CN102895629A - Preparation technology and production method for integrated new formulation of cassia twig and oyster decoction - Google Patents
Preparation technology and production method for integrated new formulation of cassia twig and oyster decoction Download PDFInfo
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Abstract
The present invention relates to a preparation technology and a production method for an integrated new formulation of a cassia twig and oyster decoction, wherein the raw materials of active ingredients comprise: 9 parts by weight of cassia twig, 9 parts by weight of Chinese herbaceous peony, 9 parts by weight of ginger, 6 parts by weight of licorice, 12 parts by weight of Chinese-date, 9 parts by weight of fossil bone, and 9 parts by weight of oyster. The production process of the integrated new formulation comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of cassia twig and oyster decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of cassia twig and oyster decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of cassia twig and oyster decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.
Description
Technical field
The present invention relates to a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology, the invention still further relates to a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof.
Background technology
Chinese medicine decocting liquid compound recipe drug effect chemical reaction is too many because of chemical constituent, temporary transient not revealed its Mysterious Veil also, but some mysterious black box drug actions are just ensconced in the Chinese medicine decocting liquid in the Chinese medicinal formulae, can not ask simply Chinese medicine westernization, the modernization of Chinese medicine most and only use monomer and effective site.The Chinese medicine water drug-decocting concentrating liquid could not be given it up! When the Chinese medicinal formulae water decocts, because prescription closes chemical environment complicated in high temperature when frying in shallow oil and the solution, the reaction such as complexation, hydrolysis, oxidation, reduction between intrinsic material may occur in solution, thereby some novel substance that did not originally have in the generation solution, these novel substances produce the drug actions such as potentiation, attenuation or modification to full side.New component forms the research of mechanism, stability and drug effect thereof in the reinforcement Chinese medicinal formulae decocting liquid, to improving Chinese medicine compound and new drug level, progressively dwindle Chinese medicine compound and new Chinese medicine and international gap, very important meaning is arranged, also increased new way and new source for the research and development new Chinese medicine simultaneously.
China's drug control relevant laws and regulations regulation changes dosage form and manages as new drug research.The backwardness of preparation level not only affects the performance of curative effect of medication, and cause the medicine added value low, directly affecting the market competition and industrial economy benefit, is to cause China's medical industry product quantity to occupy prostatitis, the world and the output value only is equivalent to the one of the main reasons of one or two transnational drugmaker.
New drug, novel form development level can embody economy and the technical strength of the medical industry of a country.China's oral formulations accounts for 2/3 of various whole body drug-delivery preparations, and accelerating development and promoting oral sustained-release preparation is the work that current urgent need will be done.
Ramulus Cinnamomi oyster soup prescription derives from " Medical Treasures of the Golden Chamber ".Another name: Ramulus Cinnamomi adds Os Draconis Concha Ostreae soup, Ramulus Cinnamomi Os Draconis Concha Ostreae soup, Os Draconis Concha Ostreae soup, oyster soup.The party's ingredients is Ramulus Cinnamomi, Radix Paeoniae, each 9 gram of Rhizoma Zingiberis Recens, Radix Glycyrrhizae 6 grams, 12 pieces in Fructus Jujubae, Os Draconis, each 9 gram of Concha Ostreae.Usage and dosage: upper seven flavors, with 700 milliliters in water, boil and get 300 milliliters, minute three decoction being taken warmly.Function: regulate yin-yang, He Yingwei, the astringent or styptic treatment for spontaneous sweating seminal fluid of holding concurrently.Adjust the dual power of negative and positive principles, restoring normal coordination between the heart and kidney.Cure mainly: asthenia deficiency of both YIN and YANG, seminal emission, dreaming of sexual intercourse in female patient, spontaneous sweating, the enuresis.Lower abdominal contraction, cold over the glans penis, dizzy (one makes the orbit pain) deals with, and pulse being extremely deficient,hollow and slow is the diarrhea with indigested food exhaustion of blood, and it is moving little tight that arteries and veins gets all onions.The cardiopalmus dreaminess, not cold-resistant heat, pale tongue with thin fur, arteries and veins comes unable person.Ramulus Cinnamomi Os Draconis Concha Ostreae Tangyuan County is that consumption of essence, sexual intercourse in dream are established, because curative effect certainly, liked by the clinicist, the treatment many sections disease that is widely used, such as spontaneous perspiration, night sweat, cardiopalmus, palpitation with fear, renal mass, cough with asthma, be insomnia, dizzy, frequent micturition, the enuresis, turbid urine, have loose bowels, dysphagic, flu, headache, sterile, seminal emission, sexual impotence, postcoital protrusion, hysteria, leukorrhagia, metrorrhagia, alopecia etc.
