CN102872763A - Reaction kettle for solid phase synthesis - Google Patents
Reaction kettle for solid phase synthesis Download PDFInfo
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- CN102872763A CN102872763A CN2012103579591A CN201210357959A CN102872763A CN 102872763 A CN102872763 A CN 102872763A CN 2012103579591 A CN2012103579591 A CN 2012103579591A CN 201210357959 A CN201210357959 A CN 201210357959A CN 102872763 A CN102872763 A CN 102872763A
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- solid phase
- phase synthesis
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Abstract
A reaction kettle for solid phase synthesis is used for realizing all reactions, including stirring and cleaning small-scale reaction kettle container, during solid phase synthesis. The reaction kettle comprises a kettle body and a demountable sealing head with a cleaning tool, which are fixed together; the kettle body further comprises a pyriform transparent reaction mechanism or a reaction mechanism with a window, a sieve plate at the lower end of the kettle body, and a communicating pipe which integrates liquid feeding, liquid drainage and stirring; and a cleaning spray header is arranged on the demountable sealing head and is communicated with an external pipeline which is a cleaning and ventilation pipeline. With the kettle body, during the solid phase synthesis in the reaction kettle, stirring reaction is realized, the synthesis efficiency is improved, the reaction reagent dose is reduced, the reaction time is shortened, and the solid phase synthesis cost is greatly reduced.
Description
Technical field
The invention belongs to the employed reactor structure innovation of chemical reaction type technical field, be specifically related to a kind of for realizing that synthetic each the step reaction of solid phase comprises stirring, the small-scale reactor vessel that clean.
Background technology
At present, domestic and international existing solid phase synthesis still all adopts the unidirectional chromatography of pillar formula, and synthetic reaction is all from top to bottom reacted as main by reaction column take reagent.This reactor expends a large amount of synthetic agents when synthetic, has increased synthetic cost.And the various process that solid phase is synthetic changes the post internal pressure, greatly affects follow-up combination reaction, thereby affects combined coefficient, produces the defective that is difficult for overcoming.
Summary of the invention
The purpose of this invention is to provide a kind of rational in infrastructure, synthetic reactor of using of the simple novel solid phase of technique.It can reduce synthetic agent consumption, Reaction time shorten.
The technical solution adopted in the present invention is as follows:
A kind of solid phase synthesis still, comprise kettle and with the detachable end socket of cleaning means, the two links together, described detachable end socket is with specific gas-liquid spray structure, described kettle further comprises the transparent or band form reaction mechanism of a pyriform, comprise that the kettle lower end arranges a sieve plate, autoclave body bottom connects the pipeline of collection feed liquor, discharge opeing, stirring integrated formula.
Described pyriform reaction mechanism is glass material or band form corrosion-resistant material, the reaction kettle body design that resembles a pear in shape, and two is thin up and down, and is slightly middle.
Described connecting pipe is vertically connected at the bottom of pyriform reaction mechanism.
Described sieve plate is core, pottery or the corrosion-resistant material of other loose structure, can stop specific solid-phase media to pass through.
Described sieve plate is fixed on the lower end of pyriform reaction kettle body, is positioned at the pipeline top of its bottom.
Described detachable end socket is positioned at the top of reaction kettle body.
Described detachable end socket is with spray head and connected pipeline.
Described spray head outlet is lower than detachable end socket, can thoroughly clean kettle.
Described spray head closely is connected with the pipeline that stretches into detachable end socket lower end.
The nozzle of described spray head is over against sieve plate.
Superiority of the present invention and beneficial effect are: changed inhomogeneous because of filler filling, the inner caking of pillar reactor, the bad phenomenon such as pressure imbalance in the course of reaction is so that the carrier reaction is more even, abundant; Adopt the pneumatic stirring mode, can not destroy the structure of solid phase carrier, so that course of reaction has higher uniformity; The cleaning process of dry reaction liquid so that solvent and product effective separation reduce the consumption of reaction reagent, thereby reduces synthetic cost.
Figure of description
Accompanying drawing is the structural representation of a kind of solid phase synthesis still of the present invention.
Specific embodiments
See also shown in the accompanying drawing, the invention provides that a kind of solid phase is synthetic use reactor, comprise pipeline 1, detachable end socket 2, cleaning spray head 3, kettle 4, sieve plate 5 and pipeline 6.
Described pipeline 1 stretches into detachable end socket 2 belows, transport cleaning liquid and gas.
Described detachable end socket 2 is connected with kettle 4, and convenience picks and places with kettle 4 interior solid phase carriers.
Described cleaning spray head 3 is connected with pipeline 1, is used for cleaning kettle 4, and it is large to wash away area, and impulsive force is strong, and cleaning efficiency is high.
The material of described kettle 4 is decided the corrosion condition of material according to synthetic agent, the optional glass of material or with the corrosion-resistant material of form.
Described sieve plate 5 is fixed on the lower end of kettle 4, stays certain space with between the bottom.
