CN102885789A - Preparation method of compound preparation for treating high blood pressure - Google Patents

Abstract

The invention relates to a double-layer tablet for treating high blood pressure and a preparation method of the double-layer tablet. The double-layer tablet comprises a first layer which contains angiotensin II receptor antagonist telmisartan and complex solubilizer, and a second layer which contains diuretic hydrochlorothiazide and disintegrant. The invention also discloses the preparation method of the double-layer tablet.

Description

A kind of preparation method for the treatment of hypertensive compound preparation

Technical field:

The invention belongs to field of pharmaceutical preparations, be specifically related to a kind of layer tablets preparation that contains angiotensin ii receptor antagonist telmisartan and diuretic hydrochlorothiazide.The present invention also provides the method for preparing described bilayer tablet.

Technical background:

Telmisartan is a kind of novel angiotensin-ii receptor inhibitor, and it is disclosed in EP-A-50231 first.The chemical name of telmisartan is 4 '-[2-n-pro-pyl-4-methyl-6-(1-tolimidazole-2-yl)-benzimidazole-1-ylmethyl]-xenyl-2-carboxylic acid, and its structural formula is as follows:

Telmisartan is by former the grinding of German Boehringer Ingelheim drugmaker, at first ratifies the listing in the U.S. in November, 1998, then in Germany, and Philippine, Australia, Belgium, Britain, country's listings such as China.Compare with other sartans, telmisartan has outstanding long-acting advantage.Telmisartan and AT I receptor subtype have high-affinity, long-acting inhibition angiotensin-ii receptor, and depression effect continues 24h, still can measure at 48h.The interior antihypertensive effect of 3h is obvious gradually behind the first dose of telmisartan.Around after the treatment beginning, can obtain the maximum reducing effect, but and long term maintenance.Effect of Telmisartan such as unexpected interruption, blood pressure returns to level before the treatment gradually after a couple of days, and having a rebound property hypertension not.

Hydrochlorothiazide has another name called Hydrochlorothiazide, two hydrogen aquil, and its chemistry is by name: 6-chloro-3, and 4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1, the 1-dioxide, its structure is as follows:

Hydrochlorothiazide can suppress the Distal convoluted tubule near-end to the heavily absorption of sodium ion and chloride ion, making the kidney increasing to the Excretion of sodium chloride, thereby produce diuresis, is a kind of middle effect diuretic, hydrochlorothiazide has hypotensive activity, and normal and other antihypertensive drugs couplings are to control blood pressure clinically.But the poorly water-soluble of hydrochlorothiazide is unfavorable for absorbing, and therefore developing new dosage form promotes its absorption, thereby improves bioavailability.

CN1615123A discloses the layer tablets that contains telmisartan and hydrochlorothiazide, and wherein telmisartan is namely released partly and supplied with free acid form, it is characterized in that dissolubility extreme difference in the aqueous systems of telmisartan in gastrointestinal physiology pH value scope.Disclosed such as WO043370, the crystallization telmisartan exists with two kinds of crystal formations, under the impact of heat and humidity, and the irreversible polymorphic A that is converted into higher melt of low-melting polymorph b.

Goal of the invention:

The drug combination of telmisartan and hydrochlorothiazide demonstrates obvious synergistic therapeutic action in treatment hypertension, in order to increase patient's compliance, therefore be fit to very much be developed as compound preparation.

Therefore, purpose of the present invention is exactly to improve a kind of compound preparation that comprises telmisartan and hydrochlorothiazide, and described compound preparation demonstrates required quick dissolving, discharges and the feature of enough stability fast.

Usually, the compound preparation that needs rapid release to discharge all is that active ingredient is prepared into mixture of powders, then adds necessary adjuvant, is prepared into dosage form, and it has generally kept the basis of corresponding single medicine dosage form, in simple the second ingredient that adds.But telmisartan and hydrochlorothiazide Compound preparation adopt this method and infeasible, because hydrochlorothiazide and alkali substance reaction salify (such as the conventional ingredient meglumine in the Telmisartan formulations), therefore can greatly reduce the dissolution rate of medicine, reduce bioavailability.

