the present invention has following beneficial effect:
The present invention will accurately locate by overall automatic threshold segmentation and local Threshold Analysis and get mammary gland zone and nipple area in the breast X-ray image, and remove the edge sawtooth of breast profile by the mode of curve, improve follow-up mammary gland extracted region and carried out efficient and implementation effect.Whole preprocessing process computation complexity of the present invention is very low, has very high execution efficient.
Description of drawings
Fig. 1 is schematic flow sheet of the present invention;
Fig. 2 is the synoptic diagram of mammary X-ray image;
Fig. 3 is the synoptic diagram of binary image corresponding to mammary X-ray image;
Fig. 4 is the synoptic diagram of mammary gland Region Segmentation;
Fig. 5 is system architecture synoptic diagram of the present invention.
Embodiment
As shown in Figure 1, extract the preprocess method in mammary gland zone in the mammary X-ray image that the present invention proposes, it comprises following performing step:
Step S11, the mammary X-ray image is carried out automatic threshold segmentation, produce datum line.
The mammary X-ray image of input as shown in Figure 2.At first, use Otsu overall situation adaptive thresholding algorithm to produce the global threshold T of mammary X-ray image, then, according to global threshold T the mammary X-ray image is carried out binary conversion treatment, produce a width of cloth binary image BI, as shown in Figure 3.Wherein, in binary image BI, pixel 1 is shown as white, sign background (air) part; Pixel 0 is shown as black, sign mammary gland zone; And pixel 1 is called datum line (Baseline) with the separatrix of pixel 0, as shown in Figure 4.
In addition, in binary image BI, the black region among the bianry image BI (being the mammary gland zone) white portion (background area) is regarded two connected regions as.
Step S12, the connected region among the bianry image BI fill is processed, used the connected domain filling algorithm to remove label and hole in the mammary X-ray image.
What produce when having some assorted points (such as the intrinsic label of mammary X-ray image and binaryzation time produce hole) label and binaryzation in two connected regions of black and white among the binary image BI that produces through step S11 is assorted as hole.White connected region (background area) and black connected region (mammary gland zone) inner area are less than the assorted point of A among the use connected region filling algorithm removal binary image BI, and A is that set-point changes with mammary gland original image size variation.
In addition, a comparatively simple disposal route is: at first, and the quantity of pixel 0 more (namely take datum line as the separatrix, which side belongs to the mammary gland zone to distinguish the datum line both sides, and which side belongs to the background area) in which connected region of judgment standard line the right and left; Then, adjust (upset) binary image BI and reach the background area in the left side of datum line, and the mammary gland zone is on the right side of datum line; Then process line by line the whole assignment 1 of the value of all pixels in the background area on the datum line left side, and the whole assignment 0 of value of all pixels in the mammary gland zone on datum line the right.
Step S13, binary image BI is carried out the local threshold analysis, obtain local threshold analysis result image.
Near the datum line image-region is divided the subregion of several K * K pixel from top to bottom along datum line, K is a set-point (such as K=300), and the center of every sub regions is all on datum line; Get a local threshold (for example pixel average of each pixel in every sub regions) for every sub regions and carry out binaryzation, thereby the breast area in the x-ray image is carried out further refinement.This process will be oriented comparatively accurate breast contour area (being the mammary gland zone), and the edge in mammary gland zone is called skin-air separatrix (Skin Air Interface).
Step S14, location nipple area.
At first, binary image BI and local threshold analysis result image are gathered AND-operation, obtain the difference zone between datum line and skin-air separatrix; Then, search for the quantity that comprises pixel in the difference zone in each sub regions from top to bottom along datum line, wherein, comprising the subregion that pixel quantity is maximum in the difference zone is nipple area.
Step S15, curve refinement edge
Take nipple area as separation, skin-air separatrix is divided into up and down two parts, respectively two parts are up and down carried out curve fitting, the use curve fitting result replaces existing edge.Therefore, utilize curve to eliminate the edge sawtooth of breast profile, so that the breast profile is Paint Gloss.
In conjunction with shown in Figure 5, the pretreatment system that is used for mammary X-ray image extraction mammary gland zone that the present invention proposes, it comprises: the global threshold analysis module that is used for execution in step S11; The connected region that is used for execution in step S12 is filled processing module; The local threshold analysis module that is used for execution in step S13; The nipple area locating module that is used for execution in step S14; The curve smoothing processing module that is used for execution in step S15.