The side separates:
" Medical Treasures of the Golden Chamber " Zhong Jing says: " husband's patient suffering from frequent seminal emission lower abdominal contraction, cold over the glans penis, dizzy, deal with, pulse being extremely deficient,hollow and slow is diarrhea with indigested foods causing loss of blood and essence, dreaming of sexual intercourse in female patient, Ramulus Cinnamomi add Os Draconis Concha Ostreae soup master it." we have YIN and YANG balance regulating, effect that YANG hyperactivity suppressing is astringent or styptic treatment for spontaneous sweating.
" a Medical Treasures of the Golden Chamber arthralgia due to stagnation of blood spleen fatiguing disease piece of writing " said: " husband's patient suffering from frequent seminal emission, Ramulus Cinnamomi add Os Draconis Concha Ostreae soup master it ".So-called " patient suffering from frequent seminal emission " refers to the people of long-term spermatorrhoea, spermatorrhea history, first time-out, often because moving in the fire of passion, and the institute of can not following one's inclinations is willing to, so that the heart-fire internal combustion, under disturb kidney essense, force seminal fluid leak, pass out semen so usually shown as dream; In the course of time, lose under the kidney unit, lose the astringency inducing function, cause smart closing to cease to be binding admittedly, and finally develop into without dream to walk to let out, become " patient suffering from frequent seminal emission '.So the pathogenesis key of patient suffering from frequent seminal emission is heart kidney yin sun disharmony of QI of the upper and the lower, method for the treatment of is with YIN and YANG balance regulating, and restoring normal coordination between the heart and kidney is main.Guizhi decoction energy and battalion defend, and the spleen and stomach regulating, and YIN and YANG balance regulating add Os Draconis, Concha Ostreae-aspect energy astringing vital QI, and astringency inducing is smart to close, and also plays on the other hand the effect of solid protection heart kidney essense gas
Each is discussed:
1. " Principle and Prohibition for Medical profession ": transfer its battalion to defend bridle late with guizhi decoction; Sering void declines, and adds Os Draconis, puckery its diarrhea with indigested food, exhaustion of blood, the consumption of essence of ending of Concha Ostreae.One side and two grip it and want, sincere sufficient treasured also.
2. " the Medical Treasures of the Golden Chamber opinion is annotated ": Ramulus Cinnamomi, Radix Paeoniae, Gu Yin activates yang; Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubae, and in, the battalion of the part of the body cavity above the diaphragm housing the heart and lungs defends, and makes sun can give birth to the moon, and the master take the Os Draconis of pacifying the kidney mind calming, Concha Ostreae as auxiliary the moon.
3. " collection of prescriptions with notes ": the suffering of Ramulus Cinnamomi, Rhizoma Zingiberis Recens to be moistening it, Radix Glycyrrhizae, Fructus Jujubae sweet mending it, the sour flavor having the property of astringing of Radix Paeoniae, Os Draconis, Concha Ostreae puckery with solid it.
Clinical practice:
1. the enuresis " Medical Treasures of the Golden Chamber the present releases " is drawn " Fructus Citri tangerinae window printed matter that indicates the type form or partial content of books and periodicals ": office of a commanding general in ancient China rally wine well six or three youths, year 18.The enuresis several years, hundred control not effect.More than examine it, lower first deficiency and coldness, it is chilly to urinate, and has under the umbilicus, easily frightened, two foots are chilly.Be to throw Ramulus Cinnamomi to add Os Draconis Concha Ostreae soup, the double 8 flavor balls that take, a few days and decrescence, clothes were fully recovered through half a year.Ramulus Cinnamomi adds Os Draconis Concha Ostreae, and this is for controlling the side of consumption of essence, and old medical this is cured old maid of honour's repeatly little something lost person; Curing the drowning of the old minister of high Technics with the Guo of Tiandong County with this closes; Take not effect person of all medicines, remainingly control the enuresis with this, must imitate repeatedly.
2. seminal emission " classical prescription experiment record ": Zou Pingjun, dying when young has young bad habit, supports for a long time and heals.This winter seminal emission is done again, take Western medicine first two weeks very suitable, a rear week is invalid, more one week clothes anti-play.Essence goes out very dense, and the getting up early rachiagia is dizzy, and I am unequal to painful, in thinking, the weary effect of medicine in west.More than give each 3 money of Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata 2 money, Rhizoma Zingiberis Recens 3 sheets add OS DRACONIS 6 money, left Concha Ostreae 8 money, more than 2 flavors smash, be decocted first 2 hours.After 1 dose, namely ended the very night and losing, though here harmless Zou Jun is from fearing very much.Before sleeping in 3rd, forget to urinate, cause and see 1 time.Namely do not recur later on, former side's plus-minus is repeatedly kicked into 10 doses, and illness is removed, and spirit is good.Meter takes each 3 liang of Ramulus Cinnamomi, Radix Paeoniaes, 6 liang of Os Draconis, 8 liang of Concha Ostreaes.