We adopt bilayer tablet to solve this problem, and this layer tablets comprises the ground floor that contains the telmisartan composition and contains the second layer of hydrochlorothiazide composition.

Summary of the invention:

The invention provides a kind of bilayer tablet that contains telmisartan and hydrochlorothiazide, this double-layer tablet can promote the dissolving of medicine, accelerates the disintegration rate of medicine, thereby improves the bioavailability of medicine.

The invention provides a kind of method of producing the double-layer tablet preparation, comprise step:

1. the preparation of the first lamella:

A. the aqueous solution for preparing telmisartan, alkaline reagent, cosolvent;

B. spray drying aqueous solution described above obtains spray-dired shot-like particle;

C. mix the diluent of described spray-dired shot-like particle and aqueous solution, obtain premix;

D. mix described premix and lubricant, obtain the final mixture of the first lamella.

2. the preparation of the second lamella:

A. with hydrochlorothiazide and disintegrating tablet substrate mixing;

B. said mixture is made again the final mixture of the second lamella with mix lubricant.

3. the preparation of double-layer tablet:

A. with above-mentioned first and second layer compositions as for tablet machine;

B. compress the first lamella mixture, form the first lamella;

C. the second lamella mixture is placed tablet machine, compression two parts lamella forms the biplate layer.

The present invention is described in further detail below in conjunction with embodiment, and embodiment provides as the purpose of illustration, do not consist of limitation of the scope of the invention.

The specific embodiment:

Preparation method:

1. the preparation of the final mixture of the first lamella.

Under 20 ℃ of conditions, 200.0kg pure water, 3.0kg sodium hydroxide, 6.0kg sodium salicylate, 45.0kg telmisartan, 14.0kg 30 POVIDONE K 30 BP/USP, 13.5kg meglumine are added in the rustless steel container, be made into pale yellow solution, stand-by.

Mentioned solution is sprayed in the suitable spray dryer, and spray drying obtains white to linen fine grained, obtains the final mixture of the first above-mentioned lamella after sieving.

2. the final mixture of the second lamella.

With 9.0kg70 ℃ pure water, the starch of 6.0kg, the lactose monohydrate of 112.0kg, 12.5kg hydrochlorothiazide, 64.0kg microcrystalline Cellulose sodium 0.330kg red iron oxide are mixed to even phase, get the final mixture of the second lamella.

3. the preparation of double-layer tablet.

Use suitable tablet machine, the final mixture of 240kg the first lamella and the final mixture of 200kg the second lamella are pressed into double-layer tablet, the theoretical weight of ground floor is 240mg, and the theoretical weight of the second layer is 200mg.

Claims (4)

1. compound double-layer tablet that contains telmisartan and two kinds of active component of hydrochlorothiazide, it is characterized in that hydrochlorothiazide mixes with pharmaceutically acceptable disintegrating agent in the lamella, telmisartan mixes with pharmaceutically acceptable cosolvent, alkaline reagent in another lamella.

2. compound double-layer tablet according to claim 1 is characterized in that the disintegrating agent that mixes with hydrochlorothiazide is selected from one or more in sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, the dried starch.

3. compound double-layer tablet according to claim 1 is characterized in that the cosolvent that mixes with telmisartan is selected from one or more in sodium benzoate, sodium salicylate, the para-amino benzoic acid.

4. compound double-layer tablet according to claim 1, its preparation method comprises:

The preparation of I the first lamella:

A. the aqueous solution for preparing telmisartan, alkaline reagent, cosolvent;

B. spray drying aqueous solution described above obtains spray-dired shot-like particle;

C. mix the diluent of described spray-dired shot-like particle and aqueous solution, obtain premix;

D. mix described premix and lubricant, obtain the final mixture of the first lamella.

The preparation of II the second lamella:

A. with hydrochlorothiazide and disintegrating tablet substrate mixing;

B. said mixture is made again the final mixture of the second lamella with mix lubricant.

The preparation of III double-layer tablet:

A. with above-mentioned first and second layer compositions as for tablet machine;

B. compress the first lamella mixture, form the first lamella;

C. the second lamella mixture is placed tablet machine, compression two parts lamella forms the biplate layer.