The above only is preferred embodiment of the present invention, not in order to limiting the present invention, all any modifications of doing within the spirit and principles in the present invention, is equal to and replaces and improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. one kind is used for the preprocess method that the mammary X-ray image extracts the mammary gland zone, it is characterized in that described method comprises step:
The mammary X-ray image is carried out automatic threshold segmentation, obtain binary image, by datum line binary image is divided into mammary gland zone and background area;
Processing is filled in mammary gland zone and background area, remove label and hole in the mammary X-ray image;
Centered by datum line, binary image is divided into several subregions, every sub regions is carried out binaryzation by local threshold, orient the breast contour area;
Binary image and breast contour area are gathered AND-operation, obtain the difference zone between skin in datum line and the breast contour area-air separatrix, and search for the quantity that comprises pixel in the difference zone in the binary image in each sub regions from top to bottom along datum line, will comprise the subregion that pixel quantity is maximum in the difference zone and orientate nipple area as;
Wherein, datum line is that the binary image intermediate value be 1 pixel with value is the separatrix of 0 pixel; The edge in mammary gland zone is skin-air separatrix.
2. describedly according to claim 1 extract the preprocess method in mammary gland zone for the mammary X-ray image, it is characterized in that described method also comprises step:
Take nipple area as separation, skin in the breast contour area-air separatrix is divided into up and down two parts;
Respectively two parts are up and down carried out curve fitting, the use curve fitting result replaces the existing edge in the breast contour area.
3. describedly according to claim 1 extract the preprocess method in mammary gland zone for the mammary X-ray image, it is characterized in that described step of carrying out automatic threshold segmentation comprises:
Use Otsu overall situation adaptive thresholding algorithm to produce the global threshold of mammary X-ray image;
According to global threshold the mammary X-ray image is carried out binary conversion treatment, produce binary image BI, wherein, pixel 1 is called datum line with the separatrix of pixel 0 in the binary image.
4. describedly according to claim 1 extract the preprocess method in mammary gland zone for the mammary X-ray image, it is characterized in that the label in the described removal mammary X-ray image and the step of hole comprise:
The quantity of pixel 0 is more in which zone of judgment standard line the right and left, and which side belongs to the mammary gland zone to distinguish the datum line both sides, and which side belongs to the background area;
The upset binary image make the background area in the left side of datum line, and the mammary gland zone is on the right side of datum line;
Process line by line, with the whole assignment 1 of the value of all pixels in the background area on the datum line left side, and with the whole assignment 0 of value of all pixels in the mammary gland zone on datum line the right.
5. describedly according to claim 1 extract the preprocess method in mammary gland zone for the mammary X-ray image, it is characterized in that local threshold is the average pixel value of each pixel in the subregion.
6. one kind is used for the pretreatment system that the mammary X-ray image extracts the mammary gland zone, it is characterized in that described system comprises:
The global threshold analysis module is used for the mammary X-ray image is carried out automatic threshold segmentation, obtains binary image, by datum line binary image is divided into mammary gland zone and background area;
Connected region is filled processing module, is used for processing is filled in mammary gland zone and background area, removes label and hole in the mammary X-ray image;
The local threshold analysis module is used for centered by datum line binary image being divided into several subregions, and every sub regions is carried out binaryzation by local threshold, orients the breast contour area;
The nipple area locating module, be used for binary image and breast contour area are gathered AND-operation, obtain in the binary image zone of the difference between skin-air separatrix in the datum line and breast contour area, and search for the quantity that comprises pixel in the difference zone in the binary image in each sub regions from top to bottom along datum line, will comprise the subregion that pixel quantity is maximum in the difference zone and orientate nipple area as;
Wherein, datum line is that the binary image intermediate value be 1 pixel with value is the separatrix of 0 pixel; The edge in mammary gland zone is skin-air separatrix.
7. describedly according to claim 6 extract the pretreatment system in mammary gland zone for the mammary X-ray image, it is characterized in that described system also comprises:
Curve smoothing processing module, be used for take nipple area as separation, skin in the breast contour area-air separatrix is divided into up and down two parts, respectively two parts is up and down carried out curve fitting, the use curve fitting result replaces the existing edge in the breast contour area.
8. the described pretreatment system that extracts the mammary gland zone for the mammary X-ray image according to claim 6, it is characterized in that, described global threshold analysis module uses Otsu overall situation adaptive thresholding algorithm to produce the global threshold of mammary X-ray image, and according to global threshold the mammary X-ray image is carried out binary conversion treatment, produce binary image.
9. describedly according to claim 6 extract the pretreatment system in mammary gland zone for the mammary X-ray image, it is characterized in that every sub regions is K * K pixel, wherein K is set-point.
10. describedly according to claim 6 extract the pretreatment system in mammary gland zone for the mammary X-ray image, it is characterized in that local threshold is the mean value of subregion pixel value.
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| CN113393475A (en) * | 2021-06-30 | 2021-09-14 | 神州医疗科技股份有限公司 | Mammary gland molybdenum target image segmentation device, electronic equipment, medical equipment and medium |
| CN113393475B (en) * | 2021-06-30 | 2024-02-20 | 神州医疗科技股份有限公司 | Mammary gland molybdenum target image segmentation device, electronic equipment, medical equipment and medium |
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