3. night sweat " classical prescription experiment record ": brother Wu coagulate pavilion, and former times is tasted the illness of suffering from night sweat, and medical Fructus Tritici Levis, Radix Ephedrae, Radix Oryzae Glutinosae are with its antiperspirant only.Turn round and look at only only terminating in the fur of antiperspirant, and do not terminate between the muscle, because being that skin pruritus is unusual, quite feeling and do not relax.From procuratorial organ's book, De Bentang takes it afterwards, perspiration stopped cloud between unconsciously.
4. spontaneous perspiration " Yue Meizhong case ": Lee so-and-so, 40 years old, the male.Suffer from the napex spontaneous perspiration, throughout the day dripping more than, again and again wipe away, quite feel worried, require treatment.It is unable to examine its floating and moderate pulse, spontaneous sweating.Analyze the state, napex are Taiyang channel institute mistakes, and long-term sweating is contrary to upper punch through gas, does not heal lastingly, must cause weakness.Cause is thrown the Ramulus Cinnamomi Os Draconis Concha Ostreae soup of Zhang Zhongjing, and positive sending down the abnormal ascending QI, coordinates battalion and defends, the floating inducing vomiting gas of convergence.Take first 4 doses, from perspiration stopped; Take again 4 doses, to consolidate curative effect.
5. dreaming of sexual intercourse in female patient " Zhejiang Journal of Traditional Chinese Medicine " (1984; 1:46): high so-and-so, woman, 34 years old, peasant.Every and people hands at nightfall, and daybreak begins to go, and 4-5 is mistaken for " fairy fox ", is ashamed beyond words.Just then take exception to, then cardiopalmus is timid for a long time, delays to lose and controls, and state of an illness day is heavy, keeps away and crouches in next-door, still cannot not tangle loosely.Emaciated physique, sleepy weak, deficiency of QI with disinclination to talk, dizziness and blurred vision, waist knee joint epidemic disease is soft, and band is how rare clearly, and body of the tongue is light red, white and thin fur, thready and weak pulse.Be that negative and positive two are lost, disarmony between the heart and kidney belongs to sexual intercourse in dream disease.Plan adds Os Draconis Concha Ostreae soup with Ramulus Cinnamomi: Ramulus Cinnamomi 18g, the Radix Paeoniae Alba, each 20g of Os Draconis, Radix Glycyrrhizae, each 9g of Rhizoma Zingiberis Recens, Concha Ostreae 30g, 7 pieces of Fructus Jujubaes.After 5 doses, all diseases are eliminated, and give GUIPI WAN and consolidate curative effect.Follow up a case by regular visits to not recurrence in 1 year.
We are used for the treatment of hysteria, insomnia, seminal emission or spermatorrhea, infertility, threatened abortion, chronic diarrhea, climacteric syndrome, night sweat, infantile bronchitis etc. and belong to above-mentioned card machine person.There is report to add Radix Angelicae Sinensis, Scorpio treatment hysteria with we; Add Radix Dipsaci, the Cortex Eucommiae, Fructus Lycii treatment neurasthenia; Add Radix Aconiti Lateralis Preparata, Herba Astragali Melilotoidis (Herba Astragali Sinici), Rhizoma Zingiberis treatment infertility; Add Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Pericarpium Citri Reticulatae treatment infantile bronchitis; The diseases such as plus-minus treatment climacteric syndrome, pneumonia, heart disease in children, anejaculation all obtain good result.
Modern pharmacological research:
Modern pharmacological research confirms that we have calm effect, and Os Draconis contain the composition of calcium carbonate, calcium sulfate, can promote blood coagulation, and it is excited to reduce skeletal muscle, reaches effect calm, hemostasis.
The tangible novelty of tool of the present invention and breakthrough are to have found out the key point that Ramulus Cinnamomi oyster soup modern Chinese medicine novel form Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of Ramulus Cinnamomi oyster soup " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, both at home and abroad without identical or similar bibliographical information.Research and development have reached world lead level.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and patent retrieval.Utilize domestic and foreign databases to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains drawing a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano powder body that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. are prepared the nanosphere of different-grain diameter size with the different pharmaceutical carrier, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, immunonanoparticles, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, nanoparticles, millimicro is assisted etc., and then mixing is respectively charged into soft, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) use nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product has the characteristics such as targeting distributes extensively, slow controlled release properties is strong; Have no at home open report in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further: this dosage form preparation technology is the advantage separately of having integrated the traditional Chinese medical science, doctor trained in Western medicine, take the organic conception of theory of Chinese medical science and pay attention to collaborative idea between medicine and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer in treating, pay attention to the mass action that Chinese medicine active substance, effective site and active materials play the treatment disease.Pay attention to the assosting effect that the contained trace element of Chinese medicine plays the treatment disease.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to using nano-carrier multiple techniques development modern Chinese medicine.These will promote the development of China's Chinese Medicine Industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof are provided.
