CN102908674A - Preparation method of stent coating with hemostasis and antibiosis functions - Google Patents
Preparation method of stent coating with hemostasis and antibiosis functions Download PDFInfo
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- CN102908674A CN102908674A CN 201210444957 CN201210444957A CN102908674A CN 102908674 A CN102908674 A CN 102908674A CN 201210444957 CN201210444957 CN 201210444957 CN 201210444957 A CN201210444957 A CN 201210444957A CN 102908674 A CN102908674 A CN 102908674A
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Abstract
The invention relates to a preparation method of a stent coating with hemostasis and antibiosis functions. The preparation method comprises the following steps: preparing a medicinal molecular liquid; preparing microspheres containing antiseptic medicaments; respectively dissolving different organic polymers in medicinal molecule-containing liquid and micro-sphere liquid containing antiseptic medicaments; and preparing a composite fibrous material stent coating by utilizing electrostatic spinning. The stent coating prepared by the method contains hemostatic and antibacterial agents, the embedding amount and the embedding rate of the medicament can be improved by regulating the polymer materials, and the hemostatic and antibacterial agents can be controlled to release in phases. The preparation method is simple in process, easy to operate and low in cost, and has wide application prospect in the field of surgical operation.
Description
Technical field:
The present invention relates to a kind of preparation method of multiple bay overlay film, be specifically related to a kind of support overlay film preparation method with hemostatic and antibacterial function.
Background technology:
Overlay film frame refers to apply the support of special film material (politef, terylene, polyester, polyurethane etc.) on support.The function that had both kept support has again the film properties of materials.Along with the deep exploitation of support overlay film, the function vector of support has obtained obvious enhancing, believes by grafting be correlated with chemotherapeutics or radioactive substance, can realize the effect of local sustained release chemotherapy.There is researcher that the paclitaxel overlay film coating biliary tract rack of variable concentrations is acted on the Fel Sus domestica pipe, observed the slow release situation of local organization variation and overlay film medicine, observe Fel Sus domestica mucous membrane epithelium and increase and epithelial metaplasia occur coming off, secrete, wall necrosis and perforation do not appear, medicament slow release is good, thinks to can be used as a kind of new, support developmental pattern safety.
Therefore the focus zone is implanted and is carried the overlay film frame of hemostasis, antibacterials after surgery, both can play the effect of support, simultaneously can local fixed point slow releasing pharmaceutical, prevent the hemorrhage of patient's postoperative tissue, improve the anti-infective effect, reduced material itself and brought the probability of antibacterial into, and for the antibacterial of killing wound site more fast effectively, more targeted more than general intravenous injection antibiotic, utilization rate is higher.In addition, for the wound of having sewed up, with the effectively anti-bacteria regeneration of antibiotic adherence preventing material, and can greatly reduce antibiotic to the infringement of patient body, improve the effect of operation, accelerate the healing rate of wound, be beneficial to patient's post-operative recovery.So in conjunction with the medical present situation of China, be badly in need of a kind ofly can implanting the support overlay film that focal zone has hemostasis, antibacterial functions.
Summary of the invention:
The object of the present invention is to provide a kind of support overlay film preparation method with hemostatic and antibacterial function.
To achieve these goals, the present invention proposes following technical scheme realization:
A kind of support overlay film with hemostatic and antibacterial function, it is characterized in that: the support overlay film is comprised of complex fiber material; Complex fiber material forms mixed solution by organic polymer, drug molecule and the microsphere that contains antibacterials, adopts electrostatic spinning technique to make.
Described organic polymer solution is selected from a kind of in Poly(D,L-lactide-co-glycolide (PLGA), poly(ethylene oxide) (PEO), polyvinyl alcohol (PVA), polylactic acid (PLA), polylactic-co-glycolic acid (PELA), polycaprolactone (PCL).
Described drug molecule is hemostasis agent medicine molecule, and hemorrhage is selected from a kind of in carbazochrome sodium sulfonate, tranexamic acid, Desmopressin, vitamin K1.
Described antibacterials are antibacterial, and antibacterial is selected from a kind of in metronidazole, tinidazole, cefalexin, levofloxacin.
Described microsphere is selected from a kind of in PNIPAM microsphere (PNIPAM), calcium alginate microsphere (SA) and PolybutylcyanoacrylaMicrospheres Microspheres via (PBCA).
Described organic polymer weight average molecular weight is 5-50 ten thousand.