Described pipeline 6 is communicated with the bottom of kettle 4, for delivery of reagent, gas.
Solid phase of the present invention is synthetic uses reactor, carries liquid to enter kettle 4 in described pipeline 6, constantly carries afterwards gas to enter kettle 4 in described pipeline 6, and is discharged by pipeline 1, makes liquid enter the sieve plate top and fully reacts with solid phase carrier.Reacted waste liquid is carried gas by pipeline 1, utilizes air pressure that waste liquid is discharged by pipeline 6.Transport cleaning liquid enters spray head 3 in described pipeline 1, and kettle 4 is thoroughly cleaned.
The above only is optimum implementation of the present invention, is not the present invention is done any pro forma restriction.Any those of ordinary skill in the art are not breaking away from the technical solution of the present invention scope situation, utilize the method content of above-mentioned prompting that technical solution of the present invention is made many possible changes and modification, all belong to the scope of claims protection.
Claims (10)
1. solid phase synthesis still, comprise kettle and with the detachable end socket of cleaning means, the two links together, described detachable end socket is with specific gas-liquid spray structure, described kettle further comprises the transparent or band form reaction mechanism of a pyriform, comprise that the kettle lower end arranges a sieve plate, comprise that autoclave body bottom connects a pipeline.
2. solid phase synthesis still according to claim 1 is characterized in that described pyriform reactor is glass material or the corrosion-resistant material of band form, the reaction kettle body design that resembles a pear in shape, and two is thin up and down, and is slightly middle.
3. solid phase synthesis still according to claim 1 is characterized in that described pipeline is connected in the bottom of pyriform reaction kettle body.
4. solid phase synthesis still according to claim 1 is characterized in that described sieve plate is core, pottery or the corrosion-resistant material of other loose structure.
5. solid phase synthesis still according to claim 1 is characterized in that described sieve plate is fixed on the lower end of pyriform reaction kettle body, is positioned at the pipeline top of its bottom.
6. solid phase synthesis still according to claim 1 is characterized in that described detachable end socket is positioned at the top of reaction kettle body.
7. solid phase synthesis still according to claim 1 is characterized in that described detachable end socket is with spray head and connected pipeline.
8. solid phase synthesis still according to claim 7 is characterized in that described spray head outlet is lower than detachable end socket.
9. solid phase synthesis still according to claim 7 is characterized in that described spray head closely is connected with the pipeline that stretches into detachable end socket lower end.
10. solid phase synthesis still according to claim 7 is characterized in that the nozzle of described spray head is over against sieve plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103579591A CN102872763A (en) | 2012-09-21 | 2012-09-21 | Reaction kettle for solid phase synthesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103579591A CN102872763A (en) | 2012-09-21 | 2012-09-21 | Reaction kettle for solid phase synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102872763A true CN102872763A (en) | 2013-01-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012103579591A Pending CN102872763A (en) | 2012-09-21 | 2012-09-21 | Reaction kettle for solid phase synthesis |
Country Status (1)
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| CN (1) | CN102872763A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10325912A1 (en) * | 2003-06-07 | 2005-01-20 | Sekundärrohstoff-Verwertungszentrum Schwarze Pumpe Gmbh | Process to discharge organic wastes from a gas-tight hopper into a solid bed reactor under nitrogen pressure |
| CN101787086A (en) * | 2010-02-11 | 2010-07-28 | 南京工业大学 | Device and method for hydrolyzing plant hemicellulose by fermented citric acid wastewater |
| CN101869819A (en) * | 2010-06-18 | 2010-10-27 | 王伟跃 | Reactor for preparing propylene from oxygen-containing compound |
| CN202376909U (en) * | 2011-12-29 | 2012-08-15 | 浙江卫星石化股份有限公司 | Vertical reactor with two layers of catalysts |
| CN202951457U (en) * | 2012-09-21 | 2013-05-29 | 杭州耀洲生物科技有限公司 | Reaction kettle for solid-phase synthesis |
-
2012
- 2012-09-21 CN CN2012103579591A patent/CN102872763A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10325912A1 (en) * | 2003-06-07 | 2005-01-20 | Sekundärrohstoff-Verwertungszentrum Schwarze Pumpe Gmbh | Process to discharge organic wastes from a gas-tight hopper into a solid bed reactor under nitrogen pressure |
| CN101787086A (en) * | 2010-02-11 | 2010-07-28 | 南京工业大学 | Device and method for hydrolyzing plant hemicellulose by fermented citric acid wastewater |
| CN101869819A (en) * | 2010-06-18 | 2010-10-27 | 王伟跃 | Reactor for preparing propylene from oxygen-containing compound |
| CN202376909U (en) * | 2011-12-29 | 2012-08-15 | 浙江卫星石化股份有限公司 | Vertical reactor with two layers of catalysts |
| CN202951457U (en) * | 2012-09-21 | 2013-05-29 | 杭州耀洲生物科技有限公司 | Reaction kettle for solid-phase synthesis |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130116 |