Purpose of the present invention is achieved through the following technical solutions:
A kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: 9 parts of the raw material of this integrated novel form effective ingredient and weight proportion---Ramulus Cinnamomi, 9 parts of Radix Paeoniaes, 9 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae, 12 parts in Fructus Jujubae, 9 parts of Os Draconis, 9 parts of Concha Ostreaes.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
Above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: medicine and carrier are prepared into the pharmaceutical carrier crude drug, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanosuspension, the microcapsule etc., and can as required one or more be mixed.Described protection domain is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not affect its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.Further, above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: the drug carrier material that this novel form is selected, activating agent, help Emulsion, the excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (such as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (such as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.Described excipient substance is not only the said medicine adjuvant in the described scope, and other do not affect its disease of controlling to be also included within the upper interpolation in its basis, and just make the excipient substance of its better efficacy.
Further, above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active materials, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
Again further, above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
A kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, it may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, then adopt supersonic jet mill to the 1-10 micron, get different Chinese medicine micropowder, for subsequent use.
Step 2: get 30%--90% alcohol-water solution that 60% Ramulus Cinnamomi, Radix Paeoniae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae micropowder doubly measures with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility, recovered alcohol, it is for subsequent use to get extract.
Step 3: get 60% Fructus Jujubae, Os Draconis, Concha Ostreae micropowder, adopt the ultrasound wave dispersion extractor to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, to pulverize extraction time be 10-100 minute, and it is for subsequent use to get extract.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt nanon ball-mill to grind 4-16 hour, get the nano powder that particle size distribution is the 50-1000 nanometer, for subsequent use.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate is concentrated, gets extractum or water drug-decocting concentrating liquid with for subsequent use.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt respectively the technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared, obtain the medicine materials such as different medicine monomers, effective site, active materials.
Step 7: adopt different excipient substances by version in 2010 " preparation part of standards standard and " the even method of high pressure breast is adopted respectively in the requirement in 2005 version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " etc. in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, the technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanosuspension, the crude drug such as microcapsule.The crude drug particle diameter is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with the above-mentioned crude drug that mixes adopt full-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out respectively several, bottling, mounted box, sealing, stickup labeling, plays the exterior and interior packings such as code, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
Above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof; wherein: the Chinese medicine of using in described step 1, step 2, the step 3 is pulverized and extracting method; described protection domain is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
Further, above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: the crude drug such as the dissimilar nanoparticle that employing different pharmaceutical adjuvant is prepared in the medicine monomer in the described step 6, active substance, effective site technology of preparing and the described step 7, nano-emulsion.The described protection domain of this claim is not only described technology of preparing and method, as required, be also included within add on its basis or use other better effects if, more economical, upgrade, preparation method more advanced, more environmental protection and technology.
Further, above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: its key point 1 is different utilization nano-carrier multiple techniques different according to the particle diameter of crude drug and the property of medicine, can produce the gentle controlled capability of different targetings.
Again further, above-mentioned a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, wherein: its key point 2 is to develop simultaneously by interior external administration, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be prepared into membrane, transdermal agent is attached to respectively the human body different parts by the energy and blood of human body flowing law, directly absorb by skin.
The outstanding substantive distinguishing features of technical solution of the present invention and significant progressive being mainly reflected in:
The tangible novelty of tool of the present invention and breakthrough are to have found out the key point that Ramulus Cinnamomi oyster soup Chinese and western medicine theory combines, the present invention will in time fill up both at home and abroad and use " nano-carrier multiple techniques " and researching and developing the blank in " the integrated novel form of Ramulus Cinnamomi oyster soup " field with theory of integrated Chinese and western medicine, product has the targeting advantage such as wide that distributes, both at home and abroad without identical or similar bibliographical information.Show substantive progressive and novelty of the present invention by international one-level novelty assessment report and Patent database searching.Utilize domestic and foreign databases to carry out update search, comprehensive domestic and foreign literature is read, analyzing contrast obtains drawing a conclusion: " the integrated novel form of multiple techniques research and development Nano medication " project, its innovative point: 1) adopt the Chinese medicine nano powder body that is rich in trace element, the medicine monomer, effective site, effective part group, Chinese medical concrete, water drug-decocting concentrating liquids etc. are prepared the nanosphere of different-grain diameter size with the different pharmaceutical carrier, nanocapsule, polymer micelle, solid ester matter nanoparticle, magnetic nano particle, immunonanoparticles, nano-emulsion, suspensoid, vesicle, pharmacosomes, microcapsule, nanoparticle, nanoparticles, millimicro is assisted etc., and then mixing is respectively charged into soft, unite simultaneously in the hard capsule and use and be prepared into a kind of integrated novel form or be prepared into the integrated novel form of other types according to above method; 2) use nano-carrier multiple techniques and theory of integrated Chinese and western medicine research and development " the integrated novel form of Nano medication ", product has the characteristics such as targeting distributes extensively, slow controlled release properties is strong; Have no at home open report in the document, these project complex art characteristics have certain novelty and novelty.Science and technology is looked into new numbering: 200921c0704948.