A kind of support overlay film preparation method with hemostatic and antibacterial function comprises the steps:
(1) compounding pharmaceutical molecular solution: drug molecule is dissolved in cosolvent, is mixed with the drug solution that concentration is 5-20%W/V, ultrasonic 10-20 minute, stirring at room 2-5 hour;
(2) preparation comprises the microsphere of antibacterials: the antibacterials molecule is dissolved in cosolvent, and adds the microsphere of mass fraction 1%-5%, by Osmotic balance, preparation comprises the microsphere of antibacterials;
(3) preparation organic polymer solution: different organic polymers is dissolved in respectively (1) (2) contains the medicine molecular solution and comprise in the microspheres solution of antibacterials, be mixed with organic polymer and drug molecule, organic polymer and contain the mixed solution of antibacterials microsphere, wherein the organic macromolecule mass percentage concentration is 20-60%;
(4) preparation complex fiber material: organic polymer and drug molecule mixed solution, the organic polymer of preparing in (3) and the mixed solution that contains the antibacterials microsphere are injected respectively the 5ml syringe, add that diameter is 1-5mm rustless steel medicated pillow, be 10-30KV at voltage, solution flow rate is 1-5ml/h, receiving range is to carry out electrostatic spinning under the condition of 5-25cm, the preparation complex fiber material; Complex fiber material is removed residual solvent, and is preserved in 4 ° of drying baker room temperature vacuum drying 24-48 hour.
Described cosolvent is one or both in DMF, acetone, phosphate buffer, dimethyl sulfoxide, chloroform, oxolane, trifluoroethanol, hexafluoroisopropanol.
Described electrospinning device is many spinning heads electrostatic spinning machine.
Beneficial effect of the present invention: the support overlay film of this patent preparation, comprise simultaneously hemorrhage and antibacterial, by the regulation and control macromolecular material, embedding amount and the embedding rate of medicine have been improved, the control by stages that can realize hemorrhage and antibacterial simultaneously discharges, technique is simple, easy operating and cost low, have wide practical use in surgical field.
The specific embodiment:
Below describe the preferred embodiment of the present invention, but be not to limit the present invention.
Embodiment 1:
Be prepared as follows the support overlay film with hemostatic and antibacterial function:
(1) preparation haemostatic medicament molecular solution: the hemorrhage carbazochrome sodium sulfonate is dissolved in the mixed solution of acetone and dimethyl formamide (DMF) (other 1: 1 of volume), is mixed with the drug solution that concentration is 5% (W/V).After ultrasonic 10 minutes, stirring at room 2 hours.
(2) preparation comprises the microsphere of antibacterials: tinidazole is dissolved in dimethyl formamide (DMF), and adds 1% PNIPAM microsphere (PNIPAM), by Osmotic balance, preparation comprises the microsphere of antibacterials.
(3) preparation macromolecular solution: Poly(D,L-lactide-co-glycolide (PLGA) and polylactic-co-glycolic acid (PELA) (mass ratio 85: 15) are dissolved in above-mentioned hemorrhage solution, Poly(D,L-lactide-co-glycolide (PLGA) is dissolved in the above-mentioned microspheres solution that comprises antibacterials, is mixed with mass percentage concentration and is 50% macromolecule and medicament mixed solution.
(4) preparation complex fiber material: with described organic polymer and hemorrhage, and macromolecule and the mixed solution that comprises the microspheres solution of antibacterial, inject respectively the 5ml syringe, adding No. 5 rustless steel medicated pillows (diameter 3mm), is 20KV at voltage, and solution flow rate is 5ml/h, receiving range is to carry out electrostatic spinning under the condition of 20cm, obtain complex fiber material room temperature vacuum drying 24 hours, remove residual solvent, and preserve in 4 ° of drying baker.
Claims (6)
1. the support overlay film preparation method with hemostatic and antibacterial function, is characterized in that: comprise the steps
(1) compounding pharmaceutical molecular solution: drug molecule is dissolved in cosolvent, is mixed with the drug solution that concentration is 5-20%W/V, ultrasonic 10-20 minute, stirring at room 2-5 hour;
(2) preparation comprises the microsphere of antibacterials: the antibacterials molecule is dissolved in cosolvent, and adds the microsphere of mass fraction 1%-5%, by Osmotic balance, preparation comprises the microsphere of antibacterials;
(3) preparation organic polymer solution: different organic polymers is dissolved in respectively (1) (2) contains the medicine molecular solution and comprise in the microspheres solution of antibacterials, be mixed with organic polymer and drug molecule, organic polymer and contain the mixed solution of antibacterials microsphere, wherein the organic macromolecule mass percentage concentration is 20-60%;
(4) preparation complex fiber material: organic polymer and drug molecule mixed solution, the organic polymer of preparing in (3) and the mixed solution that contains the antibacterials microsphere are injected respectively the 5ml syringe, add that diameter is 1-5mm rustless steel medicated pillow, be 10-30KV at voltage, solution flow rate is 1-5ml/h, receiving range is to carry out electrostatic spinning under the condition of 5-25cm, the preparation complex fiber material; Complex fiber material is removed residual solvent, and is preserved in 4 ° of drying baker room temperature vacuum drying 24-48 hour.