Further, this dosage form preparation technology and production method thereof are to have integrated the advantage separately of the traditional Chinese medical science, doctor trained in Western medicine, take the organic conception of theory of Chinese medical science and pay attention to collaborative idea between medicine and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as the overall strategy tactical thinking, in conjunction with modern western pharmacology, pharmacokinetics, toxicology, pharmaceutics scheduling theory, pay attention to effectiveness and the therapeutic effect of certified Chinese medicine one matter monomer in treating, pay attention to the assosting effect that Chinese medicine active substance, effective site and active materials play the treatment disease.Pay attention to the assosting effect that the contained trace element of Chinese medicine plays the treatment disease.The effective ingredient of the used Chinese medicine of this Chinese medicine compound is clear and definite, and medicine effect has obtained admitting of modern medicine.Pay attention to the different nano-carrier dosage form technologies of preparing of Chinese medicine and unite use.To adopt Chinese medicine crude drug nano-powder, monomer, effective site, effective part group, traditional Chinese drug inspissation extractum, water drug-decocting concentrating liquid, nano-medicament carrier etc. to unite use on the compatibility.These various Chinese traditional powder particle diameter major parts of filling a prescription are the granule of 50～1000 nanometers.Adopting different nano-medicament carriers to be prepared into nanoparticle, nanosphere, nanocapsule, solid ester matter nanoparticle, nano-emulsion, vesicle, pharmacosomes, microcapsule, nanoparticle, nanoparticles, millimicro assists etc.Its particle size distribution is in 10 nanometers---between-10 microns.Then theoretical according to difference, the difference of slow controlled release time and the traditional Chinese medical science monarch of pharmacology, targeting, reasonable compatibility mixes, and is respectively charged among hard capsule and the soft capsule.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into respectively the targeted systems such as RE targeted system, stomach mucosa absorption system, intestinal absorption system, colon absorption system.Compare Chinese medicine and medicine monomer, the target-oriented drug of the overall coordination therapeutical effect of this Chinese medicine compound novel form, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.Multichip carrier and multiple medicines thing monomer etc. are united use, have broken through the traditional monarch compatibility theory of the traditional Chinese medical science, for the modern Chinese medicine development provides a practical effective novel form compatibility program.To have substantial technological innovation to break through.
Purpose of the present invention, advantage and disadvantage will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
A kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof, its special feature is: the raw material composition of making effective ingredient is by weight ratio---9 parts of Ramulus Cinnamomi, 9 parts of Radix Paeoniaes, 9 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae, 12 parts in Fructus Jujubae, 9 parts of Os Draconis, 9 parts of Concha Ostreaes.
Further, play the synergy of standing like the legs of a tripod on the integrated new drug formulation compatibility of Ramulus Cinnamomi oyster soup of the present invention: 1, prepare nanometer, micro-powder with the prepared slices of Chinese crude drugs, the bioavailability after strengthening Ramulus Cinnamomi oyster soup curative effect and significantly improve prepared slices of Chinese crude drugs cell wall breaking with this; 2, with Chinese medicine extract and select suitable pharmaceutical carrier, prepare different Chemistry for Chinese Traditional Medicine monomers, effective ingredient, effective site etc., confirm and strengthen pharmacology, the efficacy of the chemical substance of Ramulus Cinnamomi oyster soup with this; 3, prepare Chinese medical concrete, water drug-decocting concentrating liquid with the prepared slices of Chinese crude drugs, the temporary transient unpredictable drug effect of bringing with this reaction such as complexation, hydrolysis, oxidation, reduction of strengthening Ramulus Cinnamomi oyster soup Chinese medicine compound uniqueness also keeps and has strengthened traditional Chinese medical science organic conception, monarch concept.Above three aspects: associating compatibility uses, different according to Nano medication particle diameter and character, can reach many targeting, many collaborative, slow controlled release texts, and play useful effect to strengthening the medicine pharmacologically active, effective ingredient pharmacological action effect is significantly higher than conventional formulation.
Production method of the present invention may further comprise the steps:
At first, get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, then adopt supersonic jet mill to the 1-10 micron, get different Chinese medicine micropowder, for subsequent use.Get 30%--90% alcohol-water solution that 60% Ramulus Cinnamomi, Radix Paeoniae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae micropowder doubly measures with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times is extracted water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility, recovered alcohol, and it is for subsequent use to get extract.Get 60% Fructus Jujubae, Os Draconis, Concha Ostreae micropowder, adopt the ultrasound wave dispersion extractor to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, and it is for subsequent use to get extract.With above-mentioned gained Chinese medicine extract, adopt nanon ball-mill to grind 4-16 hour, get the nano powder that particle size distribution is 50 nanometers-1000 nanometer, for subsequent use.Get each Chinese medicine micropowder of 40% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate concentrates, and gets extractum or water drug-decocting concentrating liquid with for subsequent use.With above-mentioned gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt respectively the technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared, obtain the medicine materials such as different medicine monomers, effective site, active materials.Adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " the even method of high pressure breast is adopted respectively in the requirement in 2005 version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " etc. in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, the technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanosuspension, the crude drug such as microcapsule.The crude drug particle size distribution of preparing is between 10 nanometers-10 micron." preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as above-mentioned gained Chinese medical concrete or water drug-decocting concentrating liquid and above-mentioned gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.In GMP10000 level toilet, with the above-mentioned crude drug that mixes adopt full-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can make by the related preparations standard criterion the above-mentioned end product of other type.The end product of making is carried out respectively several, bottling, mounted box, sealing, stickup labeling, plays the exterior and interior packings such as code, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
" embodiment one "
Press the following crude drug of preceding method preparation: extractum, nanoparticle, microcapsule, nanoparticle.
Its raw material of making effective ingredient forms---9 parts of Ramulus Cinnamomi, 9 parts of Radix Paeoniaes, 9 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae, 12 parts in Fructus Jujubae, 9 parts of Os Draconis, 9 parts of Concha Ostreaes.
Its manufacture process is as follows: in GMP10000 level toilet with extractum, nanoparticle, microcapsule, nanoparticle in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia hard capsule standard in 2010, do not add adjuvant, antiseptic, adopt full-automatic capsule filling machine fill hard capsule, make hard capsule.Carry out again several, bottle, seal, paste labeling, play the exterior and interior packings such as code, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment two "
Press the following crude drug of preceding method preparation: water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion.
Its raw material of making effective ingredient forms---9 parts of Ramulus Cinnamomi, 9 parts of Radix Paeoniaes, 9 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae, 12 parts in Fructus Jujubae, 9 parts of Os Draconis, 9 parts of Concha Ostreaes.
Its manufacture process is as follows: in GMP10000 level toilet with water drug-decocting concentrating liquid, nanometer liposome, nano-emulsion, microemulsion in 4: 2: 2: after 2 ratios are mixed, adopt a version " preparation part of Chinese pharmacopoeia soft capsule standard in 2010, do not add adjuvant, antiseptic, adopt full-automatic soft capsule filling machine packing soft capsule, make soft capsule.Carry out again several, bottle, seal, paste labeling, play the exterior and interior packings such as code, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.
" embodiment three "
Press the following crude drug of preceding method preparation: extractum, nanoparticle, nano-emulsion.
Its raw material of making effective ingredient forms---9 parts of Ramulus Cinnamomi, 9 parts of Radix Paeoniaes, 9 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae, 12 parts in Fructus Jujubae, 9 parts of Os Draconis, 9 parts of Concha Ostreaes.
Its manufacture process is as follows: after in the GMP10000 level toilet extractum, nanoparticle, nano-emulsion being mixed in 4: 3: 3 ratios, " a preparation part of Chinese pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, makes membrane to adopt version in 2010.Carry out again mounted box, sealing, stickup labeling, play the exterior and interior packings such as code, vanning.Unify instantaneously sterilising by production batch at last, and open the sterilization report.Every membrane area size is the 2-40 square centimeter, and every medicine film pasted 12-72 hour, pasted the medicine position: the positions such as neck, chest, back part, abdominal part, shank, foot bottom, Ashi point.
Can find out by above-mentioned text description: the tangible novelty of tool of the present invention and breakthrough are to have found out the key point that Ramulus Cinnamomi oyster soup Chinese medicine compound Chinese and western medicine theory combines, and the compound compatibility of modern Chinese medicine and technology of preparing can change the pharmacokinetic parameter of medicine monomer, effective ingredient or effective part group.This has proved the scientific meaning of Chinese medicine compound compatibility from the pharmacokinetics level." very just be harmonious, negative and positive intercommunication, coordinating water and fire, precise and tiny circle melt, and greatness lies in the capacity " is that the precise and tiny circle of the integrated novel form of this medicine melts Integration Theory basis and guiding theory.Among the present invention: monomer, effective site, nanoparticle and carrier etc. be strange, be tiny, be cloudy.Traditional Chinese medical science organic conception, Chinese medical concrete, water drug-decocting concentrating liquid etc. be just, be grand, be the sun.Very just be harmonious then negative and positive intercommunication, the negative and positive intercommunication is then coordinating water and fire, is the optimum balance attitude.Doctor trained in Western medicine research is precise and tiny, and theory of Chinese medical science is that circle melts, and both very just are harmonious, and have just really embodied the organic conception of the combination of Chinese and Western medicine, and " close " is that " integration " is for holding.The tidemark that greatness lies in the capacity, the coordinating water and fire the present invention of being only asked most.This integrated novel form is by the reasonable compatibility of Chinese medicine monomer, effective site, active substance, Chinese medicine active materials, extractum, water drug-decocting concentrating liquid, prepared slices of Chinese crude drugs nano-particle etc., can produce soft, hard capsule or the dosage forms such as nanometer membrane, transdermal agent.Can develop simultaneously, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law by interior external administration.Can also do film former to nano traditional Chinese medicine, transdermal agent is attached to the human body different parts, can directly absorb by skin.