2. a kind of support overlay film preparation method with hemostatic and antibacterial function according to claim 1, it is characterized in that: described drug molecule is hemostasis agent medicine molecule, and hemorrhage is selected from a kind of in carbazochrome sodium sulfonate, tranexamic acid, Desmopressin, vitamin K1.
3. a kind of support overlay film preparation method with hemostatic and antibacterial function according to claim 1, it is characterized in that: described antibacterials are antibacterial, antibacterial is selected from a kind of in metronidazole, tinidazole, cefalexin, levofloxacin.
4. a kind of support overlay film preparation method with hemostatic and antibacterial function according to claim 1 is characterized in that: described microsphere is selected from a kind of in PNIPAM microsphere, calcium alginate microsphere and PolybutylcyanoacrylaMicrospheres Microspheres via.
5. a kind of support overlay film preparation method with hemostatic and antibacterial function according to claim 1 is characterized in that: described organic polymer solution is selected from a kind of in Poly(D,L-lactide-co-glycolide, poly(ethylene oxide), polyvinyl alcohol, polylactic acid, polylactic-co-glycolic acid, polycaprolactone.
6. a kind of support overlay film preparation method with hemostatic and antibacterial function according to claim 1, it is characterized in that: described cosolvent is one or both in DMF, acetone, phosphate buffer, dimethyl sulfoxide, chloroform, oxolane, trifluoroethanol, hexafluoroisopropanol.
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| CN201210444957.6A CN102908674B (en) | 2012-11-09 | 2012-11-09 | A kind of support overlay film preparation method with hemostatic and antibacterial function |
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| CN201210444957.6A CN102908674B (en) | 2012-11-09 | 2012-11-09 | A kind of support overlay film preparation method with hemostatic and antibacterial function |
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| CN102908674A true CN102908674A (en) | 2013-02-06 |
| CN102908674B CN102908674B (en) | 2016-10-05 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599565A (en) * | 2013-11-21 | 2014-02-26 | 无锡中科光远生物材料有限公司 | Antibacterial composition, temperature-sensitive antibacterial film prepared by using antibacterial composition and implant material |
| CN108939136A (en) * | 2018-08-20 | 2018-12-07 | 重庆医科大学附属永川医院 | A kind of dressing and preparation method thereof for nose filling hemostasis |
| CN114053249A (en) * | 2020-08-10 | 2022-02-18 | 山东百多安医疗器械股份有限公司 | Degradable drug-loaded film capable of treating systemic osteoporosis and preparation process thereof |
| CN115337463A (en) * | 2022-04-18 | 2022-11-15 | 东南大学 | Preparation method and application of double-drug-loading microsphere-electrostatic spinning covered stent |
-
2012
- 2012-11-09 CN CN201210444957.6A patent/CN102908674B/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599565A (en) * | 2013-11-21 | 2014-02-26 | 无锡中科光远生物材料有限公司 | Antibacterial composition, temperature-sensitive antibacterial film prepared by using antibacterial composition and implant material |
| CN103599565B (en) * | 2013-11-21 | 2015-04-22 | 无锡中科光远生物材料有限公司 | Antibacterial composition, temperature-sensitive antibacterial film prepared by using antibacterial composition and implant material |
| CN108939136A (en) * | 2018-08-20 | 2018-12-07 | 重庆医科大学附属永川医院 | A kind of dressing and preparation method thereof for nose filling hemostasis |
| CN108939136B (en) * | 2018-08-20 | 2020-12-22 | 重庆医科大学附属永川医院 | Dressing for nasal filling hemostasis and preparation method thereof |
| CN114053249A (en) * | 2020-08-10 | 2022-02-18 | 山东百多安医疗器械股份有限公司 | Degradable drug-loaded film capable of treating systemic osteoporosis and preparation process thereof |
| CN114053249B (en) * | 2020-08-10 | 2023-06-02 | 山东百多安医疗器械股份有限公司 | Degradable medicine carrying film capable of treating systemic osteoporosis and preparation process thereof |
| CN115337463A (en) * | 2022-04-18 | 2022-11-15 | 东南大学 | Preparation method and application of double-drug-loading microsphere-electrostatic spinning covered stent |
| CN115337463B (en) * | 2022-04-18 | 2023-10-13 | 东南大学 | Preparation method and application of double-drug-loaded microsphere-electrostatic spinning tectorial membrane stent |
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| CN102908674B (en) | 2016-10-05 |
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