See that further the various Chinese medicine particle diameter major parts that the present invention prepares are the granule of 50～1000 nanometers.Adopt different nano-medicament carriers and technology can be prepared into nanoparticle, nanosphere, solid ester plastid, nano-emulsion, pharmacosomes, microgranule, nanoparticles, little assist etc.Its particle size distribution is in 10 nanometers---between-10 microns.Then theoretical according to difference, the difference of slow controlled release time and the traditional Chinese medical science monarch of medicine pharmacology, targeting, reasonable compatibility mixes, and can be respectively charged among hard capsule and the soft capsule.Difference according to the dissolving of capsule material, disintegrate, jitter time can be prepared into respectively the targeted systems such as RE targeted system, stomach mucosa absorption system, intestinal absorption system, colon absorption system.Compare Chinese medicine and medicine monomer or Western medicine, the overall coordination therapeutical effect of this integrated novel form and target-oriented drug, slow controlled capability are stronger, and curative effect is more outstanding, and toxic and side effects still less.For Ramulus Cinnamomi oyster soup modern Chinese medicine preparation and production have proposed a practical effective novel form compatibility program.To have substantial innovation and technological break-through.
Resemble the such classics side of Ramulus Cinnamomi oyster soup and be the imbody of the theoretical marrow of differentiation of tcm, and the party has a wide range of applications in the different field of tcm clinical practice, go through bimillennium and do not wane.Therefore, its full side is carried out further developmental research important in inhibiting.This just need us Emancipate the mind and seek truth from facts from Chinese medical theory, strengthen the research and development dynamics of traditional Chinese medical science ancient prescription, make these ancient prescriptions obtain more adequately and reasonably using.
Claims (10)
1. a Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof is characterized in that: 9 parts of the raw material of this novel form effective ingredient and weight proportion---Ramulus Cinnamomi, 9 parts of Radix Paeoniaes, 9 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae, 12 parts in Fructus Jujubae, 9 parts of Os Draconis, 9 parts of Concha Ostreaes.
Wherein, described each Chinese medicine is rich in one or more trace element such as organic zinc, selenium.
2. a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology according to claim 1 and production method thereof, it is characterized in that: medicine and carrier are prepared into the pharmaceutical carrier crude drug, crude drug can be one or more combinations in nanoparticle, nanoparticle, micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanosuspension, the microcapsule etc., and can as required one or more be mixed.The described protection domain of this claim is not only the said medicine support material medicine in the described scope, is also included within to prepare on its basis or add the curative effect that other do not affect its disease of controlling, and just makes the pharmaceutical carrier crude drug of its better efficacy.
3. according to claim 1,2 described a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology and production methods thereof, it is characterized in that: the drug carrier material that this novel form is selected, activating agent, help Emulsion, the excipient substances such as dispersant are gelatin, albumin, starch and derivant thereof, alginate, beta-schardinger dextrin-, protein, chitosan and derivant thereof, lactose, hydroxypropyl emthylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, polylactic acid, cyanoacrylate, the semisolid poe, triglyceride is (such as three stearic acid, three Palmic acids, three lauric acids, in three oleic acid etc., the glyceride of long-chain fatty acid), glyceride (such as glyceryl monostearate, contains list, two, the synthetic glyceride of triglyceride), cholesterol, Polyethylene Glycol, microcrystalline wax, the whale ester type waxes, erythrocyte, Montmorillonitum, in the tea powder etc. one or more.The described protection domain of this claim is not only the said medicine adjuvant in the described scope, and other do not affect its disease of controlling to be also included within the upper interpolation in its basis, and just make the excipient substance of its better efficacy.
4. according to claim 1 and 2 or the described a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology of 3 any one and production method thereof, it is characterized in that: said integrated novel form adopts medicament nano powder body, micro-powder, medicine monomer, effective ingredient, effective site, active materials, Chinese medical concrete, water drug-decocting concentrating liquid to unite use with different excipient substance, pharmaceutical carrier according to indexs such as the pharmacology of traditional Chinese medical science global theory, compatibility theory and medicine, drug effect, medicine generation, toxicitys.And can mix its one or more according to the preparation needs.
5. according to claim 1 and 2 or the described a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology of 3 or 4 any one and production method thereof, it is characterized in that: the integrated novel form end product that finally can form is: tablet, powder, suppository, stick, granule, soft capsule, hard capsule, effervescent, drop pill, aerosol, unguentum, oral solution, slow releasing tablet, controlled release tablet.
6. a Ramulus Cinnamomi oyster soup dosage form preparation technology and production method thereof is characterized in that may further comprise the steps:
Step 1: get each prepared slices of Chinese crude drugs pretreatment, insert pulverizer after the weighing and be crushed to the 80-200 order, then adopt supersonic jet mill to the 1-10 micron, get different Chinese medicine micropowder, for subsequent use.
Step 2: get 30%--90% alcohol-water solution that 60% Ramulus Cinnamomi, Radix Paeoniae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae micropowder doubly measures with 6-12 and mix and soaked 1-2 days, reflux, extract, 3 times, extract water solublity, pure dissolubility, three kinds of active drug compositions of ester dissolubility, recovered alcohol, it is for subsequent use to get extract.
Step 3: get 60% Fructus Jujubae, Os Draconis, Concha Ostreae micropowder, adopt the ultrasound wave dispersion extractor to disperse respectively to extract, ultrasonic power is: 800W-3000W, supersonic frequency: 28KHz--120KHz, extraction time are 10-100 minute, and it is for subsequent use to get extract.
Step 4: with step 2, step 3 gained Chinese medicine extract, adopt nanon ball-mill to grind 4-16 hour, get the nano powder that particle size distribution is the 50-1000 nanometer, for subsequent use.
Step 5: get each Chinese medicine micropowder of 40%, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges and filters, and filtrate is concentrated, gets extractum or water drug-decocting concentrating liquid with for subsequent use.
Step 6: with step 2, step 3, step 4 gained Chinese medicine extract, nano powder as required with and the different property of medicine, pharmacological actions, can adopt respectively the technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to be prepared, obtain the medicine materials such as different medicine monomers, effective site, active materials.
Step 7: adopt different excipient substances and carrier by version in 2010 " related preparations part of standards standard and " the even method of high pressure breast is adopted respectively in the requirement in 2005 version Chinese pharmacopoeia appendix XIXE " microcapsule; microsphere; with the Liposomal formulation guideline " etc. in the Chinese pharmacopoeia above-mentioned gained medicine material, inclusion technique, solid state technology, polishing, solvent-fusion method, squeezing and pressing method, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, the technology such as freeze-drying are prepared into nanoparticle, nanoparticle, the micron liposome, nanometer liposome, solid lipid nanoparticle, nanometer polymer micelle, pharmacosomes, nano-emulsion, lipid microsphere, microcapsule, microemulsion, lipid liquid, nanometer film, nanosuspension, the crude drug such as microcapsule.The crude drug particle diameter is between 10 nanometers-10 micron.
Step 8: " preparation part of standards code requirement in the Chinese pharmacopoeia was got in the crude drug such as step 5 gained Chinese medical concrete or water drug-decocting concentrating liquid and step 7 gained nanoparticle, liposome, nano-emulsion, microcapsule one or more and is mixed by formula proportion by version in 2010.
Step 9: in GMP10000 level toilet, with the above-mentioned crude drug that mixes adopt full-automatic capsule filling machine respectively fill become hard capsule and soft capsule.Also can by version in 2010 " Chinese pharmacopoeia related preparations standard criterion is made the above-mentioned end product of other type.
Step 10: the end product of making is carried out respectively several, bottling, mounted box, sealing, stickup labeling, plays the exterior and interior packings such as code, vanning.Packaged product is transported to the appointed place by production batch and unifies instantaneously sterilising, and opens the sterilization report.
7. a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology according to claim 6 and production method thereof; it is characterized in that: the pulverizing of using in described step 1, step 2, the step 3 and extracting method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if, more economical, renewal, breaking method more advanced, more environmental protection, extracting method and technology.
8. a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology according to claim 7 and production method thereof; it is characterized in that: the medicine monomer in the described step 6; active substance; the dissimilar nanoparticle that adopts the different pharmaceutical adjuvant to be prepared in effective site technology of preparing and the described step 7; the crude drug such as nano-emulsion; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within and add on its basis or use other better effects if; more economical; upgrade; more advanced; the more preparation method of environmental protection and technology.
9. a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology according to claim 8 and production method thereof, it is characterized in that: its key point 1 is different utilization nano-carrier multiple techniques different according to the particle diameter of crude drug and the property of medicine, can produce the gentle controlled capability of different targetings.
10. a kind of Ramulus Cinnamomi oyster soup dosage form preparation technology according to claim 9 and production method thereof is characterized in that: its key point 2 be can in external administration develop simultaneously, can take four time periods respectively by midnight-noon and ebb-flow doctrine, energy and blood of human body flowing law.Also can be prepared into membrane, transdermal agent is attached to respectively the human body different parts by the energy and blood of human body flowing law, directly absorb by skin.
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